CN101569762A - Method for preparing quick hemostatic dressing - Google Patents
Method for preparing quick hemostatic dressing Download PDFInfo
- Publication number
- CN101569762A CN101569762A CNA2008101910121A CN200810191012A CN101569762A CN 101569762 A CN101569762 A CN 101569762A CN A2008101910121 A CNA2008101910121 A CN A2008101910121A CN 200810191012 A CN200810191012 A CN 200810191012A CN 101569762 A CN101569762 A CN 101569762A
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- CN
- China
- Prior art keywords
- mixture
- short fiber
- chitosan
- gram
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title abstract description 5
- 239000000835 fiber Substances 0.000 claims abstract description 36
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 229920001661 Chitosan Polymers 0.000 claims abstract description 20
- 239000000853 adhesive Substances 0.000 claims abstract description 13
- 230000001070 adhesive effect Effects 0.000 claims abstract description 13
- 239000000648 calcium alginate Substances 0.000 claims abstract description 12
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 12
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 12
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 12
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 10
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 9
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 8
- 229920002907 Guar gum Polymers 0.000 claims abstract description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 7
- 239000000665 guar gum Substances 0.000 claims abstract description 7
- 235000010417 guar gum Nutrition 0.000 claims abstract description 7
- 229960002154 guar gum Drugs 0.000 claims abstract description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000011505 plaster Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 8
- 238000001467 acupuncture Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 241000238366 Cephalopoda Species 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000005520 cutting process Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000004080 punching Methods 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 8
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 2
- 229940030225 antihemorrhagics Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 230000000025 haemostatic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a method for preparing a quick hemostatic dressing. The method comprises the following steps: 1, firstly, taking sodium carboxymethyl cellulose, carboxymethyl chitosan, polyethylene glycol and guar gum, grinding the bone of squid into powder, and evenly mixing the raw materials at the normal temperature to form a mixture A; 2, vibrating the mixture A obtained in the step 1 by a vibrating screen and then evenly pasting the mixture A on an adhesive medical tape; 3, cutting calcium alginate fiber and chitosan fiber into short fiber respectively, evenly mixing the short fiber, and punching the short fiber by a needle to form non-woven fabrics; and 4, covering the non-woven fabrics on the surface of the medical tape stuck with the mixture A, and finally forming a finished product. The quick hemostatic dressing has the advantages of low manufacturing cost, easy degradation, good hemostatic effect, and convenient use by a patient.
Description
Technical field
The present invention relates to a kind of manufacture method of quick hemostatic dressing.
Background technology
Accidental wound stomatorrhagia, hemorrhage, the injured hemorrhage method that all needs a kind of quick-acting haemostatic powder in soldier battlefield of traffic accident in the open air, but present market does not also occur carrying out the hemostatic Wound dressing fast.
Summary of the invention
The invention provides a kind of preparation method of quick hemostatic dressing, not only the cost of manufacture price is low for it, and easily degraded, treatment hemostatic wound effective, be convenient to the patient and use.
The present invention has adopted following technical scheme: a kind of preparation method of quick hemostatic dressing, and it may further comprise the steps: step 1, get sodium carboxymethyl cellulose, carboxymethyl chitosan, Polyethylene Glycol and guar gum, again the order fishbone powder is broken into powdery; Above-mentioned raw materials is uniformly mixed to form mixture A at normal temperatures; Step 2 evenly is added in mixed mixture A in the step 1 on the sticking medical air-permeable adhesive plaster through after the shaker vibration; Step 3 is got calcium alginate fibre and chitosan fiber, cuts into short fiber, and mix homogeneously after the shredding becomes non-woven fabrics with short fiber acupuncture then; Step 4 covers non-woven fabrics ventilative adhesive plaster then and is stained with on the surface of mixture A, forms finished product.
Sodium carboxymethyl cellulose is 100 grams in the step 1 of the present invention, and carboxymethyl chitosan is the 60-70 gram, and Polyethylene Glycol is the 10-15 gram, guar gum is the 3-5 gram, order fishbone 10-15 gram is broken into 200-300 purpose powdery with the order fishbone powder, and the particle diameter of mixture A is the 200-300 order.Adding mixture A in the step 2 of the present invention on every square metre the medical air-permeable adhesive plaster is that 60-80 restrains and make full and uniform being bonded on the medical air-permeable adhesive plaster of mixture A part.Calcium alginate fibre is 100 grams in the step 3 of the present invention, and chitosan fiber is 40 grams, and calcium alginate fibre and chitosan fiber cut into the short fiber that length is 65-80mm, mix homogeneously after the shredding, and described non-woven fabrics contains short fiber 120 grams for every square metre.
The present invention has following beneficial effect: the present invention adopts sodium carboxymethyl cellulose, Polyethylene Glycol, guar gum, the order fishbone powder, calcium alginate fibre, a kind of fast Absorption blood that material such as chitosan fiber and carboxymethyl chitosan is formed makes the hemostatic material of its a kind of high absorption of solidifying, its production cost is low, easily degraded, the treatment hemostatic wound is effective, being convenient to the patient uses, carboxymethyl chitosan of the present invention contacts the back by ion exchange with calcium alginate with wound fluid, discharge calcium ion and form surface gel to wound, the induced platelet activation produces the hemocyte somatomedin, play the hemostasis and the effect of accelerating wound healing, make the wound of bleeding profusely can be at 5-10 quick-acting haemostatic powder immediately in second.Sodium carboxymethyl cellulose among the present invention, carboxymethyl chitosan, poly-diethanol, pawl ear glue can absorb the hemorrhage of wound fast in a large number, the back expansion of sucking blood forms colloid, the order fishbone powder can have anastalsis, chitosan fiber and calcium alginate fibre have sterilization and form gelatinous integral body on the surface, can make it reach the hemostatic effect equally.
The specific embodiment
The invention provides a kind of preparation method of quick hemostatic dressing, it may further comprise the steps: step 1, get sodium carboxymethyl cellulose 100 grams, carboxymethyl chitosan 60-70 gram, Polyethylene Glycol 10-15 gram and guar gum 3-5 gram, again 10-15 is restrained the order fishbone powder and be broken into 200-300 purpose powdery, above-mentioned raw materials is uniformly mixed to form mixture A at normal temperatures, and the particle diameter of mixture A is the 200-300 order; Step 2, mixed mixture A in the step 1 evenly is added on the sticking medical air-permeable adhesive plaster through after the shaker vibration, adds mixture A60-80 gram on every square metre the medical air-permeable adhesive plaster and make full and uniform being bonded on the medical air-permeable adhesive plaster of mixture A part; Step 3 is got calcium alginate fibre 100 grams and chitosan fiber 40 grams, and calcium alginate fibre and chitosan fiber cut into the 65-80mm short fiber, and non-woven fabrics contains short fiber 120 grams for every square metre, and mix homogeneously after the shredding becomes non-woven fabrics with short fiber acupuncture then; Step 4 covers non-woven fabrics then on the ventilative adhesive plaster and is stained with on the surface of mixture A the formation finished product.
Claims (4)
1, a kind of preparation method of quick hemostatic dressing, it may further comprise the steps:
Step 1 is got sodium carboxymethyl cellulose, carboxymethyl chitosan, Polyethylene Glycol and guar gum, again the order fishbone powder is broken into powdery; Above-mentioned raw materials is uniformly mixed to form mixture A at normal temperatures;
Step 2 evenly is added in mixed mixture A in the step 1 on the sticking medical air-permeable adhesive plaster through after the shaker vibration;
Step 3 is got calcium alginate fibre and chitosan fiber, cuts into short fiber, and mix homogeneously after the shredding becomes non-woven fabrics with short fiber acupuncture then;
Step 4 covers non-woven fabrics ventilative adhesive plaster then and is stained with on the surface of mixture A, forms finished product.
2, the preparation method of quick hemostatic dressing according to claim 1, it is characterized in that sodium carboxymethyl cellulose is 100 grams in the step 1, carboxymethyl chitosan is the 60-70 gram, Polyethylene Glycol is the 10-15 gram, guar gum is the 3-5 gram, order fishbone 10-15 gram is broken into 200-300 purpose powdery with the order fishbone powder, and the particle diameter of mixture A is the 200-300 order.
3, the preparation method of quick hemostatic dressing according to claim 1 is characterized in that in the step 2 adding mixture A on every square metre the medical air-permeable adhesive plaster and is the 60-80 gram and makes full and uniform being bonded on the medical air-permeable adhesive plaster of mixture A part.
4, the preparation method of quick hemostatic dressing according to claim 1, it is characterized in that calcium alginate fibre is 100 grams in the step 3, chitosan fiber is 40 grams, calcium alginate fibre and chitosan fiber cut into the short fiber that length is 65-80mm, mix homogeneously after the shredding, described non-woven fabrics contains short fiber 120 grams for every square metre.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101910121A CN101569762A (en) | 2008-12-31 | 2008-12-31 | Method for preparing quick hemostatic dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101910121A CN101569762A (en) | 2008-12-31 | 2008-12-31 | Method for preparing quick hemostatic dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101569762A true CN101569762A (en) | 2009-11-04 |
Family
ID=41229330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101910121A Pending CN101569762A (en) | 2008-12-31 | 2008-12-31 | Method for preparing quick hemostatic dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101569762A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102580137A (en) * | 2012-03-07 | 2012-07-18 | 苏州美迪斯医疗运动用品有限公司 | Medical functional biological dressing and preparation method thereof |
| CN103721291A (en) * | 2013-12-19 | 2014-04-16 | 褚加冕 | Method for preparing fast haemostatic dressing |
| CN104144712A (en) * | 2011-11-25 | 2014-11-12 | 株式会社大塚制药工场 | Pharmaceutical composition for preventing adhesion or hemostasis |
| CN113855860A (en) * | 2021-10-20 | 2021-12-31 | 北京大学口腔医学院 | Method and equipment for preparing artificial bone block |
-
2008
- 2008-12-31 CN CNA2008101910121A patent/CN101569762A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104144712A (en) * | 2011-11-25 | 2014-11-12 | 株式会社大塚制药工场 | Pharmaceutical composition for preventing adhesion or hemostasis |
| CN102580137A (en) * | 2012-03-07 | 2012-07-18 | 苏州美迪斯医疗运动用品有限公司 | Medical functional biological dressing and preparation method thereof |
| CN103721291A (en) * | 2013-12-19 | 2014-04-16 | 褚加冕 | Method for preparing fast haemostatic dressing |
| CN113855860A (en) * | 2021-10-20 | 2021-12-31 | 北京大学口腔医学院 | Method and equipment for preparing artificial bone block |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20091104 |