CN101676291B - 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 - Google Patents
一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 Download PDFInfo
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- CN101676291B CN101676291B CN200810200073XA CN200810200073A CN101676291B CN 101676291 B CN101676291 B CN 101676291B CN 200810200073X A CN200810200073X A CN 200810200073XA CN 200810200073 A CN200810200073 A CN 200810200073A CN 101676291 B CN101676291 B CN 101676291B
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Description
组别 | N (只) | 剂量 (mg/kg) | 定量溶血OD值 | 特异抗体生成细胞抑制% |
正常对照组 | 6 | — | 0.3036 | — |
模型对照组 | 6 | — | 0.3887 | — |
CsA | 6 | 10 | 0.3472 | 48.82 |
Rapamycin | 6 | 1.5 | 0.3012 | 100 |
Y31 | 6 | 1.5 | 0.3095 | 93.03 |
Claims (9)
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CN200810200073XA CN101676291B (zh) | 2008-09-18 | 2008-09-18 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
BRPI0913726A BRPI0913726A2 (pt) | 2008-09-18 | 2009-09-17 | rapalogs, composições farmacêuticas, métodos de preparo e uso dos mesmos |
MX2011002783A MX2011002783A (es) | 2008-09-18 | 2009-09-17 | Rapalogos, composiciones farmaceuticas, metodos de preparacion y usos de los mismos. |
EP09813972A EP2351757A4 (en) | 2008-09-18 | 2009-09-17 | RAPAMYCIN-CARBON ACID ANALOGUE, PHARMACEUTICAL COMPOSITIONS, PREPARATIONS AND THEIR USE |
PCT/CN2009/001042 WO2010031251A1 (zh) | 2008-09-18 | 2009-09-17 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
US13/119,700 US8455510B2 (en) | 2008-09-18 | 2009-09-17 | Rapamycin carbonic ester analogues, pharmaceutical compositions, preparations and uses thereof |
CA2737355A CA2737355C (en) | 2008-09-18 | 2009-09-17 | Rapalogs, pharmaceutical compositions, preparation methods and uses thereof |
JP2011527184A JP5394493B2 (ja) | 2008-09-18 | 2009-09-17 | ラパマイシン炭酸エステル類似体、薬剤組成物、製造方法及び用途 |
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CN (1) | CN101676291B (zh) |
BR (1) | BRPI0913726A2 (zh) |
CA (1) | CA2737355C (zh) |
MX (1) | MX2011002783A (zh) |
WO (1) | WO2010031251A1 (zh) |
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MX2013011412A (es) * | 2011-04-01 | 2014-04-30 | Sandoz Ag | Acilacion regioselectiva de rapamicina en la posicion c-42. |
KR20220002713A (ko) | 2011-04-29 | 2022-01-06 | 셀렉타 바이오사이언시즈, 인크. | 치료적 단백질에 대해 면역 반응을 감소시키는 관용원성 합성 나노운반체 |
CA2836914C (en) * | 2011-06-06 | 2016-01-26 | Arbor Therapeutics, LLC | Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents |
JP2016517889A (ja) * | 2013-05-03 | 2016-06-20 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | 薬力学的効果の低減または向上のための寛容原性合成ナノ担体および治療用高分子 |
CN106715456B (zh) | 2014-08-12 | 2023-08-29 | 莫纳什大学 | 定向淋巴的前药 |
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JP6912377B2 (ja) | 2014-11-05 | 2021-08-04 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | ラパログを含む合成ナノキャリアの生産における低hlb界面活性剤の使用に関連した方法および組成物 |
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JP2019533718A (ja) | 2016-09-27 | 2019-11-21 | セレクタ バイオサイエンシーズ インコーポレーテッドSelecta Biosciences,Inc. | がんの処置における使用のための組換え免疫毒素 |
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- 2008-09-18 CN CN200810200073XA patent/CN101676291B/zh active Active
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2009
- 2009-09-17 MX MX2011002783A patent/MX2011002783A/es active IP Right Grant
- 2009-09-17 CA CA2737355A patent/CA2737355C/en not_active Expired - Fee Related
- 2009-09-17 EP EP09813972A patent/EP2351757A4/en not_active Withdrawn
- 2009-09-17 WO PCT/CN2009/001042 patent/WO2010031251A1/zh active Application Filing
- 2009-09-17 JP JP2011527184A patent/JP5394493B2/ja not_active Expired - Fee Related
- 2009-09-17 BR BRPI0913726A patent/BRPI0913726A2/pt not_active IP Right Cessation
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BRPI0913726A2 (pt) | 2015-10-13 |
US8455510B2 (en) | 2013-06-04 |
CA2737355C (en) | 2015-01-13 |
CA2737355A1 (en) | 2010-03-25 |
EP2351757A4 (en) | 2012-05-02 |
US20110166172A1 (en) | 2011-07-07 |
JP5394493B2 (ja) | 2014-01-22 |
WO2010031251A1 (zh) | 2010-03-25 |
CN101676291A (zh) | 2010-03-24 |
JP2012502930A (ja) | 2012-02-02 |
EP2351757A1 (en) | 2011-08-03 |
MX2011002783A (es) | 2011-09-01 |
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