CN101703752B

CN101703752B - Medicinal composition spray or aerosol for treating whitevein and preparation method thereof

Info

Publication number: CN101703752B
Application number: CN200910211259XA
Authority: CN
Inventors: 张樱山; 张国霞; 陈丽娟; 李波
Original assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Current assignee: Gansu Qizheng Tibetan Medicine Co Ltd
Priority date: 2009-11-05
Filing date: 2009-11-05
Publication date: 2012-01-11
Anticipated expiration: 2029-11-05
Also published as: CN101703752A

Abstract

The invention discloses a medicinal composition spray or aerosol for treating whitevein and a preparation method thereof. The spray or aerosol is prepared by taking a formulation of conventional Tibetan medicament white-plus unguent as a basic formulation and modifying the formulation. In the invention, an adopted preparation method of extracting some medicinal materials and making other medicinal materials into superfine powders effectively retains the active ingredients of the medicinal materials, greatly improves the raw medicament component content and improves bioavailability, so that the curative effect of the gel is better. The spray or aerosol of the invention is placed in a sealed container away from oxygen or moisture in air so that the possibility of pollution and metamorphism is reduced and the stability is high; the whitevein spray or aerosol can be directly sprayed onto an action site with uniform medicament distribution and quick response; the spray or aerosol has the characteristics of advanced dosage form, simple and convenient process, quick action and the like; on the basis of ensuring the curative effect, the quality of a product is promoted, and benefited crowds are expanded; and the quality of the product is safer, more stable and controllable due to the adoption of new formulation, new auxiliary materials and new process.

Description

A kind of medicinal composition spray of treating aortic arch syndrome or aerosol and preparation method thereof

Invention field

The present invention relates to a kind of medicinal composition spray or aerosol and preparation method thereof, particularly a kind of medicinal composition spray of treating aortic arch syndrome or aerosol and preparation method thereof.

Technical background

The lung-pulse ointment is that the doctor among the people of Tibetan is carried according to " Tibetan medicine doctor certainly addendum releases difficulty ", the Four-Volume Medical Code two secretaries; In conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, the lung-pulse ointment is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:

Rhizoma Curcumae Longae 150g, Semen Myristicae 50g, Radix Et Rhizoma Nardostachyos 80g, Actinolitum 50g, Radix Glycyrrhizae 70g, artificial Moschus or Moschus 0.7g, Rhizoma Kaempferiae 100g, Fructus cari carvi 130g, Rhizoma Acori Calami 70g, Pericarpium Zanthoxyli 50g, JIANHUA 75g.

Method for making: above ten simply, and except that artificial Moschus or other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and add artificial Moschus or Moschus fine powder facing-up, with butter and Adeps Sus domestica furnishing ointment, promptly get.

Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.

Theoretical according to the Tibetan medicine; Disorders of meridian is divided into the lung-pulse and Hei Mai, and wherein the lung-pulse is the venation that human body at first bears at embryo stage, also is the venation that fetal development obtains nutrition; These venations of birth back play again and absorb diet elite, conveying waste matter; To guarantee the normal circulation of three factors, seven materials,, can cause the generation of various diseases if the function of these venations gets muddled.The main pathogenic factor of aortic arch syndrome has following three aspects: aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; Mechanical damages such as weapons club cause rheumatism; In disorder and go into sering.The Tibetan medicine is the vital energy regualting and blood circulation-promoting collateral dredging to the regulation principle of aortic arch syndrome.Tibetan people is according to the Four-Volume Medical Code, " brilliant pearl book on Chinese herbal medicine " record; In conjunction with long-term practical experience, be the Tibetan medicine the lung-pulse ointment of raw material production with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Moschus, Fructus cari carvi, Pericarpium Zanthoxyli, JIANHUA, receive the trust of extensive patients with significant mass effect; But traditional Tibetan medicine the lung-pulse ointment preparation technology is modulated into ointment after all crude drug fine powders are mixed; Its technology is numerous and diverse, and batch production cycle is long, and production technology is unstable; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, should not bring into play the curative effect of medicine; Product should not be deposited in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.

Summary of the invention

It is medicinal composition spray or the aerosol that basic square tube is crossed the treatment aortic arch syndrome that dosage changing form prepares that the object of the invention is to disclose a kind of prescription with traditional Tibetan medicine the lung-pulse ointment, and the object of the invention also is to disclose the method for preparing of this spray or aerosol.

The present invention seeks to realize through following technical scheme.

The crude drug of spray of the present invention or aerosol is formed and consumption is:

Rhizoma Curcumae Longae 30-40 weight portion, Semen Myristicae 10-15 weight portion, Radix Et Rhizoma Nardostachyos 15-25 weight portion, Actinolitum 10-15 weight portion, Radix Glycyrrhizae 15-20 weight portion, artificial Moschus or Moschus 0.15-0.2 weight portion, Rhizoma Zingiberis 20-28 weight portion, Fructus cari carvi 28-35 weight portion, Rhizoma Acori Calami 15-20 weight portion, Pericarpium Zanthoxyli 10-15 weight portion, JIANHUA 15-20 weight portion.

The crude drug of spray of the present invention or aerosol is formed and consumption is preferably:

Rhizoma Curcumae Longae 36.3 weight portions, Semen Myristicae 12.1 weight portions, Radix Et Rhizoma Nardostachyos 19.4 weight portions, Actinolitum 12.1 weight portions, Radix Glycyrrhizae 17.0 weight portions, artificial Moschus or Moschus 0.17 weight portion, Rhizoma Zingiberis 24.2 weight portions, Fructus cari carvi 31.5 weight portions, Rhizoma Acori Calami 17.0 weight portions, Pericarpium Zanthoxyli 12.1 weight portions, JIANHUA 18.2 weight portions.

The adjuvant of spray of the present invention or aerosol is formed and consumption is:

Propellant: one or more in tetrafluoroethane 0-1200 weight portion, propane 0-200 weight portion, normal butane 0-300 weight portion, monochlorotrifluoromethane 0-100 weight portion, tetrafluorodichloroethane 0-100 weight portion, noble gas 0-1200 weight portion and the dimethyl ether 0-120 weight portion;

Solubilizing agent: Arlacel-20 0-250 weight portion, tween 80 0-250 weight portion, buy in pool-450-350 weight portion, lecithin 0-120 weight portion, paregal O 0-150 weight portion and the peregal A 0-110 weight portion one or more;

Proportion regulator: one or more in Pulvis Talci 0-60 weight portion, sodium sulfate 0-50 weight portion and the magnesium stearate 0-60 weight portion;

Wetting agent: one or more in glycerol 0-220 weight portion, propylene glycol 0-60 weight portion, Polyethylene Glycol 0-120 weight portion, Sorbitol 0-25 weight portion, liquid paraffin 0-10 weight portion, mineral oil 0-10 weight portion, paraffin 0-10 weight portion, squalane 0-25 weight portion, silicone oil aliphatic alcohol 0-20 weight portion and the wax fat 0-20 weight portion;

Excipient: one or more in polyvinylpyrrolidone 0-180 weight portion, hydroxypropyl emthylcellulose 0-160 weight portion, microcrystalline Cellulose 0-150 weight portion, the carboxymethyl cellulose 0-50 weight portion;

Emulsifying agent: one or more in sodium stearate 0-30 weight portion, sodium lauryl sulphate 0-45 weight portion, N-domiphen 0-150 weight portion and the POP polyoxyethylene ether 0-70 weight portion;

Antiseptic: one or more in methyl hydroxybenzoate 0-10 weight portion, sodium benzoate 0-15 weight portion, ethyl hydroxybenzoate 0-10 weight portion and the butoben 0-10 weight portion.

The adjuvant of spray of the present invention or aerosol is formed and consumption is preferably:

Propellant: one or more in tetrafluoroethane 20-1000 weight portion, propane 30-150 weight portion, normal butane 10-250 weight portion, monochlorotrifluoromethane 30-80 weight portion, tetrafluorodichloroethane 30-80 weight portion, noble gas 50-1000 weight portion and the dimethyl ether 30-100 weight portion;

Solubilizing agent: Arlacel-20 20-200 weight portion, tween 80 20-200 weight portion, buy in pool-45 20-300 weight portion, lecithin 20-100 weight portion, paregal O 20-120 weight portion and the peregal A 20-100 weight portion one or more;

Proportion regulator: one or more in Pulvis Talci 10-50 weight portion, sodium sulfate 10-40 weight portion and the magnesium stearate 10-50 weight portion;

Wetting agent: one or more in glycerol 20-200 weight portion, propylene glycol 20-50 weight portion, Polyethylene Glycol 20-100 weight portion, Sorbitol 5-20 weight portion, liquid paraffin 2-8 weight portion, mineral oil 2-8 weight portion, paraffin 2-8 weight portion, squalane 5-20 weight portion, silicone oil aliphatic alcohol 5-15 weight portion and the wax fat 5-15 weight portion;

Excipient: one or more in polyvinylpyrrolidone 20-160 weight portion, hydroxypropyl emthylcellulose 20-150 weight portion, microcrystalline Cellulose 20-120 weight portion, the carboxymethyl cellulose 10-40 weight portion;

Emulsifying agent: one or more in sodium stearate 5-25 weight portion, sodium lauryl sulphate 5-40 weight portion, N-domiphen 20-130 weight portion and the POP polyoxyethylene ether 10-60 weight portion;

Antiseptic: one or more in methyl hydroxybenzoate 2-8 weight portion, sodium benzoate 2-12 weight portion, ethyl hydroxybenzoate 2-8 weight portion and the butoben 2-8 weight portion.

Propellant: one or more in tetrafluoroethane 610 weight portions, propane 115 weight portions, normal butane 155 weight portions, monochlorotrifluoromethane 65 weight portions, tetrafluorodichloroethane 65 weight portions, noble gas 625 weight portions and dimethyl ether 75 weight portions;

Solubilizing agent: Arlacel-20 125 weight portions, tween 80 125 weight portions, buy in pool-45 175 weight portion, lecithin 60 weight portions, paregal O 75 weight portions and peregal A 55 weight portions one or more;

Proportion regulator: one or more in Pulvis Talci 30 weight portions, sodium sulfate 25 weight portions and magnesium stearate 30 weight portions;

Wetting agent: one or more in glycerol 110 weight portions, propylene glycol 30 weight portions, Polyethylene Glycol 60 weight portions, Sorbitol 12 weight portions, liquid paraffin 5 weight portions, mineral oil 5 weight portions, paraffin 5 weight portions, squalane 13 weight portions, silicone oil aliphatic alcohol 10 weight portions and wax fat 10 weight portions;

Excipient: one or more in polyvinylpyrrolidone 90 weight portions, hydroxypropyl emthylcellulose 80 weight portions, microcrystalline Cellulose 75 weight portions and carboxymethyl cellulose 25 weight portions;

Emulsifying agent: one or more in sodium stearate 15 weight portions, sodium lauryl sulphate 23 weight portions, N-domiphen 75 weight portions and POP polyoxyethylene ether 35 weight portions;

Antiseptic: one or more in methyl hydroxybenzoate 5 weight portions, sodium benzoate 8 weight portions, ethyl hydroxybenzoate 5 weight portions and butoben 5 weight portions.

Propellant: one or more in tetrafluoroethane 25 weight portions, propane 195 weight portions, normal butane 15 weight portions, monochlorotrifluoromethane 95 weight portions, tetrafluorodichloroethane 35 weight portions, noble gas 1100 weight portions and dimethyl ether 35 weight portions;

Solubilizing agent: Arlacel-20 245 weight portions, tween 80 10 weight portions, buy in pool-45 345 weight portion, lecithin 10 weight portions, paregal O 145 weight portions and peregal A 5 weight portions one or more;

Proportion regulator: one or more in Pulvis Talci 5 weight portions, sodium sulfate 45 weight portions and magnesium stearate 5 weight portions;

Wetting agent: one or more in glycerol 115 weight portions, propylene glycol 5 weight portions, Polyethylene Glycol 115 weight portions, Sorbitol 5 weight portions, liquid paraffin 9 weight portions, mineral oil 1 weight portion, paraffin 9 weight portions, squalane 5 weight portions, silicone oil aliphatic alcohol 15 weight portions and wax fat 5 weight portions;

Excipient: one or more in polyvinylpyrrolidone 10 weight portions, hydroxypropyl emthylcellulose 155 weight portions, microcrystalline Cellulose 10 weight portions, carboxymethyl cellulose 45 weight portions;

Emulsifying agent: one or more in sodium stearate 25 weight portions, sodium lauryl sulphate 5 weight portions, N-domiphen 145 weight portions and POP polyoxyethylene ether 5 weight portions;

Antiseptic: one or more in methyl hydroxybenzoate 1 weight portion, sodium benzoate 12 weight portions, ethyl hydroxybenzoate 1 weight portion and butoben 9 weight portions.

Propellant: one or more in tetrafluoroethane 1100 weight portions, propane 35 weight portions, normal butane 295 weight portions, monochlorotrifluoromethane 35 weight portions, tetrafluorodichloroethane 95 weight portions, noble gas 55 weight portions and dimethyl ether 115 weight portions;

Solubilizing agent: Arlacel-20 10 weight portions, tween 80 245 weight portions, buy in pool-45 10 weight portion, lecithin 115 weight portions, paregal O 10 weight portions and peregal A 105 weight portions one or more;

Proportion regulator: one or more in Pulvis Talci 55 weight portions, sodium sulfate 5 weight portions and magnesium stearate 55 weight portions;

Wetting agent: one or more in glycerol 10 weight portions, propylene glycol 55 weight portions, Polyethylene Glycol 10 weight portions, Sorbitol 20 weight portions, liquid paraffin 1 weight portion, mineral oil 9 weight portions, paraffin 1 weight portion, squalane 20 weight portions, silicone oil aliphatic alcohol 5 weight portions and wax fat 15 weight portions;

Excipient: one or more in polyvinylpyrrolidone 175 weight portions, hydroxypropyl emthylcellulose 10 weight portions, microcrystalline Cellulose 145 weight portions and carboxymethyl cellulose 5 weight portions;

Emulsifying agent: one or more in sodium stearate 5 weight portions, sodium lauryl sulphate 40 weight portions, N-domiphen 10 weight portions and POP polyoxyethylene ether 65 weight portions;

Antiseptic: one or more in methyl hydroxybenzoate 9 weight portions, sodium benzoate 3 weight portions, ethyl hydroxybenzoate 9 weight portions and butoben 1 weight portion.

Tween 80 50 weight portion glycerol 30 weight portions, polyvinylpyrrolidone 12 weight portions, Pulvis Talci 4 weight portions, sodium stearate 10 weight portions, tetrafluoroethane 150 weight portions;

Or Arlacel-20 200 weight portions, propylene glycol 45 weight portions, carboxymethyl cellulose 12 weight portions, sodium sulfate 1.5 weight portions, propane 180 weight portions;

Or Arlacel-20 185 weight portions, glycerol 200 weight portions, polyvinylpyrrolidone 12 weight portions, sodium stearate 5 weight portions, sodium sulfate 5 weight portions;

Or Sorbitol 25 weight portions, microcrystalline Cellulose 12 weight portions, sodium lauryl sulphate 4 weight portions, sodium sulfate 1.5 weight portions;

Or Tween 80 235 weight portions, silicone oil aliphatic alcohol 10 weight portions, carboxymethyl cellulose 20 weight portions, magnesium stearate 5 weight portions, sodium stearate 10 weight portions;

Or lecithin 110 weight portions, Sorbitol 15 weight portions, hydroxypropyl emthylcellulose 16 weight portions, sodium lauryl sulphate 10 weight portions, sodium sulfate 2 weight portions;

Or buy pool-45 325 weight portion, squalane 8 weight portions, polyvinylpyrrolidone 15 weight portions, magnesium stearate 2.5 weight portions;

Or lecithin 100 weight portions, glycerol 150 weight portions, hydroxypropyl emthylcellulose 12 weight portions, POP polyoxyethylene ether 15 weight portions, Pulvis Talci 4.5 weight portions;

Or peregal A 55 weight portions, liquid paraffin 5 weight portions, mineral oil 5 weight portions, hydroxypropyl emthylcellulose 30 weight portions, Pulvis Talci 20 weight portions, N-domiphen 40 weight portions, monochlorotrifluoromethane 230 weight portions;

Or tween 80 160 weight portions, glycerol 120 weight portions, polyvinylpyrrolidone 150 weight portions, sodium sulfate 30 weight portions, N-domiphen 100 weight portions, tetrafluoroethane 900 weight portions;

Or glycerol 65 weight portions, polyvinylpyrrolidone 18 weight portions, magnesium stearate 25 weight portions, sodium lauryl sulphate 20 weight portions, propane 150 weight portions;

Or buy pool-45 105 weight portion, glycerol 18 weight portions, polyvinylpyrrolidone 18 weight portions, Pulvis Talci 15 weight portions, sodium stearate 15 weight portions, tetrafluoroethane 120 weight portions;

Or paregal O 75 weight portions, polyvinylpyrrolidone 30 weight portions, magnesium stearate 12 weight portions, POP polyoxyethylene ether 50 weight portions, normal butane 250 weight portions;

Or lecithin 105 weight portions, glycerol 200 weight portions, polyvinylpyrrolidone 9 weight portions, sodium sulfate 2.5 weight portions, sodium lauryl sulphate 18 weight portions, dimethyl ether 115 weight portions;

Or peregal A 75 weight portions, wax fat 10 weight portions, hydroxypropyl emthylcellulose 30 weight portions, Pulvis Talci 20 weight portions, N-domiphen 50 weight portions, tetrafluoroethane 200 weight portions;

Or tween 80 200 weight portions, glycerol 150 weight portions, carboxymethyl cellulose 120 weight portions, sodium sulfate 30 weight portions, POP polyoxyethylene ether 60 weight portions, noble gas 800 weight portions, methyl hydroxybenzoate 2.5 weight portions;

Or Arlacel-20 60 weight portions, Sorbitol 10 weight portions, polyvinylpyrrolidone 18 weight portions, magnesium stearate 25 weight portions, sodium stearate 25 weight portions, propane 140 weight portions;

Or Tween 80 100 weight portions, glycerol 18 weight portions, polyvinylpyrrolidone 18 weight portions, Pulvis Talci 15 weight portions, sodium lauryl sulphate 20 weight portions, n-propane 120 weight portions, sodium benzoate 5.0 weight portions;

Or paregal O 120 weight portions, propylene glycol 20 weight portions, polyvinylpyrrolidone 30 weight portions, magnesium stearate 12 weight portions, N-domiphen 60 weight portions, normal butane 170 weight portions;

Or peregal A 100 weight portions, Polyethylene Glycol 110 weight portions, polyvinylpyrrolidone 9 weight portions, sodium lauryl sulphate 18 weight portions, tetrafluoroethane 85 weight portions;

Or tween 80 85 weight portions, glycerol 60 weight portions, polyvinylpyrrolidone 30, Pulvis Talci 30, sodium stearate 15 weight portions, methyl hydroxybenzoate 2.5 weight portions, butoben 2.5 weight portions;

Or Arlacel-20 180 weight portions, glycerol 180 weight portions, polyvinylpyrrolidone 120 weight portions, magnesium stearate 15 weight portions, sodium lauryl sulphate 25 weight portions;

Or lecithin 70 weight portions, glycerol 85 weight portions, polyvinylpyrrolidone 45 weight portions, sodium sulfate 18 weight portions, POP polyoxyethylene ether 35 weight portions, ethyl hydroxybenzoate 2.5 weight portions;

Or paregal O 30 weight portions, peregal A 30 weight portions, glycerol 40 weight portions, polyvinylpyrrolidone 20 weight portions, magnesium stearate 12 weight portions, sodium lauryl sulphate 30 weight portions, sodium benzoate 4.5 weight portions;

Or buy pool-45 80 weight portion, glycerol 100 weight portions, polyvinylpyrrolidone 20 weight portions, sodium sulfate 12 weight portions, POP polyoxyethylene ether 45 weight portions, ethyl hydroxybenzoate 3.5 weight portions;

Or tween 80 245 weight portions, glycerol 200 weight portions, polyvinylpyrrolidone 9 weight portions, Pulvis Talci 7.5 weight portions, sodium stearate 8 weight portions, ethyl hydroxybenzoate 5.0 weight portions;

Or tween 80 85 weight portions, glycerol 90 weight portions, Pulvis Talci 30, N-domiphen 18 weight portions, sodium benzoate 5.5 weight portions;

Or buy pool-45 225 weight portion, glycerol 160 weight portions, microcrystalline Cellulose 100 weight portions, magnesium stearate 25 weight portions, N-domiphen 85 weight portions, sodium benzoate 7.5 weight portions;

Or span 20 75 weight portions, Polyethylene Glycol 90 weight portions, polyvinylpyrrolidone 50 weight portions, magnesium stearate 18 weight portions, sodium lauryl sulphate 40 weight portions, butoben 2.5 weight portions;

Or paregal O 24 weight portions, peregal A 24 weight portions, hydroxypropyl emthylcellulose 40 weight portions, magnesium stearate 12 weight portions, POP polyoxyethylene ether 45 weight portions, sodium benzoate 4.5 weight portions;

Or buy pool-45 95 weight portion, glycerol 90 weight portions, polyvinylpyrrolidone 20 weight portions, sodium sulfate 12 weight portions, sodium lauryl sulphate 25 weight portions, ethyl hydroxybenzoate 3.5 weight portions;

Or lecithin 110 weight portions, glycerol 215 weight portions, carboxymethyl cellulose 12 weight portions, Pulvis Talci 7.5 weight portions, sodium benzoate 3.5 weight portions.

The method for preparing of spray of the present invention or aerosol comprises a kind of in following A, the B method:

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the medicated powder that particle diameter is 0.1-150 μ m;

3. solubilizing agent, wetting agent, excipient and emulsifying agent are used the 40-90% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-85%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

1. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;

2. take by weighing the 10%-100% of above-mentioned mixed material medicine total amount; Boil 1-4 time with 5-20 times of weight decocting; The each decoction 0.5-3 hour, collection, merge extractive liquid, and volatile oil, it is the concentrated solution of 1.0-1.5 that filtration and concentrated extracting solution become relative density; And volatile oil joined in the concentrated solution, concentrated solution a;

Or take by weighing the 10%-100% of above-mentioned mixed material medicine total amount, and with the 30-90% ethanol extraction of 5-20 times of weight 1-4 time, extracted 0.5-24 hour at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.0-1.5;

3. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 0.1-150 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient and emulsifying agent are used the 40-90% dissolve with ethanol; Add the concentrated solution a that 2. step make, the medicated powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-85%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The method for preparing of spray of the present invention or aerosol preferably includes a kind of in following A, the B method method:

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the superfine powder that particle diameter is 0.1-1 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 40% dissolve with ethanol; Add the superfine powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing 10% of above-mentioned mixed material medicine total amount, boil 4 times, decocted 3 hours at every turn with 5 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.25-1.35 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 10% of above-mentioned mixed material medicine total amount, and with 30% ethanol extraction of 5 times of weight 4 times, extracted 3 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.25-1.35;

3. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 0.1-1 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient, emulsifying agent are used 50% dissolve with ethanol; Add the concentrated solution a that 2. step make, the medicated powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The method for preparing of spray of the present invention or aerosol preferably includes a kind of in following A, the B method:

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the superfine powder that particle diameter is 1-10 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 50% dissolve with ethanol; Add the superfine powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-50%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 20% of above-mentioned mixed material medicine total amount, and with 40% ethanol extraction of 15 times of weight 3 times, extracted 1 hour at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.35-1.45;

3. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 1-10 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient, emulsifying agent are used 40% dissolve with ethanol; Add the concentrated solution a that 2. step make, the superfine powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the superfine powder that particle diameter is 10-40 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 60% dissolve with ethanol; Add the superfine powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 50% of above-mentioned mixed material medicine total amount, and with 50% ethanol extraction of 20 times of weight 1 time, extracted 1.5 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 10-40 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient, emulsifying agent are used 70% dissolve with ethanol; Add the concentrated solution a that 2. step make, the superfine powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-50%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the medicated powder that particle diameter is 40-60 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 70% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 60% of above-mentioned mixed material medicine total amount, and with 80% ethanol extraction of 10 times of weight 2 times, extracted 20 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.05-1.15;

3. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 40-60 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient, emulsifying agent are used 60% dissolve with ethanol; Add the concentrated solution a that 2. step make, the medicated powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the medicated powder that particle diameter is 60-90 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 80% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 70-80%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing 90% of above-mentioned mixed material medicine total amount, and with 90% ethanol extraction of 10 times of weight 1 time, extracted 24 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

3. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 60-90 μ m;

4. artificial Moschus or Moschus are ground to form fine powder;

5. solubilizing agent, wetting agent, excipient, emulsifying agent are used 80% dissolve with ethanol; Add the concentrated solution a that 2. step make, the medicated powder that 3. step makes, artificial Moschus or Moschus fine powder and the proportion regulator that 4. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 70-80%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The A method:

1. artificial Moschus or Moschus are ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the medicated powder that particle diameter is 90-150 μ m;

3. solubilizing agent, wetting agent, excipient, emulsifying agent are used 90% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 75-85%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

The B method:

2. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

Or take by weighing above-mentioned mixed material medicine, and 60% ethanol extraction that difference medicament gross weight is 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and being condensed into relative density is the concentrated solution a of 1.05-1.15;

3. artificial Moschus or Moschus are ground to form fine powder;

4. solubilizing agent, wetting agent, excipient, emulsifying agent are used 90% dissolve with ethanol; Add the concentrated solution a that 2. step make, artificial Moschus or Moschus fine powder and the proportion regulator that 3. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 75-85%; Mixing; Fill is sealed after sealing or charge into propellant, promptly gets spray of the present invention or aerosol;

Description of drawings

Fig. 1: medicine of the present invention and the lung-pulse ointment comparison diagram action time

Spray of the present invention or aerosol are compared with prior art the lung-pulse ointment has following characteristics:

1, spray of the present invention or aerosol place in the hermetic container, directly do not contact with airborne oxygen or moisture, have reduced and have polluted and rotten possibility, good stability.

2, the lung-pulse spray of the present invention or aerosol are sprayed directly on to site of action, and drug distribution is even, and is rapid-action.

3, the present invention has the dosage form advanced person, and technology is easy, acts on characteristics such as rapid.On the basis that guarantees curative effect, promoted product quality, enlarged beneficiaries, the employing of novel form, new adjuvant, new technology makes product quality safer, stable, controlled.

Following experimental example and embodiment are used to further specify but are not limited to the present invention.

The analgesia effect experiment of experimental example 1 spray of the present invention and aerosol

1 reagent, animal and instrument

1.1 reagent

The lung-pulse ointment (XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides) of conventional dosage forms;

The lung-pulse ointment 1 (method for preparing: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, JIANHUA pick totally, is ground into the superfine powder that particle diameter is 10 ~ 40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol; 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate adds water to 100 parts, stirs system cream at 75 ~ 85 ℃; Add Moschus when waiting to be cooled to 35 ~ 40 ℃ and stir, process ointment, discharging; Room temperature was placed 3 ~ 8 hours, and the adding antiseptic is an amount of, and packing promptly gets; );

The lung-pulse ointment 2 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, volatile oil is collected in decocte with water 1 time simultaneously, and amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs; );

The lung-pulse ointment 3 (method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs; );

Medicine I of the present invention (embodiment 1 is prepared from the description according to the present invention), medicine II of the present invention (embodiment 7 is prepared from the description according to the present invention), glacial acetic acid etc.

1.2 instrument

The whipping dolorimeter.

1.3 animal

Kunming mouse, body weight 20 ± 2g, 4 monthly ages female Mus.

2 methods and result

2.1 method

Adopt the whipping dolorimeter to measure mouse tail point 2cm place pain threshold before the experiment, screen the animal of whipping between 2 seconds to 10 seconds.Select 70 of qualified mices for use, after the depilation of back barium sulfide, be divided into 7 groups at random, 10 every group, establish blank control group, conventional dosage forms the lung-pulse ointment group, 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, medicine I of the present invention group, medicine II of the present invention group respectively.Smear administration according to dosage back every day in the table 1; Medicine I group of the present invention, medicine II of the present invention group back are smeared aerosol of the present invention and spray medicinal liquid respectively, and blank control group is smeared the substrate that equal-volume I of the present invention does not contain medicinal liquid, administration every day 1 time; Successive administration 3 days; Last administration 1h, 2h, test mouse tail point whipping time (s) behind the 3h.

2.2 result

Adopt SPSS11.5 analytical data result; After variance analysis shows administration 1h; Conventional dosage forms the lung-pulse ointment group, 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, medicine I of the present invention group and medicine II of the present invention group have all obviously prolonged the whipping time of mice; Between blank control group and the conventional dosage forms the lung-pulse ointment group significant difference (P＜0.05) is arranged, each group of blank control group and other all has utmost point significant difference (P＜0.01).No difference of science of statistics between 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of each groups of the lung-pulse ointment.No difference of science of statistics between medicine I group of the present invention and the medicine II of the present invention group; And have utmost point significant difference (P＜0.01) between the blank control group, conventional dosage forms the lung-pulse ointment group, and has significant difference (P＜0.05) between 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of each groups of the lung-pulse ointment.Blank control group all has utmost point significant difference (P＜0.01) with other each group behind the 2h, equal no difference of science of statistics between 3 groups of 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, the lung-pulse ointment.There is not significant difference between medicine I group of the present invention and the medicine II of the present invention group; Have utmost point significant difference (P＜0.01) with blank control group, conventional dosage forms the lung-pulse ointment group, and 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, the lung-pulse ointment respectively has significant difference (P＜0.05) between the group for 3 groups.Respectively organize behind the 3h between the data difference with 1h after.

Data result prompting conventional dosage forms the lung-pulse ointment group, 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of the lung-pulse ointment, medicine I of the present invention group and medicine II of the present invention group all can prolong the whipping time of mice, and analgesic activity is all arranged; The analgesic activity no difference of science of statistics of medicine I group of the present invention and medicine II of the present invention group, effect is close, and analgesic activity all is superior to other each group (P＜0.01) (P＜0.05); 1 group of the lung-pulse ointment, 2 groups of the lung-pulse ointment, 3 groups of three groups of analgesic activity no difference of science of statistics of the lung-pulse ointment, and all be superior to conventional dosage forms the lung-pulse ointment group (P＜0.05).Result such as table 1.

Table 1 aerosol of the present invention, spray are to the influence of whipping time due to the thermostimulation

(compare △ P＜0.05, △ △ P＜0.01 with blank control group; Compare * P＜0.05, * * P＜0.01 with conventional dosage forms the lung-pulse ointment group; Compare ★ P＜0.05, ★ ★ P＜0.01 with medicine I group of the present invention)

The screening test of experimental example 2 various adjuvants

1, the optimization test of excipient

1. the selection of excipient

Take by weighing Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, the artificial Moschus of recipe quantity is ground to form fine powder; 60% ethanol extraction that all the other medical materials difference medicament gross weights are 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and was condensed into the concentrated solution that relative density is 1.05-1.15; Tween 80 25g, glycerol 6g and dissimilar excipient are used 90% dissolve with ethanol, add concentrated solution, artificial Moschus's powder and Pulvis Talci 4g again, stir; Adding ethanol makes the alcohol amount of containing reach 75-85%; Mixing, fill is sealed; Observe the product dissolubility and feeling after using carried out subjective assessment, the result sees table 2.

Table 2 preparations shaping Journal of Sex Research

Can know by table 2, the bonded products dissolubility with use subjective assessment, the present invention selects polyvinylpyrrolidone, hydroxypropyl emthylcellulose, microcrystalline Cellulose, the carboxymethyl cellulose adjuvant as the medicinal liquid mouldability.

2. the selection of amount of excipient

According to the form below 3 design tables make an experiment, and process the spray of different excipient, observe the product dissolubility, carry out subjective assessment to the influence of jet angle and to feeling after using, and the result sees table 4.

The different excipient EXPERIMENTAL DESIGN of table 3 scheme table

The different excipient result of the test of table 4 table

Experimental result shows; The optimum amount of excipient is: the 0.4-0.6 that polyvinylpyrrolidone accounts for crude drug doubly, the 0.4-0.6 that hydroxypropyl emthylcellulose accounts for crude drug doubly, microcrystalline Cellulose account for crude drug 0.4-0.6 doubly, carboxymethyl cellulose account for crude drug 0.1-0.2 doubly.

2, the optimization test of propellant:

1. the selection of propellant

Take by weighing Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, the artificial Moschus of recipe quantity is ground to form fine powder; 60% ethanol extraction that all the other medical materials difference medicament gross weights are 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and was condensed into the concentrated solution that relative density is 1.05-1.15; Tween 80 25g, glycerol 6g, polyvinylpyrrolidone 100g are used 90% dissolve with ethanol, add concentrated solution, artificial Moschus's powder and Pulvis Talci 4g again, stir; Adding ethanol makes and contains alcohol amount and reach 75-85%, mixing, fill; Seal; Charge into different propellant, the intermiscibility of observation and medicine, result of the test is seen table 5.

Table 5 propellant and the experiment of medicine intermiscibility

Can be known by table 5: monochlorotrifluoromethane, tetrafluoroethane, tetrafluorodichloroethane, propane, normal butane, noble gas, dimethyl ether all have certain dissolubility with medicinal liquid; Increase along with its amount; Layering appears in system; The upper strata is the clarification medicinal liquid that has dissolved the part propellant, and lower floor is excessive propellant, so the preferred monochlorotrifluoromethane of the present invention, tetrafluoroethane, tetrafluorodichloroethane, propane, normal butane, noble gas, dimethyl ether are as propellant.

2. the selection of propellant consumption

According to the form below 6 design tables make an experiment, and process the spray of different propellant, under same test conditions, investigate different propellant consumptions to each influence of investigating index, and the result sees table 7.

The different propellant design of table 6 table

The different propellant result of the test of table 7 table

Experimental result shows; The optimum amount of propellant is: the 0.4-1.0 that monochlorotrifluoromethane accounts for crude drug doubly, the 1.0-4.0 that tetrafluoroethane accounts for crude drug doubly, tetrafluorodichloroethane account for crude drug 0.2-0.4 doubly, propane account for crude drug 0.4-1.0 doubly, normal butane account for crude drug 0.4-1.0 doubly, noble gas account for crude drug 1.0-4.0 doubly, dimethyl ether account for crude drug 0.25-0.5 doubly.

3, the optimization test of wetting agent:

1. the selection of wetting agent

Take by weighing Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g, artificial Moschus's grinding is made be uniformly dispersed; 60% ethanol extraction that all the other medical materials difference medicament gross weights are 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and was condensed into the concentrated solution that relative density is 1.05-1.15; Tween 80 25g, polyvinylpyrrolidone 100g and different wetting agent are used 90% dissolve with ethanol, add concentrated solution, artificial Moschus's powder and Pulvis Talci 4g again, stir; Adding ethanol makes and contains alcohol amount and reach 75-85%, mixing, fill; Seal; Charge into tetrafluoroethane, observe medicine moisture retention situation in 3-5 days, the result sees table 8.

The moistening effect of the various wetting agents of table 8 relatively

Annotate: bad: moisture preserving time is short, 1-2 minute;

Good: moisture preserving time is long, 7-9 minute;

Better: moisture preserving time is moderate, 5-7 minute.

Used wetting agent all has tangible moisture-keeping function among the present invention, and wherein the moisture-keeping function of glycerol, Polyethylene Glycol, Sorbitol, propylene glycol, silicone oil aliphatic alcohol is best.

2. the selection according to the form below 9 design tables of wetting agent consumption make an experiment, and process the plaster of different wetting agents, and room temperature is placed, and observe medicine moisture retention situation in 3-5 days, and the result sees table 10.

Table 9 wetting agent is investigated the design table

The different wetting agent moistening effect of table 10 table

Experimental result shows; The optimum amount of wetting agent is: the 0.4-0.8 that glycerol accounts for crude drug doubly, the 0.1-0.2 that propylene glycol accounts for crude drug doubly, Polyethylene Glycol account for crude drug 0.2-0.5 doubly, Sorbitol account for crude drug 0.05-0.1 doubly, the silicone oil aliphatic alcohol account for crude drug 0.05-0.1 doubly.

Experimental example 3 pharmaceutical compositions of the present invention and the lung-pulse ointment stability contrast test data

(1) test specimen:

Tradition the lung-pulse ointment: XiZang QiZheng Tibetan pharmaceuticals Co., Ltd provides;

The lung-pulse ointment 1: method for preparing: 1. Moschus is ground to form fine powder for 0.08 part; 2. with 20 parts in Rhizoma Curcumae Longae, 5 parts of Semen Myristicaes, 10 parts of Radix Et Rhizoma Nardostachyos, 5 parts of Actinolitum, 8 parts in Radix Glycyrrhizae,, 10 parts of 12 parts of Rhizoma Kaempferiaes, 15 parts of Fructus cari carvis, 8 parts of Rhizoma Acori Calamis, 7 parts in Pericarpium Zanthoxyli, JIANHUA pick totally, is ground into the superfine powder that particle diameter is 10 ~ 40 μ m; , 3. get step superfine powder 2. and place container for 20 parts, add 8 parts liquid paraffin therein, 8 parts glycerol; 9 parts of Tween-80s, 0.2 part of methyl hydroxybenzoate adds water to 100 parts, stirs system cream at 75 ~ 85 ℃; Add Moschus when waiting to be cooled to 35 ~ 40 ℃ and stir, process ointment, discharging; Room temperature was placed 3 ~ 8 hours, and the adding antiseptic is an amount of, and packing promptly gets;

The lung-pulse ointment 2: method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, volatile oil is collected in decocte with water 1 time simultaneously, and amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs;

The lung-pulse ointment 3: method for preparing: 1. Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, JIANHUA 9g are made only, pulverize, mix homogeneously, subsequent use; 2. take by weighing 50% of mixed powder gross weight, the alcohol reflux with 50% 1 time extracted 1.5 hours, and alcohol adding amount is 20 times of medical material gross weight, and 50 ℃ of temperature are collected extracting solution; Filter, be condensed into proportion and be 1.0 concentrated solution, subsequent use; 3. will remain medicated powder (50%) be ground into the medicated powder of 0.01 ~ 200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ subsequent use; 4. get the 100g lanoline; Gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure; Treat that temperature reduces to 30 ℃, add and promptly process ointment after the artificial Moschus stirs;

Medicine 1 of the present invention: embodiment 1 preparation in the description according to the present invention;

Medicine 2 of the present invention: embodiment 7 preparations in the description according to the present invention.

(2) experimental condition:

Time: from continuous three months of beginning in zero month, investigated once in every month, be later on June, December, respectively investigated once in 24 months.

Temperature: room temperature

Relative humidity: relative humidity is 35%～75%

(3) testing result: see table 11.

The stable comparative test result of table 11 medicine of the present invention and the lung-pulse ointment

Experimental example 4 medicines of the present invention and the lung-pulse ointment contrast test action time data

Test specimen:

Medicine 2 of the present invention: embodiment 7 preparations in the description according to the present invention

The present invention adopts the transdermal test method that exsomatizes, and gets white mice, and etherization carefully cuts off back wool with shears; Put to death, peel off skin of back, remove subcutaneous fat and mucous tissue, after cleaning with physiological saline solution; Place the joint portion of the vertical diffusion cell of Franz, dermis of skin accurately takes by weighing above-mentioned the lung-pulse ointment and medicine of the present invention towards receiving liquid; Evenly coat skin surface, reception tank adds 30ml receiver media (constant temperature (32 ± 1) ℃, mixing speed 100r/min).Respectively at 0,1,3,6,9; 12,24h sampling 2ml (replenishing receiver media 2ml simultaneously) puts in the 25ml measuring bottle, is diluted to scale with methanol solution, as need testing solution; Operate with method with blank sample, make blank solution, measure trap in the 430nm wavelength, experimental result is seen Fig. 1.

Following embodiment all can realize the effect of above-mentioned experimental example

The specific embodiment

Embodiment 1: aerosol of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

Adjuvant is formed:

Tween 80 50g, glycerol 30g, polyvinylpyrrolidone 12g, Pulvis Talci 4g, sodium stearate 10g, tetrafluoroethane 150g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. tween 80, glycerol, polyvinylpyrrolidone, sodium stearate are used 40% dissolve with ethanol, add the superfine powder that 2. step make, artificial Moschus or Moschus fine powder and the Pulvis Talci that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol of the present invention.

Embodiment 2: aerosol of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

Adjuvant is formed:

Arlacel-20 200g, propylene glycol 45g, carboxymethyl cellulose 12g, sodium sulfate 1.5g, propane 180g;

Method for making:

1. Moschus is ground to form fine powder;

3. Arlacel-20, propylene glycol, carboxymethyl cellulose are used 50% dissolve with ethanol, add the superfine powder that 2. step make, Moschus fine powder and the sodium sulfate that 1. step makes again, stir; Adding ethanol makes and contains alcohol amount and reach 40-50%, mixing, fill; Seal, charge into propane, promptly get aerosol of the present invention.

Embodiment 3: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Arlacel-20 185g, glycerol 200g, polyvinylpyrrolidone 12g, sodium stearate 5g, sodium sulfate 5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. span 20, glycerol, polyvinylpyrrolidone, sodium stearate are used 40% dissolve with ethanol; Add the superfine powder that 2. step make, artificial Moschus or Moschus fine powder and the sodium sulfate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 4: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Sorbitol 25g, microcrystalline Cellulose 12g, sodium lauryl sulphate 4g, sodium sulfate 1.5g;

Method for making:

1. Moschus is ground to form fine powder;

3. peregal A, microcrystalline Cellulose, sodium lauryl sulphate are used 50% dissolve with ethanol, add the superfine powder that 2. step make, Moschus fine powder and the sodium sulfate that 1. step makes again, stir; Adding ethanol makes and contains alcohol amount and reach 40-50%, mixing, fill; Seal, promptly get spray of the present invention.

Embodiment 5: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 235g, silicone oil aliphatic alcohol 10g, carboxymethyl cellulose 20g, magnesium stearate 5g, sodium stearate 10g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. Tween 80, silicone oil aliphatic alcohol, carboxymethyl cellulose, sodium stearate are used 60% dissolve with ethanol; Add the superfine powder that 2. step make, artificial Moschus's fine powder and the magnesium stearate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 6: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Lecithin 110g, Sorbitol 20g, hydroxypropyl emthylcellulose 16g, sodium lauryl sulphate 10g, sodium sulfate 2g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. lecithin, Sorbitol, hydroxypropyl emthylcellulose, sodium lauryl sulphate are used 70% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus's fine powder and the sodium sulfate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 7: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Buy pool-45325g, squalane 8g, polyvinylpyrrolidone 15g, magnesium stearate 2.5g;

Method for making:

1. Moschus is ground to form fine powder;

3. will buy pool-45, squalane, polyvinylpyrrolidone, use 80% dissolve with ethanol, add the medicated powder that 2. step make, Moschus fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes and contains alcohol amount and reach 70-80%, mixing, fill; Seal, promptly get spray of the present invention.

Embodiment 8: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Lecithin 100g, glycerol 150g, hydroxypropyl emthylcellulose 12g, POP polyoxyethylene ether 15g, Pulvis Talci 4.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. lecithin, glycerol, hydroxypropyl emthylcellulose, POP polyoxyethylene ether are used 90% dissolve with ethanol; Add the medicated powder that 2. step make, artificial Moschus's fine powder and the Pulvis Talci that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 75-85%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 9: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Peregal A 55g, liquid paraffin 5g, mineral oil 5g, hydroxypropyl emthylcellulose 30g, Pulvis Talci 20g, N-domiphen 40g, monochlorotrifluoromethane 230g;

Method for making:

1. Moschus is ground to form fine powder;

2. with Rhizoma Curcumae Longae, Semen Myristicae, dry and soft, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA remove impurity, clean system is mixed;

3. take by weighing 10% of above-mentioned mixed material medicine total amount, with 30% ethanol extraction of 5 times of weight 4 times, extracted 3 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.25-1.35;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 0.1-1 μ m;

5. peregal A, liquid paraffin, mineral oil, hydroxypropyl emthylcellulose, N-domiphen are used 50% dissolve with ethanol, add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, Moschus fine powder and the Pulvis Talci that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 60-70%; Mixing, fill is sealed; Charge into monochlorotrifluoromethane, promptly get aerosol of the present invention.

Embodiment 10: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 160g, glycerol 120g, polyvinylpyrrolidone 150g, sodium sulfate 30g, N-domiphen 100g, tetrafluoroethane 900g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 20% of above-mentioned mixed material medicine total amount,, extracted 1 hour at every turn, collect extracting solution, filter, be condensed into the concentrated solution that relative density is 1.35-1.45 with 40% ethanol extraction of 15 times of weight 3 times;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 1-10 μ m;

5. tween 80, glycerol, polyvinylpyrrolidone, N-domiphen are used 40% dissolve with ethanol, add the concentrated solution that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder and the sodium sulfate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol of the present invention.

Embodiment 11: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Glycerol 65g, polyvinylpyrrolidone 18g, magnesium stearate 25g, sodium lauryl sulphate 20g, propane 150g;

Method for making:

1. Moschus is ground to form fine powder;

3. take by weighing 50% of above-mentioned mixed material medicine total amount,, extracted 1.5 hours at every turn, collect extracting solution, filter, be condensed into the concentrated solution that relative density is 1.15-1.25 with 50% ethanol extraction of 20 times of weight 1 time;

4. will remain hybrid medicine and be ground into the superfine powder that particle diameter is 10-40 μ m;

5. glycerol, polyvinylpyrrolidone, sodium lauryl sulphate are used 70% dissolve with ethanol, add the concentrated solution that 3. step make, the superfine powder that 4. step makes, Moschus fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 40-50%; Mixing, fill is sealed; Charge into propane, promptly get aerosol of the present invention.

Embodiment 12: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Buy pool-45 105g, glycerol 18g, polyvinylpyrrolidone 18g, Pulvis Talci 15g, sodium stearate 15g, tetrafluoroethane 120g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 60% of above-mentioned mixed material medicine total amount,, extracted 20 hours at every turn, collect extracting solution, filter, be condensed into the concentrated solution that relative density is 1.05-1.15 with 80% ethanol extraction of 10 times of weight 2 times;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 40-60 μ m;

5. will buy pool-45, glycerol, polyvinylpyrrolidone, sodium stearate and use 60% dissolve with ethanol, add the concentrated solution that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder and the Pulvis Talci that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol of the present invention.

Embodiment 13: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Paregal O 75g, polyvinylpyrrolidone 30g, magnesium stearate 12g, POP polyoxyethylene ether 50g, normal butane 250g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 90% of above-mentioned mixed material medicine total amount,, extracted 24 hours at every turn, collect extracting solution, filter, be condensed into the concentrated solution that relative density is 1.15-1.25 with 90% ethanol extraction of 10 times of weight 1 time;

4. will remain hybrid medicine and be ground into the medicated powder that particle diameter is 60-90 μ m;

5. paregal O, vinylpyrrolidone, POP polyoxyethylene ether are used 80% dissolve with ethanol, add the concentrated solution that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 70-80%; Mixing, fill is sealed; Charge into normal butane, promptly get aerosol of the present invention.

Embodiment 14: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Lecithin 105g, glycerol 200g, polyvinylpyrrolidone 9g, sodium sulfate 2.5g, sodium lauryl sulphate 18g, dimethyl ether 115g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing above-mentioned mixed material medicine, 60% ethanol extraction that difference medicament gross weight is 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and was condensed into the concentrated solution that relative density is 1.05-1.15;

4. lecithin, glycerol, polyvinylpyrrolidone, sodium lauryl sulphate are used 90% dissolve with ethanol, add the concentrated solution that 3. step make, artificial Moschus's fine powder and the sodium sulfate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 75-85%; Mixing, fill is sealed; Charge into dimethyl ether, promptly get aerosol of the present invention.

Embodiment 15: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Peregal A 75g, wax fat 10g, hydroxypropyl emthylcellulose 30g, Pulvis Talci 20g, N-domiphen 50g, tetrafluoroethane 200g;

Method for making:

1. Moschus is ground to form fine powder;

3. take by weighing 10% of above-mentioned mixed material medicine total amount; Boil 4 times with 5 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 3 hours; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.25-1.35, and with volatile oil join in the concentrated solution concentrated solution a;

5. peregal A, wax fat, hydroxypropyl emthylcellulose, N-domiphen are used 50% dissolve with ethanol, add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, Moschus fine powder and the Pulvis Talci that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 60-70%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol of the present invention.

Embodiment 16: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 200g, glycerol 150g, carboxymethyl cellulose 120g, sodium sulfate 30g, POP polyoxyethylene ether 60g, noble gas 800g, methyl hydroxybenzoate 2.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 20% of above-mentioned mixed material medicine total amount, boil 3 times, decocted 1 hour at every turn with 15 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.35-1.45 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

5. tween 80, glycerol, carboxymethyl cellulose, POP polyoxyethylene ether are used 40% dissolve with ethanol, add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder, sodium sulfate, the methyl hydroxybenzoate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into noble gas, promptly get aerosol of the present invention.

Embodiment 17: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Arlacel-20 60g, Sorbitol 10g, polyvinylpyrrolidone 18g, magnesium stearate 25g, sodium stearate 25g, propane 140g;

Method for making:

1. Moschus is ground to form fine powder;

3. take by weighing 50% of above-mentioned mixed material medicine total amount, boil 1 time, decocted 1.5 hours at every turn with 20 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

5. Arlacel-20, Sorbitol, polyvinylpyrrolidone, sodium stearate are used 70% dissolve with ethanol, add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, Moschus fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 40-50%; Mixing, fill is sealed; Charge into propane, promptly get aerosol of the present invention.

Embodiment 18: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 100g, glycerol 18g, polyvinylpyrrolidone 18g, Pulvis Talci 15g, sodium lauryl sulphate 20g, normal butane 120g, sodium benzoate 5.0g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 60% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

5. Tween 80, glycerol, polyvinylpyrrolidone, sodium lauryl sulphate are used 60% dissolve with ethanol, add the concentrated solution a that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder, Pulvis Talci, the sodium benzoate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into normal butane, promptly get aerosol of the present invention.

Embodiment 19: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Paregal O 120g, propylene glycol 20g, polyvinylpyrrolidone 30g, magnesium stearate 12g, N-domiphen 60g, normal butane 170g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 90% of above-mentioned mixed material medicine total amount, boil 2 times, decocted 2.5 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.15-1.25 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

5. paregal O, propylene glycol, polyvinylpyrrolidone, N-domiphen are used 80% dissolve with ethanol, add the concentrated solution a that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 70-80%; Mixing, fill is sealed; Charge into normal butane, promptly get aerosol of the present invention.

Embodiment 20: aerosol of the present invention

Crude drug is formed:

Adjuvant is formed:

Peregal A 100g, Polyethylene Glycol 110g, polyvinylpyrrolidone 9g, sodium lauryl sulphate 18g, tetrafluoroethane 750g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing above-mentioned mixed material medicine, boil 3 times, decocted 2 hours at every turn with 10 times of weight decoctings; Collection, merge extractive liquid, and volatile oil; It is the concentrated solution of 1.05-1.15 that filtration and concentrated extracting solution become relative density, and volatile oil is joined in the concentrated solution, gets concentrated solution a;

4. peregal A, Polyethylene Glycol, polyvinylpyrrolidone, sodium lauryl sulphate are used 90% dissolve with ethanol, add the concentrated solution a that 3. step make, artificial Moschus's fine powder that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 75-85%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol of the present invention.

Embodiment 21: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 85g, glycerol 60g, polyvinylpyrrolidone 30, Pulvis Talci 30, sodium stearate 15g, methyl hydroxybenzoate 2.5g, butoben 2.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

5. tween 80, glycerol, polyvinylpyrrolidone, sodium stearate are used 40% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder, Pulvis Talci, methyl hydroxybenzoate, the butoben that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-50%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 22: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Arlacel-20 180g, glycerol 180g, polyvinylpyrrolidone 120g, magnesium stearate 15g, sodium lauryl sulphate 25g;

Method for making:

1. Moschus is ground to form fine powder;

3. take by weighing 20% of above-mentioned mixed material medicine total amount; Boil 3 times with 15 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 1 hour; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.35-1.45, and with volatile oil join in the concentrated solution concentrated solution a;

5. Arlacel-20, glycerol, polyvinylpyrrolidone, sodium lauryl sulphate are used 50% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, Moschus fine powder, the magnesium stearate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 23: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Lecithin 70g, glycerol 85g, polyvinylpyrrolidone 45g, sodium sulfate 18g, POP polyoxyethylene ether 35g, ethyl hydroxybenzoate 2.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 50% of above-mentioned mixed material medicine total amount; Boil 1 time with 20 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 1.5 hours; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.15-1.25, and with volatile oil join in the concentrated solution concentrated solution a;

5. lecithin, glycerol, polyvinylpyrrolidone, POP polyoxyethylene ether are used 60% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder, sodium sulfate, the ethyl hydroxybenzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 24: spray of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

Adjuvant is formed:

Paregal O 30g, peregal A 30g, glycerol 40g, polyvinylpyrrolidone 20g, magnesium stearate 12g, sodium lauryl sulphate 30g, sodium benzoate 4.5g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 60% of above-mentioned mixed material medicine total amount; Boil 2 times with 10 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 2.5 hours; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.05-1.15, and with volatile oil join in the concentrated solution concentrated solution a;

5. paregal O, peregal A, glycerol, polyvinylpyrrolidone, sodium lauryl sulphate are used 70% dissolve with ethanol; Add the concentrated solution a that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder, magnesium stearate, the sodium benzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.Embodiment 25: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Buy pool-45 80g, glycerol 100g, polyvinylpyrrolidone 20g, sodium sulfate 12g, POP polyoxyethylene ether 45g, ethyl hydroxybenzoate 3.5g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 90% of above-mentioned mixed material medicine total amount; Boil 2 times with 10 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 2.5 hours; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.15-1.25, and with volatile oil join in the concentrated solution concentrated solution a;

5. will buy pool-45, glycerol, polyvinylpyrrolidone, POP polyoxyethylene ether and use 80% dissolve with ethanol; Add the concentrated solution that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder, sodium sulfate, the ethyl hydroxybenzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 26: spray of the present invention

Crude drug is formed:

Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos, 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

Adjuvant is formed:

Tween 80 245g, glycerol 200g, polyvinylpyrrolidone 9g, Pulvis Talci 7.5g, sodium stearate 8g, ethyl hydroxybenzoate 5.0g;

1. Moschus is ground to form fine powder;

3. take by weighing above-mentioned mixed material medicine; Boil 3 times with 10 times of weight decoctings, decocted collection, merge extractive liquid, and volatile oil at every turn 2 hours; Filter and concentrated extracting solution to become relative density be the concentrated solution of 1.05-1.15, and with volatile oil join in the concentrated solution concentrated solution a;

5. tween 80, glycerol, polyvinylpyrrolidone, sodium stearate are used 90% dissolve with ethanol; Add the concentrated solution a that 3. step make, Moschus fine powder, Pulvis Talci, the ethyl hydroxybenzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 75-85%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 27: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Tween 80 85g, glycerol 90g, Pulvis Talci 30, N-domiphen 18g, sodium benzoate 5.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

5. tween 80, glycerol, N-domiphen are used 40% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder, Pulvis Talci, the sodium benzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 40-50%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 28: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Buy pool-45 225g, glycerol 160g, microcrystalline Cellulose 100g, magnesium stearate 25g, N-domiphen 85g, sodium benzoate 7.5g;

Method for making:

1. Moschus is ground to form fine powder;

3. take by weighing 20% of above-mentioned mixed material medicine total amount, with 40% ethanol extraction of 15 times of weight 3 times, extracted 1 hour at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.35-1.45;

5. will buy pool-45, glycerol, microcrystalline Cellulose, N-domiphen and use 50% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, Moschus fine powder, magnesium stearate, the sodium benzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 29: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Span 20 75g, Polyethylene Glycol 90g, polyvinylpyrrolidone 50g, magnesium stearate 18g, sodium lauryl sulphate 40g, butoben 2.5g;

Method for making:

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 50% of above-mentioned mixed material medicine total amount, with 50% ethanol extraction of 20 times of weight 1 time, extracted 1.5 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

5. span 20, Polyethylene Glycol, polyvinylpyrrolidone, sodium lauryl sulphate are used 60% dissolve with ethanol; Add the concentrated solution a that 3. step make, the superfine powder that 4. step makes, artificial Moschus's fine powder, magnesium stearate, the ethyl hydroxybenzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 30: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Paregal O 24g, peregal A 24g, hydroxypropyl emthylcellulose 40g, magnesium stearate 12g, POP polyoxyethylene ether 45g, sodium benzoate 4.5g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 60% of above-mentioned mixed material medicine total amount, with 80% ethanol extraction of 10 times of weight 2 times, extracted 20 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.05-1.15;

5. paregal O, peregal A, hydroxypropyl emthylcellulose, POP polyoxyethylene ether are used 70% dissolve with ethanol; Add the concentrated solution a that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder, magnesium stearate, the sodium benzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 50-60%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 31: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Buy pool-45 95g, glycerol 90g, polyvinylpyrrolidone 20g, sodium sulfate 12g, sodium lauryl sulphate 25g, ethyl hydroxybenzoate 3.5g;

1. the artificial Moschus is ground to form fine powder;

3. take by weighing 90% of above-mentioned mixed material medicine total amount, with 90% ethanol extraction of 10 times of weight 1 time, extracted 24 hours at every turn, collect extracting solution, filter, being condensed into relative density is the concentrated solution a of 1.15-1.25;

5. will buy pool-45, glycerol, polyvinylpyrrolidone, sodium lauryl sulphate and use 80% dissolve with ethanol; Add the concentrated solution that 3. step make, the medicated powder that 4. step makes, artificial Moschus's fine powder, sodium sulfate, the ethyl hydroxybenzoate that 1. step makes again, stir, add ethanol and make and contain the alcohol amount and reach 60-70%; Mixing; Fill is sealed, and promptly gets spray of the present invention.

Embodiment 32: spray of the present invention

Crude drug is formed:

Adjuvant is formed:

Lecithin 110g, glycerol 215g, carboxymethyl cellulose 12g, Pulvis Talci 7.5g, sodium benzoate 3.5g;

1. Moschus is ground to form fine powder;

3. take by weighing above-mentioned mixed material medicine, 60% ethanol extraction that difference medicament gross weight is 10,8,6 times 3 times extracted respectively 90,60,30 minutes at every turn, collected extracting solution, filtered, and being condensed into relative density is the concentrated solution a of 1.05-1.15;

5. lecithin, glycerol, carboxymethyl cellulose are used 90% dissolve with ethanol, add the concentrated solution a that 3. step make, Moschus fine powder, Pulvis Talci, the sodium benzoate that 1. step makes again, stir; Adding ethanol makes and contains alcohol amount and reach 75-85%, mixing, fill; Seal, promptly get spray of the present invention.

Claims

1. aerosol of treating aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, artificial Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

The adjuvant that it is characterized in that this aerosol consists of:

This aerosol is processed by following method:

1. the artificial Moschus is ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the superfine powder that particle diameter is 0.1-1 μ m;

3. tween 80, glycerol, polyvinylpyrrolidone, sodium stearate are used 40% dissolve with ethanol, add the superfine powder that 2. step make, artificial Moschus's fine powder and the Pulvis Talci that 1. step makes again, stir; Adding ethanol makes the alcohol amount of containing reach 50-60%; Mixing, fill is sealed; Charge into tetrafluoroethane, promptly get aerosol.

2. spray of treating aortic arch syndrome, its crude drug consists of: Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, JIANHUA 18.2g;

The adjuvant that it is characterized in that this spray consists of:

Myrij-45 325g, squalane 8g, polyvinylpyrrolidone 15g, magnesium stearate 2.5g;

This spray preparing process is:

1. Moschus is ground to form fine powder;

2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli and JIANHUA are picked totally, be ground into the medicated powder that particle diameter is 60-90 μ m;

3. with Myrij-45, squalane, polyvinylpyrrolidone, use 80% dissolve with ethanol, add the medicated powder that 2. step make, Moschus fine powder and the magnesium stearate that 1. step makes again, stir; Adding ethanol makes and contains alcohol amount and reach 70-80%, mixing, fill; Seal, promptly get spray.

3. be used for the application of the medicine of relaxing muscles and tendons and activating QI and blood in the collateral in preparation like the arbitrary described spray of claim 1-2 or aerosol.

4. has the application in the medicine of analgesic activity like the arbitrary described spray of claim 1-2 or aerosol in preparation.