CN101489608B - Medical delivery system with asymmetrical coding means - Google Patents

Abstract

A dosing assembly (204) and/or a container (202) comprises fastening means (206,208) for fastening the container to the dosing assembly, the fastening means of the dosing assembly and/or the container define an asymmetrical pattern in a plane transverse to an axial direction of the dosing assembly and/or a container.

Description

Medical delivery system with asymmetric coding device

technical field

The invention relates to a medical delivery system comprising a container for containing a medicament and a dosing assembly adapted to be secured to the container. In particular, the invention relates to first fastening means of the dosing assembly and/or second fastening means of the container, said first fastening means and said second fastening means being in a plane perpendicular to the axial direction of the device An asymmetric pattern is defined in . Furthermore, the invention relates to a container and a dosing assembly, each of which is suitable for use in a medical delivery system according to the invention.

Background technique

In general, a greater variety of drug delivery systems has been introduced in the interest of patients in order to provide a superior drug delivery device that is likely to be well accepted by a particular patient group. As the number of commercially available delivery systems has increased, many different types of drug retention cartridges or containers have spread. Most of these types of containers differ in a number of ways.

Each medicament container can be filled with a particular medicament type selected from a number of different medicaments, and different classes of the same medicament (eg rapid or long-acting insulin) as well as different concentrations of each particular medicament can be contained in the container.

In addition, different container volumes can be introduced to tailor each container and thus the delivery system to the needs of a particular user. Variations in container volume can be achieved by changing the length or diameter of the container. These modifications generally mean corresponding modifications of the dosing components of the dosing system in order to provide a specific stroke of the drive element for ejecting the medicament from the container or to provide an optimum dosing accuracy. Furthermore differences between different medicament containers may result from the design requirements of each particular delivery system, such as the required sliding friction of the piston contained in the container.

In order to differentiate between the wider variety of containers available, a number of container coding systems have been developed that rely primarily on electronic reading and identification of specific containers in order to allow specific types of medicament to be delivered by specialized delivery devices. In the prior art, the following mechanical coding systems are known:

US 5611783 relates to a pen-shaped injector comprising a distal part, which may contain an ampoule, and a proximal part, which contains a dose setting and drive mechanism. The proximal and distal sections have interlocking bayonet couplings. The protrusions may be arranged to form a pattern that ensures that a particular distal portion can only be used in conjunction with a particular proximal portion.

WO 03/017915 A1 discloses a cartridge having a distal end provided with a mechanical coding. This mechanical coding is in the form of a circular protrusion with a circular outer diameter dedicated to a particular concentration of insulin contained in the cartridge.

US 5693027 discloses a plastic cap for adapting a standard barrel to a selected syringe. The plastic cap may be provided with means for keyed engagement with corresponding means in the syringe to hold the plastic cap against rotation when the barrel is mounted in the syringe. In some types of syringes, this keyed engagement between the barrel and the syringe also serves to ensure that only certain types of barrels are used.

US 6648859 B2 discloses a cartridge assembly for use with a reusable pen body assembly of a drug delivery pen. To avoid cross-use, the pen body assembly and cartridge are locked, i.e. they can be threadedly engaged by corresponding threads and grooves, bayonet threads and grooves, mating or a pair of lugs that mate in a reverse Luer-Lock fashion . Mating components are chosen to prevent cross-use with other components, eg the pitch of the threads may be angled so as to only mate with each other and not with other components.

Another prior art system is disclosed in DE 20110690.

The purpose of the preferred embodiments of the present invention is to provide an alternative to known systems. Furthermore, it is an object of preferred embodiments of the present invention to provide drug delivery systems with a large number of possible encoding geometries.

Furthermore, it is an object of preferred embodiments of the present invention to provide a coding system in which the user experiences substantially the same operative fastening motion when coupling/detaching the container and dosing assembly of a predetermined medical delivery system from each other, as in compatible The specific selection in the group of containers and quantitative components is irrelevant. Furthermore, it is an object of the preferred embodiments of the present invention to provide such a system with a large number of different coded container/dosing assemblies while obtaining a durable system which minimizes the possibility of mechanical failure.

Furthermore, it is an object of preferred embodiments of the present invention to provide an intuitive fastening mechanism for fastening a container to a dosing assembly.

Contents of the invention

In a first aspect, the invention relates to a medical delivery system comprising:

a container adapted to contain a medicament in a chamber defined by the container and a slidably disposed piston movable in a distal direction towards the outlet to reduce the volume of the chamber and eject the medicament through the outlet;

a dosing assembly adapted to be fastened to the container so as to allow the driver of the dosing assembly to move the piston of the container in a distal direction;

Wherein the dosing assembly defines first fastening means, which engages with second fastening means of the container during fastening of the container to the dosing assembly, whereby the container is passed by the first and second fastening means Fastened to the dosing assembly for at least one defined predetermined movement of less than one revolution;

Wherein the side wall of one of the first and second fastening means defines at least two protrusions extending in a radial direction, each of said at least two protrusions being adapted to be defined in the first and second fastening means engages with a corresponding groove in the sidewall of the other of the devices; and

Wherein at least one of the first and second fastening means defines an asymmetric pattern in a plane perpendicular to the axial direction of the device.

The medical system according to the invention increases user safety since only predetermined containers can be attached to the dosing assembly. Thus, the dosing assembly may be designated for use with a predetermined type and/or concentration of medicament, whereby containers containing other concentrations or types of medicament cannot be attached to the dosing assembly.

In the context of the present invention, the term "medical delivery system" is to be understood as any system capable of administering a flowable pharmaceutical containing a medicament. Examples of medical delivery systems are infusion pump applications, dosers, pen dosers, motor dosers, and automated injectors such as the Automatic Pen(TM).

The invention is applicable to a variety of drug delivery devices capable of delivering a medicament to a user from a container adapted to be coupled to a dosing assembly of the delivery device. The delivery device may include any delivery device for transdermal, subcutaneous, intravenous, intramuscular or pulmonary administration of a drug.

As used herein, the term "medicament" is meant to include any flowable pharmaceutical product containing a medicament, such as a liquid, solution, gel or microsuspension, capable of being passed in a controlled manner through a delivery device such as a hollow needle. Typical agents include pharmaceuticals such as peptides, proteins (e.g., insulin, insulin analogs, and C-peptides) and hormones, biologically derived agents or agents, hormone and gene-based agents, nutritional formulations, and Other substances in solid (delivery) or liquid form.

The chamber of the container may be defined by one or more side walls of the container and a slidably disposed piston. In most embodiments, at least a portion of the container is annular and defines a cylindrical cavity that receives the piston. The distal end of the container may comprise a seal for being pierced by the cannula to allow the medicament contained in the chamber to be ejected through the cannula. The distal end of the container may be adapted for attachment to a holder holding the sleeve. As an example, the distal end of the container may include threads adapted to mate with corresponding threads of the holder so that the holder can be screwed onto the container.

The outlet of the container may be adapted to cooperate with or be defined by a cannula or needle or needle hub or infusion set or any other flow conduit such as by A cannula or needle is defined, adapted to provide fluid access to the medicament contained in the container.

The driver of the dosing assembly may comprise a piston rod adapted to move the piston in the distal direction. The piston rod may comprise a member that is stiffer than the piston and adapted to abut at least a portion, and preferably a substantial portion, of the proximally facing surface of the piston, whereby the direction of the rigid member is increased by the piston rod as compared to the direct engagement of the piston rod with the piston. The applied force is applied to a larger area of the proximal face of the piston.

The dosing assembly defines first fastening means which engage second fastening means of the container during fastening of the container to the dosing assembly. In one embodiment, the proximal facing surface of the first fastening means of the dosing assembly engages the distal facing surface of the second fastening means of the container.

The container may be secured to the dosing assembly by a predetermined movement comprising at least parallel axial and rotational movement, such as a screw movement. The rotational movement induced by the parallel axial and rotational movement is less than one revolution, such as less than 120 degrees, such as less than 90 degrees, such as less than 60 degrees. Rotation of the container relative to the dosing assembly causes the container and the dosing assembly to be drawn towards each other when the proximal facing surface of the first fastening means and the distal facing surface of the second fastening means come into engagement.

In a first embodiment, the first fastening means of the dosing assembly defines a recess adapted to receive the protrusion defined by the second fastening means of the container. During fastening of the container to the dosing assembly, the generally proximally facing surface of the first fastening means of the dosing assembly engages the generally distally facing surface of the container. The predetermined movement is defined by the shape of at least one of the joint surfaces. In yet another embodiment, the second fastening means defines a plurality of protrusions, such as two, three or four, and the first fastening means defines a plurality of corresponding grooves adapted to engage with the protrusions.

In a second embodiment, the recess is defined by the container and the protrusion is defined by the dosing assembly. In a third embodiment, the container defines a combination of grooves and protrusions adapted to engage corresponding protrusions and grooves defined by the dosing assembly.

In the context of the present invention, the term "asymmetrical pattern" is to be understood such that when the first and second fastening means define an asymmetrical pattern, there is only one relative rotational position between the dosing assembly and the container, wherein the first The fastening means may be housed in/received by the second fastening means, thereby enabling fastening of the container to the dosing assembly. The relative rotational positions of the container and dosing assembly are relative to the longitudinal axis of the device.

In one embodiment, the cross section may be at right angles to the axial direction of the device, ie define an angle of 90 degrees with respect to the axial direction of the device.

The pattern may be defined by at least two protrusions and/or at least two grooves, whereby a plane may extend through all at least two protrusions and/or all at least two grooves.

In one embodiment, the first and second fastening means define an asymmetrical pattern in a plane perpendicular to the axial direction of the device. In such embodiments, the cross-sectional patterns of the first and second fastening means may be substantially the same.

In one embodiment, at least one of the first and second fastening means defines less than two lines of symmetry, such as one line of symmetry, in a plane perpendicular to the axial direction of the device. In a particular embodiment, the first and/or second fastening means define a single line of symmetry extending through the groove or protrusion of the first or second fastening means.

Furthermore, at least one of the first and second fastening means may not define a line of symmetry in a plane perpendicular to the axial direction of the device.

In another embodiment, each of the at least two protrusions or grooves defines a center point, the angle between any two center points about the longitudinal axis of the device being different than 180 degrees. The center point of the protrusion may be defined as the center of inertia of the protrusion itself, ie regardless of the area of the remainder of the cross-section. Additionally, the center point of the groove can be defined as the inertial center of the mass/area removed to define the groove. Therefore, in this embodiment, any two protrusions/grooves are not disposed exactly opposite to each other on the inner or outer surface of the dosing assembly.

Furthermore, the circumferential extent of two or more of the at least two protrusions or grooves may differ. By circumferential extent is meant the length of the protrusion/recess along the circumference of the dosing assembly or container. In one embodiment, the circumferential extent of the first protrusion is 50%, such as 100%, such as 150%, greater than the circumferential extent of the second protrusion. Also, a first of the at least two protrusions or grooves may define a different shape than a second of the at least two protrusions or grooves.

In one embodiment, one or more of the at least two protrusions or grooves may define an inclined surface such as with respect to the axial direction of the device. The inclined plane may define a plane perpendicular to the longitudinal direction of the device and extending at an angle different from 90 degrees relative to said longitudinal axis.

The medical delivery system may include an axially extending coding mechanism defined by a proximal face of the container and a corresponding distal face of the dosing assembly, the proximal face of the container defining one or more axially extending protrusions and/or Notches, during the fastening of the container and the dosing assembly, the protrusions and/or notches cooperate with the matching one or more protrusions and/or notches of the far-facing coding surface of the dosing assembly, whereby if the far and Said predetermined movement is prevented if each of the proximally facing surfaces does not define one or more predetermined protrusions and/or indentations selected from a predetermined group of protrusions and/or indentations. The proximal surface may be a proximal surface. The distal surface may be a distal surface. In one embodiment, the end face may be annular.

In the context of the present invention, the terms "groove" and "protrusion" are only used in connection with the first and second fastening means, while "indentation" and "protrusion" are only used in connection with the axially extending coding means. However, "groove" and "notch" shall be considered synonyms, and "protrusion" and "protrusion" shall be considered synonyms.

The axially extending coding mechanism can be defined by the circumferential position of the protrusion/notch and/or the axial extent of the protrusion/notch and/or the radial extent of the protrusion/notch and/or the circumferential extent of the protrusion/notch . In one embodiment, at least one of circumferential position, axial, radial and circumferential extent is used to specify a first characteristic of the medicament, while the remaining ones of circumferential position, axial, radial and circumferential extent are At least one second characteristic for specifying the medicament.

As an example, the location of the notch can be used to specify the type of agent, while at least one of the radial, axial and circumferential extent can be used to specify the concentration of the agent.

Accordingly, it will be appreciated that a medical delivery system according to the present invention provides a plurality of encoded geometries, each of which may be used to specify a different characteristic. As an example, the first and second fastening means may be used to designate a first predetermined characteristic of the medicament, such as the type of medicament, while the axially extending coding mechanism may be used to designate a second predetermined characteristic of the medicament, such as the concentration of the medicament. Other examples of features that can be specified by coded geometry are: Male/Female Drugs; Pediatric/Adult Drugs; Preventive/Therapeutic Drugs, Slow/Fast Acting Drugs.

In one embodiment, the container comprises at least two protrusions, such as two, three or four, extending from the proximal face of the container, and the dosing assembly comprises at least two protrusions adapted to cooperate with said at least two protrusions. Compatible notches, such as two, three or four.

At least a portion of said predetermined movement may be parallel axial and rotational movement. In one embodiment, the predetermined movement defines a substantially pure axial movement followed by a combined parallel axial and rotational movement. This substantially pure axial movement can be used to indicate to the user that the lug and groove are mating, whereby it prevents the user from performing the combined movement with a force that would cause damage to either the groove or the lug.

Alternatively, or in addition, the predetermined movement defines a combined parallel axial and rotational movement followed by a substantially pure rotational movement. This substantially pure rotational movement can be used to indicate to the user that the container and dosing assembly are actually secured to each other.

The first/second fastening means and/or the axially extending coding mechanism may be adapted to prevent at least part of the axial and/or rotational movement of the intended movement in order to prevent coupling of the container with the dosing assembly. When the container cannot be coupled to the dosing assembly, the dosing assembly cannot be used to eject the medicament.

In one embodiment, the container comprises a cartridge holder and a cartridge defining said chamber. The second fastening means may be defined by the cartridge holder or may be attachable to the cartridge holder. Also, notches/protrusions and/or protrusions/grooves may be defined by the cartridge holder. The cartridge and cartridge holder may be two separate elements, with the cartridge frictionally retained in the cartridge holder. In one embodiment, the cartridge is made of glass and the cartridge holder is made of a non-glass material to protect the glass cartridge. The cartridge is not detachably held in the cartridge holder so that if the cartridge is detached from the cartridge holder it cannot be reattached by hand without tools. This provides the advantage that the cartridge holder cannot be used anymore when the cartridge has become empty, so a cartridge with the wrong medicament cannot be inserted into the cartridge holder and dispensed using the dosing assembly. The cartridge holder and cartridge may define a unitary element, ie form one element without seams. This integral element may be formed as a molding made of a synthetic resin such as Topas(R) or polypropylene. This molded article may include fastening and coding elements formed during moulding. However, any material suitable for long-term storage of the particular drug to be contained in the container may be used.

As noted above, at least a portion of the predetermined movement may be parallel axial and rotational movement. Furthermore, the first and/or second fastening means may be adapted to prevent part of the axial and/or rotational movement of the intended movement, whereby if each of the first and second fastening means does not define a predetermined asymmetrical code geometry, prevents the coupling of the container to the quantitative component. The coded geometry of the first and/or second fastening means may be defined by at least one of the following: the circumferential extent of the first and second fastening means, the axial extent of the first and second fastening means, the The radial extent of the first and second fastening means and the circumferential position of the first and second fastening means.

One embodiment includes:

A first container having any of the aforementioned features and/or elements adapted to be fastened to a first dosing assembly having any of the aforementioned features and/or elements; and

A second container having any of the aforementioned features and/or elements adapted to be fastened to a second dosing assembly having any of the aforementioned features and/or elements; and

At least two of the following:

the first fastening device of the first dosing assembly,

the first fastening device of the second dosing assembly,

the second fastening device of the first container, and

the second fastening means of the second container,

Adapted to prevent the first dosing assembly and the second container from being fastened to each other, and to prevent the second dosing assembly and the first container from being fastened to each other.

Furthermore, the predetermined movements required for coupling and decoupling the first container to the first dosing assembly and for coupling the second container to the second dosing assembly may be substantially the same.

In a second aspect, the invention relates to a container suitable for use in (for a medical delivery system according to the first aspect of the invention) a medical delivery system according to the first aspect of the invention.

It will be appreciated that the invention according to the second aspect may comprise any features and/or elements of the invention according to the first aspect. In particular, the container of the second aspect may comprise any of the features and/or elements of the container according to the first aspect of the invention.

In a third aspect, the invention relates to a dosing assembly suitable for use in (for a medical delivery system according to the first aspect of the invention) a medical delivery system according to the first aspect of the invention.

It will be appreciated that the invention according to the third aspect may comprise any features and/or elements of the invention according to the first aspect. In particular, the dosing assembly of the third aspect may comprise any of the features and/or elements of the dosing assembly according to the first aspect of the invention.

Description of drawings

The invention will now be described in more detail with reference to the accompanying drawings, in which:

Figures 1 and 2 disclose syringe devices known in the prior art,

Figure 3 discloses a medical delivery system according to the invention, and

Figures 4 and 5 disclose containers with two and three protrusions respectively,

Figures 6-12 disclose cross-sections of containers with two, three or four protrusions,

Figures 13a and 13b disclose an embodiment having an axially extending notch which is rotated into engagement with the axially extending protrusion during fastening.

Detailed ways

4”的名字投放欧洲和美国市场。注射器装置100包括近端部102和远端部104。在使用中，近端部102形成剂量设定单元(未示出)的一部分，该剂量设定单元包括延伸通过近端部102的通道(未示出)的活塞杆(未示出)。活塞杆的中心轴线与虚线106重合。在使用中，远端部104限定隔室108，用于容纳含有药剂的贮液器(未示出)。远端部104包括两个脊部110，每个脊部在远端部的每侧，通过将脊部110前移到近端部102的匹配轨道112中，所述脊部用于将远端部104固定到近端部102。所述轨道限定在近端部102的内表面114上。Figures 1 and 2 disclose an injector device 100 which was registered by the applicant under the name "NovoPen" prior to the filing of this application.

4" on the European and American markets. The syringe device 100 comprises a proximal end 102 and a distal end 104. In use, the proximal end 102 forms part of a dose setting unit (not shown) which A piston rod (not shown) comprising a channel (not shown) extending through the proximal end 102. The central axis of the piston rod coincides with the dashed line 106. In use, the distal end 104 defines a compartment 108 for containing Reservoir (not shown) for medicament. The distal portion 104 includes two ridges 110, one on each side of the distal portion, by advancing the ridges 110 to the mating rails 112 of the proximal portion 102. The ridges are used to secure the distal portion 104 to the proximal portion 102. The tracks are defined on the inner surface 114 of the proximal portion 102.

Figure 3 discloses a medical delivery system 200 comprising a container 202 and a dosing assembly 204 (for simplicity only a portion of the dosing assembly is disclosed). The container 202 defines two protrusions 206', 206" adapted to engage mating recesses 208', 208" of the dosing assembly 204. When the protrusions 206', 206" are advanced into the grooves 208', 208", the container and the dosing assembly can rotate, whereby the distance between the far-facing surface 210a of the container and the near-facing surface 212 of the dosing assembly 212 Engagement causes the dosing assembly and container to be drawn toward each other while performing parallel axial and rotational movements. This parallel movement is caused by the inclined proximally facing surface 212 which first engages the distally facing surface 210a and then the distally facing surface 210b.

The medical delivery system comprises three axially extending projections 214 which, in the first embodiment of FIG. A corresponding stop surface (not shown) engages to prevent further rotational movement.

In the second embodiment of FIG. 3 , the protrusion 214 defines a first part of an axially extending encoding mechanism that also includes an axially extending notch (not shown) provided in the dosing assembly.

The protrusions 206', 206" include two inclined surfaces 218 which prevent inadvertent engagement between the protrusions and the grooves, for example in the case of a patient attempting to fasten the container to a dosing assembly to which it cannot be secured. Thus, if the user tilts the container and the dosing assembly (so that their longitudinal axes do not coincide but intersect each other), whereby a protrusion can advance into the groove, relative rotation between the container and the dosing assembly causes The protrusion is forced out of the groove due to the inclined surface 218 .

Figure 4 discloses a cross-section and a front view of a container 202 comprising two protrusions 206', 206" arranged in an asymmetrical pattern in the cross-section of Figure 5 (should it be Figure 4) Disclosed and does not include a line of symmetry. The circumferential extent 205' of the first protrusion 206' is greater than the circumferential extent 205" of the second protrusion 206". Due to the asymmetry, only when the container is arranged in a single The container is only fastened to the matching dosing assembly when it is in the predetermined rotational position.

Figure 5 discloses a cross-section and a front view of a container 202 with three protrusions 206', 206", 206"'. These protrusions do not define a line of symmetry and the circumferential extent of the first protrusion 206' is greater than the circumferential extent of the third protrusion 206"' which in turn is greater than the circumferential extent of the second protrusion 206". the circumferential range of .

Figures 6-8 disclose three containers, each of which includes three protrusions 206', 206", 206"'. In FIG. 6, the angle between any two protrusions (about the central axis 220) is 120 degrees and the protrusions have the same shape. In Fig. 7, the first and second protrusions 206', 206" have the same shape, while the third protrusion 206"' has a different shape than the first and second protrusions. Furthermore, the angle between any two protrusions is also 120 degrees and the container defines a line of symmetry 222 . In the third embodiment, the first protrusion 206' is larger than the second protrusion 206", which is larger than the third protrusion 206"', so that the cross-section does not define a line of symmetry.

The protrusion may define a center point 224 as disclosed with respect to FIG. 8 . A center point may be defined as the center of inertia of the protrusion, and in Fig. 8, about the center axis 220, the angle between any center points is 120 degrees, thus different from 180 degrees.

The container of Figure 9 includes four protrusions 206', 206", 206"', 206"" spaced apart in 90 degree rotation. Furthermore, since the projections have the same shape, the cross-section of the container defines four lines of symmetry 222 . The container of Figure 10 comprises two protrusions 206', 206" and thus defines two lines of symmetry.

In Fig. 11, the container comprises three identical protrusions 206', 206", 206"' and defines a line of symmetry. Also, the single line of symmetry extends through one of the projections. In Fig. 12, the position of one of the protrusions is changed relative to the container of Fig. 11, whereby the container does not define a line of symmetry.

The container 202 of Figure 13a is adapted to be secured to the dosing assembly 204 of Figure 13b by combined rotational and axial movement. The container 202 defines a radially extending protrusion 206 extending from a sidewall 226 of the container 202 and an indentation 228 extending axially from a proximal face 230 into the sidewall 226 in a distal direction. The axially extending notch 228 defines a bottom surface 232 , a stop surface 234 and an inclined surface 236 . Dosing assembly 204 defines a recess 208 for receiving protrusion 206 during fastening of container 202 to dosing assembly 204 . In the embodiment of FIG. 13 b , the groove 208 is defined by a protrusion 238 extending radially outward from the side wall 240 of the dosing assembly 204 and in a direction along the center of the dosing assembly 204 . The inclined surface 236 is shaped to enable the axially extending protrusion 242 of the dosing assembly 204 to move into (and thus be received by) the axially extending notch 228 of the container 202 . Stop surface 234 of notch 228 is adapted to engage with a corresponding stop surface 244 of protrusion 242 of dosing assembly 204 to prevent further relative rotation between container 202 and dosing assembly 204 . The abutment between the two stop surfaces 234 , 244 provides the user with a tactile indication of the fact that the container 202 is secured to the dosing assembly 204 .

The protrusion 238 of the dosing assembly is shaped such that the groove 208 does not define a stop surface, therefore a dosing assembly similar to that of Figure 13b but without the axially extending protrusion 242 will not provide the user with a container 202 secured to this dosing assembly Tactile indication of 204 facts. Thus, the container 202 of FIG. 13a cannot be secured to a dosing assembly 204 that is similar to the dosing assembly of FIG. 13b but does not define the protrusion 242 . This prevents the container 202 from being secured to the dosing assembly 204 in this configuration.

A container similar to that of Figure 13a but not defining an axially extending notch 228 may take two forms. A first form in which the proximal face 230 is defined at the same axial height as the surface 230 in Figure 13a, and a second form in which the proximal face 230 is defined at the same axial height as the bottom face 232 in Figure 13a . The difference between the first and second forms is the distance between surface 230 and protrusion 206 .

Because the proximal face 230 of the container 202 will abut the far-facing surface 246 of the protrusion 242, the protrusion 206 cannot be accommodated in the groove 208 or only partially, i.e. insufficiently, to secure the container 202 to the dosing assembly. 204 moves into the groove 208, so the container 202 of the first form, ie wherein the proximal face 230 is defined at the same axial height as the proximal face 230 of FIG. Quantitative components of 13b.

Because no tactile indication is provided to the user to enable him to determine when the container 202 is fastened to the dosing assembly 204, the second form, wherein the proximal face 230 is defined at the same axial height as the bottom face 232 in FIG. 13 a And a container 202 that does not define an indentation 228 cannot be secured to a dosing assembly 204 that does not define an axially extending protrusion 242, and vice versa. Thus, the user will continue the relative rotation between the container 202 and the dosing assembly 204 whereby the protrusion 206 will move out of the groove 208 so that the container 202 is not secured to the dosing assembly 204 .

From the above it will be appreciated that the embodiment of Figures 13a and 13b increases user safety because a container 202 not intended to be used in conjunction with a predetermined dosing assembly 204 cannot be secured to this dosing assembly 204. Thus, a user is prevented from attaching the container 202 with the wrong medicament or the wrong concentration of the correct medicament to the dosing assembly 204, thereby preventing ejection of such medicament.

Claims (22)

1. A medical delivery system (200) comprising: A container (202) adapted to contain a medicament in a chamber defined by the container (202) and a slidably arranged piston movable along its axis in a distal direction towards the outlet to reduce the the volume of the chamber and eject the medicament through the outlet; a dosing assembly (204) adapted to be secured to said container (202) so as to allow a driver of said dosing assembly (204) to move said piston of said container (202) in said distal direction; Wherein the dosing assembly (204) defines a first fastening device, during fastening of the container (202) and the dosing assembly (204), the first fastening device and the container (202) The second fastening device is engaged, whereby the container (202) is fastened to the dosing assembly ( 204), the predetermined movement is less than one revolution; wherein the sidewall of one of said first fastening means and said second fastening means defines at least two protrusions (206, 206', 206", 206"') extending in a radial direction, said Each of the at least two protrusions is adapted to engage with a corresponding groove (208, 208', 208") defined in a side wall of the other of said first and said second fastening means ;as well as Wherein at least one of said first fastening means and said second fastening means defines an asymmetrical pattern in a plane perpendicular to said axis. 2. The medical delivery system of claim 1, wherein each of the first fastening means and the second fastening means define an asymmetric pattern in the plane perpendicular to the axis. 3. The medical delivery system of claim 1 , wherein at least one of the first fastening means and the second fastening means defines less than two lines of symmetry in the plane perpendicular to the axis. Wire. 4. The medical delivery system of claim 1, wherein at least one of the first fastening device and the second fastening device does not define a line of symmetry in the plane perpendicular to the axis. 5. The medical delivery system according to claim 1, wherein said plane extends through all of said at least two protrusions (206, 206', 206", 206"') or corresponding grooves (208, 208' , 208"). 6. The medical delivery system according to any one of claims 1-5, wherein each of said at least two protrusions or corresponding grooves defines a center point, and wherein any two centers around said axis The angle between points is different than 180 degrees. 7. The medical delivery system of claim 1, wherein two of the at least two protrusions (206, 206', 206", 206"') or corresponding grooves (208, 208', 208") The circumferential range of one or more is different. 8. The medical delivery system according to any one of claims 1-5, wherein the at least two protrusions (206, 206', 206", 206"') or corresponding grooves (208, 208' , 208") define an inclined surface (218). 9. The medical delivery system of claim 1, further comprising an axially extending encoding mechanism (214, 228, 242) defined by the proximal surface (230) of the container (202). ) and the corresponding distal face of the dosing assembly (204), the proximal face of the container (202) defines one or more axially extending protrusions (214) or notches (228), in which During fastening of the container (202) to the dosing assembly (204), the axially extending protrusion or indentation matches one or more of the far-facing coding surfaces (246) of the dosing assembly (204) Each of the notches or protrusions (242) cooperates, whereby if each of the far-facing coding surface and the proximal end face does not define one or more predetermined protrusions selected from a predetermined set of protrusions or notches. or notch, the intended movement is prevented. 10. The medical delivery system of claim 1, wherein the container (202) includes a cartridge holder defining the second fastening means and a cartridge defining the chamber, and wherein the cartridge is non-removably Attached to the cartridge holder. 11. The medical delivery system of claim 1, wherein at least a portion of the predetermined movement is parallel axial and rotational movement. 12. The medical delivery system according to claim 11, wherein said first fastening means and/or said second fastening means are adapted to prevent a part of said axial and/or rotational movement of said predetermined movement , whereby coupling of the container (202) to the dosing assembly (204) is prevented if each of the first fastening means and the second fastening means does not define a predetermined coded geometry. 13. The medical delivery system of claim 12, wherein the coded geometry of the first fastening device and/or the second fastening device is defined by at least one of: the first The circumferential extent of the fastening means and the second fastening means, the axial extent of the first fastening means and the second fastening means, the first fastening means and the second fastening means The radial extent of the device and the circumferential position of the first fastening device and the second fastening device. 14. A medical delivery system comprising: a) a first container (202) and b) a second container (202), each adapted to contain a medicament in a chamber defined by the respective said container (202) and a slidably arranged piston which can moving along its axis in a distal direction towards the outlet so as to reduce the volume of the chamber and eject the medicament through the outlet; c) a first dosing assembly (204), wherein said first container (202) is adapted to be fastened to the first dosing assembly (204), wherein the first dosing assembly is adapted to allow a driver of the first dosing assembly to move the piston of the first container in the distal direction, wherein the first dosing assembly defines a first fastening means , during fastening of the first container to the first dosing assembly, the first fastening means of the first dosing assembly engages the second fastening means of the first container, by Said first container passes through a predetermined position defined by at least one of said first fastening means of said first dosing assembly (204) and said second fastening means of said first container (202). movement secured to said first metering assembly, said predetermined movement being less than one revolution; wherein the sidewall of one of said first fastening means of said first dosing assembly (204) and said second fastening means of said first container (202) defines at least two extended protrusions (206, 206', 206", 206"'), each of said at least two protrusions being adapted to be associated with said first fastening means defined in said first dosing assembly and said engages with a corresponding groove (208, 208', 208") in the side wall of the other of the second fastening means; and wherein at least one of said first fastening means of said first dosing assembly (204) and said second fastening means of said first container (202) is defined in a plane perpendicular to said axis asymmetric pattern; d) a second dosing assembly (204), wherein said second container (202) is adapted to be fastened to said second dosing assembly (204), Wherein the second dosing assembly (204) is adapted to allow the driver of the second dosing assembly (204) to move the piston of the second container (202) in the distal direction, wherein the second dosing assembly ( 204) defines a first fastening device, during fastening of the second container (202) and the second dosing assembly (204), the first fastening of the second dosing assembly (204) device is engaged with the second fastening means of the second container (202), whereby the second container passes through the first fastening means of the second dosing assembly (204) and the second container (202) at least one of said second fastening means is fastened to said second dosing assembly (204) by a defined predetermined movement, said predetermined movement being less than one revolution; Wherein the side wall of one of the first fastening means of the second dosing assembly (204) and the second fastening means of the second container (202) defines at least two protrusions (206, 206', 206", 206"'), each of said at least two protrusions is adapted to be associated with said first fastening means and said first fastening means defined in said second dosing assembly. corresponding grooves (208, 208', 208") in the side walls of the other of the two fastening means engage; and wherein at least one of said first fastening means of said second dosing assembly (204) and said second fastening means of said second container (202) defines a non- Symmetrical patterns; at least two of the following: said first fastening means of said first dosing assembly (204), said first fastening means of said second dosing assembly (204), said second fastening means of said first container (202), and said second fastening means of said second container (202), It is adapted to prevent said first dosing assembly (204) and said second container (202) from being fastened to each other, and to prevent said second dosing assembly (204) and said first container (202) from being fastened to each other. 15. The medical delivery system according to claim 14, wherein required for coupling and decoupling the first container (202) from the first dosing assembly (204) and for coupling the second container (202) said predetermined movements coupled to said second metering assembly (204) are substantially the same. 16. A container suitable for use in a medical delivery system according to any one of claims 1-13, said container (202) being adapted within a chamber defined by said container and a slidably arranged piston accommodating a medicament, the piston is movable along its axis in the distal direction towards the outlet so as to reduce the volume of the chamber and eject the medicament through the outlet, the container (202) includes a dosing assembly adapted to (204) The second fastening device engaged by the first fastening device, the second fastening device defines at least two radially extending protrusions (206, 206', 206", 206"') or At least two grooves (208, 208', 208") on one side wall of two fastening means, characterized in that said second fastening means define an asymmetrical pattern in a plane perpendicular to said axis. 17. A container according to claim 16, wherein said second fastening means defines less than two lines of symmetry in said plane perpendicular to said axis. 18. The container of claim 16, wherein the second fastening means does not define a line of symmetry in the plane perpendicular to the axis. 19. The container of claim 16, wherein two or more of the at least two protrusions (206, 206', 206", 206"') or grooves (208, 208', 208") The circumferential extent of each is different. 20. The container of claim 16, wherein the proximal face (230) of the container (202) defines one or more axially extending protrusions (214) or indentations (228). 21. The container according to claim 16, wherein the container (202) comprises a cartridge holder, the second fastening means being defined by or attachable to the cartridge holder. 22. A dosing assembly suitable for use in a medical delivery system according to any one of claims 1-13, wherein the dosing assembly (204) is adapted to be fastened to a container (202) adapted to be Medicament is contained in a chamber defined by the container and a slidably disposed piston, the piston being movable along its axis in a distal direction towards the outlet to reduce the volume of the chamber and expel the drug through the outlet. medicine; said dosing assembly (204) has a driver to move said piston of said container in said distal direction; wherein said dosing assembly (204) defines first fastening means which engages second fastening means of said container during fastening of said container to said dosing assembly, by said container is secured to said dosing assembly by a predetermined movement defined by at least one of said first fastening means and said second fastening means, said predetermined movement being less than one revolution; Wherein the first fastening means of the dosing assembly (204) defines at least two protrusions (206, 206', 206", 206"') extending in a radial direction or on the side of the first fastening means At least two grooves (208, 208', 208") in the wall, wherein said first fastening means define an asymmetrical pattern in a plane perpendicular to said axis.

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