CN101437563B - atomizer - Google Patents

Abstract

An atomiser (1), a reservoir (3) and a method are proposed for the delivery and in particular the atomisation of a formulation (2), particularly a powder. A pump and a spring (14) are arranged inside the annular reservoir, wherein the pump and the spring (14) are moveable radially and in a sliding manner. The pump is actuated by the spring (14) to put air under pressure for discharging powder from the reservoir (3). The reservoir (3) comprises receptacles (4) or cavities each comprising an insert with a respective dose of the formulation (2). The receptacles (4) are constructed as separate parts and/or arranged on a common or annular carrier and/or are sealed separately and/or on its outer circumferential periphery. The spring (14) is tensioned and the air is sucked into the pump. Then, the next receptacle (4) and a connecting element (24) are aligned relative to each other. Finally, the aligned receptacle (4) is pierced by the connecting element for supplying the air.

Description

Nebulizer

Technical field

The present invention relates to nebulizer as the preamble of claim 1 or 19, relate to the storage for nebulizer as the preamble of claim 20, and relate to the method for delivery formulation as the preamble of claim 32.

The invention particularly relates to for sucking or sending and atomization for the preparation of other medical treatment or therapeutic use.Especially preferably, the present invention relates to contain specifically sending of at least one active substance or the medical preparation formed by least one active substance, pharmaceutical preparation and/or treatment preparation.

The invention particularly relates to a kind of inhaler.Between atomization period, produce and there is the preferably very meticulous solid in 1 to 10 μ m scope of the suction of being specifically used for and/or mist agent or the spray cloud of liquid particle.

Preparation is preferably powder.Especially preferably, therefore the present invention relates to a kind of powder inhalator.Yet, preferably also comprise liquid according to terms " formulation " of the present invention, term " liquid " should be interpreted as that (especially) comprises solution, suspension, aaerosol solution (mixture of solution and suspension), dispersion liquid, its mixture etc. on than broad sense simultaneously.

Following description is mainly sending and atomization or, for a kind of powder inhalator (although the present invention is not limited to this), description also can be used in particular for other inhalers, nebulizer or dispensing device for powder formulation.

The invention particularly relates to a kind of nebulizer with the preparation through measuring in advance.Particularly, indivedual dosage is included in the independent container such as chamber, foaming bag, insert, capsule etc., and can individually be taken out and atomization.

Background technology

Basically, there are passive type nebulizer and active nebulizer.In the passive type type, the air flow that preparation produces when sucking or breathe via user and discharging.In active type, preparation is discharged and is had nothing to do with breathing during sucking, and can pass through suction process, triggers and sends by so-called respiratory triggering particularly.Particularly, produced the flowing so that delivery formulation of delivery media of air for example or a certain other gases by nebulizer or inhaler self.For reaching this purpose, nebulizer has the delivery apparatus of air pump for example or pressure gas containers.The advantage that active type is better than the passive type type is, in active type, can be independent of user and the sending and atomization of be very easy to reproduction of reaching preparation.

EP0 950 423B1 disclose a kind of for the medium active dispensing device of (particularly, powder), and this dispensing device has a compressed air pump (that is to say piston pump) be incorporated in dispensing device.Dispensing device has a foaming disk, and this foaming disk has a plurality of foaming bags that contain powder that are configured to circle.For activating or open indivedual foaming bags, move axially casing part.

EP1 132 104B1 promptings are a kind of for sending the active dispensing device contained from the medium of at least one medicinal activity material of foamed strip.This dispensing device has one for the fluid of discharging medium (particularly, air) pump, is for following closely (impact spike) and a transverse actuating device setting up the impact that fluid is communicated with between pump and foaming bag, when activating, this transverse actuating device is located the foaming bag and also makes medium discharge with respect to impacting nail.Dispensing device also has a spring, this spring during the first actuation step in tension and can during the second actuation step, by discharging a breech lock, be released into slack position, spring make successively with respect to impact nail locate the foaming bag, by impact nail open foaming bag and air supply to the foaming bag in order to discharge medium.

WO91/06333A1 discloses a kind of active dispensing device with a hollow cylindrical storage, and this storage comprises a plurality of axially extended chamber that contains powder.By axially promoting together dispensing device, compressed air and finally via chamber out of the ordinary, carry air in order to discharge the powder of each dosage in piston pump.

Summary of the invention

Purpose of the present invention is for providing a kind of nebulizer, a kind of storage for nebulizer and a kind of for sending the method for (discharge) preparation, wherein nebulizer out of the ordinary can be very simply, particularly operate intuitively its simple structure and with low cost simultaneously, and/or be of compact construction, particularly low whole height and/or good atomization characteristics.

Above the target of statement is by the nebulizer as claim 1 or 19, solve by the storage as claim 20 or by the method as claim 32.Other are characterized as the theme of dependent claims.

According to an aspect of the present invention, delivery apparatus, energy storage and/or connecting device are configured in the loop configurations of annular storage or container, the preparation that each in this container contains a dosage.This causes simply and especially compact structure.

According on the other hand, delivery apparatus, energy storage and/or connecting device can be linear, radially and/or sliding type moves and/or can move together.This contributes to simple and/or compact structure.

According to another aspect, the delivery media that makes of nebulizer structure can be stored and is under pressure so that delivery formulation by energy storage or spring.Very good atomization characteristics is very simply constructed and is made it possible to reach in this permission, is independent of particularly breathing or the suction of sufferer and/or is independent of the actuating of sufferer and reaches equal atomization characteristics.

Of the present invention is the storage that has a plurality of containers for a kind of more on the one hand, this container comprises respectively insert, wherein this container structure is independent part and/or be configured on common or annular region, and/or sealing and/or seal on its exterior periphery periphery individually.This contributes to simple and/or compact structure.In addition, can reach very good atomization characteristics.

According to another aspect of the invention, the force compresses stored by spring for example delivery media and/or the pressure of air makes delivery media pass through container out of the ordinary.This obtains each atomization characteristics very uniformly of sending or discharging.

According on the other hand, spring is stored in tension and/or by the delivery media suction pump, next container is relative to each other aimed at Connection Element, and finally by Connection Element, sting the container that passes aligning with for supplying with delivery media, that is to say, the container pierced through for hanging oneself is discharged or each dosage of atomization.This allows very simple and/or compact structure.In addition.Very simple and easy operation is possible.

The accompanying drawing explanation

Fig. 1 illustrates the schematic cross-sectional according to the nebulizer proposed in transmission location of the first embodiment;

Fig. 2 illustrate according to Fig. 1 in the schematic cross-sectional of the nebulizer of starting state;

Fig. 3 illustrates in opening or the perspective view of the nebulizer of starting state;

Fig. 4 a illustrates the schematic diagram according to the rail plate in the nebulizer of Fig. 1;

Fig. 4 b illustrates the schematic diagram of opening or excise a part of nebulizer with ratchet mechanism according to Fig. 1;

Fig. 4 c illustrates the schematic cross-sectional according to the nebulizer with locking device of Fig. 1;

Fig. 4 d illustrates the perspective view according to the control loop of the locking device of Fig. 4 c;

Fig. 4 e illustrates another schematic cross-sectional according to the nebulizer with locking device of Fig. 4 c;

Fig. 5 illustrate according to Fig. 1 send or atomization after the schematic cross-sectional of nebulizer;

Fig. 6 illustrates the schematic cross-sectional according to the nebulizer proposed in transmission location of the second embodiment;

Fig. 7 illustrate according to Fig. 6 in starting or the schematic cross-sectional of the nebulizer of open mode;

Fig. 8 illustrate according to the 3rd embodiment in opening or the schematic cross-sectional of the nebulizer proposed of starting state;

Fig. 9 illustrates the schematic diagram according to the nebulizer proposed in transmission location of the 4th embodiment;

Figure 10 illustrate according to Fig. 9 in the schematic cross-sectional of the nebulizer of latch mode not;

Figure 11 illustrates the schematic cross-sectional according to the nebulizer of the state in starting, being pressed together of Fig. 9;

Figure 12 illustrates the schematic cross-sectional according to the nebulizer proposed in transmission location of the 5th embodiment;

Figure 13 illustrate according to Figure 12 in the schematic cross-sectional of the nebulizer of latch mode not;

Figure 14 illustrate according to Figure 12 in starting, the schematic cross-sectional of the nebulizer of coarctate state;

Figure 15 illustrates the schematic cross-sectional according to the nebulizer proposed in transmission location of the 6th embodiment;

Figure 16 illustrate according to Figure 15 in the schematic cross-sectional of the nebulizer of latch mode not;

Figure 17 illustrates the schematic diagram according to the Connection Element of the nebulizer of Figure 16;

Figure 18 illustrates another exemplary details from Figure 16;

Figure 19 illustrates the side view according to the details of the nebulizer in transmission location with enumerator of Figure 15;

Figure 20 illustrate corresponding to Figure 19 in the side view of the nebulizer of latch mode not;

Figure 21 illustrates the perspective view according to the nebulizer with timer of Figure 15;

Figure 22 illustrates the perspective view according to the nebulizer with medicine container of Figure 15;

Figure 23 illustrates the schematic cross-sectional according to the nebulizer proposed in transmission location of the 8th embodiment;

Figure 24 illustrate according to Figure 23 in opening or the schematic cross-sectional of the nebulizer of starting state;

Figure 25 illustrates the schematic diagram according to the transmitting device of the nebulizer of Figure 23;

Figure 26 illustrates the schematic diagram according to the part of the nebulizer proposed of the 9th embodiment;

Figure 27 illustrate corresponding to Figure 26 in the view of the nebulizer of starting state;

Figure 28 illustrates the schematic functional representation according to the nebulizer proposed of the tenth embodiment; And Figure 29 illustrates the schematic cross-sectional according to the nebulizer of Figure 28.

At Zhu Tuzhong, same reference numbers is for identical or like parts, even the description that does not repeat to be associated.Particularly, obtain whereby identical or corresponding advantage and character.

The main element symbol description

1 nebulizer

2 preparations

3 storages

4 containers

5 delivery apparatus

6 pump chambers

7 retractable sacks

8 mouthpieces

9 grids

10 covers

11 delivery sides to

12 axis

13 shells

14 springs

15 gears

16 have screw shell

17 female threads

18 external screw threads

19 inner meshing parts

20 lock arms

21 actuation elements

22 engaged elements

23 transmitting devices

24 connecting devices

25 external engagement parts

26 control cam

27 outthrust

The 27a ratchet

The 27b transfer arm

28 inserts

29 take in chamber

30 openings

31 storage chamber

32 passages

33 finger pieces

34 Connection Elements

35 send passage

36 rotating retainers

37 locking devices

38 breech locks

39 control loops

The 40a lock arm

40b lock arm (shell)

The 40c retainer

The 40d stopper arms

The 40e slidingsurface

41 inner bodies

42 carriages

43 teeth

44 coordinate tooth

45 peripheral openings

46 relieving mechanisms

47 upper case parts

48 lower case parts

49 spring elements

50 snap fit hooks

51 annular shoulders

52 entrances

53 outlets

54 arrows

55 loop brackets

56 dimples

57 blocking vessels

58 bearings

59 enumerators

60 scales

61 windows

62 dimples

63 clocks

64 lids

65 interface channels

66 pinions

67 internal tooths

68 control elements

69 axially engagements

70 first rail plates

71 first engaged elements

72 first sections

73 second sections

74 the 3rd sections

75 second rail plates

76 second engaged elements

77 bearings

78 shoulders

79 slide plates

80 radial components

81 hlding parts

The specific embodiment

Fig. 1 illustrates the nebulizer proposed 1 in transmission location according to the first embodiment with schematic cross-sectional.Particularly, nebulizer 1 is for especially being preferred for the preferred portable type inhaler of mist agent treatment.

Nebulizer 1 is preferably the preparation 2 of powder to send also atomization through design.Particularly.The implication that nebulizer 1 can above be explained is for preparation 2.

Preparation 2 is the indivedual dosage that suck that are specifically used for for being sent in succession by nebulizer 1 through metering in advance preferably.

Nebulizer 1 have storage 3 or through the design with fixing one storage.If necessary, storage 3 can be inserted in nebulizer 1 and optionally be changed to reuse nebulizer 1.

Storage 3 has a plurality of containers 4, the preparation 2 that each container 4 contains a dosage.Container 4 can be for example foaming bag, but preferably contains the insert 28 of the preparation 2 with each dosage.Storage 3 preferably has rigidity and/or circular structure.Particularly, storage 3 or container 4 form loop configurations, the preferred circle distribution around storage 3 of this container 4.

Nebulizer 1 is preferably active type.In the embodiment with shown in example, nebulizer 1 preferably has the delivery apparatus 5 for the delivery media of delivery formulation 2 (being in particular air or a certain other gases).Particularly, delivery apparatus 5 is configured to pump (especially being preferably air pump) or carries delivery media with a certain additive method design.

Particularly, delivery apparatus 5 has a pump chambers 6, and pump chambers 6 is preferably formed, delimits and/or changed by retractable sack 7 and/or a certain other elements of delivery apparatus 5.

Use delivery apparatus 5, particularly, surrounding air can be used as delivery media and is absorbed into and is under pressure.Use delivery media, can be when activating or use nebulizer 1 (particularly, only after corresponding triggering nebulizer 1) discharge preparations 2 from container 4, that is to say the preparation 2 of a dosage.Yet, delivery apparatus 5 in theory can also a certain other modes produces, provides and/or pressurize as the air of delivery media, other gases or liquid even, so that delivery formulation 2 is as the mist agent with preferred finely particulate (solid and/or liquid) or spraying mist particularly.

Nebulizer 1 preferably have one for to, particularly, extremity piece or the mouthpiece 8 of user or sufferer (not shown) delivery formulation 2.To only use term " mouthpiece " from now on.Yet this mouthpiece also can be a certain other extremity pieces for administration or delivery formulation 2, especially when nebulizer 1 is not used as inhaler.

The opening of sending of mouthpiece 8 optionally possesses grid 9 or other protective elements, special in order to can prevent for example, the damage to nebulizer 1 (, storage 3 or container 4) caused by external effect etc., and/or prevents the discharges such as other parts, larger microgranule.

Nebulizer 1 preferably has a cover 10 be associated with mouthpiece 8, with the removable cover 10 of hands, particularly so that mouthpiece 8 can be opened and close.Fig. 1 illustrates the cover 10 in closed condition (that is to say, cover mouthpiece 8).Fig. 2 is illustrated in cover 10 with similar cutaway view and opens, and that is to say, can freely approach the nebulizer 1 started in the situation of mouthpiece 8, that is to say, nebulizer 1 is ready for suction.

Particularly, cover 10 can be with indicated delivery side in Fig. 2 to 11 mobile with meeting at right angles, particularly, and slidably and/or rotatable.

In the example embodiment, cover 10 and preferably can or rotate around the pivot center rotation of the central axis 12 of the loop configurations of nebulizer 1 or storage 3 or container 4 or storage 3.Nebulizer 1 or its shell 13 be particularly with respect to axis 12 rotation-symmetric at least in fact preferably, and/or structure is at least to be essentially smooth or plate-like, particularly the shape of rounded in fact dish.Yet other geometry and structure solution and configuration are also possible.

Cover 10 preferably can or can move along the periphery of nebulizer 1 with the tangent ground movement of the shell 13 of nebulizer 1.Particularly, cover 10 and extend along periphery in fact, extend along the circumferential sectors of nebulizer 1 particularly.

Fig. 3 illustrates a preferable configuration of nebulizer 1, particularly, and one smooth, plate-like and/or circular embodiment.Same apparent, cover 10 coverings or overlapping nebulizer 1 preferably at least 90 °, the in fact about circumferential section of 150 ° to 170 ° particularly, particularly on peripheral direction and from a planar side via this circumferential section to another planar side.Yet other structure solutions and configuration are equally also possible herein.

In shown embodiment, in the fully open position shown in Fig. 2 and Fig. 3, cover 10 and preferably rotate or rotate approximately 150 ° to 180 ° with respect to the transmission location of closing shown in Fig. 1.Yet other anglecs of rotation are also possible.

Perhaps, cover 10 can be for example with the mode of slide plate and/or baffle plate form and can be for example by shell 13 or mouthpiece 8 guide, installation or fixing.

Cover 10 preferably is coupled to delivery apparatus 5, and make by opening and/or closing, and only by opening cover 10, operate or activate delivery apparatus 5 particularly, and be absorbed into delivery media by delivery apparatus 5 particularly, particularly, surrounding air.Perhaps or in addition, can by cover 10 open and/or closing movement is under pressure delivery media.Under this situation, owing to realizing intuitively the actuating of delivery apparatus 5 by opening and/or close cover 10 and particularly without any need for any additional actuated of other actuation elements, therefore operation is very simply and intuitively.

Nebulizer 1 or delivery apparatus 5 preferably have an energy storage, in shown embodiment, for the spring that is spring 14 forms, store particularly.The cover 10 preferably be coupled to energy storage so that by open and/or close the cover 10 produce powers and by energy storage in energy storage.Particularly, open and/or close, especially preferably only close cover 10 and make by back-moving spring and store or spring 14 and storage power.

Energy storage or spring store and can drive various devices and/or for different purposes, and be specifically used for driving delivery apparatus 5 or delivery media be under pressure or delivery media is shifted out from pump chambers 6, in order to discharge the preparation 2 of corresponding dosage and then make its atomization via the container transport delivery media and in wanted mode.Preferably only during delivery formulation 2 or for delivery formulation 2, delivery media is under pressure.Yet in theory, this also can occur in advance, under this situation, provide valve gear or similar device (not shown), particularly with prevent reality desired send and atomization before send too early delivery media and preparation 2.

Energy storage preferably is associated with delivery apparatus 5 or forms a part of delivery apparatus 5.Especially preferably, energy storage or spring store around delivery apparatus 5 or are configured or are incorporated in delivery apparatus 5.

In the embodiment with shown in example, after spring 14 is arranged on and extends axially or be arranged on pump chambers 6 or retractable sack 7 with respect to the direction of pump or pumping action.Under this situation, spring 14 preferably serves as Compress Spring, its compression or driving pump chamber 6 or retractable sack 7 or mobile for example piston (not shown), in order to reduce contained delivery media in the size of pump chambers 6 or compressor pump chamber 6, that is to say, delivery media is under pressure, and reaches whereby sending of delivery media.

Delivery apparatus 5 and/or energy storage especially preferred disposition, in the loop configurations of storage 3 or container 4, are configured in shell 13 center particularly so at least in fact.Preferably, delivery apparatus 5 and energy storage are configured in the zone of axis 12 or are configured and around axis 12, preferably are configured and concentric with axis 12.

According to the present invention, delivery apparatus 5 and/or energy storage or other devices are configured in and in the loop configurations of storage 3 or container 4, also make delivery apparatus 5 and/or energy storage to extend axially to exceed storage 3 or container 4, or in example transmission location as shown in FIG. 1, make delivery apparatus 5 and/or energy storage can be configured in the axial dipole field position of the principal plane of storage 3 or planar annular.

Delivery apparatus 5 and/or energy storage are configured in to the especially compact structure of atomized device 1 in the loop configurations of storage 3 or container 4 or other devices and especially lower axial height particularly.

As hereinafter be described in more detail, cover 10 rotation axis preferably corresponding to the axis 12 of the loop configurations of storage 3 or container 4, storage 3 preferably can rotate around this axis.

Nebulizer 1 preferably has a driver or gear 15, and it is specifically used for covering as mentioned above 10 and preferably is coupled to delivery apparatus 5 and/or energy storage.Perhaps or in addition, driver (hereinafter referred to gear 15) also can drive and/or activate other devices or carry out other functions.

Preferably, gear 15 partly or entirely is configured in the loop configurations of storage 3 or container 4.This promotes again the tight structure of nebulizer 1.

Gear 15 preferably drives by covering 10 motion, and directly or indirectly is coupled to particularly cover 10.

Especially preferably, by opening and/or closing movement of cover 10, gear 15 produces axially-movable with respect to loop configurations and/or axis 12 particularly.Especially preferably, axially-movable is extended or 12 extensions of paralleling to the axis on axis 12 or along axis 12.It is that at least one component of the motion that produced by gear 15 on the power outlet side extends on axial direction mentioned above that term " axially-movable " is interpreted as the meaning.

The axially-movable that can be produced by gear 15 especially be preferred for opening next container 4, for mobile and/or reach storage 3 or container 4, for back-moving spring store, for example, for activating delivery apparatus 5 (being specifically used for being absorbed into air) and/or another device (, enumerator) for activating nebulizer 1.Preferably, gear 15 has for driving the different drive ratios of different device on the power outlet side.

Gear 15 preferably includes at least one screw thread, and one rotatingly has a screw shell 16 particularly, and it especially preferably has female thread 17 and/or external screw thread 18.

Screw thread or have screw shell 16 preferably couple directly or indirectly or be connected to cover 10 and/or with the rotation axis arranged coaxial of cover 10, or form the rotation axis of cover 10.Particularly, cover 10 driving and directly cause have screw shell 16 to rotate.

In shown embodiment, delivery apparatus 5 and particularly and energy storage can preferably drive in the axial direction or activate via female thread 17 by gear 15 (particularly).Female thread 17 preferably with inside meshing part 19 engagements that comprise particularly a complementary threads part or other outthrust, mating surface etc., make the rotation of screw shell 16 cause the axially-movable of the nonrotational meshing part 19 be associated with delivery apparatus 5 or energy storage.

Particularly, spring 14 is at one end such as by means of end plate etc. and be supported on the meshing part 19 that is preferably formed corresponding spring base or bearing, and is coupled to the retractable sack 7 of delivery apparatus 5 or the movable terminal of other pumping elements at other end place.Yet different structure solutions is also still possible.Particularly, gear 15 or meshing part also can only directly act on retractable sack 7 or other pumping elements, and only indirectly are coupled in addition spring 14 or are not coupled to spring 14 fully.

From the transmission location shown in Fig. 1, when cover 10 is opened, on the one hand, meshing part 19 moves axially, that is to say, it carries out preferred axially-movable, and on the other hand, preferred chain and/or releasable connection part between meshing part 19 and delivery apparatus 5 and/or spring storage (for example, by means of at least one lock arm 20) the transmission axially-movable, and cause that particularly pump chambers 6 increases in the axial direction and preferably is absorbed into surrounding air, retractable sack 7 is pulled in the axial direction to be opened or increases, and/or preferred disposition at center or the actuation element 21 of axial arrangement be released and/or axially outwards shift out (especially when reaching the axial end position), as shown in the end position in Fig. 2.Through the spring 14 of tension, preferably with together with the axial end of meshing part 19 and retractable sack 7, move axially.

Between the follow-up period of energization of actuation element 21, particularly by radially inwardly pressing, initial send and atomization from the preparation 2 of adjacent vessel 4.Particularly, meshing part 19 on the one hand with at least one lock arm 20 between be connected or on the other hand with delivery apparatus 5 and/or energy storage between be connected particularly because at least one engaged element 22 springs at least one lock arm 20 fact of disengaged orientation (radially inside in shown embodiment) and sets up.As hereinafter discussed more in detail, spring stores or then causes that retractable sack 7 is compressed and make pump chambers 6 less through resilience or the spring force of back-moving spring 14, as its result, in pump chambers 6, contained delivery media (particularly, surrounding air) be under pressure and be moved out of, thereby preparation 2 is discharged from and atomization in wanted mode.

Replace screw thread or, except screw thread, can use in theory a certain other to control cams, slope, clinoplain or other gear drives and connect, to reach particularly motion sequence as described above, hereinafter described motion sequence and/or a certain other motion sequences.

Nebulizer 1 preferably there is a transmitting device 23 so that storage 3 can be preferably step by step or one by one container 4 ground reaches or further turn to next container 4, and preferably have a connecting device 24, it is for being connected to this container 4 severally delivery apparatus 5 and/or being specifically used for individually opening container 4 particularly.

Preferably, by covering 10 opening and/or closing, drive or activate particularly transmitting device 23 and/or connecting device 24 via gear 15.Especially preferably, reuse the axially-movable produced by gear 15.

In shown embodiment, the actuating of the actuating of transmitting device 23 and connecting device 24 (that is to say, storage 3 is moved forward to next container 4 and open next container 4 and/or be attached to delivery apparatus 5) is combined or is coupled.Yet these activate also can be controlled independently of one another or be controlled via the independent driving of gear 15 or independent drive chain particularly.

The combination of preferably, reaching transmitting device 23 and connecting device 24 by means of the external engagement parts 25 of the engagement of the external screw thread 18 with screw shell 16 is arranged (particularly via corresponding have threaded portion, slidingsurface etc.) drives.This meshing part 25 is connected to non-rotatingly specifically the storage 3 of preferred annular or is formed by storage 3.For instance, meshing part 25 can form a sealing internal ring of storage 3.Yet this meshing part 25 is not indispensable.For instance, storage 3 also can be via corresponding slidingsurface etc. and with directly engagement of gear 15 (external screw thread 18 that screw shell 16 is arranged particularly).

Storage 3 is preferably locked at its outer periphery place freely to rotate around axis 12 with screw shell 16 or external screw thread 18 are arranged preventing, particularly by the rail plate for example formed with shell 13 cooperations.

Rotation has screw shell 16 or external screw thread 18 (or other control cam) to cause non-common engagement in rotation parts 25 and the therefore axially-movable of storage 3.For instance, during cover 10 open and as the result of opening of cover 10, that is to say, by means of gear 15, the axial location of storage 3 in the transmission location shown in Fig. 1 with container 4 moves axially to the position shown in Fig. 2.In shown embodiment, on this axially-movable or the lifter motion direction contrary in the axially-movable with for activating delivery apparatus 5 (particularly, being absorbed into surrounding air), carry out but also can carry out on same direction.

Only after actuation element 21 has activated, (that is to say, after sending the preparation 2 of also atomization from container 4) and again close cover 10.Close cover 10 and screw shell 16 is rotated and cause that storage 3 carries out contrary axially-movable or lifter motion again.In this axially-movable process and/or opening in the opposite shaft orientation motion of cover during 10, rail plate causes storage 3 container 4 ground reaches or further rotate (that is to say, to next container 4) one by one.

The possible structure configuration of the preferred rail plate formed by the inwall of shell 13 of Fig. 4 a explanation or control flume or control cam 26, in order to carry out desired preferably alternately axially-movable and the storage 3 progressively further rotation of container 4 one by one of storage 3.Particularly, this aggregate motion is reached by the extension, diagonal angle that alternately axially reaches of controlling cam 26, and for example, the outthrust of storage 3 radially is engaged in this part.Yet other inner radial and/or axial means are also possible.

In shown embodiment, external engagement parts 25 and above-mentioned rail plate form transmitting device 23 or its assembly.Particularly, rail plate or transmission mechanism are constructed (reciprocal axial motion causes progressively rotation) in the mode of ball point pen mechanism.Yet other structure solutions be also possible, this structure solution causes storage 3 progressively to move forward or further rotation, especially preferably axially-movable and/or the rotation of the gear assembly by screw shell 16 is for example arranged on container 4 ground one by one particularly.

According to the alternate embodiment shown in Fig. 4 b, replace rail plate or control cam 26 or except rail plate or control cam 26, transmitting device 23 can have ratchet mechanism or the bolt latch mechanism 27 that (particularly) allows storage 3 progressively move forward or further rotate, and this storage 3 is shown in the drawings to be opened or to cut away a part.Ratchet mechanism 27 is formed between external engagement parts 25 and annular storage 3 particularly, and both can relative to each other rotate by corresponding ratchet step (ratchet step) on a direction to make this.

In shown embodiment, ratchet mechanism 27 has a ratchet 27a particularly, and transfer arm 27b can mesh in this ratchet 27a.Especially preferably, the locking radial engagement occurs.Yet on principle, engagement also can occur in the axial direction.Preferably, ratchet mechanism 27 is formed on inside and/or forms around storage 3.Transfer arm 27b can especially preferably move in an alternating manner by delivery apparatus 5 (gear 15 particularly).In shown embodiment, transfer arm 27b directly or indirectly has been connected to screw shell 16, is formed on particularly on external engagement parts 25.Preferably, transfer arm 27b towards ratchet 27a elastic biasing (particularly, by its intrinsic elasticity) to produce desired locking mesh.Especially preferably, provide a plurality of transfer arm 17b with by covering 10 or the reciprocating motion of screw shell 16 is arranged or rotate the desired reliably progressively motion obtain storage 3.

Now will be described in more detail the preferable configuration of connecting device 24.Yet, for ease of understanding, at first will be explained in more detail the preferred embodiment of storage 3.

For the structure and configuration of storage 3 and container 4, there are various probabilities.For instance, it can be optionally the foaming configuration with the combination such as carriage.Then for example by the foaming bag, form indivedual containers 4.

Especially preferably, by insert 28, form container 4, this insert 28 be contained in storage 3 preferably separately, the guide rail that radially extends particularly or take in chamber 29.Particularly, but the preferred radial displacement of each insert 28 or movement.

In shown embodiment, particularly, insert 28, take in chamber 29, mouthpiece 8 and/or delivery apparatus 11 arranged radiallys.Yet, also may there is in theory different the arrangement, for example, axially-aligned.

Take on the outer periphery that chamber 29 preferably is provided at storage 3 with opening 30 or loop configurations, when do not use or in as during state while supplying with, this opening 30 is preferably and closes, particularly sealing or otherwise be closed or cover.Reference marker 30 indications in Fig. 1 such as corresponding sealing, paper tinsel, thin film.As state while supplying with in, contain insert 28 take in chamber 29 each particularly with fluid sealing mode and also may seal with air tight manner with being hedged off from the outer world.Storage 3 is made by the non-proliferation plastics particularly and/or is optionally possessed the diffusion outer enclosure.

Each insert 28 has a storage chamber 31, the dosage that it contains specific insert 28 or preparation 2 and be filled with preparation 2 particularly during factory manufactures storage 3 or nebulizer 1.Pipeline in insert 28 or passage 32 preferably with storage chamber 31, be connected with for sending, atomization and/or remove coalescent preparation 2.Passage 32 can (if necessary) be integrated with in nozzle (not shown) or form this nozzle.In shown embodiment, therefore insert 28 is formed for the container 4 of preparation 2 with its storage chamber 31, or insert 28 is accommodated in and takes in chamber 29 or container 4 what form in storage 3 or formed by storage 3.

For delivery formulation 2, open container 4 out of the ordinary.In shown embodiment, this preferably delivery end by particularly via opening 30 by insert 28 parts out of the ordinary shift out its take in chamber 29 and preferably via opening 30 radially outward promote the sealing etc. (not shown) carry out.In this way, take in that chamber 29 or its opening 30 are opened and passage 32 exposes.For instance, (not shown) such as sealed foils of sealing respective openings 30 tears off from insert 28, or another closure or the coating member of sealing opening 30 are moved, open, release or otherwise remove from insert 28.

In shown embodiment, distinctly take in preferably moving radially preferably of chamber 29 inserts 28 and carry out by means of connecting device 24 or transmitting device 23 for opening, in the zone of the finger piece 33 by making connecting device 24 or the inner radial end of other actuated components in insert 28 out of the ordinary, axially thrust particularly particularly take in chamber 29 and particularly the desired outward radial by corresponding slidingsurface (on finger piece 33 and/or insert 28) execution insert 28 move to carry out.

For example, because storage 3 has enough thin wall or have frangible point in thrusting zone, therefore thrusting of finger piece 33 is possible.Perhaps, storage 3 also can comprise an opening etc., and it is sealed, cover or possess closure and can be opened or be thrust by finger piece 33.

Fig. 1 with the cross section on left side illustrate still close take in chamber 29, wherein insert 29 is not yet radially outward promoted.Fig. 2 be illustrated on outlet side, be opened take in chamber 29, the insert 28 wherein moved radially is outstanding from opening 30.

In this embodiment, connecting device 24 has one for container 4 out of the ordinary, setting up the Connection Element 34 be communicated with for the fluid of supplying with delivery media, make particularly and can for example (that is to say via container 4 out of the ordinary via the passage 35 of sending as by as shown in delivery apparatus 5, insert 28 out of the ordinary or its storage chamber 31) Connection Element 32 supply with delivery media, thereby for the preparation of sending each dosage and the preparation that is specifically used for each dosage of atomization.

Fluid is communicated with preferably also to be set up with respect to the axially-movable of shell 13 or Connection Element 34 by storage 3.Particularly, finger piece 33 at first axially is engaged on and distinctly takes in chamber 29 so that mobile next by the insert 28 used in the radial direction.After this radial motion, along with axially-movable continues, Connection Element 34 is engaged on to be taken in chamber 29 and is engaged in insert 28.For this reason, Connection Element 34 is configured to pierce through element particularly, for example be and there is corresponding most advanced and sophisticated intubate or the form of pin so that particularly auxiliary carry out storage chamber 31 pierce through or other thrust to set up desired fluid and are communicated with.Thereby, provide delivery media to the fluid of storage chamber 31 be communicated with and delivery media can be supplied to storage chamber 31 to discharge preparation 2.

In shown embodiment, external engagement parts 25, finger piece 33 and Connection Element 34 form connecting device 24 or its assembly.Yet, other structure solutions are possible, with for opening or pierce through with connecting this container 4 or optionally opening or sting the container 4 be through on supply side and/or on outlet side, and/or for this container 4 is connected to delivery apparatus 5, or be communicated with for the direct supply of surrounding air or another fluid of suction for for example setting up, and be specifically used for preferably radially (but optionally also axial) mobile relevant insert 28, for opening the respective openings 30 of taking in chamber 29 and/or the supply that is connected to delivery media for the storage chamber 31 by insert 28, be specifically used for Connection Element 34 is inserted in storage chamber 31.

In shown embodiment, particularly, axially-movable causes and opens, connects or pierce through via connecting device 24, preferably with the delivery side to 11 or the throughput direction of container 4 or motion or the rotation direction of storage 3 meet at right angles.Particularly, carry out and axially connect or pierce through in shown embodiment.Yet radially or other connections or also pierce through basically as possible, and (if necessary) also can be provided by means of the axially-movable that is provided by gear 15 or carry out for this.

In theory, the direction 11 that connects, opens, pierces through and/or send can radially be moved.

Especially preferably, connecting device 24 (particularly as delivery apparatus 5 and/or transmitting device 23) can by opening and/or closing, cover 10 activates and/or can activate by preferred common gear 15 or at least one axially-movable.

Another feature according to hereinafter explaining referring to alternate embodiment, also may be configured in transmitting device 23 and/or connecting device 24 in the loop configurations of storage 3 or container 4.The axial height that this promotes again the especially compact structure of nebulizer 1 and contributes to particularly to minimize nebulizer 1.

Storage 3 is preferably rigidity.Adopting term " rigidity " take to mean storage 3 or its to take in chamber 29 is preferably formed for the holder of enough stablizing or well defining of insert 28 and may is guide rail.Yet other structure solutions are possible.For instance, by externally guiding storage 3 or distinctly take in chamber 29, may reaching, take in will guiding of contained insert 28 in chamber 29, even for example storage 3 is not rigid construction.Perhaps or in addition, for connecting container 4, maybe when opening while taking in chamber 29, or, in order to send each dosage, can remove insert 28 fully from storage 3.Under this situation, particularly, storage 3 also can for example only be configured to blister pack or other encapsulation.

Fig. 2 illustrates the nebulizer 1 in starting state.Surrounding air is inhaled in pump chambers 6.Spring 14 is tightened up.The container 4 of selecting for sending next dosage has been opened and has connected, and corresponding insert 28 has radially outward been promoted and be connected to by means of Connection Element 34 (being pierced through by Connection Element 34 particularly) supply of delivery media.

In shown embodiment, the actual delivery of taking in preparation contained in chamber 29 2 or dosage through piercing through and particularly atomization after only can corresponding triggering or further activate (for example, cover 10 another or further activate after) but as the result of actuation element 21, occur particularly, actuation element 21 is preferably only axially outwards mobile under this state, is axially inwardly pressed and is activated by user or sufferer (not shown) particularly.This latch or other mesh components, make spring store or spring 14 can relax.Delivery media in pump chambers 6 is under pressure and is delivered to via sending passage 35 and Connection Element 34 and connects in storage chamber 31.Delivery media continues to flow through passage 32 and flows out insert 28, and in storage chamber 31, contained preparation 2 is discharged from simultaneously.The agent of gained mist or spray cloud are sent via mouthpiece 8 via selecting grid 9, make user or sufferer to suck to have sent and the preparation 2 of atomization particularly.

The nebulizer 1 of (that is to say,, container 4 lax at spring 14 is empty and covers 10 and still open in situation) after Fig. 5 illustrates suction with schematic cross-sectional.

After sucking or after delivery formulation 2, again close cover 10.This completes particularly on contrary rotation direction.Due to provided coupling (particularly, by means of gear 15), inner meshing part 19 moves back into it in the axial direction again in the original position shown in Fig. 1, spring storage simultaneously or spring 14 are strained again, and finally re-establish that the operation between storing of meshing part 19 and delivery apparatus 5 or spring is connected or other axially connect (particularly via latch walls 20), make spring 14 relax and in the situation that meshing part 19 be connected and re-establish the original position shown in Fig. 1 with will keep between retractable sack 7 and/or spring 14 particularly.In addition, storage 3 moves back into its axial home position, that is to say, is axially promoted back in the opposite direction.Particularly, this discharges storage 3 from finger piece 33 and from Connection Element 34.

When connecting device 24 (its finger piece 33 and Connection Element 34 particularly) no longer is engaged in storage 3 but allows desired rotational motion, storage 3 reach or the further rotation of container one by one preferably is superimposed upon in axially-movable, and this (that is to say, opening and/or the down periods of cover 10) and occurs all the time during cover 10 move up and down.In shown embodiment, rail plate or control cam 26 therefore preferably through design make storage 3 one by one container 4 to move forward or further rotate the only part in axially-movable during occur.

Measure described above obtain having particularly a small amount of assembly nebulizer 1 very closely, simple structure.

The nebulizer 1 proposed can very simply and intuitively operate.In essence, operation nebulizer 1 is needed only for opening and cut out cover 10.The all functions of imagination or process are triggered whereby or control or automatically occur.Except the actuating of cover 10, when nebulizer 1 is configured to active nebulizer 1, it triggers actual delivery and atomization after only remaining on and opening cover 10.This preferably completes by activating (pressing particularly) actuation element 21.Because actuation element 21 only is preferably, at nebulizer 1, be activated (that is to say, cover 10 and be opened) afterwards actuatable, axially shift out and/or can approach, therefore make simple intuitive operation become and may and get rid of maloperation.

Actuation element 21 is particularly by the opening in cover 10.Yet different embodiments is equally also possible herein.In addition, actuation element 21 also may can be approached (for example, appearing by covering 10) in the starting state of nebulizer 1.

After suction, can again close nebulizer 1 or cover 10.Preferably, as long as actuation element 21 not yet activated, that is to say, in shown embodiment still in axially extended position, or oneself be opened connect or container 4 delivery formulations 2 that pierce through before, cover 10 against closure and fastening.

Fig. 3 illustrates in opening or the nebulizer proposed 1 of starting state.Therefore cover 10 rotates approximately 160 ° to 180 ° with respect to the transmission location of closing shown in Fig. 1.Preferably can be only in the opposite direction rotating mask 10 to open and to close cover 10.Therefore rotating retainer 36 preferably is provided, and it gives prominence to from periphery or shell 13 as seen and for example from the outside in shown embodiment.This contributes to guarantee simply and intuitively operating of nebulizer 1, because user is understood cover 10 intuitively, must open or close how many and open or close in which direction.Especially preferably, nebulizer 1 structure make rotating retainer 36 be formed for cover 10 in open mode and also for the retainer of the cover 10 in closed condition.Perhaps, also can provide for this purpose independent outthrust or retainer.

Nebulizer 1 or cover 10 and preferably also comprise the locking device 37 shown in Fig. 4 c (partial cross section of the nebulizer 1 in starting state), it guarantees only alternately to open and close cover 10.For this purpose, such as axially providing at least one corresponding breech lock 38 etc. up and down or between the zone of the cover 10 of front and back configuration and shell 13 each other, functional to provide.

Preferably, nebulizer 1 or locking device 37 are included in the control loop 39 illustrated separately with perspective view in Fig. 4 d.Control loop 39 its axially or planar side there is tooth or breech lock 38 on both.Reach as shown in Figure 1, Figure 2 shown in Fig. 4 c, control loop 39 is guided in circular passage in nebulizer 1 or its shell 37 etc. particularly in a rotatable manner.

As indicated in Fig. 4 c, in shell side is locked and determined breech lock 38 that arm 40a is engaged on control loop 39, during on the cover side, lock arm 40b is engaged on another breech lock 38 simultaneously.Breech lock 38 matches each other so that covering 10 initially only can move in one direction or rotate with respect to shell 13 with lock arm 40a and 40b, and therefore by locking device 37 or by lock arm 40a or 40b, works in the opposite direction and prevent rotation in the opposite direction.

Preferably, provide a plurality of lock arm 40a on shell 13, it is engaged in the associated breech lock 38 of control loop 39 and allows control loop 39 only to rotate in one direction with respect to nebulizer 1 or shell 13.Therefore, preferably also on cover 10, configure some lock arm 40b or some lock arm 40b are associated with cover 10, and this lock arm 40b allows control loop 39 only rotating on a rotation direction with respect to cover 10.

For guaranteeing that covering 10 only alternately opens or closes fully, control loop 39 is with respect to shell 13 or cover 10 and only may rotation in one direction under any situation can alternately be blocked and if only if arrive end position out of the ordinary (that is to say, in fully open position or fully closed position) time and restart or release.Hereinafter will be referring to another cross section brief explanation control loop 39 of the nebulizer 1 according to Fig. 4 e with respect to shell 13 or cover this locking of 10.

Form the retainer 40c as shown in Fig. 4 d on control loop 39, it is cooperated with the stopper arms 40d as shown in Fig. 4 e.Fig. 4 e illustrates the locking of control loop 39 to prevent the rotation with respect to shell 13 with example.Carry out this locking with correspondence or similar fashion between cover 10 and control loop 39, and this is locked in during covering 10 reverse motions with respect to shell 13 and works.

In above-mentioned locking, at least one retainer 40c hits at least one stopper arms 40d, make control loop 39 also be blocked with respect to the rotation of shell 13, control loop 39 may enter not in the rotation direction of lock arm 40a and 38 blocking-up of associated breech lock thereof with respect to the rotation of shell 13 originally.Keep this by the blocking-up of stopper arms 40d, until cover 10, to move to its end position.

When arriving end position, the control inclined-plane or the slidingsurface 40e that are formed on cover 10 cause stopper arms 40d springing, make the retainer 40c of previous blocking-up now be released, and therefore cover 10 and can return with respect to control loop 39 and therefore also rotate in the opposite direction or move.Simultaneously, at this end position, another retainer 40c (not shown in Fig. 4 e) of control loop 39, in abutting connection with the stopper arms 40d be configured on cover 10, blocks the relative turnability of control loop 39 with respect to cover 10 whereby.As a result, cover 10 now can only rotate in the opposite direction or move until arrive other end position together with control loop 39.In other end position, correspondingly again block the rotation of control loop 39 with respect to shell 13, and to cover 10 turnability with respect to control loop 39 be again freely.Therefore, cover 10 and only alternately open or close fully, in order to guarantee simply and operation intuitively or activate and particularly so that the operation of debug.

Shown embodiment illustrates active nebulizer 1.Yet in theory, nebulizer 1 also can be configured to the passive type nebulizer.Under this situation, can save delivery apparatus 5 and/or energy storage or spring and store.Instead, for instance, can during sucking, by respiratory movement, be absorbed into surrounding air, and by this air via container 4 out of the ordinary (particularly, the access portal 30 of the insert 28 of taking in chamber 29 and using) be delivered to mouthpiece 8, make in wanted mode and send or discharge and atomization preparation 2.

If necessary, also can be independent of delivery apparatus 5 and the storage of use spring, for example, for moving forward and/or opening or closing container 4, be specifically used for driving and/or activate transmitting device 23 and/or conveyer device 24.

If nebulizer 1 does not have delivery apparatus 5 and/or energy storage, can omit actuation element 21 and needed actuating except mobile cover 10 (that is to say the actual release of preparation 2 and the additional triggers of atomization).More suitably, then preferably be enough to open cover 10 in order to start nebulizer 1, make that next container 4 is ready to be directly used in and to suck and suck and can occur immediately with its dosage or preparation 2.

Mouthpiece 8 is preferably fixture construction and/or arranged radially and/or preferably is formed directly on shell 13.This is had the simple and tight structure of the nebulizer 1 of (particularly) level and smooth at least in fact exterior contour.Yet mouthpiece 8 also can be movably in theory, for example, collapsible, slidably, telescopically extends or can a certain other modes move.Perhaps or in addition, mouthpiece 8 also can be in different directions (for example, diagonally or axially) arranges or is configured to for delivery formulation 2 or mist agent.

The nebulizer 1 proposed preferably comprises an enumerator (not shown) in addition.

The preferred Purely mechanical operation of the nebulizer 1 proposed.

The nebulizer 1 proposed preferably only is comprised of plastic assembly or part at least in essence, or at least only is made of plastics in essence.If necessary, only spring 14 and optionally grid 13 can be made of metal.

According to another feature, also can omit in the first embodiment particularly by pressing effectively sending and the manual activation of atomization of preparation 2 that actuation element 21 carries out.Instead, preferably provide the actuating by breathing to control.For instance, when by breathing, in nebulizer 1, producing corresponding vacuum, can not set up inner meshing part 19 on the one hand with the spring 14 of biasing between fixing be connected or on the other hand with retractable sack 7, another conveying or pumping element etc. between fixing be connected, so that make preparation 2 to send and particularly the atomization of preparation 2 (that is to say, by means of being stored in energy storage or the spring energy in storing) can be during sucking occurs in fact automatically.

Some extra embodiments of proposed nebulizer 1 hereinafter will be described, difference or the new aspect wherein only emphasizing to compare with the first embodiment in essence.Therefore the explanation provided in above and annotation are preferably still with its original meaning application or to augment or the similar type application.

Fig. 6 and Fig. 7 illustrate the schematic diagram of the second embodiment of proposed nebulizer 1.Fig. 6 is illustrated in container 4 and does not pierce through nebulizer in the closed position in situation 1.It is opened or pierce through the nebulizer in starting state 1 in situation that Fig. 7 is illustrated in container 4.

In the second embodiment, form contrast with the first embodiment, storage 3 can not move axially.Instead, connecting device 24 preferred axes are to slidably or removable.In shown embodiment, by rotatable inner body 41, carry out fixing storage 3.Connecting device 24 (at least its Connection Element 34 and preferably its finger piece 33) is arranged on axially movable but non-rotatable carriage 42.Carriage 42 is preferably axially movable by opening and/or cut out cover 10 (particularly by means of not detailed illustrated gear 15) herein again.

Carriage 42 preferably has axial work tooth 43, such as the axial work tooth 43 with class sawtooth slidingsurface etc., it is with 44 cooperations of the complementation that provides on inner body 41 or form or corresponding matching tooth and be engaged on particularly and coordinate in tooth 44 so that the axially-movable of carriage 42 cause inner body 41 and storage 3 through define, progressively further rotation.

In the second embodiment, carriage 42 on inner body or around inner body and preferably coordinate along periphery with storage 3, and with carriage 42, above the end face of the inner body 41 of the outside around storage 43 extends to the other end of storage 3 and radially inwardly is back to, be formed with particularly preferred axial tooth 43 internal edge mode and coordinate.Carriage 42 has a peripheral openings 45, and it at least is positioned on the extension of the special container 4 that has been opened or has pierced through or the insert 28 radially moved forward, so that sending of preparation 2 can be carried out and not get clogged in starting state.

In the second embodiment, use the operation sequence identical with operation sequence in the first embodiment.

Fig. 8 with schematic cross-sectional illustrate in opening, the 3rd embodiment of the nebulizer proposed 1 of starting state.The 3rd embodiment major part is corresponding to the second embodiment, but connecting device 24 also is not so good as the planar side covered from the annular flange flange by inner body 41 in the second embodiment but is engaged in storage 3 and (utilizes particularly finger piece 33 and Connection Element 34) from contrary planar side.

Fig. 9 is to illustrate source in the 4th embodiment of the nebulizer proposed 1 of transmission location or lock-out state.

Cover 10 herein for the hat formula.The rotation axis of cover 10 configures prejudicially or forms, and configures particularly or is formed in the periphery or marginal area of nebulizer 1.Form contrast with previous embodiment, cover 10 and only cover in essence mouthpiece 8.

In the 4th embodiment, cover 10 other Function Coupling with nebulizer 1 of opening and/or close preferably not.

Nebulizer 1 has a relieving mechanism 46, and it is configured to the slide plate that can move along periphery particularly.

Figure 10 illustrates the nebulizer 1 in unlocked state with schematic cross-sectional.

In the 4th embodiment, nebulizer 1 has can axially movable toward each other two preferred outer enclosure parts, upper case part 47 and lower case part 48 particularly.Particularly, as shown in Figure 10, the preferably biasing away from each other by a plurality of spring elements 49 of casing part 47,48, make in non-locking and non-compressed state, and upper case part 47 axially raises with respect to lower case part 48.

Two casing parts 47,48 can be with together with the power of spring element 49 moves axially on the contrary.In the axial compression state, breech locked is together particularly for two casing parts 47,48.This breech lock can discharge by activating relieving mechanism 46.

From the transmission position, after release, by spring element 49, automatic axial moves away from lower case part 48 to upper case part 47.This causes the actuating of delivery apparatus 5 away from motion or lifter motion, that is to say the increase of pump chambers 6 and the suction of surrounding air.In addition, the spring 14 be associated with delivery apparatus 5 (its retractable sack 7 particularly) is whereby by axial tightening or compression.Therefore spring element 21 has the spring force that is greater than spring 14.

In addition, above-mentioned axially-movable or lifter motion cause that the actuation element 41 be associated with spring 14 axially raises or shifts out.

In addition, axially lifter motion causes that storage 3 moves axially and separates with connecting device 24 (not illustrating in detail).

Then, user (not shown) must be with together with the power of spring element 49 manually axially promotes two casing parts 47,48 on the contrary.During this axially-movable and/or formerly, during lifter motion, storage 3 is container 4 ground rotations one by one further.The further rotation of storage 3 or reach are preferably carried out by the slidably control of transmitting device 23 etc. again.Along with process continues, the container 4 turned in delivery apparatus then is opened and preferably is connected to conveyer device via connecting device 24 (not shown) herein again.

Figure 11 is illustrated in the starting state that promotes the nebulizer 1 of gained after together, wherein casing part 47,48 breech locks or lock together and actuation element 21 axially outstanding.Preferably, only when reaching this state or only after being opened, cover 10 just likely activates on actuation element 21 the sending and atomization from the preparation of the dosage through opening container 4 with permission.

By activating (particularly, axially be pressed into) actuation element 21, the blocking-up of retracting spring 14, make spring 14 axially to relax and to activate whereby delivery apparatus 5, make particularly air pressurized contained in pump chambers 6, make this air via attached container 4, carry and in wanted mode via mouthpiece 8 delivery formulations 2.

The 4th embodiment also allows the very operation of simple, intuitive.Prevent maloperation by suitable blocking-up member particularly.

Figure 12 to Figure 14 illustrates the 5th embodiment of the nebulizer proposed 1 of the various states in the they's state corresponding to shown in Fig. 9 to Figure 11.

The 5th embodiment and the 4th embodiment difference in essence be, container 4 or insert 28 open, pierce through and/or the mobile and/or direction of aiming at respect to the axis 12 of storage 3 or container 4 or loop configurations at least in fact axially or extend in parallel but not radially extend.In shown embodiment, mouthpiece 8 therefore configure or be formed on storage 3 tops at nebulizer 1 or shell 13 (under this situation, the upper case part 47 particularly) side on, simultaneously mouthpiece 8 in fact with the planar side of nebulizer 1 ground or vertically outstanding or stretch out that meets at right angles.

In the 5th embodiment, from the transmission location shown in Figure 12, at first, cover 10 and must open, and, in shown embodiment, they preferably can be around axis 12 rotations of tangential extension.Only approach relieving mechanism 46 as cover 10 Shi Caike that have been opened.Other aspect programs are identical with the program of the 4th embodiment.

Figure 15 illustrates the 6th embodiment of the nebulizer proposed 1 in transmission location with schematic cross-sectional.The 6th embodiment is similar to the 4th embodiment on principle particularly.Yet different from previous embodiment, the 6th embodiment does not have delivery apparatus 5.More suitably, it is passive type nebulizer 1.

In transmission location, axially movable two casing parts 47 and 48 are particularly by least one snap fit hook 50 etc. and breech lock or lock together away from each other.After this at least one snap fit hook 50 can preferably be engaged on the annular shoulder 51 on another casing part 47,48 etc., so that the chain fixing be formed in latched position in the axial direction between two casing parts 47,48 connects.

In the 4th embodiment, preferably provide a plurality of spring elements 49.In the 6th embodiment, the only central spring element 49 formed by the central spiral spring particularly preferably is provided, this central spring element 49 supports two casing parts 47 and opens in 48 minutes.As shown in Figure 16, under this situation, when activating central relieving mechanism 46 by axial compressive force particularly, at least one snap fit hook 50 grades are jumped out, that is to say, do not form the breech lock of two casing parts 47 and 48, make two casing parts 47 and 48 to move axially away from each other.As the result of this lifter motion, storage 3 preferably further rotates a container 4.Away from motion or axially-movable, due to the spring force of spring element 49, automatically occur.This axially-movable preferably is converted to again desired, the progressively rotational motion of storage 3 by gear or tooth, rail plate etc. (not shown).Preferably, the ball point pen mechanism of previously mentioning also can start to work herein.Simultaneously, as the result away from motion, the container 4 that the Connection Element 34 of connecting device 24 has been emptied between can a comfortable upper delivery period separates.

Then, with the power of spring element 49 on the contrary by together with two casing parts, 47,48 Manual press.In this way, spring element 49 is again strained and is connected or open next container 4 by connecting device 24 (its Connection Element 34 particularly).Finally, as shown in Figure 15, at least one snap fit hook 50 is again automatically locking two casing parts 47 and 48 together in promoting end position together.

Now can be sucked.In the 6th embodiment, as the Connection Element 34 in Figure 17 is schematically indicated by arrow 54, by breathing, user or sufferer (not shown) produce that entrance 52 via Connection Element 34 is delivered in the container 4 of opening or piercing through and are passed to the air-flow of mouthpiece 8 via the outlet 53 of Connection Element 34 with together with preparation 2 from container 4.

In the 6th embodiment, the container 4 used is preferably also axially opened or pierces through.For instance, indicated in details as shown in Figure 18 particularly, storage 3 is configured to comprise the foaming ring (not shown) of a plurality of foaming bags herein, or is configured to particularly have a plurality of preferred axes for taking in foaming ring (not shown) or foaming bag loop bracket 55 to the dimple 56 of opening.In shown embodiment, particularly, storage 3 directly forms or is fixedly attached to particularly lower case part 48 by lower case part 48.

The 6th embodiment preferably includes a blocking vessel 57, and it blocks further and activates after all containers 4 have been used or have been emptied, and blocks particularly further opening or the motion of casing part 47 and 48 of nebulizer 1.Blocking vessel 57 for example forms the hook on storage 3, associated inner body 41 or loop bracket 55, and for example be engaged in the bearing 58 formed on upper case part 47 when arriving blocking position, make two casing parts 47 and 48 can not move axially again separately.This blocking-up is also preferably irreversible.Figure 18 illustrates in the position that casing part still is separated from each other in it.

Be similar to other embodiments, the 6th embodiment preferably includes an enumerator 59, in shown embodiment, this enumerator 59 preferably include one on storage 3 (particularly, on the outer periphery of storage 3 or lower case part 48) corresponding scale 60, and one in shell 13 the corresponding window 61 of (particularly, in upper case part 47).The relative rotation position of storage 3 is corresponding to being used or the number of operational container 4 still.Therefore, scale 60 can be indicated the still number of the available or container 4 that has been used.Figure 19 illustrates enumerator 59 to excise a part of side view.

Figure 20 illustrates the nebulizer 1 in unlocked state (that is to say, in the axial rising situation of upper case part 47) with the view corresponding to Figure 19.In this position, storage 3 has preferably been moved axially and has made scale 60 invisible with respect to window 61.Instead, preferably how a symbol (arrow etc.) particularly operates on it to illustrate to user through indication, that is to say optionally by two casing parts 47 and 48 are pressed together.On this aspect, enumerator not only is used for counting but also having the operation of the nebulizer 1 of another function auxiliary block post proposition.

As indicated in Figure 15 and Figure 16, according to the nebulizer 1 of the 6th embodiment, can there is central authorities or the axial dimple 62 in shell 13 or upper case part 47.This dimple 62 can be used for additional functionality or device.

Figure 21 illustrates the alternate embodiment of the nebulizer 1 that has clock 63 or have time measurement device.Clock 63 be preferably mounted in dimple be incorporated in addition nebulizer 1 or its shell 13 in.Making that clock 63 is constructed particularly can be sent preferred optics, acoustics and/or vibration signal to remind user to use nebulizer 1.

Figure 22 illustrates another alternate embodiment had for the nebulizer 1 of the sealed chamber of (not shown) such as medicaments or other containers.Particularly, dimple 62 structure to hold medicament etc. and can for example seal by lid 64 or other closures.

Figure 23 illustrates the 8th embodiment in the nebulizer proposed 1 of transmission location (that is to say, close in situation at cover 10) with schematic cross-sectional.The 8th embodiment is the passive type nebulizer 1 that is similar to the nebulizer 1 in the 7th embodiment.Yet, by rotation or rotary cover 10, open and close and activate on nebulizer 1 principle corresponding to the first to the 3rd embodiment.

In the 8th embodiment, storage 3 and connecting device 24 are constructed as the 7th embodiment in essence.Connecting device 24 or its Connection Element 34 are axially movable by by means of gear (not illustrating in detail), opening and close cover 10.In transmission location, connecting device 24 or its Connection Element 34 move axially away from storage 3.

By opening cover 10 (rotation preferably approximately reaches 180 °), at first move forward or further rotate storage 3, and, along with axially-movable continues, by connecting device 24, piercing through by Connection Element 34 particularly or other attached next container 4 of opening.Figure 24 illustrates this starting state with schematic cross-sectional.

When user or sufferer (not shown) while being breathed to suck, generation is the air flow by container 4 or storage chamber 31 (such as the bag etc. that foams) via Connection Element 34, and in this way via connecting contained preparation 2 in mouthpiece 8 discharges delivery container 4.

For permitting simple and cheap structure, entrance 52 and export 53 and preferably form by common assembly, form by single-piece Connection Element 34 particularly.In addition, Connection Element 34 preferably also has an exit passageway 65 that is adjacent to outlet 53 and broadens with funnel shaped or other suitable methods particularly.Therefore, do not need the mouthpiece 8 on conventional sense or be generally used for extension of inhaler etc.More suitably, the correspondence that has shell aperture and (if necessary) shell 13 is shaped be enough in case be formed for user or sufferer (not shown) closely, joint space-efficient mouthpiece 8.

Figure 25 illustrates a schematic diagram, and its explanation is according to the transmitting device 23 of the nebulizer 1 of the 8th embodiment.Particularly, tooth 44 is (particularly movingly for axial tooth 43 on the storage side and the axially-displaceable on shell side, together with connecting device 24) cooperate, in order to reach storage 3 desired progressively reach or the further rotation of container 4 one by one, wherein to coordinate tooth 44 to be associated with opening of cover 10 with respect to each axially-movable of tooth 43.Particularly, previously mentioned ball point pen principle starts to work again.

Yet, other structure solutions are also possible, so that the motion (particularly, certainly opening and/or close derivative rotatablely moving and/or axially-movable) of opening and/or closing that has concurrently by cover 10 is reached the desired progressively reach of storage 3 or further rotates.

Form contrast with the 7th embodiment, in the 8th embodiment, enumerator 59 preferred disposition are on the planar side or axial side of nebulizer 1, and window 61 is formed in cover 10 and reaches in shell 13 particularly, make preferably the current state of read-out counter all the time, even when closing cover 10.

Equally in the 8th embodiment, storage 3 also preferably possesses a loop bracket 55 for fixing foaming configuration (foaming ring etc.) particularly.Yet, basically can use the storage 3 of any wanted type herein, even there is particularly the storage 3 of the insert 28 that is used to form container 4.

Due to needed only for opening cover 10 in order to start nebulizer 1 (that is to say, for atomization or suck ready), therefore the 8th embodiment allows especially shirtsleeve operation.Even, after atomization or sucking, also do not need other operation bidirectionals.More suitably, only be necessary to close nebulizer 1 or cover 10.When closing cover 10 the time, connecting device 24 or its Connection Element 34 move axially away from storage 3 or the container 4 opened recently, make and recover the transmission location shown in Figure 23.

Figure 26 illustrates the schematic basic representation of height of concept of the 9th embodiment of proposed nebulizer 1.The 9th embodiment relates to and has the active nebulizer 1 that the delivery apparatus 5 of preferred disposition in the loop configurations of storage 3 or container 4 and energy storage or spring store, container 4 in Figure 26 only by taking in chamber 29 indications.

In the 9th embodiment, delivery apparatus 5 also preferable configuration is pump and possesses particularly retractable sack 7, retractable sack 7 for pumping in the radial direction on delivery apparatus 5 preferably movably, extensible and scalable or compressible specifically.After spring storage or spring 14 preferably are configured in retractable sack 7 on this pumping direction, be configured in particularly on the side away from connecting device 24.

Figure 26 is illustrated in the spring in bias state in retractable sack 7 extension situations and stores or spring 14.Under this state, by delivery apparatus 5 or retractable sack 7, be absorbed into surrounding air.

Delivery apparatus 5 with spring storage preferably can the slide plate mode move.Next by the container 4 used for opening, at first radially move forward delivery apparatus 5 and connecting device 24 or Connection Element 34, make next container 4 or next insert 28 radially be pierced through or connected and radially outward moved by delivery apparatus 5.This state is illustrated in schematically showing in Figure 27.Then activate and occur.By making in the radial direction spring 14 lax, compression retractable sack 7, and in retractable sack 7, contained air flows through Connection Element 34 and attached container 4 (attached insert 28 particularly), as its result, contained preparation 2 in amount discharge container 4 or insert 28.Then, can again radially recall particularly delivery apparatus 5 and/or connecting device 24 by radial motion.In addition, because radial motion spring 14 is setovered again, wherein retractable sack 7 extensions and delivery media (being air) are inhaled in retractable sack 7 herein.Fastening or the breech lock of spring 14 is in offset position, fastening or be latched to slide plate particularly.

Utilize contrary radial motion, next container 4 or insert 28 can be pierced and radially outward promote particularly to open its sealing out of the ordinary.During this radial motion, spring 24 keeps compression or tension and retractable sack 7 to keep extending.Therefore, reach the starting state of nebulizer 1.

Preferably, utilize the actuating of actuation element (not shown), spring 14 is through discharging in order to compress retractable sack 7, that is to say in order to actuated pump, make compressed delivery media (that is to say air) be forced through insert 28 to send or discharge or atomization or remove the preparation 2 of coalescent each dosage and produce will spraying of preparation 2.

The part of radial motion preferably, also with so that storage 3 points to or moves to next container 4, that is to say to activate transmitting device 23.

In the 9th embodiment, transmitting device 23 is preferably particularly via pinion 66 inner engagement on storage 3, and this pinion 66 preferably is engaged in the internal tooth 67 of storage 3.

Have to be noted that connecting device 24 and pump 5 are preferably formed a unit or interconnection.

Connection Element 34 is connected to slide plate and/or pump 5 and/or retractable sack 7.

In the 9th embodiment, container 4/ is taken in chamber 29 formation and is arranged on the preferred independent part on preferred class ring carriage 55 with fit form and/or rigid manner particularly.Take in chamber 29 or container 4 preferably by distinctly seal and/or preferably at least seal separately or individually (not shown in Figure 26 and Figure 27) on its exterior periphery periphery.

Figure 28 with similarly very schematically basic representation the tenth embodiment of the nebulizer 1 proposed is shown.The tenth embodiment relates to the 9th embodiment and is similar to particularly the 9th embodiment, and configuration and/or the function aspects at delivery apparatus 5 and connecting device 24 is similar to the 9th embodiment best, and does not therefore need the explanation to these.

Figure 29 illustrates with Figure 28 and forms the nebulizer according to the tenth embodiment 1 that contrast has shell 13 and preferred rotatable or rotatable cover 10 with schematic cross-sectional.

The tenth embodiment allows (particularly) to cover 10 rotation or rotational motion and is converted to linearity and/or radial motion in order to activate delivery apparatus 5 and/or connecting device 24, best so that mobile link element 34.Particularly, to slide and/or automatically gear-drivenly couple or control.

In shown embodiment, nebulizer 1 has at least one control element 68, and it is constructed in dish mode (comparing with Figure 28) particularly.Control element 68 preferably is coupled to rotationally cover 10 (in shown embodiments, via the axial engagement 69 as indicated in Figure 29) or for example forms by cover element 10.

Especially preferably, control element 68 forms a rail plate or some rail plates, so as with wanted or the mode of necessity activates (particularly) delivery apparatus 5 and connecting device 24 or its Connection Element 34.Yet, also may use in theory independent control element 68, rail plate and/or other gear drives to connect, to control and to activate on the one hand delivery apparatus 5 and to control on the other hand and activate connecting device 24 or its Connection Element 34, and/or the different sections for moving.

In shown embodiment, provide the first control cam or rail plate 70 for connecting device 24 or pass through delivery apparatus 5 and/or preferred linearity or the radial motion of the slide plate 79 that connecting device 24 forms.For this purpose, particularly, the first engaged element 71 is engaged in the first rail plate 70.Preferably, the first engaged element 71 is rigidly connected to connecting device 24 or its Connection Element 34 directly or indirectly.

The first rail plate 70 is shown in Figure 28 is opening.Yet it also can be particularly dimple as shown in Figure 29, groove etc.

The path of the first rail plate 70 is determined that gear drive couples or determined also can be along circumference and/or the linear movement of radially extending and the dependence of rotational motion.In shown embodiment, the first rail plate 70 comprises the first section 72 extended on circumference particularly, the second preferred linear segments 73 of connection and/or the second section 73 with radial component, and/or the 3rd section 74 again extended on circumference particularly.

Therefore, between cover 10 period of energization, that is to say, during cover 10 rotates the position shown in Figure 28 and Figure 29 (closed position or transmission location), at first, during the first section 72, do not have linearity or the radial motion of connecting device 24 or slide plate 79.In shown embodiment, slide plate 79 or connecting device 24 only occur further along linearity or the radial motion of the second section 73, make Connection Element 34 contact with next container 4, be engaged on particularly in next container 4 or next insert 28, being created in best delivery apparatus 5 or Connection Element 34 is communicated with the fluid between storage chamber 31, and optionally by the insert 28 that radially moves forward, move it by opening 30 particularly, in order to open opening 30.Nebulizer 1 presents enable position.

At the self closing status transition to during starting state, delivery apparatus 5 or spring store or spring 14 preferably in tension.Therefore, actuation element 21 now can activated, make particularly by making lock arm 20 deflections and retracting spring 14 or retractable sack 7 compressor pump chamber 6 and delivery formulation 2 whereby, as its result, preparation 2 is discharged or is sent by delivery media and atomization particularly in wanted mode, as previously explained.

In shown embodiment, cover 10 or control element 68 preferably be used for activating delivery apparatus 5 simultaneously, in order to bias spring, store or spring 14 particularly.For this purpose, control element 68 comprises the second control cam or rail plate 75, the second engaged element 76 and this second control cam or rail plate 75 cooperations, particularly, in shown embodiment, second control cam or rail plate 75 and delivery apparatus 5 spring stores or spring 14 (particularly, spring 14 radially or linear removable bearing 77) be associated, or directly or indirectly firmly be connected to delivery apparatus 5 or spring stores or spring 14.

Especially preferably, slidably or with on delivery apparatus 5 or the mode of the slide plate on slide plate 79 guide bearing 77, slide plate 79 again with the mode of slide plate in the direction of motion (under this situation, radial direction) on slidably, and fixing or carrying connecting device 24 or its Connection Element 34 particularly.

Figure 29 illustrates the spring 14 (under this situation, compressed state) in offset position.Bearing 77 is by means of lock arm 20 at least and be immobilizated in offset position.In shown embodiment, the second rail plate 75 preferable configuration so that in closed position or transmission location, spring store or spring 14 fastening non-desired lax to prevent by the shoulder 78 of the radial motion in this position blocking-up the second engagement 76 particularly.

When actuation element 21 activated, lock arm 20 does not complete to extrinsic deflection or locking mesh, and lax spring stores or spring 14 or triggering delivery apparatus 5.Then, spring 14 is in previous described mode, in shown embodiment with linear mode or compressing in the radial direction retractable sack 7 or pump chambers 6.Therefore, as explained referring to other embodiments, then send and the hang oneself container 4 that connects or the preparation 2 (not shown in Figure 28 and Figure 29) of the insert 28 through connecting of atomization particularly.

Between relaxation period, the second engaged element 76 moves (and optionally exceeding) towards nebulizer 1 or control element 68 center or towards the pivot center of cover 10 particularly.The second rail plate 75 is through correspondingly freely cutting to allow this motion.In shown embodiment, the radial segment 80 along the second rail plate 75 on this motion essence is extended.

In shown embodiment, particularly cover 10 close or travelling backwards during, control element 68 returns or spring stores or spring 14 again in tension.

Position travelling backwards in control element 68 self-starting states or (preferably with respect to the position in Figure 28 and Figure 29, rotate 90 ° to 180 °) while returning, maintenance section 81 by the second rail plate 75 stops bearing 77 via the second engaged element 76 on a certain section of the contrary radial motion of slide plate 79 or the first engaged element 71, make in this section of motion, spring stores or spring 14 is biased again and retractable sack 7 extends again, particularly until by means of lock arm 29, breech lock occurs.Between this moving period, Connection Element 34 is preferably recalled at least in part from attached container 4 or attached insert 28 simultaneously.

During further linearity or radial motion, delivery apparatus 5, connecting device 24, Connection Element 34 and slide plate 79 together with spring 14 travelling backwards of biasing to the original position shown in Figure 28 and Figure 29.

In shown embodiment, above-mentioned motion sequence is particularly by closing cover 10 and making control element 68 return to carry out with closing to be associated.

Figure 29 illustrates preferred annular storage 3 with pure schematic form again.In conjunction with this figure, can be with reference to particularly about the annotation of other embodiments.

During the rotation of opening motion and/or closing movement or control element 68 of cover 10, in the tenth embodiment, not shown transmitting device 23 preferably can activated in order to make storage 3 move forward to next container 4.This couples etc. by means of corresponding or suitable gear drive particularly and completes.For instance, as explained before, can carry out moving axially of storage 3 for this purpose, move forward by means of execution such as preferred control cams 26 on shell side in a circumferential direction or particularly.Particularly or or, as using in other embodiments particularly the gear drive by means of screw thread to couple.

But the individual characteristics of indivedual embodiments and aspect be combination with one another also, as required or use in other structures of nebulizer, inhaler, dispensing device etc.

In the present invention, preferably should explain very widely term " nebulizer " in order to comprise other delivery apparatus, dispensing device etc., simultaneously preparation 2 or other media or fluid only need be when being required atomization and optionally can also multi-formly sending.

Hereinafter list some preferred composition and/or compositionss of preferred pharmaceutical formulation 2.As mentioned, it is in particular powder or liquid in broad sense.Especially preferably, preparation 2 contains following each material:

Hereinafter listed compound can himself or combination for apparatus of the present invention.Hereinafter in mentioned compound, W is pharmacological active substance and for example is selected from following material: β analogies (betamimetics), anticholinergic, corticosteroid, PDE4-inhibitor, LTD4-antagonist, EGFR-inhibitor, dopamine agonist, H1-antihistaminic, PAF-antagonist and PI3-inhibitors of kinases.In addition, dual or three recombinations of W can be through combination and for apparatus of the present invention.The combination of W for example may be:

-W means the combination of β analogies and anticholinergic agents, corticosteroid, PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W means the combination of anticholinergic agents and β analogies, corticosteroid, PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W means the combination of corticosteroid and PDE4-inhibitor, EGFR-inhibitor or LTD4-antagonist,

-W means the combination of PDE4-inhibitor and EGFR-inhibitor or LTD4-antagonist,

-W means the combination of EGFR-inhibitor and LTD4-antagonist.

Preferably, it as the compound of β analogies, is the compounds that are selected from following: albuterol, Ah's formoterol (arformoterol), bambuterol, bitolterol, broxaterol, carbuterol, clenbuterol, fenoterol, formoterol, hexoprenaline, ibuterol, neoisuprel, isoproterenol, levosalbutamol, Mabuterol, meluadrine, orciprenaline, orciprenaline, pirbuterol, procaterol, reproterol, rimiterol, ritodrine, Salmefamol, salmaterol, soterenol (soterenol), Suo Fenteluo (sulphonterol), terbutaline, tiaramide, special sieve (tolubuterol) of special infectious coryza, zinterol (zinterol), CHF-1035, HOKU-81, KUL-1248, and

3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-benzyl-sulfonamide

5-[2-(5,6-diethyl-indane-2-base amino)-1-hydroxyl-ethyl]-8-hydroxyl-1H-quinoline-2-one-

4-hydroxyl-7-[2-{[2-{[3-(2-phenyl ethoxy) propyl group] sulfonyl } ethyl]-amino } ethyl]-2 (3H)-benzothiazolones

1-(the fluoro-4-hydroxy phenyl of 2-)-2-[4-(1-benzimidazolyl)-2-methyl-2-butyl amino] ethanol

1-[3-(4-methoxy-benzyl-amino)-4-hydroxy phenyl]-2-[4-(1-benzimidazolyl)-2-methyl-2-butyl amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-N, N-dimethylaminophenyl)-2-methyl-2-propyl amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-methoxyphenyl)-2-methyl-2-propyl amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-[3-(4-normal-butyl oxygen base phenyl)-2-methyl-2-propyl amino] ethanol

1-[2H-5-hydroxyl-3-oxo-4H-1,4-benzoxazinyl-8-yl]-2-{4-[3-(4-methoxyphenyl)-1,2,4-triazole-3-yl]-2-methyl-2-butyl amino } ethanol

5-hydroxyl-8-(1-hydroxyl-2-isopropylamino butyl)-2H-1,4-benzoxazinyl-3-(4H)-one

1-(the chloro-5-trifluoromethyl of 4-amino-3-)-2-tert-butyl group amino) ethanol

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-methoxyl group-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [Isosorbide-5-Nitrae] oxazine-one

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-phenoxy group-acetic acid ethyl ester)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-phenoxy group-acetic acid)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

8-{2-[1,1-dimethyl-2-(2,4,6-trimethylphenyl)-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-hydroxyl-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

6-hydroxyl-8-{1-hydroxyl-2-[2-(4-isopropyl-phenyl)-1,1-dimethyl-ethylamino]-ethyl }-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

8-{2-[2-(4-ethyl-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

8-{2-[2-(4-ethyoxyl-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

4-(4-{2-[2-hydroxyl-2-(6-hydroxyl-3-oxo-3,4-dihydro-2H-benzo [Isosorbide-5-Nitrae] oxazine-8-yl)-ethylamino]-2-methyl-propyl group }-phenoxy group)-butanoic acid

8-{2-[2-(the fluoro-phenyl of 3,4-bis-)-1,1-dimethyl-ethylamino]-1-hydroxyl-ethyl }-6-hydroxyl-4H-benzo [Isosorbide-5-Nitrae] oxazine-3-ketone

1-(4-ethyoxyl-carbonylamino-3-cyano group-5-fluorophenyl)-2-(tert-butyl group amino) ethanol

2-hydroxyl-5-(1-hydroxyl-2-{2-[4-(2-hydroxyl-2-phenyl-ethylamino)-phenyl]-ethylamino }-ethyl)-benzaldehyde

N-[2-hydroxyl-5-(1-hydroxyl-2-{2-[4-(2-hydroxyl-2-phenyl-ethylamino)-phenyl]-ethylamino }-ethyl)-phenyl]-Methanamide

8-hydroxyl-5-(1-hydroxyl-2-{2-[4-(6-methoxyl group-biphenyl-3-base amino)-phenyl]-ethylamino }-ethyl)-the 1H-quinoline-2-one-

8-hydroxyl-5-[1-hydroxyl-2-(6-phenethyl amino-hexyl amino)-ethyl]-the 1H-quinoline-2-one-

5-[2-(2-{4-[4-(2-amino-2-methyl-propoxyl group)-phenyl amino]-phenyl }-ethylamino)-1-hydroxyl-ethyl]-8-hydroxyl-1H-quinoline-2-one-

[3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-5-methyl-phenyl]-urea

4-(2-{6-[2-(the chloro-benzyloxy of 2,6-bis-)-ethyoxyl]-hexyl amino }-1-hydroxyl-ethyl)-2-hydroxymethyl-phenol

3-(4-{6-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-hexyl oxygen base }-butyl)-benzsulfamide

3-(3-{7-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-heptyl oxygen base }-propyl group)-benzsulfamide

4-(2-{6-[4-(3-Pentamethylene. sulfonyl-phenyl)-butoxy]-hexyl amino }-1-hydroxyl-ethyl)-2-hydroxymethyl-phenol

N-diamantane (obsolete)-2-base-2-(3-{2-[2-hydroxyl-2-(4-hydroxyl-3-hydroxymethyl-phenyl)-ethylamino]-propyl group }-phenyl)-acetamide,

Optional with the form of its racemic modification, enantiomer or diastereomer or optionally with the acceptable acid-addition salts of its pharmacology, solvate or hydrate forms.According to the present invention, the acid-addition salts of β analogies is preferably selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, methane sulfonates, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Spendable preferred anticholinergic preferably is selected from: tiotropium (Tiotropium) salt is preferably bromide salt; Oxygen holder ammonium (Oxitropium) salt, be preferably bromide salt; Fluorine holder ammonium (Flutropium) salt, be preferably bromide salt; Ipratropium (Ipratropium) salt, be preferably bromide salt; GLYCOPYRRONIUM (Glycopyrronium) salt, be preferably bromide salt; Trospium cation (Trospium) salt, be preferably chloride salt, i.e. tolterodine (Tolterodin).In salt referred to above, pharmacologically active is partly cation.Anion can be preferably chloride ion, bromide ion, iodide ion, sulfate radical, phosphate radical, Loprazolam root, nitrate anion, maleate, acetate, citrate, fumaric acid radical, tartrate anion, oxalate, amber acid radical, benzoate anion or p-methyl benzenesulfonic acid root, simultaneously chloride ion, bromide ion thing, iodide ion, sulfate radical, Loprazolam root or the preferred counter ion counterionsl gegenions of p-methyl benzenesulfonic acid root.With regard to all salt, chloride, bromide, iodide and methane sulfonates are especially preferred.

Other preferred anticholinergic are the salt that is selected from formula AC-1,

X wherein ^-indication has the anion of single negative charge, preferably be selected from the anion in following: fluorion, chloride ion, bromide ion, iodide ion, sulfate radical, phosphate radical, the Loprazolam root, nitrate anion, maleate, acetate, citrate, fumaric acid radical, tartrate anion, oxalate, amber acid radical, benzoate anion and p-methyl benzenesulfonic acid root, be preferably the anion with single negative charge, especially be preferably selected from following anion: fluorion, chloride ion, bromide ion, Loprazolam root and p-methyl benzenesulfonic acid root, especially be preferably bromide ion, optionally be racemic isomer, the form of enantiomer or hydrate.The person of being even more important is those medicine combinations of the enantiomer that contains formula AC-1-en

X wherein ^-can there is implication mentioned above.Other preferred anticholinergic are the salt that is selected from formula AC-2

Wherein R means methyl or ethyl, and wherein X-can have implication mentioned above.

In substituting embodiment, the form that formula AC-2 compound can also free alkali AC-2-alkali exists.

AC-2-alkali

Other concrete compounds are:

2,2-diphenyl-propionic acid tropine alcohol ester Methobromide,

2,2-diphenyl-propionic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

2-is fluoro-2,2-diphenyl acetic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

2-is fluoro-2,2-diphenyl acetic acid tropine alcohol ester Methobromide,

3,3 ', 4,4 '-tetrafluoro diphenylglycollic acid tropine alcohol ester Methobromide,

3,3 ', 4,4 '-tetrafluoro diphenylglycollic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

4,4 '-difluorodiphenyl glycolic tropine alcohol ester Methobromide,

4,4 '-difluorodiphenyl glycolic Di(2-thienyl)glycolic acid scopine ester. Methobromide,

3,3 '-difluorodiphenyl glycolic tropine alcohol ester Methobromide,

3,3 '-difluorodiphenyl glycolic Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid tropine alcohol ester Methobromide,

The fluoro-fluorenes of 9--9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

The fluoro-fluorenes of 9--9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-methyl-fluorenes-9-carboxylic acid tropine alcohol ester Methobromide,

9-methyl-fluorenes-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

Diphenylglycollic acid cyclopropyl hyoscyamine ester Methobromide,

2,2-diphenyl-propionic acid cyclopropyl hyoscyamine ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-methyl-fluorenes-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-methyl-xanthene-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

9-hydroxyl-fluorenes-9-carboxylic acid cyclopropyl hyoscyamine ester Methobromide,

4,4 '-difluorodiphenyl glycolic cyclopropyl hyoscyamine methyl ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-methyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-methyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide,

9-ethyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-difluoromethyl-xanthene-9-carboxylic acid tropine alcohol ester Methobromide,

9-hydroxymethyl-xanthene-9-carboxylic acid Di(2-thienyl)glycolic acid scopine ester. Methobromide.

Compound mentioned above also can be used as salt and uses within the scope of the invention, and wherein, except Methobromide, these salt can be used methyl-X, and wherein X can have above the implication given for X-.

As corticosteroid, preferably use the compound be selected from following:

Beclometasone, betamethasone, budesonide, butixocort, ciclesonide, deflazacort, dexamethasone, Ai Puruinuo, flunisolide, fluticasone, loteprednol, mometasone, prednisolone, prednisone, rofleponide, triamcinolone, RPR-106541, NS-126, ST-26 reach

The fluoro-17-[(2-furyl carbonyl of 6,9-bis-) oxygen base]-11-hydroxyl-16-methyl-3-oxo-androstane-Isosorbide-5-Nitrae-diene-17-thiocarbonic acid (S)-methyl fluoride ester

The fluoro-11-hydroxyl of 6,9-bis--16-methyl-3-oxo-17-propionyloxy-androstane-Isosorbide-5-Nitrae-diene-17-thiocarbonic acid (S)-(2-oxo-tetrahydrochysene-furan-3S-yl) ester

6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxo-17 α-(2,2,3,3-tetramethyl cyclopropyl carbonyl) oxygen base-androstane-Isosorbide-5-Nitrae-diene-17 β-carboxylic acid cyano methyl ester

It optionally is racemic form, as enantiomer, diastereomer, or is optionally the form of the upper acceptable salt of pharmacology and derivant, solvate and/or hydrate.Corticosteroid comprises any salt or derivant, hydrate or the solvate that may exist.Possible salt and the example of derivant are alkali metal salt (for example sodium salt or potassium salt), sulfonic benzoic acid salt, phosphate, nicotimine hydrochlorate, acetate, dichloroacetate, propionate, dihydric phosphate, palmitate, pivalate or furoate.

Spendable PDE4-inhibitor preferably is selected from the compound among following material: enprofylline, theophylline, roflumilast, Ai Ruifu (cilomilast), TOEFL department special (Tofimilast), pumafentrine, Li Ruisite (Lirimilast), arofylline, if Ah 's agate, D4418, Bay-198004, BY343, CP-325366, D-4396 (Sch-351591), AWD-12-281 (GW-842470), NCS-613, CDP-840, D-4418, PD-168787, T-440, T-2585, V-11294A, C1-1018, CDC-801, CDC-3052, D-22888, YM-58997, Z-15370 reaches

N-(the chloro-1-oxo-pyridin-4-yl of 3,5-bis-)-4-difluoro-methoxy-3-cyclo propyl methoxy Benzoylamide,

(-) p-[(4aR ^*, 10bS ^*)-9-ethyoxyl-1,2,3,4,4a, 10b-six hydrogen-8-methoxyl group-2-methyl benzo [s] [1,6] benzodiazine-6-yl]-N, N-diisopropyl Benzoylamide

(R)-(+)-1-(4-benzyl bromide)-4-[(3-cyclopentyloxy)-4-methoxyphenyl]-2-Pyrrolidone

3-(cyclopentyloxy-4-methoxyphenyl)-1-(4-N '-[N-2-cyano group-S-methyl-isothiourea group] benzyl)-2-Pyrrolidone

Along [4-cyano group-4-(3-cyclopentyloxy-4-methoxyphenyl) cyclohexane extraction-1-carboxylic acid]

2-carbomethoxy-4-cyano group-4-(3-cyclo propyl methoxy-4-difluoro-methoxy phenyl) hexamethylene-1-ketone

Along [4-cyano group-4-(3-cyclo propyl methoxy-4-difluoro-methoxy phenyl) hexamethylene-1-alcohol]

(R)-(+)-ethyl [4-(3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine-2-subunit] acetas

(S)-(-)-ethyl [4-(3-cyclopentyloxy-4-methoxyphenyl) pyrrolidine-2-subunit] acetas

9-cyclopenta-5,6-dihydro-7-ethyl-3-(2-thienyl)-9H-pyrazolo [3,4-c]-1,2,4-triazol [4,3-a] pyridine

9-cyclopenta-5,6-dihydro-7-ethyl-3-(tert-butyl group)-9H-pyrazolo [3,4-c]-1,2,4-triazol [4,3-a] pyridine,

The optional form with its racemic modification, enantiomer or diastereomer, or optionally with the acceptable acid-addition salts of its pharmacology, solvate and/or hydrate forms.According to the present invention, the acid-addition salts of PDE4-inhibitor is preferably freely following each salt of choosing: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

The LTD4-antagonist used preferably is selected from the compound in following material: montelukast, pranlukast, zafirlukast, MCC-847 (ZD-3523), MN-001, MEN-91507 (LM-1507), VUF-5078, VUF-K-8707, L-733321 reach

1-(((R)-(3-(2-(the fluoro-2-quinolyl of 6,7-bis-) vinyl) phenyl)-3-(2-(2-hydroxyl-2-propyl group) phenyl)-sulfenyl)-methyl-cyclopropane-acetic acid

(((((2-(2 for 3-in 1 (R)-3 for 1-, the 3-dichloro-thiophene is [3,2-b] pyridine-5-yl also)-(E)-vinyl) phenyl)-3-(2-(1-hydroxyl-1-methyl-ethyl) phenyl) propyl group) sulfenyl) methyl) cyclopropane-acetic acid

[2-[[2-(the 4-tert-butyl group-2-thiazolyl)-5-benzofuranyl] oxygen ylmethyl] phenyl]-acetic acid

The optional form with its racemic modification, enantiomer or diastereomer, or optional form, solvate and/or hydrate forms with the acceptable acid-addition salts of its pharmacology.Acid-addition salts according to the present invention is preferably and is selected from each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.The salt of LTD4-antagonist or derivant optionally form alkali metal salt (for example sodium salt or potassium salt), sulfonic benzoic acid salt, phosphate, nicotimine hydrochlorate, acetate, propionate, dihydric phosphate, palmitate, pivalate or furoate.

Spendable EGFR-inhibitor preferably is selected from the compound in following material: Cetuximab, trastuzumab, ABX-EGF, Mab ICR-62 reach

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-diethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-[(S)-(oxolane-3-yl) oxygen base]-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{[4-((R)-2-methoxy-6-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[2-((S)-6-methyl-2-oxo-morpholine-4-yl)-ethyoxyl]-7-methoxyl group-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-(N, N-is two-(2-methoxyl group-ethyl)-amino)-1-oxo-2-butylene-1-yl] amino }-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-ethyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-[N-(tetrahydropyran-4-base)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclo propyl methoxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-((R)-oxolane-3-base oxygen base)-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-((S)-oxolane-3-base oxygen base)-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-[N-(2-methoxyl group-ethyl)-N-methyl-amino]-1-oxo-2-butylene-1-yl } amino)-7-cyclopentyloxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N-cyclopropyl-N-methyl-amino)-1-oxo-2-butylene-1-yl] amino }-7-cyclopentyloxy-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-[(R)-(oxolane-2-yl) methoxyl group)-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-[(S)-(oxolane-2-yl) methoxyl group)-quinazoline

4-[(3-acetenyl-phenyl) amino]-6,7-pair-(2-methoxyl group-ethyoxyl)-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-7-[3-(morpholine-4-yl)-propyl group oxygen base]-6-[(vinyl-carbonyl) amino]-quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-(4-hydroxyl-phenyl)-7H-pyrrolo-[2,3-d] pyrimidine

The chloro-4-fluorophenyl of 3-cyano group-4-[(3-) amino]-6-{[4-(N, N-dimethylamino)-1-oxo-2-butylene-1-yl] amino }-7-ethoxy yl-quinoline

The chloro-4-of 4-{[3-(the fluoro-benzyloxy of 3-)-phenyl] amino }-6-(5-{[(2-methane sulfonyl-ethyl) amino] methyl }-furan-2-yl) quinazoline

4-[(R)-(1-phenyl-ethyl) amino]-6-{[4-((R)-6-methyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-methoxyl group-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-{[4-(morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-7-[(oxolane-2-yl) methoxyl group]-quinazoline

The chloro-4-fluorophenyl of 4-[(3-) amino]-6-(4-[N, N-pair-(2-methoxyl group-ethyl)-amino]-1-oxo-2-butylene-1-yl } amino)-7-[(oxolane-2-yl) methoxyl group]-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-{[4-(5,5-dimethyl-2-oxo-morpholine-4-yl)-1-oxo-2-butylene-1-yl] amino }-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-[(R)-(oxolane-2-yl) methoxyl group]-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-7-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-6-[(S)-(oxolane-2-yl) methoxyl group]-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{2-[4-(2-oxo-morpholine-4-yl)-piperidin-1-yl]-ethyoxyl }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[1-(tert-butyl group oxygen base carbonyl)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-methane sulfonyl amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(tetrahydropyran-3-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the 6-{1-[(methoxy) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(piperidines-3-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[1-(2-acetyl-amino-ethyl)-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(tetrahydropyran-4-base oxygen base)-7-ethyoxyl-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-((S)-oxolane-3-base oxygen base)-7-hydroxyl-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-methoxyl group-ethyoxyl)-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the trans-4-[(dimethylamino of 6-{) sulfuryl amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the trans-4-[(morpholine of 6-{-4-yl) carbonylamino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the trans-4-[(morpholine of 6-{-4-yl) sulfuryl amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-acetyl-amino-ethyoxyl)-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(tetrahydropyran-4-base oxygen base)-7-(2-methane sulfonyl amino-ethyoxyl)-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the 6-{1-[(piperidin-1-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-amino carbonyl methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-{N-[(tetrahydropyran-4-base) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-{N-[(morpholine-4-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-{N-[(morpholine-4-yl) sulfonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-ethane sulfuryl amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-ethyoxyl-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-(2-methoxyl group-ethyoxyl)-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[1-(2-methoxyl group-acetyl group)-piperidin-4-yl oxygen base]-7-(2-methoxyl group-ethyoxyl)-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-acetyl-amino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-[1-(tert-butyl group oxygen base carbonyl)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(tetrahydropyran-4-base oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-{N-[(piperidin-1-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-{N-[(4-methyl-piperazine-1-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the cis-4-[(morpholine of 6-{-4-yl) carbonylamino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[2-(2-oxo-pyrrolidine-1-yl) ethyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-(2-methoxyl group-ethyoxyl)-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-acetyl group-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-methyl-piperidin-4-yl oxygen base)-7-(2-methoxyl group-ethyoxyl) quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-isopropyl oxygen base carbonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(cis-4-methylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the cis-4-[N-of 6-{ (2-methoxyl group-acetyl group)-N-methyl-amino]-hexamethylene-1-base oxygen base }-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-(piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-[1-(2-methoxyl group-acetyl group)-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

4-[(3-acetenyl-phenyl) amino]-6-{1-[(morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(is cis-2,6-dimethyl-morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(2-methyl-morpholine-4-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(S, S)-(2-oxa--5-aza-bicyclo [2.2.1] heptan-5-yl) carbonyl]-piperidin-4-yl oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(N-methyl-N-2-methoxy ethyl-amino) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-ethyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the 6-{1-[(2-methoxy ethyl) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-{1-[(3-methoxy-propyl-amino) carbonyl]-piperidin-4-yl oxygen base }-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the cis-4-of 6-[(N-methane sulfonyl-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the cis-4-of 6-[(N-acetyl group-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-methylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-the trans-4-of 6-[(N-methane sulfonyl-N-methyl-amino)-hexamethylene-1-base oxygen base]-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-dimethylamino-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(trans-4-{N-[(morpholine-4-yl) carbonyl]-N-methyl-amino }-hexamethylene-1-base oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-[2-(2,2-dimethyl-6-oxo-morpholine-4-yl)-ethyoxyl]-7-[(S)-(oxolane-2-yl) methoxyl group]-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-methane sulfonyl-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline

The fluoro-phenyl of the chloro-4-of 4-[(3-) amino]-6-(1-cyano group-piperidin-4-yl oxygen base)-7-methoxyl group-quinazoline,

Optional with the form of its racemic modification, enantiomer or diastereomer and optionally with the acceptable acid-addition salts of its pharmacology, solvate or hydrate forms.According to the present invention, these acid-addition salts preferably are selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

The dopamine agonist used preferably is selected from the compound in following material: bromocriptine, cabergoline, α-dihydro ergocryptine (α-Dihydroergocryptine), lisuride, pergolide, pramipexole, Roxindole, ropinirole, talipexole, terguride and dimension are praised (Viozane), it optionally is racemic form, for enantiomer, diastereomer, or be optionally pharmacology upper acceptable salt, solvate or hydrate.According to the present invention, these acid-addition salts are preferably and are selected from following each salt: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, methane sulfonates, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Spendable H1-antihistaminic preferably is selected from the compound in following material: epinastine, cetirizine, azelastine, fexofenadine, levocabastine, loratadine, mizolastine, can be how for fragrant (Ketotifen), emedastine, dimetindene, clemastine, bamipine, dexchlorpheniramine (Cexchlorpheniramine), pheniramine, doxylamine, chlorphenoxamine, dimenhydrinate, diphenhydramine, promethazine, ebastine, ground Loratadine (Desloratidine) and meclizine, it optionally is racemic form, as enantiomer, diastereomer, or be optionally the upper acceptable salt of pharmacology, solvate or hydrate.According to the present invention, these acid-addition salts are preferably freely following each salt of choosing: hydrochlorate, hydrobromate, hydriodate, sulfate, phosphate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalates, succinate, benzoate and tosilate.

Also can use as EP1 003,478A1 or CA2, the disclosed macromole that sucks in 297,174A1.

In addition, described compound can be selected from the derivant of following each material: the derivant of peptide, triptan (triptane), CGRP-antagonist, phosphodiesterase-V-inhibitor, it optionally is racemic modification, enantiomer, diastereomeric form, and optional its pharmacology upper acceptable acid-addition salts, solvate and/or hydrate.

The example of peptide derivant is dihydroergotamine and Ergotamine.

Claims (26)

1. A nebulizer (1) for delivering a formulation (2) from a reservoir (3) having an arrangement of multiple containers (4) in which each containing a dose of the formulation (2), The nebulizer (1) has a delivery device (5) for delivering the delivery medium of the formulation (2), and spring storage, Wherein the nebuliser (1) is configured such that the delivery medium can be pressurized by the spring storage in order to deliver the formulation (2). 2. A nebuliser as claimed in claim 1, characterized in that the delivery means (5) comprises or forms a pump. 3. The nebulizer according to claim 1, characterized in that the delivery device (5) comprises a bellows (7) for delivering the delivery medium. 4. A nebuliser as claimed in claim 1, characterized in that the energy store is associated with or forms part of the delivery device (5). 5. The nebuliser according to claim 3, characterized in that the energy storage or spring storage surrounds the delivery device (5), or is configured or integrated in the delivery device (5), or is positioned in a telescopic After the capsule (7). 6. The nebulizer according to claim 1, characterized in that the nebulizer (1) comprises a conveying device (23) for progressively advancing the reservoir (3) so as to be able to be emptied successively The container (4) thus aerosolizes the individual doses. 7. The atomizer as claimed in claim 6, characterized in that the reservoir (3) has teeth meshing with the transmission means (23) for moving or rotating the reservoir (3), In order to move the container (4) forward. 8. The nebuliser as claimed in claim 1, characterized in that the reservoir (3) is configured as a rigid ring. 9. The nebulizer according to claim 1, characterized in that the nebulizer (1) comprises a fixed and radially guided end piece or mouthpiece (8) for delivering the preparation (2). 10. The nebulizer according to claim 1, characterized in that the nebulizer (1) has a centrally located and/or axially depressible actuating element (21) for triggering a dose A delivery of the formulation (2). 11. The nebuliser as claimed in claim 1, characterized in that the nebuliser (1) has a counter (59) for indicating the dose which has been dispensed or is still available. 12. The nebulizer according to claim 1, characterized in that the nebulizer (1) has connection means (24) for continuously connecting the container (4) to the delivery device (5) And/or open the container (4) to inhale individual doses. 13. The nebuliser as claimed in claim 12, characterized in that the direction (11) of connection, opening and/or delivery extends radially. 14. The nebuliser as claimed in claim 13, characterized in that the delivery device (5) and/or the connection device (24) are movable by means of a sliding rail (70, 75). 15. The nebulizer according to claim 12, characterized in that, a plurality of containers (4) are arranged in an annular shape, and the delivery device (5), the energy storage and/or the connecting device (24) are arranged in the annular arrangement. configuration. 16. The nebulizer according to claim 12, characterized in that the delivery device (5), the energy storage and/or the connection device (24) are movable together. 17. The nebulizer according to claim 1 or 13, characterized in that the nebulizer (1) is configured as a portable inhaler. 18. The atomizer as claimed in claim 1 or 13, characterized in that the atomizer (1) is flat in construction. 19. A nebulizer according to claim 1 or 13, characterized in that the nebuliser (1) comprises a reservoir (3). 20. The atomizer according to claim 1, characterized in that each of the containers (4) comprises an insert (28) with individual doses, the containers (4) are constructed as separate parts, and/ Or arranged on a common or annular bracket (55), and/or independently sealed, and/or sealed on its outer circumferential periphery. 21. A nebuliser as claimed in claim 20, characterized in that each container (4) is sealed by a metal or plastic foil. 22. The atomizer according to claim 20 or 21, characterized in that each container (4) has two opposite openings (30), and each insert (28) can be supplied via a pressurized An opening ( 30 ) for gas is connected and the individual doses can be dispensed via a further opening ( 30 ) or can be pushed at least partially outwardly from the container ( 4 ) via a further opening ( 30 ). 23. A nebuliser as claimed in claim 20 or 21, characterized in that each insert (28) can be pushed through a respective seal of the associated container (4) to break the seal. 24. A nebuliser as claimed in claim 20 or 21, characterized in that each insert (28) is at least partially movable or pushed outwardly from the respective container (4). 25. The nebulizer according to claim 20 or 21, characterized in that each insert (28) comprises a storage chamber (31) containing the respective dose, each insert (28) comprises at least one A conduit or channel (32) through which the nebulized formulation (2) is injected directly during use. 26. A nebuliser as claimed in claim 1 or 13 or 20 or 21 above, wherein the delivery medium is air.

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