CN101708171B - Enteric plant hollow capsule - Google Patents
Enteric plant hollow capsule Download PDFInfo
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- CN101708171B CN101708171B CN200910185990XA CN200910185990A CN101708171B CN 101708171 B CN101708171 B CN 101708171B CN 200910185990X A CN200910185990X A CN 200910185990XA CN 200910185990 A CN200910185990 A CN 200910185990A CN 101708171 B CN101708171 B CN 101708171B
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- capsule
- enteric
- hollow capsule
- plant hollow
- pectin
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- 239000002775 capsule Substances 0.000 title claims abstract description 40
- 239000001814 pectin Substances 0.000 claims abstract description 13
- 235000010987 pectin Nutrition 0.000 claims abstract description 13
- 229920001277 pectin Polymers 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000004014 plasticizer Substances 0.000 claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 238000005189 flocculation Methods 0.000 claims description 8
- 230000016615 flocculation Effects 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 235000010418 carrageenan Nutrition 0.000 claims description 5
- 239000000679 carrageenan Substances 0.000 claims description 5
- 229920001525 carrageenan Polymers 0.000 claims description 5
- 229940113118 carrageenan Drugs 0.000 claims description 5
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 4
- 235000010492 gellan gum Nutrition 0.000 claims description 4
- 239000000216 gellan gum Substances 0.000 claims description 4
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 4
- 229960000367 inositol Drugs 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 239000001508 potassium citrate Substances 0.000 claims description 4
- 229960002635 potassium citrate Drugs 0.000 claims description 4
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 4
- 235000011082 potassium citrates Nutrition 0.000 claims description 4
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 239000003292 glue Substances 0.000 abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 5
- 210000004051 gastric juice Anatomy 0.000 abstract description 5
- 230000000968 intestinal effect Effects 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 238000006243 chemical reaction Methods 0.000 abstract description 3
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- 238000001816 cooling Methods 0.000 abstract description 3
- 238000005520 cutting process Methods 0.000 abstract description 3
- 238000007598 dipping method Methods 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 3
- 238000003756 stirring Methods 0.000 abstract description 3
- 239000003960 organic solvent Substances 0.000 abstract description 2
- 230000009286 beneficial effect Effects 0.000 abstract 2
- 239000000701 coagulant Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 230000005484 gravity Effects 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 description 12
- 239000000463 material Substances 0.000 description 9
- 229920000159 gelatin Polymers 0.000 description 8
- 235000019322 gelatine Nutrition 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 7
- 239000008273 gelatin Substances 0.000 description 7
- 235000011852 gelatine desserts Nutrition 0.000 description 7
- 239000007903 gelatin capsule Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000002702 enteric coating Substances 0.000 description 4
- 238000009505 enteric coating Methods 0.000 description 4
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 3
- 230000032050 esterification Effects 0.000 description 3
- 238000005886 esterification reaction Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 208000034189 Sclerosis Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000576 food coloring agent Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 238000007711 solidification Methods 0.000 description 2
- 230000008023 solidification Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- NAVWVHRQSDHCHD-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;potassium Chemical compound [K].OC(=O)CC(O)(C(O)=O)CC(O)=O NAVWVHRQSDHCHD-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000275012 Sesbania cannabina Species 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229920006335 epoxy glue Polymers 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229920000591 gum Polymers 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- -1 hydroxypropyl Chemical group 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012946 outsourcing Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention relates to an enteric plant hollow capsule which is prepared by a method comprising: firstly adding 60-85% of pectin, 5-20% of plasticizer, 5-10% of coagulant aid and 5-10% of water used for curing agent into a reaction pot; stirring and dissolving at 60-90 DEG C, and obtaining glue stock by filtering and adjusting specific gravity; removing air bubbles and then sending into a capsule production line for the treatment such as dipping in glue, drying, cooling, demoulding, cutting, sheathing, etc. The enteric plant hollow capsule has the disintegration time limit of 3-4h in gastric juice and 30-45min in intestinal juice. Compared with the existing enteric capsule, the enteric plant hollow capsule omits the working procedure of coating, simplifies the technique, and completely uses no organic solvent, thus not only being beneficial to safe production and environmental protection, but also being beneficial to improving the efficiency and reducing the cost.
Description
One, technical field
The present invention relates to a kind of pharmaceutic adjuvant enteric hollow capsule, specifically a kind ofly do not allow disintegrate and want rapid dissolved targeting, vegetal enteric hollow capsule at the human small intestine position the human stomach.
Two, technical background
Enteric hollow capsule (softgel shell) is meant that softgel shell is insoluble in gastric juice, but can be in intestinal juice disintegrate or dissolving and discharge medicine in the capsule, softgel shell also is the main adjuvant of processing medicament capsule preparation.The enteric hollow capsule that uses is the enteric-coating material by the anti-gastric acid of outsourcing after the gelatin machine-shaping at present.Gelatin is earlier with glue after purified water immersion, the swelling, after send the capsule manufacture line through dipping in gum forming, dry solidification, obtaining gelatin Capsules capsule material, carry out enteric coating again in gelatin Capsules capsule material surface and handle back formation enteric hollow capsule capsule material, operations such as dry solidification cooling again, cutting obtain enteric hollow capsule (softgel shell).Described glue is exactly the gelatin after the swelling to be dropped into to heat up in the mixing kettle with water surface activating agent etc. stir, after filtration, remove bubble, obtain sizing material after transferring proportion.
Present enteric hollow capsule mainly is made up of the enteric-coating material and the gelatin of anti-gastric acid.The enteric-coating material of anti-gastric acid mostly is CAP or acrylic resin, and must use ethanol and acetone to make solvent when coating, and solvent evaporates in forming process is on the one hand wasted resource, raised cost, contaminated air, and is residual in addition in softgel shell on the other hand.
The water soluble protein that gelatin is obtained through hydrolysis by the collagen protein in the connective tissues such as the skin of animal, bone, tendon, ligament.Protein is subject to the influence of acid, alkali, and medicated powder acidity or alkalescence that Ruo Qinei fills are stronger, can cause hydrolysis of gelatin Capsules or sclerosis.Practice shows, in storage process, although also in the shelf-life, the quality of capsule also seriously descends, such as sclerosis, embrittlement, easy disintegrating not, serious only remaining a pile powder.In addition, because of the religions belief reason, take as taboos such as Islam, kosher; In recent years epidemic situations such as " bovine spongiform encephalopathy " of Chu Xianing, " foot and mouth disease " again serious impact gelatine enteric Capsules agent market.Other feedstock production capsules that exploitation substitutes gelatin have realistic meaning.So someone just prepares plant hollow capsule with hydroxypropyl emthylcellulose (HPMC) and polysaccharide.But this class capsule can only be at the dissolved plant hollow capsule of the stomach of human body.
Three, summary of the invention
The object of the present invention is to provide a kind of every physicochemical property to meet all that " the new enteric plant hollow capsule of Chinese pharmacopoeia regulation, technical problem to be solved is to select new capsule material and prescription thereof.
The applicant is through years of researches and exploration, and selecting with pectin is raw material, and is aided with firming agent, flocculation aid and suitable plasticizer and directly is processed into enteric plant hollow capsule, and each component has following percentage by weight:
Pectin: 60～85%,
Plasticizer: 5～20%,
Flocculation aid: 5～10%,
Firming agent: 5～10%.
Described pectin is from economic crop and garden crop side-product, and as sunflower plate, megasse, a kind of colloid macromole that obtains is extracted in processing in peel of Citrus reticulata Blanco, Fericarpium Citri Limoniae, Fructus Citri grandis skin, the Exocarpium Citrulli etc.Pectin is a kind of polymer of galacturonic acid.(hydrogen atom COOH) is methyl substituted and esterification to some carboxyl in molecule in the galacturonic acid, big or small pectin according to esterification degree is divided into low methoxyl pectin (esterification degree＜50% also claims hypo-methoxy pectin) and high-esterpectin (claiming hyper-methoxy pectin again).Experiment shows that these two kinds of pectin all can use in this application.Because pectin is taken from plant, so claim enteric plant hollow capsule.
Described plasticizer is selected from water-soluble alcohol, as sorbitol, glycerol, Polyethylene Glycol, inositol, maltose alcohol, and a kind of or both above mixed plasticizers in the polyvinyl alcohol etc.
Described flocculation aid is selected from potassium citrate or sodium citrate or potassium chloride or calcium chloride.Optimization citric acid potassium.
Described firming agent is selected from plant gum, as one or more epoxy glues in arabic gum or sesbania gum or carrageenan or gellan gum or xanthan gum or alginate jelly or the agar etc.Preferred plant glue is or/and microbiological gum, as carrageenan or/and gellan gum or/and xanthan gum etc.
Pectin, firming agent, flocculation aid and plasticizer are the key components of this enteric plant hollow capsule.In addition, the same with processing gelatin Capsules, also can add food coloring according to actual needs or/and opacifier titanium dioxide.
The preparation of this enteric plant hollow capsule also comprises the preparation of sizing material and the processing of softgel shell.Will pectin and water drop into that heated and stirred dissolving back adds firming agent, flocculation aid and plasticizer in the mixing kettle, the after-filtration that stirs, remove bubble, transfer proportion (being concentration of pectin), send capsule manufacture line processing softgel shell then.
The experiment of this enteric plant hollow capsule shows that quality index can meet " Chinese pharmacopoeia enteric hollow capsule standard fully, in gastric juice, do not dissolve, in intestinal juice, dissolve, index was as follows after testing: gastric juice 3---4 disintegration hour, 30～45 minutes disintegrations of intestinal juice, " Chinese pharmacopoeia regulation enteric hollow capsule gastric juice disintegration＞2 hour, intestinal juice disintegration＜1 hour.
This capsule is compared with existing enteric coated capsule, has saved the coating operation, work simplification, and fully not with an organic solvent, both helped safety in production, protection environment, help raising the efficiency, reducing cost.
Four, the specific embodiment
Below the present invention is described in further detail, and provide the specific embodiment.
Embodiment 1, one or more mix 6kg, purified water 60kg to get low methoxyl pectin 30kg, carrageenan or gellan gum 3kg, potassium citrate 3kg, polyvinyl alcohol, sorbitol, glycerol, Polyethylene Glycol, inositol, maltose alcohol.
Production equipment is with existing identical with the manufacturing of gelatin Capsules.Pour low methoxyl pectin and water into the reaction pot heated and stirred, dissolving, add firming agent again, flocculation aid and plasticizer, 60 ℃-90 ℃ of the recirculated water water temperatures of reaction pot, stirred 2-4 hour, fully glue is filtered with 150 purpose filter bags in the dissolving back, glue is stored in the heat-preserving container, see proportion, regulate gelatin concentration, different institutes add versicolor food coloring and add a certain amount of opacifier titanium dioxide etc. according to user's demand, leave standstill insulation again except that bubble, put into again on the capsule manufacture line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing needs lettering lettering etc. behind fit.
Embodiment 2, get high-esterpectin 30kg, carrageenan or xanthan gum 2kg, one or more mix 4kg, purified water 60kg potassium citrate 2kg, polyvinyl alcohol, sorbitol, glycerol, Polyethylene Glycol, inositol, maltose alcohol.Its production method is with embodiment 1.
Claims (1)
1. an enteric plant hollow capsule comprises pectin and adjuvant, it is characterized in that: each component has following percentage by weight:
Pectin: 60～85%,
Plasticizer: 5～20%,
Flocculation aid: 5～10%,
Firming agent: 5～10%;
Described plasticizer is selected from sorbitol, glycerol, Polyethylene Glycol, inositol, maltose alcohol, one or more mixed plasticizers in the polyvinyl alcohol; Described flocculation aid is selected from potassium citrate; Described firming agent be selected from carrageenan or/and gellan gum or/and xanthan gum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910185990XA CN101708171B (en) | 2009-12-17 | 2009-12-17 | Enteric plant hollow capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910185990XA CN101708171B (en) | 2009-12-17 | 2009-12-17 | Enteric plant hollow capsule |
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| Publication Number | Publication Date |
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| CN101708171A CN101708171A (en) | 2010-05-19 |
| CN101708171B true CN101708171B (en) | 2011-12-07 |
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|---|---|---|---|
| CN200910185990XA Active CN101708171B (en) | 2009-12-17 | 2009-12-17 | Enteric plant hollow capsule |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103976974B (en) * | 2014-06-11 | 2016-03-09 | 青岛双鲸药业有限公司 | A kind of preparation method of autonomic soft capsules |
| WO2016058160A1 (en) * | 2014-10-16 | 2016-04-21 | 绍兴康可胶囊有限公司 | Enteric plant cellulose hard hollow capsule and preparation method therefor |
| CN104288120B (en) * | 2014-10-16 | 2017-01-18 | 绍兴康可胶囊有限公司 | Enteric-coated plant cellulose hard empty capsules and preparation method thereof |
| CN104922087B (en) * | 2015-05-29 | 2017-08-29 | 湖南尔康制药股份有限公司 | A kind of preparation method of vegetalitas capsulae enterosolubilis |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
| CN109602718A (en) * | 2018-12-24 | 2019-04-12 | 江苏辰星药业股份有限公司 | A kind of enteric plant soft capsule and preparation method thereof |
| CN111388454A (en) * | 2020-04-05 | 2020-07-10 | 刘立新 | Digestive tract regularly disintegrating capsule and its production process |
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|---|---|---|---|---|
| CN1452481A (en) * | 2000-09-01 | 2003-10-29 | 沃纳-兰伯特有限责任公司 | Pectin film compositions |
| CN1606978A (en) * | 2003-10-15 | 2005-04-20 | 浙江省新昌县药联胶丸有限公司 | Hollow capsule of natural plant gum and its preparing process |
| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
-
2009
- 2009-12-17 CN CN200910185990XA patent/CN101708171B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1452481A (en) * | 2000-09-01 | 2003-10-29 | 沃纳-兰伯特有限责任公司 | Pectin film compositions |
| CN1606978A (en) * | 2003-10-15 | 2005-04-20 | 浙江省新昌县药联胶丸有限公司 | Hollow capsule of natural plant gum and its preparing process |
| CN1947709A (en) * | 2005-10-14 | 2007-04-18 | 上海众伟生化有限公司 | Vegetative hard capsule casing material and its prodn. method |
| CN101433526A (en) * | 2007-11-13 | 2009-05-20 | 上海慧源植物胶囊股份有限公司 | Non-gelatine enteric hard capsule shell material and method for producing the same |
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| Publication number | Publication date |
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| CN101708171A (en) | 2010-05-19 |
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Address after: 242605 Xuancheng County, Anhui province Jingde Anhui Mount Huangshan capsule Co., Ltd. Patentee after: Anhui Huangshan Capsule Co.,Ltd. Address before: 242605 Bai Zhen, Jingde County, Anhui Province Patentee before: Anhui Huangshan Capsule Co., Ltd. |