CN101584740A - Traditional Chinese medical composition capable of tonifying Qi of the kidney, nourishing blood and promoting blood circulation, and a preparation method thereof - Google Patents
Traditional Chinese medical composition capable of tonifying Qi of the kidney, nourishing blood and promoting blood circulation, and a preparation method thereof Download PDFInfo
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- CN101584740A CN101584740A CNA2009100993795A CN200910099379A CN101584740A CN 101584740 A CN101584740 A CN 101584740A CN A2009100993795 A CNA2009100993795 A CN A2009100993795A CN 200910099379 A CN200910099379 A CN 200910099379A CN 101584740 A CN101584740 A CN 101584740A
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Abstract
The invention relates to a traditional Chinese medical composition capable of tonifying Qi of the kidney, nourishing blood and promoting blood circulation, and a preparation method thereof. The product is mainly composed of aweto, angelica, hemlock parsley, radix codonopsitis and licorice root. The preparation method comprises the steps of uniformly mixing above substances and extracts thereof in a certain ratio, drying, sterilizing and adding a proper amount of medicinal auxiliary material to prepare oral preparation. The invention uses relatively advanced technical conditions, ensures the quality and curative effect of the product, tonifies Qi of the kidney while nourishing blood and promoting blood circulation, and can effectively treat the diseases including female irregular menstruation, postpartum weakness, anemia and the like.
Description
Technical field
The Chinese medicine composition that the present invention relates to, specifically, relate to a kind ofly tonify Qi of the kidney, the Chinese medicine composition of nourshing blood and promoting blood circulation and preparation method thereof, belong to the field of medicine technology.
Background technology
Gynaecopathia such as menoxenia, anemia, puerperal blood deficiency weak etc. be to threaten the able-bodied common disease of current women, brought great misery for numerous women.
The traditional Chinese medical science thinks that blood is that the effect of water paddy process gas is transformed, and its generation and the heart, spleen, stomach, kidney have confidential relation.The deficiency of vital energy usually can cause blood deficiency, and blood deficiency also has the deficiency of vital energy to exist; To take into account QI invigorating when enriching blood.The prescription of enriching blood at present commonly used has SIWU TANG, Radix Angelicae Sinensis decoction for tonifying blood, decoction of ten powerful tonics etc. and the Chinese patent medicine Siwu mixture that forms of exploitation, blood-bonifying Chinese angelica essence, Radix Angelicae Sinensis regulating menstruation granule, bolus of ten powerful tonics etc. on this basis, all start with, thereby reach the purpose for the treatment of disease from nourishing qi and blood.
Yet the traditional Chinese medical science thinks that also the generation of nutrient blood not only comes from the biochemistry of the taste day after tomorrow, also must rely kidney essense as biochemistry originally.Kidney governing bones, store essential substances is given birth to marrow, and is very close with the generation of blood." interior warp " is loaded with " kidney producing bone marrow ", " bone person fu-viscera of marrow ", " the kidney dominating water metabolism, be subjected to the essence of five ZANG-organs and six FU-organs and hide it ".Ming Dynasty's Systematic Compilation of Internal Classic is pointed out: " marrow is similar ".The traditional Chinese medical science is promptly thought essence and blood sharing the same origin from ancient times, smartly can transform mutually with blood.Point out as the Sui Dynasty " General Treatise on the Cause and Symptoms of Diseases ": " institute of blood becomes also for kidney storing essence, smart person." illustrate that blood can turn to essence.Clear Zhang Zhi's acute hearing " companion mountain hall class is distinguished " is said: " the kidney being a water ZANG-organ, main store essential substances and change blood ".Illustrate that essence can turn to blood.So Ming Dynasty's Zhang Jingyue Systematic Compilation of Internal Classic is pointed out: " it is red and be blood that the seminal fluid of kidney is gone into the heartization ".In a word, the traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, essence and blood dirty, and main store essential substances is given birth to marrow, marrow homology.So the prosperity and decline of renal function directly affects the deficiency and excess of blood.
Modern medicine study is pointed out, a series of physiological situation can appear in female kidney deficiency, the generation that can cause erythropoietin of suffering from a deficiency of the kidney reduces, thereby making bone marrow stem cell form erythrocyte is suppressed, erythropoiesis reduces, hemopoietic function comes to harm, and deficiency of both QI and blood finally causes various gynaecopathias.It is exactly a kind of performance of suffering from a deficiency of the kidney that common pain in the low back and legs, the trick of women is afraid of cold.Menoxenia, frequent fetal movement, vaginal bleeding during pregnancy, infertile, amenorrhea, hyposexuality, clear and thin leucorrhea etc. all with suffer from a deficiency of the kidney relevantly, and can not be classified as gynaecopathia simply.To these treatment of conditions, should start with from the kidney invigorating, eliminate old complaint, just can reach long-range stable curative effect.
Chinese medicine composition of the present invention is developed at this clinical characters just, is formed by Cordyceps, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Codonopsis, Radix Glycyrrhizae prescription, tonifies Qi of the kidney in nourshing blood and promoting blood circulation, fundamentally improves the disease of QI and blood deficiency.Radix Angelicae Sinensis can nourshing blood and promoting blood circulation in the side, again can menstruction regulating and pain relieving, and the Cordyceps invigorating the lung and the kidney, the two is combined into monarch drug.The spleen and stomach provide the material basis of the acquired, source of generating QI and blood, and the Radix Codonopsis invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting, temper is prosperous and promoting generation of vital essence and blood is to be ministerial drug, plays spleen, kidney, gas, the blood merit with benefit altogether with monarch drug.Rhizoma Chuanxiong is the gas medicine in the blood, has both made full side's tonify without causing stagnation, and the merit of promoting blood circulation and stopping pain is arranged again, is adjuvant drug in the side.The Radix Glycyrrhizae QI invigorating and in, coordinating the actions of various ingredients in a prescription is messenger drug in the side.Above five kinds of Chinese medicine synergism, play altogether tonify Qi of the kidney, the effect of nourshing blood and promoting blood circulation.In addition, modern pharmacological research shows that ferulic acid, Radix Angelicae Sinensis volatile oil and Rhizoma Chuanxiong volatile oil all have the effect of anticoagulant, microcirculation improvement in the Radix Angelicae Sinensis, and the main effective ingredient in Radix Angelicae Sinensis and the Rhizoma Chuanxiong volatile oil is all ligustilide.But a lot of correlational studyes are found: the character of ligustilide and ferulic acid is all unstable, decomposes easily.Conventional extracting method is alcohol percolation method, steam distillation, takes longlyer, and volatile, the oxidation of effective ingredient influences drug effect.The present invention adopts supercritical CO
2Extracting process extracts volatile oil to address the above problem, and reaches the purpose that improves curative effect of medication simultaneously.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, avoid the limitation of known drug, with the kidney invigorating class medical material Cordyceps and the class medical material compatibility that fills blood, provide a kind of and tonify Qi of the kidney, the Chinese medicine composition of nourshing blood and promoting blood circulation, fundamentally treat menoxenia, puerperal asthenia, gynaecopathias such as anemia.
Chinese medicine composition disclosed by the invention is to be the oral formulations of main active ingredient and pharmaceutic adjuvant composition with extract of Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Codonopsis, Radix Glycyrrhizae and Cordyceps.
The weight portion ratio scope of Chinese medicine of respectively distinguishing the flavor of during medicine of the present invention is formed is: Cordyceps 30～150, Radix Angelicae Sinensis 55～160, Rhizoma Chuanxiong 20～80, Radix Codonopsis 40～70, Radix Glycyrrhizae 15～45.
Preferably respectively the distinguish the flavor of weight portion ratio of Chinese medicine of the present invention is: Cordyceps 80, Radix Angelicae Sinensis 125, Rhizoma Chuanxiong 45, Radix Codonopsis 60, Radix Glycyrrhizae 20.
Another technical problem to be solved by this invention is to provide the preparation method of above-mentioned Chinese medicine composition.In the present invention, we adopt supercritical CO
2Extracting process extracts the volatile oil in Radix Angelicae Sinensis and the Rhizoma Chuanxiong, this technology is simple, organic solvent-free is residual, the operating condition gentleness, avoided taking in the prior art longer, temperature is too high, and effective ingredient is volatile, oxidation and cause degradation problem under the drug effect, thereby has improved Radix Angelicae Sinensis greatly, Rhizoma Chuanxiong volatile oil composition yield and effective ingredient ligustilide and content of ferulic acid and stability.
Disclosed by the inventionly tonify Qi of the kidney, the preparation method of the Chinese medicine composition of nourshing blood and promoting blood circulation may further comprise the steps:
A. Cordyceps is pulverized, and it is standby to cross 80 mesh sieves;
B. get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.
C. with clear paste and " a " powder mixes, stir, add pharmaceutic adjuvant and granulate, drying, granulate is made granule, capsule or is pressed into tablet;
The described pharmaceutic adjuvant of above-mentioned " c " step is selected from filleies such as starch, dextrin, microcrystalline Cellulose, sucrose; Binding agents such as hydroxypropyl cellulose and other cellulose derivatives.
The relevant test of pesticide effectiveness of carrying out with Chinese medicine composition of the present invention:
(1) to the influence of puerperal rat Hb and RBC
Get 30 of SD rats that close on farrowing, be divided into three groups at random, 10 every group, since puerperal 6h by 2.5ml (100g
1) dosage respectively this medicine of ig-0.5%CMC suspension, YANGXUE DANGGUI JING solution and normal saline, 1 time/d, 10d continuously.Other gets 10 of normal SD rats, with method ig normal saline.The disconnected Mus tail blood sampling of 30min is measured Hb with the high iron processes of cyaniding after the last administration, measures RBC with the counting chamber direct counting method.The result shows that puerperal, rat Hb and RBC obviously reduced, and after this medicine and YANGXUE DANGGUI JING treatment, rat Hb and RBC all significantly raise, and wherein, this medication therapy groups is a little more than the YANGXUE DANGGUI JING group.
Table 1 influence of lactogenesis oral liquid of nourishing blood to puerperal rat Hb and RBC
| Group | Hb/g·L -1 | RBC/×10 12·L -1 |
| Normal control | 120.68±12.07 | 8.68±0.73 |
| The contrast in puerperal | 86.20±14.56* | 3.86±0.51* |
| YANGXUE DANGGUI JING solution | 121.20±8.82** | 5.53±0.70** |
| This medicine | 127.56±8.82** | 6.62±0.34** |
Compare * P＜0.01 with the normal control group; With matched group comparison in puerperal, * * P＜0.01
(2) to the influence of acute bleeding mice Hb and RBC
Get 40 of healthy mices, be divided into 4 groups at random, 10 every group.Except that the normal control group, all the other each groups cut off the most advanced and sophisticated 0.3cm of Mus tail, and Mus afterbody wound is immersed in 37 ℃ of warm water, lose the about 0.5ml of blood until mice, make model of blood dificiency.Press 0.2ml (10g then
-1) dosage respectively this medicine of ig-0.5%CMC suspension, YANGXUE DANGGUI JING solution and normal saline, 1 time/d, 10d continuously.The normal control group is with method ig normal saline.30min measures Hb and RBC value in the blood sampling of mice tail end after not inferior administration.The result shows that the blood deficiency that causes after this medicine and YANGXUE DANGGUI JING are lost blood to chmice acute all has certain blood tonification effect.
Table 2 influence of lactogenesis oral liquid of nourishing blood to acute bleeding mice Hb and RBC
| Group | Hb/g·L -1 | RBC/×10 12·L -1 |
| Normal control | 122.62±9.43 | 7.39±0.62 |
| The model contrast | 97.24±10.41* | 6.62±0.51* |
| YANGXUE DANGGUI JING solution | 110.03±13.22** | 7.35±0.25 |
| This medicine | 116.56±11.72** | 7.37±0.55 |
Compare * P＜0.01 with the normal control group; Compare * * P＜0.05 with model control group
(3) to the treatment of the mice of suffering from a deficiency of the kidney
Get 30 of healthy mices, be divided into 3 groups immediately, 10 every group.Except that the normal control group, all the other respectively organize every mice intragluteal injection hydrocortisone acetate 0.5mg every day, and administration is ten days altogether.Insufficiency of kidney-YANG symptoms such as appearance loses weight, dispirited, perpendicular hair is unclean, hogback is moving less, bradykinesia.The treatment group is irritated stomach by 10mL/kg and is given this medicine, successive administration 10 days; Non-treatment group and normal control group equivalent normal saline.This process and modeling are carried out the same period.Take off cervical vertebra in second day of last administration and put to death animal, win thymus, spleen, adrenal gland, weigh, be converted into organ coefficient (mg/g).Experimental result shows that model group mouse thymus, adrenal gland, spleen weight are starkly lower than the normal control group, show cause Mice with Spleen, the model of suffering from a deficiency of the kidney.And give with this Drug therapy after, mice with spleen deficiency body weight, body temperature all significantly go up, the mouse thymus of suffering from a deficiency of the kidney, adrenal gland, spleen weight also return to normally, show that this medicine can obviously improve the mice symptom of suffering from a deficiency of the kidney, and has better therapeutic effect to the mice of suffering from a deficiency of the kidney.
(4) to the treatment of syndrome of blood stasis rat
Get 40 of Wistar rats, be divided into 4 groups at random, 10 every group.A group treatment group: this medicine of 20mL/kg is irritated stomach; B group contrast medicine, XUEFU ZHUYU JIAONANG group 0.43g/kg; Model group: irritate the equivalent normal saline every day; C group normal control group: irritate the equivalent normal saline every day.Continuous irrigation stomach 10 days was irritated stomach after 1 hour on the 10th day, and each treated animal (except that the normal control group) is lumbar injection adrenalin hydrochloride 1mg/kg (normal saline solution dilution) all.Inject epinephrine the 11st day morning once more, after 1 hour, and 20% urethanes anesthesia (0.7mL/kg), abdominal aortic blood, 2.0%EDTA-Na
2Anticoagulant detects indexs of correlation such as hemorheological property.Blood viscosity detects the cone-plate method that adopts; Viscosity method under the low shearing rate is adopted in the erythrocyte aggregation test, and promptly the ratio of blood viscosity and blood plasma viscosity is erythrocyte aggregation index under the low shearing rate; Red cell deformability is measured with laser diffractometry and is measured, and adopts awl-board test structure, and red blood cell suspension adopts the PBS solution (pH=7.4) of 15%PVP, and the red blood cell suspension that dilutes is injected on the round platform, and during test, shear rate is by 100～1500s
-1Increase gradually, computer calculates deformable index automatically; As derivant, final concentration is 1 μ mol to platelet aggregation with ADP, and instrument shows 1min, 3min, 5min and maximum agglutination rate, with maximum agglutination rate result of calculation.The platelet adhesion reaction rate is calculated with glass ball method.Experimental result shows that medicine of the present invention reduces the rat blood viscosity to a certain extent, improves erythrocyte deformability, the effect and the model group that reduce erythrocyte aggregation index and anticoagulant relatively has significant difference (P＜0.01, P＜0.05).
Above-mentioned result of the test shows that beneficial effect of the present invention is:
Gynaecopathia such as menoxenia, anemia, puerperal blood deficiency weak etc. be to threaten the able-bodied common disease of current women, brought great misery for numerous women.And cause the reason of gynaecopathia numerous, and its pathomechanism is also comparatively complicated, and it is the many sick the most key pathomechanisms of planting of gynecological that blood stasis, the blood deficiency that causes of suffering from a deficiency of the kidney pointed out in clinical practice for many years.The traditional Chinese medical science thinks, " kidney storing essence, main bone, give birth to marrow ", " blood is essenceization ", " bone person fu-viscera of marrow ", " filling also of marrow person bone ", " sturdy skeleton, regular circulation of QI-blood ", " seminal fluid of grain rice and close and be the blood person, endosmosis in the bone sky, the tonification brains ".These records have illustrated the relation between kidney, bone marrow, the blood three.Bone marrow and hemopoietic have direct relation.Bone marrow is hidden in bone, is led by kidney again, and whether the function power of kidney, can influence the hemopoietic of bone marrow spermatogenesis.Jing-Yue Complete Works cloud: " kidney is the sea of essence and blood ".So the title of " essence and blood sharing the same origin " is arranged.Therefore, kidney governing reproduction on physiology, CHONG meridian being the blood pool, vessels of the uterus be what kidney and network in born of the same parents, uterus master menstruation and breed fetus.Suffering from a deficiency of the kidney a series of physiological situation to occur, and the generation that can cause erythropoietin of suffering from a deficiency of the kidney reduces, and is suppressed thereby make bone marrow stem cell form erythrocyte, erythropoiesis reduces, hemopoietic function comes to harm, and deficiency of both QI and blood finally causes various gynaecopathias.Therefore, in treatment, the kidney invigorating is a prerequisite.The present invention be according in recent years to the further investigation of Cordyceps composition and drug effect, again with nourish blood, invigorate blood circulation, QI invigorating class medical material Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Codonopsis, the meticulous compatibility of Radix Glycyrrhizae form.Above five kinds of Chinese medicine synergism, amount to tonify Qi of the kidney, the effect of nourshing blood and promoting blood circulation.In addition, the present invention adopts supercritical CO
2Extracting process extracts the volatile oil in Radix Angelicae Sinensis and the Rhizoma Chuanxiong, has improved both effective ingredient-ligustilides and content of ferulic acid stability, has guaranteed drug effect.
The specific embodiment
By specific embodiment given below, can further be well understood to the present invention, but they not limitation of the invention.
Embodiment 1:
Get Cordyceps 150g, Radix Angelicae Sinensis 60g, Rhizoma Chuanxiong 50g, Radix Codonopsis 70g, Radix Glycyrrhizae 25g.Cordyceps is pulverized, and it is standby to cross 80 mesh sieves; Get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.With clear paste and " a " powder mixes, stir, add starch, to granulate, drying incapsulates, and makes 1000, promptly.
Embodiment 2:
Get Cordyceps 100g, Radix Angelicae Sinensis 90g, Rhizoma Chuanxiong 25g, Radix Codonopsis 40g, Radix Glycyrrhizae 35g.Cordyceps is pulverized, and it is standby to cross 80 mesh sieves; Get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.With clear paste and " a " powder mixes, stir, add sucrose, to granulate, drying incapsulates, and makes 1000, promptly.
Embodiment 3:
Get Cordyceps 30g, Radix Angelicae Sinensis 120g, Rhizoma Chuanxiong 20g, Radix Codonopsis 50g, Radix Glycyrrhizae 15g.Cordyceps is pulverized, and it is standby to cross 80 mesh sieves; Get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.With clear paste and " a " powder mixes, stir, add dextrin, to granulate, drying incapsulates, and makes 1000, promptly.
Embodiment 4:
Get Cordyceps 150g, Radix Angelicae Sinensis 55g, Rhizoma Chuanxiong 80g, Radix Codonopsis 45g, Radix Glycyrrhizae 45g.Cordyceps is pulverized, and it is standby to cross 80 mesh sieves; Get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.With clear paste and " a " powder mixes, stir, add starch, to granulate, drying incapsulates, and makes 1000, promptly.
Embodiment 5:
Repeat the proportioning raw materials example of embodiment 1～4, difference is, the powder of Cordyceps and Radix Panacis Quinquefolii is mixed with clear paste, and after stirring, adding dextrin, each portion of sucrose, granulation, drying, packing promptly gets granule.
Embodiment 6:
Repeat the proportioning raw materials example of embodiment 1～4, difference is, the powder of Cordyceps and Radix Panacis Quinquefolii is mixed with clear paste, after stirring, adding starch, make granule after, add the mixing of Pulvis Talci 2%, 12% HPMC again after, be pressed into tablet.
Claims (5)
1, a kind ofly tonify Qi of the kidney, the Chinese medicine composition of nourshing blood and promoting blood circulation, it is characterized in that it is the solid orally ingestible of being made by following raw materials according: Cordyceps, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Codonopsis and Radix Glycyrrhizae.
2, Chinese medicine composition as claimed in claim 1 is characterized in that each proportion of raw materials is by weight: Cordyceps 30～150, Radix Angelicae Sinensis 55～160, Rhizoma Chuanxiong 20～80, Radix Codonopsis 40～70, Radix Glycyrrhizae 15～45.
3, Chinese medicine composition as claimed in claim 2 is characterized in that each proportion of raw materials is by weight: Cordyceps 80, Radix Angelicae Sinensis 125, Rhizoma Chuanxiong 45, Radix Codonopsis 60, Radix Glycyrrhizae 20.
4,, it is characterized in that described solid orally ingestible is tablet, capsule or granule as the arbitrary described Chinese medicine composition of claim 1～3.
5, a kind of as claim 1～4 arbitrary as described in the preparation method of Chinese medicine composition, may further comprise the steps:
A. Cordyceps is pulverized, it is standby to cross 80 mesh sieves;
B. get Radix Angelicae Sinensis, Rhizoma Chuanxiong pulverizing medicinal materials, use supercritical CO
2Extracting process extracts volatile oil, and wherein extraction temperature is 35 ℃～45 ℃, extracting pressure 35Mpa, and extraction time 2h, standby; Medicinal residues mix with Radix Codonopsis, Radix Glycyrrhizae, add 8～10 times of water gagings, reflux, extract, 3 times, and each 1.5 hours, merging filtrate, 60～70 ℃ in vacuum reclaims ethanol, continues to be concentrated into relative density and be 1.2～1.6 clear paste, and the Rhizoma Chuanxiong of use is fried with wine, and Radix Glycyrrhizae is used processed with honey.
C. with clear paste and " a " powder mixes, stir, add pharmaceutic adjuvant and granulate, drying, granulate is made granule, capsule or is pressed into tablet;
The described pharmaceutic adjuvant of above-mentioned " c " step is selected from filleies such as starch, dextrin, microcrystalline Cellulose, sucrose; Binding agents such as hydroxypropyl cellulose and other cellulose derivatives.
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