CN101450055A - Soluble powder for treating livestock and poultry bacterial infection and parasitic disease - Google Patents

Abstract

The invention relates to a soluble powder for treating livestock and poultry bacterial infection and parasitosis, comprising nortloxacin lactate, trimethoprim and auxiliary materials, the medicament of the invention is taken as antibiotic medicament, is mainly used for treating various diseases and parasitosis caused by sensitive bacterias, has better curative effects for pig toxoplasmosis, pig hydropsy, poultry, rabbit coccidiosis, the nortloxacin lactate and the trimethoprim are compatible with each other for using and generating cooperating action, the medicament of the invention has excellent oral administration absorption effect and high safety.

Description

Soluble powder for treating bacterial infection and parasitic diseases of livestock and poultry

technical field

The invention belongs to the field of veterinary medicine, in particular to a soluble powder for treating bacterial infection and parasitic diseases of livestock and poultry.

Background technique

In the process of livestock and poultry breeding, parasitic diseases often occur, but because parasitic diseases generally do not cause rapid and mass death of livestock and poultry (coccidiosis in poultry and rabbits can cause death), and are often farmed because of insignificant clinical symptoms households ignore. In fact, the occurrence of parasitic diseases has a considerable impact on the healthy growth, production and economic benefits of the livestock and poultry industry, which must be paid enough attention and taken seriously. Because once parasitic diseases occur in livestock and poultry, firstly, nutrients are eroded and plundered by parasites and fearlessly consumed, resulting in serious consumption of feed; secondly, parasites and migration of parasites cause tissue damage and pathological changes in livestock and poultry, which in turn cause systemic symptoms; The third is to hinder the growth and development of young livestock, reduce the production performance of livestock and poultry, and affect the quality and output of livestock and poultry products; the fourth is to cause regional epidemics, bring huge economic losses to animal husbandry production, and more seriously, threaten human beings. own health.

Contents of the invention

Based on the foregoing, the object of the present invention is to provide a soluble powder for the treatment of livestock and poultry bacterial infections and parasitic diseases

The object of the present invention is achieved in that: the sulfamethoxine sodium is 4.5%-5.5%, the trimethoprim 0.5%-1.5%, and the adjuvant 93%-95% in percentage by weight.

The auxiliary materials include: anhydrous glucose, oral glucose, etc., preferably anhydrous glucose.

In order to obtain a better effect, the preferred components are: sulfamethoxine sodium 5%, trimethoprim 1%, and auxiliary materials 94%.

The present invention can be prepared by adopting common process methods and equipment in the industry. Preferably adopt the following method to prepare, comprising steps:

First, crush sulfamethoxine sodium, trimethoprim and the auxiliary materials used, and pass through a 60-mesh sieve after crushing; take sulfamethoxine sodium, trimethoprim and the same amount of auxiliary materials to dilute in equal amounts Dilute, mix, and pass through a 60-mesh fine sieve three times to obtain a mixture; mix the mixture with the remaining auxiliary materials evenly, and pass the mixture through an 80-mesh fine sieve three times to obtain the product.

Sulfamethoxine sodium: It is the sulfonamide drug with the strongest antibacterial effect in vivo and in vitro, and has a strong inhibitory effect on most Gram-positive and negative bacteria, and bacteria are slow to develop resistance to this drug. It is mainly used for various diseases caused by sensitive bacteria, and has a good curative effect on swine toxoplasmosis, swine edema, poultry and rabbit coccidiosis.

Trimethoprim: The antibacterial spectrum is similar to that of sulfonamides and has stronger activity. It has antibacterial effect on a variety of Gram-positive and negative bacteria.

In order to understand the curative effect of the medicine of the present invention, a clinical efficacy test was done on a chicken farm in Jinghai County, Tianjin. Get the chicken that suffers from coccidiosis, use the medicine of the present invention to treat, the first dose: add 2.0g of the medicine of the present invention in every 2 liters of water; maintenance dose: add 1.0g of the medicine of the present invention in every 2 liters of water, and use continuously for 7 days as one course of treatment. After a course of treatment, most of the affected chickens were cured, and the effective rate reached more than 90%.

Beneficial effect: it can be seen from curative effect test that the medicament of the present invention has definite curative effect in treating livestock and poultry parasitic diseases, and is suitable for popularization and application in animal husbandry production. The formula of the present invention adopts trimethoprim and sulfamethoxine sodium two kinds of medicines to be used in combination, which can produce synergistic effect, and both medicines have good curative effect on porcine toxoplasma and poultry coccidiosis, etc., and oral absorption is good , with higher security.

Detailed ways

Embodiment 1: Sulfa-metamethoxine sodium 45g, trimethoprim 5g and used adjuvant anhydrous glucose 950g are pulverized earlier, and cross 60 mesh sieves after pulverizing; Get sulfa-metamethoxine sodium, trimethoprim and The same amount of auxiliary materials is diluted and mixed with the method of equal incremental dilution, and passed through a 60-mesh fine sieve three times to obtain a mixture; the mixture is evenly mixed with the remaining auxiliary materials, and the mixture is passed through an 80-mesh fine sieve three times to obtain about 1000 g of soluble powder. It contains sulfamethoxine sodium 45g and trimethoprim 5g.

Antibiotics. It is mainly used for various diseases and parasitic diseases caused by sensitive bacteria, and has a good curative effect on swine toxoplasmosis, swine edema, poultry and rabbit coccidiosis. Usage and dosage: first dose: add 2.4g of the medicine of the present invention per kilogram of feed or every 2 liters of water; maintenance dose: add 1.2g of the medicine of the present invention per kilogram of feed or every 2 liters of water, and use continuously for 5-7 days as a course of treatment.

Embodiment 2: Sulfa-metamethoxine sodium 50g, trimethoprim 10g and used adjuvant anhydrous glucose 940g are pulverized earlier, and cross 60 mesh sieves after pulverizing; Get sulfa-metamethoxine sodium, trimethoprim and The same amount of auxiliary materials is diluted and mixed with the method of equal incremental dilution, and passed through a 60-mesh fine sieve three times to obtain a mixture; the mixture is evenly mixed with the remaining auxiliary materials, and the mixture is passed through an 80-mesh fine sieve three times to obtain about 1000 g of soluble powder. It contains sulfamethoxine sodium 50g and trimethoprim 10g.

Antibiotics. It is mainly used for various diseases and parasitic diseases caused by sensitive bacteria, and has a good curative effect on swine toxoplasmosis, swine edema, poultry and rabbit coccidiosis. Usage and dosage: first dose: add 2.0g of the medicine of the present invention per kilogram of feed or every 2 liters of water; maintenance dose: add 1.0g of the medicine of the present invention per kilogram of feed or every 2 liters of water, and use continuously for 5-7 days as a course of treatment.

Embodiment 3: Sulfa-metamethoxine sodium 55g, trimethoprim 15g and used adjuvant anhydrous glucose 930g are first pulverized, and after pulverizing, pass through a 60 mesh sieve; get sulfa-metamethoxine sodium, trimethoprim and The same amount of auxiliary materials is diluted and mixed with the method of equal incremental dilution, and passed through a 60-mesh fine sieve three times to obtain a mixture; the mixture is evenly mixed with the remaining auxiliary materials, and the mixture is passed through an 80-mesh fine sieve three times to obtain about 1000 g of soluble powder. It contains sulfamethoxine sodium 55g and trimethoprim 15g.

Antibiotics. It is mainly used for various diseases and parasitic diseases caused by sensitive bacteria, and has a good curative effect on swine toxoplasmosis, swine edema, poultry and rabbit coccidiosis. Usage and dosage: first dose: add 1.7g of the medicine of the present invention per kilogram of feed or every 2 liters of water; maintenance dose: add 0.9g of the medicine of the present invention per kilogram of feed or every 2 liters of water, and use continuously for 5-7 days as a course of treatment.

Claims (3)

1, a kind of soluble powder that is used for the treatment of livestock and poultry bacterial infection and parasitic disease is characterized in that the medicine that medicine of the present invention comprises is: sulfamonomethoxine sodium, trimethoprim and adjuvant.

2, a kind of soluble powder that is used for the treatment of livestock and poultry bacterial infection and parasitic disease according to claim 1, it is characterized in that: represent to be respectively sulfamonomethoxine sodium 4.5%-5.5% with percentage by weight, trimethoprim 0.5%-1.5%, adjuvant 93%-95%, described adjuvant comprises: anhydrous glucose, oral glucose etc. are preferably anhydrous glucose.

3, a kind of soluble powder that is used for the treatment of livestock and poultry bacterial infection and parasitic disease according to claim 1, it is characterized in that: preferred ingredient is: sulfamonomethoxine sodium 5%, trimethoprim 1%, adjuvant 94%.