CN101612220B - External-application cream for treating osteoarthritis and preparation method thereof - Google Patents

Abstract

The invention relates to a medicament for treating osteoarthritis and a preparation method thereof, and discloses an external cream for treating osteoarthritis and a preparation method thereof. The external cream mainly adopts the following components according to weight parts per 1000 grams of raw materials: safflower 20-30g, 45-55g angelica, 45-55g peach kernel, 45-55g aconite, 45-55g Chuanxiong, 18-22g raw Aconitum, 4-6g frankincense, 4-6g myrrh, 8-12g borneol, Menthol 4-6g. The cream for external use prepared by the invention can effectively improve the inflammation of bone joints and surrounding synovium, accelerate blood circulation, eliminate symptoms such as joint swelling and pain, movement disorder, alleviate the disease, have few adverse reactions, and are easy to carry for patients.

Description

External cream for treating osteoarthritis and preparation method thereof

technical field

The invention relates to a medicament for treating osteoarthritis and a preparation method thereof, in particular to an externally used medicament for treating osteoarthritis and a preparation method thereof.

Background technique

Osteoarthritis is a common disease in orthopedics. At present, the development of drugs for osteoarthritis in modern medicine is still in the research stage. Some Western medicine drugs have many adverse reactions, and the side effects are obvious, which often bring great mental burden to patients. , and can not achieve a radical cure for the disease, and oral Chinese medicine makes patients often afraid of trouble and unwilling to accept it, and many medicines for external use are mostly imported medicines or medicines from foreign pharmaceutical companies, which do not have domestic intellectual property rights, and the curative effect is not very satisfactory. For example, in the existing patent literature, the application number is 99120466.2, the application date is December 27, 1999, the authorized announcement number is CN1301547, the announcement date is July 4, 2001, and the patentee is Wang Zhenyu's invention patent. Pain-relief plaster for arthritis, it uses Astragalus, Panax notoginseng, Eucommia ulmoides, Lingpi, Tuyuan, Chuanwu, Aconitum, whole insect, centipede, fleece-flower root, pangolin, leech, frankincense, myrrh, angelica, Rhizoma Chuanxiong, Salvia, Peach Kernel, Paeoniae Rubra, Miltifolia, Safflower, Dried Blood, Dipsacus, Sangjisi, Moutan Bark, Turmeric, Achyranthes Radix, Wujia Bark, Black Snake, Elephant Peel, Blood Charcoal, Ephedra, Asarum, Fangfeng, Duhuo, Baizhi, Nanxing, Rhubarb, Pueraria lobata, Miku, borneol, white mustard seeds and other traditional Chinese medicines are used as raw materials, boiled in a certain proportion, and have a certain effect on the pain caused by osteoarthritis or in relieving symptoms. But there are certain side effects, can not effectively improve bone joints and surrounding synovial inflammation, accelerate blood circulation, curative effect is not very satisfactory, can't reach the radical cure of disease; On September 5, 2002, the announcement number was CN1358527, the announcement date was July 17, 2002, and the patentee was Wu Zhengang's invention patent, which disclosed a kind of Zhuifeng Jiangu Pain Relief Ointment, which has the functions of promoting blood circulation, removing blood stasis, expelling wind It is an effective drug with the functions of dispelling cold, relaxing tendons and strengthening bones, reducing swelling and relieving pain. Applicable to: rheumatoid arthritis, femoral head necrosis, herniated intervertebral disc, cervical spondylosis, hyperosteogeny, sciatica, osteomyelitis, bone tuberculosis, osteoma, etc. It has the advantages of strong penetration and convenient use, but it also has certain side effects. It cannot effectively improve the inflammation of the bone joints and surrounding synovium, accelerate blood circulation, eliminate joint swelling and pain, movement disorders and other symptoms, and cannot achieve a radical cure for the disease. Not very satisfied.

Contents of the invention

The present invention aims at treating osteoarthritis drugs in the prior art, which cannot cure the disease, effectively improve the inflammation of bone joints and surrounding synovium, eliminate joint swelling and pain, and symptoms of movement disorders, and many drugs have obvious side effects and low curative effect. Very satisfactory problem, the topical cream for treating osteoarthritis and its preparation method are provided.

In order to solve the above technical problems, the present invention is solved through the following technical solutions:

The external cream for the treatment of osteoarthritis mainly adopts the raw materials of the following components according to parts by weight in every 1000 grams: 20-30g of safflower, 45-55g of angelica, 45-55g of peach kernel, 45-55g of aconite, 45-55g of chuanxiong, Raw Aconitum 18-22g, frankincense 4-6g, myrrh 4-6g, borneol 8-12g, menthol 4-6g. The external cream for treating osteoarthritis prepared by these raw materials according to the weight portion can effectively improve the inflammation of bone joints and surrounding synovium, and eliminate joint swelling and pain and movement disorder symptoms.

As a preference, the external cream for the treatment of osteoarthritis mainly adopts the raw materials of the following components in parts by weight per 1000 grams: 25g of safflower, 50g of angelica, 50g of peach kernel, 50g of aconite, 50g of Chuanxiong, and 20g of raw Aconiti , frankincense 5g, myrrh 5g, borneol 10g, menthol 5g. The external cream for treating osteoarthritis prepared by these raw materials according to the weight portion can effectively improve the inflammation of bone joints and surrounding synovium, and eliminate joint swelling and pain and movement disorder symptoms.

As a preference, the external cream for treating osteoarthritis adopts the raw materials of the following components in parts by weight per 1000 grams: 23g of safflower, 48g of angelica, 47g of peach kernel, 46g of aconite, 47g of Rhizoma Chuanxiong, 19g of raw Aconitum aconitum, Made frankincense 5.5g, made myrrh 5.5g, borneol 9g, menthol 5.5g. The external cream for treating osteoarthritis prepared by these raw materials according to the weight part is more effective in improving the inflammation of bone joints and surrounding synovium, and eliminating joint swelling and pain and movement disorder symptoms.

As preferably, the external cream for treating osteoarthritis adopts the raw materials of the following components in parts by weight per 1000 grams: 28g of safflower, 53g of angelica, 52g of peach kernel, 53g of aconite, 54g of Chuanxiong, 21g of raw aconitum, Made frankincense 4.5g, made myrrh 4.5g, borneol 9g, menthol 4.5g. The external cream for treating osteoarthritis prepared by these raw materials according to the weight portion can more effectively improve the inflammation of bone joints and surrounding synovium, and eliminate joint swelling and pain and movement disorder symptoms.

Because among the above-mentioned raw materials, the medicinal effect of safflower is good at dredging the meridians, and it is a medicine for qi in the blood. It can relieve and nourish, and each has its own wonderful meaning; The effect of removing blood stasis, moistening dryness and smoothing intestines is arranged. Treatment of amenorrhea, abdominal mass, febrile disease, blood accumulation, wind arthralgia, malaria, bruises, blood stasis, swelling and pain, blood dryness and constipation; Aconite has the functions of dispelling cold and relieving pain, warming the middle and removing cold; Chuanxiong has the functions of promoting blood circulation, Expelling wind and relieving pain, opening depression and drying dampness and other effects; expelling wind and removing dampness, warming meridian and relieving pain. Shengchuanwu is used for wind-cold-damp arthralgia, joint pain, cold pain in trusted subordinates, and pain caused by cold colic; frankincense is pungent, warm and fragrant, can promote the qi in blood, has strong pain relief, and can relax tendons and activate collaterals; making myrrh can disperse blood and remove blood stasis, Reducing swelling and relieving pain, treating falls, gold sores, muscles and bones, all pains in trusted subordinates, lumps in the abdomen, amenorrhea, carbuncle, swelling and pain, hemorrhoids, and visual impairment; Analgesic effect; menthol can selectively stimulate the cold receptors of human skin or mucous membranes, produce cold reflex and cold sensation, cause skin and mucous membrane blood vessels to constrict, and also cause contraction of blood vessels in deep tissues to produce therapeutic effects. External use can Anti-inflammatory, relieve pain, relieve itching, promote blood circulation, reduce edema, etc.; therefore, the external cream for treating osteoarthritis made by the combination of this raw material can effectively improve the inflammation of bone joints and surrounding synovium, eliminate joint swelling and pain, and movement disorders Symptoms, satisfactory curative effect.

The specific steps of the preparation method of the external cream for the treatment of osteoarthritis are as follows:

Step 1: Weigh safflower, angelica, peach kernel, make aconite, chuanxiong, raw chuanwu, make frankincense, make myrrh, borneol, menthol, set aside;

Step 2: after pulverizing frankincense and myrrh, soak them in methyl salicylate, absorb the supernatant, and set aside;

Step 3: extract volatile oil from Angelica and Rhizoma Chuanxiong by co-water distillation, and set aside;

Step 4: decoct the dregs of Angelica Sinensis and Rhizoma Chuanxiong obtained by the co-water distillation method with the safflower, peach kernel, aconite, and raw Chuanwu in water, and filter to obtain the decoction, and reduce the decoction Concentrate under pressure to the liquid extract whose relative density is 1.08, set aside;

Step 5: Mix the obtained supernatant and volatile oil with pulverized menthol and borneol, and then add the oil phase matrix;

The sixth step: add the aqueous matrix to the liquid extract obtained;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

Preferably, the oil phase base can be any one of stearyl alcohol, monoethylene glycol or liquid petrolatum.

Preferably, the aqueous phase matrix is glycerin.

Preferably, the cream in the preparation method of the external cream for treating osteoarthritis is O-type or W-type.

According to the technical solution of the present invention, it can effectively improve the inflammation of bone joints and surrounding synovium, accelerate blood circulation, eliminate symptoms such as joint swelling, pain, and movement disorders, relieve the disease, have very few adverse reactions, and can be used by patients and is convenient to carry.

Description of drawings

Fig. 1 is a preparation process diagram of a topical cream for treating osteoarthritis.

Detailed ways

Below in conjunction with accompanying drawing 1 and specific embodiment the present invention is described in further detail:

Embodiment 1, the external cream for the treatment of osteoarthritis, the raw materials of the following components are mainly taken according to parts by weight in every 1000 grams: safflower 25g, angelica 50g, peach kernel 50g, aconite 50g, chuanxiong 50g, raw aconitum 20g, Make frankincense 5g, make myrrh 5g, borneol 10g, menthol 5g, and above-mentioned raw material is mixed with 1000g external cream Sijinshu cream.

The external cream preparation method for the treatment of osteoarthritis, as shown in Figure 1, the concrete steps are as follows:

Step 1: Weigh 25g safflower, 50g angelica, 50g peach kernel, 50g aconite, 50g chuanxiong, 20g raw aconitum, 5g frankincense, 5g myrrh, 10g borneol, 5g menthol, set aside;

Step 2: crush 5 g of frankincense and 5 g of myrrh and impregnate with methyl salicylate, take supernatant 1 and set aside;

Step 3: Extract volatile oil 2 from 50g Angelica sinensis and 50g Chuanxiong Rhizoma Rhizoma Chuanxiong through co-water distillation, and set aside;

Step 4: decoct the dregs obtained from angelica and chuanxiong by co-water distillation with 25g safflower, 50g peach kernel, 50g aconite, 20g raw chuanwu, and then extract and filter to obtain the decoction, and decoct The solution is concentrated under reduced pressure to a liquid extract 3 with a relative density of 1.08, which is set aside;

Step 5: Mix the obtained supernatant 1 and volatile oil 2 with crushed 5 g of menthol and 10 g of borneol, and then add the oil phase matrix stearyl alcohol;

The sixth step: adding the obtained liquid extract 3 to the aqueous matrix;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

The external cream for treating osteoarthritis prepared by the method can effectively improve the inflammation of bone joints and surrounding synovium, eliminate joint swelling and pain, and movement disorder symptoms, has satisfactory curative effect, few adverse reactions, and is easy to use and carry for patients.

Embodiment 2, the external cream for the treatment of osteoarthritis takes the raw materials of the following components in parts by weight in every 1000 grams: 23g of safflower, 48g of angelica, 47g of peach kernel, 46g of aconite, 47g of Chuanxiong, 19g of raw Aconitum aconitum, and frankincense 5.5g, myrrh 5.5g, borneol 9g, menthol 5.5g.

The external cream preparation method for the treatment of osteoarthritis, as shown in Figure 1, the concrete steps are as follows:

Step 1: Weigh 23g safflower, 48g angelica, 47g peach kernel, 46g aconite, 47g chuanxiong, 19g raw aconitum, 5.5g frankincense, 5.5g myrrh, 9g borneol, 5.5g menthol, set aside;

Step 2: crush 5.5g of frankincense and 5.5g of myrrh, impregnate with methyl salicylate, absorb supernatant 1, and set aside;

Step 3: Extract volatile oil 2 from 48g Angelica sinensis and 47g Chuanxiong Rhizoma Rhizoma Chuanxiong through co-water distillation, and set aside;

The fourth step: decoct the dregs obtained by co-water distillation of angelica and chuanxiong with 23g of safflower, 47g of peach kernels, 46g of aconite, 19g of raw chuanwu, and then extract and filter to obtain the decoction. The solution is concentrated under reduced pressure to a liquid extract 3 with a relative density of 1.08, which is set aside;

Step 5: Mix the obtained supernatant 1 and volatile oil 2 with crushed 5.5g menthol and 9g borneol, and then add the oil phase matrix stearyl alcohol;

The sixth step: adding the obtained liquid extract 3 to the aqueous matrix;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

The external cream for treating osteoarthritis prepared by the method can effectively improve the inflammation of bone joints and surrounding synovium, eliminate joint swelling and pain, and movement disorder symptoms, has satisfactory curative effect, few adverse reactions, and is easy to use and carry for patients.

Embodiment 3, the external cream for treating osteoarthritis takes the raw materials of the following components in parts by weight per 1000 grams: 28g of safflower, 53g of angelica, 52g of peach kernel, 53g of aconite, 54g of Chuanxiong, 21g of raw aconitum, and frankincense 4.5g, myrrh 4.5g, borneol 9g, menthol 4.5g.

The external cream preparation method for the treatment of osteoarthritis, as shown in Figure 1, the concrete steps are as follows:

Step 1: Weigh 28g safflower, 53g angelica, 52g peach kernel, 53g aconite, 54g chuanxiong, 21g raw aconitum, 4.5g frankincense, 4.5g myrrh, 9g borneol, 4.5g menthol, set aside;

Step 2: crush 4.5g of frankincense and 4.5g of myrrh, impregnate with methyl salicylate, absorb supernatant 1, and set aside;

Step 3: Extract volatile oil 2 from 53g Angelica sinensis and 54g Rhizoma Chuanxiong through co-water distillation, and set aside;

Step 4: Decoct the dregs obtained from angelica and chuanxiong by co-water distillation with 28g of safflower, 52g of peach kernel, 53g of aconite, 21g of raw chuanwu, and then extract and filter to obtain the decoction. The solution is concentrated under reduced pressure to a liquid extract 3 with a relative density of 1.08, which is set aside;

Step 5: Mix the obtained supernatant 1 and volatile oil 2 with pulverized 4.5g menthol and 9g borneol, and then add the oil phase matrix stearyl alcohol;

The sixth step: adding the obtained liquid extract 3 to the aqueous matrix;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

Embodiment 4, the external cream for treating osteoarthritis takes the raw materials of the following components in parts by weight in every 1000 grams: 20g of safflower, 45g of angelica, 45g of peach kernel, 45g of aconite, 45g of Chuanxiong, 18g of raw Aconitum aconitum, and frankincense 4g, myrrh 4g, borneol 8g, menthol 4g.

The external cream preparation method for the treatment of osteoarthritis, as shown in Figure 1, the concrete steps are as follows:

Step 1: Weigh 20g safflower, 45g angelica, 45g peach kernel, 45g aconite, 45g chuanxiong, 18g raw aconitum, 4g frankincense, 4g myrrh, 8g borneol, 4g menthol, set aside;

Step 2: crush 4 g of frankincense and 4 g of myrrh, impregnate with methyl salicylate, absorb supernatant 1, and set aside;

Step 3: Extract volatile oil 2 from 45g Angelica sinensis and 45g Chuanxiong Rhizoma Rhizoma Chuanxiong through co-water distillation, and set aside;

Step 4: decoct the dregs obtained from angelica and chuanxiong by co-water distillation with 20g safflower, 45g peach kernels, 45g aconite, 18g raw chuanwu, and then extract and filter to obtain the decoction. The liquid was concentrated under reduced pressure to liquid extract 3, and set aside;

Step 5: Mix the obtained supernatant 1 and volatile oil 2 with pulverized 4g menthol and 8g borneol, and then add the oil phase matrix stearyl alcohol;

The sixth step: adding the obtained liquid extract 3 to the aqueous matrix;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

Embodiment 5, the external cream for the treatment of osteoarthritis takes the raw materials of the following components in parts by weight per 1000 grams: 30g of safflower, 55g of angelica, 55g of peach kernel, 55g of aconite, 55g of chuanxiong, 22g of raw aconitum, and frankincense 6g, myrrh 6g, borneol 12g, menthol 6g.

The external cream preparation method for the treatment of osteoarthritis, as shown in Figure 1, the concrete steps are as follows:

Step 1: Weigh 30g safflower, 55g angelica, 55g peach kernel, 55g aconite, 55g chuanxiong, 22g raw aconitum, 6g frankincense, 6g myrrh, 12g borneol, 6g menthol, set aside;

Step 2: crush 6 g of frankincense and 6 g of myrrh, impregnate with methyl salicylate, absorb supernatant 1, and set aside;

Step 3: Extract volatile oil 2 from 55g Angelica sinensis and 55g Chuanxiong Rhizoma Rhizoma Chuanxiong through co-water distillation, and set aside;

Step 4: decoct the dregs obtained by co-water distillation of angelica and chuanxiong with 30g of safflower, 55g of peach kernels, 55g of aconite, 22g of raw chuanwu, and then extract and filter to obtain a decoction. The liquid was concentrated under reduced pressure to liquid extract 3, and set aside;

Step 5: Mix the obtained supernatant 1 and volatile oil 2 with 6 g of pulverized menthol and 12 g of borneol, and then add the oil phase matrix stearyl alcohol;

The sixth step: adding the obtained liquid extract 3 to the aqueous matrix;

Step 7: Mix and stir the solutions obtained in the fifth and sixth steps together to make a cream, and then pack it into a finished cream for external use for treating osteoarthritis.

Further set forth the beneficial effect of medicine of the present invention by test example below:

Test example 1, the clinical observation of patient's osteoarthritis treated with cream for external use of the present invention:

1. Clinical data

The subjects were divided into 2 groups according to the order of treatment, 30 cases in the treatment group and 10 cases in the control group. The symptoms of the patients were divided as follows:

Early stage: osteosclerosis or osteophyte, no joint space narrowing, 14 cases;

Mid-term: narrow or disappearing joint space, 12 cases;

Late stage: wear or loss of tibial load-bearing surface, 14 cases.

2. Patient symptoms

Knee arthritis is mainly characterized by pain and stiffness in the early stage, alternating unilaterally or bilaterally. Deep pain and soreness in the affected joints, aggravated by long-distance walking, strenuous exercise, cold or rainy weather, weak knees, weakness, easy to fall, difficulty squatting and going up and down stairs, inability to hold steady and obvious joint gelation , joint swelling during physical examination, sometimes accompanied by joint effusion, which can be a small amount of effusion or a large amount of effusion, the floating patellar test is positive, joint muscle atrophy, bone sound and friction sound during joint activities, and there are different degrees of activity limitation and muscle pain. Spasm, secondary muscular atrophy may occur in a small number of patients in the later stage, and joint deformity occurs in severe cases, and sometimes loose bodies in the joint can be touched.

3. Therapeutic method: sub-treatment group and control group, wherein the treatment group is divided into three groups of people according to the embodiment, and the external cream used is made by the proportioning raw materials and methods of embodiments 1, 2 and 3 respectively.

a) Treatment group: use the external application of the external cream for the treatment of osteoarthritis of the present invention, the external application of the external cream for the treatment of osteoarthritis is our hospital's self-made traditional Chinese medicine external preparation, adopt external application therapy along the meridians, and the external application parts are the front, rear and inner thighs. , lateral and corresponding meridian points rather than knee joints, such as Heding point, Yanglingquan, Xuehai, etc. External application for 1 to 3 days, 7 days as a course of treatment, 3-5 courses of treatment.

b) control group

Give Qianshan Huoxue Plaster for external application, Qianshan Huoxue Plaster, Approval Number: Z20025596, which is a black plaster spread on cloth, is suitable for promoting blood circulation and removing blood stasis, relaxing tendons and collaterals, reducing swelling and relieving pain. For joint swelling, pain, unfavorable activities, and bruises, waist, knee osteoarthritis see the above symptoms. External application for 1 to 3 days, 7 days as a course of treatment, 3-5 courses of treatment.

4. Curative effect standard

Recovery: the pain disappeared completely, the function returned to normal, the deformity was corrected, and there was no discomfort.

Significant effect: the pain basically disappeared, the function returned to normal, the deformity was basically corrected, and there was discomfort in case of weather changes.

Improvement: Pain relieved, self-care is basic, function has not returned to normal, deformity is basically corrected, and there is discomfort when the weather changes.

Ineffective: Pain was not relieved and symptoms were not improved.

5. Treatment outcome

Both the treatment group and the control group were evaluated according to the above criteria after 5 weeks of treatment. The therapeutic effects of the two groups are as follows:

Table 1: Comparison of treatment results between the two groups

Group Number of People Cured Significantly Effective Effective Invalid Effective Rate

therapy group:

(Example 1) 10 4 4 1 1 1 90%

(Example 2) 10 5 3 1 1 1 90%

(Example 3) 10 6 3 3 1 0 100%

Control group: 10 3 3 3 2 2 80%

In summary, as can be seen from Table 1, the total effective rate of the treatment group is 90%, the cure rate is 50%, the marked rate is 30%, the effective rate is 10%, and the invalid rate is 10%, while the total effective rate of the control group is 80%, and the cure rate is 30%. , effective rate 30%, effective rate 20%, invalid 10%, the above shows that the cream for external use of the present invention has significant curative effect and good long-term effect on knee osteoarthritis, can alleviate pathology, prevent the development of the course of disease, and treat knee joint The curative effect of inflammation is better than that of Qianshan Huoxue Ointment.

In a word, the above descriptions are only preferred embodiments and test examples of the present invention, and all equivalent changes and modifications made according to the scope of the patent application of the present invention shall fall within the scope of the patent of the present invention.

Claims (5)

1. treat the external-application cream of osteoarthritis, it is characterized in that: the every 1000g of described external-application cream takes the crude drug of following component: Flos Carthami 20-30g, Radix Angelicae Sinensis 45-55g, Semen Persicae 45-55g, Radix Aconiti Lateralis Preparata 45-55g, Rhizoma Chuanxiong 45-55g, Radix Aconiti 18-22g, Olibanum (processed) 4-6g, Myrrha (processed) 4-6g, Borneolum Syntheticum 8-12g, Mentholum 4-6g, its preparation method comprises the following steps:

The first step: take by weighing Flos Carthami, Radix Angelicae Sinensis, Semen Persicae, Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Aconiti, Olibanum (processed), Myrrha (processed), Borneolum Syntheticum, Mentholum, standby;

Second step: Olibanum (processed), Myrrha (processed) are pulverized the back with the methyl salicylate dipping, draw supernatant (1), standby;

The 3rd step: Radix Angelicae Sinensis, Rhizoma Chuanxiong with being total to hydrodistillation, are extracted volatile oil (2), standby;

The 4th step: with Radix Angelicae Sinensis, Rhizoma Chuanxiong with Flos Carthami, Semen Persicae, Radix Aconiti Lateralis Preparata, the Radix Aconiti of the medicinal residues of hydrodistillation gained altogether and described weight proportion decoct with water, filter decoction liquor, it is 1.08 fluid extract (3) that decoction liquor is evaporated to relative density, standby;

The 5th step: supernatant (1), volatile oil (2) with gained, mix with Mentholum of having pulverized and Borneolum Syntheticum, add oil phase substrate again, described oil phase substrate is octadecanol or monoethylene glycol;

The 6th step: will add aqueous phase substrate in the fluid extract (3) of gained, described aqueous phase substrate is a glycerol;

The 7th step: the solution of gained in the 5th step and the 6th step put be mixed together, stir evenly, make ointment, be packaged into the external-application cream finished product for the treatment of osteoarthritis again.

2. the external-application cream of treatment osteoarthritis according to claim 1, it is characterized in that: the every 1000g of described external-application cream takes the crude drug of following component: Flos Carthami 25g, Radix Angelicae Sinensis 50g, Semen Persicae 50g, Radix Aconiti Lateralis Preparata 50g, Rhizoma Chuanxiong 50g, Radix Aconiti 20g, Olibanum (processed) 5g, Myrrha (processed) 5g, Borneolum Syntheticum 10g, Mentholum 5g.

3. the external-application cream of treatment osteoarthritis according to claim 1, it is characterized in that: the every 1000g of described external-application cream takes the crude drug of following component: Flos Carthami 23g, Radix Angelicae Sinensis 48g, Semen Persicae 47g, Radix Aconiti Lateralis Preparata 46g, Rhizoma Chuanxiong 47g, Radix Aconiti 19g, Olibanum (processed) 5.5g, Myrrha (processed) 5.5g, Borneolum Syntheticum 9g, Mentholum 5.5g.

4. the external-application cream of treatment osteoarthritis according to claim 1, it is characterized in that: the every 1000g of described external-application cream takes the crude drug of following component: Flos Carthami 28g, Radix Angelicae Sinensis 53g, Semen Persicae 52g, Radix Aconiti Lateralis Preparata 53g, Rhizoma Chuanxiong 54g, Radix Aconiti 21g, Olibanum (processed) 4.5g, Myrrha (processed) 4.5g, Borneolum Syntheticum 9g, Mentholum 4.5g.

5. according to claim 1 or 2 or the preparation method of the external-application cream of 3 or 4 described treatment osteoarthritis, it is characterized in that: it comprises the following steps:

The first step: take by weighing Flos Carthami, Radix Angelicae Sinensis, Semen Persicae, Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, Radix Aconiti, Olibanum (processed), Myrrha (processed), Borneolum Syntheticum, Mentholum, standby;

Second step: Olibanum (processed), Myrrha (processed) are pulverized the back with the methyl salicylate dipping, draw supernatant (1), standby;

The 3rd step: Radix Angelicae Sinensis, Rhizoma Chuanxiong with being total to hydrodistillation, are extracted volatile oil (2), standby;

The 4th step: with Radix Angelicae Sinensis, Rhizoma Chuanxiong with Flos Carthami, Semen Persicae, Radix Aconiti Lateralis Preparata, the Radix Aconiti of the medicinal residues of hydrodistillation gained altogether and described weight proportion decoct with water, filter decoction liquor, it is 1.08 fluid extract (3) that decoction liquor is evaporated to relative density, standby;

The 5th step: supernatant (1), volatile oil (2) with gained, mix with Mentholum of having pulverized and Borneolum Syntheticum, add oil phase substrate again, described oil phase substrate is octadecanol or monoethylene glycol;

The 6th step: will add aqueous phase substrate in the fluid extract (3) of gained, described aqueous phase substrate is a glycerol;

The 7th step: the solution of gained in the 5th step and the 6th step put be mixed together, stir evenly, make ointment, be packaged into the external-application cream finished product for the treatment of osteoarthritis again.

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