CN101766687A - Inflammation diminishing capsules prepared from baical skullcap root and golden thread and preparation method thereof - Google Patents
Inflammation diminishing capsules prepared from baical skullcap root and golden thread and preparation method thereof Download PDFInfo
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- CN101766687A CN101766687A CN201010114753A CN201010114753A CN101766687A CN 101766687 A CN101766687 A CN 101766687A CN 201010114753 A CN201010114753 A CN 201010114753A CN 201010114753 A CN201010114753 A CN 201010114753A CN 101766687 A CN101766687 A CN 101766687A
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- powder
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- skullcap root
- baical skullcap
- granulating
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- 239000002775 capsule Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 206010061218 Inflammation Diseases 0.000 title abstract description 4
- 241000050051 Chelone glabra Species 0.000 title abstract 7
- 241000099774 Cuscuta salina Species 0.000 title abstract 3
- 230000003467 diminishing effect Effects 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 239000000843 powder Substances 0.000 claims abstract description 28
- 238000005516 engineering process Methods 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000001694 spray drying Methods 0.000 claims abstract description 9
- 238000005303 weighing Methods 0.000 claims abstract description 7
- 239000007921 spray Substances 0.000 claims abstract description 6
- 238000005507 spraying Methods 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 4
- 238000005469 granulation Methods 0.000 claims description 19
- 230000003179 granulation Effects 0.000 claims description 19
- 239000008187 granular material Substances 0.000 claims description 16
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 14
- 230000001741 anti-phlogistic effect Effects 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 238000009835 boiling Methods 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000011230 binding agent Substances 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims description 3
- 238000007602 hot air drying Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000007664 blowing Methods 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000012567 medical material Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 238000010992 reflux Methods 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012946 outsourcing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000009818 secondary granulation Methods 0.000 description 1
- 208000023409 throat pain Diseases 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
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Abstract
The invention discloses inflammation diminishing capsules prepared from baical skullcap root and golden thread and a preparation method thereof. The method is characterized in that a granulating process adopts spray drying one-step granulating technology, liquor is used as adhesive, the medicinal powder is blown to be stuck with the liquor together and directly prepared into dry grains with even size, and the dry grains are filled into capsules. The process of one-step granulating technology comprises the following steps: weighing a proper amount of baical skullcap root powder serving as an auxiliary material and feeding the baical skullcap root powder into a fluidized bed granulating chamber of a spray drying granulator, and blowing hot air into the fluidized bed granulating chamber to preheat the baical skullcap root powder; starting an air blower to make the air enter the granulating chamber through a filter device and a heat exchanger from an air inlet, make a negative pressure formed in the granulating chamber, and make the medicinal powder float up and down for preheating and drying; spraying a proportional quantity of medicinal extract concentrated solution to the granulating chamber through a spray nozzle to form fog drops, and agglomerating the fog drops and the baical skullcap root powder to form porous grains; blowing the hot air to dry the grains while spraying, and vibrating a powder catching bag at regular intervals; and repeating the operation till the specified amount of medicinal extract concentrated solution is completely sprayed. The method is suitable for the preparation and production of the inflammation diminishing capsules prepared from the baical skullcap root and the golden thread.
Description
Technical field
The present invention relates to a kind of two yellow antiphlogistic capsules and preparation method thereof, belong to the Chinese medicine technical field.
Background technology
Two yellow antiphlogistic capsules be a kind of be the tcm product that raw material is made with Radix Scutellariae and Radix Berberidis (another name Radix Berberidis soulieanae), it belongs to drug supporting healthy energy, has effects such as heat clearing away, detoxifcation, antiinflammatory, can be used for quench, controls throat pain, only diarrhoea, dysentery chronic dysentery etc.
Publication number CN1709334 discloses a kind of Shuanghuan anti-inflammation dispersion tablet of radix berberidis and radix scutellariae and preparation method thereof, adopts Radix Berberidis, Radix Scutellariae and polyvinyl alcohol to make raw material.Granted publication CN100341487 discloses a kind of two yellow anti-inflammatory dripping pills that is used for antiinflammatory, and this invention is to be a kind of drug composition oral preparation that feedstock production forms with Radix Berberidis, Radix Scutellariae etc. two flavor Chinese medicines.Two yellow antiphlogistic capsules have been listed Pharmacopoea Chinensis in.
Traditional two yellow antiphlogistic capsule production technology exists because extractum is more, and extractum is with after medicated powder mixes, and granulation has difficulties, and needs by secondary granulation, pulverizing, and screen cloth is then fragile; And the traditional handicraft production cycle is long, and product particle is inhomogeneous; Content uniformity was wayward when capsule was filled, and content is also inhomogeneous.
Summary of the invention
The objective of the invention is,, granulating process is improved, release a kind of two yellow antiphlogistic capsule granulation new technology at the problem that exists in two yellow antiphlogistic capsule traditional handicrafts.
Technical scheme of the present invention is:
Adopting spray drying one-step palletizing technology, is binding agent with the medicinal liquid, and medicated powder is blown afloat, and is bonded together with medicinal liquid, directly makes the dried granule of big or small uniformity, recharges capsule.
Spray drying-one-step palletizing process is as follows:
It is indoor as the fluidized bed granulation that adjuvant drops into spray-drying pelleting machine to take by weighing an amount of Radix Scutellariae powder, rises and closes the granulation chamber, sends into the hot blast of 100 ℃ of temperature, makes Radix Scutellariae powder " boiling " preheating.The granulation chamber interior is a porous plate, and going up auxilliaryly has 180 order stainless steel meshs, start blower fan make air by air inlet install after filtration with heat exchanger after, enter the granulation chamber by container bottom again, and making the indoor formation negative pressure of granulating, medicated powder then fluctuates and rolls, and forms " boiling " and preheating and drying.After preheating was qualified, the extract drugs concentrated solution with proportional quantities was sprayed on the granulation chamber and forms droplet through spray nozzle again, and is condensed into the cellular granule with the Radix Scutellariae powder body.Spraying on one side Yi Bian send the hot air drying granule, is vibrated powder at regular intervals and is captured bag.Repeatable operation until the specified amount of medicinal extract concentrated solution has been sprayed, and till the granule of taking a sample to check requirement up to specification, is promptly shut down discharging, granulate, promptly.Owing to adopt one-step palletizing technology, the medicine concentrated solution density that enters the granulation chamber need not resemble that traditional handicraft requires height (1.35g/cm
3-1.40g/cm
3), can only need be concentrated into 1.05g/cm
3-1.10g/cm
3Get final product, this just can reduce concentration time, reduces the energy consumption when concentrating greatly, has shortened the production cycle.
Get above-mentioned granule and add the two dimensional motion mixer, add total amount and should not surpass 2/3 of mixer total capacity, start mixer and carry out always mixing, always doing time can not be less than 15 minute.Total back granule that mixes is with clean disinfectant container splendid attire, and seals, weighing, and sampling detects, and the packing operation is carried out capsule charge in transfer after the assay was approved.
The present invention's beneficial effect compared with the prior art is that existing technology is binding agent by utilization spray drying one-step palletizing technology with the medicinal liquid, medicated powder is blown afloat, be bonded together with medicinal liquid, directly make the dried granule of big or small uniformity, recharge capsule, the product of Sheng Chaning like this, production cycle shortens greatly, compares with former technology wet granulation, produces originally a collection ofly to be mixed into outsourcing from extractum and medicated powder and to finish and take 8 days at least, only needed just can finish in 2 days now, production efficiency improves greatly; And the capsule content uniformity is homogeneous very, and uniformity of dosage units is very good.
The present invention is applicable to the preparation of two yellow antiphlogistic capsules.
Description of drawings
Accompanying drawing is the process chart of the two yellow antiphlogistic capsule preparations of the present invention
The specific embodiment
The technical process of the two yellow antiphlogistic capsule preparations of the present invention is:
1, pulverizes
Get Radix Scutellariae 257.1g and be ground into fine powder;
2, decoction-extraction Radix Scutellariae decoction liquor
(1) decocts for the first time: take by weighing Radix Scutellariae 171.5g and add multi-function extractor, add the water of about 10 times of medical material amounts, be heated to and boil, decocted 3 hours, take out decoction liquor.
(2) decoct for the second time: the medicinal residues that decoct add the water of about 10 times of medical material amounts for the first time, are heated to and boil, and decoct 1 hour, take out decoction liquor.
(3) decoct for the third time: the medicinal residues that decoct add the water of about 10 times of medical material amounts for the second time, are heated to and boil, and decoct 0.5 hour, take out decoction liquor.
(4) filter: merge three times decoction liquor, decoction liquor is filtered with 200 order stainless steel filtering nets.
3, alcohol reflux-extraction Radix Berberidis extracting solution
(1) reflux, extract, for the first time: take by weighing Radix Berberidis 1285.7g by prescription and add multi-function extractor, add 45% ethanol of about 8 times of medical material amounts, heating and refluxing extraction 1.5 hours is taken out extracting solution.
(2) reflux, extract, for the second time: the medicinal residues that extract add 45% ethanol of about 8 times of medical material amounts for the first time, and heating and refluxing extraction 1.5 hours is taken out extracting solution.
(3) filter: merge secondary raffinate and decoction liquor is filtered with 200 order stainless steel filtering nets.
(4) reclaim ethanol
(5) use the extracting solution of pump delivery of filtered to alcohol distillation column.
(6) open cooling water, slowly open Steam Heating, pressure＜0.1Mpa collects ethanol with cleaning container.
4, concentrate
(1) Radix Scutellariae and Radix Berberidis filtrate merging back are sucked into about 2/3 place of two effect concentration tanks with the vacuum inhalation method, close the charging valve.
(2) open steam valve pressure＜0.1Mpa, keep vacuum, concentrate, be concentrated into and in time replenish medicinal liquid when a certain amount of at 0.04～0.06Mpa.
(3) filtrate to be concentrated into relative density be 1.05g/cm
3～1.10g/cm
3Clear paste, steam off and the vacuum of (50 ℃).
5, spray drying-one-step palletizing
It is indoor as the fluidized bed granulation that adjuvant drops into spray-drying pelleting machine to take by weighing an amount of Radix Scutellariae powder, rises and closes the granulation chamber, sends into the hot blast of 100 ℃ of temperature, makes Radix Scutellariae powder " boiling " preheating.The granulation chamber interior is a porous plate, and going up auxilliaryly has 180 order stainless steel meshs, start blower fan make air by air inlet install after filtration with heat exchanger after, enter the granulation chamber by container bottom again, and making the indoor formation negative pressure of granulating, medicated powder then fluctuates and rolls, and forms " boiling " and preheating and drying.After preheating was qualified, the extract drugs concentrated solution with proportional quantities was sprayed on the granulation chamber and forms droplet through spray nozzle again, and is condensed into the cellular granule with the Radix Scutellariae powder body.Spraying on one side Yi Bian send the hot air drying granule, is vibrated powder at regular intervals and is captured bag.Repeatable operation until the specified amount of medicinal extract concentrated solution has been sprayed, and till the granule of taking a sample to check requirement up to specification, is promptly shut down discharging, granulate, promptly.
6, total mixing
Get above-mentioned granule and add the two dimensional motion mixer, add total amount and should not surpass 2/3 of mixer total capacity, start mixer and carry out always mixing, always doing time can not be less than 15 minute.
7, capsule is filled
8, inspection capsule, polishing
9, aluminum-plastic packaged.
Claims (4)
1. two yellow antiphlogistic capsules and preparation method thereof is characterized in that described method adopts spray drying one-step palletizing technology in granulating process, with the medicinal liquid is binding agent, and medicated powder is blown afloat, and is bonded together with medicinal liquid, directly make the dried granule of big or small uniformity, recharge capsule.
2. two yellow antiphlogistic capsules according to claim 1 and preparation method thereof, it is characterized in that, the method of described one-step palletizing technology is: it is indoor as the fluidized bed granulation that adjuvant drops into spray-drying pelleting machine to take by weighing an amount of Radix Scutellariae powder, rise and close the granulation chamber, send into the hot blast of 100 ℃ of temperature, make Radix Scutellariae powder " boiling " preheating; Start blower fan make air by air inlet install after filtration with heat exchanger after, enter the granulation chamber by container bottom again, and make the indoor formation negative pressure of granulating, medicated powder then fluctuates and rolls, and forms " boiling " and preheating and drying; After preheating was qualified, the extract drugs concentrated solution with proportional quantities was sprayed on the granulation chamber and forms droplet through spray nozzle again, and is condensed into the cellular granule with the Radix Scutellariae powder body; Spraying on one side Yi Bian send the hot air drying granule, is vibrated powder at regular intervals and is captured bag; Repeatable operation is until the specified amount of medicinal extract concentrated solution has been sprayed.
3. two yellow antiphlogistic capsules according to claim 1 and preparation method thereof is characterized in that described one-step palletizing carries out in the fluidized bed granulation chamber of spray-drying pelleting machine, and the granulation chamber interior is a porous plate, go up the auxilliary 180 order stainless steel meshs that have.
4. two yellow antiphlogistic capsules according to claim 1 and preparation method thereof is characterized in that the extract drugs concentrated solution concentration and density that adds in the described one-step palletizing technology is 1.05g/cm
3-1.10g/cm
3
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010114753A CN101766687A (en) | 2010-02-26 | 2010-02-26 | Inflammation diminishing capsules prepared from baical skullcap root and golden thread and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010114753A CN101766687A (en) | 2010-02-26 | 2010-02-26 | Inflammation diminishing capsules prepared from baical skullcap root and golden thread and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101766687A true CN101766687A (en) | 2010-07-07 |
Family
ID=42499888
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010114753A Pending CN101766687A (en) | 2010-02-26 | 2010-02-26 | Inflammation diminishing capsules prepared from baical skullcap root and golden thread and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101766687A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083439A (en) * | 2014-06-19 | 2014-10-08 | 通化万通药业股份有限公司 | Berberis sargentiana Schneid-Scutellaria baicalensis anti-inflammatory drug and preparation method thereof |
| CN105693713A (en) * | 2015-05-28 | 2016-06-22 | 广州牌牌生物科技有限公司 | Berberrubine and baicalein compound and preparing method and application thereof |
| CN114848731A (en) * | 2022-05-19 | 2022-08-05 | 西藏自治区农牧科学院畜牧兽医研究所 | Rumen-bypass Tibetan medicine for treating ruminant gastroenteritis and preparation method thereof |
-
2010
- 2010-02-26 CN CN201010114753A patent/CN101766687A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083439A (en) * | 2014-06-19 | 2014-10-08 | 通化万通药业股份有限公司 | Berberis sargentiana Schneid-Scutellaria baicalensis anti-inflammatory drug and preparation method thereof |
| CN105693713A (en) * | 2015-05-28 | 2016-06-22 | 广州牌牌生物科技有限公司 | Berberrubine and baicalein compound and preparing method and application thereof |
| CN114848731A (en) * | 2022-05-19 | 2022-08-05 | 西藏自治区农牧科学院畜牧兽医研究所 | Rumen-bypass Tibetan medicine for treating ruminant gastroenteritis and preparation method thereof |
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Application publication date: 20100707 |