CN101797371B - Drug combination for weight-reducing massage - Google Patents

Abstract

A pharmaceutical composition for weight loss massage relates to the pharmaceutical composition, and the invention also relates to a preparation method of the massage cream for weight loss. The medicinal composition for weight loss massage of the present invention is composed of the following Chinese medicinal materials by weight: 8-16% of cassia twig, 4-14% of Chuanxiong, 4-14% of Zanthoxylum bungeanum, 8-16% of Cassia , Alisma 4-14%, Comfrey 4-14%, Old Ginger 32-40%. According to the pharmaceutical composition for weight loss massage of the present invention, the weight loss massage cream is used as a massage medium, which not only protects the skin, but also allows the medicine to enter the body through transdermal, and can reduce the toxic and side effects of the medicine during internal use to At least, it can increase the effect of weight loss without affecting the daily life and work of patients, and provides a new way of using traditional Chinese medicine for weight loss.

Description

A kind of medicinal composition for weight loss massage

technical field

The invention relates to a pharmaceutical composition, in particular to a massage cream for weight loss.

Background technique

With the improvement of people's life, obesity has increasingly become a disease that endangers people's health. Obesity not only brings inconvenience to personal activities, but also brings various diseases: diabetes, cardiovascular and cerebrovascular diseases, hyperlipidemia, fatty liver, dyspnea and many other pains. Obesity has attracted the attention of the World Health Organization , and regard obesity as one of the biggest hidden dangers of human diseases. For people's health, various slimming products emerge in an endless stream, but the effect that some of these products or methods have is not obvious, some have toxic and side effects, even damage people's health, and the better expense of effect is expensive.

Contents of the invention

The purpose of the present invention is to overcome the defects of the prior art and provide a medicinal composition for weight loss massage which has no toxic and side effects, obvious weight loss effect and low cost.

The medicinal composition for weight loss massage of the present invention is composed of the following Chinese medicinal materials by weight: 8-16% of cassia twig, 4-14% of Chuanxiong, 4-14% of Zanthoxylum bungeanum, 8-16% of Cassia , Alisma 4-14%, Comfrey 4-14%, Old Ginger 32-40%.

Described pharmaceutical composition for weight-reducing massage, the preparation method of its ointment is:

a. Guizhi, Chuanxiong and Zanthoxylum bungeanum are used to extract the volatile oil by steam distillation, separate the volatile oil for later use, and decoct the residual liquid;

b. Decoct the raffinate obtained in step a with Cassia sativa, Alisma and ginger with water for at least 3 times, each time for 45-90 minutes, filter, combine the filtrate, centrifuge, concentrate the supernatant to a thick paste-like extract, and set aside;

c. Combine white vaseline, stearic acid, lanolin, and glycerol monostearate in a water bath and heat to melt, add comfrey and fry for 1-3 minutes, filter while hot, keep warm at 75-85°C, add azone to dissolve and mix well;

d. Take the extract equivalent to 30% of the base weight, glycerin, water, Tween-80, heat in a water bath to 75-85°C, mix well, add the oil phase to the water phase while stirring, and stir until cold to obtain.

The supernatant in step b of the preparation method of the pharmaceutical composition for weight loss massage is concentrated to the point of medicinal material: thick ointment = 1: 0.6-0.95.

The pharmaceutical composition used for weight loss massage according to the present invention can add different bases according to the different dosage forms prepared from the pharmaceutical composition, white petrolatum, stearic acid, lanolin, glyceryl monostearate, etc. can be added when preparing the ointment A common base for ointment drugs.

When using the medicinal composition for weight loss massage of the present invention, first massage the part that needs to lose weight for 20-30 minutes, then apply the medicinal composition of the present invention, and rub it until the local skin is warm. , once a day. Massage regulates visceral functions by invigorating the spleen, clearing the stomach, clearing the small intestine, clearing the large intestine, rubbing the door, and transporting internal gossip, etc.; , Tianshu, Huaroumen, Wailing, etc. to adjust the Ren channel of the general yin; through kneading, pressing and rubbing the Pishu, Weishu, etc. to adjust the Governor channel of the governor's yang; Bone rubbing, rubbing the lumbosacral area and other operations can further regulate the viscera and blood of the whole body, and promote the patient's fat metabolism and other metabolic links, so as to achieve the effect of weight loss. Slimming massage cream is used as a massage medium, which not only protects the skin, but also allows the drug to enter the body through the skin, which can minimize the toxic and side effects of the drug during oral administration, and can increase the weight loss effect without affecting the daily life of the patient. Life and work provide a new way of using traditional Chinese medicine for weight loss.

The medicinal composition for weight loss massage of the present invention, in its formula, Guizhi is pungent, sweet and warm, Guixin, lung and bladder meridian, warming yang and transforming qi, can warm yang to reduce phlegm, and transform qi to promote water , as the monarch drug, can make the spleen yang strong, and the water, dampness, phlegm and water will be eliminated. Modern pharmacological research shows that the cinnamon aldehyde and other components in the cinnamon twig volatile oil can not only calm and analgesia, regulate the function of the nervous system, but also regulate blood circulation. Improve coronary flow. Alisma and Cassia are ministers. Alisma is sweet and mild in nature, and belongs to the kidney and bladder meridian. In addition to certain protein, amino acid, and metal elements K, Na, Mg, Ca, Fe, Mn, Cu, Zn, etc., the ingredients such as Alisma terpene alcohol have Very good lipid-lowering effect, it can reduce the body mass index of experimental obese rats, the fat index around the uterus and testis, and the content of serum triglycerides, and also has the effect of regulating immunity, regulating blood sugar and blood pressure; Cassia is sweet and bitter and slightly cold , returns to the liver and large intestine meridian, Cassia Cassiae contains chrysophanol, emodin and other substances, which can not only strengthen the weight loss and lipid-lowering effect of Cassia Cassiae, but also regulate the immune system and antibacterial; The power of accumulating stagnation guides the evil of turbid yin such as water dampness and phlegm to come out from below. Combined with Chuanxiong to promote blood circulation and remove blood stasis, and strengthen the power of the prodrug to eliminate accumulation and guide stagnation, Chuanxiong can not only improve heart and brain circulation, but also have a two-way regulating effect on the central nervous system and smooth muscle. Comfrey cools blood and activates blood, detoxifies and penetrates rashes, protects the skin, antibacterial, hypoglycemic, anti-inflammatory, anti-allergic, avoids the irritation of drugs, and its purple color can adjust the color of the plaster, so that patients are willing to accept it. Zanthoxylum bungeanum is pungent and hot, has a fragrant nature and flavor, warms the middle and relieves pain, kills insects and relieves itching. It can not only strengthen the effect of warming the yang and invigorating the spleen, but also protect the liver, stop diarrhea, resist ulcers, and fight bacteria. taste. Ginger can not only increase the osmotic absorption of drugs, but also adjust the nature and taste of drugs, anti-inflammatory, improve microcirculation, adjust the smell of ointment, and make patients feel fragrant and comfortable. The present invention first treats the root cause, that is, warms the yang and invigorates the spleen, so that the water-damp phlegm drink has no source of hair growth; Leading stagnation and other ways to get rid of. Because the administration method of the present invention is transdermally absorbed by means, it not only avoids the unfavorable factors of taking weight-loss drugs for a long time, but also plays the role of treating both symptoms and root causes of the drug; it does not affect the daily life of patients, and can achieve weight loss and lipid-lowering The purpose, and the cost is relatively low, so it is accepted by consumers. The prescription of the present invention contains a large amount of polysaccharides, amino acids and trace elements, and will not cause damage to local skin and subcutaneous tissue through transdermal absorption. , blood, immune, digestive and other system functions. Comfrey also has a special skin protection effect, which can reduce the irritation of the drug to the skin as much as possible. The above medicines are made into extracts, and bases such as white petrolatum, stearic acid, lanolin, azone, glycerin, Tween-80, glyceryl monostearate and the like are appropriately added to increase the transdermal absorption effect of the extracts. The dosage form is O/W, non-greasy, easy to remove, and further increases absorption.

Pharmaceutical composition of the present invention, through toxicological research:

1. Acute skin toxicity test

Take 12 big-eared white rabbits with a weight of 2.1-2.4Kg, both male and female, and divide them into 3 groups at random. 24 hours before administration, use a depilatory agent to remove the hair on both sides of the rabbit's back and spine. The hair removal range is equivalent to the body surface area. The first group is the low-dose group of the weight-loss massage medicinal composition, 2.5g of the weight-loss massage cream equivalent to the clinical dosage of adults is evenly applied to the depilatory area on the back of the rabbit, covered with gauze, and fixed with medical adhesive plaster. , after 24 hours, remove the residual massage cream with warm water. The second group is the high-dose weight-loss massage cream group, which is given 5g of massage cream, and the third group is the control group, which is given 5g of reference substance, which is 50g of medical vaseline, 10g of refined edible oil, and stirred evenly. The method was the same as that of the low-dose weight-loss massage cream group. The rabbits' behavior, fur luster, diet, eyes and mucous membranes, breathing, body weight and death were continuously observed for 7 days, and no toxic reaction was found. Then use a 16-gauge sterilized needle to scratch the sterilized skin of the depilated area on both sides of the rabbit's back and spine with the word "#". The observation index is the same as above, and compared with the control group. Results Massage ointment had no effect on the behavior, activities, fur luster, diet, eyes and mucous membranes, respiration, and body weight of rabbits with intact skin and damaged skin when externally applied at low doses and high doses. No rabbit died within 14 days of successive observations. No acute toxic reactions occurred.

2. Skin irritation test of slimming massage cream

(1) One-time administration skin irritation test

Take 6 big-eared white rabbits with a body weight of 2.1-2.4Kg, both male and female, and randomly divide them into 2 groups, 3 rabbits in each group, one group has intact skin, and the other group has damaged skin. 24 hours before the administration, the hair on both sides of the rabbit's back spine was removed with a depilatory agent, and the depilated area was about 50 cm ² on each side. In the damaged skin group, use a 16-gauge sterilized needle to slash the sterilized skin at the depilatory site to make a "#" break. The horizontal and vertical breaks are about 2 cm in length, and the degree of blood leakage is the same. Both groups of rabbits were coated with 3g of weight-loss massage cream on the left side of the back, and 3g of the reference substance on the right side of the back. The reference substance was 50g of medical vaseline and 10g of refined edible oil. Fix it with medical adhesive plaster, and after 24 hours, wash off the drug with warm water, observe the skin irritation reaction at the application site for 1 hour, 24 hours, 48 hours, and 72 hours, and evaluate the skin irritation reaction score and intensity according to Table 2 and 3, and the results show that; The medicine is all non-irritating to intact skin and damaged skin of rabbits.

(2) Multiple administration skin irritation test

Rabbits were selected, grouped, hair removed and damaged at the same time for skin irritation test. Both groups of rabbits were coated with massage ointment 3g on the left back and 3g of the control product on the right back, and the fixation method was the same as the skin irritation test. For 7 consecutive days, 24 hours after the last administration, wash off the drug with warm water, and observe the skin irritation reaction at the application site for 1 hour, 24 hours, 48 hours, and 72 hours. Stimulation score and strength evaluation were the same as before, and the results showed that multiple administrations had no irritation to intact skin and damaged skin of rabbits.

3. Skin allergy test

Take 30 guinea pigs with a body weight of 220-250 g, and divide them into 3 groups at random, 10 in each group, half male and half male, and set up a slimming massage cream test group, a blank control group and a positive control group. 24 hours before the administration, the hair on both sides of the back spine of the guinea pig was removed with a depilatory agent, and the depilated area was 3×3cm ² on each side. In the experimental group, 0.2 g of massage ointment was applied to the left depilatory area of each guinea pig, covered with gauze, fixed with medical adhesive plaster, and removed for 6 hours. On the 7th day and the 14th day, the same method was repeated once. The blank control group was coated with 0.2 ml of normal saline, and the positive control group was coated with 0.2 ml of 0.1% 2,4-dinitrochlorobenzene. The method was the same as that of the experimental group. On the 14th day after the last administration, each guinea pig in the experimental group was reapplied with 0.2g of massage cream on the right depilated area, fixed in the same way, removed the covering after 6h, observed immediately, and then observed again at 24h, 48h, and 72h respectively Allergic skin reactions. The blank control group and the positive control group were given 0.2ml of physiological saline and 0.2ml of 0.1% 2,4-dinitrochlorobenzene respectively, the method was the same as that of the experimental group.

Sensitization rate (%) = number of allergic animals ÷ number of tested animals × 100%

The results showed that neither the experimental group nor the blank group caused allergic reactions such as erythema and edema on the skin of guinea pigs, and the sensitization rate was 0%, while the sensitization rate of the positive control group was 100%. It shows that the slimming massage cream has no sensitization to guinea pig skin, and 2,4-dinitrochlorobenzene has extreme sensitization to guinea pig skin.

The above experimental results show that external application of slimming massage ointment on the intact skin and damaged skin of rabbits does not cause acute toxic reactions; once administration and multiple administrations are all non-irritating to intact skin and damaged skin of rabbits; initial sensitization contact No sensitization to guinea pig skin.

4. Clinical trials

Divide the patients into three groups, ointment rubbing group, push rubbing group and blank group, through t test, there is no significant difference in body weight, height and course of disease among three groups of patients (all P>0.05)

During the course of treatment, the weight-loss massage cream used by the cream rubbing group is the weight-loss massage medicinal composition made by the present invention. Each treatment is about 40 minutes in total, and it is treated once every other day, and 15 times is a course of treatment. Measure and record the relevant indicators, take a rest for one week and proceed to the next course of treatment, and count the curative effect after 3 courses of treatment. The massage group adopted the same massage procedure and method as the test group. The slimming massage cream used in the treatment process was changed to Johnson's Baby Body Oil, and the course of treatment and index detection and recording methods were the same as those in the experimental group. The blank group received no other special treatment, but was followed up once every 30 days, and related indicators were detected and recorded according to the method of the massage group in the test group.

The three groups of patients were given the corresponding planting form for each 418KJ heat energy equivalent at the first visit, and taught the patients the heat energy conversion method of food and exercise, and helped calculate the reasonable amount of food and exercise according to the specific conditions of different patients. Lectures on obesity health knowledge are held regularly, and each patient is guaranteed to attend at least 2 lectures to reduce the impact of external factors on clinical research.

Comparison of the changes in the average integral value of clinical symptoms in the three groups of patients:

There was no significant difference in the average integral value of clinical symptoms before treatment among the ointment rubbing group, the massage group, and the blank group (P>0.05), which were comparable. Before treatment, there was no significant difference between the massage group and the massage group (P>0.05), there was no significant difference between the massage group and the blank group (P>0.05), and there was no significant difference between the massage group and the blank group (P>0.05). It shows that there is no significant difference in the clinical symptoms of the three groups before treatment, and they are comparable. Comparing the average clinical symptom scores of the ointment rubbing group, the massage group and the blank group before and after treatment, except for the blank control group, the clinical symptom scores of the other two groups were all lower than those before treatment. After treatment, compared with before treatment, there was no significant difference in the blank control group (P>0.05), but there was a significant difference in the ointment group (P<0.01); there was a significant difference in the massage group (P<0.05). During the treatment, some children experienced a transient increase in appetite, which returned to normal after about a week, and no other adverse reactions were found.

Detailed ways

The present invention will be further described below in conjunction with the examples, but not limited to the examples.

Example 1

The pharmaceutical composition for weight loss massage of the present invention is composed of the following Chinese medicinal materials by weight: 12.2% cassia twig, 9.76% Chuanxiong, 9.76% pepper, 12.2% Cassia, 9.76% Alisma, comfrey 9.76%, ginger 36.56%, add matrix to prepare massage ointment, described matrix is the usual matrix of ointment medicines such as white petrolatum, stearic acid, lanolin, glyceryl monostearate.

Example 2

The medicinal composition for weight loss massage described in the Ming Dynasty is composed of the following Chinese medicinal materials in weight components: Guizhi 8%, Chuanxiong 4%, Zanthoxylum bungeanum 14%, Cassia 16%, Alisma 4%, Comfrey 14% %, ginger 40%, add matrix to prepare massage cream. The base is a base commonly used in ointment medicines such as white petrolatum, stearic acid, lanolin, glyceryl monostearate and the like.

Example 3

The medicinal composition for weight loss massage described in the Ming Dynasty is composed of the following Chinese medicinal materials in weight components: Guizhi 16%, Chuanxiong 14%, Zanthoxylum bungeanum 12%, Cassia 8%, Alisma 14%, Comfrey 4% %, ginger 32% and the balance in the matrix. The base is a base commonly used in ointment medicines such as white petrolatum, stearic acid, lanolin, glyceryl monostearate and the like.

Example 4

The medicinal composition for weight loss massage described in the Ming Dynasty is composed of the following Chinese medicinal materials by weight: 16% cassia twig, 14% chuanxiong, 4% pepper, 8% cassia, 14% alisma, 4% comfrey %, ginger 40% and the balance of the matrix. The base is a base commonly used in ointment medicines such as white petrolatum, stearic acid, lanolin, glyceryl monostearate and the like.

Example 5

The pharmaceutical composition used for weight loss massage of the present invention, the preparation method of its ointment is: the pharmaceutical composition of any proportion in embodiment 1, 2, 3 is prepared according to the following steps:

a. Guizhi, Chuanxiong and Zanthoxylum bungeanum are used to extract the volatile oil by steam distillation, separate the volatile oil for later use, and decoct the residual liquid;

b. Decoct the raffinate obtained in step a with Cassia sativa, Alisma and ginger with water for 3 times, each time for 60 minutes, filter, combine the filtrate for 3 times, centrifuge, and concentrate the supernatant to a thick paste, medicinal material: thick paste= 1:0.85, spare;

c. Combine white vaseline, stearic acid, lanolin, and glycerol monostearate in a water bath and heat to melt, add comfrey and fry for 2 minutes, filter with gauze while it is hot; keep warm at 75-85°C, add azone to dissolve and mix well;

d. Take the extract equivalent to 30% of the base weight, glycerin, water, Tween-80, heat in a water bath to 75-85°C, mix well, add the oil phase to the water phase while stirring, and stir until cold to obtain.

Example 6

a. Guizhi, Chuanxiong and Zanthoxylum bungeanum are used to extract the volatile oil by steam distillation, separate the volatile oil for later use, and decoct the residual liquid;

b. Decoct the raffinate obtained in step a with Cassia sativa, Alisma and ginger with water for at least 3 times, each time for 45 minutes, filter, combine the filtrate, centrifuge, concentrate the supernatant to a thick paste-like extract, and set aside;

c. Combine white petrolatum, stearic acid, lanolin, and glyceryl monostearate in a water bath and heat to melt, add comfrey and fry for 3 minutes, filter while hot, keep warm at 85°C, add azone to dissolve and mix well;

d. Take the extract equivalent to 30% of the base weight, glycerin, water, Tween-80, heat in a water bath to 85°C, mix well, add the oil phase to the water phase while stirring, and stir until cold to obtain.

The supernatant in step b of the preparation method of the pharmaceutical composition for weight loss massage is concentrated to a ratio of medicinal material: thick ointment = 1:0.6.

Example 7

a. Guizhi, Chuanxiong and Zanthoxylum bungeanum are used to extract the volatile oil by steam distillation, separate the volatile oil for later use, and decoct the residual liquid;

b. Decoct the raffinate obtained in step a with Cassia sativa, Alisma and ginger with water for at least 3 times, each time for 90 minutes, filter, combine the filtrate, centrifuge, concentrate the supernatant to a thick paste-like extract, and set aside;

c. Combine white petrolatum, stearic acid, lanolin, and glyceryl monostearate in a water bath and heat to melt, add comfrey and fry for 1 min, filter while hot, keep warm at 75°C, add azone to dissolve and mix well;

d. Take the extract equivalent to 30% of the base weight, glycerin, water, Tween-80, heat in a water bath to 75°C, mix well, add the oil phase to the water phase while stirring, and stir until cold to obtain.

The supernatant in step b of the preparation method of the pharmaceutical composition for weight loss massage is concentrated to a ratio of medicinal material: thick ointment = 1:0.95.

Claims (2)

1. An ointment of a pharmaceutical composition for weight-loss massage, characterized in that it is made up of the following Chinese medicinal materials of the weight components: Guizhi 8-16%, Chuanxiong 4-14%, Chinese prickly ash 4-14%, grass root Ming 8-16%, Alisma 4-14%, Comfrey 4-14%, Old Ginger 32-40%, and its preparation method is: a. Guizhi, Chuanxiong and Zanthoxylum bungeanum are used to extract the volatile oil by steam distillation, separate the volatile oil for later use, and decoct the residual liquid; b. Decoct the raffinate obtained in step a with Cassia sativa, Alisma and ginger with water for at least 3 times, each time for 45-90 minutes, filter, combine the filtrate, centrifuge, concentrate the supernatant to a thick paste-like extract, and set aside; c. Combine white vaseline, stearic acid, lanolin, and glycerol monostearate in a water bath and heat to melt, add comfrey and fry for 1-3 minutes, filter while hot, keep warm at 75-85°C, add azone to dissolve and mix well; d. Take the extract equivalent to 30% of the base weight, glycerin, water, Tween-80, heat in a water bath to 75-85°C, mix well, add the oil phase to the water phase while stirring, and stir until cold to obtain. 2. The ointment of the pharmaceutical composition for weight loss massage according to claim 1, characterized in that, the supernatant described in step b is concentrated to the point where medicinal material: thick ointment = 1: 0.6-0.95.