CN1017527B - 旋光的氧代异二氢氮茚基衍生物的制备方法 - Google Patents
旋光的氧代异二氢氮茚基衍生物的制备方法Info
- Publication number
- CN1017527B CN1017527B CN88101200A CN88101200A CN1017527B CN 1017527 B CN1017527 B CN 1017527B CN 88101200 A CN88101200 A CN 88101200A CN 88101200 A CN88101200 A CN 88101200A CN 1017527 B CN1017527 B CN 1017527B
- Authority
- CN
- China
- Prior art keywords
- formula
- optically active
- compound
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 208000021156 intermittent vascular claudication Diseases 0.000 description 1
- 208000023589 ischemic disease Diseases 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910001950 potassium oxide Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical compound CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 208000004043 venous thromboembolism Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- 229960000317 yohimbine Drugs 0.000 description 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878705601A GB8705601D0 (en) | 1987-03-10 | 1987-03-10 | Oxo-isoindolinyl derivatives |
| GB8705601 | 1987-03-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN88101200A CN88101200A (zh) | 1988-10-26 |
| CN1017527B true CN1017527B (zh) | 1992-07-22 |
Family
ID=10613660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN88101200A Expired CN1017527B (zh) | 1987-03-10 | 1988-03-09 | 旋光的氧代异二氢氮茚基衍生物的制备方法 |
Country Status (29)
| Country | Link |
|---|---|
| JP (1) | JPH0759555B2 (ru) |
| KR (1) | KR880011096A (ru) |
| CN (1) | CN1017527B (ru) |
| AT (1) | AT392068B (ru) |
| AU (1) | AU605253B2 (ru) |
| BE (1) | BE1003280A3 (ru) |
| CH (1) | CH675419A5 (ru) |
| DE (1) | DE3807595A1 (ru) |
| DK (1) | DK168568B1 (ru) |
| ES (1) | ES2006361A6 (ru) |
| FI (1) | FI93725C (ru) |
| FR (1) | FR2612185B1 (ru) |
| GB (2) | GB8705601D0 (ru) |
| GR (1) | GR1000515B (ru) |
| HU (1) | HU201011B (ru) |
| IE (1) | IE60565B1 (ru) |
| IL (1) | IL85651A (ru) |
| IT (1) | IT1227787B (ru) |
| MY (1) | MY103898A (ru) |
| NL (1) | NL8800575A (ru) |
| NO (1) | NO174666C (ru) |
| NZ (1) | NZ223805A (ru) |
| PH (1) | PH26254A (ru) |
| PT (1) | PT86933B (ru) |
| SE (1) | SE500710C2 (ru) |
| SU (1) | SU1731046A3 (ru) |
| UA (1) | UA12840A1 (ru) |
| YU (1) | YU46565B (ru) |
| ZA (1) | ZA881686B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400633C (zh) * | 2006-03-30 | 2008-07-09 | 中国日用化学工业研究院 | 一种手洗餐具洗涤剂及制备方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| IT1256450B (it) * | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2154525A1 (de) * | 1970-11-05 | 1972-06-15 | Carlo Erba S.P.A., Mailand (Italien) | Isoindolinderivate und Verfahren zu ihrer Herstellung |
| GB1344663A (en) * | 1970-11-10 | 1974-01-23 | Erba Carlo Spa | Isoindoline compounds |
| US4010274A (en) | 1973-07-27 | 1977-03-01 | Carlo Erba | Isoindoline derivatives having platelet anti-aggregating activity |
| JPS516959A (en) * | 1974-07-04 | 1976-01-20 | Wakamoto Pharma Co Ltd | Isoindorinjudotaino seizohoho |
| US4400520A (en) * | 1980-09-10 | 1983-08-23 | Hisamitsu Pharmaceutical Co., Inc. | Novel process for preparing isoindoline derivatives |
| IT1201408B (it) * | 1985-03-22 | 1989-02-02 | Montedison Spa | Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi |
| JPH07120969B2 (ja) * | 1989-03-30 | 1995-12-20 | クラリオン株式会社 | スペクトラム拡散変調装置 |
-
1987
- 1987-03-10 GB GB878705601A patent/GB8705601D0/en active Pending
-
1988
- 1988-02-22 PH PH46539A patent/PH26254A/en unknown
- 1988-03-04 CH CH826/88A patent/CH675419A5/de not_active IP Right Cessation
- 1988-03-07 AT AT0058988A patent/AT392068B/de not_active IP Right Cessation
- 1988-03-07 AU AU12679/88A patent/AU605253B2/en not_active Ceased
- 1988-03-07 FR FR888802872A patent/FR2612185B1/fr not_active Expired - Lifetime
- 1988-03-07 IL IL85651A patent/IL85651A/xx not_active IP Right Cessation
- 1988-03-08 HU HU881124A patent/HU201011B/hu not_active IP Right Cessation
- 1988-03-08 YU YU46788A patent/YU46565B/sh unknown
- 1988-03-08 NL NL8800575A patent/NL8800575A/nl not_active Application Discontinuation
- 1988-03-08 ES ES8800684A patent/ES2006361A6/es not_active Expired
- 1988-03-08 GR GR880100137A patent/GR1000515B/el unknown
- 1988-03-08 DE DE3807595A patent/DE3807595A1/de not_active Withdrawn
- 1988-03-08 KR KR1019880002373A patent/KR880011096A/ko not_active Application Discontinuation
- 1988-03-08 IT IT8819683A patent/IT1227787B/it active
- 1988-03-09 ZA ZA881686A patent/ZA881686B/xx unknown
- 1988-03-09 JP JP63055954A patent/JPH0759555B2/ja not_active Expired - Lifetime
- 1988-03-09 DK DK128988A patent/DK168568B1/da not_active IP Right Cessation
- 1988-03-09 SE SE8800846A patent/SE500710C2/sv unknown
- 1988-03-09 GB GB8805631A patent/GB2204579B/en not_active Expired - Lifetime
- 1988-03-09 NO NO881055A patent/NO174666C/no unknown
- 1988-03-09 BE BE8800258A patent/BE1003280A3/fr not_active IP Right Cessation
- 1988-03-09 NZ NZ223805A patent/NZ223805A/en unknown
- 1988-03-09 UA UA4355276A patent/UA12840A1/uk unknown
- 1988-03-09 PT PT86933A patent/PT86933B/pt not_active IP Right Cessation
- 1988-03-09 FI FI881075A patent/FI93725C/fi not_active IP Right Cessation
- 1988-03-09 CN CN88101200A patent/CN1017527B/zh not_active Expired
- 1988-03-09 SU SU884355276A patent/SU1731046A3/ru active
- 1988-03-10 MY MYPI88000246A patent/MY103898A/en unknown
- 1988-08-07 IE IE64888A patent/IE60565B1/en not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400633C (zh) * | 2006-03-30 | 2008-07-09 | 中国日用化学工业研究院 | 一种手洗餐具洗涤剂及制备方法 |
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| C19 | Lapse of patent right due to non-payment of the annual fee | ||
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