CN101773665A - Reproductive protective agent facilitating human fertilization - Google Patents
Reproductive protective agent facilitating human fertilization Download PDFInfo
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- CN101773665A CN101773665A CN201010023015A CN201010023015A CN101773665A CN 101773665 A CN101773665 A CN 101773665A CN 201010023015 A CN201010023015 A CN 201010023015A CN 201010023015 A CN201010023015 A CN 201010023015A CN 101773665 A CN101773665 A CN 101773665A
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Abstract
The invention belongs to the field of human reproductive health, and relates to reproductive protective agent facilitating human fertilization. The reproductive protective agent is divided into three independent formulas, and is used sequentially before, during and after having sex. The three formulas of the reproductive protective agent have different functions, can not only protect the integrity of vaginal mucosa of women, reduce the friction resistance and the mechanical damage to the male genitalia and the female reproductive tract caused by friction when being used together, but also can significantly increase the number of the left female reproductive tract local sperms, prolong the survival time of the sperms, enhance the movement activity of the sperms and protect the activity of the sperms so that the sperms are not killed by various local reproductive tract harmful factors, so as to achieve the purpose of improving the success rate of single fertilization.
Description
Technical field
The invention belongs to human reproduction's health field, particularly a kind of reproductive protective agent that helps human fertilization.
Background technology
1) about some physiology and the pathomechanism of natural fertilization
Human natural conception is undertaken by vagina.In the same branch of a family process, the seminal fluid that bridegroom's or husband's side genitals discharges can be preserved a few hours to a couple of days in vagina, and wherein viable sperm is up to fallopian tube by cervix uteri, uterine cavity, finishes the fertilization process with wife's side ovum.For a variety of reasons, the fertilization success rate is not absolutely, generally about 30%.
There is such women clinically, because special physiological, the pathologic condition of its vagina and uterus neck, for example: disorder of hormone secretion, down the reproductive tract external secretion is unusual, and microenvironment disorder etc. due to the vaginosis, cervicitis, influenced motility of sperm, its rate of passing is descended greatly, cause infertile for a long time.
Also there is lack of quantity of spermatic fluid in male self aspect, does not liquefy, liquefaction late, multiple pathologic condition such as spermatozoon activity is poor, quantity is few.This may be the male because of reproductive tract, locate to take place pathological changes as prostate, testis, deferent duct etc., cause microcirculation disturbance, chronic inflammatory disease, and under comprehensive functions such as tobacco and wine bad habit, cause.They can be separately or with wife's side factor, causes infertility.
In the same branch of a family, the mucous secretion of wife's side vagina, cervix uteri is to be beneficial to the contact of both sides' genitals, reduces the physiological phenomenon of relative motion frictional resistance.But wherein contained sterilization and cause scorching composition: oxygen-derived free radicals, lysosomal enzyme, prostaglandin, all kinds of secreting type antibody, phagocytic leukocyte etc. also become and hinder amphigameous key factor.This natural anti-fertilization barrier is suffered from autoimmune, vagina and cervical disease on the wife's side, and can show more obviously under the not high situation of bridegroom's or husband's side seminal fluid and sperm quality.
In the industrial society, three-waste pollution is serious day by day, and personal work is tending towards nervous, high strength, and this makes all to have men and women's fertility in various degree and descends.The present invention promptly is that contact comfort level and intravaginal environment angle are started with when improve having sexual intercourse, and initiatively improves motility of sperm and remaining time, increases it passes rate to the cervical mucus bolt a kind of gravidity assisting measure.This method of implementing by reproduction protection promoter can be improved the same branch of a family quality from subjective; Objectively, provide more fertilization chances for both sides.
2) present Research of vaginal lubrication, short spermatozoon activity aspect
Reduce the frictional resistance aspect, multiple chemical products have this effect, as: paraffin oil, vaseline, silicone oil, various surfactant, Pulvis Talci etc.These traditional chemicals are used widely clinical, but they can cause lethal effect to sperm mostly, therefore can't satisfy the reproduction purposes.Need explore a kind of lubricated composition of suitable sperm survival.The viscosity of this prescription should be moderate, and the interior molecules structure is remarkable to the retention effect of moisture, and low to the space steric effect of sperm motility.
Nontoxic some food or drug additive,, figuration lubricated because of having and protective effect can be used.Such as: Polyethylene Glycol has good lubricity, and methylcellulose has film property and gel character, and glycerol has the cyto-architectural function of protection.But, they still respectively have shortcoming, because of thickness comparatively, can pull sperm such as: Polyethylene Glycol, reduce its mobility; Methylcellulose can precipitate in dehydration, meets salt and can separate out; Glycerol is the thickness liquid state, is easy to suction, easily with gravity flow, causes loss.So, have only the three is used, just can receive better effects.
The capacitation aspect, some natural Enzymes that cervix uteri, uterine cavity and fallopian tube contain have played main effect, such as: glycosidase, amylase, protease, sialidase etc. can be degraded and be covered the decapacitation factor at sperm top, make it to penetrate corona radiata and zona pellucida, obtain and the bonded ability of ovum endochylema.Moreover, other various bioactive molecules, special Organic substance also have the effect that makes capacitation, comprising: heparin, estrogen, high density lipoprotein, cyclodextrin, phosphatidylinositol-specific phospholipase C etc.When being designed for the reproductive tract protective agent that improves the fertilization success rate, need rationally choose the part in these useful compositions, carry out scientific formula, reaching best capacitation effect, and guarantee that these functional moleculars have long period of activity in joining reagent.
Strengthen sperm life, functional activity and motor capacity aspect, Chinese medicine is as Radix Codonopsis, Radix Ophiopogonis, vitamin is as B, D class, and ion is as Zn
2+, Ca
2+Deng, chemical compound as: fructose, ATP etc. are all powerful, can select wherein valuable person to be made up, and play the effect that improves the fertilization success rate.
Summary of the invention
The object of the present invention is to provide a kind of reproductive protective agent that helps human fertilization, its vaginal mucosa that can shield women lowers frictional resistance, reduces the mechanical injuries that male genital organ and female genital tract cause because of friction.The protective agent prescription has the sperm time-to-live of prolongation, strengthens the motion vigor and protects sperm to avoid the effect that all kinds of hazard factor are killed and wounded, and improves single fertilization success rate.
Reproductive protective agent of the present invention is divided into three ingredients, i.e. one, two and No. three prescription.
1, chemical compound composition and the content in the prescription (figuration and slow release, maintenance prescription):
Methylcellulose 0.5～5g/100mL;
Ethylene glycol 1～10mL/100mL;
Human albumin 1～10g/100mL;
Radix Codonopsis 1～5g/100mL;
Radix Ophiopogonis 1～5g/100mL;
Fructose 0.1～10mmol/100mL;
Lactose 0.1～10mmol/100mL;
EDTA?0.001～0.1mmol/100mL；
Sodium chloride 0.8～0.9g/100mL;
Potassium chloride 0.01～0.1g/100mL;
Vitamin E 1～10mg/100mL;
Vitamin C 1～10mg/100mL;
Vitamin B1 1～10mg/100mL;
Vitamin B2 1～10mg/100mL;
Vitamin B12 1～10mg/100mL;
Lysozyme 1～100mg/100mL;
Gentamycin 1～100,000 units/100mL.
In this prescription, methylcellulose and ethylene glycol have played figuration and slow releasing function, and human albumin and EDTA play the effect that the protection sperm is not subjected to intravaginal enzyme and microbial damage.Lysozyme and gentamycin have played the effect of killing microorganisms.Various vitamin, saccharide and Radix Codonopsis, Radix Ophiopogonis, the chemical constituent of kind kept spermatozoon activity.Sodium chloride and potassium chloride provide osmotic pressure and ionic environment.These a few class materials are united use, can make the less destruction that is subjected to the local environment factor of intravaginal sperm, reduced loss, and guarantee to carry sperm to the cervix uteri direction continually.
2, chemical compound composition and the content in No. two prescriptions (energization, liquefaction and antiinflammatory prescription):
Heparin 1～1,000,000 units/100mL;
Hydrocortisone 100～1000mg/100mL;
Estradiol benzoate 1～2000mg/100mL;
Fructose 0.1～10mmol/100mL;
ATP?0.1～10mg/100mL；
Coenzyme A 0.1～100 unit/100mL;
Lysozyme 1～100mg/100mL;
Hyaluronidase 10～1000 units/100mL;
Amylase 10～1000 units/100mL;
Glycosidase 10～1000 units/100mL;
Trypsin 10～1000 units/100mL;
People's hoptoglobin 1～10mg/100mL;
Radix Codonopsis 1～5g/100mL;
Radix Ophiopogonis 1～5g/100mL.
In this prescription, people's hoptoglobin, hydrocortisone regulating liver-QI have antiinflammatory and promote microcirculatory effect, and estradiol benzoate can change the cervical mucus shape, makes it to be easy to be passed by sperm.Hyaluronidase, amylase, glycosidase, tryptic effect are to help seminal fluid liquefaction and capacitation.ATP, coenzyme A, Radix Codonopsis, Radix Ophiopogonis are used to increase motility of sperm.Lysozyme is used for killing microorganisms, and minimizing will be infected and introduce the chance that goes up reproductive tract.
3, chemical compound composition and the content in No. three prescriptions (cleaning, infiltration and lubricated prescription):
Glycerol 1～10mL/100mL;
Chlorhexidine 0.01～0.1g/100mL;
Metronidazole 0.01～0.1g/100mL;
Fluconazol 0.01～0.1g/100mL.
In this prescription, glycerol is used to increase vaginal lubrication, and chlorhexidine, metronidazole and fluconazol are used to kill the intravaginal harmful microorganism.
Three concrete usings method of prescription are as follows: before the same branch of a family, the wife's side is earlier with No. three prescription washing vaginas, play clean vagina, discharge impurity, kill pathogen, pre-lubrication and improve the local blood circulation effect.In the same branch of a family, fill a prescription with No. two in the wife's side, fills a prescription with No. one in the bridegroom's or husband's side.No. two semen liquefactions of having filled a prescription, the dilution cervical secretions, inflammation-inhibiting reduces immunologic rejection, makes the capacitation effect.No. one prescription can reduce frictional resistance, and protection contact skin and mucosa are avoided damage, and for sperm provides energy, screening machine meeting and retains the space, slowly releases high motile sperm.Behind the same branch of a family, prescription is reused on the wife's side No. one.Be injected into vagina, rely on volume occupy-place effect, the shutoff vaginal outlet reduces seminal fluid and runs off.
The specific embodiment
Embodiment 1
Get methylcellulose 0.5g; Ethylene glycol 1mL; Human albumin 1g; Radix Codonopsis 1g; Radix Ophiopogonis 1g; Fructose 0.1mmol; Lactose 0.1mmol; EDTA 0.001mmol; Sodium chloride 0.8g; Potassium chloride 0.1g; Vitamin E 1mg; Vitamin C 1mg; VB11 mg; Vitamin B2 1mg; Vitamin B12 1mg; Lysozyme 1mg; Gentamycin 10,000 units are dissolved in the 100mL deionized water, promptly get prescription of protective agent.
Taking heparin 10,000 units; Hydrocortisone 100mg; Estradiol benzoate 1mg; Fructose 0.1mmol; ATP 0.1mg; Coenzyme A 0.1 unit; Lysozyme 1mg; Hyaluronidase 10 units; Amylase 10 units; Glycosidase 10 units; Trypsin 10 units; People's hoptoglobin 1mg; Radix Codonopsis 1g; Radix Ophiopogonis, 1g was dissolved in the 100mL deionized water, promptly got No. two prescriptions of protective agent.
Get glycerol 1mL; Chlorhexidine 0.01g; Metronidazole 0.01g; Fluconazol 0.01g is dissolved in the 100mL deionized water, promptly gets No. three prescriptions of protective agent.
The fill of above-mentioned three kinds of prescriptions in different reagent bottle, is placed packing box, and encloses operation instructions, promptly become the reproductive protective agent finished product that can directly use.
During the same branch of a family, as by correct using method, use above-mentioned reproductive protective agent prescription one～three successively after, extract seminal fluid from wife's side intravaginal again and analyze, can find that the sperm quantity that intravaginal retains significantly increases, vigor increases.And the sperm quantity of finding in the cervical mucus bolt also significantly increases, and this prompting chance of becoming pregnant will increase.
Embodiment 2
Get methylcellulose 5g; Ethylene glycol 10mL; Human albumin 10g; Radix Codonopsis 5g; Radix Ophiopogonis 5g; Fructose 10mmol; Lactose 10mmol; EDTA 0.1mmol; Sodium chloride 0.9g; Potassium chloride 0.01g; Vitamin E 10mg; Vitamin C 10mg; VB11 0mg; Vitamin B2 10mg; Vitamin B12 10mg; Lysozyme 100mg; Gentamycin 100,000 units are dissolved in the 100mL deionized water, promptly get prescription of protective agent.
Taking heparin 1,000,000 units; Hydrocortisone 1000mg; Estradiol benzoate 2000mg; Fructose 10mmol; ATP10mg; Coenzyme A 100 units; Lysozyme 100mg; Hyaluronidase 1000 units; Amylase 1000 units; Glycosidase 1000 units; Trypsin 1000 units; People's hoptoglobin 10mg; Radix Codonopsis 5g; Radix Ophiopogonis, 5g was dissolved in the 100mL deionized water, promptly got No. two prescriptions of protective agent.
Get glycerol 10mL; Chlorhexidine 0.1g; Metronidazole 0.1g; Fluconazol 0.1g is dissolved in the 100mL deionized water, promptly gets No. three prescriptions of protective agent.
The fill of above-mentioned three kinds of prescriptions in different reagent bottle, is placed same packing box, and encloses operation instructions, promptly obtain the reproductive protective agent finished product that can directly use.
During the same branch of a family, press correct method, use above-mentioned reproductive protective agent prescription one～three successively, can extract seminal fluid from wife's side intravaginal then and analyze.Investigation finds that the sperm quantity that intravaginal retains extremely significantly increases, vigor increases.And the sperm quantity of finding in the cervical mucus bolt also significantly increases, and points out the chance of becoming pregnant to increase.
Claims (4)
1. a reproductive protective agent that helps human fertilization is characterized in that it has three independently ingredients, promptly fills a prescription for one, two and No. three, and these three prescriptions use in the same branch of a family process successively by No. three, No. two, No. one order.
2. the reproductive protective agent that helps human fertilization as claimed in claim 1 is characterized in that chemical compound composition and the content in the described prescription is:
Methylcellulose 0.5～5g/100mL;
Ethylene glycol 1～10mL/100mL;
Human albumin 1～10g/100mL;
Radix Codonopsis 1～5g/100mL;
Radix Ophiopogonis 1～5g/100mL;
Fructose 0.1～10mmol/100mL;
Lactose 0.1～10mmol/100mL;
EDTA?0.001～0.1mmol/100mL；
Sodium chloride 0.8～0.9g/100mL;
Potassium chloride 0.01～0.1g/100mL;
Vitamin E 1～10mg/100mL;
Vitamin C 1～10mg/100mL;
Vitamin B1 1～10mg/100mL;
Vitamin B2 1～10mg/100mL;
Vitamin B12 1～10mg/100mL;
Lysozyme 1～100mg/100mL;
Gentamycin 1～100,000 units/100mL.
3. the reproductive protective agent that helps human fertilization as claimed in claim 1 is characterized in that chemical compound composition and the content in described No. two prescriptions is:
Heparin 1～1,000,000 units/100mL;
Hydrocortisone 100～1000mg/100mL;
Estradiol benzoate 1～2000mg/100mL;
Fructose 0.1～10mmol/100mL;
ATP?0.1～10mg/100mL；
Coenzyme A 0.1～100 unit/100mL;
Lysozyme 1～100mg/100mL;
Hyaluronidase 10～1000 units/100mL;
Amylase 10～1000 units/100mL;
Glycosidase 10～1000 units/100mL;
Trypsin 10～1000 units/100mL;
People's hoptoglobin 1～10mg/100mL;
Radix Codonopsis 1～5g/100mL;
Radix Ophiopogonis 1～5g/100mL.
4. the reproductive protective agent that helps human fertilization as claimed in claim 1 is characterized in that chemical compound composition and the content in described No. three prescriptions is:
Glycerol 1～10mL/100mL;
Chlorhexidine 0.01～0.1g/100mL
Metronidazole 0.01～0.1g/100mL
Fluconazol 0.01～0.1g/100mL.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010023015A CN101773665A (en) | 2010-01-20 | 2010-01-20 | Reproductive protective agent facilitating human fertilization |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010023015A CN101773665A (en) | 2010-01-20 | 2010-01-20 | Reproductive protective agent facilitating human fertilization |
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| CN101773665A true CN101773665A (en) | 2010-07-14 |
Family
ID=42510339
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010023015A Pending CN101773665A (en) | 2010-01-20 | 2010-01-20 | Reproductive protective agent facilitating human fertilization |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454416A (en) * | 2013-09-22 | 2013-12-18 | 四川大学华西第二医院 | Method for detecting neuraminidase influencing sperm functions |
| CN107308187A (en) * | 2017-06-29 | 2017-11-03 | 冯浩 | Vagina nutrient solution for improving sperm fertilizing ability and then raising natural conception probability and preparation method thereof |
-
2010
- 2010-01-20 CN CN201010023015A patent/CN101773665A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103454416A (en) * | 2013-09-22 | 2013-12-18 | 四川大学华西第二医院 | Method for detecting neuraminidase influencing sperm functions |
| CN103454416B (en) * | 2013-09-22 | 2016-04-13 | 四川大学华西第二医院 | Affect the sialidase detection method of sperm function |
| CN107308187A (en) * | 2017-06-29 | 2017-11-03 | 冯浩 | Vagina nutrient solution for improving sperm fertilizing ability and then raising natural conception probability and preparation method thereof |
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