CN101455755B - Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof - Google Patents
Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof Download PDFInfo
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- CN101455755B CN101455755B CN2008101519195A CN200810151919A CN101455755B CN 101455755 B CN101455755 B CN 101455755B CN 2008101519195 A CN2008101519195 A CN 2008101519195A CN 200810151919 A CN200810151919 A CN 200810151919A CN 101455755 B CN101455755 B CN 101455755B
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- 201000001881 impotence Diseases 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 238000005728 strengthening Methods 0.000 title abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 32
- 241000005787 Cistanche Species 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 31
- 238000009472 formulation Methods 0.000 claims description 25
- 239000000463 material Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 6
- 230000001976 improved effect Effects 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 241000271309 Aquilaria crassna Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000241463 Cullen corylifolium Species 0.000 abstract 1
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 241001016310 Epimedium grandiflorum Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 241000146384 Glaux Species 0.000 abstract 1
- 238000010411 cooking Methods 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 6
- 238000010792 warming Methods 0.000 description 6
- 238000007689 inspection Methods 0.000 description 5
- 230000001568 sexual effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 241000208966 Polygala Species 0.000 description 3
- 241001446509 Psoralea Species 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
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- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
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- 230000002085 persistent effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
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- 206010003549 asthenia Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001856 erectile effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 206010036596 premature ejaculation Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
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Abstract
A yang-qi-strengthening preparation treating yang-qi-deficiency type impotence and a preparation method thereof, wherein the yang-qi-strengthening preparation is made from following raw materials in terms of weight ratio: 120-240% of herba cistanches, 150-260% of barrenwort, 100-200% of malaytea scurfpea, 160-240% of fructus cnidii, 80-160% of eucommia, 4-8% of Chinese eaglewood, 140-240% of dodder, 120-260% of fructus ligustri lucidi, 4-6% of asarum, 120-170% of radix paeoniae and 80-120% of thinleaf milkwort root-bark. effective components in raw materials is extracted by water cooking extract method and activity thereof is kept so that dissolution of the effective components is greatly improved, absorption of medicament is better and bioavailability is improved. In addition, the medicament is a pure Chinese traditional medical preparation with no side effect caused after being haven by patients and with high security. The preparation method is simple processes and convenient operation.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of with Chinese medicine be raw material make be used for the treatment of yang-invigorating formulation of yang-insufficiency type impotence and preparation method thereof.
Background technology
Sexual impotence is a kind of because man's erectile disfunction, faces room penis anorthosis, and it is not hard perhaps to erect, and is perhaps hard and soon, so that can not finish the disease of normal sexual intercourse, is one of modal disease of male sexual disorder.Though it is many to be used for the treatment of the types of drugs of sexual impotence at present clinically, specific aim is not strong, and the toxic and side effects of some medicine is big, so take back DeGrain for treatment belongs to this disease of yang-insufficiency type impotence.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment yang-insufficiency type impotence effect obvious, thereby with strong points, and the yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned yang-invigorating formulation.
In order to achieve the above object, the yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Herba Cistanches 120-240 Herba Epimedii (system) 150-260 Fructus Psoraleae 100-200
Fructus Cnidii 160-240 Cortex Eucommiae 80-160 Lignum Aquilariae Resinatum 4-8
Semen Cuscutae 140-240 Fructus Ligustri Lucidi 120-260 Herba Asari 4-6
Radix Paeoniae Rubra 120-170 Radix Polygalae 80-120
The described preparation method that is used for the treatment of the yang-invigorating formulation of yang-insufficiency type impotence is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Lignum Aquilariae Resinatum full dose, Herba Asari, each 1/3rd amount of Radix Paeoniae Rubra, Radix Polygalae 1/4th amounts are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Herba Asari, Radix Paeoniae Rubra, 7 kinds of medicine materials of Radix Polygalae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
Kidney yang is the Yuanyang of the whole body, is the root of human body, if asthenia of renal yang, decline of the fire from the gate of life can cause sexual impotence, premature ejaculation, multiple andropathy such as sterile.We's legislation " nourishing renal yang to restrict excessive yin is with training Yuanyang ".Yuanyang in the right training the kidney invigorating must " treating YANG within YIN ", thus in training kidney-replenishing the product of compatibility YIN nourishing replenishing essence again, to reach the merit of YIN and YANG promoting each other.The hot temperature of Herba Epimedii in the side, kidney invigorating and YANG supporting, strong muscles and bones; The sweet temperature of Herba Cistanches, kidney-replenishing, the kidney tonifying essence, temperature and not dry is mended and not high, is the strengthening by means of tonics medicine of character gentleness; The hot temperature of Fructus Cnidii, warming the kidney to invigorate YANG; The hot temperature of Fructus Psoraleae, reinforcing the kidney and supporting YANG, controlling nocturnal emission with astringent drugs antidiarrheal, more than four medicines, warming and recuperating the kidney-YANG is monarch drug altogether.Semen Cuscutae Xin Ganping can YANG invigorating, but tonifying YIN again; The sweet cold of Fructus Ligustri Lucidi, replenishing kidney-YIN is so grown and oiliness; The sweet temperature of the Cortex Eucommiae, invigorating the liver and kidney, bone and muscle strengthening; The arduous temperature of Lignum Aquilariae Resinatum, but both warming the kidney improving inspiration by invigorating kidney-QI, but promoting the circulation of QI to relieve pain again, more than four product; Enriching yin and nourishing kidney are ministerial drug altogether.The hot temperature of Radix Polygalae, mind tranquilizing and the heart calming, and can eliminate the phlegm and have one's ideas straightened out; The hot temperature of Herba Asari, though commonly usedly be the medicine of dispersing wind-cold, Herba Asari is gone into kidney channel, it is strong to disperse the logical power of temperature, just in this medicine of adding, the effect of the kidney warming of can strengthening activating yang, this two product mind calming is sensible, is adjuvant drug altogether.The Radix Paeoniae Rubra bitter cold has clearing away heat and cooling blood, the merit of removing blood stasis and activating blood flow, but add both descending external genitals of priming of this product, it is dry strong to make hot using warming therapy again, thinks messenger drug.The all medicines in full side share, and play warming and recuperating the kidney-YANG altogether, the effect of enriching kidney essence.
Below in conjunction with embodiment yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
The yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Cistanches 200 Herba Epimedii (system) 200 Fructus Psoraleaes 166
Fructus Cnidii 200 Cortexs Eucommiae 100 Lignum Aquilariae Resinatum 5
Semen Cuscutae 200 Fructus Ligustri Lucidi 200 Herba Asaris 5
Radix Paeoniae Rubra 150 Radix Polygalaes 100
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Lignum Aquilariae Resinatum full dose, Herba Asari, each 1/3rd amount of Radix Paeoniae Rubra, Radix Polygalae 1/4th amounts are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Herba Asari, Radix Paeoniae Rubra, 7 kinds of medicine materials of Radix Polygalae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Cistanches 120 Herba Epimedii (system) 150 Fructus Psoraleaes 100
Fructus Cnidii 160 Cortexs Eucommiae 80 Lignum Aquilariae Resinatum 4
Semen Cuscutae 140 Fructus Ligustri Lucidi 120 Herba Asaris 4
Radix Paeoniae Rubra 120 Radix Polygalaes 80
Preparation method is with embodiment 1.
Embodiment 3:
The yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Herba Cistanches 240 Herba Epimedii (system) 260 Fructus Psoraleaes 200
Fructus Cnidii 240 Cortexs Eucommiae 160 Lignum Aquilariae Resinatum 8
Semen Cuscutae 240 Fructus Ligustri Lucidi 260 Herba Asaris 6
Radix Paeoniae Rubra 170 Radix Polygalaes 120
Preparation method is with embodiment 1.
In order to verify the therapeutic effect of this yang-invigorating formulation, the patient that the inventor utilizes the capsule that belongs to oral solid formulation in the above-mentioned yang-invigorating formulation that 330 examples are suffered from yang-insufficiency type impotence has carried out system's clinical observation, 21-30 year patient's 90 examples wherein, 31-40 year 119 examples, 41-50 year 121 examples, 3 of each medications, every day 2 times, 60 days is 1 course of treatment.After 1 course of therapy, cure (normally sexual intercourse, the inspection index recovers normal) 82 examples altogether, account for 24.85%; Produce effects (erection hardness and persistent period obviously improve, and can be interrupted to have sexual intercourse, and the inspection index is obviously improved) 97 examples account for 29.39%; Effectively (there are improvement erection hardness and persistent period, and idol can have sexual intercourse, and the inspection index is improved slightly) 113 examples account for 34.24%; Invalid (normally sexual intercourse checks that the preceding nothing of index and treatment changes) 38 examples account for 11.52%; Total effective rate is 89.48%.After 2 course of therapy, cure 166 examples altogether, account for 50.30%; Produce effects 83 examples account for 25.15%; Effective 60 examples account for 18.18%; Invalid 21 examples account for 6.37%; Total effective rate is 93.63%.
Simultaneously, the inventor analyzes therapeutic effect and age, therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1 respectively, table 2.
Table 1: yang-invigorating formulation therapeutic effect provided by the invention and age relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is 0.050＞P＞0.025, can prove that thus taking yang-invigorating formulation provided by the invention treats yang-insufficiency type impotence, and the therapeutic effect of each age group is not changed with the age.
Table 2: yang-invigorating formulation therapeutic effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 2
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking yang-invigorating formulation provided by the invention treats yang-insufficiency type impotence, and along with going deep into of treatment, cure rate, obvious effective rate, effective percentage all obviously improve.
Claims (2)
1. yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence is characterized in that: the described yang-invigorating formulation that is used for the treatment of yang-insufficiency type impotence is that the following medicine material of weight ratio is made by consumption:
Herba Cistanches 120-240 Herba Epimedii (processed) 150-260 Fructus Psoraleae 100-200
Fructus Cnidii 160-240 Cortex Eucommiae 80-160 Lignum Aquilariae Resinatum 4-8
Semen Cuscutae 140-240 Fructus Ligustri Lucidi 120-260 Herba Asari 4-6
Radix Paeoniae Rubra 120-170 Radix Polygalae 80-120.
2. preparation method that is used for the treatment of the yang-invigorating formulation of yang-insufficiency type impotence as claimed in claim 1, it is characterized in that: the described preparation method that is used for the treatment of the yang-invigorating formulation of yang-insufficiency type impotence is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Lignum Aquilariae Resinatum full dose, Herba Asari, each 1/3rd amount of Radix Paeoniae Rubra, Radix Polygalae 1/4th amounts are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Herba Asari, Radix Paeoniae Rubra, 7 kinds of medicine materials of Radix Polygalae and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101519195A CN101455755B (en) | 2008-09-27 | 2008-09-27 | Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof |
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| CN2008101519195A CN101455755B (en) | 2008-09-27 | 2008-09-27 | Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof |
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| CN101455755A CN101455755A (en) | 2009-06-17 |
| CN101455755B true CN101455755B (en) | 2011-02-02 |
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| CN2008101519195A Expired - Fee Related CN101455755B (en) | 2008-09-27 | 2008-09-27 | Yang-strengthening preparation for treating yang-insufficiency type impotence and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070999B (en) * | 2013-01-22 | 2015-03-18 | 青岛市市立医院 | Medicine composition for treating premature ejaculation and preparation method of same |
| CN103705724B (en) * | 2013-12-18 | 2016-10-05 | 孙红艳 | The medicine for external use for the treatment of impotence |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1488743A (en) * | 2002-12-31 | 2004-04-14 | 张戈平 | Supplemental strengthening wine and preparing process thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1184659A (en) * | 1997-11-14 | 1998-06-17 | 张锡昆 | Traditional Chinese medicine for tonifying kidney and strengthening spleen and stomach |
| CN1488743A (en) * | 2002-12-31 | 2004-04-14 | 张戈平 | Supplemental strengthening wine and preparing process thereof |
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Effective date of registration: 20170606 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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