CN101698043A - Compound aloe capsule and preparation method thereof - Google Patents
Compound aloe capsule and preparation method thereof Download PDFInfo
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- CN101698043A CN101698043A CN 200910180596 CN200910180596A CN101698043A CN 101698043 A CN101698043 A CN 101698043A CN 200910180596 CN200910180596 CN 200910180596 CN 200910180596 A CN200910180596 A CN 200910180596A CN 101698043 A CN101698043 A CN 101698043A
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Abstract
The invention discloses a compound aloe capsule and a preparation method thereof. The compound aloe capsule is a hard capsule traditional Chinese medicine preparation which is prepared by the method as follows: specifically processing, extracting and refining the raw materials including aloe, natural indigo, cinnabar and amber respectively, and then mixing the raw materials, granulating, filling and the like. The compound aloe capsule provided by the invention has the functions of clearing away heat from liver, relaxing bowel and calming the heart and tranquilizing the mind, and has obvious curative effects on exuberance of heart and liver fire, constipation, abdominal distension and pain, restlessness and sleeplessness, etc. The compound aloe capsule has confirmed curative effects, stable and controllable quality and is easy to carry and convenient to take.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, specifically, relate to a kind of preparation method of compound Aloe capsule.
Background technology
Constipation is a kind of more common disease, and is in the majority with the gerontal patient especially, but along with expanding economy, the quickening of rhythm of life, the patient of constipation is more and more, and is to young and middle-aged development trend.The serious disease though constipation is nothing often causes bigger misery for the patient, conscience fire Sheng, constipation, abdominal distention stomachache, irritated insomnia etc. occur, not only influences quality of life, and also brings certain difficulty for operate as normal.Prolonged constipation can cause a skin ulcer, proctoptosis, anal fissure, rectal cancer, and can bring out cerebrovascular disease, even some old man dies suddenly when the defecation because of constipation.
Compound Aloe capsule is a kind of Chinese medicine preparation for the treatment of constipation, derives from the ball of changing one's clothes of bright Miao Xiyong.The ball side of changing one's clothes goes out " wake up earlier vegetarian medical science extensively take down notes " volume one, and name is seen " name hospital opinion at all times " volume four.Prescription is made up of Aloe, Cinnabaris.Wherein, Aloe porphyrize, seven money, Cinnabaris grind like flying, five money.Drip good wine a little and ball.Every clothes one Qian Erfen, good wine gulps down.Court dress is logical dusk, and dusk, clothes were towards logical.Backfit was wonderful when the palpus sky was fine." name hospital opinion at all times ": Ke Yun uncle day: stomach is a foundation of acquired constitution, and is sick not as good as solid, too also sick.So have too again the excess of YANG, the deficiency of YIN not here.Two sun close bright and excess syndrome of the stomach and intestines, and Zhong Jing system three is held the gas purgation; Extreme misery is not handed over and body fluid is died, and former worthies make the ball of changing one's clothes again to moisten it.Ancients go into the lavatory and must change one's clothes, so ball founds name for this reason.The justice of medication is assigned and yields result heavily to weigh down.The Cinnabaris red complexion belongs to fire, and body weight resembles gold, and sweet in the mouth is returned soil, and class water cold in nature is red ancestral's hydrargyrum mother, can fail bank to fill out from, unboiled water with the fire that helps, be kidney man psychological treatment also; Be equipped with Aloe, black leads to kidney, and bitterness is gone into the heart, and the matter of moistening can be changeed and moistened dryness of the stomach, and appetizing is closed under the performance in Great Cold, and this yin aspect of yin truly be the man host of kidney.Close and think ball, coordinating water and fire reason is arranged, water and soil close and justice, both mutual reinforcements between must be imitated very grandly, it is very prompt to yield result, very unimaginably queer person.As seen, the change one's clothes curative effect of pill for curing constipation is very definite.
Cinnabaris is as medicinal history at the existing more than one thousand years of China.Because Cinnabaris has curative effect preferably, the successive dynasties, the medicine scholar created many name sides, used the prescription of Cinnabaris constantly to increase, and was widely used.Often use clinically contain the Cinnabaris prescription, patent medicine has tens kinds, wherein has famous and precious Chinese patent medicines, particularly Cinnabaris such as cow-bezoar bolus for resurrection, Bezoar Sedative Pills, ZIXUEDAN, most valuable treasure DANJI Cinnabar Sedative Pill particularly general with using in the Chinese patent medicine children's.Lv Shi shows that to the Cinnabaris prescription statistical result that contains that Song dynasty " peaceful Huimin mixture office side ", Ming Dynasty's " Standards of Diagnosis and Treatment " (five) " pediatrics " and four editions Pharmacopoeias of the People's Republic of China record generally about 10%, Gao Zheke reaches 30% to the Cinnabaris medicine frequency." there are 47 kinds to contain Cinnabaris in 398 kinds of Chinese medicine prescriptions that Chinese pharmacopoeia is recorded, account for 12% of sum at 1995 editions.By above statistical result as can be seen in the successive dynasties prescription medicine frequency of Cinnabaris be higher, simultaneously illustrate that also successive dynasties Chinese medicine scholar is sure to the effect of Cinnabaris.
" Chinese pharmacopoeia is clear and definite Cinnabaris is sulfide-based mineral cinnabar family cinnabar, Containing Sulfur hydrargyrum must not be less than 96.0%, and processed product Cinnabaris powder Containing Sulfur hydrargyrum must not be less than 98.0%.According to scientific research, what human body absorbed easily is free mercury, and cinnabar is not absorbed by the body.Yet along with country is more and more stricter to the control of mining, the resource of Cinnabaris also can more and more be restricted, and along with the continuous enhancing of people's health care consciousness, can more and more become estranged mercurous preparation.Therefore, the compound Aloe capsule that we have invented, and clinical effectiveness is identical, Cinnabaris content reduces, the safety of the ball of changing one's clothes is higher relatively.
Compound Aloe capsule prescription is made up of Aloe, Indigo Naturalis, Cinnabaris, succinum, has that liver heat removing is purged heat, a function of loosening bowel to relieve constipation, mind tranquilizing and the heart calming, is used for conscience fire Sheng, constipation, abdominal distention stomachache, the irritated determined curative effect of having a sleepless night.
Aloe in the side, hardship, cold.Removing heat from the liver.Get the merit of its bitter cold relieving constipation by purgation, be used for purging heat to relax the bowels, be monarch drug.Indigo Naturalis, salty-cold, heat-clearing and toxic substances removing, purging liver-fire is ministerial drug.The monarch and his subjects' phase 5 brings out the best in each other, and has strengthened liver heat removing and has let out fire, functions of loosening bowel relieving constipation.Cinnabaris, sweet, be slightly cold.Mind tranquilizing and the heart calming.The existing heat effect that clears away heart-fire has the removing heat from the liver effect again, collaborative Indigo Naturalis, Aloe liver heat removing, and liver-heat gets clearly, and heart-fire descends, coordination between the heart and kidney, all diseases of irritated insomnia are eliminated; Succinum, sweet, flat.It is relieving convulsion to calm the nerves, with Cinnabaris be adjuvant altogether.Full side plays altogether that liver heat removing is purged heat, the merit of loosening bowel to relieve constipation, mind tranquilizing and the heart calming.
Summary of the invention
The object of the present invention is to provide a kind of compound Aloe capsule and preparation method thereof with bowel relaxing functions.Compound Aloe capsule provided by the invention is made by following parts by weight of Chinese traditional medicine raw material:
1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part.
Raw material of Chinese medicine in the above-mentioned prescription also can be processed with other modes except that the preparation that directly feeds intake, and makes pharmaceutically active substance, subsequently, is raw material with this active substance, adds acceptable carrier in the pharmaceutical preparation when needing, and makes the capsule formulation on the pharmaceutics.Described active substance can obtain by the method that is selected from following mode, as: by pulverize, squeeze, grind, sieve, water flies, percolation, water are carried, alcohol extraction, ester are carried, ether is carried, big empty resin is carried etc., and method obtains, these active substances can be that dry extract also can be a fluid extract, make different concentration according to the different needs decision of preparation.
A kind of compound Aloe capsule provided by the invention and preparation method thereof can comprise the steps: Aloe, Indigo Naturalis, Cinnabaris and succinum, handle by the preferred process of preparing Chinese medicine, processing method respectively, after taking by weighing by weight ratio, through operations such as pulverizing, medicated powder mixing, capsule charge, polishing, packings, promptly.After medicated powder mixes, also can granulate and refill capsule after (can add the pharmaceutically adjuvant of approval during granulation) as any one or a few the mixture in stearic acid, silicon dioxide, magnesium stearate, Pulvis Talci, the micropowder silica gel etc.
The process of preparing Chinese medicine, processing method, step and the technological parameter thereof of raw material can be as follows in a kind of compound Aloe capsule provided by the invention and preparation method thereof:
Aloe: choose and pick up removal impurity, be broken into fritter, it is interior in 80-120 ℃ of dry 10-40 hour to put drying baker, and it is standby to be ground into 60-200 order fine powder; Perhaps be ground into 10-100 order powder, with ethanol (concentration 40%-95%) reflux, extract,, the extract drying is ground into 60-200 order fine powder again, and is standby.
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ steam sterilization 1-3 hour, cool, take out and put the inherent 80-120 ℃ of drying of drying baker, be ground into 60-200 order fine powder, standby; Perhaps the sterilization back adopts elutriation to fly into fine powder, and drying is crossed the 100-200 mesh sieve, and fine powder is standby.
Cinnabaris: adopt elutriation to fly into fine powder, drying is crossed the 120-200 mesh sieve, and fine powder is standby.
Succinum: remove impurity, the water purification branch is drenched in the water flushing, is put in the drying baker in 80-120 ℃ of dry 4-20 hour, is ground into 65-200 order fine powder, and is standby.
Medicated powder mixed processes in a kind of compound Aloe capsule provided by the invention and preparation method thereof, can adopt the medicated powder of four flavors after the raw material pulverizing to be mixed together, also can adopt four Chinese medicine powder combination back to mix, also can adopt multiple modes such as equivalent incremental method, facing-up method to mix.
Granulation process in a kind of compound Aloe capsule provided by the invention and preparation method thereof can adopt dry granulation.
Granulation process in a kind of compound Aloe capsule provided by the invention and preparation method thereof can adopt wet granulation, and adhesive can adopt one or more the mixture in syrup, starch slurry, ethanol, water, cellulose family of variable concentrations etc.
Granulation process in a kind of compound Aloe capsule provided by the invention and preparation method thereof, can adopt one-step palletizing (or boiling granulating), adhesive can adopt one or more the mixture in syrup, starch slurry, ethanol, water, cellulose family of variable concentrations etc.
Mixed processes in a kind of compound Aloe capsule provided by the invention and preparation method thereof, granulation process can add the lubricant of approving on the pharmaceutics, as silicon dioxide, magnesium stearate, Pulvis Talci etc.
For effect of the present invention is described, we have prepared sample segment and have carried out some clinical trials, and situations such as diagnostic criteria, efficacy determination and result are as follows:
One, diagnostic criteria
1. meet doctor trained in Western medicine functional constipation diagnostic criteria (with reference to Rome III standard):
1.1 must satisfy following 2 or many:
A. defecation effort (having 1 time in per at least 4 defecations).
B. defecation is block or firmly just (has 1 time in per at least 4 defecations).
C. there is defecation to feel (having 1 time in per at least 4 defecations) not to the utmost.
D. have anal orifice and rectal intestine to block and (or) block sense (having 1 time in per at least 4 defecations).
E. need manipulation (at the bottom of pointing auxiliary defecation, basin, supporting defecation) to promote defecation (having 1 time in per at least 4 defecations).
F. defecation is less than week＜3 time.
1.2 almost do not have just soft when not using laxative;
1.3 there are not enough evidence diagnosis irritable bowel syndromes.
Symptom occurs at least 6 months before the diagnosis, and symptom met above standard in nearly 3 months.
2. constipation conscience fire is contained card syndrome differential diagnosis standard: (with reference to Chinese Internal Medicine five editions)
Primary symptom: defecation frequency reduces, constipation with dry stool, and difficult defecation, defecation time prolongs.
Inferior disease: abdominal distention, bitter taste xerostomia, yellowish or reddish urine, agitation, insomnia.)
Tongue arteries and veins: red tongue, yellow fur, rolling pulse or stringy and rolling pulse.
Possess primary symptom more than two or two, inferior disease needs two (in one and back three in satisfying preceding at least two simultaneously one) or more than two, and is promptly diagnosable in conjunction with the tongue arteries and veins.
3. symptom quantitative criteria:
3.1 primary symptom quantitative criteria:
Annotate: a. formulates with reference to digestology branch of Chinese Medical Association.
B.B:Bristol feces character typing.
3.2 inferior disease quantitative criteria:
Annotate: a. formulates with reference to new Chinese medicine clinical guidance principle (version in 2002).
Two, include standard in:
Age 〉=18 year old and≤65 years old patient, the men and women does not limit.
2. meet doctor trained in Western medicine functional constipation, traditional Chinese medical science constipation conscience fire Sheng card syndrome differential diagnosis standard person.
3. pass by not take the Chinese and Western medicine relevant in 2 weeks with primary disease.
4. informed consent is tried voluntarily.
Three, exclusion standard:
1. the constipation patient with sympotoms occurs, turn out to be the narrow causer of intestinal due to rectum, the colon organic disease (as tumor, clone disease, polyp of colon, tuberculosis of intestine etc.) through diformazan with go to the hospital barium coloclysis or enteroscopy in 6 months.
2. the patient who has the warning symptom such as weak of having blood in stool, become thin.
3. irritable bowel syndrome.
4. gestation or women breast-feeding their children.
5. to the known composition allergy sufferers of this medicine.
6. be associated with serious primary disease person such as cardiovascular, liver, kidney or hemopoietic system, the psychotic.
7. researcher is thought and should not be participated in this experimenter.
Four, the method for administration and the course of treatment:
Method of administration: 2/time, 2 times/day, oral.
Specification: every is equivalent to crude drug in whole 0.5g
The course of treatment: 7 days.
Five, curative effect determinate standard:
1. main curative effect index: medication is after 7 days, all defecation frequencies.
2. individual event primary symptom criterion (all defecation frequencies)
Clinic control: after finishing the course of treatment, transference cure.
Produce effects: after finishing the course of treatment, the symptom classification reduces 2 grades.
Effectively: after finishing the course of treatment, the symptom classification reduces 1 grade.
Invalid: as not reach above-mentioned standard person.
3. constipation curative effect determinate standard
With 4 primary symptom curative effects as MAIN OUTCOME MEASURES.Criterion is as follows:
Clinical recovery: therapeutic index n 〉=95%;
Produce effects: 95%＞therapeutic index n 〉=70%;
Effectively: 70%＞therapeutic index n 〉=30%;
Invalid: therapeutic index n＜30%.
Annotate: the curative effect of disease formula of index: therapeutic index (n)=[primary symptom integration before (primary symptom integration before treating-treatment back primary symptom integration) ÷ treatment] * 100%.
4. tcm syndrome curative effect determinate standard
Be almost recovered: symptom integral reduces percentage rate 〉=95%.
Produce effects: 95%＞symptom integral reduces percentage rate 〉=70%.
Effectively: 70%＞symptom integral reduces percentage rate 〉=30%.
Invalid: symptom integral reduces percentage rate＜30%.
Annotate: symptom integral reduces percentage rate=[integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%.
5. relieving constipation onset time criterion
Onset time: take medicine for the first time to discharging the time of stool for the first time.
Six, result of the test (constipation curative effect)
This test has 110 routine patients and participates in, wherein male 52 people, women 58 people, and clinical recovery, produce effects, effective, invalid patient's ratio are respectively 87.27%, 6.36%, 1.82%, 4.55%.
The invention will be further described below in conjunction with embodiment, simultaneously, practicality of the present invention is described.
The specific embodiment
1 one kinds of compound Aloe capsules of embodiment and preparation method thereof
Take by weighing 1 part of Aloe, 1.5 parts of Indigo Naturaliss, 0.39 part in Cinnabaris, 1.5 parts of succinums by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker in 80-100 ℃ of drying, be ground into 10 order medicated powder, use 95% alcohol reflux, the extract drying is ground into 60 order medicated powder again, and is standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ of steam sterilizations 1 hour are put in the drying baker in 80-100 ℃ of drying again, cross 60 mesh sieves, and medicated powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, dry below 40 ℃, cross 120 mesh sieves, fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 80-100 ℃ of drying, is ground into 60 order medicated powder, and is standby.
Above-mentioned Aloe powder, Indigo Naturalis powder, Cinnabaris powder and Succinum powder were mixed 1.5 hours, add 0.5% magnesium stearate again and mix, capsule charge, promptly.
2 one kinds of compound Aloe capsules of embodiment and preparation method thereof
Take by weighing 1 part of Aloe, 1.1 parts of Indigo Naturaliss, 0.1 part in Cinnabaris, 1.1 parts of succinums by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker, be ground into 200 order medicated powder in 100-120 ℃ of drying, standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ of steam sterilizations 2 hours are put in the drying baker in 100-120 ℃ of drying again, fly into fine powder with elutriation, and drying is crossed 200 mesh sieves, and fine powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, dry below 40 ℃, cross 200 mesh sieves, fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 100-120 ℃ of drying, is ground into 200 order medicated powder, and is standby.
Above-mentioned Aloe powder, Indigo Naturalis powder, Cinnabaris powder and Succinum powder were mixed 1 hour, use 78% alcohol granulation, dry below 40 ℃, add 0.1% magnesium stearate again and mix, capsule charge, promptly.
3 one kinds of compound Aloe capsules of embodiment and preparation method thereof
Take by weighing 1 part of Aloe, 1.2 parts of Indigo Naturaliss, 0.2 part in Cinnabaris, 1.3 parts of succinums by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker, be ground into 100 order medicated powder in 90-110 ℃ of drying, standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ of steam sterilizations 1.5 hours are put in the drying baker in 90-110 ℃ of drying again, cross 100 mesh sieves, and fine powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, dry below 40 ℃, cross 150 mesh sieves, fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 90-110 ℃ of drying, is ground into 100 order medicated powder, and is standby.
Above-mentioned Cinnabaris powder and Succinum powder were mixed 30 minutes, add Aloe powder, the mixing of Indigo Naturalis powder 60 minutes again, do the binding agent boiling granulating with 88% ethanol, capsule charge, promptly.
4 one kinds of compound Aloe capsules of embodiment and preparation method thereof
Take by weighing 1 part of Aloe, 1.2 parts of Indigo Naturaliss, 0.25 part in Cinnabaris, 1.2 parts of succinums by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker, be ground into 100 order medicated powder, use 40% alcohol reflux in 110-120 ℃ of drying, extracting liquid filtering, concentrated, drying is ground into 80 order medicated powder, and is standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ of steam sterilizations 2 hours are put in the drying baker in 110-120 ℃ of drying again, cross 80 mesh sieves, and fine powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, dry below 40 ℃, cross 120 mesh sieves, fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 90-110 ℃ of drying, is ground into 80 order medicated powder, and is standby.
Above-mentioned Aloe powder, Indigo Naturalis powder and Succinum powder were mixed 60 minutes, adopt facing-up method mixing with the Cinnabaris powder again, capsule charge, promptly.
5 one kinds of compound Aloe capsules of embodiment and preparation method thereof
Take by weighing 1 part of Aloe, 1.1 parts of Indigo Naturaliss, 0.15 part in Cinnabaris, 1.4 parts of succinums by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker, be ground into 100 order medicated powder in 100-110 ℃ of drying, standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ of steam sterilizations 1 hour are put in the drying baker in 100-110 ℃ of drying again, cross 80 mesh sieves, and fine powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, dry below 40 ℃, cross 150 mesh sieves, fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 90-110 ℃ of drying, is ground into 100 order medicated powder, and is standby.
Above-mentioned Aloe powder, Indigo Naturalis powder were mixed 30 minutes, and Cinnabaris powder, Succinum powder mixed 30 minutes, and the two remix is 30 minutes then, adds 0.3% silicon dioxide, capsule charge, promptly.
Claims (8)
1. a compound Aloe capsule is characterized in that, is made by following parts by weight of Chinese traditional medicine raw material:
1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part.
2. compound Aloe capsule and preparation method thereof is characterized in that:
Take by weighing 1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker in 80-120 ℃ of drying, be ground into 10-100 order medicated powder, use the 40-95% alcohol reflux, the extract drying is ground into 60-200 order medicated powder again, and is standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, put again in steam sterilization 1-2 hour in the drying baker in 80-120 ℃ of drying for 120 ℃, be ground into 60-200 order medicated powder, standby;
Cinnabaris: adopt elutriation to fly into fine powder, drying is crossed the 150-200 mesh sieve, and fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 80-120 ℃ of drying, is ground into 60-200 order medicated powder, and is standby.
3. compound Aloe capsule and preparation method thereof is characterized in that:
Take by weighing 1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker in 80-120 ℃ of drying, be ground into 10-100 order medicated powder, use the 40-95% alcohol reflux, the extract drying is ground into 60-200 order medicated powder again, and is standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ steam sterilization 1-2 hour, fly into fine powder with elutriation, drying is crossed the 100-200 mesh sieve, fine powder is standby;
Cinnabaris: adopt elutriation to fly into fine powder, drying is crossed the 150-200 mesh sieve, and fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 80-120 ℃ of drying, is ground into 60-200 order medicated powder, and is standby.
4. compound Aloe capsule and preparation method thereof is characterized in that:
Take by weighing 1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker, be ground into 60-200 order medicated powder in 80-120 ℃ of drying, standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ steam sterilization 1-2 hour, put again in the drying baker in 80-120 ℃ of drying, be ground into 60-200 order medicated powder, standby;
Cinnabaris: adopt elutriation to fly into fine powder, drying is crossed the 120-200 mesh sieve, and fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 80-120 ℃ of drying, is ground into 60-200 order medicated powder, and is standby.
5. compound Aloe capsule and preparation method thereof is characterized in that:
Take by weighing 1 part of Aloe, Indigo Naturalis 1.1-1.5 part, Cinnabaris 0.1-0.39 part, succinum 1.1-1.5 part by weight ratio,
Aloe: choose and pick up removal impurity, be broken into fritter, put in the drying baker in 80-120 ℃ of drying, be ground into 10-100 order medicated powder, use the 40-95% alcohol reflux, the extract drying is ground into 60-200 order medicated powder again, and is standby;
Indigo Naturalis: put in the autoclave sterilizer in 0.12Mpa pressure, 120 ℃ steam sterilization 1-2 hour, put again in the drying baker in 80-120 ℃ of drying, be ground into 60-200 order medicated powder, standby;
Cinnabaris: adopt elutriation to fly into fine powder, drying is crossed the 120-200 mesh sieve, and fine powder is standby;
Succinum: remove impurity, the water purification branch is drenched in the water flushing, puts in the drying baker in 80-120 ℃ of drying, is ground into 60-200 order medicated powder, and is standby.
6. according to arbitrary described compound Aloe capsule of claim 2-5 and preparation method thereof, it is characterized in that the production technology method for making comprises medicated powder mixing, capsule charge, polishing, packing, medicated powder can add the adjuvant of pharmacy circle approval when mixing.
7. according to arbitrary described compound Aloe capsule of claim 2-5 and preparation method thereof, it is characterized in that the production technology method for making comprises medicated powder mixing, granulation, capsule charge, polishing, packing, can add the adjuvant of pharmacy circle approval when medicated powder mixing or granulation.
8. the granulation in the production technology method for making of the described compound Aloe capsule of claim 7 can be adopted dry granulation, wet granulation or boiling granulating.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306858A (en) * | 2014-09-26 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Anthelmintic bactericide for human body and preparation method thereof |
| CN114177303A (en) * | 2021-12-23 | 2022-03-15 | 河北万邦复临药业有限公司 | Bowel relaxing composition and preparation method thereof |
-
2009
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306858A (en) * | 2014-09-26 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Anthelmintic bactericide for human body and preparation method thereof |
| CN114177303A (en) * | 2021-12-23 | 2022-03-15 | 河北万邦复临药业有限公司 | Bowel relaxing composition and preparation method thereof |
| CN114177303B (en) * | 2021-12-23 | 2024-01-30 | 河北万邦复临药业有限公司 | Composition for relaxing bowel and preparation method thereof |
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Open date: 20100428 |