CN101564471A - Preparation method of buccal tablets for treating laryngeal disease - Google Patents
Preparation method of buccal tablets for treating laryngeal disease Download PDFInfo
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- CN101564471A CN101564471A CNA2009100691511A CN200910069151A CN101564471A CN 101564471 A CN101564471 A CN 101564471A CN A2009100691511 A CNA2009100691511 A CN A2009100691511A CN 200910069151 A CN200910069151 A CN 200910069151A CN 101564471 A CN101564471 A CN 101564471A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 17
- 208000029951 Laryngeal disease Diseases 0.000 title claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 55
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 37
- 238000001035 drying Methods 0.000 claims abstract description 36
- 239000000284 extract Substances 0.000 claims abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000843 powder Substances 0.000 claims abstract description 21
- 238000003756 stirring Methods 0.000 claims abstract description 19
- 239000000706 filtrate Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 15
- 239000000314 lubricant Substances 0.000 claims abstract description 12
- 239000000945 filler Substances 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 241001534869 Terminalia Species 0.000 claims abstract description 10
- 239000000796 flavoring agent Substances 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 8
- 239000007779 soft material Substances 0.000 claims abstract description 8
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 7
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims abstract description 7
- 235000019634 flavors Nutrition 0.000 claims abstract description 7
- 238000000227 grinding Methods 0.000 claims abstract description 7
- 239000008101 lactose Substances 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims abstract description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 5
- 235000010355 mannitol Nutrition 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract description 3
- 241000001522 Terminalia chebula Species 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims description 18
- 239000008187 granular material Substances 0.000 claims description 18
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 14
- 239000010231 banlangen Substances 0.000 claims description 12
- 239000008517 radix Trichosanthis Substances 0.000 claims description 12
- 239000002671 adjuvant Substances 0.000 claims description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims description 7
- 244000293323 Cosmos caudatus Species 0.000 claims description 6
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 6
- 206010013786 Dry skin Diseases 0.000 claims description 6
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000012065 filter cake Substances 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 5
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 5
- 229960004998 acesulfame potassium Drugs 0.000 claims description 5
- 239000000619 acesulfame-K Substances 0.000 claims description 5
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000007968 orange flavor Substances 0.000 claims description 5
- 235000000346 sugar Nutrition 0.000 claims description 5
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 4
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 239000004376 Sucralose Substances 0.000 claims description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 4
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000019408 sucralose Nutrition 0.000 claims description 4
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 239000001116 FEMA 4028 Substances 0.000 claims description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 2
- 229960004853 betadex Drugs 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 238000007906 compression Methods 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 7
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract description 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 3
- 229940116229 borneol Drugs 0.000 abstract 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 3
- 235000013355 food flavoring agent Nutrition 0.000 abstract 2
- 240000005748 Achyranthes aspera Species 0.000 abstract 1
- 235000005517 Achyranthes aspera Nutrition 0.000 abstract 1
- 241000334160 Isatis Species 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 235000009330 Terminalia Nutrition 0.000 abstract 1
- 235000011517 Terminalia chebula Nutrition 0.000 abstract 1
- 241000218989 Trichosanthes Species 0.000 abstract 1
- 239000006286 aqueous extract Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005453 pelletization Methods 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 description 5
- 201000007100 Pharyngitis Diseases 0.000 description 4
- 229940046011 buccal tablet Drugs 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 241000220223 Fragaria Species 0.000 description 3
- 206010034038 Parotitis Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 208000016150 acute pharyngitis Diseases 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 206010044008 tonsillitis Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention relates to a preparation method of buccal tablets for treating laryngeal disease. The Chinese medicine raw materials include borneol, calculus bovis artifactus, pearl layer powder, subprostrate sophora, radix wikstroemae, achyranthes aspera, isatis root, forsythia, trichosanthes root, balloon flower, fructus gleditsiae and Terminalia Fructus chebulae, and the auxiliary materials include fillers and flavoring agents such as lactose, mannite, steviosin, essence and the like. The preparation comprises the steps of: firstly mixing 9 types of drugs according to quantity, adding water with the quantity of 5-10 times of the drugs, combining four times of the decoction liquid, concentrating the filtrate into thick paste, adding ethanol to lead the concentration of the thick paste to reach 65-80 percent, standing for 24h after uniform stirring, and obtaining dry extract a by concentrating and drying the filtrate; then concentrating and drying the aqueous extract of terminalia chebula retz to obtain dry extract b; including the borneol with cyclodextrin; uniformly mixing the dry extract a, the dry extract b and the inclusion compound of the borneol, adding the calculus bovis artifactus, pearl layer powder, the fillers and the flavoring agents, grinding and sifting the mixture, adding proper amount of 95 percent ethanol in the fine powder to prepare soft material, and pelletizing and drying the soft material; and finally sifting, stabilizing particles, adding lubricant according to quantity, mixing uniformly and tabletting. The preparation is simple, the flavor is favorable, the healing effect is exact and the effect is notable.
Description
Technical field
The present invention relates to a kind of preparation method of traditional Chinese medicine mouth buccal tablet, particularly a kind of preparation method that is used for the treatment of the buccal tablets for treating laryngeal disease of laryngopharyngeal diseases.
Technical background
At present, people use larynx disease curing capsule, are a kind of parotitis that is used for the treatment of, tonsillitis, acute pharyngitis, the Chinese patent medicine of acute episode of chronic pharyngitis and general laryngalgia.Obtain the favorable comment of extensive patients surplus the clinical practice ten over year.But its extraction process is simple, medicine single dose is big, and its quality control index is mainly thin layer chromatography, can not effectively control its product quality.
Therefore, providing a kind of and be convenient to take, the preparation method of the buccal tablets for treating laryngeal disease that is used for the treatment of laryngopharyngeal diseases of determined curative effect, is one of the current urgency of this field scientific research personnel problem to be solved.
Summary of the invention
The object of the present invention is to provide the preparation method of the buccal tablets for treating laryngeal disease of a kind of good mouthfeel, taking convenience, determined curative effect.
Implementation of the present invention is as follows for achieving the above object:
A kind of preparation method of buccal tablets for treating laryngeal disease is characterized in that implementation step comprises:
(1) get raw material ready by following weight portion:
15～20 parts of artificial Calculus Boviss, 200～300 parts of Radix Isatidis, 200～250 parts of Fructus Chebulaes,
200～300 parts of Radix Platycodoniss, 20～50 parts of Fructus Gleditsiae Abnormalis, 200～250 parts of Fructus Forsythiaes,
400～500 parts of Radix Trichosanthis, 15～20 parts of Margarita layer powder, 200～300 parts of Radix Eupatorii Chinensiss,
15～20 parts of Borneolum Syntheticums, 400～500 parts of Radix Sophorae Tonkinensiss, 400～500 parts of Radix Wikstroemae;
(2) get adjuvant ready by following weight portion:
80～150 parts of beta-schardinger dextrin-s, 500～800 parts of filleies, 3～10 parts of correctivess,
5～20 parts of lubricants, 5～10 parts in essence;
(3) by above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines in the raw material are mixed, add the water of 5～10 times of amounts at every turn, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration; Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 65%～80% volume by volume concentration, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a;
(4) terminalia flesh water concentration is contractd drying is made dry extract b;
(5) with the Borneolum Syntheticum beta-cyclodextrin inclusion compound;
(6) with the clathrate mixing of dry extract a, dry extract b, Borneolum Syntheticum, add artificial Calculus Bovis, Margarita layer powder and filler, correctives grinding and sieving according to quantity, fine powder adds the 95% volume by volume concentration ethanol of 10～30ml and makes soft material after moistening, granulates drying;
(7) granule that drying is the good granulate that sieves adds lubricant, tabletting behind the mixing according to quantity.
Filler in the described adjuvant of described step (2) is a kind of in lactose, Icing Sugar, mannitol, the calcium hydrogen phosphate or their mixture; Described correctives is a kind of in aspartame, acesulfame potassium, sucralose, the steviosin or their mixture; Described lubricant is a magnesium stearate; Described essence is a kind of in Herba Menthae essence, orange flavor essence, the strawberry essence or their mixture.
Described dry extract a, dry extract b adopt drying under reduced pressure, and temperature is 60 ℃～80 ℃.
The clathrate process of Borneolum Syntheticum is in the described step (5): Borneolum Syntheticum: beta-schardinger dextrin-=50～80: 300～500; Borneolum Syntheticum adds 20～40 times of 95% volume by volume concentration dissolve with ethanol; Beta-schardinger dextrin-adds 15～30 times of water and places in the container, is heated to 50～70 ℃ it is dissolved fully, adds the alcoholic solution of Borneolum Syntheticum while stirring; Add the back and continue to stir 2 hours, leave standstill 24 hours sucking filtration, filter cake is with 10～30ml, 95% volume by volume concentration washing with alcohol 3 times, 50 ℃ of dryings 2～4 hours.
Described step (4) Fructus Chebulae's water concentration compression method is the water that terminalia flesh is added 5～12 times of amounts, soaks half an hour, once decocts 2 hours, decocts 1～4 time.
The invention has the beneficial effects as follows: success of the present invention made the buccal tablet that can be accepted by the patient, improved the quality standard of existing prescription, more safe and reliable; Be mainly used in parotitis, tonsillitis, acute pharyngitis, acute episode of chronic pharyngitis and general laryngalgia.In the preparation process, wherein terminalia flesh extracts separately and has avoided tannin and other Chinese medicine ingredients to react and cause damage; Chinese medicine generally all compares the taste hardship in addition, and mouthfeel is not good, so the present invention adopts the method for cyclodextrin inclusion compound with Borneolum Syntheticum, has both prevented the distillation loss of Borneolum Syntheticum, has eliminated its poor taste again, kills two birds with one stone; And eliminated the bad mouthfeel of medicine by adding adjuvants such as lactose, steviosin.
In a word, preparation method of the present invention is simple, good mouthfeel, and taking convenience, determined curative effect, effect is remarkable; Simultaneously, be easy to carry, be widely used.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1 (every part by 1g)
Major ingredient:
Artificial Calculus Bovis 15g, Radix Isatidis 230g, Fructus Chebulae 230g,
Radix Platycodonis 230g, Fructus Gleditsiae Abnormalis 25g, Fructus Forsythiae 210g,
Radix Trichosanthis 410g, Margarita layer powder 15g, Radix Eupatorii Chinensis 210g,
Borneolum Syntheticum 15g, Radix Sophorae Tonkinensis 410g, Radix Wikstroemae 410g.
Adjuvant:
Beta-schardinger dextrin-80g, filler 550g, correctives 3g, lubricant 5g, essence 20g.
Above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines are added the water of 5 times of amounts, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration.Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 65% volume by volume concentration, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a.
Terminalia flesh adds the water of 5 times of amounts, soaks half an hour, decocts 2 hours; Add 5 times of water gagings again and decocted 2 hours, leach extracting solution; Merging filtrate concentrates and drying is made dry extract b.
Borneolum Syntheticum: beta-schardinger dextrin-=50: 300.Borneolum Syntheticum adds 20 times of 95% volume by volume concentration dissolve with ethanol.Beta-schardinger dextrin-adds 15 times of water to be put in the container, is heated to 50 ℃ and makes dissolving fully, adds the alcoholic solution of Borneolum Syntheticum while stirring.Adding the back continues to stir 2 hours.Leave standstill 24 hours sucking filtration.Filter cake is with 10～30ml, 95% volume by volume concentration washing with alcohol 3 times, 50 ℃ of dryings 2 hours.
Described dry extract a, dry extract b be drying under reduced pressure routinely, and temperature is 60 ℃～80 ℃.
Clathrate mixing with dry extract a, dry extract b, Borneolum Syntheticum; add artificial Calculus Bovis, Margarita layer powder and lactose, steviosin, acesulfame potassium, orange flavor grinding and sieving according to quantity; fine powder adds the 95% volume by volume concentration ethanol of 10～30ml and makes soft material routinely after moistening, granulates drying.
The granule that drying is the good granulate that sieves adds magnesium stearate, tabletting behind the mixing, promptly.
In the enforcement, the filler in the described adjuvant is a kind of in lactose, Icing Sugar, mannitol, the calcium hydrogen phosphate or their mixture; Described correctives is a kind of in aspartame, acesulfame potassium, sucralose, the steviosin or their mixture; Described lubricant is a magnesium stearate; Described essence is a kind of in Herba Menthae essence, orange flavor essence, the strawberry essence or their mixture.The mixing match of the above all kinds of mixture is to select arbitrarily.
Embodiment 2 (every part by 1g)
Major ingredient:
Artificial Calculus Bovis 16g, Radix Isatidis 250g, Fructus Chebulae 200g,
Radix Platycodonis 250g, Fructus Gleditsiae Abnormalis 30g, Fructus Forsythiae 220g,
Radix Trichosanthis 420g, Margarita layer powder 16g, Radix Eupatorii Chinensis 220g,
Borneolum Syntheticum 16g, Radix Sophorae Tonkinensis 420g, Radix Wikstroemae 420g.
Adjuvant:
Beta-schardinger dextrin-85g, filler 600g, correctives 6g, lubricant 6g, essence 15g.
Above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines are added the water of 6 times of amounts, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration.Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 70%, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a.
Terminalia flesh adds the water of 6 times of amounts, soaks half an hour, decocts 2 hours; Add 6 times of water gagings again and decocted 2 hours, leach extracting solution; Merging filtrate concentrates and drying is made dry extract b.
Borneolum Syntheticum: beta-schardinger dextrin-=55: 350.Borneolum Syntheticum adds 25 times of 95% dissolve with ethanol.16 times of water of beta-schardinger dextrin-power are put in the container, are heated to 52 ℃ and make dissolving fully, add the alcoholic solution of Borneolum Syntheticum while stirring.Adding the back continues to stir 2 hours.Leave standstill 24 hours sucking filtration.Filter cake is with an amount of washing of 95% ethanol 3 times, 50 ℃ of dryings 2 hours.
Clathrate mixing with dry extract a, dry extract b, Borneolum Syntheticum; add artificial Calculus Bovis, Margarita layer powder and calcium hydrogen phosphate, mannitol, steviosin, Herba Menthae essence grinding and sieving; fine powder adds that 95% ethanol of 10～30ml is an amount of makes soft material after moistening, granulates drying.
The granule that drying is the good granulate that sieves adds magnesium stearate, tabletting behind the mixing, promptly.
Other is with embodiment 1.
Embodiment 3 (every part by 1g)
Major ingredient:
Artificial Calculus Bovis 18g, Radix Isatidis 260g, Fructus Chebulae 220g,
Radix Platycodonis 260g, Fructus Gleditsiae Abnormalis 35g, Fructus Forsythiae 220g,
Radix Trichosanthis 440g, Margarita layer powder 18g, Radix Eupatorii Chinensis 260g,
Borneolum Syntheticum 18g, Radix Sophorae Tonkinensis 440g, Radix Wikstroemae 440g.
Adjuvant:
Beta-schardinger dextrin-100g, filler 650g, correctives 10g, lubricant 10g, essence 18g.
Above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines are added the water of 7 times of amounts, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration.Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 75%, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a.
Terminalia flesh adds the water of 7 times of amounts, soaks half an hour, decocts 2 hours; Add 7 times of water gagings again and decocted 2 hours, leach extracting solution; Merging filtrate concentrates and drying is made dry extract b.
Borneolum Syntheticum: beta-schardinger dextrin-=58: 330.Borneolum Syntheticum adds 29 times of 95% dissolve with ethanol.19 times of water of beta-schardinger dextrin-power are put in the container, are heated to 57 ℃ and make dissolving fully, add the alcoholic solution of Borneolum Syntheticum while stirring.Adding the back continues to stir 2 hours.Leave standstill 24 hours sucking filtration.Filter cake is with an amount of washing of 95% ethanol 3 times, 50 ℃ of dryings 2.5 hours.
With the clathrate mixing of dry extract a, dry extract b, Borneolum Syntheticum, add artificial Calculus Bovis, Margarita layer powder and Icing Sugar, sucralose, strawberry essence grinding and sieving, fine powder adds that 95% ethanol of 10～30ml is an amount of makes soft material after moistening, granulates drying.
The granule that drying is the good granulate that sieves adds magnesium stearate according to quantity, tabletting behind the mixing, promptly.
Other is with embodiment 1.
Embodiment 4 (every part by 1g)
Major ingredient:
Artificial Calculus Bovis 20g, Radix Isatidis 280g, Fructus Chebulae 245g,
Radix Platycodonis 280g, Fructus Gleditsiae Abnormalis 48g, Fructus Forsythiae 245g,
Radix Trichosanthis 475g, Margarita layer powder 20g, Radix Eupatorii Chinensis 280g,
Borneolum Syntheticum 20g, Radix Sophorae Tonkinensis 475g, Radix Wikstroemae 475g.
Adjuvant:
Beta-schardinger dextrin-140g, filler 665g, correctives 15g, lubricant 15g, essence 10g.
Above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines are added the water of 10 times of amounts, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration.Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 80%, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a.
Terminalia flesh adds the water of 8 times of amounts, soaks half an hour, decocts 2 hours; Add 8 times of water gagings again and decocted 2 hours, leach extracting solution; Merging filtrate concentrates and drying is made dry extract b.
Borneolum Syntheticum: beta-schardinger dextrin-=80: 500.Borneolum Syntheticum adds 40 times of 95% dissolve with ethanol.Beta-schardinger dextrin-adds 30 times of water to be put in the container, is heated to 70 ℃ and makes dissolving fully, adds the alcoholic solution of Borneolum Syntheticum while stirring.Adding the back continues to stir 2 hours.Leave standstill 24 hours sucking filtration.Filter cake is with an amount of washing of 95% ethanol 3 times, 50 ℃ of dryings 3 hours.
With the clathrate mixing of dry extract a, dry extract b, Borneolum Syntheticum, add artificial Calculus Bovis, Margarita layer powder and Icing Sugar, lactose, acesulfame potassium, orange flavor grinding and sieving, fine powder adds that 95% ethanol of 10～30ml is an amount of makes soft material after moistening, granulates drying.
The granule that drying is the good granulate that sieves adds magnesium stearate, tabletting behind the mixing, promptly.
Other is with embodiment 1.
Patient's use for convenience, the present invention is on the basis of capsule, the new technology of employing new technology is developed to a kind of buccal tablet with it.
This buccal tablet instructions of taking is: oral, one time 3～4,3 times on the one.After taking, the patient generally reflects good mouthfeel, taking convenience, and determined curative effect, effect is remarkable.
Above-mentioned detailed description of the preparation method of buccal tablets for treating laryngeal disease being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to limited range,, should belong within protection scope of the present invention therefore in the variation and the modification that do not break away under the general plotting of the present invention.
Claims (5)
1, a kind of preparation method of buccal tablets for treating laryngeal disease is characterized in that implementation step comprises:
(1) get raw material ready by following weight portion:
15～20 parts of artificial Calculus Boviss, 200～300 parts of Radix Isatidis, 200～250 parts of Fructus Chebulaes,
200～300 parts of Radix Platycodoniss, 20～50 parts of Fructus Gleditsiae Abnormalis, 200～250 parts of Fructus Forsythiaes,
400～500 parts of Radix Trichosanthis, 15～20 parts of Margarita layer powder, 200～300 parts of Radix Eupatorii Chinensiss,
15～20 parts of Borneolum Syntheticums, 400～500 parts of Radix Sophorae Tonkinensiss, 400～500 parts of Radix Wikstroemae;
(2) get adjuvant ready by following weight portion:
80～150 parts of beta-schardinger dextrin-s, 500～800 parts of filleies, 3～10 parts of correctivess,
5～20 parts of lubricants, 5～10 parts in essence;
(3) by above-mentioned amount Semen Chebulae, Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis, Radix Wikstroemae nine flavor medicines in the raw material are mixed, add the water of 5～10 times of amounts at every turn, decoct 4 times, each 3 hours, the merge extractive liquid, after-filtration; Filtrate is condensed into thick paste, adds ethanol and makes concentration of alcohol reach 65%～80% volume by volume concentration, leaves standstill after stirring evenly 24 hours, after the filtration the concentrated also drying of filtrate is made dry extract a;
(4) terminalia flesh water concentration is contractd drying is made dry extract b;
(5) with the Borneolum Syntheticum beta-cyclodextrin inclusion compound;
(6) with the clathrate mixing of dry extract a, dry extract b, Borneolum Syntheticum, add artificial Calculus Bovis, Margarita layer powder and filler, correctives grinding and sieving according to quantity, fine powder adds the 95% volume by volume concentration ethanol of 10～30ml and makes soft material after moistening, granulates drying;
(7) granule that drying is the good granulate that sieves adds lubricant, tabletting behind the mixing according to quantity.
2, the preparation method of buccal tablets for treating laryngeal disease according to claim 1 is characterized in that: the filler in the described adjuvant of step (2) is a kind of in lactose, Icing Sugar, mannitol, the calcium hydrogen phosphate or their mixture; Described correctives is a kind of in aspartame, acesulfame potassium, sucralose, the steviosin or their mixture; Described lubricant is a magnesium stearate; Described essence is a kind of in Herba Menthae essence, orange flavor essence, the strawberry essence or their mixture.
3, the preparation method of buccal tablets for treating laryngeal disease according to claim 1 is characterized in that: described dry extract a, dry extract b adopt drying under reduced pressure, and temperature is 60 ℃～80 ℃.
4, the preparation method of buccal tablets for treating laryngeal disease according to claim 1 is characterized in that: the clathrate process of Borneolum Syntheticum is in the described step (5): Borneolum Syntheticum: beta-schardinger dextrin-=50～80: 300～500; Borneolum Syntheticum adds 20～40 times of 95% volume by volume concentration dissolve with ethanol; Beta-schardinger dextrin-adds 15～30 times of water and places in the container, is heated to 50～70 ℃ it is dissolved fully, adds the alcoholic solution of Borneolum Syntheticum while stirring; Add the back and continue to stir 2 hours, leave standstill 24 hours sucking filtration, filter cake is with 10～30ml, 95% volume by volume concentration washing with alcohol 3 times, 50 ℃ of dryings 2～4 hours.
5, the preparation method of buccal tablets for treating laryngeal disease according to claim 1 is characterized in that: described step (4) Fructus Chebulae's water concentration compression method is the water that terminalia flesh is added 5～12 times of amounts, soaks half an hour, once decocts 2 hours, decocts 1～4 time.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357159A (en) * | 2011-10-18 | 2012-02-22 | 刘天岐 | Bezoar anticancer pill |
| CN109106747A (en) * | 2018-07-02 | 2019-01-01 | 宁夏医科大学 | A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof |
| CN109481536A (en) * | 2018-11-26 | 2019-03-19 | 广东新峰药业股份有限公司 | A kind of larynx disease spirit piece and preparation method thereof |
-
2009
- 2009-06-05 CN CNA2009100691511A patent/CN101564471A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102357159A (en) * | 2011-10-18 | 2012-02-22 | 刘天岐 | Bezoar anticancer pill |
| CN109106747A (en) * | 2018-07-02 | 2019-01-01 | 宁夏医科大学 | A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof |
| CN109481536A (en) * | 2018-11-26 | 2019-03-19 | 广东新峰药业股份有限公司 | A kind of larynx disease spirit piece and preparation method thereof |
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Open date: 20091028 |