CN101450177A - Traditional Chinese medicine composition with blood sugar reducing function and preparation method thereof - Google Patents
Traditional Chinese medicine composition with blood sugar reducing function and preparation method thereof Download PDFInfo
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- CN101450177A CN101450177A CNA2007101785199A CN200710178519A CN101450177A CN 101450177 A CN101450177 A CN 101450177A CN A2007101785199 A CNA2007101785199 A CN A2007101785199A CN 200710178519 A CN200710178519 A CN 200710178519A CN 101450177 A CN101450177 A CN 101450177A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a Chinese medicinal composition for reducing blood glucose and a preparing method thereof. The Chinese medicinal composition is prepared from balsam pear, astragalus and rhizoma polygonatum by weight rate that can be prepared any one ordinary oral preparation. The Chinese medicinal composition has effect in reducing blood glucose, and can be used for treating diabetes.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, belong to Chinese medicine and field of health care food with function of blood sugar reduction.
Background technology
Diabetes are the one group of Developmental and Metabolic Disorder syndromes that is caused by the h and E factor interaction.Long-term diabetes can cause the chronic complicating diseases of a plurality of systems organ, cause dysfunction and depletion, become disable, lethal main cause.At present, the prevalence of diabetes had the trend of remarkable rising in recent years in the population of China.Because the cause of disease and the pathogenesis of diabetes are not clear fully as yet, therefore also lack effective etiological treatment method at present.Clinically treatment of diabetes is adopted insulinize and oral hypoglycemic drug therapy more now, yet diabetes spp is in a kind of lifelong participation disease, need long-term prescription, the drug administration by injection method of insulin tends to bring many inconvenience to the patient, and clinical orally-taken blood sugar reducing medicine commonly used belongs to chemical drugs more, takes for a long time also and can cause a series of untoward reaction.In view of there being above problem, so exploitation a kind of blood sugar lowering Chinese medicine and health food safe, effective, that be suitable for taking for a long time are badly in need of on present market very much.
Summary of the invention
The object of the invention just provides a kind of Chinese medicine composition with function of blood sugar reduction.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The present invention is achieved by the following technical solutions:
The present invention is made by the following weight proportion raw material:
Fructus Momordicae charantiae 10-30 part, Radix Astragali 9-30 part, Rhizoma Polygonati 9-15 part.
Be preferably:
15 parts in Fructus Momordicae charantiae, 20 parts of the Radixs Astragali, 12 parts of Rhizoma Polygonatis.
The preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Momordicae charantiae with described weight proportion, the Radix Astragali, Rhizoma Polygonati adds water or ethanol extracts, extracting solution is concentrated, dry, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
The preferred for preparation method of Chinese medicine composition of the present invention is as follows:
Fructus Momordicae charantiae with described weight proportion, the Radix Astragali, Rhizoma Polygonati adds twice of the ethanol extraction of 10 times of amounts and 8 times amount 70%, filter, merging filtrate, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure, make dry extract, be ground into powder, add various conventional adjuvant required when preparing different dosage form, as diluent, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc., method of Chinese medicinal with routine is prepared into any peroral dosage form commonly used, as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid etc.
Each drug mechanism is as follows among the present invention:
Fructus Momordicae charantiae: having clears away heart-fire makes eye bright, the effect of QI invigorating antipyretic, and Fructus Momordicae charantiae contains Charantin, Charantin etc., and pharmacological evaluation proves that Fructus Momordicae charantiae has the effect of tangible blood sugar lowering.
The Radix Astragali: effect with benefiting QI for strengthening the superficies, diuretic, promoting pus discharge and tissue regeneration strengthening, the astragalus polysaccharides that contains in the Radix Astragali has the effect of two-ways regulation blood glucose, can make that the blood sugar level of mice significantly descends behind the glucose load, and the mouse blood sugar level rising that can obviously cause antiadrenergic drug, and insulin hypoglycemia is not had obvious influence.
Rhizoma Polygonati: sweet in the mouth, property are put down, and are a kind of of tonic.Function such as have spleen invigorating, the kidney invigorating, lung moistening, promote the production of body fluid.Pharmacological research shows that Rhizoma Polygonati has hypoglycemic effect.
In the present composition, Fructus Momordicae charantiae is less edible in people's diet as the plant of bitterness is arranged, and has wherein contained the trace element of a large amount of diabetes patient's needs; Radix Astragali QI invigorating diuretic, Rhizoma Polygonati spleen reinforcing kidney, three medicines are harmonious and the body of fundamentally comprehensively regulating the diabetes patient, improve diabetes patient's physical condition, and three flavor medicines all have very clear and definite blood sugar lowering pharmacology effect, can be with diabetes patient's blood glucose regulation to normal level.
In sum, the present composition has that clearing away heat and cooling blood, relieving restlessness quench the thirst, hypoglycemic effect.Can be used for treating diabetes.Can be used for preparing the Chinese medicine and the health product of prevention and treatment diabetes.
The present invention with respect to prior art have determined curative effect, have no side effect, taking convenience, cheap advantage.
Further set forth the beneficial effect of Chinese medicine composition of the present invention by following experiment.
For showing the hypoglycemic effect of the present invention, entrust the specified health food functional check of Ministry of Public Health mechanism the present invention to be carried out the animal experiment of blood sugar regulation to diabetes.Table 1 is the influence of the present invention to alloxan induced hyperglycemia rat blood sugar, and table 2 is the influence of the present invention to normal rat blood sugar for the influence of the present invention to alloxan induced hyperglycemia rat post-prandial glycemia, table 3.
Table 1 the present invention is to the influence of alloxan induced hyperglycemia rat blood sugar
* compare p＜0.05 with the hyperglycemia model group
Table 2 the present invention is to the influence of alloxan induced hyperglycemia rat post-prandial glycemia
* p＜0.01 of comparing with the hyperglycemia model group
Table 3 the present invention is to the influence of normal rat blood sugar (X ± SD)
Test initial stage F=0.011, P=0.998; Test F=2.102 in latter stage, P=0.118
Table 1-3 result shows that the present invention does not have influence to normal rat blood sugar.High dose of the present invention has tangible reduction effect to the hyperglycemic rat blood glucose due to the alloxan, and middle and high dosage can improve the carbohydrate tolerance by the caused hyperglycemic rat of alloxan.
The specific embodiment
Embodiment 1:
The preparation of the capsule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 15kg, Radix Astragali 20kg, Rhizoma Polygonati 12kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, filter, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is broken into powder, drying, the snap fit capsule of packing into.
Embodiment 2:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 10kg, Radix Astragali 9kg, Rhizoma Polygonati 9kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 3:
The preparation of the granule of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Radix Astragali 30kg, Rhizoma Polygonati 15kg, standby;
B) Fructus Momordicae charantiae, the Radix Astragali, Rhizoma Polygonati are extracted twice with 10 times of amounts and 8 times of water gagings, merge filtrate twice, be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added ethanol and make adhesive, add appropriate amount of starch and make filler, make granule.
Embodiment 4:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Radix Astragali 9kg, Rhizoma Polygonati 9kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 80%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 5:
The preparation of the tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 30kg, Radix Astragali 20kg, Rhizoma Polygonati 12kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added adjuvant and make granule, and dry, and compacting is in flakes.
Embodiment 6:
The preparation of the effervescent tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 25kg, Radix Astragali 15kg, Rhizoma Polygonati 9kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added tartaric acid, sodium bicarbonate, sweeting agent, filler mixing, granulate with dehydrated alcohol, drying adds the lubricant mixing, tabletting, promptly.
Embodiment 7:
The preparation of the dispersible tablet of Chinese medicine composition of the present invention
A) take by weighing Fructus Momordicae charantiae 20kg, Radix Astragali 12kg, Rhizoma Polygonati 12kg, standby;
B) with Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati ethanol extraction twice with 10 times of amounts and 8 times of amounts 70%, merge filtrate twice, reclaim ethanol and be evaporated to relative density and measure 1.25-1.30 down for 60 ℃, drying under reduced pressure makes dry extract;
C) dry extract is pulverized, added disintegrating agent, filler or diluent, mix homogeneously adds binding agent and makes soft material, the system granule, and drying adds part disintegrating agent, fluidizer or lubricant mixing, tabletting, promptly.
Claims (5)
1, a kind of Chinese medicine composition with hypoglycemic activity is characterized in that, it is to be made by following bulk drugs: Fructus Momordicae charantiae 10-30 part, Radix Astragali 9-30 part, Rhizoma Polygonati 9-15 part.
According to the Chinese medicine composition of claim 1, it is characterized in that 2, it is to be made by following bulk drugs: 15 parts in Fructus Momordicae charantiae, 20 parts of the Radixs Astragali, 12 parts of Rhizoma Polygonatis.
3, the preparation method of claim 1 or 2 described Chinese medicine compositions is characterized in that, this method is:
Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati of described weight proportion added water or ethanol extracts, extracting solution is concentrated, drying makes dry extract, is ground into powder, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
4, the preparation method of Chinese medicine composition according to claim 3 is characterized in that, it comprises the following steps:
Fructus Momordicae charantiae, the Radix Astragali, the Rhizoma Polygonati of described weight proportion added 70% ethanol extract 2 times, extracting solution is merged, the concentrating under reduced pressure relative density is measured 1.25-1.30 down for 60 ℃, and drying under reduced pressure makes dry extract, is ground into powder, is prepared into active component; The gained active component is mixed with adjuvant, make any medicament on the pharmaceutics.
5, claim 1 or 2 described Chinese medicine compositions are used to prepare prevention and the medicine of treatment diabetes disease or the application of health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785199A CN101450177A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood sugar reducing function and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101785199A CN101450177A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood sugar reducing function and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101450177A true CN101450177A (en) | 2009-06-10 |
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| CNA2007101785199A Pending CN101450177A (en) | 2007-11-30 | 2007-11-30 | Traditional Chinese medicine composition with blood sugar reducing function and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285231A (en) * | 2013-05-13 | 2013-09-11 | 刘扬 | Medicine composition for diabetes adjunctive therapy and preparation method thereof |
| CN108159268A (en) * | 2018-03-26 | 2018-06-15 | 王桂芬 | A kind of pharmaceutical composition for being used to treat diabetes |
| CN108524764A (en) * | 2017-03-06 | 2018-09-14 | 唐兵 | A kind of 5-linked balsam pear for treating diabetes is scattered |
| CN109939176A (en) * | 2018-02-02 | 2019-06-28 | 中山大学 | A kind of pharmaceutical composition for treating diabetes and preparation method thereof |
-
2007
- 2007-11-30 CN CNA2007101785199A patent/CN101450177A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103285231A (en) * | 2013-05-13 | 2013-09-11 | 刘扬 | Medicine composition for diabetes adjunctive therapy and preparation method thereof |
| CN108524764A (en) * | 2017-03-06 | 2018-09-14 | 唐兵 | A kind of 5-linked balsam pear for treating diabetes is scattered |
| CN109939176A (en) * | 2018-02-02 | 2019-06-28 | 中山大学 | A kind of pharmaceutical composition for treating diabetes and preparation method thereof |
| CN109939176B (en) * | 2018-02-02 | 2022-02-25 | 中山大学 | A kind of pharmaceutical composition for treating diabetes and preparation method thereof |
| CN108159268A (en) * | 2018-03-26 | 2018-06-15 | 王桂芬 | A kind of pharmaceutical composition for being used to treat diabetes |
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