CN101496579B - Special diet and foodstuffs formula containing small peptide for tumor patient - Google Patents
Special diet and foodstuffs formula containing small peptide for tumor patient Download PDFInfo
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- CN101496579B CN101496579B CN200810006608XA CN200810006608A CN101496579B CN 101496579 B CN101496579 B CN 101496579B CN 200810006608X A CN200810006608X A CN 200810006608XA CN 200810006608 A CN200810006608 A CN 200810006608A CN 101496579 B CN101496579 B CN 101496579B
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Abstract
The invention provides a formulation for a special prandial food, which contains short peptides and is provided for tumor sufferers to eat. The food uses food-originated short peptides as raw materials which are added with extracts of medical-edible Chinese herbal medicines such as champignons, dried orange peels, Chinese wolfberry, yams, tuckahoes, rhizoma polygonati, and the like, and compound complex formulation. With the food formulation, powdered or granular foods can be prepared and are dissolved with warm water to eat. The food prepared according to the formulation is easy to dissolve, can be absorbed and utilized quickly, provides a high quality nitrogen source for organisms, supplements various vitamins and minerals necessary for a human body, can correct the negative nitrogen balance of the tumor sufferers, improve the nutritional status of the tumor sufferers, and can play a role in improving organism immunity and suppressing and resisting cancers through the combined action of various factors such as bioactive components, the functional oligosaccharides, and the like in the food-originated short peptides and the extracts of the medical-edible Chinese herbal medicines, thus the food is suitable for the tumor sufferers, particularly for cancer patients who receive radiation therapy and chemotherapy to eat.
Description
Technical field:
The present invention relates to a kind of food formula, especially relate to and a kind ofly can replenish the needed by human nutrient, improve the body nutrition condition, and utilize the function factor in the medicine-food two-purpose Chinese herbal medicine to regulate body function, be fit to the edible food formula of special diet that contains small peptide of tumor patient.
Background technology:
Along with the change of Chinese economic development and national meals pattern, great change has taken place in China resident's health status and spectrum of disease.2002 the 4th time national residents ' health status investigation result shows that the incidence of disease of China's cancer was obvious ascendant trend than 1992.Because the multiple factors such as side effect of intestines and stomach mechanicalness factor, operation, chemotherapy and/or radiotherapy that apocleisis, tumour are relevant, nearly 50% cancer patient is arranged with carcinous dyscrasia syndrome, and can cause life-threatening malnutrition.
The cancer patient is given replenishing of nutrient such as proteins,vitamins,minerals, help improving and correcting the carcinous dyscrasia of tumor patient.Adopt the mode of parenteral nutrition (promptly importing nutritional drugs) that the cancer patient is carried out nutritional supplementation clinically more.Easily cause enteron aisle Villus atrophy, accompanying infection and long-term parenteral nutrition is additional, increase the weight of harm body.Therefore, clinical nutrition educational circles is consistent both at home and abroad thinks, prepares the food of special nutrients that is easy to digest and assimilate, and by approach in the intestines cancer patient is carried out nutritional supplementation, is a kind of suitable more method.
For food of special nutrients, corresponding regulation and Application and Development are all arranged in developed countries such as the U.S., European Union.China is with food of special nutrients called after " food for special foods ", and " the packing food for special foods label general rule in advance " of China (GB13432-2004) in regulation, food for special foods is for satisfying the physiological requirements of some special population, or some disease patient's nutritional need, press special formulation and the food of special processing.
Protein is the nutrient of needed by human.Cancer patient is carried out protein to be supplemented with to be beneficial to and to keep its positive nitrogen equilibrium.But because cancer patient's anabolism slows down, catabolism is accelerated, simultaneously, the cancer patient anorexia, the ability of digesting and assimilating of stomach and intestine weakens, and complete protein is difficult for being utilized.The development of nutrition science and Food Science has utilized biological enzymolysis technology to develop small peptide class material.Small peptide is a small molecule protein, can directly absorb without digestion in intestines and stomach, and the protein that is particularly suitable for cancer patient that the digestion absorbability is weakened is additional.
Chinese herbal medicine is the treasure of China's traditional chinese medicine.Because of the characteristic of its integration of drinking and medicinal herbs is widely used all the time.Modern nutriology and pharmaceutical research are verified, contain physiologically active ingredients such as active polysaccharide class, saponins, phenols in the medicine-food two-purpose Chinese herbal medicine body physiological function is had important regulatory role.Health ministry has been issued " be food be again the article list (defending the method prison sends out [2002] No. 51) of medicine " in 2002, for the application of traditional Chinese herbal medicine in food provides reliable basis.
At present, have on the market and utilize food source property small peptide to carry out the food that protein replenishes, also can find cancer therapy drug with herbal development.But do not find that also that utilizes that food source property bioactive peptide, medicine-food two-purpose Chinese herbal medicine extract make can carry out food for special foods or the similar products that protein replenishes and body function is regulated to tumor patient.
Summary of the invention:
The objective of the invention is physilogical characteristics, metabolic characteristics and nutritional need, provide a kind of and will eat the food formula of special diet that property small peptide in source combines with the medicine-food two-purpose Chinese herbal medicine extract at tumor patient.This food formula of special diet is that body provides the high-quality nitrogenous source with food source property small peptide, the multivitamin and the mineral matter that contain needed by human body, regulate body physiological function by the function factor in food source property small peptide, the medicine-food two-purpose Chinese herbal medicine extract, compound sugar etc., can assist improve immunity of organisms, anticancer, keep the body function of intestinal canal, edible back does not produce toxic and side effect to human body.It is edible that the food that the present invention proposes is fit to tumor patient, especially accepts the patient of radiotherapy/chemotherapy.
The food for special foods that the present invention proposes is to be primary raw material with the small peptide, adds traditional medicine-food two-purpose Chinese herbal medicine extract, functional oligose, vitamin, mineral matter again, the compound prescription that is combined into.
The main component of the present invention's prescription is:
Small peptide:
Small peptide of the present invention is oligopeptide, is meant the small molecule protein that utilizes bio-enzyme engineering technology separation and Extraction from animal or vegetable protein.Its mean molecule quantity is below 1000Dalton, and is soluble in water, to acid, thermally-stabilised, can not need directly absorb through digestion, the bioavailability height, amino acid that is better than dissociating in absorption and utilization and complete protein can be applicable in the protein supplement.Especially for the low crowd of the ability of digesting and assimilating, small peptide is splendid nitrogenous source.
Except that trophic function, small peptide also has a series of physiological active functions:
1. improve the digestion and absorption function of small intestine.Small peptide can improve mucous membrane of small intestine tissue morphology structure, increases the height and the surface area of intestinal villi, deepens the degree of depth of crypts, improves and keep the integrality of intestines wall mucomembranous cell 26S Proteasome Structure and Function, has material impact for the ability of digesting and assimilating that improves small intestine.
2. enhancing immunity of organisms.Small peptide can increase the phagocytic rate and the phagocytic index of macrophage, strengthens lymphocytic multiplication capacity, and enhancing antibody forms the increase of cell quantity, improves the immunity of organism level.
3. anti-oxidant.Small peptide can increase the activity of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), catalase (CAT), reduces the level of MDA MDA (MAD), the performance antioxidation.
4. auxiliary adjustment blood sugar.Zoopery shows that small peptide has the trend that reduces the diabetes rat fasting blood glucose level, and the fasting blood glucose level of normal rat is not had obvious influence.
5. auxiliary adjustment of blood fat.Small peptide can reduce the level of serum total cholesterol and LDL-C.
6. aided blood pressure-lowering.
7. radioresistance.Small peptide helps to keep the integrality of body Skin Cell 26S Proteasome Structure and Function, alleviates radiation injury.
8. promote that mineral matter absorbs.Small peptide in enteron aisle by with mineral matter chelatings such as calcium, iron, zinc, improve the transhipment ratio of mineral matter, increase the absorptivity of mineral matter.
9. strengthen the action effect of function factor in the medicine-food two-purpose Chinese herbal medicine.Function factor in small peptide and the Chinese herbal medicine such as active polysaccharide etc. have synergy, can improve it and strengthen immunity of organisms, radiation-resistant effect.
Small peptide of the present invention is meant marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, wherein a kind of, several or whole mixing of ovalbumin peptide.
Marine collagen peptide of the present invention is meant that the fish-skin with deep-sea fish (as salmon etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Sea bone peptide of the present invention is meant that the fish-bone with deep-sea fish (as cod, anglerfish etc.) is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
It is raw material that Soyprotein peptide of the present invention is meant with the soybean protein, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Whey protein peptide of the present invention is meant that the lactalbumin with cow's milk is a raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
Ovalbumin peptide of the present invention is meant that with egg protein (as egg albumen) be raw material, utilizes biological enzymolysis technology, the small protein of extraction, and its mean molecule quantity is lower than 1000Dalton.
The medicine-food two-purpose Chinese herbal medicine extract:
Shitake Mushroom P.E:
Mushroom is China resident's a food commonly used.The traditional Chinese medical science is thought, mushroom is flat, flavor is sweet, nontoxic, goes into stomach warp, Liver Channel, has beneficial gas qi-restoratives, effects such as strengthening the spleen and stomach are suitable for getting old and weak, illness patients such as weakness due to chronic disease, weakness of the spleen and the stomach, poor appetite, shortness of breath and fatigue, constipation, anaemia, tumour are as auxiliary dietotherapy.
Contain multiple bioactive ingredients in the Shitake Mushroom P.E, can help body to press down knurl, anticancer.Lentinan can be regulated the T of immunologic function cytoactive in the human body, can increase the cellular immunity and the humoral immune function of body, has the effect that suppresses tumour.In the mushroom 1, the 3-glucuroide can improve the ability that body suppresses the cancer knurl, kills cancer cell indirectly, stops the cancer cell diffusion.
Dried orange peel extracts:
Dried orange peel nature and flavor suffering, hardship, temperature are gone into spleen, lung channel, have regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect, are used for the lung of retention of damp leading to blockage of QI phlegm due to coagulating and lose that a surname is respectful, the card of the dysfunction of the spleen in transport, help improving the spleen and stomach function of tumor patient.Modern clinical pharmacodynamic experiment shows that the polymethoxy flavone compound of peculiar multiple low polarity part possesses certain antitumor activity in the dried orange peel, and dried orange peel extracts has the effect that impels cancer cell-apoptosis.
Fructus lycii P.E:
The fruit of Chinese wolfberry is that former, the antidotal medicine-food two-purpose article of training are reinforced the kidney, consolidated to strong essence.It is sweet to distinguish the flavor of, and property is flat, returns liver, kidney channel, and the fruit of Chinese wolfberry has filling liver kidney, makes eye bright, the effect of moistening lung.
According to modern medicine study, the fruit of Chinese wolfberry contains the nutritional labeling and the bioactive ingredients of multiple needed by human.The acetone that extracts from the fruit of Chinese wolfberry can stop gene mutation.LBP-X has very strong antioxidation activity, can elevating blood in the content of superoxide dismutase (SOD), can strong cell membrane, to the attack of Green Tea Extract, and then can promote intercellular material Transfer and transhipment.LBP-X has the enhancing body immunity, resists growth of cancer cells, can also promote the decline of cancer cell.
Yam extract:
Chinese yam is strengtheninged the spleen and tonifying the lung, and the benefit of reinforcing the kidney is smart, and hearing-improing and eyesight improving helps the five internal organs, strengthening the bones and muscles, and long will is calmed the nerves, and promotes longevity.Tonifying spleen nourishing the stomach, the beneficial lung that promotes the production of body fluid, the puckery essence of kidney tonifying.Contain the amino acid of multiple necessary for human, abundant vitamin and various trace elements in the Chinese yam, Chinese yam also contains multiple bioactive ingredients, as Chinese yam polysaccharide, saponin, mucus protein, choline, protamine, amino acid, polyphenol oxidase etc., be of value to the recovery of kidney and allomeric function.
Tuckahoe extracts:
The effect that Poria cocos has invigorating the spleen dehumidifying, antitoxic heart-soothing and sedative, brain healthy, invigorates the kidney and stops nocturnal emission.Contain the nutritional labeling such as vitamin, mineral matter of multiple needed by human in the tuckahoe extracts, also contain the polysaccharide material that a large amount of human bodies very easily absorb, can strengthen the immunologic function of human body, helpful per capita to patients on long-term, weakling and old age.Wherein some composition such as β-pachymaran have inhibitory action to cancer cell, take for a long time to promote cancer patient's chemotherapy, postoperative rehabilitation.
Rhizoma Polygonati extract:
Sealwort is flat, flavor is sweet, can the tonifying spleen moistening lung, and supplementing qi and nourishing yin, strengthening the bones and muscles has good improvement effect to diseases such as weakness of the spleen and the stomach, fatigue and asthenias.Contain multiple compositions such as Siberian solomonseal rhizome polysaccharide, steroid saponin, flavones, anthraquinone analog compound in the sealwort.Coarse solomon's seal polysaccharide has the effect of moderate immune stimulating to human peripheral lymphocytes, and immunologic hypofunction patient's lymphocyte is had the height excitation.
Siberian solomonseal rhizome polysaccharide can obviously resist
60The minimizing of Co ray induced mice PBL and total number of blood platelet strengthens NK and CTL activity, shows its radioresistance, antineoplastic action.
Medicine-food two-purpose Chinese herbal medicine extract of the present invention is a kind of, several or whole mixing wherein of Shitake Mushroom P.E, dried orange peel extracts, Fructus lycii P.E, yam extract, tuckahoe extracts, Rhizoma Polygonati extract.
Mushroom, dried orange peel are China resident's common food, and the fruit of Chinese wolfberry, Chinese yam, Poria cocos, sealwort are the article of " be food be again medicine " of health ministry approval.Adopt its extract in the present invention's prescription, improved the concentration of function factor, reduce the harm of impurity.
Shitake Mushroom P.E of the present invention, it is concentrated to be that Pleurotaceae fungi plant mushroom fruiting body is carried through water, the spray-dried again and flour of preparation.
Dried orange peel extracts of the present invention, be meant dried orange peel water is carried concentrated, spray-dried again and the preparation flour.
Fructus lycii P.E of the present invention, be meant fruit of Chinese wolfberry water is carried concentrated, spray-dried again and the preparation flour.
Yam extract of the present invention, be meant Chinese yam water is carried concentrated, spray-dried again and the preparation flour.
Tuckahoe extracts of the present invention, be meant Poria cocos water is carried concentrated, spray-dried again and the preparation flour.
Rhizoma Polygonati extract of the present invention, be meant sealwort water is carried concentrated, spray-dried again and the preparation flour.
Compound sugar:
Compound sugar claims oligosaccharides again, is meant the low polymerization sugar of the straight or branched that is connected to form by glycosidic bond by 2～10 monose.Functional oligose is not absorbed by human consumption, do not utilized by most enteron aisle spoilage organisms yet, but can promote beneficial bacteria---the growth and breeding of lactobacillus, Bifidobacterium in the human body, thereby can suppress the spoilage organisms growth, help to improve and keep the enteron aisle normal function.Long-term edible can delay senility, defaecation, raising immunity, alleviate burden of liver, improve the absorptivity of nutrient, particularly can improve the absorption of body metal ions such as calcium, iron, zinc.
Compound sugar of the present invention is a kind of, several or whole mixing wherein of oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide.
Vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human.The vitamin that adds among the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin C, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, nicotinic acid, folic acid, pantothenic acid, choline, biotin a kind of, several or whole mixing wherein.
The mineral matter that adds among the present invention is a kind of, several or whole mixing wherein of calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum.Mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter.
The addition of vitamin and minerals (GB14880-1994) is carried out with reference to " DRIs " and " food enrichment use sanitary standard " of Chinese Soclety of Nutrition's promulgation in 2000 among the present invention.
Above-mentioned various batch mixes is even, can keep its powdery, or through granulation, makes powdery or granule state food.
Technological merit of the present invention:
The present invention combines the health care theory that modern biotechnology achievement in research, modern nutriology are theoretical and China is traditional, has developed a kind of short peptide type food of special nutrients that adopts mixed preparing such as food source inhibition biological active small peptide, medicine-food two-purpose Chinese herbal medicine extract, compound sugar, vitamin and mineral matter.By the organic assembling of various batchings, various functions are merged, and by the synergy between the active ingredient, humidification effect.Can effectively replenish the tumor patient desired nutritional by the present invention's food of making of filling a prescription, improve the nutrition condition of tumor patient, simultaneously, can strengthen the resistance of tumor patient, help to realize but cancer, anticancer effect.
The characteristic of this formula food and the effect of body mainly shown the following aspects:
1) has efficient absorption
Utilize prescription of the present invention, various components adopt the food of suitable ratio collocation preparation, the state that oozes such as are after a certain amount of water-soluble separating, can arrive small intestine by stomach fast, absorb fast, fully, can replenish the tumor patient desired nutritional rapidly, do not increase liver kidney burden.
2) trophism
Formula food of the present invention is a nitrogenous source with the food source inhibition biological active small peptide in multiple source.Because small peptide need not digest and can absorb, more help the utilization of body, can effectively improve the tumor patient negative nitrogen balance.
Formula food of the present invention contains multivitamin and mineral matter, can replenish the required micronutrient of tumor patient rapidly.Small peptide by with the chelating of calcium, iron, zinc etc. after, more increased the absorptivity of mineral matter element.
3) improve immunity of organisms, strengthens anticancer, but the cancer ability
Contain multiple functional active components in the medicine-food two-purpose Chinese herbal medicine extract in the formula food of the present invention, has the effect that strengthens resistance of human body, food source property small peptide can improve the immunity of organism level, compound sugar also can strengthen immunity of organisms by the growth and breeding that promotes beneficial bacteria of intestinal tract, and bioactivators such as small peptide and active polysaccharide have synergy.The effect of multiple factor is combined, and more helps strengthening the resistivity of body, the effect that reach anticancer, presses down cancer.
4) improve gastrointestinal function
Food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.Compound sugar suppresses the growth of spoilage organisms by promoting the growth and breeding of probio in the intestines, forms on the intestinal mucosa surface simultaneously and protects barrier together, can resist the damage of enteron aisle spoilage organisms to intestinal mucosa, reduces the absorption of intestinal toxic material.Compound sugar can promote intestines peristalsis, quickens the discharge of residuals in the intestines, can prevent constipation.
5) not fatty and cholesterol in the present invention's prescription can not increase the absorption of fat, cholesterol in additional protein, micronutrient, has avoided the adverse effect of high protein foods such as meat, egg.
6) strengthen anti-oxidant, the capability of resistance to radiation etc. of body.
7) adopt the extract of various medicine-food two-purpose Chinese herbal medicines during the present invention fills a prescription, improved the concentration of function factor, reduce the absorption of various impurity, help to alleviate liver kidney burden.
The specific embodiment:
The invention will be further described by the following examples.
Embodiment 1 preparation is for the edible short peptide type food for special foods (powdery) of tumor patient
Present embodiment is selected marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide, Shitake Mushroom P.E, dried orange peel extracts, Fructus lycii P.E, tuckahoe extracts, yam extract, isomalto-oligosaccharide and the various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 3.0g sea bone peptide 0.5g Soyprotein peptide 1.0g whey protein peptide 1.0g ovum is from protein peptides 0.5g
Shitake Mushroom P.E 0.5g dried orange peel extracts 0.5g Fructus lycii P.E 0.5g tuckahoe extracts 0.3g yam extract 0.2g
Isomalto-oligosaccharide 2.0g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid lmg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg.
Above-mentioned raw materials is mixed, stir,, make powdered food through super-dry.After about 150ml temperature dissolved in boiled water, directly drink or take in through nasal feeding.
Embodiment 2 preparations are for the edible short peptide type food for special foods (graininess) of tumor patient
Present embodiment is selected marine collagen peptide, sea bone peptide, whey protein peptide, Shitake Mushroom P.E, dried orange peel extracts, xylo-oligosaccharide and the various vitamin and the mineral matter of powdery, fills a prescription by following raw material and consumption thereof.
Marine collagen peptide 3.5g Soyprotein peptide 1.5g whey protein peptide 1.0g
Shitake Mushroom P.E 1.0g dried orange peel extracts 1.0g
Xylo-oligosaccharide 0.5g
Vitamin A 0.2mg, vitamin E 3mg, vitamin C 30mg, Cobastab
10.5mg, Cobastab
20.5mg, Cobastab
60.5mg, Cobastab
120.5mg, nicotinic acid 0.5mg, folic acid 0.1mg, pantothenic acid 1mg, choline 50mg
Calcium 200mg, potassium 100mg, magnesium 100, iron 5mg, zinc 5mg, selenium 0.01mg, manganese 1mg.
Above-mentioned raw materials is mixed, stir, through granulation, drying, whole grain is made granule state food.After about 150ml temperature dissolved in boiled water, directly drink or take in through nasal feeding.
Claims (6)
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Address after: 100015 Beijing, Jiuxianqiao Middle Road, building 24, No., building 6 Patentee after: China National Academy of Food & Fermentation Industries Patentee after: Sino Peptide (Beijing) Healthy Technology Co., Ltd. Address before: 100027 Beijing city Chaoyang District Xiaoyun Road No. 32 Patentee before: China National Academy of Food & Fermentation Industries Patentee before: Sino Peptide (Beijing) Healthy Technology Co., Ltd. |
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Effective date of registration: 20160927 Address after: 523122 Guangdong Province, Dongguan city Dongcheng District science and Technology Industrial Park Tong Road No. 6 Patentee after: GUANGDONG ZHONGSHI YINGKE BIOTECHNOLOGY CO., LTD. Address before: 100015 Beijing, Jiuxianqiao Middle Road, building 24, No., building 6 Patentee before: China National Academy of Food & Fermentation Industries Patentee before: Sino Peptide (Beijing) Healthy Technology Co., Ltd. |