CN101791328A - Traditional Chinese medicine oral liquid for treating swine eperythrozoonosis and preparation method thereof - Google Patents
Traditional Chinese medicine oral liquid for treating swine eperythrozoonosis and preparation method thereof Download PDFInfo
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- CN101791328A CN101791328A CN200910308054A CN200910308054A CN101791328A CN 101791328 A CN101791328 A CN 101791328A CN 200910308054 A CN200910308054 A CN 200910308054A CN 200910308054 A CN200910308054 A CN 200910308054A CN 101791328 A CN101791328 A CN 101791328A
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Abstract
The invention relates to traditional Chinese medicine oral liquid for treating swine eperythrozoonosis. In a formula, the traditional Chinese medicine oral liquid comprises various following raw materials in parts by weight: 10 to 30 parts of astragalus root, 10 to 30 parts of radix codonopsis pilosulae, 10 to 20 parts of stir-fried white atractylodes rhizome, 5 to 15 parts of tuckahoe and 5 to 20 parts of radix glycyrrhizae preparata. The traditional Chinese medicine oral liquid is prepared by the following implementation steps of: weighing various raw materials according to parts by weight, adding water according to the proportion of 1:8 of the total amount of the raw materials, soaking for 30min and decocting twice according to a conventional method; merging filtrate, then filtering and concentrating the filtrate to the relative density of 1.05 at the temperature of 40 to 50 DEG C; adding ethanol with the concentration of 95 percent, enabling the alcohol content of the final concentration to be 80 percent, stirring and standing for 24h; filtering, recovering the ethanol from the filtrate, adding distilled water solution, and concentrating the obtained solution to the relative density of 1.05 to 1.20 at the temperature of 40 to 50 DEG C; and finally, cooling the concentrated solution to room temperature and subpackaging by 200ml/bottle. The invention has reasonable prescription, simple preparation, obvious effect, no relapse and no medicine residue, and the cure rate is as high as more than 99 percent.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of swine eperythrozoonosis and preparation method thereof, particularly a kind of Chinese medicine oral liquid for the treatment of swine eperythrozoonosis and preparation method thereof.
Background technology
Swine eperythrozoonosis is to be parasitized the erythrocyte surface of pig or be free on a kind of zoonosis that causes in blood plasma, tissue fluid and the cerebrospinal fluid by Eperythrozoon.Clinically with heating, anemia, jaundice equipotential feature.The pig symptom of different days is different, and sow mainly shows as fertility performance and descends; Piglet then shows as the body constitution variation, anemia, and intestinal and respiratory tract infection increase; Growing and fattening pigs show as daily gain and descend acute haemolysis anemia; The boar hyposexuality, motility of sperm reduces.
In recent years, along with the continuous development of pig industry, swine eperythrozoonosis is popular general in China, and all hog areas all have this disease to take place.After pig infects Eperythrozoon, can cause pig body resistance, immunity to reduce, very easily cause the mixed infection of other diseases.What clinical common pig infected the Eperythrozoon sequela has swine fever, pig streptococcicosis, bowel oedema disease, porcine salmonellosis, a contagious pleuropneumonia etc., and sick mixed infections that have even several bring certain difficulty to clinic diagnosis.If imprecise, the malpractice of diagnosis, mortality rate is higher.
The treatment swine eperythrozoonosis adopts medicines such as antibiotic, sulfonamides, arsenic preparation to treat mostly both at home and abroad now, though symptom is alleviated to some extent, the color restoration of Corii Sus domestica skin is normal, still can detect eperythrozoon suis in body after the recovery, infects once more to give people or other animals.China does not also have excellent drug to control the generation of this disease at present, so effective control medicine of this disease of development treatment has crucial practical significance.
Summary of the invention
Main purpose of the present invention is to overcome above-mentioned weak point, and a kind of Chinese medicine oral liquid for preparing treatment swine eperythrozoonosis simple, evident in efficacy and preparation method thereof is provided.
The technical solution adopted in the present invention is for achieving the above object:
A kind of Chinese medicine oral liquid for the treatment of swine eperythrozoonosis is characterized in that: various raw materials in part by weight are in the prescription: Radix Astragali 10-30 part, Radix Codonopsis 10-30 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Poria 5-15 part, Radix Glycyrrhizae Preparata 5-20 part.
The preferable parts by weight of various raw materials are in the prescription: 20 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 10 parts in Poria, 10 parts of Radix Glycyrrhizae Preparatas.
Preparation process is as follows: take by weighing various raw materials by described weight portion, add water at 1: 8 in the total amount ratio of raw material, soak 30min, and decoct according to conventional method; The 40min of boiling back slow fire boiling for the first time filters; Filtering residue adds the water boiling back slow fire boiling 30min of 6 times of amounts again; Merging filtrate filters then, and it is 1.05 that temperature is concentrated into relative density 40 ℃ of-50 ℃ of following filtrates; Add concentration 95% ethanol, making final concentration contain the alcohol amount is 80%, stirs, and leaves standstill 24h; Filter, filtrate recycling ethanol adds the aqueous solution after distilling, and temperature is concentrated into relative density with it under 40 ℃-50 ℃ be 1.05-1.20; At last, concentrated solution is cooled to room temperature, is packed as the 200ml/ bottle.The effect of composition principle and each crude drug:
The Radix Astragali: slightly warm in nature, sweet in the mouth, cold; The effect that invigorating QI to consolidate the body surface resistance, hidroschesis detoxification, granulation promoting, diuresis, detumescent are arranged.Radix Astragali extract is yellow powdered material, and Main Ingredients and Appearance is: the folic acid of astragalus polysaccharides, flavone, choline, betanin, aminoacid, sucrose, glucuronic acid and trace.Has the cytophagous phagocytic function of enhancing; Enhancing antibody synthesizes enhancing immunity, has Detoxication.
Radix Codonopsis: property is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Character and Radix Codonopsis are similar, but branch is less, and only root upper end 1～3cm partly has ring grain, and matter is soft slightly, and the section crack is few.Little acid of distinguishing the flavor of.Be elongated cylindrical, crooked slightly, long 10-35cm, diameter 0.4-2cm.The root head has the top of most tuberculate stem traces to be recessed round point shape; Fine and close circular striation is arranged under the root head, and gradually sparse downwards, what have reaches half of total length, the few or nothing of cultivation product ring grain; Often there is the pitchy jelly at the break place that falls of the hole skin of growing crosswise that vertical wrinkle is all arranged and be dispersed in, supporting root.Matter is toughness slightly firmly or slightly, and section is smooth slightly, and crack or radial texture are arranged, and skin zone's yellowish white is to light brown, and woody part is faint yellow.Special aroma is arranged, and it is little sweet to distinguish the flavor of.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst.Be used for deficiency of vital energy deficiency, fatigue and weakness, dyspnea with rapid breath, insufficiency of the spleen lack of appetite, the edema of the face, chronic diarrhea proctoptosis.This product is clinical Qi-tonifying drug commonly used, and the function invigorating the spleen to benefit the lung is imitated person of modern times's ginseng and for a little less than, is applicable to various deficiency of vital energy deficiencies etc.
Rhizoma Atractylodis Macrocephalae (parched): invigorating the spleen and benefiting QI, dampness diuretic.Be used for weakness of the spleen and stomach, the lack of appetite distension, fatigue and weakness is had loose bowels.Be used for water-damp retention, phlegm retention, edema.Be used for the exterior deficiency spontaneous perspiration.
Poria: sweet in the mouth, light, property is flat.Promoting diuresis to eliminate damp pathogen is arranged, the function of spleen invigorating mind calming.Be used for edema, oliguria, seminal emission, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, the palpitation with fear insomnia waits disease.Poria has effects such as immunity, diuresis, calmness, blood sugar lowering, antitumor; Poria has protective effect to rats'liver damage due to the carbon tetrachloride, and the movable of glutamate pyruvate transaminase obviously reduced, and prevents hepatic necrosis.
Radix Glycyrrhizae Preparata: the Radix Glycyrrhizae root and rhizome contains potassium, the calcium salt that glycyrrhizin is a glycyrrhizic acid.Still contain liquiritin, liquiritigenin, isoliquiritin, different Radix Glycyrrhizae unit, neoliquriitin, neoisoliquiritin etc.The property flat, sweet in the mouth has detoxifcation, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Processed with honey cures mainly spleen and stomach function and goes down, and big loose stool is thin, weak heating and cough, cardiopalmus etc.
The combination principle of Chinese medicine composition is " potentiation detoxifcation ", and therefore, the different pharmacological action that medicine embodied of compatibility is also different.The said medicine compatibility, full side is able to treating both the principal and secondary aspects of a disease, strengthening vital QI to eliminate pathogenic factors, across-the-board regulation, Yin Yang balancing.This product can effectively be killed pathogenic infection, fast relief of symptoms.
The invention has the beneficial effects as follows: reasonable recipe of the present invention, preparation are simple, and heat-clearing and toxic substances removing, yin nourishing are brought down a fever, effect is remarkable, and cure rate is up to more than 99%, do not recur, no drug residue.Be widely used, but suitability for industrialized production.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1 (every part by 10g)
Take by weighing respectively: Radix Astragali 200g, Radix Codonopsis 200g, Rhizoma Atractylodis Macrocephalae (parched) 150g, Poria 100g, Radix Glycyrrhizae Preparata 100g.
Concrete preparation method: the total amount ratio in raw material adds water at 1: 8, soaks 30min, and decocts according to conventional method; The 40min of boiling back slow fire boiling for the first time filters; Filtering residue adds the water boiling back slow fire boiling 30min of 6 times of amounts again; Merging filtrate filters then, and it is 1.05 that temperature is concentrated into relative density 40 ℃ of-50 ℃ of following filtrates; Add concentration 95% ethanol, make final concentration contain the alcohol amount and be 80% (all unit meter) by weight, stir, leave standstill 24h; Filter, filtrate recycling ethanol adds the aqueous solution after distilling, and temperature is concentrated into relative density with it under 40 ℃-50 ℃ be 1.05-1.20; At last, concentrated solution is cooled to room temperature, packing 200ml/ bottle.
Get medicinal liquid that 75g left and right sides feedstock production forms and be used for the sick pig of 75-100kg, the pig of body weight about 50kg cut down according to the circumstance.
Embodiment 2 (every part by 10g)
Take by weighing respectively: Radix Astragali 100g, Radix Codonopsis 120g, Rhizoma Atractylodis Macrocephalae (parched) 100g, Poria 50g, Radix Glycyrrhizae Preparata 50g.
Preparation method and other are with embodiment 1.
Embodiment 3 (every part by 10g)
Take by weighing respectively: Radix Astragali 300g, Radix Codonopsis 280g, Rhizoma Atractylodis Macrocephalae (parched) 200g, Poria 150g, Radix Glycyrrhizae Preparata 200g.
Preparation method and other are with embodiment 1.
Usage and dosage: the every 100ml of this product converts water 100L, 1 dose/day, can drink logotype 5-7 days at twice; The serious symptom doubled amount is used.
The applicating example contrast:
Case: on July 5th, 2008, the 50 remainder pigs (body weight 40-50kg does not wait) that a certain self-employed pig raiser in Tianjin raises, begin to have 23 pigs morbidity hyperpyrexia body temperature 40-42.5 ℃, do not eat, body is red, yellowish urine.Find that through the inspection of blood picture Eperythrozoon is radial, zigzag, deformity etc.; Be diagnosed as swine eperythrozoonosis.
23 sick pigs are divided into two groups carry out therapeutic test, invention medicine group: 1 dose/day, logotype 5 days after the drug withdrawal, continues clinical observation 7 days.
Curative effect comparative result such as following table:
| Group | Effective percentage % | Mortality rate % | Cure rate % | Blood Eperythrozoon negative conversion rate % |
| Medicine group of the present invention (12) | ??100 | ??0 | ??100 | ????100 |
| 10% doxycycline soluble powder (11) | ??91 | ??9 | ??82 | ????87 |
The result shows that medicine of the present invention obviously is better than the antibiotic medicine treatment to the therapeutic effect of swine eperythrozoonosis, and has significant preventive and therapeutic effect.
Above-mentioned detailed description of the Chinese medicine oral liquid and preparation method thereof of treatment swine eperythrozoonosis being carried out with reference to embodiment; be illustrative rather than determinate; can exemplify out several embodiment according to limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. Chinese medicine oral liquid for the treatment of swine eperythrozoonosis, it is characterized in that: various raw materials in part by weight are in the prescription: Radix Astragali 10-30 part, Radix Codonopsis 10-30 part, Rhizoma Atractylodis Macrocephalae (parched) 10-20 part, Poria 5-15 part, Radix Glycyrrhizae Preparata 5-20 part.
2. the Chinese medicine oral liquid of treatment swine eperythrozoonosis according to claim 1 is characterized in that: the preferable parts by weight of various raw materials are in the prescription: 20 parts of the Radixs Astragali, 20 parts of Radix Codonopsis, 15 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 10 parts in Poria, 10 parts of Radix Glycyrrhizae Preparatas.
3. the preparation method of the Chinese medicine oral liquid of a treatment swine eperythrozoonosis according to claim 1 and 2, it is characterized in that: implementation step is as follows: take by weighing various raw materials by described weight portion, total amount ratio in raw material adds water at 1: 8, soaks 30min, and decocts according to conventional method; The 40min of boiling back slow fire boiling for the first time filters; Filtering residue adds the water boiling back slow fire boiling 30min of 6 times of amounts again; Merging filtrate filters then, and it is 1.05 that temperature is concentrated into relative density 40 ℃ of-50 ℃ of following filtrates; Add concentration 95% ethanol, making final concentration contain the alcohol amount is 80%, stirs, and leaves standstill 24h; Filter, filtrate recycling ethanol adds the aqueous solution after distilling, and temperature is concentrated into relative density with it under 40 ℃-50 ℃ be 1.05-1.20; At last, concentrated solution is cooled to room temperature, is packed as the 200ml/ bottle.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102688334A (en) * | 2012-06-18 | 2012-09-26 | 郑州牧业工程高等专科学校 | Chinese and western medicine mixture for improving immunologic function of livestock and preparation method thereof |
| CN103599452A (en) * | 2013-11-12 | 2014-02-26 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating mycoplasma suis and preparation method thereof |
| CN103960542A (en) * | 2014-05-20 | 2014-08-06 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating swine eperythrozoonosis |
| CN104922258A (en) * | 2015-06-01 | 2015-09-23 | 新疆农业大学 | Strangles powder and application thereof to preparation of drugs for preventing and treating strangles and abscess |
| CN106943479A (en) * | 2017-04-28 | 2017-07-14 | 福建中农牧生物药业有限公司 | A kind of plant additive for improving piglet survival rate and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688334A (en) * | 2012-06-18 | 2012-09-26 | 郑州牧业工程高等专科学校 | Chinese and western medicine mixture for improving immunologic function of livestock and preparation method thereof |
| CN103599452A (en) * | 2013-11-12 | 2014-02-26 | 青岛绿曼生物工程有限公司 | Traditional Chinese medicine composition for treating mycoplasma suis and preparation method thereof |
| CN103960542A (en) * | 2014-05-20 | 2014-08-06 | 山东新希望六和集团有限公司 | Feed and traditional Chinese medicine composition for preventing and treating swine eperythrozoonosis |
| CN103960542B (en) * | 2014-05-20 | 2016-04-20 | 山东新希望六和集团有限公司 | A kind of feed for preventing and treating swine eperythrozoonosis and Chinese medicine composition |
| CN104922258A (en) * | 2015-06-01 | 2015-09-23 | 新疆农业大学 | Strangles powder and application thereof to preparation of drugs for preventing and treating strangles and abscess |
| CN104922258B (en) * | 2015-06-01 | 2018-04-20 | 新疆农业大学 | A kind of strangles powder and the application in prevention strangles and abscess medicine is prepared |
| CN106943479A (en) * | 2017-04-28 | 2017-07-14 | 福建中农牧生物药业有限公司 | A kind of plant additive for improving piglet survival rate and preparation method thereof |
| CN106943479B (en) * | 2017-04-28 | 2020-09-22 | 福建中农牧生物药业有限公司 | Plant additive for improving survival rate of piglets and preparation method thereof |
| CN109771521A (en) * | 2019-03-11 | 2019-05-21 | 阜新登峰农牧有限公司 | The double yellow double essence arts of Chinese medicine for preventing and treating pig epidemic fever disease dissipate |
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Application publication date: 20100804 |