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CN101553279A - Method and apparatus for light-based hair removal - Google Patents

Method and apparatus for light-based hair removal Download PDF

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Publication number
CN101553279A
CN101553279A CNA2007800108512A CN200780010851A CN101553279A CN 101553279 A CN101553279 A CN 101553279A CN A2007800108512 A CNA2007800108512 A CN A2007800108512A CN 200780010851 A CN200780010851 A CN 200780010851A CN 101553279 A CN101553279 A CN 101553279A
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average
pulse
light
pulses
maximum
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CN101553279B (en
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Z·卡尔尼
J·莱普塞尔特尔
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Alma Lasers Ltd
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Alma Lasers Ltd
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Priority claimed from PCT/IL2007/000274 external-priority patent/WO2007099545A2/en
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Abstract

Methods and apparatus for damaging hair follicles using a series of rapidly-delivered low-fluence pulses of coherent or incoherent light are disclosed herein. In some embodiments, the pulses of coherent or incoherent light have a wavelength or wavelengths primarily in the range between 750 nm and 1500 nm. In some embodiments, applied electromagnetic radiation comprising the rapidly-delivered low-fluence pulses is effective for concomitantly heating both the sub-dermal layer (i.e. the dermis) of the tissue and the hair follicles. In some embodiments, the thermal damaging of the hair follicles is useful for facilitating hair-removal.

Description

The method and apparatus of light depilation
Technical field
The method and apparatus that the present invention relates to use the light of laser for example and/or flash lamp to lose hair or feathers.
Background technology
The disclosure relates to (for example, being used for alopecia) the improved method and apparatus that uses laser and/or pulse incoherent light to destroy hair follicle.
Selective light pyrolysis effect (selective photothermolysis) is a kind of surgical method, in nineteen eighty-three (" Selective Photothermolysis:PreciseMicrosurgery by Selective Absorption of Pulsed Radiation " proposed by Anderson and Parrish, Science, Vol.220, pp.524-527), be used to destroy on the skin or near specific pathological changes of skin or ugly tissue, and health tissues is on every side caused minimum injury.Treat destructive tissue must have the electromagnetic radiation of some wavelength than around organize much bigger light absorption.This method comprises uses pulsed electromagnetic radiation to shine target and surrounding tissue, and this pulsed electromagnetic radiation can be absorbed by this target priority.Because the incident radiation that target absorbs is far above surrounding tissue, so the heating of surrounding tissue can be ignored usually.
In the past decade, many laser instrument and flash type equipment that remove unwanted hair based on selective light pyrolysis effect principle put goods on the market, and up to the present, this technology is extensive use clinically.During handling, with the skin in a branch of photo-irradiation treatment zone, contain melanic hair follicle and absorb the electromagnetic radiation of being transmitted, cause temperature to rise and hair follicle destruction.
Regrettably, according to this processing procedure, the light that is transferred to processing region has also heated patient simultaneously and has contained the abundant epidermis of neural melanin, therefore in many clinical settings, thinks that the depilation based on light is the process of a misery.
Having recognized at large at present needs a kind of improved method and apparatus that is used for hair treatment, it is heated to a sufficiently high temperature with hair follicle and comprises neural epidermis to destroy hair follicle and to make things convenient for alopecia simultaneously minimum heat energy to be transferred to, and this method and apparatus will be highly beneficial.This can be used for satisfying the long-term market demand to comfortable depilation.
The patent documentation of following discloses provides the background technology that may be correlated with, and its full content is introduced in this for your guidance: US application 2005/0215988; US 6,485, and 484; WO 2005/079687; US 6,544, and 259; US 5,632, and 741; US 5,752, and 948; US 6,214, and 034; US 6,273, and 884; US 5,683, and 380; US 6,514, and 243; US application 2005/0143792; US 5,735, and 844; US5,595,568; US application 2002/0019624; US application 2005/0143792.
Summary of the invention
The embodiments of the invention part is based on following wonderful discovery, promptly by (for example with the light pulse of a series of low energy densities (fluence), from the coherent optical pulse of laser instrument or from the incoherent light pulses of flash lamp) be transferred to the skin of processing region fast, can be at minimum degree ground heating epidermis when this processing region is removed hair.
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive method, described method comprises: the electromagnetic energy that a) will comprise a plurality of coherent optical pulses (for example is applied to described tissue regions, tissue surface), wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, be the maximum wavelength value that is at most 1500nm at the most, wherein:
I) the average pulse energy density of described a plurality of pulses is to be at least 3J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described minimum wavelength value is 780nm at least, and described maximum wavelength value is 1000nm at the most.
According to some embodiment, the average pulse persistent period of described pulse is 4 milliseconds at least.
According to some embodiment, the average pulse persistent period of described pulse is 10 milliseconds at least.
According to some embodiment, the average pulse persistent period of described pulse is 25 milliseconds at the most.
According to some embodiment, apply at least 5 pulses with described average repetitive rate.
According to some embodiment, apply at least 15 pulses with described average repetitive rate.
According to some embodiment, apply at least 30 pulses with described average repetitive rate.
According to some embodiment, every square centimeter average power density of the electromagnetic energy that is applied is to be at least 50 watts/cm at least 2The minimum average B configuration power density values.
According to some embodiment, described minimum average B configuration power density values is 75 watts/cm at least 2
According to some embodiment, described minimum average B configuration power density values is 100 watts/cm at least 2
According to some embodiment, described average power density is the minimum average B configuration power density values during time period when applying at least 5 pulses with described average repetitive rate at least.
According to some embodiment, described average power density is the minimum power density value during time period when applying at least 15 pulses with described average repetitive rate at least.
According to some embodiment, described average power density is the minimum power density value during time period when applying at least 30 pulses with described average repetitive rate at least.
According to some embodiment, described average power density is the minimum power density value that is at least during time period of 1 second at least.
According to some embodiment, described average power density is the minimum power density value that is at least during time period of 2 seconds at least.
According to some embodiment, described average power density is the minimum power density value that is at least during time period of 3 seconds at least.
According to some embodiment, the average power density of the electromagnetic energy that is applied is to be at most 250 watts/cm at the most 2The maximum power density value.
According to some embodiment, described maximum power density value is 150 watts/cm at the most 2
According to some embodiment, described average power density is the maximum power density value during time period of at least 1 second at the most.
According to some embodiment, described average power density is the maximum power density value during time period of at least 2 seconds at the most.
According to some embodiment, described average power density is the maximum power density value during time period of at least 3 seconds at the most.
According to some embodiment, the mean power of the electromagnetic energy that is applied is to be at least 50 watts minimum average B configuration performance number at least.
According to some embodiment, described minimum average B configuration performance number is 75 watts at least.
According to some embodiment, described minimum average B configuration performance number is 100 watts at least.
According to some embodiment, described mean power is the minimum average B configuration performance number during time period when applying at least 5 pulses with described average repetitive rate at least.
According to some embodiment, described mean power is the minimal power values during time period when applying at least 15 pulses with described average repetitive rate at least.
According to some embodiment, described mean power is the minimal power values during time period when applying at least 30 pulses with described average repetitive rate at least.
According to some embodiment, described mean power is the minimal power values that is at least during time period of 1 second at least.
According to some embodiment, described mean power is the minimal power values that is at least during time period of 2 seconds at least.
According to some embodiment, described mean power is the minimal power values that is at least during time period of 3 seconds at least.
According to some embodiment, the mean power of the electromagnetic energy that is applied is to be at most 250 watts maximum power value at the most.
According to some embodiment, described maximum power density value is 150 watts at the most.
According to some embodiment, described mean power is the maximum power value during time period of at least 1 second at the most.
According to some embodiment, described mean power is the maximum power value during time period of at least 2 seconds at the most.
According to some embodiment, described mean power is the maximum power value during time period of at least 3 seconds at the most.
According to some embodiment, described minimum repetition values is 7.5HZ at least.
According to some embodiment, the average repetitive rate of described a plurality of pulses is the maximum repetition values that is at most 20HZ at the most.
According to some embodiment, described maximum repetition values is 15HZ at the most.
According to some embodiment, described maximum mean energy density value is 15J/cm at the most 2
According to some embodiment, described maximum mean energy density value is 12.5J/cm at the most 2
According to some embodiment, described maximum mean energy density value is 10J/cm at the most 2
According to some embodiment, described minimum average B configuration energy density values is 5J/cm at least 2
According to some embodiment, described minimum average B configuration energy density values is 7.5J/cm at the most 2
According to some embodiment, the pulse energy density standard deviation of described a plurality of pulses is to be at most 0.5 standard deviation value with the ratio of the average pulse energy density of described a plurality of pulses at the most.
According to some embodiment, described standard deviation is 0.2 than at the most.
According to some embodiment, the electromagnetic energy that is applied is used for the subcutis of skin area is heated to the minimum temperature of at least 42 degree.
According to some embodiment, described minimum temperature is 45 degree at least.
According to some embodiment, the electromagnetic energy that is applied is used for the subcutis of skin area is heated to the maximum temperature of 50 degree at the most.
According to some embodiment, the ratio of the peak power of described coherent optical pulse and mean power is to be at least 1.5 minimum power ratio at least.
According to some embodiment, described minimum power is 2 than at least.
According to some embodiment, described minimum power is 5 than at least.
According to some embodiment, the peak power of described coherent optical pulse is to be at most 20 maximum power ratio with the ratio of mean power at the most.
According to some embodiment, described maximum power ratio is 15 at the most.
According to some embodiment, described maximum power ratio is 10 at the most.
According to some embodiment, the peak power of the electromagnetic energy that is applied is to be at most 1500 watts maximum peak power value at the most.
According to some embodiment, described maximum peak power value is 1000 watts at the most.
According to some embodiment, the facula area of described coherent light is at 0.5cm 2And 2cm 2Between.
According to some embodiment, described facula area surpasses 1.2cm 2
According to some embodiment, the average pulse energy density of described a plurality of pulses and the ratio of average repetitive rate are the (J * s)/cm that is at most 3 at the most 2Maximum ratio.
According to some embodiment, described maximum ratio is 2.5 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 2 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 1.5 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 1 at the most (J * s)/cm 2
According to some embodiment, described average pulse energy density is to be at most 1.5J/ (cm with the ratio of described average pulse persistent period at the most 2* ms) maximum ratio.
According to some embodiment, described maximum ratio is 1J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 0.75J/ (cm at the most 2* ms).
According to some embodiment, the size of described tissue regions is 2cm at least 2, be 1000cm at the most 2
According to some embodiment, the step that applies described coherent optical pulse comprises uses diode laser to produce described coherent light.
According to some embodiment, described electromagnetic energy transmits from applicator, and described applicator is positioned at described tissue regions top, and has the gap between the surface of the lower surface of described applicator and described tissue regions.
According to some embodiment, described electromagnetic energy transmits from applicator, and described applicator comprises: i) transparent transfer surface; And ii) spacer shell, described applicator is configured to when the surface engagement of applicator and tissue regions, and described transparent transfer surface is in the surface of described tissue regions.
According to some embodiment, use applicator with the minimum applicator that is to be at least the minimum applicator velocity amplitude of 1cm/sec at least and is the maximum applicator velocity amplitude that is at most 20cm/sec at the most, on the surface of described tissue regions, move at least to be at least 2cm apart from carrying out applying of the electromagnetic energy that comprises described a plurality of pulses.
According to some embodiment, described minimum applicator distance is 3cm at least.
According to some embodiment, described minimum applicator speed is 3.5cm/sec at least.
According to some embodiment, described maximum applicator speed is 10cm/sec at the most.
According to some embodiment, described maximum applicator speed is 6.5cm/sec at the most.
According to some embodiment, described method also comprises: b) at least a portion of the described tissue of cooling.
According to some embodiment, apply described electromagnetic energy and do not cool off described tissue regions.
According to some embodiment, described applying comprises: i) set up the energy stage, wherein surface area is 2cm 2The given area stand the electromagnetic energy that comprises described a plurality of pulses that applies with described average repetitive rate; And ii) at described energy after the stage, set up Remaining Stages for described given area immediately, the persistent period of described Remaining Stages be at least 2 seconds be the persistent period in maximum residual stage at the most, the described persistent period in maximum residual stage is 60 minutes at the most, thereby during described Remaining Stages, the wavelength that is applied to described tissue regions is 750nm at least, and the mean power that is the electromagnetic energy that is applied of 1500nm at the most is 30 watts at the most; Iii) after described Remaining Stages, to described given tissue regions repeating step (a) and (b) at least M time, M is that value is at least 1 integer immediately.
According to some embodiment, the described Remaining Stages persistent period is 10 seconds at least.
According to some embodiment, the described Remaining Stages persistent period is 30 seconds at least.
According to some embodiment, the described Remaining Stages persistent period is 90 seconds at least.
According to some embodiment, the described Remaining Stages persistent period is 10 minutes at the most.
According to some embodiment, the described Remaining Stages persistent period is 5 minutes at the most.
According to some embodiment, M is 2 at least.
According to some embodiment, M is 3 at least.
According to some embodiment, for each energy stage of a plurality of Remaining Stages, the energy density that applies for the accumulation of the electromagnetic energy that is applied in each energy stage is 20 joules/cm in time period of 20 minutes at the most at least 2, be 200 joules/cm at the most 2
According to some embodiment, the electromagnetic energy that will comprise described pulse is applied on the light skin.
According to some embodiment, the electromagnetic energy that will comprise described pulse is applied to the tissue that comprises low melanin hair, to destroy described low melanin hair.
According to some embodiment, the electromagnetic energy that will comprise described pulse is applied on the skin of Fitzpatrick Class1-3, to destroy the hair that is associated with Fitzpatrick Class1-3.
According to some embodiment, the electromagnetic energy that will comprise described pulse is applied on the skin of Fitzpatrick type 4-6, to destroy the hair that is associated with Fitzpatrick type 4-6.
According to some embodiment, described electromagnetic energy is applied to described tissue to destroy the low melanin hair that is associated with this tissue.
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of light pulses is applied to described tissue regions, and wherein each described light pulse comprises that mainly wave-length coverage is at the minimum wavelength value of 750nm at least and one or more wavelength between the maximum wavelength value of 1500nm at the most, wherein:
I) ratio of the average pulse energy density of described a plurality of light pulses and the repetitive rate of described a plurality of light pulses is the (J * s)/cm that is at most 3 at the most 2Maximum ratio; And
Ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described a plurality of light pulses comprise the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiment, described a plurality of light pulses comprise the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiment, at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, described maximum ratio is 2J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 1.5J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 1J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 0.75J/ (cm at the most 2* ms).
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive method, described method comprises: the electromagnetic energy that a) will comprise a plurality of light pulses is applied to described tissue regions, wherein each described light pulse comprises that mainly wave-length coverage is the minimum wavelength value of 750nm and is one or more wavelength between the maximum wavelength value of 1500nm at the most that wherein: i) the average pulse energy density of described a plurality of pulses is to be at most 1.5J/ (cm with the ratio of the average pulse persistent period of described pulse at the most at least 2* ms) maximum; And ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described a plurality of light pulses comprise the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiment, described a plurality of light pulses comprise the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiment, at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, described maximum ratio is 1J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 0.75J/ (cm at the most 2* ms).
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive method, described method comprises: the electromagnetic energy that a) will comprise a plurality of coherent optical pulses is applied to described tissue regions, wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, be the maximum wavelength value that is at most 1500nm at the most, wherein: i) the average pulse energy density of described a plurality of pulses is to be at least 5J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value; Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 7.5HZ at least; And iii) the average pulse persistent period of described light pulse is 7.5 milliseconds at least, is 25 milliseconds at the most; And iv) apply at least 15 described pulses with described average repetitive rate.
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive method, described method comprises: the electromagnetic energy that a) will comprise a plurality of coherent optical pulses is applied to described tissue regions, wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, be the maximum wavelength value that is at most 1500nm at the most, wherein: i) the average pulse energy density of described a plurality of pulses is to be at least 5J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value; Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 7.5HZ at least; And iii) the average pulse persistent period of described light pulse is 7.5 milliseconds at least, is 25 milliseconds at the most; Iv) the mean power of described a plurality of pulses is 60 watts at least; And v) apply at least 15 described pulses with described average repetitive rate.
Disclose first now and a kind of hair follicle in the tissue regions with a plurality of hair follicles has been carried out destructive device, described device comprises: a) coherent source, be used to produce the coherent light that comprises a plurality of coherent optical pulses, the wavelength of wherein said coherent optical pulse is the minimum wavelength value that is at least 750nm at least, is the maximum wavelength value that is at most 1500nm at the most; And b) controller is used for controlling at least in part the pulse characteristic of described light pulse, and described source and described controller are configured so that: i) the average pulse energy density of described a plurality of pulses is to be at least 3J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value; Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described minimum wavelength value is 780nm at least, and described maximum wavelength value is 1000nm at the most.
According to some embodiment, described source and described controller are configured so that the average pulse persistent period of described pulse is 4 milliseconds at least.
According to some embodiment, described source and described controller are configured so that the average pulse persistent period of described pulse is 10 milliseconds at least.
According to some embodiment, described source and described controller are configured so that the average pulse persistent period of described pulse is 25 milliseconds at the most.
According to some embodiment, described source and described controller are configured to provide at least 5 pulses with described average repetitive rate.
According to some embodiment, described source and described controller are configured to provide at least 15 pulses with described average repetitive rate.
According to some embodiment, described source and described controller are configured to provide at least 30 pulses with described average repetitive rate.
According to some embodiment, described source and described controller are configured to provide the described coherent light that comprises described a plurality of pulses with every square centimeter of average power density, and described every square centimeter of average power density is to be at least 50 watts/cm at least 2The minimum average B configuration power density values.
According to some embodiment, described minimum average B configuration power density values is 75 watts/cm at least 2
According to some embodiment, described minimum average B configuration power density values is 100 watts/cm at least 2
According to some embodiment, it is described every square centimeter of average power density of minimum average B configuration power density values at least that described source and described controller are configured to provide when producing at least 5 pulses with described average repetitive rate.
According to some embodiment, it is described every square centimeter of average power density of minimum average B configuration power density values at least that described source and described controller are configured to provide when producing at least 15 pulses with described average repetitive rate.
According to some embodiment, it is described every square centimeter of average power density of minimum average B configuration power density values at least that described source and described controller are configured to provide when producing at least 30 pulses with described average repetitive rate.
According to some embodiment, described source and described controller are configured to the every square centimeter of average power density that is provided was kept 1 second at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to the every square centimeter of average power density that is provided was kept 2 seconds at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to the every square centimeter of average power density that is provided was kept 3 seconds at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to provide the described coherent light that comprises described a plurality of pulses with every square centimeter of average power density, and described every square centimeter of average power density is to be at most 250 watts/cm at the most 2The maximum average power density value.
According to some embodiment, described maximum power density value is 150 watts/cm at the most 2
According to some embodiment, described source and described controller are configured to the transmission of described every square centimeter of average power density was kept 1 second at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to the transmission of described every square centimeter of average power density was kept 2 seconds at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to the transmission of described every square centimeter of average power density was kept 3 seconds at least, and described every square centimeter of average power density is described minimum average B configuration power density values at least.
According to some embodiment, described source and described controller are configured to being that the mean power that is at least 50 watts minimum average B configuration performance number is operated at least.
According to some embodiment, described minimum average B configuration performance number is 75 watts at least.
According to some embodiment, described minimum average B configuration performance number is 100 watts at least.
According to some embodiment, described source and described controller are configured to operate with described mean power, and described mean power is the minimum average B configuration performance number during time period when applying at least 5 pulses with described average repetitive rate at least.
According to some embodiment, described source and described controller are configured to operate with described mean power, and described mean power is the minimum average B configuration performance number during time period when applying at least 15 pulses with described average repetitive rate at least.
According to some embodiment, described source and described controller are configured to operate with described mean power, and described mean power is the minimum average B configuration performance number during time period when applying at least 30 pulses with described average repetitive rate at least.
According to some embodiment, described source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 1 second at least.
According to some embodiment, described source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 2 seconds at least.
According to some embodiment, described source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 3 seconds at least.
According to some embodiment, described source and described controller are configured to being that the mean power that is at least 250 watts maximum average power value is operated at the most.
According to some embodiment, described maximum power density value is 150 watts at the most.
According to some embodiment, described source and described controller are configured to the described mean power that is at most described maximum average power value was kept 1 second at least.
According to some embodiment, described source and described controller are configured to the described mean power that is at most described maximum average power value was kept 2 seconds at least.
According to some embodiment, described source and described controller are configured to the described mean power that is at most described maximum average power value was kept 3 seconds at least.
According to some embodiment, described source and described controller are configured so that described minimum repetition values is 7.5HZ at least.
According to some embodiment, described source and described controller are configured so that the average repetitive rate of described a plurality of pulses is the maximum repetition values that is at most 20HZ at the most.
According to some embodiment, described source and described controller are configured so that described maximum repetition values is 15HZ at the most.
According to some embodiment, described source and described controller are configured so that described maximum mean energy density value is 15J/cm at the most 2
According to some embodiment, described source and described controller are configured so that described maximum mean energy density value is 12.5J/cm at the most 2
According to some embodiment, described source and described controller are configured so that described maximum mean energy density value is 10J/cm at the most 2
According to some embodiment, described source and described controller are configured so that described minimum average B configuration energy density values is 5J/cm at least 2
According to some embodiment, described source and described controller are configured so that described minimum average B configuration energy density values is 7.5J/cm at the most 2
According to some embodiment, the pulse energy density standard deviation that described source and described controller are configured so that described a plurality of pulses is to be at most 0.5 standard deviation ratio with the ratio of the described average pulse energy density of described a plurality of pulses at the most.
According to some embodiment, described standard deviation is 0.2 than at the most.
According to some embodiment, described source and described controller are configured to described coherent light is provided so that the coherent light that is provided is used for the subcutis of skin area is heated to the minimum temperature of at least 42 degree.
According to some embodiment, described minimum temperature is 45 degree at least.
According to some embodiment, described source and described controller are configured to described coherent light is provided so that the coherent light that is provided is used for the subcutis of skin area is heated to the maximum temperature of 50 degree at the most.
According to some embodiment, the ratio of peak power and mean power that described source and described controller are configured so that to comprise the described coherent light of described coherent optical pulse is to be at least 1.5 minimum power ratio at least.
According to some embodiment, described minimum power is 2 than at least.
According to some embodiment, described minimum power is 5 than at least.
According to some embodiment, the ratio of peak power and mean power that described source and described controller are configured so that to comprise the described coherent light of described coherent optical pulse is to be at most 20 maximum power ratio at the most.
According to some embodiment, described maximum power ratio is 15 at the most.
According to some embodiment, described maximum power ratio is 10 at the most.
According to some embodiment, described source and described controller are configured to provide the peak power of described coherent optical pulse, and described peak power is to be at most 1500 watts maximum peak power value at the most.
According to some embodiment, described maximum peak power value is 1000 watts at the most.
According to some embodiment, described device is used to provide facula area at 0.5cm 2And 2cm 2Between coherent light.
According to some embodiment, described facula area surpasses 1.2cm 2
According to some embodiment, the average pulse energy density that described source and described controller are configured so that described a plurality of pulses and the ratio of average repetitive rate are the (J * s)/cm that is at most 3 at the most 2Maximum ratio.
According to some embodiment, described maximum ratio is 2.5 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 2 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 1.5 at the most (J * s)/cm 2
According to some embodiment, described maximum ratio is 1 at the most (J * s)/cm 2
According to some embodiment, described source and described controller are configured so that described average pulse energy density and the ratio of described average pulse persistent period are to be at most 1.5J/ (cm at the most 2* ms) maximum ratio.
According to some embodiment, described maximum ratio is 1J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 0.75J/ (cm at the most 2* ms).
According to some embodiment, described maximum ratio is 0.6J/ (cm at the most 2* ms).
According to some embodiment, the step that applies described coherent optical pulse comprises uses diode laser to produce described coherent optical pulse.
According to some embodiment, described coherent source comprises diode laser.
According to some embodiment, described device also comprises: d) cooling package is used at least a portion of cools tissue.
According to some embodiment, described cooling package is selected from the group that is made of contact cooling package and spray cooling assembly.
According to some embodiment, described device also comprises: c) optical module, the described coherent light that is used for comprising described coherent optical pulse points to tissue regions.
According to some embodiment, described optical module comprises that light transmitting surface, surface area with substantially flat are at least 0.8cm 2The light transmission component of substantially transparent.
According to some embodiment, described device also comprises d) the applicator shell, be used to hold the light transmitting surface of described substantially flat, described applicator is configured so that when the surface engagement of applicator and tissue regions, and described transparent transfer surface is in the surface of tissue regions.
Now disclose a kind of device that is used for removing from the tissue regions with a plurality of hair follicles hair first, described device comprises:
A) coherent source is used to produce the coherent light that comprises a plurality of coherent optical pulses, and the wavelength of wherein said coherent optical pulse is the minimum wavelength value that is at least 750nm at least, is the maximum wavelength value that is at most 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and described source and described controller are configured so that:
I) the average pulse energy density of described a plurality of pulses is to be at least 0.5J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
Now disclose a kind of device that is used for removing from the tissue regions with a plurality of hair follicles hair first, described device comprises:
A) light source is used to produce the light that comprises a plurality of light pulses, and each described light pulse comprises that mainly wave-length coverage is being the minimum wavelength value of 750nm at least and is being one or more wavelength between the maximum wavelength value of 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and wherein said source and described controller are configured so that:
I) ratio of the average pulse energy density of described a plurality of light pulses and the repetitive rate of described a plurality of light pulses is the (J * s)/cm that is at most 3 at the most 2Maximum ratio; And
Ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described light source comprises and is configured so that described a plurality of light pulse comprises the coherent source of the coherent optical pulse of wavelength in described wave-length coverage.
According to some embodiment, described light source comprises and is configured so that described a plurality of light pulse comprises the incoherent light source of the incoherent light pulses of wavelength in described wave-length coverage.
According to some embodiment, described incoherent light source is configured so that at least 75% relevant light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, described incoherent light source is configured so that at least 95% relevant light wavelength of described incoherent light pulses is in described scope.
According to some embodiment, described maximum ratio is 2J/ (cm at the most 2* ms).
According to some embodiment, described controller and described light source are configured so that described maximum ratio is 1.5J/ (cm at the most 2* ms).
According to some embodiment, described controller and described light source are configured so that described maximum ratio is 1J/ (cm at the most 2* ms).
According to some embodiment, described controller and described light source are configured so that described maximum ratio is 0.75J/ (cm at the most 2* ms).
A kind of device that is used for removing from the tissue regions with a plurality of hair follicles hair is disclosed now first, described device comprises: a) light source, be used to produce the light that comprises a plurality of coherent optical pulses, the wavelength of described coherent optical pulse is the minimum wavelength value that is at least 750nm at least, is the maximum wavelength value that is at most 1500nm at the most; And b) controller, be used for controlling at least in part the pulse characteristic of described light pulse, wherein said source and described controller are configured so that: i) the average pulse energy density of described a plurality of pulses is to be at most 1.5J/ (cm with the ratio of the average pulse persistent period of described pulse at the most 2* ms) maximum; And the average pulse persistent period of ii) described light radiation pulse is 1 millisecond at least.
Disclosing now a kind of being used for first carries out destructive method to the hair follicle of tissue regions with a plurality of hair follicles, described method comprises: the electromagnetic energy that a) will comprise a plurality of light pulses is applied to skin area, be heated to first temperature and the epidermis of skin area be not heated to that to surpass be 42 degrees centigrade second temperature at the most with subcutis skin area, described first temperature is 42 degrees centigrade at least and is lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and hair follicle is heated so that hair is removed, ii) the average repetitive rate of pulse is 5 pulse/sec at least.
According to some embodiment, average repetitive rate is 7.5 pulse/sec at least.
According to some embodiment, light pulse is a coherent optical pulse.
According to some embodiment, first temperature is 45 degree at least.
Disclosing now a kind of being used for first carries out destructive method to the hair follicle of tissue regions with a plurality of hair follicles, described method comprises: the electromagnetic energy that a) will comprise a plurality of light pulses is applied to skin area, be heated to first temperature and the epidermis of skin area be not heated to that to surpass be 42 degrees centigrade second temperature at the most with subcutis skin area, described first temperature is 42 degrees centigrade at least and is lower than 50 degrees centigrade, wherein: i) apply light pulse and hair follicle is heated so that hair is removed, ii) the average repetitive rate of pulse is 5 pulse/sec at least.
According to some embodiment, first temperature is 45 degree at least.
Disclosing now a kind of being used for first carries out destructive method to the hair follicle of tissue regions with a plurality of hair follicles, described method comprises: a) apply the electromagnetic energy at least 0.5 second that comprises a plurality of light pulses and time period of 20 seconds at the most to skin area, be heated to first temperature with subcutis with skin area, to surpass be 42 degrees centigrade second temperature at the most and the epidermis of skin area is not heated to, described first temperature is 42 degrees centigrade and is lower than 50 degrees centigrade that wherein the mean power of the electromagnetic radiation during this time period equals to be at most 250 watts maximum average power value at the most at least.
According to some embodiment, first temperature is 45 degree at least.
According to some embodiment, the persistent period of described time period is 1.5 seconds at least.
According to some embodiment, the persistent period of described time period is 3 seconds at least.
According to some embodiment, the persistent period of described time period is 5 seconds at least.
According to some embodiment, the persistent period of described time period is 10 seconds at least.
Disclosing now a kind of being used for first carries out destructive method to the hair follicle of tissue regions with a plurality of hair follicles, described method comprises: a) apply the electromagnetic energy at least 0.5 second that comprises a plurality of light pulses and time period of 20 seconds at the most to skin area, be heated to first temperature with subcutis with skin area, to surpass be 42 degrees centigrade second temperature at the most and the epidermis of skin area is not heated to, described first temperature is 42 degrees centigrade at least and is lower than 50 degrees centigrade, and wherein the ratio of the peak power of the electromagnetic energy during this time period and mean power is to be at least 1.5 power ratio at least.
According to some embodiment, first temperature is 45 degree at least.
According to some embodiment, power ratio is 2. at least
A kind of method that is used for removing from the skin area with a plurality of hair follicles low melanin hair is disclosed now first, each hair follicle all extends in the skin, described method comprises: a) apply a plurality of light pulses to skin area, be heated to first temperature with subcutis with skin area, to surpass be 42 degrees centigrade second temperature at the most and the epidermis of skin area is not heated to, described first temperature is 45 degrees centigrade at least and is lower than the heat damage temperature of hair follicle, wherein: i) apply that light pulse is heated hair follicle so that low melanin (promptly, gold and/or red and/or gray) hair is removed, and ii) the mean energy density of pulse is 20J/cm at the most 2
In the exemplary embodiment, pulse is a coherent optical pulse, and the mean energy density of coherent optical pulse is 20J/cm at the most 2Now disclose a kind of method of removing hair from the skin area with a plurality of hair follicles first, each hair follicle extends in the skin.Current disclosed method comprises: a) apply a plurality of light pulses to skin area, be heated to first temperature with subcutis with skin area, to surpass be 42 degrees centigrade second temperature at the most and the epidermis of skin area is not heated to, described first temperature is 45 degrees centigrade at least and is lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and hair follicle is heated so that hair is removed, ii) the average repetitive rate of pulse is 5 pulse/sec at least.
In the exemplary embodiment, average repetitive rate is 7.5 pulse/sec at least.
In the exemplary embodiment, light pulse is a coherent optical pulse.
Now disclose a kind of method of removing hair from the skin area with a plurality of hair follicles first, each hair follicle extends in the skin.Current disclosed method comprises: a) apply a plurality of light pulses to skin area, be heated to first temperature with subcutis with skin area, to surpass be 42 degrees centigrade second temperature at the most and the epidermis of skin area is not heated to, described first temperature is 45 degrees centigrade at least and is lower than the heat damage temperature of hair follicle, wherein: i) apply light pulse and hair follicle is heated so that hair is removed, ii) the peak power of light pulse is 1.5 with the ratio of mean power at least.
A kind of device of removing hair from the skin area with a plurality of hair follicles is disclosed now first.Described device comprises: a) impulse radiation source is used to produce a plurality of coherent optical pulses; B) optical module (for example, comprise waveguide), it for example is embedded in applicator or the bonder, the light pulse that is used for being produced is pointed to tissue regions (promptly, via tissue surface), and c) controller is used for determining the pulse characteristic of light pulse, so that i) the average pulse energy density of described a plurality of pulses is to be at least 0.5J/cm at least 2The minimum energy density value, be to be at most 20J/cm at the most 2The maximum energy-density value; Ii) the average repetitive rate of described a plurality of pulses is the repetition values of 5HZ at least; And iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
According to some embodiment, described device also comprises: d) cooling package is used to cool off tissue surface at least.
Notice that some embodiment provide and have been used to carry out arbitrarily that the device of current described depilating method (for example, comprises laser instrument and/or flash lamp; For example, comprise computer control) with electronic circuit and/or software.In the exemplary embodiment, will install to be programmed in advance and carry out any processing scheme as described herein (that is, describing energy density and/or the pulse duration and/or the power parameter of repetitive rate and/or light pulse).
Note, described a plurality of processing schemes here.Be appreciated that the configuration carry out current disclosed processing scheme any apparatus or the device all within the scope of the invention.
From following detailed and example, these and further embodiment will be clearer.
Description of drawings
Figure 1A illustrates the block diagram of the exemplary means of use electromagnetic radiation destruction hair follicle according to some embodiments of the invention to Fig. 1 C;
Fig. 2 illustrates the block diagram of exemplary control unit;
Fig. 3 illustrates the block diagram of exemplary pulse light source;
Fig. 4 illustrates the block diagram as the energy intensity of the function of time at the exemplary process scheme;
Fig. 5 A illustrates the block diagram in exemplary process zone;
Fig. 5 B illustrates the block diagram of the example technique of each sub regions that is used to handle a processing region;
Fig. 6 illustrates the flow chart that is used to handle such as the example process in the given position of the tissue of skin or zone.
Though described the present invention, it will be recognized by those skilled in the art that the present invention is not limited to described embodiment or accompanying drawing by some embodiment and illustrative embodiments at this.Be construed as, accompanying drawing and detailed description are not intended to limit the invention and are particular forms disclosed, but opposite, this invention is intended to cover all modifications in the principle of the invention and the scope, be equal to and replace.As employed in the whole text among the application, word " can " have the connotation of allowing (that is, meaning " possible "), and optional connotation (that is, meaning " necessary ").
The specific embodiment
Now present invention is described at concrete exemplary embodiment.Be appreciated that the present invention is not limited to disclosed exemplary embodiment.Be also to be understood that the current disclosed apparatus and method that are used for the heat damage hair follicle, not all feature all is necessary for desired invention of claim of any specific of implementing claims.Various elements and the feature of having described device realize the present invention fully.Be also to be understood that in whole the disclosing of a process of describing or illustrating or method, the step of method can be carried out or carry out simultaneously with random order, depend on the step that another is formerly carried out unless clearly illustrate that a step from context.
General introduction and theoretic discussion
The embodiments of the invention part is based on following wonderful discovery, promptly by (for example with the light pulse of a series of or a plurality of low energy densities, from the coherent optical pulse of laser instrument or from the incoherent light pulses of flash lamp) be transferred to the skin of processing region fast, can destroy the hair follicle minimum degree ground heating epidermis simultaneously in this processing region effectively.Note that the foreshortened follicle destroy technology can be used for removing hair easily from the skin safe of processing region.
Particularly, and do not want bound by theory ground, please note, even each independent low energy densities pulse only provides the peak power of " low " relatively, but a plurality of low energy densities pulse collections of transmission get up also to transmit the mean power of " height " relatively on time enough fast, thereby heat conducting subcutis or corium are heated to enough temperature (for example, at least 42 degree or at least 45 degree), thereby hair follicle is corrupted to the degree that makes things convenient for alopecia.
Do not want bound by theory ground once more, suppose: because corium is good heat conductor, so when pulse with " high-repetition-rate " when transmitting fast, (i) temperature of hair follicle in a time period of enough destroying hair follicle, can not be reduced to the corium that has heated temperature (promptly, the dermal temperature that has heated) under, (ii) hair follicle this adds heat damage and can be used for making things convenient for alopecia.
Note, can use the light of particular range of wavelengths to heat and destroy hair follicle (that is, can be used for the mode of hair).Therefore, in certain embodiments, fast the low energy densities pulsed-light radiation of transmission comprises wavelength light in " optical window " of (or between 780nm and 1000nm) between 750nm and 1500nm, it is penetrated under the epidermis, and the subepidermal tissue layer under epidermis (that is corium) transmission of power.
Bound by theory ground is not noted, the light in this " optical window " than 650nm for example in the scope between the 700nm or the light in other scope to lack the heating of epidermis.Therefore, the chromophore in the surrounding tissue (chromophore) can be heated effectively and destroys hair follicle as " reservoir (reservoir) ", rather than rely on selective light pyrolysis effect fully and heat the hair follicle that melanin enriches.
In certain embodiments, for the coherent light of concrete condition, can provide one or more following features:
Total average power density of the i) light radiation of being transmitted (for example, coherent light) is at least 35 watts/cm 2, or at least 50 watts/cm 2, or at least 75 watts/cm 2Should " high-average power " (for example can continue sufficiently long " exposure " time, at least 0.5 second, or longer, such as at least 1 second or at least 2 seconds or longer) the subepidermal tissue (or corium) in the given hair follicle zone is heated at least 42 or at least 45 degree;
Ii) the ratio between the peak power of coherent light and the aforementioned mean power is at most 20 or was at most 10 (for using situation about handling such as the coherent light of laser).This can be avoided hair carbonization and/or the superheated situation of epidermis;
Iii) " fast-pulse ", (for example, coherent optical pulse) repetitive rate is at least 3.5 pulse/sec, or at least 5 pulse/sec, or 7.5 pulse/sec at least and at the most in wherein light pulse;
The mean energy density (that is, average in each pulse) of iv) fast a plurality of light pulses of transmission (for example, relevant or incoherent light pulses) is 3J/cm at least 2(or 5J/cm at least 2) and 20J/cm at the most 2(or 15J/cm at the most 2); And
V) a plurality of light pulses (promptly, " short pulse ") in each pulse (for example, relevant or noncoherent) average pulse persistent period or " pulse width " be at least 3 milliseconds and 25 milliseconds at the most for the situation of coherent light, for example between 10 milliseconds and 20 milliseconds.For the situation of incoherent light, can provide different pulse width (for example, shorter pulse width).
For the situation of incoherent light, different feature and values can be provided, though in the exemplary embodiment, can get incoherent light pulses with the repetitive rate transmission of relative " fast " a series of " low energy densities " relatively.
The instruction that the embodiment of the invention provides can be applied to coherent light equipment and scheme (for example, using the laser instrument that includes but not limited to diode laser) and incoherent light equipment and scheme (for example, using the broadband light of filtering).
Notice that instruction of the present invention can be used for removing hair from any zone of health, includes but not limited to back, face, head, eyebrow, eyelashes, chest, abdominal part, genital area, lower limb and axillary fossa.
In addition, note, apply or transmit light, for example one or more light pulses to the given area of tissue (for example skin) or subregion or zone, refer to light (for example, one or more light pulses) is applied or be transferred to this zone of tissue or the optional position in the subregion.
Light radiation and pulse characteristic
Various embodiment of the present invention provides the combination in any of following marked feature.Be appreciated that not to be that in following these features each all must be included among each embodiment.
A) wavelength characteristicThe invention discloses processing method and device to patient's skin transmission light radiation, described light radiation comprises " degree of depth penetrates " light radiation, and it passes the abundant epidermis of melanin and is absorbed by subepidermal tissue (that is corium).In certain embodiments, the light radiation that this degree of depth penetrates comprises the light of wavelength between minimum wavelength value (for example 750nm, for example 780nm or 800nm) and maximum wavelength value (for example 950nm, or 980nm, or 1000nm, or 1200nm, or 1500nm).Bound by theory ground not, disclose: select the light in " optical window " can be used to provide unlikely heating to contain the processing scheme (or treatment facility) of neural epidermis, thereby getting rid of (but nonessential elimination) loaded down with trivial details cooling (follow to apply, or use " pre-cooled scheme " apply) needs and/or safer processing scheme is provided.
In the exemplary embodiment relevant with the organized processing of utilizing laser, for example provide above-mentioned wavelength characteristic by the semiconductor diode laser that uses wavelength to be approximately 810nm, other laser equipment is also within the scope of the invention certainly.
In the exemplary embodiment relevant with incoherent light, by providing light (for example with a plurality of frequencies, light from the IPL equipment that utilizes band-pass filter) provide above-mentioned wavelength characteristic, make the most wavelength of the light radiation applied at minimum wavelength value (750nm for example, for example 780nm or 800nm) and maximum wavelength value (for example 950nm, or 980nm, or 1000nm, or 1200nm, or 1500nm) in the defined setted wavelength scope.
In certain embodiments, the incoherent light that is applied and/or its each pulse " mainly " comprise by the wavelength in minimum wavelength value and the defined scope of maximum wavelength value---promptly, at least 70% the incoherent light or the wavelength of its each pulse are in this scope.
In certain embodiments, the wavelength of at least 75% incoherent light or its each pulse is in this scope.
In certain embodiments, the wavelength of at least 90% incoherent light or its each pulse is in this scope.
In certain embodiments, the wavelength of at least 95% incoherent light or its each pulse is in this scope.
B) energy density featureThe present invention discloses first: can apply the low energy densities pulse by the skin to patient and remove hair.The particular energy density value can incoherent light be applied to tissue and destroys hair follicle and difference according to laser still being.
In the exemplary embodiment of the light radiation that is applied from laser instrument, " low energy densities " average pulse is 20J/cm at the most 2Every pulse, or 15J/cm at the most 2Every pulse, or 12.5J/cm at the most 2Every pulse, or 10J/cm at the most 2Every pulse.In the exemplary embodiment of the light radiation that is applied from laser instrument, " low energy densities " pulse is 0.5J/cm at least 2, or 3J/cm at least 2, or 5J/cm at least 2
Being appreciated that when having applied a plurality of series of pulses, is not that each independent pulse all must have just in time identical energy density, and the energy density between the different pulses can change.
Yet, in certain embodiments, given a plurality of (for example, at least 3 or at least 5 or at least 15 or at least 30) each pulse in the pulse has the energy density in disclosed " average pulse energy density " scope, for example, for the situation of coherent light or laser, the energy density of each pulse in given a plurality of pulses is less than 20J/cm 2, or less than 15J/cm 2, or less than 12.5J/cm 2In the example relevant with incoherent light (for example, from flash lamp), the energy density of each pulse in this series or a plurality of pulse is less than 10J/cm 2Or 8J/cm 2Deng.
Notice that the concrete energy density that is provided (and such as pulse width, repetitive rate, power etc. other features) can be depending on a plurality of physiologic factors, includes but not limited to skin color and hair color.For example, for the hair (the not too hair of " deceiving ") of light color, need to select bigger energy density.Similarly, for darker skin, need to select littler energy density.
Notice that these low energy densities pulses are very effective for depilation.
C) repetitive rate featureThe present invention discloses first with certain " height " repetitive rate light has been applied to depilation scheme and equipment on the skin.
As used herein, " repetitive rate " is illustrated in the ratio (that is being unit with pulse per second or HZ) of the independent pulse of being transmitted in the preset time section--and the pulse number that transmits or provide is divided by the length of " given " time period.In different embodiment, preset time, section for example can be at least 0.5 second, at least 1 second, at least 1.5 seconds, at least 2 seconds, at least 3 seconds, at least 5 seconds or at least 10 seconds.
In the exemplary embodiment of the light radiation that is applied from laser instrument, repetitive rate is at least 5 pulse/sec, and/or at least 7.5 pulse/sec, and/or at least 10 pulse/sec.In the exemplary embodiment of the light radiation that is applied from laser instrument, repetitive rate is 25 pulse/sec at the most, and/or 20 pulse/sec at the most, and/or 15 pulse/sec at the most.
D) pulse duration/the pulse width featureThe light radiation that is applied be coherent light (for example, from laser instrument such as diode laser) exemplary embodiment in, pulse duration (that is the persistent period of individual pulse) is at least 3 milliseconds and/or at least 5 milliseconds and/or at least 10 milliseconds and/or at least 15 milliseconds.In the exemplary embodiment of the light radiation that is applied from laser instrument, the pulse duration is 30 milliseconds and/or 25 milliseconds and/or 20 milliseconds at the most at the most at the most.
Notice that concrete energy density that is provided and concrete pulse duration or pulse width can be depending on a plurality of physiologic factors, include but not limited to skin color and hair color.For example, for the hair (the not too hair of " deceiving ") of light color, need select to have long pulse than macro-energy density.Similarly, for darker skin, need to select to have the short pulse of less energy density.
E) relation between energy density and pulse duration and/or the peak powerIn the exemplary embodiment, the pulse of low energy densities can be the pulse of " wide, flat " relatively that applies with maximum peak power on the minimum time section.In an example relevant with laser pulse, transmission of power density is at least 10J/cm at least 22 milliseconds time period 2Pulse.Therefore, in the exemplary embodiment relevant with laser pulse, the ratio in energy density and pulse duration is 1.5J/ (cm at the most 2* ms), and/or 1J/ (cm at the most 2* ms), and/or 0.7J/ (cm at the most 2* ms) M, and/or 0.5J/ (cm at the most 2* ms).
F) relation between energy density and the repetitive rateIn the exemplary embodiment, applied " the serial low energy densities pulse that applies fast " light.Therefore, in the exemplary embodiment, the ratio between the average pulse energy density of a plurality of light pulses and the repetitive rate of a plurality of light pulses is (J * s)/cm at the most for 3 2, or at the most 2 (J * s)/cm 2, or at the most 1.5 (J * s)/cm 2Maximum rate.
G) mean power feature.
In certain embodiments, in order to ensure subcutis (that is corium) (or its part) is heated to above minimum corium heating-up temperature and minimum average B configuration power (that is, with minimum average B configuration power delivery incoherent light and/or coherent light) is provided.For example, provide 35 watts/cm in section preset time (that is, corium being heated at least 42 or 45 degrees centigrade of required enough times) 2Or 50 watts/cm 2The minimum average B configuration power density.
Bound by theory ground not, note, by (for example with relative " high " mean power operation section preset time, at least 0.5 second, or at least 1 second, or at least 2 seconds etc.-or transmit certain minimal amount pulse the time period-for example, at least 3,5,10,15 or 30 pulses), can provide enough power to heat subcutis or corium.
In certain embodiments, for example processing for safer processing being provided and/or not too needing to cool off corium provides maximum average power (and/or maximum average power of some wavelength light).Therefore, in the exemplary embodiment, mean power is less than 400 watts or less than 300 watts or less than 200 watts or less than 150 watts.
H) the ratio feature of peak power and mean powerThe invention discloses processing and the equipment of the time dependent light radiation of intensity transmission with heating patient's subepidermal tissue (that is corium).In certain embodiments, apply and have the light radiation of the suitable wavelength of the intensity of change profile in time, ratio maximum between radiating peak power that is wherein applied and the radiating mean power that is applied is first ratio, and alternatively, is second ratio at least.First ratio that provides by different embodiment and the example of second ratio below are provided.
Bound by theory ground not, note, for the situation of ratio greater than second ratio, the light radiation that is applied is characterized in that the strong pulse with the weak point of low frequency transmission, even for the wavelength in " optical window ", this also may be unnecessarily (because the suffered intensive energy burst of skin) epidermis heating (especially, but being not limited to the darker patient of skin) is surpassed required degree, thereby need stronger cooling that safe epilation process is provided.Therefore, by avoiding these strong pulses (promptly, by avoiding causing the ratio between peak power and the mean power to surpass the strong pulse of specifying ratio), in the exemplary embodiment, a kind of unlikely removal can be provided or burn epidermis and/or the processing of hair shaft.
Therefore, (for example, the light radiation that is applied is from the coherent source of the diode laser that includes but not limited to wavelength 810nm) in certain embodiments, this second proportionality in this way at the most 20 or at the most 15 or at the most 12 or at the most 10.
In addition, note, when the ratio between peak power and the mean power near 1 the time, this equipment becomes CW equipment rather than the radiating equipment of transmission pulse.In the exemplary embodiment, in fact current disclosed equipment provide the time dependent radiation of intensity-this at least a portion that for example helps the energy that will be transmitted to be positioned hair follicle.
Therefore, (for example, the light radiation that is applied is from the coherent source of the diode laser that includes but not limited to wavelength 810nm) in certain embodiments, this first proportionality in this way at least 1.2, at least 1.5, at least 2 and/or at least 3.Notice that making first ratio surpass 1 is the marked feature of pulse energy equipment, this is opposite with special-purpose CW equipment, and this ratio is 1 in the special-purpose CW equipment.
In different embodiment, at least 30% or at least 50% or at least 70% or at least 90% conduct of the electromagnetic energy that is transmitted (electromagnetic energy in one or more designated wavelength range described herein that is perhaps transmitted) is concerned with and/or incoherent light pulses provides.
According to some embodiment, the ratio of the peak power of the coherent optical pulse that is applied and mean power is 1.5 power ratio (for example, at least 1.5, at least 2.5, at least 5) at least.
According to some embodiment, the ratio of the peak power of the coherent optical pulse that is applied and mean power is 20 power ratio (for example, at the most 15 or at the most 12) at the most.
Exemplary process equipment
Figure 1A illustrates block diagram according to the exemplary apparatus of exemplary embodiment of the present invention to Fig. 1 C.These figure (and all figure) are illustrative and nonrestrictive.
This equipment comprises light-pulse generator 110 (such as the incoherent light source of flash lamp and/or such as the coherent source of laser instrument), controller 215 (in the instantiation of this figure, providing the part as control unit 116) and applicator 114.
Applicator 114 is suitable for the processing region transmission light to patient.In certain embodiments, applicator 114 comprises a shell with aperture, and this aperture is used to transmit light pulse.In certain embodiments, can provide control to determine or control applicator size.
Notice that being used for to skin transmission light radiation is known in the field with the applicator 114 of removing hair, and any known applicator 114 and any known applicator feature may be used to the current disclosed device that is used for losing hair or feathers.
In certain embodiments, applicator can comprise the embedded Control of some types and/or can combine with the embedded Control of some types, and these control examples are as for being used to control the radiation transmitted-for example, the button of " ON/OFF " control.
Although applicator 114 is shown as and contact skin (that is, contacting with epidermis 52) in Figure 1A, can not think that this is a restriction, do not contact skin and embodiment that light is applied on the skin falls within the scope of the present invention.
In Figure 1B, applicator 114 skin surface " on " (that is, not contacting skin), make that having length between the bottom of applicator 114 and the skin surface is the gap of d1.
In Fig. 1 C, applicator 114 comprises transparent energy transmission 45, and relevant and/or incoherent light (and other electromagnetic energy) alternatively is applied to skin surface 49 by this element.Energy transmission 45 is configured in the applicator 114, is d2 " at interval " or " gap " so that have length hanging down of transparent energy transmission 45 between surface (or energy transfer surface 43) and the skin surface.
Arrive as shown in Fig. 1 C as Figure 1A, control unit 116 (for example comprises controller 215, (i) for example comprise microprocessor and/or use the automatic electronic controller of the code that combination in any provided of software and hardware, and/or manual controller), the various parameters that are used for the electromagnetic radiation that control impuls light source 110 launched.
Therefore, notice that in the instantiation of Fig. 1 C and Fig. 2, controller 215 is provided with (and being arranged in independent unit) separately with light source 110 and applicator 114 at Figure 1A.This can not think a restriction.In certain embodiments, " controller " 215 can be configured to the integration section of light source 110, perhaps as the integration section of laser instrument or flash unit (that is, comprising light source 110)-promptly, itself be configured to produce the light source of required pulse sequence.In addition, do not need independent " control unit 116 ".
In the example of Fig. 1 C, light-pulse generator 110 is embedded in the applicator 114 at Figure 1A.Replacedly or extraly, in certain embodiments, light-pulse generator 110 is positioned at outside the applicator 114, and light for example via the waveguide of some type or pipeline from " outside " light sources transmit to applicator 114.
In the exemplary embodiment, applicator 114 is cooled off to provide such as the cooling of using the contact cooling that applicator was provided (for example, such as the cooling of sapphire contact).In the embodiment relevant, preferably provide good thermal contact with the contact cooling.
Although being appreciated that does not need cooling, can use the cooling technology of combination in any, comprise pre-cooled, synchronous cooling, spray cooling, gel cooling, air cooling etc.
In the exemplary embodiment, use light pulse handle before and/or during and/or apply cooling afterwards.The amount of cooling in the exemplary embodiment, (for example, contact cooling and/or spray cooling or any other cooling) is for example determined according to one or more parameters of pulsed light by control unit 116 (for example, controller 215).
In the exemplary embodiment, light penetrates corium 54 corium for example is heated at least 42 degrees centigrade or at least 45 degrees centigrade.In the exemplary embodiment, hair follicle 50 is heated to the temperature higher than dermal temperature, for example is heated to thermal denaturation temperature.But this is not desired, and can destroy hair follicle and needn't be heated denaturation temperature.
Bound by theory ground is not noted, in the exemplary embodiment, because the dermal temperature of heat, hair follicle can not be cooled to be lower than the temperature of corium in special time period.When this situation occurring, for example can remove hair by waiting for alopecia and/or use tweezers etc.
In certain embodiments, the heating region of corium (or subcutis) is at least 20% or at least 50% or at least 80% of any hot spot disclosed herein (spot) area, and be heated minimum time section-for example, at least 0.5 second, at least 1 second, at least 2 seconds, or can be used for realizing the section At All Other Times arbitrarily of required hair follicle heating (and heat damage of hair follicle).
Fig. 2 illustrates the block diagram of exemplary control unit 116.As described in the early time, various parameters can manually be determined by the operator, and/or can use electronic circuit to calculate.Yet, provide specific " pre-programmed option " with more convenient.
The control unit 116 of the example of Fig. 2 comprises controller 215.Controller 215 is used for controlling at least in part one or more pulse characteristics, the persistent period that includes but not limited to pulse energy density, individual pulse (promptly, pulse width), persistent period, the umber of pulse in the pulse train and the pulsation rate of power parameter (for example, average and/or peak power), pulse train.
Therefore, in the example of Fig. 2, controller 215 comprises following one or more: the selector 213 of the umber of pulse of repetitive rate selector 210, energy density selector 212, individual pulse persistent period (or pulse width) selector 217, power selector 214 (be used for determining peak power for example and/or mean power and/or by these two parameter of releasing) and pulse train duration selector and/or pulse train.
Therefore, in different embodiment, controller 215 can be operated or programme provides specific pulse train with given repetitive rate, this pulse train comprises the pulse of minimal amount at least (for example, at least 3 pulses, at least 5 pulses, at least 10 pulses, at least 15 pulses or at least 30 pulses).
In certain embodiments, with control unit 116 " pre-configured " for selected processing scheme as described herein (for example, describing any processing scheme of repetitive rate and/or the pulse width in optical pulse energy density and/or pulse duration and/or power parameter) is provided at alopecia.In an example, the user can use certain type utilization the user interface (not shown) of display 216 from a plurality of schemes, select given processing scheme (for example, the scheme of current description).
In certain embodiments, a plurality of " programs " that are associated with given pulse train are provided, and the mechanism that is used to select specific program is provided.In an instantiation, provide the user interface that is used for selecting specific procedure according to skin and/or hair color.
For example, " light skin " program can provide higher energy density pulse, and but " skin down " program can provide lower energy density pulse for example higher repetitive rate.
In the exemplary embodiment, control unit comprises the user display that for example is used for option program.
Notice that in certain embodiments, the user can specify first parameter or parameter set (for example, energy density), and controller 215 can be determined or calculates another parameter (for example, repetitive rate) according to specified parameter or parameter set.
Notice that as shown in the figure, light source 110 " embedding " is (for example at the head place) in applicator.Some embodiment provides this marked feature, but this can not think a kind of restriction.
In the exemplary embodiment, can provide one or more users to import controller (for example, keyboard, foot switch etc.) (not shown).
Fig. 3 illustrates exemplary light source 110 (that is, pulse and/or CW light source).In the example of Fig. 3, it comprises pulse generator 310 (for example, by device control cell control), light source 312 (for example, laser instrument and/or such as the incoherent light source of flash lamp), and optical module 314.
Optical module 314 is configured to for example to change the propagation of electromagnetic radiation of relevant and/or incoherent light light is pointed to predetermined direction and/or precalculated position.Optical module can comprise and well known to a person skilled in the art any suitable optics that is used to carry out this function, includes but not limited to waveguide, lens (that is, including but not limited to refraction and diffraction lens) and mirror.Alternatively, in some embodiments relevant with the incoherent light depilation, optical module 314 can comprise band filter, for example, is used for carry out the low pass filter of filtering from the incoherent light of flash lamp.
Can programme so that the light of different wavelength range to be provided to flash lamp or other incoherent light source.
Note, without limits the shape of light pulse.In the exemplary embodiment, the shape of pulse is quadrate, but this is of course not restrictive, and the pulse of arbitrary shape (for example, sinusoidal, zigzag etc.) all within the scope of the invention.
Notice that coherent light (that is, from laser instrument) and incoherent light (that is, from flash lamp) are all within the scope of the invention.Typically, the facula area of incoherent light is bigger.Therefore, in relating to the exemplary embodiment of laser instrument, facula area is for example at 0.5cm 2And 2cm 2Between.In relating to the exemplary embodiment of incoherent light, facula area is for example at 3cm 2And 10cm 2Between, for example at 3cm 2And 7cm 2Between.
In certain embodiments, the interpulse time keeps constant.Perhaps, this parameter can change, so that the repetitive rate of change to be provided.
In certain embodiments, a marked feature that is provided by control unit is that light pulse can have different predetermined light radiation and/or pulse parameter, for example, and predetermined wavelength, energy density, repetitive rate, pulse shape etc.
Notice that in certain embodiments, the electromagnetic radiation except light radiation (for example, RF radiation) can apply simultaneously with light pulse.Yet this is not restrictive, and the embodiment that the overall strength of this non-optical energy accounts for total electromagnetic radiation intensity 10% at the most also within the scope of the invention.Usually, do not apply the RF radiation, and only apply light (relevant and/or incoherent), this is also nonrestrictive certainly.
As mentioned above, various parameters can change alternatively in time, for example repetitive rate, pulse shape, pulse width etc.
Note, in various embodiments, applied do not burn to remove hair (temporary transient and/or permanent depilation) surrounding tissue/skin and/or surrounding tissue/skin is preserved from of the electromagnetic radiation that comprises light pulse.
Extra discussion about processing scheme
In certain embodiments, patient's processing comprises step: (i) there is the zone (perhaps needing to destroy the zone of hair follicle) of hair follicle in the identification patient; (ii) apply the electromagnetic radiation that comprises a plurality of incoherent and/or coherent optical pulses; (iii) make hair follicle destroy by the electromagnetic radiation that is applied.
Following of impulse radiation and continuous-wave radiation (CW) applies
Fig. 4 shows and can realize with " high-average power " (that is, enough heat corium and remove hair) transmission light radiation with some kinds of different modes.In the example A of Fig. 4, with a series of low energy densities pulses (for example, 20J/cm at the most 2Every pulse, for example, at the most 15 or 10J/cm 2Every pulse) (for example, 1J/cm at least 2Every pulse) fast (3HZ at least for example, 4HZ at least for example, 5HZ at least for example, 8HZ at least for example, for example 10HZ at least) is transferred to patient's skin.By quick transmission " low energy densities pulse ", can in heating patient corium, certain quantity of energy be navigated to hair follicle and be beneficial to remove hair.In the example B of Fig. 4, CW energy (perhaps replacedly, a series of " long pulses ") is followed transmission with " short pulse ".According to example B, the energy density of each single short pulse can be less than the energy density among the example A, and/or the repetitive rate of the transmission of single short pulse can be less than among the example A.But as mentioned above, whole " average energy " still enough heats patient's corium.Be appreciated that for some example if the average energy of CW raises, the energy that is transmitted by " short pulse " can reduce, the total amount of the average energy of being transmitted simultaneously remains " height ".
Head or applicator speed
Bound by theory ground is not noted, uses burst transmissions speed or frequency relative to " height " to realize applying light pulse via the head that moves with the speed relative to " height " on skin surface.This be because, when burst transmissions speed was higher, the individual pulse that transmits in the section in preset time was more, even therefore handpiece speed " height " relatively, given hair follicle still can receive the pulse of minimal amount.
In the exemplary embodiment, on average, given processing region (for example, 1cm at least 2, or 5cm at least 2, or 10cm at least 2, or 50cm at least 2Given processing region) in each hair follicle receive 10 to 15 pulses.Be appreciated that and depend on concrete application, under some clinical settings, for example given hair follicle will be subjected at least 5 pulses, at the most 20 pulses or the pulse of other number arbitrarily.
In certain embodiments, by during the time period of transmitting a plurality of light pulses with given minimum average B configuration repetitive rate (for example, during the time period of at least 10 pulses of transmission, or during the time period of at least 20 pulses of transmission, or during the time period of at least 50 pulses of transmission, or during the time period of at least 75 pulses of transmission, or during the time period of at least 100 pulses of transmission), with average (or 4cm/ second at least 3cm/ second at least, or about 5cm/ second) speed on the surface of treatment surface (promptly, on skin surface) move or the applicator of " slip " or head (for example, provide simultaneously include but not limited to the refrigerative applicator of contact) apply a plurality of light pulses.
As used herein, applicator is worked as in " speed " expression of applicator or head or head (for example moves on the surface of processing region or skin, the part plan that is parallel to processing region) time, fixing point on applicator or the head (barycenter for example, or in another example, the lip-deep fixing point of energy process) with respect to the speed of processing region or skin.
Be appreciated that in different application, apply or transmit light pulse during the minimum of needed head or average speed can be depending on required intrusion degree of application-promptly depend on such as repetitive rate, facula area, processing etc. and different.
Therefore, in an example, if repetitive rate is higher, then can be in the light pulse of burst transmissions time durations transmission from head with fair speed or applicator.In another example, bigger facula area also will allow higher head or applicator speed.
In certain embodiments, the average handpiece speed during the burst transmissions (for laser or incoherent light) is 3cm/ second at least, 4cm/ second at least, or 5cm/ second at least.In certain embodiments, average head or applicator speed v are defined as at a plurality of light of transmission (promptly, relevant or incoherent light) during the time period of pulse, (v^2)/[(freq) ^2* (spot)] (wherein v is the speed of head or applicator, with cm/ second be unit, spot is a facula area, is unit with cm^2) be at least 0.1 or at least 0.3 or at least 0.5 or at least 0.7 or at least 1.
Bound by theory ground is noted, in certain embodiments, handles for depilation faster is provided, and can select to adopt the speed of " faster " or " higher " to the patient practitioner who handles of losing hair or feathers.
The subsequent treatment of the subregion of processing region
Fig. 5 A illustrates exemplary process zone 500.Notice that each subregion is a Mathematics structural.In the example of Fig. 5 A, each subregion is rectangular shape (total processing region 500 also is rectangular shape), but this can not think a kind of restriction.According to the example of Fig. 5 A, provide practitioner that depilation handles for example by on processing region, moving zones of different or the subregion that the head that is used to transmit light pulse is applied to light pulse processing region 500 to patient to Fig. 5 B.
Therefore, can handle successively.In an instantiation, during the processing procedure of processing region 500, use a plurality of light pulses that first subregion " A " 502 is handled 511; Use a plurality of light pulses that first subregion " B " 504 is handled 513 then; Use a plurality of light pulses that first subregion " C " 506 is handled 515 then; Use a plurality of light pulses that first subregion " D " 508 is handled 517 then; Use a plurality of light pulses that first subregion " E " 510 is handled 519 then.
This process can repeat inferior arbitrarily.As shown in Fig. 5 A, subscript i represents to carry out the i time processing to stator region.
In the example of Fig. 5 B, when when handling to stator region, other subregion is not being attempted (that is, because head or applicator in other position) at Fig. 5 A.Therefore, at interval t 1 1At first handle subregion " A " quilt during this time.Then, comprising interval t 2 1, t 3 1, t 4 1, t 5 1And t 6 1" residue " interval during, applicator is handled other subregion (that is, subregion " B " arrives " F ").Therefore, in this interim remaining time, subregion " A " 502 does not receive light pulse.Subsequently, at interval t 1 2During this time, subregion " A " 502 is subjected to a plurality of light pulses 511 once more.
Therefore, the process described in Fig. 5 B is the instantiation (that is, each subregion is subjected to a plurality of light pulses off and on) that light pulse " intermittently " applies, and will be described in the following.
Light pulse is beneficial to depilation to intermittently of the given position on the patient skin applying
In certain embodiments, not all pulse all is transferred to given position or the given hair follicle on the skin continuously or simultaneously.
Therefore, as described to Fig. 5 B with reference to figure 5A, can use a plurality of pulses to handle the first given subregion, (for example handle second subregion then, by applicator or head are moved to second subregion from first subregion, for example, by applicator is slided to arrive second subregion on the skin of processing region), first subregion will receive extra light pulse then.
Replacedly or extraly, in another example that light pulse " intermittently " applies, the pulse of some can be transferred to the specific region, a period of time afterwards, do not have burst transmissions to arrive and (for example handle the zone, the operator can for example use the temporary transient stop pulse transmission of foot switch), transmit the pulse of some afterwards once more.
In addition, be appreciated that in certain embodiments that the speed of applicator can be the function of processing region size.
Fig. 6 illustrates the flow chart that the given position of tissue or area be subjected to the example process of the light pulse that applied off and on-promptly, apply light pulse (step 401) in very first time section, then, during second time period (step 403), the tissue given position or area do not receive light pulse, more then, during the 3rd time period (promptly, the repetition of step 401), the given position of tissue or area are subjected to the light pulse that applied once more.Step 401 and 403 can repeat arbitrary number of times and remove hair with convenient from given position or area.
Therefore, in step 401, apply or transmit a series of light pulses (that is the pulse P that, comprises minimal amount) with given repetitive rate.In an example, light pulse is that mean energy density is 20J/cm at the most 2Every pulse, be 0.5J/cm at least 2The coherent optical pulse of every pulse.In another example, light pulse is that mean energy density is less than 8J/cm 2Every pulse and be 0.5J/cm at least 2The incoherent light pulses of every pulse (for example, from flash lamp).
As used herein, to certain area or zone transmission or apply one or more (incoherent or relevant) light pulse and can comprise with one or more positions of burst transmissions in this area or the zone.
Note, in certain embodiments, be transferred to this area or zone (promptly in step 401, the number P of the pulse one or more positions in this area or the zone) depends on the size of this area, wherein for example, comes at this bigger area than the more multiposition received pulse in the large tracts of land, so bigger area can receive more pulse owing to having bigger " ability ".
Therefore, in an example, if the area of tissue is N cm 2(that is, surface area is N cm 2), then the pulse number that transmits in step 401 is the smallest positive integral greater than 1.5N at least.
According to this example, the value of N can be in 1 to 20 scope, in 1.5 to 15 scope, and in 2 to 15 scope, and in other subrange.
In an instantiation, size is 1cm 2Organize area given head " process " in the time (that is, during the example in step 401) can receive 2 pulses.Similarly, in this example, size is 4cm 2The area of organizing in this instantiation, can receive 8 pulses in the time at given head " process ".
With reference now to step 403,, note, after having applied at least P light pulse, this zone or area (it can be or not be the subregion of bigger processing region) can be subjected to remaining pulse, wherein can not transmit light pulse (that is, be not transferred in this zone or the area optional position) or can be only apply or transmit the light that mean power reduces to this zone or area.
During the time period of step 403, given area or area can allow to cool off before repeating step 401.This is useful for safe processing is provided.
In an example, applicator applies energy elsewhere during the time period of step 403, does not need to apply any energy at Remaining Stages.This is described in Fig. 4 B at Fig. 4 A.Therefore, for subregion " A " 502, the execution first of step 401 is at interval t 1 1During this time.The execution first of step 403 is to comprise interval t 2 1, t 3 1, t 4 1, t 5 1And t 1 6Interval during.Carry out the second time of step 401 is at interval t 1 2During this time.
For subregion " B " 502, the execution first of step 401 is at interval t 2 1During this time.The execution first of step 403 is to comprise interval t 3 1, t 4 1, t 5 1, t 1 6And t 1 2Interval during.Carry out the second time of step 401 is at interval t 2 2During this time.
Notice that in various embodiments, this Remaining Stages can be " noenergy applies the stage " or " low-yield relatively apply stage ".
In an example, during " Remaining Stages " of step 403, transmit (for example, by be used to transmit head or applicator transmitted, promptly, in step 401, the mean power of light described a plurality of light pulse) (or the amount of light in the spectral regions between the total amount of light or 750nm and the 1500nm) is no more than certain " low-power " number-for example, be no more than 30 watts, or is no more than 20 watts, or be no more than 10 watts, or be no more than 5 watts.
In different embodiment, the persistent period in " residue " stage is for example invaded degree and/or all " processings " regional size and/or patient's physiological parameter (for example, hair or skin color) and/or one or more various factors and change according to required processing.
The skilled practitioner of handling is determined the length in " residue " stage according to a plurality of examples.Therefore, in different instances, the persistent period of " Remaining Stages " of step 403 continues to depend on a minimum time of one or more factors.Therefore, for example, given hair follicle can stand a certain amount of time of " Remaining Stages ", and this time is several seconds at least, be at the most depilation handle on the persistent period magnitude the time period-promptly, be a few minutes (for example, 20 minutes at the most, or 30 minutes, or 60 minutes) at the most.
In an example, for example with the example class of Fig. 5 A seemingly, remaining time, the length of section can be subjected to the influence with respect to the size of whole processing regions of the size of stator region.Therefore, if give the size of stator region less with respect to the size in entire process zone, then this can increase the time span of " section remaining time " of step 403.If give the size of stator region bigger with respect to the size in entire process zone, then this can reduce the time span of " section remaining time " of step 403.
Notice that the sum of the pulse of being transmitted can be depending on the size of processing region 500.In an example, this equipment can be preconfigured to the transmission pulse of certain number at least (or being programmed for the pulse of transmitting arbitrary number), for example, at least 15, at least 30, at least 50, at least 100, and at least 500.In addition, in different instances, providing user that depilation handles or practitioner can control to stop transmission pulse (temporarily or fully).
Following example is only thought illustrative and nonrestrictive in itself.For those skilled in the art in the invention, obviously can carry out many modifications, displacement and distortion and do not depart from the scope of the present invention.
Example
The inventor has carried out various experiments to be proved by apply light radiation according to one or more instructions disclosed herein and carries out human body depilation.In example 1-2, some experiments of carrying out have been described.In example 3, other exemplary arrangement and the equipment configuration parameter relevant with incoherent light have been described.
Example 1: use the depilation of diode laser
The inventor has constructed exemplary diode laser Depilatory device, and this equipment has been disposed in some instruction according to the present invention.The inventor has carried out some and has tested the depilation that the use aforementioned device is described.
Below shown in table 1 listed configuration parameter at the employed various optical fields of concrete experimental session.At this experimental session, a series of square pulses are imposed on skin, wherein for all pulses concerning, pulse between time equate.
Parameter value
Wavelength 810nm
Energy density 10J/cm 2Every pulse
Pulse length 22ms
Facula area 1.0cm 2
Pulse frequency (repetitive rate) 10 pulse/sec
450 watts of peak powers
Mean power～100 watt
After having applied a plurality of light pulses, observe hair and be removed.For the concrete experiment of this group, observe after 3 months: after applying light pulse, have at least 3 months hairs not have significant regrowth (that is regrowth rate, is less than 30%) in the zone of handling.Be appreciated that hair does not have the time of remarkable regrowth to be not limited to current observed 3 months, it also will continue.
Example 2: use the depilation of incoherent intense pulsed light
The inventor has constructed exemplary flash lamp Depilatory device, and this equipment has been disposed in some instruction according to the present invention.The inventor has carried out some and has tested the depilation that the use aforementioned device is described.
In this exemplary apparatus, use low pass filter that wavelength is carried out filtering less than 780nm with greater than the light of 1300nm.
Below shown in table 2 listed at the employed various optical field configuration parameters of concrete experimental session.At this experimental session, a series of square pulses are imposed on skin, wherein for all pulses concerning, pulse between time equate.
Parameter value
Energy density 5J/cm 2
Pulse duration 6ms
Facula area 6.4cm 2
Pulse frequency (repetitive rate) 3 pulse/sec
Peak power 5 * 1/0.006 * 6.4=5,330W
Mean power 5x6.4x3=96W
Example 3: use the depilation of incoherent intense pulsed light
Example 3 has been described the another kind of equipment relevant with incoherent light (for example, IPL or flash of light) or has been handled non-limiting parameter.
Parameter value
Energy density 2J/cm 2
Pulse duration 2ms
Facula area 6.4cm 2
Pulse frequency (repetitive rate) 10 pulse/sec
Peak power 2 * 1/0.002 * 6.4=6,400W
Mean power 2x6.4x10=128W
In the application's description and claim, the object that each verb " comprises ", " comprising ", " having " and changing all is used to represent this verb is the enumerating of element, parts, element or part of the subject of this verb fully not necessarily.
Here all lists of references of being quoted are all introduced fully.To quoting of list of references is not to admit that this list of references is a prior art.
Here employed article " ", " one " refer to one or more than the phraseological object of (that is, at least one) this article.For example, " element " element of expression or more than an element.
Here employed term " comprise " the expression phrase " including, but not limited to ", and interchangeable with it.
Employed here term " or " the expression term " and/or ", and interchangeable with it, unless context has clearly illustrated that other implication.
Here employed term " such as " the expression phrase " such as but be not limited to ", and interchangeable with it.
Used provide by example but not the detailed description of the embodiment that limits the scope of the invention invention has been described.Described embodiment comprises different characteristic, and not all these features all are essential in all embodiment of the present invention.Some embodiments of the present invention have only been utilized may making up of some features or feature.The distortion of described embodiments of the invention and the embodiments of the invention that include in described embodiment the various combination of the feature of indicating it will be apparent to those skilled in the art that.

Claims (218)

1, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of coherent optical pulses is applied to described tissue regions, and wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, is the maximum wavelength value that is at most 1500nm at the most, wherein:
I) the average pulse energy density of described a plurality of pulses is to be at least 3J/cm at least 2The minimum average B configuration energy density values, be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And
Iii) the average pulse persistent period of described light pulse is at least 1 millisecond.
2, method according to claim 1, wherein said minimum wavelength value is 780nm at least, and described maximum wavelength value is 1000nm at the most.
3, method according to claim 1, the described average pulse persistent period of wherein said pulse is 4 milliseconds at least.
4, method according to claim 1, the described average pulse persistent period of wherein said pulse is 10 milliseconds at least.
5, method according to claim 1, the described average pulse persistent period of wherein said pulse is 25 milliseconds at the most.
6, method according to claim 1 wherein applies at least 5 described pulses with described average repetitive rate.
7, method according to claim 1 wherein applies at least 15 described pulses with described average repetitive rate.
8, method according to claim 1 wherein applies at least 30 described pulses with described average repetitive rate.
9, method according to claim 1, every square centimeter average power density of the wherein said electromagnetic energy that applies is to be at least 50 watts/cm at least 2The minimum average B configuration power density values.
10, method according to claim 9, wherein said minimum average B configuration power density values is 75 watts/cm at least 2
11, method according to claim 9, wherein said minimum average B configuration power density values is 100 watts/cm at least 2
12, method according to claim 9, wherein said average power density are the described minimum average B configuration power density values during time period when applying at least 5 described pulses with described average repetitive rate at least.
13, method according to claim 9, wherein said average power density are the described minimum power density value during time period when applying at least 15 described pulses with described average repetitive rate at least.
14, method according to claim 9, wherein said average power density are the described minimum power density value during time period when applying at least 30 described pulses with described average repetitive rate at least.
15, method according to claim 9, wherein said average power density are the described minimum power density value that is at least during time period of 1 second at least.
16, method according to claim 9, wherein said average power density are the described minimum power density value that is at least during time period of 2 seconds at least.
17, method according to claim 9, wherein said average power density are the described minimum power density value that is at least during time period of 3 seconds at least.
18, method according to claim 1, wherein the average power density of the electromagnetic energy that is applied is to be at most 250 watts/cm at the most 2The maximum power density value.
19, method according to claim 18, wherein said maximum power density value is 150 watts/cm at the most 2
20, method according to claim 18, wherein said average power density are the described maximum power density value during time period of at least 1 second at the most.
21, method according to claim 18, wherein said average power density are the described maximum power density value during time period of at least 2 seconds at the most.
22, method according to claim 18, wherein said average power density are the described maximum power density value during time period of at least 3 seconds at the most.
23, method according to claim 1, wherein the mean power of the electromagnetic energy that is applied is to be at least 50 watts minimum average B configuration performance number at least.
24, method according to claim 23, wherein said minimum average B configuration performance number is 75 watts at least.
25, method according to claim 23, wherein said minimum average B configuration performance number is 100 watts at least.
26, method according to claim 23, wherein said mean power are the described minimum average B configuration performance number during time period when applying at least 5 described pulses with described average repetitive rate at least.
27, method according to claim 23, wherein said mean power are the described minimal power values during time period when applying at least 15 described pulses with described average repetitive rate at least.
28, method according to claim 23, wherein said mean power are the described minimal power values during time period when applying at least 30 described pulses with described average repetitive rate at least.
29, method according to claim 23, wherein said mean power are the described minimal power values that is at least during time period of 1 second at least.
30, method according to claim 23, wherein said mean power are the described minimal power values that is at least during time period of 2 seconds at least.
31, method according to claim 23, wherein said mean power are the described minimal power values during time period of 3 seconds at least.
32, method according to claim 1, the mean power of the wherein said electromagnetic energy that applies are to be at most 250 watts maximum power value at the most.
33, method according to claim 32, wherein said maximum power density value is 150 watts at the most.
34, method according to claim 32, wherein said mean power are the described maximum power value during time period of at least 1 second at the most.
35, method according to claim 32, wherein said mean power are the described maximum power value during time period of at least 2 seconds at the most.
36, method according to claim 1, wherein said mean power are the described maximum power value during time period of at least 3 seconds at the most.
37, method according to claim 1, wherein said minimum repetition values is 7.5HZ at least.
38, method according to claim 1, the average repetitive rate of wherein said a plurality of pulses are the maximum repetition values that is at most 20HZ at the most.
39, method according to claim 1, wherein said maximum repetition values is 15HZ at the most.
40, method according to claim 1, wherein said maximum mean energy density value is 15J/cm at the most 2
41, method according to claim 1, wherein said maximum mean energy density value is 12.5J/cm at the most 2
42, method according to claim 1, wherein said maximum mean energy density value is 10J/cm at the most 2
43, method according to claim 1, wherein said minimum average B configuration energy density values is 5J/cm at least 2
44, method according to claim 1, wherein said minimum average B configuration energy density values is 7.5J/cm at the most 2
45, method according to claim 1, the pulse energy density standard deviation of wherein said a plurality of pulses is to be at most 0.5 standard deviation value with the ratio of the described average pulse energy density of described a plurality of pulses at the most.
46, according to the described method of claim 45, wherein said standard deviation is 0.2 than at the most.
47, method according to claim 1, wherein the electromagnetic energy that is applied is used for the subcutis of skin area is heated to the minimum temperature of at least 42 degree.
48, according to the described method of claim 47, wherein said minimum temperature is 45 degree at least.
49, method according to claim 1, the wherein said electromagnetic energy that applies are used for the subcutis of skin area is heated to the maximum temperature of 50 degree at the most.
50, method according to claim 1, the ratio of the peak power of wherein said coherent optical pulse and mean power are to be at least 1.5 minimum power ratio at least.
51, according to the described method of claim 50, wherein said minimum power is 2 than at least.
52, according to the described method of claim 51, described minimum power is 5 than at least.
53, method according to claim 1, the peak power of wherein said coherent optical pulse is to be at most 20 maximum power ratio with the ratio of mean power at the most.
54, according to the described method of claim 53, wherein said maximum power ratio is 15 at the most.
55, according to the described method of claim 53, wherein said maximum power ratio is 10 at the most.
56, method according to claim 1, the peak power of the wherein said electromagnetic energy that applies are to be at most 1500 watts maximum peak power value at the most.
57, according to the described method of claim 60, wherein said maximum peak power value is 1000 watts at the most.
58, method according to claim 1, the facula area of wherein said coherent light is at 0.5cm 2To 2cm 2Between.
59, according to the described method of claim 58, wherein said facula area surpasses 1.2cm 2
60, method according to claim 1, the described average pulse energy density of wherein said a plurality of pulses and the ratio of described average repetitive rate are the (J * s)/cm that is at most 3 at the most 2Maximum ratio.
61, according to the described method of claim 60, wherein said maximum ratio is 2.5 at the most (J * s)/cm 2
62, according to the described method of claim 60, wherein said maximum ratio is 2 at the most (J * s)/cm 2
63, according to the described method of claim 60, wherein said maximum ratio is 1.5 at the most (J * s)/cm 2
64, according to the described method of claim 60, wherein said maximum ratio is 1 at the most (J * s)/cm 2
65, method according to claim 1, wherein said average pulse energy density is to be at most 1.5J/ (cm with the ratio of described average pulse persistent period at the most 2* ms) maximum ratio.
66, according to the described method of claim 65, wherein said maximum ratio is 1J/ (cm at the most 2* ms).
67, according to the described method of claim 65, wherein said maximum ratio is 0.75J/ (cm at the most 2* ms).
68, method according to claim 1, the size of wherein said tissue regions are 2cm at least 2And be 1000cm at the most 2
69, method according to claim 1, the step that wherein applies described coherent optical pulse comprise uses diode laser to produce described coherent light.
70, method according to claim 1, wherein by above the described tissue regions, make the applicator that has the gap between the surface of the lower surface of described applicator and described tissue regions transmit described electromagnetic energy.
71, method according to claim 1, wherein said electromagnetic energy is transmitted by applicator, and described applicator comprises:
I) transparent transfer surface; And
Ii) spacer shell,
Described applicator is configured to, and when the surface engagement of applicator and tissue regions, described transparent transfer surface is in the surface of described tissue regions.
72, method according to claim 1, wherein use applicator to carry out and apply the described electromagnetic energy that comprises described a plurality of pulses, described applicator moves the minimum applicator distance of 2cm at least at least on the surface of described tissue regions, the applicator velocity amplitude when it moves is to be at least the minimum applicator velocity amplitude of 1cm/sec at least and is the maximum applicator velocity amplitude that is at most 20cm/sec at the most.
73, according to the described method of claim 72, wherein said minimum applicator distance is 3cm at least.
74, according to the described method of claim 72, wherein said minimum applicator speed is 3.5cm/sec at least.
75, according to the described method of claim 72, wherein said maximum applicator speed is 10cm/sec at the most.
76, according to the described method of claim 72, wherein said maximum applicator speed is 6.5cm/sec at the most.
77, method according to claim 1 also comprises:
B) at least a portion of the described tissue of cooling.
78, method according to claim 1 wherein carries out describedly applying described electromagnetic energy and do not cool off described tissue regions.
79, method according to claim 1, wherein said applying comprises:
I) set up the energy stage, wherein surface area is 2cm 2The given area stand the described electromagnetic energy that applies that comprises described a plurality of pulses that applies with described average repetitive rate; And
Ii) at described energy after the stage, set up Remaining Stages for described given area immediately, the persistent period of described Remaining Stages is 2 seconds at least and is the persistent period in maximum residual stage at the most, the described persistent period in maximum residual stage is 60 minutes at the most, thereby during described Remaining Stages, the wavelength that is applied to described tissue regions is 750nm at least and is that the mean power of the electromagnetic energy that is applied of 1500nm is 30 watts at the most at the most;
Iii) after described Remaining Stages, to described given tissue regions repeating step (a) and (b) at least M time, M is that value is at least 1 integer immediately.
80, according to the described method of claim 79, the wherein said Remaining Stages persistent period is 10 seconds at least.
81, according to the described method of claim 79, the wherein said Remaining Stages persistent period is 30 seconds at least.
82, according to the described method of claim 79, the wherein said Remaining Stages persistent period is 90 seconds at least.
83, according to the described method of claim 79, the wherein said Remaining Stages persistent period is 10 minutes at the most.
84, according to the described method of claim 79, the wherein said Remaining Stages persistent period is 5 minutes at the most.
85, according to the described method of claim 79, wherein M is 2 at least.
86,5 described methods according to Claim 8, wherein M is 3 at least.
87, according to the described method of claim 79, wherein:
For each described energy stage of a plurality of described Remaining Stages, the energy density that applies for the accumulation of the described electromagnetic energy that applies in described each energy stage is 20 joules/cm in time period of 20 minutes at the most at least 2, and be 200 joules/cm at the most 2
88, method according to claim 1, the described electromagnetic energy that wherein will comprise described pulse is applied to light skin.
89, method according to claim 1, the described electromagnetic energy that wherein will comprise described pulse are applied to the tissue that contains low melanin hair, to destroy described low melanin hair.
90, method according to claim 1, the described electromagnetic energy that wherein will comprise described pulse is applied to the skin of Fitzpatrick Class1-3, to destroy the hair that is associated with Fitzpatrick Class1-3.
91, method according to claim 1, the described electromagnetic energy that wherein will comprise described pulse is applied to the skin of Fitzpatrick type 4-6, to destroy the hair that is associated with Fitzpatrick type 4-6.
92, method according to claim 1 wherein is applied to described electromagnetic energy described tissue to destroy the low melanin hair that is associated with this tissue.
93, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of light pulses is applied to described tissue regions, and each described light pulse mainly comprises wave-length coverage at the minimum wavelength value of 750nm at least and one or more wavelength between the maximum wavelength value of 1500nm at the most, wherein:
I) ratio of the average pulse energy density of described a plurality of light pulses and the repetitive rate of described a plurality of light pulses is the (J * s)/cm that is at most 3 at the most 2Maximum ratio; And
Ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
94, according to the described method of claim 93, wherein said a plurality of light pulses comprise the coherent optical pulse of wavelength in described wave-length coverage.
95, according to the described method of claim 93, wherein said a plurality of light pulses comprise the incoherent light pulses of wavelength in described wave-length coverage.
96, according to the described method of claim 93, at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
97, according to the described method of claim 93, at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
98, according to the described method of claim 93, wherein said maximum ratio is 2J/ (cm at the most 2* ms).
99, according to the described method of claim 93, wherein said maximum ratio is 1.5J/ (cm at the most 2* ms).
100, according to the described method of claim 93, wherein said maximum ratio is 1J/ (cm at the most 2* ms).
101, according to the described method of claim 93, wherein said maximum ratio is 0.75J/ (cm at the most 2* ms).
102, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of light pulses is applied to described tissue regions, and wherein each described light pulse mainly comprises wave-length coverage at the minimum wavelength value of 750nm at least and one or more wavelength between the maximum wavelength value of 1500nm at the most, wherein:
I) the average pulse energy density of described a plurality of pulses is to be at most 1.5J/ (cm with the ratio of the average pulse persistent period of described pulse at the most 2* ms) maximum; And
Ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
103, according to the described method of claim 102, wherein said a plurality of light pulses comprise the coherent optical pulse of wavelength in described wave-length coverage.
104, according to the described method of claim 102, wherein said a plurality of light pulses comprise the incoherent light pulses of wavelength in described wave-length coverage.
105, according to the described method of claim 102, at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
106, according to the described method of claim 102, at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
107, according to the described method of claim 102, wherein said maximum ratio is 1J/ (cm at the most 2* ms).
108, according to the described method of claim 102, wherein said maximum ratio is 0.75J/ (cm at the most 2* ms).
109, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of coherent optical pulses is applied to described tissue regions, and wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, and is the maximum wavelength value that is at most 1500nm at the most, wherein:
I) the average pulse energy density of described a plurality of pulses is to be at least 5J/cm at least 2The minimum average B configuration energy density values, and be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 7.5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 7.5 milliseconds at least, and is 25 milliseconds at the most; And
Iv) apply at least 15 described pulses with described average repetitive rate.
110, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive method, described method comprises:
A) electromagnetic energy that will comprise a plurality of coherent optical pulses is applied to described tissue regions, and wherein said relevant light wavelength is the minimum wavelength value that is at least 750nm at least, and is the maximum wavelength value that is at most 1500nm at the most, wherein:
I) the average pulse energy density of described a plurality of pulses is the minimum average B configuration energy density values that is at least 5J/cm2 at least, and is the maximum mean energy density value that is at most 20J/cm2 at the most;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 7.5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 7.5 milliseconds at least, and is 25 milliseconds at the most;
Iv) the mean power of described a plurality of pulses is 60 watts at least; And
Iv) apply at least 15 described pulses with described average repetitive rate.
111, a kind of hair follicle in the tissue regions with a plurality of hair follicles is carried out destructive device, described device comprises:
A) coherent source is used to produce the coherent light that comprises a plurality of coherent optical pulses, and the wavelength of wherein said coherent optical pulse is the minimum wavelength value that is at least 750nm at least, and is the maximum wavelength value that is at most 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and described source and described controller are configured so that:
I) the average pulse energy density of described a plurality of pulses is to be at least 3J/cm at least 2The minimum average B configuration energy density values, and be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
112, according to the described device of claim 111, wherein said minimum wavelength value is 780nm at least, and described maximum wavelength value is 1000nm at the most.
113, according to claim 111 or 112 described devices, wherein said source and described controller are configured so that the described average pulse persistent period of described pulse is 4 milliseconds at least.
114, according to each described device in the claim 111 to 113, wherein said source and described controller are configured so that the described average pulse persistent period of described pulse is 10 milliseconds at least.
115, according to each described device in the claim 111 to 114, wherein said source and described controller are configured so that the described average pulse persistent period of described pulse is 25 milliseconds at the most.
116, according to each described device in the claim 111 to 115, wherein said source and described controller are configured to provide at least 5 described pulses with described average repetitive rate.
117, according to each described device in the claim 111 to 115, wherein said source and described controller are configured to provide at least 15 described pulses with described average repetitive rate.
118, according to each described device in the claim 111 to 117, wherein said source and described controller are configured to provide at least 30 described pulses with described average repetitive rate.
119, according to each described device in the claim 111 to 118, the average power density that wherein said source and described controller are configured to every square centimeter provides the described coherent light that comprises described a plurality of pulses, and described every square centimeter average power density is to be at least 50 watts/cm at least 2The minimum average B configuration power density values.
120, according to the described device of claim 119, wherein said minimum average B configuration power density values is 75 watts/cm at least 2
121, according to the described device of claim 119, wherein said minimum average B configuration power density values is 100 watts/cm at least 2
122, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to, when producing at least 5 described pulses with described average repetitive rate, providing is described every square centimeter average power density of described minimum average B configuration power density values at least.
123, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to, when producing at least 15 described pulses with described average repetitive rate, providing is described every square centimeter average power density of described minimum average B configuration power density values at least.
124, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to, when producing at least 30 described pulses with described average repetitive rate, providing is described every square centimeter average power density of described minimum average B configuration power density values at least.
125, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to the average power density that is described every square centimeter of providing of described minimum average B configuration power density values was at least kept 1 second at least.
126, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to the average power density that is described every square centimeter of providing of described minimum average B configuration power density values was at least kept 2 seconds at least.
127, according to each described device in the claim 119 to 121, wherein said source and described controller are configured to the average power density that is described every square centimeter of providing of described minimum average B configuration power density values was at least kept 3 seconds at least.
128, according to each described device in the claim 119 to 127, the average power density that wherein said source and described controller are configured to every square centimeter provides the described coherent light that comprises described a plurality of pulses, and described every square centimeter average power density is 250 watts/cm at the most at the most 2The maximum average power density value.
129, according to the described device of claim 128, wherein said maximum power density value is 150 watts/cm at the most 2
130, according to claim 128 or 129 described devices, wherein said source and described controller are configured to the transmission that is described every square centimeter average power density of described minimum average B configuration power density values was at least kept 1 second at least.
131, according to claim 128 or 129 described devices, wherein said source and described controller are configured to the transmission that is described every square centimeter average power density of described minimum average B configuration power density values was at least kept 2 seconds at least.
132, according to claim 128 or 129 described devices, wherein said source and described controller are configured to the transmission that is described every square centimeter average power density of described minimum average B configuration power density values was at least kept 3 seconds at least.
133, according to each described device in the claim 111 to 118, wherein said source and described controller are configured to being that the mean power that is at least 50 watts minimum average B configuration performance number is operated at least.
134, according to the described device of claim 133, wherein said minimum average B configuration performance number is 75 watts at least.
135, according to the described device of claim 133, wherein said minimum average B configuration performance number is 100 watts at least.
136, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to operate with described mean power, and described mean power is the described minimum average B configuration performance number during time period when applying at least 5 described pulses with described average repetitive rate at least.
137, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to operate with described mean power, and described mean power is the described minimum average B configuration performance number during time period when applying at least 15 described pulses with described average repetitive rate at least.
138, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to operate with described mean power, and described mean power is the described minimum average B configuration performance number during time period when applying at least 30 described pulses with described average repetitive rate at least.
139, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 1 second at least.
140, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 2 seconds at least.
141, according to each described device in the claim 133 to 135, wherein said source and described controller are configured to the described mean power that is described minimum average B configuration performance number was at least kept 3 seconds at least.
142, according to each described device in claim 111 to 118 or the claim 133 to 141, wherein said source and described controller are configured to being that the mean power that is at least 250 watts maximum average power value is operated at the most.
143, according to the described device of claim 142, wherein said maximum power density value is 150 watts at the most.
144, according to claim 142 or 143 described devices, wherein said source and described controller are configured to the described mean power that is described maximum average power value was at the most kept 1 second at least.
145, according to claim 142 or 143 described devices, wherein said source and described controller are configured to the described mean power that is described maximum average power value was at the most kept 2 seconds at least.
146, according to claim 142 or 143 described devices, wherein said source and described controller are configured to the described mean power that is described maximum average power value was at the most kept 3 seconds at least.
147, according to each described device in the claim 111 to 146, wherein said source and described controller are configured so that described minimum repetition values is 7.5HZ at least.
148, according to each described device in the claim 111 to 147, wherein said source and described controller are configured so that the average repetitive rate of described a plurality of pulses is the maximum repetition values that is at most 20HZ at the most.
149, according to each described device in the claim 111 to 148, wherein said source and described controller are configured so that described maximum repetition values is 15HZ at the most.
150, according to each described device in the claim 111 to 149, wherein said source and described controller are configured so that described maximum mean energy density value is 15J/cm at the most 2
151, according to each described device in the claim 111 to 149, wherein said source and described controller are configured so that described maximum mean energy density value is 12.5J/cm at the most 2
152, according to each described device in the claim 111 to 149, wherein said source and described controller are configured so that described maximum mean energy density value is 10J/cm at the most 2
153, according to each described device in the claim 111 to 152, wherein said source and described controller are configured so that described minimum average B configuration energy density values is 5J/cm at least 2
154, according to each described device in the claim 111 to 153, wherein said source and described controller are configured so that described minimum average B configuration energy density values is 7.5J/cm at the most 2
155, according to each described device in the claim 111 to 154, the pulse energy density standard deviation that wherein said source and described controller are configured so that described a plurality of pulses is to be at most 0.5 standard deviation ratio with the ratio of the described average pulse energy density of described a plurality of pulses at the most.
156, according to the described device of claim 155, wherein said standard deviation is 0.2 than at the most.
157, according to each described device in the claim 111 to 156, wherein said source and described controller are configured to provide described coherent light, make the described coherent light that provides be used for the subcutis of skin area is heated to the minimum temperature of at least 42 degree.
158, according to the described device of claim 157, wherein said minimum temperature is 45 degree at least.
159, according to each described device in the claim 111 to 158, wherein said source and described controller are configured to provide described coherent light, make that the described coherent light that provides is used for the subcutis of skin area is heated to the maximum temperature of 50 degree at the most.
160, according to each described device in the claim 111 to 159, the ratio of peak power and mean power that wherein said source and described controller are configured so that to comprise the described coherent light of described coherent optical pulse is to be at least 1.5 minimum power ratio at least.
161, according to the described device of claim 160, wherein said minimum power is 2 than at least.
162, according to the described device of claim 161, wherein said minimum power is 5 than at least.
163, according to each described device in the claim 111 to 162, the ratio of peak power and mean power that wherein said source and described controller are configured so that to comprise the described coherent light of described coherent optical pulse is to be at most 20 maximum power ratio at the most.
164, according to the described device of claim 163, wherein said maximum power ratio is 15 at the most.
165, according to the described device of claim 163, wherein said maximum power ratio is 10 at the most.
166, according to each described device in the claim 111 to 165, wherein said source and described controller are configured to provide the peak power of described coherent optical pulse, and described peak power is to be at most 1500 watts maximum peak power value at the most.
167, according to the described device of claim 260, wherein said maximum peak power value is 1000 watts at the most.
168, according to each described device in the claim 111 to 167, wherein said device is used to provide facula area at 0.5cm 2And 2cm 2Between described coherent light.
169, according to the described device of claim 168, wherein said facula area surpasses 1.2cm 2
170, according to each described device in the claim 111 to 169, the described average pulse energy density that wherein said source and described controller are configured so that described a plurality of pulses and the ratio of described average repetitive rate are the (J * s)/cm that is at most 3 at the most 2Maximum ratio.
171, according to the described device of claim 170, wherein said maximum ratio is 2.5 at the most (J * s)/cm 2
172, according to the described device of claim 170, wherein said maximum ratio is 2 at the most (J * s)/cm 2
173, according to the described device of claim 170, wherein said maximum ratio is 1.5 at the most (J * s)/cm 2
174, according to the described device of claim 170, wherein said maximum ratio is 1 at the most (J * s)/cm 2
175, according to each described device in the claim 111 to 174, wherein said source and described controller are configured so that described average pulse energy density and the ratio of described average pulse persistent period are to be at most 1.5J/ (cm at the most 2* ms) maximum ratio.
176, according to the described device of claim 175, wherein said maximum ratio is 1J/ (cm at the most 2* ms).
177, according to the described device of claim 175, wherein said maximum ratio is 0.75J/ (cm at the most 2* ms).
178, according to the described device of claim 175, wherein said maximum ratio is 0.6J/ (cm at the most 2* ms).
179, according to each described device in the claim 111 to 178, the step that wherein applies described coherent optical pulse comprises uses diode laser to produce described coherent optical pulse.
180, according to the described device of claim 111, wherein said coherent source comprises diode laser.
181, according to the described device of claim 180, also comprise:
D) cooling package is used at least a portion of cools tissue.
182, according to the described device of claim 181, wherein said cooling package is selected from the group that is made of contact cooling package and spray cooling assembly.
183, according to each described device in the claim 111 to 180, also comprise:
C) optical module, the described coherent light that is used for comprising described coherent optical pulse points to tissue regions.
184, according to the described device of claim 183, wherein said optical module comprises that light transmitting surface, surface area with substantially flat are at least 0.8cm 2The light transmission component of substantially transparent.
185, according to the described device of claim 184, also comprise
D) applicator shell is used to hold the light transmitting surface of described substantially flat, and described applicator is configured so that under the situation of the surface engagement of applicator and tissue regions, and described transparent transfer surface is in the surface of tissue regions.
186, according to each described device in the claim 183 to 185, also comprise
D) cooling package is used at least a portion of cools tissue.
187, according to the described device of claim 186, wherein said cooling package is selected from the group that is made of contact cooling package and spray cooling assembly.
188, a kind of device that is used for removing hair from tissue regions with a plurality of hair follicles, described device comprises:
A) coherent source is used to produce the coherent light that comprises a plurality of coherent optical pulses, and the wavelength of wherein said coherent optical pulse is the minimum wavelength value that is at least 750nm at least, and is the maximum wavelength value that is at most 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and described source and described controller are configured so that:
I) the average pulse energy density of described a plurality of pulses is to be at least 0.5J/cm at least 2The minimum average B configuration energy density values, and be to be at most 20J/cm at the most 2Maximum mean energy density value;
Ii) the average repetitive rate of described a plurality of pulses is the minimum repetition values that is at least 5HZ at least; And
Iii) the average pulse persistent period of described light pulse is 1 millisecond at least.
189, a kind of device that is used for removing hair from tissue regions with a plurality of hair follicles, described device comprises:
A) light source is used to produce the light that comprises a plurality of light pulses, and each described light pulse mainly comprises wave-length coverage and is being the minimum wavelength value of 750nm at least and is being one or more wavelength between the maximum wavelength value of 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and wherein said source and described controller are configured so that:
I) ratio of the average pulse energy density of described a plurality of light pulses and the repetitive rate of described a plurality of light pulses is the (J * s)/cm that is at most 3 at the most 2Maximum ratio; And
Ii) the average pulse persistent period of described light pulse is 1 millisecond at least.
190, according to the described device of claim 189, wherein said light source comprises and is configured so that described a plurality of light pulse comprises the coherent source of the coherent optical pulse of wavelength in described wave-length coverage.
191, according to the described device of claim 189, wherein said light source comprises and is configured so that described a plurality of light pulse comprises the incoherent light source of the incoherent light pulses of wavelength in described wave-length coverage.
192, according to the described device of claim 191, wherein said incoherent light source is configured so that at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
193, according to the described device of claim 191, wherein said incoherent light source is configured so that at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
194, according to each described device in the claim 189 to 193, wherein said maximum ratio is 2J/ (cm at the most 2* ms).
195, according to each described device in the claim 189 to 193, wherein said controller and described light source are configured so that described maximum ratio is 1.5J/ (cm at the most 2* ms).
196, according to each described device in the claim 189 to 193, wherein said controller and described light source are configured so that described maximum ratio is 1J/ (cm at the most 2* ms).
197, according to each described device in the claim 189 to 193, wherein said controller and described light source are configured so that described maximum ratio is 0.75J/ (cm at the most 2* ms).
198, according to claim 189 190 or claim 194 to 197 in each described device, wherein said coherent source comprises diode laser.
199, according to each described device in the claim 189 to 198, also comprise:
C) optical module, the described coherent light that is used for comprising described coherent optical pulse points to tissue regions.
200, according to the described device of claim 199, wherein said optical module comprises that light transmitting surface, surface area with substantially flat are at least 0.8cm 2The light transmission component of substantially transparent.
201, according to the described device of claim 200, also comprise:
D) applicator shell is used to hold the light transmitting surface of described substantially flat, and described applicator is configured so that under the situation of the surface engagement of applicator and tissue regions, and described transparent transfer surface is in the surface of tissue regions.
202, according to each described device in the claim 189 to 201, also comprise:
D) cooling package is used at least a portion of cools tissue.
203, according to the described device of claim 202, wherein said cooling package is selected from the group that is made of contact cooling package and spray cooling assembly.
204, a kind of device that is used for removing hair from tissue regions with a plurality of hair follicles, described device comprises:
A) light source is used to produce the light that comprises a plurality of coherent optical pulses, and the wavelength of described coherent optical pulse is the minimum wavelength value that is at least 750nm at least, is the maximum wavelength value that is at most 1500nm at the most; And
B) controller is used for controlling at least in part the pulse characteristic of described light pulse, and wherein said source and described controller are configured so that:
I) the average pulse energy density of described a plurality of pulses is to be at most 1.5J/ (cm with the ratio of the average pulse persistent period of described pulse at the most 2* ms) maximum; And
The average pulse persistent period of ii) described light radiation pulse is 1 millisecond at least.
205, according to the described device of claim 204, wherein said light source comprises and is configured so that described a plurality of light pulse comprises the coherent source of the coherent optical pulse of wavelength in described wave-length coverage.
206, according to the described device of claim 204, wherein said light source comprises and is configured so that described a plurality of light pulse comprises the incoherent light source of the incoherent light pulses of wavelength in described wave-length coverage.
207, according to the described device of claim 206, wherein said incoherent light source is configured so that at least 75% incoherent light wavelength of described incoherent light pulses is in described scope.
208, according to the described device of claim 206, wherein said incoherent light source is configured so that at least 95% incoherent light wavelength of described incoherent light pulses is in described scope.
209, according to each described device in the claim 204 to 208, wherein said source and described controller are configured so that described maximum ratio is 1J/ (cm at the most 2* ms).
210, according to each described device in the claim 204 to 208, wherein said source and described controller are configured so that described maximum ratio is 0.75J/ (cm at the most 2* ms).
211, according to each described device in each or the claim 209 to 210 in the claim 204 to 204, wherein said coherent source comprises diode laser.
212, according to each described device in the claim 204 to 211, also comprise:
C) optical module, the described coherent light that is used for comprising described coherent optical pulse points to tissue regions.
213, according to the described device of claim 212, wherein said optical module comprises that light transmitting surface, surface area with substantially flat are at least 0.8cm 2The light transmission component of substantially transparent.
214, according to the described device of claim 213, also comprise:
D) applicator shell is used to hold the light transmitting surface of described substantially flat, and described applicator is configured so that under the situation of the surface engagement of applicator and tissue regions, and described transparent transfer surface is in the surface of tissue regions.
215, according to each described device in the claim 204 to 214, also comprise:
D) cooling package is used at least a portion of cools tissue.
216, according to the described device of claim 215, wherein said cooling package is selected from the group that is made of contact cooling package and spray cooling assembly.
217, basically according to the one or more aspects of device that are used to destroy hair follicle of above-mentioned arbitrary characteristics or combination of features.
218, basically according to the one or more aspects of method that are used to destroy hair follicle of above-mentioned arbitrary characteristics or combination of features.
CN200780010851.2A 2006-03-03 2007-03-04 Method and apparatus for light-based hair removal Active CN101553279B (en)

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US77840306P 2006-03-03 2006-03-03
US60/778,403 2006-03-03
US85342806P 2006-10-23 2006-10-23
US60/853,428 2006-10-23
PCT/IL2007/000274 WO2007099545A2 (en) 2006-03-03 2007-03-04 Method and apparatus for light-based hair removal

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CN106178286A (en) * 2016-08-25 2016-12-07 山东杰美医疗科技有限公司 Intelligent Recognition multi-wavelength, the high-power semiconductor laser depilation system treating head more
CN109603013A (en) * 2018-11-23 2019-04-12 北京镭特医疗科技有限公司 A kind of multifunctional combination beauty instrument and its working method

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