CN101721387B - Calcium carbonate effervescing agent and preparation method thereof - Google Patents
Calcium carbonate effervescing agent and preparation method thereof Download PDFInfo
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- CN101721387B CN101721387B CN2009102601026A CN200910260102A CN101721387B CN 101721387 B CN101721387 B CN 101721387B CN 2009102601026 A CN2009102601026 A CN 2009102601026A CN 200910260102 A CN200910260102 A CN 200910260102A CN 101721387 B CN101721387 B CN 101721387B
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- calcium carbonate
- agent
- effervescent
- poloxamer
- acid
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 139
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims abstract description 70
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title description 10
- 229920001983 poloxamer Polymers 0.000 claims abstract description 28
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229960000502 poloxamer Drugs 0.000 claims abstract description 25
- 238000000034 method Methods 0.000 claims abstract description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 20
- 239000004088 foaming agent Substances 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 11
- 235000015165 citric acid Nutrition 0.000 claims description 10
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 7
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
- 239000001630 malic acid Substances 0.000 claims description 7
- 235000011090 malic acid Nutrition 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical group OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 239000007938 effervescent tablet Substances 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 235000013355 food flavoring agent Nutrition 0.000 claims description 2
- 239000001530 fumaric acid Substances 0.000 claims description 2
- 235000011087 fumaric acid Nutrition 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 238000000465 moulding Methods 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 238000005187 foaming Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 7
- 238000005352 clarification Methods 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 description 19
- 239000000047 product Substances 0.000 description 15
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
- 239000011575 calcium Substances 0.000 description 14
- 229910052791 calcium Inorganic materials 0.000 description 14
- 239000002552 dosage form Substances 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 229940099690 malic acid Drugs 0.000 description 6
- 238000012856 packing Methods 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
- 238000010668 complexation reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- -1 calcium carbonate compound Chemical class 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 208000002310 Achlorhydria Diseases 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- KVSINRZVPDJZGE-UHFFFAOYSA-N [Ca].[Ca].[Ca].C(CC(O)(C(=O)O)CC(=O)O)(=O)O Chemical compound [Ca].[Ca].[Ca].C(CC(O)(C(=O)O)CC(=O)O)(=O)O KVSINRZVPDJZGE-UHFFFAOYSA-N 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000001362 calcium malate Substances 0.000 description 1
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 description 1
- 229940016114 calcium malate Drugs 0.000 description 1
- 235000011038 calcium malates Nutrition 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- HBYOLNPZXLHVQA-UHFFFAOYSA-J dicalcium dicarbonate Chemical compound [Ca+2].[Ca+2].[O-]C([O-])=O.[O-]C([O-])=O HBYOLNPZXLHVQA-UHFFFAOYSA-J 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229940116298 l- malic acid Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940099076 maalox Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention provides a calcium carbonate effervescing agent, which comprises an effective amount of poloxamer. The calcium carbonate effervescing agent which comprises the effective amount of poloxamer has good stability; and at the same time, the calcium carbonate effervescing agent prolongs the time of keeping clarification after being effervesced in water. The invention also provides a method for preparing the calcium carbonate effervescing agent.
Description
Technical field:
The present invention relates to the preparation method of a kind of calcium carbonate effervescing agent and this calcium carbonate effervescing agent, belong to the technical field of pharmaceutical preparation.
Background technology:
Effervescent is a kind of relatively new dosage form, be with the general formulation difference, must contain soda acid system foaming agent in its preparation prescription, acid foaming agent is generally the organic acid such as citric acid, tartaric acid, malic acid, the alkalescence foaming agent is generally subcarbonate, such as sodium carbonate, sodium bicarbonate, potassium bicarbonate etc.After effervescent is with the different approaches administration, run into body fluid or water moistening after, then acid and alkaline foaming agent immediate response produces a large amount of carbon dioxides, gas is overflowed from dosage form, makes effervescent form countless holes.Make water enter fast effervescent, promote the further chain reaction of soda acid foaming agent, a large amount of gases of generation form certain pressure from dosage form, and whole effervescent is thoroughly burst apart, and reach the purpose that medicine dissolution discharges.Because gas acutely discharges from dosage form, is similar to the boiling of water in liquid, therefore be referred to as effervescent.
Calcium carbonate is that present cost/effectiveness is the highest, toxicity is minimum, the putative ideal raw material of replenishing the calcium.Calcium carbonate is widely used in European and American countries as calsium supplement, and the launch of various dosage forms is arranged, such as conventional tablet, and capsule, granule, powder, oral solution, effervescent etc.
Calcium carbonate effervescing agent is dosage form more excellent in the Maalox Antacid, the ordinary calcium carbonate calcium supplementing product mainly relies on to be taken rear calcium carbonate stomach function regulating acid reaction and generates ionic calcium and absorb, can consume a large amount of gastric acid, very unfavorable to the absorption of calcium to achlorhydria person or old people, and react insufficient and can affect degree of absorption, long-term taking also can cause dyspepsia and abdominal distention.Calcium carbonate is a kind of weakly alkaline carbonate, utilize the soda acid foaming agent system to make effervescent calcium carbonate, when taking calcium carbonate effervescing agent is dropped in the warm water, citric acid in the preparation, the acid foaming agent such as malic acid and calcium carbonate reaction become insoluble calcium carbonate the calcium citrate of solubility, the calcium malate ionic calcium has increased the absorption of calcium, has improved bioavailability.The untoward reaction of having avoided simultaneously the gastric acid reaction to cause.
Calcium carbonate effervescing agent is a lot of dosage form of advantage in the calcium carbonate product, but still there is a general problem at present in this dosage form, namely because the moisture absorption very easily such as the acid foaming agent citric acid that generally uses in the calcium carbonate effervescing agent, malic acid, calcium carbonate can react with citric acid, malic acid gradually in the calcium carbonate effervescing agent of the moisture absorption, reacted calcium ion and citric acid etc. form insoluble complex gradually, cause being muddy state after the effervescent bath after the moisture absorption, can not form initial settled solution, can affect the content of solubility calcium, and then affect absorption and the utilization of calcium.
Therefore, in order to prevent that the calcium carbonate effervescing agent moisture absorption from producing above-mentioned phenomenon, the packing of general calcium carbonate effervescing agent all need strictly prevent the moisture absorption, and the placement condition avoids super-humid conditions, even like this, after long-time the placement, sometimes still be difficult to avoid product more or less to absorb a certain amount of moisture, cause the precipitation and turbidity phenomenon occurring behind the product effervescent, affect the absorption of calcium, simultaneously, also cause the effect duration of this product to shorten.
The effervescent of calcium carbonate has some launch, but the problems referred to above for calcium carbonate effervescing agent still do not have good solution, be still by having the packing of anti-moisture absorption, general moisture absorption degree such as reduction products such as clad aluminum foil bag packings, although the method can solve the stability problem that the moisture absorption is brought at product in certain effect duration, but sometimes still be difficult to avoid the moisture absorption probability of product, damaged such as the packing of product, open and do not take timely behind the bag etc.In addition, the adjuvants such as the filler that adds in calcium carbonate effervescing agent are generally selected the adjuvant that is difficult for the moisture absorption, such as sucrose, and lactose etc., but the adding of these adjuvants can not highly effectively address the above problem.
Therefore, for after the long-term placement, be difficult for the moisture absorption in the art, further be the calcium carbonate effervescing agent that still keeps clarifying behind the effervescent and have demand.
Summary of the invention:
I add some suitable surfactants keep clear state afterwards to prolong calcium carbonate effervescing agent in bath time at company's research worker expectation, and in fact really played certain effect, do not add the calcium carbonate effervescing agent of poloxamer after bath, if approximately do not take in 30 minutes, can engender turbid phenomenon, be citric acid and calcium carbonate and in solution, formed gradually insoluble citric acid tricalcium precipitation, just began to occur turbid phenomenon nearly in 60 minutes and added after the effervescent bath of poloxamer.
In the above-mentioned research process, the stability problem that the research worker accident has been found described calcium carbonate effervescing agent also accident has obtained solution, the adding of poloxamer has not only prolonged the time that solution keeps clear state behind the effervescent, the more important thing is after the calcium carbonate effervescing agent that adds the effective dose poloxamer is placed obviously longer time effervescent still to be settled solution.
The invention provides a kind of calcium carbonate effervescing agent, described calcium carbonate effervescing agent stable fine, furtherly, described calcium carbonate effervescing agent is placed the obviously longer time, still is settled solution behind the effervescent.Described calcium carbonate effervescing agent is realized as follows:
Described calcium carbonate effervescing agent contains the poloxamer of effective dose.Poloxamer is selected from PLURONICS F87, and 237,338,407 or its any combination.Described effervescent also contains acid foaming agent and optional filler and correctives.The addition of poloxamer is preferably 20～30% of acid foaming agent total amount.Described percentage ratio calculates based on weight.
Described acid foaming agent is selected from citric acid, malic acid, tartaric acid, fumaric acid or its any combination; Filler is selected from lactose, sucrose, sorbitol, mannitol or its any combination; Flavoring agent is selected from various sweeting agents such as aspartame, stevioside and various essence.
Described calcium carbonate effervescing agent comprises folk prescription or the compound recipe effervescent of calcium carbonate.Described calcium carbonate compound recipe effervescent removes and contains calcium carbonate, and also can comprise and contain various vitamin and multiple element, such as vitamin A, B, C, D, E, K, ferrum, zinc, magnesium, one or more in the phosphorus etc.Described calcium carbonate compound recipe effervescent is not limited only to mentioned component, and it comprises that all contain the compound recipe effervescent of calcium carbonate.The folk prescription of described calcium carbonate or compound recipe effervescent comprise effervescent granule, effervescent tablet or effervescent capsule.
The present invention also provides a kind of method for preparing calcium carbonate effervescing agent, it is that the effective dose poloxamer is mixed with other composition in the effervescent, comprise described poloxamer is fully mixed in advance with acid foaming agent, further comprise mixed granulation and molding, make effervescent granule, effervescent tablet or effervescent capsule.
Find in the stability test, the present invention adds the effervescent of poloxamer and does not add the effervescent comparison of poloxamer, and product stability significantly is improved.The calcium carbonate effervescing agent that will not add poloxamer and adding poloxamer except unlap places 25 ℃ of room temperature, place in relative humidity 60% environment, the present invention adds the calcium carbonate effervescing agent of poloxamer and place the obviously longer time in above-mentioned environment, just occurs the turbidity and precipitation phenomenon after bubbly water is risen.But this invention prolongs the effect duration of product with the stability of improving product, also can play certain help for the untimely situation about taking of unpacking simultaneously.
Unexpectedly, the fine stability problem that has improved calcium carbonate effervescing agent existence in the prior art of the adding of effective dose poloxamer, namely the prior art calcium carbonate effervescing agent is placed through long-term, after bubbly water is risen, can not form the technical problem of settled solution.Its reason is in long-term put procedure, and acid foaming agent and calcium carbonate reaction have also formed insoluble complexation calcium gradually.The stability of calcium carbonate effervescing agent of the present invention is improved, and can reduce the strict demand to packing, thereby has also reached the purpose that reduces packing cost.
The specific embodiment
Embodiment
Further specify the present invention below by embodiment, be convenient to better understand the present invention.Yet scope of the present invention is not limited to these embodiment.Unless stated otherwise, all commercially available acquisitions of all reagent.
Prepare according to the following formulation calcium carbonate effervescent granule:
| Prescription 1 | Prescription 2 | |
| Calcium carbonate | 375g | 375g |
| Lactose | 535g | 535g |
| Citric acid | 425g | 425g |
| L MALIC ACID | 150g | 150g |
| PLURONICS F87 | 143g | |
| Aspartame | 17.5g | 17.5g |
| Essence | In right amount | In right amount |
| Make | 1000 bags | 1000 bags |
Preparation method:
Prescription 1 is with poloxamer and citric acid, and malic acid etc. fully mix, and adds calcium carbonate, lactose, aspartame mix homogeneously.Add an amount of dehydrated alcohol, soft material processed, 20 mesh sieves are granulated, drying, 20 mesh sieve granulate, the spray Fructus Citri Limoniae essence is an amount of, the preparation calcium carbonate effervescent granule.Prescription 2 is not except adding the poloxamer, and other prepare calcium carbonate effervescent granule by the same method with prescription 1.
Place 25 ℃ of temperature with the effervescent granules of prescription 1 and 2 preparations are exposed respectively, place in the environment of relative humidity 60%.With following index, 2 kinds of calcium carbonate effervescing agents of above-mentioned acquisition are investigated:
Index: the clarity of solution behind the effervescent
The clarity of solution has reflected behind the effervescent situation of solubility calcium in the solution behind the effervescent, be muddy state such as solution behind the effervescent, show that part calcium has formed insoluble complexation calcium in preparation, formed insoluble complexation calcium relevant with the product moisture absorption, after the moisture absorption, reaction has partly occured and has formed gradually insoluble complexation calcium in acid foaming agent and calcium carbonate.
Evaluation methodology: be taken at respectively the prescription 1 of placement different time under the above-mentioned condition and the calcium carbonate effervescent granule 1.5g of prescription 2, put among the drinking water 200ml of room temperature, observe the clarity of the fully rear solution of effervescent.
Evaluation result is as follows:
As can be seen from the above results, by the calcium carbonate effervescing agent of the present invention preparation, significantly improve the stability after product is placed, solved the easy moisture absorption that present calcium carbonate effervescing agent exists and cause placing the technical problem of not clarifying behind the product effervescent after a period of time.
As what it will be apparent to those skilled in the art that, can make many modifications and variations of the present invention and do not deviate from its spirit and scope.Specific embodiments described herein only provides in the mode of example, and gamut restriction the present invention of the equivalent that only is awarded together with these claim with claims.
Claims (8)
1. calcium carbonate effervescing agent, it is characterized in that described effervescent contains poloxamer and the acid foaming agent of effective dose, wherein poloxamer and described acid foaming agent fully mix in advance, the addition of described poloxamer is 20～30% of described acid foaming dosage, and described percentage ratio calculates based on weight.
2. the calcium carbonate effervescing agent of claim 1, wherein said poloxamer are selected from PLURONICS F87,237,338 or 407 or its any combination.
3. the calcium carbonate effervescing agent of claim 2, it also contains optional filler and correctives.
4. the calcium carbonate effervescing agent of claim 3, wherein said acid foaming agent is selected from citric acid, malic acid, tartaric acid, fumaric acid or its any combination; Described filler is selected from lactose, sucrose, sorbitol, mannitol or its any combination; Described flavoring agent is selected from aspartame, stevioside, essence or its any combination.
5. each described calcium carbonate effervescing agent of claim 1-4, it comprises folk prescription or the compound recipe effervescent of calcium carbonate.
6. the calcium carbonate effervescing agent of claim 5, it comprises effervescent granule, effervescent tablet or effervescent capsule.
7. the method for preparing calcium carbonate effervescing agent, it comprises that the poloxamer with effective dose fully mixes in advance with acid foaming agent, and the addition of described poloxamer is 20～30% of described acid foaming dosage, and described percentage ratio calculates based on weight.
8. method claimed in claim 7, it further comprises granulates and molding.
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| WO2025222289A1 (en) * | 2024-04-23 | 2025-10-30 | Biovantek | Calcium carbonate formulations and method of treatment of gastroesophageal reflux disease (gerd) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105496983B (en) * | 2016-01-21 | 2018-04-03 | 国药集团汕头金石制药有限公司 | Oyster shell calcium effervescence tablet composition and preparation method thereof |
| CN105640981B (en) * | 2016-01-21 | 2018-09-11 | 国药集团汕头金石制药有限公司 | Oyster shell calcium effervescence tablet composition and preparation method thereof |
| CN107875170B (en) * | 2017-11-10 | 2020-07-07 | 江苏扬新生物医药有限公司 | Calcium carbonate-containing effervescent agent |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130865A (en) * | 1993-09-09 | 1996-09-11 | 杰哈德·盖尔盖伊 | Effervescent granule and its manufacturing method |
| CN101375838A (en) * | 2007-08-31 | 2009-03-04 | 珠海清大弘瑞生物科技有限公司 | Fizzy formulation and preparation method thereof |
-
2009
- 2009-12-24 CN CN2009102601026A patent/CN101721387B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130865A (en) * | 1993-09-09 | 1996-09-11 | 杰哈德·盖尔盖伊 | Effervescent granule and its manufacturing method |
| CN101375838A (en) * | 2007-08-31 | 2009-03-04 | 珠海清大弘瑞生物科技有限公司 | Fizzy formulation and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 侯甲福等.复方氯霉素泡腾胶囊的制备及含量测定.《牡丹江医学院学报》.2006,第27卷(第6期),73－74页. |
| 农药泡腾剂的研究与开发;孙锦程等;《中华卫生杀虫药械》;20091031;第15卷(第5期);351－354 * |
| 复方氯霉素泡腾胶囊的制备及含量测定;侯甲福等;《牡丹江医学院学报》;20061231;第27卷(第6期);73－74页 * |
| 孙锦程等.农药泡腾剂的研究与开发.《中华卫生杀虫药械》.2009,第15卷(第5期),351－354. |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025222289A1 (en) * | 2024-04-23 | 2025-10-30 | Biovantek | Calcium carbonate formulations and method of treatment of gastroesophageal reflux disease (gerd) |
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