CN101757162B - Traditional Chinese medicine preparation for treating asthenozoospermia - Google Patents
Traditional Chinese medicine preparation for treating asthenozoospermia Download PDFInfo
- Publication number
- CN101757162B CN101757162B CN2010101077962A CN201010107796A CN101757162B CN 101757162 B CN101757162 B CN 101757162B CN 2010101077962 A CN2010101077962 A CN 2010101077962A CN 201010107796 A CN201010107796 A CN 201010107796A CN 101757162 B CN101757162 B CN 101757162B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine preparation
- radix
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine preparation for treating asthenozoospermia, which comprises the Chinese medicinal herbs in parts by weight: 30 parts of radix paeoniae alba, 20 parts of raspberry, 10 parts of liquorice, 5 parts of centipede, 20 parts of Chinese angelica, 10 parts of corydalis tuber, 100 parts of seed of cowherb, 10 parts of fructus aurantii, 10 parts of fushen and 10 parts of polygala root. Animal experiments and clinical tests prove that the traditional Chinese medicine preparation can improve the sperm motility of men, thereby improving the fertilization rate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of azoospermia.
Background technology
The quickening of rhythm of life, the increase of urbanite's pressure, environmental pollution, microwave radiation or the like reason causes present infertility incidence rate in rising trend, and oneself becomes the global problem that influences couple and family sterility and infertility.Up-to-date medical survey data show that the sterility and infertility incidence rate reaches about 15% at present.The human reproduction of World Health Organization studies studies show that of special Planning Department (WHO-HPR), in the patients with infertility of the whole world, about 1/3rd are caused by the bridegroom's or husband's side, and 1/4th are caused by the wife's side, 1/4th to belong to both sides' healthy reproduction unusual, other have 1/7th for both sides no abnormal, agnogenio.
This shows that the cause of disease of seeking male sterility is the key of curing.Clinically, cause the disease numerous and complicated of male sterility, as genital system infection, prostatosis, sexual dysfunction etc.In recent years, although the treatment research of infertility has been obtained some progress, be treatment achievement mostly, and be applied to all clinical treatment meanss at the male at present and method all has certain limitation or side effect at the women.Class medicines such as gonadal hormone, antibiotic are adopted in the particularly treatment of Western medicine more, and curative effect is relatively poor, toxic and side effects is big, untoward reaction is many etc.
Theory of Chinese medical science has novel viewpoint in this regard.Chinese medicine thinks that the kidney being the origin of congenital constitution, main growth promoter reproduction, and the seed bearing material base of cloudy being of essence of kidney, its normalization is given birth to the sun that process relies on kidney again
The gasification of gas just can make sperm keep normal density, vigor, motility rate.QI and blood is orderly and clearly to be the prerequisite of the normal lifting of negative and positive of kidney, and research data also confirms, in the Chinese medical discrimination typing that sperm concentration, vigor, motility rate reduce, based on the stagnation of liver-QI blood stasis of suffering from a deficiency of the kidney, still with kidney tonifying, essence replenishing, warming YANG and invigorating QI, depressed liver-energy dispersing and QI regulating, the activating blood and resolving stasis and treating azoospermia.
Summary of the invention
The present invention relates to a kind of Chinese medicine preparation for the treatment of azoospermia, it is characterized in that described Chinese medicine preparation made by following bulk drugs: Radix Paeoniae Alba 10-50 part, Fructus Rubi 10-30 part, Radix Glycyrrhizae 5-20 part, Scolopendra 2-10 part; Radix Angelicae Sinensis 10-30 part, Rhizoma Corydalis 5-20 part, Semen Vaccariae 5-20 part, Fructus Aurantii 5-20 part, Poria cum Radix Pini 5-20 part, Radix Polygalae 5-20 part.
Preferably, described Chinese medicine preparation is made by following bulk drugs: 30 parts of the Radix Paeoniae Albas, 20 parts of Fructus Rubies, 10 parts in Radix Glycyrrhizae, 5 parts of Scolopendras, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Corydalis, 10 parts of Semen Vaccariae, 10 parts of Fructus Aurantiis, 10 parts of Poria cum Radix Pinis, 10 parts of Radix Polygalaes.
Described Chinese medicine preparation is a said peroral dosage form on any pharmaceutics.As tablet, oral liquid, capsule, pill, granule etc.
The preparation technology of described Chinese medicine preparation comprises: soaked 30 fens, and decocted 2 times, 60 minutes 40 minutes respectively, collecting decoction, filtering and concentrating to every milliliter of medicinal liquid were equivalent to 1 gram crude drug amount.
Described Chinese medicine preparation can also be used for the treatment of male prostatitis.
Described Chinese medicine preparation can also be used for the treatment of menalgia.
Different with traditional spermatogenesis side, traditional prescription is many to be primary raw material with Herba Epimedii, Semen Cuscutae, Semen Plantaginis etc., and this prescription was mainly used in treatment male prostate pain in the past clinically, and has obtained clinical effectiveness preferably.Find that in therapeutic process this side can also improve the probability of becoming pregnant greatly, the become pregnant mechanism of probability of its raising mainly is by improving prostatic quality, improving testis radioprotective antioxidative ability, the hit rate thereby raising is become pregnant.
There are confidential relation in the power and the health degree of the oxidation resistance of body defense system, the active oxygen that daylight, ultraviolet, ionizing radiation, chemical reaction or the like and body produce has pathology effect widely to body, and the lipid peroxidation that the intravital free radical of people too much causes is relevant with multiple disease.Studies show that in a large number, it is too much relevant that the decline of sperm quality and multiple factor cause intravital free radical, free radical and lipid effect can cause autocatalytic lipid peroxidation, not only cause biomembranous structural deterioration, and cause the film dysfunction, and in the lipid peroxidation chain reaction, also produce new free radical and cytotoxicity product, cause the amplification and the amplification of radical reaction, cause further damage, so antioxidation treatment azoospermia is worth expectation.
Modern pharmacology studies have shown that, the Radix Paeoniae Alba, Fructus Rubi, Radix Glycyrrhizae, Semen Vaccariae, Scolopendra, Radix Polygalae all have tangible antioxidation in the Chinese medicine preparation of the present invention, in the Chinese medicinal formulae WUZIYANZONG WAN, have the people to compare in the antioxidant activity of five kinds of herb ingredients water extraction, Fructus Rubi is the most effective.There is the author to report that the Radix Paeoniae Alba can treat infertile evident in efficacy that the relevant antisperm antibody positive causes, because the antisperm antibody positive patient easily makes agglutination of spermatozoa, reduce its mobility, thereby influence the conveying of sperm, hinder the combination of sperm and ovum, thereby cause sterile.Also have the author to report that Fructus Rubi is rich in various trace elements such as zinc, selenium, manganese and vitamin E, C etc., can improve testicular spermatogenic function and sperm motility function, the Fructus Rubi polysaccharide can also reduce hypothalamus LHRH and gonad estradiol level, the rising testosterone levels.A lot of infertile patients often are associated with prostatitis, and the Radix Paeoniae Alba, Radix Glycyrrhizae, Semen Vaccariae, Scolopendra all have obvious analgesic effect, add that Radix Polygalae can improve sleep, and the inhibition anxiety may also be its raising one of mechanism of probability of becoming pregnant.
It is worthy of note that the pharmacological action of Chinese medicine compound is very complicated multielement participation process, the clear and definite detailed mechanism of action of Chinese medicine preparation of the present invention awaits further to further investigate.
The specific embodiment
Embodiment 1
1 Fructus Rubi of the Radix Paeoniae Alba 30 gram Scolopendras, 20 gram Radix Glycyrrhizaes, 10 grams
More than 4 the flavor, directly the pulverizing, sieve, add appropriate amount of auxiliary materials, add refined honey and prepare big honeyed pills, perhaps
More than 4 flavors, hot-water soak 30 minutes decocted twice with 60 minutes, 40 minutes respectively, collecting decoction filters, and concentrates, and can prepare oral liquid, or adds appropriate amount of auxiliary materials and prepare tablet, capsule, granule.
Embodiment 2
1 Fructus Rubi of the Radix Paeoniae Alba 50 gram Scolopendras, 20 gram Radix Glycyrrhizaes, 10 grams
More than 4 the flavor, directly the pulverizing, sieve, add appropriate amount of auxiliary materials, add refined honey and prepare big honeyed pills, perhaps
More than 4 flavors, hot-water soak 30 minutes decocted twice with 60 minutes, 40 minutes respectively, collecting decoction filters, and concentrates, and can prepare oral liquid, or adds appropriate amount of auxiliary materials and prepare tablet, capsule, granule.
Embodiment 3
1 Fructus Rubi of the Radix Paeoniae Alba 30 gram Scolopendras, 20 gram Radix Angelicae Sinensis, 20 gram Radix Glycyrrhizaes, 10 gram Rhizoma Corydalis, 10 gram Semen Vaccariae, 10 gram Fructus Aurantiis, 10 gram Poria cum Radix Pinis, 10 gram Radix Polygalaes, 10 grams
More than 10 the flavor, directly the pulverizing, sieve, add appropriate amount of auxiliary materials, add refined honey and prepare big honeyed pills, perhaps
More than 10 flavors, hot-water soak 30 minutes decocted twice with 60 minutes, 40 minutes respectively, collecting decoction filters, and concentrates, and can prepare oral liquid, or adds appropriate amount of auxiliary materials and prepare tablet, capsule, granule.
Below further set forth the beneficial effect of Chinese medicine preparation of the present invention by the test example.
Test example 1
1 material and method
1.1 animal origin: adult male SD rats is used in experiment, available from Medical School of Peking University zoopery center, between the body weight 200-250g.
1.2 animal grouping and processing: after 10 SD rat adaptabilities raised for 1 week, extract 10 at random out and put to death immediately as normal group.All the other 70 are given Tripterygium glycosides (GTW) (home, Zhejiang pharmaceutcal corporation, Ltd product) 20mg.kg.d and irritate stomach, after 30 days, randomly draw 10 as the modeling group, put to death immediately.Surplus 60 be divided into 3 groups more at random: promptly of the present invention group, five son groups and matched groups, 20 every group.Of the present invention group: give Chinese medicine preparation of the present invention (Drug Manufacturing Room of General Hospital of Beijing Military Command preparation) 20mL.kg.d and irritated stomach 30 days, and give normal diet; Five son groups: give five-seed Yanzong sheet (making water preparation after wearing into powder, Beijing Tongrentang product) 1.2g.kg.d and irritated stomach 30 days, and give normal diet; Matched group: only give normal diet, will not any medicine.During the rat experiment, except experiment medicine difference, food, drinking-water, experimental situation etc. are all identical, and raising is all put to death after January immediately.
1.3 semen quality detects: after rat is put to death immediately, getting the bilateral epididymis fast shreds, put into 2 milliliters of 37 ℃ of normal saline, put 37 ℃ of calorstats interior 30 minutes, get one of suspension and average as the parameter of rat sperm quality in the colored sperm quality detection system detection of WL-9000 mighty force, leading indicator is a level sperm and sperm motility rate, wherein motility of sperm is 4 grades: a is that sperm motility is good, linearly motion; B is that sperm motility is more active; The c sperm motility is slow, spins in the original place; D is no activity, and a+b is effective sperm motility rate.
1.4 statistical procedures: test data adopts the SPSS10.0 statistical software to analyze, and measurement data compares with the T check between group.
2 results
Case has 5 rats dead in therapeutic process 2.1 come off, and wherein five son groups are 3, and of the present invention group 2, the cause of death is not clear.
2.2 a level sperm of modeling group and sperm motility rate and normal group relatively, all obviously descend, difference has significance meaning (P＜0.01); The a level sperms of of the present invention group and five son groups and sperm motility rate and matched group relatively all obviously improve (P＜0.01), and of the present invention group and five son groups compare, and a level sperm and sperm motility rate do not have obvious change (P＞0.05).See Table 1
Table 1 computer is to the influence of male rat semen quality
Compare with matched group,
*P＜0.05,
*P＜0.01
Test example 2
1 clinical data
All case is all gone to a doctor with infertility.By the WHO diagnostic criteria: live together and do not educate more than 1 year, a level sperm＜25%, and a+b level sperm＜50% are azoospermia.This group is totally 120 routine patients, age 25-43 year, average 32.6 years old; Course of disease 1-14, average 3.8 years.Azoospermia does not belong to range of observation.Whole cases all get rid of urogenital infections and karyotype is unusual.
2 Therapeutic Method
Adopt Chinese medicine preparation of the present invention,, treated altogether 3 months by normal spermatogenic cycle.Stop the other medicines treatment during the treatment, wine for giving off smoking and overtired, normality life.After three months, by ascetic 3-7 days requirement, look into seminal fluid continuously 3 times, detect with the colored sperm quality detection system of WL-9000 mighty force, leading indicator is a level sperm and sperm motility rate, and wherein motility of sperm is 4 grades: a is that sperm motility is good, linearly motion; B is that sperm motility is more active; The c sperm motility is slow, spins in the original place; D is no activity, and a+b+c is effective sperm motility rate.Get its meansigma methods as observation index.Confirm to become pregnant and be as the criterion with the department of obstetrics and gynecology diagnosis.Statistical method adopts own control t check.
3 results
After treatment, patient a level motility of sperm and a+b level motility of sperm and sperm motility rate (a+b+c) all have clear improvement, and be relatively preceding with treatment, difference has the meaning (P＜0.01) of significance, 38 examples of becoming pregnant account for 31.7%, point out Chinese medicine preparation treatment azoospermia of the present invention to have good efficacy.See Table 2
Table 2 Chinese medicine preparation treatment of the present invention azoospermia observation of curative effect
It is relatively preceding with treatment,
*P＜0.05,
*P＜0.01
In addition, Chinese medicine preparation of the present invention also is used for the treatment of prostatitis, menalgia clinically.Clinical observation has definite curative effect.
Claims (4)
1. Chinese medicine preparation for the treatment of azoospermia, it is characterized in that described Chinese medicine preparation made by following bulk drugs: Radix Paeoniae Alba 10-50 part, Fructus Rubi 10-30 part, Radix Glycyrrhizae 5-20 part, Scolopendra 2-10 part, Radix Angelicae Sinensis 10-30 part, Rhizoma Corydalis 5-20 part, Semen Vaccariae 5-20 part, Fructus Aurantii 5-20 part, Poria cum Radix Pini 5-20 part, Radix Polygalae 5-20 part.
2. the Chinese medicine preparation of treatment azoospermia as claimed in claim 1, it is characterized in that described Chinese medicine preparation made by following bulk drugs: 30 parts of the Radix Paeoniae Albas, 20 parts of Fructus Rubies, 10 parts in Radix Glycyrrhizae, 5 parts of Scolopendras, 20 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Corydalis, 10 parts of Semen Vaccariae, 10 parts of Fructus Aurantiis, 10 parts of Poria cum Radix Pinis, 10 parts of Radix Polygalaes.
3. the Chinese medicine preparation of treatment azoospermia as claimed in claim 2 is characterized in that described Chinese medicine preparation is a said peroral dosage form on any pharmaceutics.
4. as the Chinese medicine preparation of arbitrary described treatment azoospermia among the claim 1-3, the preparation technology of described Chinese medicine preparation comprises: soaked 30 minutes, decocted 2 times with 60 minutes, 40 minutes respectively, collecting decoction, filtering and concentrating to every milliliter of medicinal liquid are equivalent to 1 gram crude drug amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101077962A CN101757162B (en) | 2010-02-05 | 2010-02-05 | Traditional Chinese medicine preparation for treating asthenozoospermia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101077962A CN101757162B (en) | 2010-02-05 | 2010-02-05 | Traditional Chinese medicine preparation for treating asthenozoospermia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101757162A CN101757162A (en) | 2010-06-30 |
| CN101757162B true CN101757162B (en) | 2011-11-09 |
Family
ID=42488644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101077962A Expired - Fee Related CN101757162B (en) | 2010-02-05 | 2010-02-05 | Traditional Chinese medicine preparation for treating asthenozoospermia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101757162B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565993B (en) * | 2013-11-11 | 2014-12-10 | 王纯治 | Traditional Chinese medicine prescription for treating prostatitis |
| CN109645497A (en) * | 2018-12-28 | 2019-04-19 | 丽睿客信息科技（北京）有限公司 | A kind of composition and preparation method thereof improving male fertility |
-
2010
- 2010-02-05 CN CN2010101077962A patent/CN101757162B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101757162A (en) | 2010-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103721131B (en) | A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN101744924B (en) | Multiple-effect Chinese herbal medicine compound of bacterial diseases of turbot | |
| CN109645497A (en) | A kind of composition and preparation method thereof improving male fertility | |
| CN101711848B (en) | Chinese medicinal composition capable of adjunctively treating tumour | |
| CN104940659B (en) | Treat the alimentation composition of male infertility infertility or forefront adenoncus | |
| CN107048386A (en) | A kind of sexual function adjusts health food | |
| CN101757162B (en) | Traditional Chinese medicine preparation for treating asthenozoospermia | |
| CN104223297B (en) | A kind of schisandra chinensis health-care oral liquid of slow down aging and preparation method thereof | |
| CN102335394A (en) | Chinese medicinal composition for treating cervical erosion and preparation method thereof | |
| CN102423335A (en) | A pharmaceutical composition for treating sexual impotence and premature ejaculation, and its preparation method | |
| CN105250556A (en) | Traditional Chinese medicine drug for treating polycystic ovarian syndrome | |
| CN101485784B (en) | Chinese medicament preparation for treating male infertility, aspermia and asthenospermia | |
| CN103191399A (en) | Traditional Chinese medicine composition for treating bronchial asthma in acute-outbreak period | |
| CN104888137B (en) | A kind of pharmaceutical preparation for treating polycystic ovary syndrome | |
| CN103550702A (en) | Traditional Chinese medicine composition for cerebral arterial thrombosis | |
| CN103919895B (en) | The Chinese medicinal liquor of a kind of the intestines and stomach coordinating, treatment constipation | |
| CN104738629A (en) | Health food with functions of lubricating intestines and relaxing bowels | |
| CN104605051A (en) | Double hemp-folium cortex eucommiae tea and preparing method thereof | |
| CN104352669B (en) | A kind of application of Chinese medicine in weak sperm disease is treated | |
| CN107213426A (en) | Treat Chinese patent drug of mammary gland disease and preparation method thereof | |
| CN102579795B (en) | Application of anti-ageing Chinese medicinal composition in preparing medicament for improving male reproductive function | |
| Kumari et al. | Medicinal plants used in women's health problems | |
| CN107325940A (en) | A kind of health liquor of tonifying kidney and strengthening yang and preparation method thereof | |
| Gupta | EFFECT OF TRAYANTHYADI KASHAYA IN PCOS-A CASE REPORT |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20111109 Termination date: 20140205 |