CN101647958B - Application of conic gymnadenia rhizome in restraining synthesis of skin melanin - Google Patents
Application of conic gymnadenia rhizome in restraining synthesis of skin melanin Download PDFInfo
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- CN101647958B CN101647958B CN200910192273XA CN200910192273A CN101647958B CN 101647958 B CN101647958 B CN 101647958B CN 200910192273X A CN200910192273X A CN 200910192273XA CN 200910192273 A CN200910192273 A CN 200910192273A CN 101647958 B CN101647958 B CN 101647958B
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Abstract
本发明公开了手参在抑制皮肤黑色素合成上的应用。手参对酪氨酸酶具有有效的抑制作用，可以抑制黑色素的生成，达到美白祛斑的效果。The invention discloses the application of hand ginseng in inhibiting skin melanin synthesis. Ginseng has an effective inhibitory effect on tyrosinase, which can inhibit the production of melanin and achieve the effect of whitening and freckle removal.
Description
Technical field
The invention belongs to the field of Chinese medicines and cosmetics technical field, be specifically related to Rhizoma Gymnadeniae and suppressing the application that dermal melanin synthesizes.
Background technology
Along with the progressively improvement of living standard, people also improve constantly the pursuit of U.S., and whitening and speckle dispelling is the target that the women pursued that great majority are liked to be beautiful.The colour of skin depends on melanic generation to a great extent, and melanin is the high-molecular biologic pigment, and the melanic initiation material of Skin Cell " production " is a tyrosine.Tryrosinase in the melanocyte blast cell, the tyrosine generation series reaction with in the blood generates the material of a kind of crying " DOPA ", and then changes into melanin.Therefore,, can suppress melanic synthetic effectively, thereby reach the purpose of whitening and speckle dispelling by the activity of restraint of tyrosinase.
And at present, comparatively effective whitening and speckle dispelling composition, generally acknowledged having is mercurous, the preparation of hydroquinone, beauty treatment circle even they are used as unique effective whitening cosmetics.But, the strong toxicity of this type of preparation, potential safety hazard height.Contain forbidden amphetamine and cross and take effect in ten thousand times hydrargyrum and one week of chemical compound speckle dispelling thereof, toxicity is gathered and is caused the face cell necrosis of countless consumers, stays the blue patch that can not cure; The amount of limiting the use of of hydroquinone is 0.02%, and the hydroquinone that surpasses the amount of limiting the use of hundreds of times just has positive effect, but if life-time service can be repent forever staying abnormal white piece on the face.Therefore, how to obtain the problem that safe and effective whitening and speckle dispelling material is a puzzlement beauty and make-up industry always.
At present domestic the most widely-used and to recognize safe whitening and speckle dispelling material altogether be arbutin, vitamin C and kojic acid.These materials are safe, but simultaneously, also have the shortcoming of DeGrain.Arbutin chemical name: hydroquinone-β-D-glycopyranoside, it can slowly release the activity that hydroquinone stops the enzyme-tryrosinase of melanin generation, demonstrate the melanic effect that suppresses, its arbutin can be to the melanocyte toxigenicity as hydroquinone, the whitening and speckle dispelling raw material that belongs to safety, but the effect of arbutin is too slow, it slowly decomposes the active function that discharges part hydroquinone restraint of tyrosinase and almost is not aware of, all do not have significantly sensation even if life-time service contains the whitening and speckle dispelling product of arbutin, so that people have lost confidence gradually to the whitening and speckle dispelling product that adds arbutin; Vitamin C can be treated posteriority pigmentations such as chloasma hepaticum or Lille melanosis, vitamin C and derivant thereof also are considered to safe whitening and speckle dispelling material, but it is difficult for by skin absorbs, aqueous solution is oxidation deterioration very easily, preserve very difficult, though and successors develop sodium L-ascorbate-2-phosphate, Magnesium L-Asacorbic Acid 2-O-Phosphate etc. and have solved ascorbic stability problem but these derivant poorly water-solubles, be difficult for adding, the usefulness of whitening and speckle dispelling obviously descends; The material that the metabolism of the multiple aspergillus mushroom of kojic acid produces, non-stimulated to skin, can not cause the white macula sequela, human body skin melanin is generated has stronger inhibitory action simultaneously.Kojic acid generates human body skin melanin stronger inhibitory action, usually and composite skin whitening and the sunscreen product of being used as of other whitening and speckle dispelling material, but seldom see independent use kojic acid and the report of remarkable speckle dispelling curative effect is arranged, general whitening and speckle dispelling prescription is also relatively more rare.
Chinese medicine is from natural plant amedica, have different activities compositions such as many active ingredient alkaloids, saponin, flavonoid, organic acid, and different Chinese medicines have different efficacies, what have has a clearing heat, releasing toxin, removing swelling effect, what have has a function of promoting blood circulation to disperse blood clots, having of having moisten whiten, YIN nourishing dampness effect etc.Chinese medicine beauty treatment safe, along with improving constantly of people's living standard, very big change has also taken place in the beauty treatment idea, and traditional Chinese medicine beauty treatment more and more is subjected to people's green grass or young crops and hides.The long at present beauty treatment and eliminating spot Chinese medicine that uses mostly is white Chinese medicine, as the Rhizoma Atractylodis Macrocephalae, Semen Ginkgo, Radix Ampelopsis etc.It has been generally acknowledged that white Chinese medicine all has the effect of white skin, therefore can carry out the beauty treatment medicine of whitening and speckle dispelling by the external approach.But in fact, the Chinese herbal medicine resource of China is very extensive, is containing a large amount of precious resources in the pools of traditional Chinese medicine and is treating in excavation, comprises the Chinese medicine of Pear Power spot-removal function.Therefore, break away from the constraint of " white Chinese medicine ", excavate how more effective whitening and speckle dispelling medicine, to the development based on inheritance Chinese medical culture, meeting the need of market all has great importance at this huge treasure-house of Chinese herbal medicine.
Rhizoma Gymnadeniae is the tuber of the orchid family Rhizoma Gymnadeniae platymiscium Rhizoma Gymnadeniae Gymnadenia conopsea R.Brown, and its chemical constituent comprises dihydro stilbene class, luxuriant and rich with fragrance class, glycoside, the plain class of phenylpropyl alcohol, isoprenoid, derivative of fatty acid etc.There are some researches prove that the pharmacologically active of Rhizoma Gymnadeniae comprises antioxidation, antiallergic, promotion progenitor cell proliferation, suppresses hepatitis B virus surface antigen etc.At present, usually Rhizoma Gymnadeniae is used to tonify Qi of the kidney, the spermatogenesis lung moistening is not seen that any to be used to suppress melanin about Rhizoma Gymnadeniae or Rhizoma Gymnadeniae extract by the external approach synthetic, thereby is reached the report of whitening effect.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, provide Rhizoma Gymnadeniae in the application that suppresses aspect the synthetic and white skin of skin Caring of dermal melanin.
The present invention is achieved through the following technical solutions above-mentioned purpose:
The present invention finds that through a large amount of experiments Rhizoma Gymnadeniae has the good restraining effect to tryrosinase, can suppress the synthetic of dermal melanin.
The Rhizoma Gymnadeniae extracts active ingredients is come out, can be used to prepare the whitening and speckle dispelling product, as paste, white shape, emulsion form or facial film.
The Rhizoma Gymnadeniae extraction of effective components is: Rhizoma Gymnadeniae is soaked, be heated to boiling and keep constant temperature, leach medicinal liquid; Medicinal residues add water and are heated to boiling once more, and slow fire decocts, and leaches medicinal liquid, merge twice medicinal liquid after, be condensed into the Rhizoma Gymnadeniae concentrated solution.
Compared with prior art, the present invention has following beneficial effect:
The present invention finds that through a large amount of experiments Rhizoma Gymnadeniae has the good restraining effect to tryrosinase, can suppress the synthetic of dermal melanin.Adopt the product whitening and speckle dispelling effect of Rhizoma Gymnadeniae effective ingredient preparation remarkable, have a extensive future.
The specific embodiment
Below further specify technical scheme of the present invention by specific embodiment.
Embodiment 1
After Rhizoma Gymnadeniae 40g pulverizes, add deionized water 200g and soak 24h, be heated to boiling then and kept constant temperature 1 hour, leach medicinal liquid; Medicinal residues add the 100g deionized water in addition, and reheat decocts 30 minutes to the slow fire that seethes with excitement, the elimination medicinal residues, with filter for twice medicinal liquid merge, be condensed into 100g Rhizoma Gymnadeniae concentrated solution.
Activity experiment:
The object of observation: age 20-45 year middle-aged women.Choosing is facial middle aged women 100 examples of pigments such as in various degree chloasma, butterfly spot, senile plaque.
Observational technique: behind the cleaning skin, coat above-mentioned emulsion before sleep every night.Using 28 days continuously is a course of treatment.
Criterion of therapeutical effect: 1. recovery from illness: chloasma disappears substantially; 2. produce effects: chloasma disappears more than 50%; 3. effective: chloasma disappears more than 10% or the patch color changes light; 4. invalid: no change before and after the treatment.
Therapeutic effect such as table 1:
Table 1
| Grouping | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| Facial film by the preparation of embodiment 1 Rhizoma Gymnadeniae concentrated solution | 100 | 80 | 8 | 6 | 6 | 94％ |
Claims (3)
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| CN200910192273XA CN101647958B (en) | 2009-09-11 | 2009-09-11 | Application of conic gymnadenia rhizome in restraining synthesis of skin melanin |
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| CN200910192273XA CN101647958B (en) | 2009-09-11 | 2009-09-11 | Application of conic gymnadenia rhizome in restraining synthesis of skin melanin |
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| CN101647958A CN101647958A (en) | 2010-02-17 |
| CN101647958B true CN101647958B (en) | 2011-06-08 |
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| CN200910192273XA Expired - Fee Related CN101647958B (en) | 2009-09-11 | 2009-09-11 | Application of conic gymnadenia rhizome in restraining synthesis of skin melanin |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103535731A (en) * | 2013-11-01 | 2014-01-29 | 王颖 | Method for extracting essence material of conic gymnadenia rhizome |
| CN104288054A (en) * | 2014-10-25 | 2015-01-21 | 广州丹奇日用化工厂有限公司 | Chinese herbal medicine composition for removing freckles as well as preparation method and application of Chinese herbal medicine composition |
| CN109939057A (en) * | 2019-04-08 | 2019-06-28 | 上海浩泰生物科技有限公司 | Rhizoma gymnadeniae extracting method and related gymnadenia conopsea extraction |
| CN114569534A (en) * | 2022-03-15 | 2022-06-03 | 百草正源(广东)中医药发展有限公司 | Whitening and freckle removing cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456297A (en) * | 2003-04-10 | 2003-11-19 | 毛友昌 | Tablet for regulating menstruation and removing spot, preparing method thereof |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456297A (en) * | 2003-04-10 | 2003-11-19 | 毛友昌 | Tablet for regulating menstruation and removing spot, preparing method thereof |
| CN101342318A (en) * | 2008-09-03 | 2009-01-14 | 青海省格拉丹东药业有限公司 | Medicament composition for nourishing blood, regulating menstruation and removing speckle, and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 覃筱燕 等.《藏药旺拉的化学成分及药理活性的研究进展》.《中央民族大学学报（自然科学版）》.2007,第16卷(第3期),229-232. |
| 覃筱燕等.《藏药旺拉的化学成分及药理活性的研究进展》.《中央民族大学学报(自然科学版)》.2007,第16卷(第3期),229-232. * |
| 黄胜阳 等.《藏药旺拉的氨基酸成分分析》.《中国民族民间医药杂志》.2002,(第57期),229-232. |
| 黄胜阳等.《藏药旺拉的氨基酸成分分析》.《中国民族民间医药杂志》.2002,(第57期),229-232. * |
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| CN101647958A (en) | 2010-02-17 |
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