CN101428165A - Physiotherapy equipment for treating peripheral nerve pathological changes of diabetes - Google Patents
Physiotherapy equipment for treating peripheral nerve pathological changes of diabetes Download PDFInfo
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Abstract
一种治疗糖尿病周围神经病变的理疗仪,属医疗器械的技术领域,包括电源1、智能控制器2、按键接口3、数码显示器4、极性控制电路5、脉冲控制电路6、自检电路7、第一升压变压器8和输出电极9和机壳10,利用两个线圈的互感作用,产生方向相反的感应电流,并使用双表面电极在局部形成回路,产生低频率正弦波,模仿肌肉生物电的刺激的频率与强度,从而改善局部组织的血液、淋巴循环,调节人体生物电流的正常运转,创造周围神经修复的微环境,起到加速神经轴索生长与雪旺氏细胞增殖的作用,建立针对糖尿病周围神经病变的新治疗模式。
A physical therapy instrument for treating diabetic peripheral neuropathy, belonging to the technical field of medical devices, including a power supply 1, an intelligent controller 2, a button interface 3, a digital display 4, a polarity control circuit 5, a pulse control circuit 6, and a self-test circuit 7 1. The first step-up transformer 8, the output electrode 9 and the casing 10 use the mutual inductance of the two coils to generate an induced current in the opposite direction, and use the double-surface electrodes to form a loop locally to generate a low-frequency sine wave, imitating muscle biology The frequency and intensity of electrical stimulation can improve blood and lymphatic circulation in local tissues, regulate the normal operation of human bioelectricity, create a microenvironment for peripheral nerve repair, and accelerate the growth of nerve axons and the proliferation of Schwann cells. Establishment of a new treatment paradigm for diabetic peripheral neuropathy.
Description
技术领域 technical field
本发明涉及一种治疗糖尿病周围神经病变的理疗仪,属医疗器械的技术领域。The invention relates to a physical therapy instrument for treating diabetic peripheral neuropathy, belonging to the technical field of medical devices.
背景技术 Background technique
糖尿病的发病率逐年增高,目前全球糖尿病患者已超过2亿,预计到2025年这一数字将增加到3.5亿。糖尿病慢性并发症是导致糖尿病患者残疾和死亡的重要原因,每年有20万人死于糖尿病相关的并发症,已成为威胁人类健康的第三大疾病。糖尿病周围神经病变是糖尿病最常见的慢性并发症之一,统计显示,80%~100%的糖尿病患者通过神经功能详细检查发现存在不同程度的周围神经病变。患者可出现疼痛、麻木、烧灼、针刺感等症状,严重干扰睡眠,降低了生活质量。The incidence of diabetes is increasing year by year. At present, there are more than 200 million diabetics in the world, and this number is expected to increase to 350 million by 2025. Chronic complications of diabetes are an important cause of disability and death in diabetic patients. Every year, 200,000 people die from diabetes-related complications, which has become the third major disease that threatens human health. Diabetic peripheral neuropathy is one of the most common chronic complications of diabetes. Statistics show that 80% to 100% of diabetic patients have various degrees of peripheral neuropathy through detailed neurological examination. Patients may experience pain, numbness, burning, acupuncture and other symptoms, which seriously interfere with sleep and reduce the quality of life.
电刺激治疗是目前公认的治疗周围神经病变的有效方法之一,市场上已有的理疗仪多采用简易电子控制,以低频振荡、调压倍频或变压器升压技术产生高压直流电脉冲刺激,实现电刺激治疗的目的,存在的不足主要是:1、直流脉冲刺激强度大,覆盖范围小,随刺激深度的增加而刺激强度增加,容易出现灼伤;2、脉冲强度不稳定,调节为跳跃式增减,患者治疗时常产生不适感;3、人机对话的智能化功能弱,难以准确调节和设置;4、缺少电路自检功能,不能校正理疗仪工作状态;5、电路运行与静态功耗较大,装置体积和重量大,不利于移动;6、供临床所用的刺激波繁多,但缺少针对针对疾病的个体化治疗的模式,不适当电刺激带来较大的治疗风险。在我国,制造机构与研究机构还未能制造出治疗糖尿病周围神经病变的理疗仪。Electric stimulation therapy is currently recognized as one of the effective methods for the treatment of peripheral neuropathy. Most of the existing physiotherapy instruments on the market use simple electronic control to generate high-voltage direct current pulse stimulation with low-frequency oscillation, voltage regulation and frequency multiplication, or transformer boosting technology to achieve The purpose of electrical stimulation therapy, the main shortcomings are: 1. The DC pulse stimulation intensity is large, the coverage is small, and the stimulation intensity increases with the increase of the stimulation depth, which is prone to burns; 3. The intelligent function of man-machine dialogue is weak, and it is difficult to adjust and set accurately; 4. The circuit self-test function is lacking, and the working status of the physical therapy instrument cannot be corrected; 5. The circuit operation and static power consumption are relatively low. 6. There are many stimulation waves for clinical use, but there is a lack of individualized treatment modes for diseases, and inappropriate electrical stimulation brings greater treatment risks. In my country, manufacturing institutions and research institutions have not been able to produce a physical therapy instrument for the treatment of diabetic peripheral neuropathy.
发明内容 Contents of the invention
本发明的目的是克服现有技术不足,提供一种治疗糖尿病周围神经病变的便携式理疗仪,利用两个线圈的互感作用,产生方向相反的感应电流,并使用双表面电极在局部形成回路,产生低频率正弦波,模仿肌肉生物电的刺激的频率与强度,从而改善局部组织的血液、淋巴循环,调节人体生物电流的正常运转,创造周围神经修复的微环境,起到加速神经轴索生长与雪旺氏细胞增殖的作用,建立针对糖尿病周围神经病变的新治疗模式。The purpose of the present invention is to overcome the deficiencies of the prior art and provide a portable physiotherapy instrument for treating diabetic peripheral neuropathy. The mutual inductance of two coils is used to generate induced currents in opposite directions, and the double-surface electrodes are used to locally form a loop to generate Low-frequency sine waves imitate the frequency and intensity of muscle bioelectric stimulation, thereby improving the blood and lymph circulation of local tissues, regulating the normal operation of human bioelectricity, creating a microenvironment for peripheral nerve repair, and accelerating the growth and development of nerve axons. The role of Schwann cell proliferation to establish a new treatment model for diabetic peripheral neuropathy.
为了实现上述目的,本发明采用以下技术方案,现结合附图说明如下。In order to achieve the above object, the present invention adopts the following technical solutions, which are described below in conjunction with the accompanying drawings.
一种治疗糖尿病周围神经病变的理疗仪,包括电源1、智能控制器2、按键接口3、数码显示器4、电源开关S8和机壳10,电源1由三个直流稳压电源组成,三个直流稳压电源的稳压输出端分别为+5伏端、—5伏端和VCC端,VCC端的输出电压为+9伏,三个直流稳压电源的公共点接地线,智能控制器2是单片机,在单片机内部的存储器中存有指挥和命令单片机的CPU执行下列操作的程序,所述操作计有:接受按键接口3传来的按键信号、驱动数码显示器4显示按键信号的含意、输出按键信号要求输出的信号,智能控制器2的P00端与A点连接,智能控制器2的P26端与B点连接,智能控制器2的WR端与C点连接,智能控制器2的P27端与D点连接,智能控制器2的P17端与E点连接,智能控制器2的INT1端与F点连接,智能控制器2的INT0端与G点连接,按键接口3包括七个按键,它们是选择治疗设定键S1、治疗强度增加键S2、治疗强度减小键S3、治疗时间增加键S4、治疗时间减小键S5、治疗开始键S6、治疗停止键S7,数码显示器4包括三个显示屏,它们是选择显示屏LCD1、治疗强度显示屏LCD2和治疗时间显示屏LCD3,按键接口3、数码显示器4、电源开关S8安装在机壳的顶面上,其特征在于:它还包括极性控制电路5、脉冲控制电路6、自检电路7、第一升压变压器8和输出电极9,极性控制电路5包括第一电阻R15、第二电阻R16、第一电容C5、第一非门U8A、第二非门U8B、第三非门U8D、第四非门U8C、第一晶体管Q2和第二晶体管Q3,脉冲控制电路6包括第三电阻R117、第一电位器POT1、第二电容C6、第三电容C7、第四电容C4、第一二极管D101、第二二极管D102、第一DA转换器U3、第二DA转换器U4、第一运算放大器U5A、第二运算放大器U6A、第三运算放大器U5B和第三晶体管Q1,自检电路7包括第四电阻R26、第五电阻R25、第六电阻R24、第七电阻R23、第八电阻R21、第九电阻R22、第十电阻R29、第十一电阻R20、第十二电阻R19、第五电容C8、第三二极管D103、第一比较器U7A、第二比较器U7B、第三比较器U7C和第四比较器U7D,升压变压器8包括第十三电阻R18、第一升压变压器T1、第一稳压二极管D104、第二稳压二极管D105,输出电极9包括第一电极OUT1和第二电极OUT2,第一晶体管Q2、第二晶体管Q3和第三晶体管Q1是NPN型的,升压变压器8是第一升压变压器T1,第一升压变压器T1的初级线圈的匝数为60,中心抽头,第一升压变压器T1的次级线圈的匝数为2200,第一稳压二极管D104和第二稳压二极管D105的额定稳定电压为200伏,第一DA转换器U3的Vcc端与第二DA转换器U4的Vcc端连接后与+5伏端连接,第一DA转换器U3的接地端与第二DA转换器U4的接地端连接后与地线连接,第一DA转换器U3的D10端、D11端、D12端、D13端、D14端、D15端、D16端、D17端、第二DA转换器U4的D10端、D11端、D12端、D13端、D14端、D15端、D16端、D17端连接在一起,第一DA转换器U3的WR1端、第一DA转换器U3的WR2端、第二DA转换器U4的WR1端、第二DA转换器U4的WR2端连接在一起,第一DA转换器U3的CS端与第一DA转换器U3的Xfer端连接在一起,第二DA转换器U4的CS端与第二DA转换器U4的Xfer端连接在一起,第一DA转换器U3的ILE端与+5伏端连接,第一DA转换器U3的Iout端与地线连接,第一DA转换器U3的Vref端与第二DA转换器U4的Rfb端连接,第二DA转换器U4的Vref端与第二DA转换器U4的ILE端连接后与+5伏端连接,第二DA转换器U4的Iout2端与地线连接,第一运算放大器U5A的正电源端、第二运算放大器U6A的正电源端与+9伏端连接,第一运算放大器U5A的负电源端、第二运算放大器U6A的负电源端与-5伏端连接,第一电容C5跨接在-5伏端和地线之间,第一运算放大器U5A的正输入端和负输入端分别与第一DA转换器U3的Iout1端和Iout2端连接,第二运算放大器U6A的正输入端和负输入端分别与第二DA转换器U4的Iout1端和Iout2端连接,第一运算放大器U5A的输出端分别与第一DA转换器U3的Rbf端和第三运算放大器U5B的正输入端连接,第二运算放大器U6A的输出端与第二DA转换器U4的Rfb端连接,第一电位器POT1的两端跨接在第三运算放大器U5B的输出端和地线之间,第三运算放大器U5B的负输入端与第一电位器POT1的滑臂连接,第三运算放大器U5B的的输出端与第三晶体管Q1的基极连接,第三电阻R117、第二电容C6和第三电容C7并联后跨接在第三晶体管Q1的发射极和地线之间,第三晶体管Q1的集电极与+9伏端连接,第三晶体管Q1的发射极与第一升压变压器T1的中心抽头连接,第一非门U8A的输入端和输出端分别与第二非门U8B的输入端和输出端连接,第一非门U8A的输出端通过第一电阻R15与第一晶体管Q2的基极连接,第一晶体管Q2的集电极与第一升压变压器T1初级线圈的一端连接,第一晶体管Q2的发射极与地线连接,第三非门U8C的输入端和输出端分别与第四非门U8D的输入端和输出端连接,第三非门U8C的输出端通过第二电阻R16与第二晶体管Q3的基极连接,第二晶体管Q3的集电极与第一升压变压器T1初级线圈的另一端连接,第二晶体管Q3的发射极与地线连接,第一二极管D101的阴极和阳极分别与第一晶体管Q2的集电极和地线连接,第二二极管D102的阴极和阳极分别与第二晶体管Q3的集电极和地线连接,第一比较器U7A的正电源端和负电源端分别与+5伏端和-5伏端连接,第二比较器U7B的正输入端与地线连接,第六电阻R24跨接在第二比较器U7B的输出端和负输入端之间,第五电阻R25的一端与第二比较器U7B的负输入端连接,第三二极管D103的阴极和阳极分别与第五电阻R25的另一端和第一比较器U7A的输出端连接,第五电容C8和第四电阻R26并联后跨接在第三二极管D103的阴极和地线之间,第七电阻R23跨接在第一比较器U7A的负输入端和地线之间,第四比较器U7D的负输入端与第四比较器U7D的输出端连接,第八电阻R21跨接在第四比较器U7D的负输入端和第一比较器U7A的负输入端之间,第三比较器U7C的负输入端与第三比较器U7C的输出端连接,第九电阻R22跨接在第三比较器U7C的负输入端和第一比较器U7A的正输入端之间,第一稳压二极管D104和第二稳压二极管D105背对背串联后跨接在第一升压变压器T1次级线圈的两端,第十三电阻R18跨接在第一升压变压器T1次级线圈的一端和第一电极OUT1之间,第一升压变压器T1次级线圈的另一端与第二电极OUT2连接,第十二电阻R19跨接在第一升压变压器T1次级线圈与第十三电阻R18连接的一端和第四比较器U7D的正输入端之间,第十一电阻R20跨接第三比较器U7C的正输入端和第一电极OUT1之间,第一DA转换器U3的D10端与A点连接,第一DA转换器U3的CS端与B点连接,第一DA转换器U3的WR1端与C点连接,第二DA转换器U3的CS端与D点连接,第二比较器U7B的输出端与E点连接,第一非门U8A的输入端与F点连接,第三非门U8C的输入端与G点连接。A physical therapy instrument for treating diabetic peripheral neuropathy, comprising a
简要工作原理:Brief working principle:
1、电源开关S8:接通市电220V/50HZ交流电,使仪器进入开机待命状态。1. Power switch S8: Connect the mains 220V/50HZ AC to make the instrument enter the standby state.
2、治疗模式选择S1:治疗模式选择采用轮回递增方式转换,每按一次键,模式转换一次,数码显示1,输出连续波,数码显示2,输出突发波,数码显示3,输出变幅波,数码显示4,输出综合波。2. Treatment mode selection S1: The treatment mode selection adopts reincarnation incremental mode conversion, each time the key is pressed, the mode is converted once,
3、治疗开始S6、治疗停止S7:按下治疗开始S6键,仪器开始工作,此时输出强度为零,已开始计时,一直到设定时间自动停止。按治疗停止S7键,仪器停止工作,进入开机待命状态。3. Treatment start S6, treatment stop S7: Press the treatment start S6 key, the instrument starts to work, at this time the output intensity is zero, the timing has started, until the set time automatically stops. Press the treatment stop S7 key, the instrument stops working and enters the standby state.
4、治疗强度增加S2、治疗强度减少键S3:在仪器开始工作后按下治疗强度增加S2,仪器输出强度逐渐增强,数码显示输出强度逐渐增强,按治疗强度减少键S3,仪器输出强度逐渐减小,数码显示输出强度逐渐减小。4. Treatment intensity increase S2, treatment intensity decrease key S3: After the instrument starts to work, press the treatment intensity increase S2, the output intensity of the instrument will gradually increase, and the digital display output intensity will gradually increase, press the treatment intensity decrease key S3, the instrument output intensity will gradually decrease Small, the digital display output intensity gradually decreases.
5、治疗时间增加S4、治疗时间减少S5:在治疗开始前设定好时间,按治疗时间增加S4,治疗时间延长,数码显示治疗时间增加,按治疗时间减少S5,治疗时间缩短,数码显示治疗时间减少。5. The treatment time is increased by S4, and the treatment time is decreased by S5: set the time before the treatment starts, increase the treatment time by S4, the treatment time will be extended, and the digital display will increase the treatment time, and the treatment time will be decreased by S5, the treatment time will be shortened, and the digital display will treat Time decreases.
6、除了电源开关S8以外,所有其余7个按键都与智能控制器2连接,按下每一个键会自动产生一个按键代码,智能控制器2会按照不同的代码作出相应的处理。6. Except for the power switch S8, all other 7 buttons are connected to the
与现有理疗仪技术相比较,本发明理疗仪具有以下优势:Compared with the existing physical therapy instrument technology, the physical therapy instrument of the present invention has the following advantages:
1、采用变幅波,不断变换的冲动信号,使电极下深浅各部位的神经都得到充分的兴奋,为神经再生提供了良好的动力环境。1. Using variable-amplitude waves and constantly changing impulse signals, the nerves in the deep and shallow parts under the electrodes are fully excited, providing a good dynamic environment for nerve regeneration.
2、采用双向波,输出电极无需区分正负极性,且正负波同时发生,相位差180°,振幅相同,在两极间得到两倍波幅相加的作用,扩大了作用面积,加强了理疗功效,同时可减小脉冲强度,避免了灼伤事件。2. Using two-way waves, the output electrodes do not need to distinguish between positive and negative polarities, and positive and negative waves occur at the same time, with a phase difference of 180° and the same amplitude, and the effect of adding twice the amplitude between the two poles is obtained, which expands the area of action and strengthens physical therapy Efficacy, while reducing the pulse intensity, avoiding burn events.
3、利用两个DA转换器控制脉冲输出,实现了波幅、频率和脉宽的连续性调节,克服了理疗过程中调节模式和强度时患者的不适感,并通过智能控制器实现了数字化显示和调节,提高了人机对话的智能化程度。3. Two DA converters are used to control the pulse output, which realizes the continuous adjustment of amplitude, frequency and pulse width, overcomes the patient's discomfort when adjusting the mode and intensity during physical therapy, and realizes digital display and Adjustment improves the intelligence of man-machine dialogue.
4、利用多种低频低压脉冲及配方式的电流脉冲组合治疗,可实现因人而异、循序渐进的目的,提高治疗的安全性。4. Using a variety of low-frequency and low-voltage pulses and current pulse combination therapy with matching methods can achieve the purpose of varying from person to person and step by step, and improve the safety of treatment.
5、神经冲动传入脑和垂体,引起脑内吗啡样多肽释放,可达到镇痛效果。5. Nerve impulses are transmitted to the brain and pituitary gland, causing the release of morphine-like polypeptides in the brain, which can achieve analgesic effect.
6、该理疗仪操作简便,外形上机壳尺寸、机壳材质散热空间大,延长了连续使用时间。6. The physiotherapy instrument is easy to operate, and the size of the casing and the material of the casing have a large heat dissipation space, which prolongs the continuous use time.
附图说明 Description of drawings
图1是本发明理疗仪面板示意图,其中,LCD1是治疗模式选择显示屏,LCD2是治疗强度显示屏,LCD3是治疗时间显示屏,S1是选择治疗设定键,S2是治疗强度增加键,S3是治疗强度减小键,S4是治疗时间增加键,S5是治疗时间减小键,S6是治疗开始键,S7是治疗停止键,S8是电源开关。Fig. 1 is the schematic diagram of the panel of the physical therapy instrument of the present invention, wherein, LCD1 is the treatment mode selection display screen, LCD2 is the treatment intensity display screen, LCD3 is the treatment time display screen, S1 is the selection treatment setting key, S2 is the treatment intensity increase key, S3 It is the key to reduce the treatment intensity, S4 is the key to increase the treatment time, S5 is the key to decrease the treatment time, S6 is the key to start the treatment, S7 is the key to stop the treatment, and S8 is the power switch.
图2是本发明理疗仪的原理框图,其中,1是电源,2是智能控制器,3是按键接口,4是数码显示器,5是极性控制电路,6是脉冲控制电路,7是自检电路,8是升压变压器,和9是输出电极。Fig. 2 is the functional block diagram of the physical therapy apparatus of the present invention, wherein, 1 is power supply, 2 is intelligent controller, 3 is button interface, 4 is digital display, 5 is polarity control circuit, 6 is pulse control circuit, 7 is self-inspection circuit, 8 is the step-up transformer, and 9 is the output electrode.
图3是本发明理疗仪核心部分的电路图。Fig. 3 is a circuit diagram of the core part of the physical therapy instrument of the present invention.
具体实施方式 Detailed ways
现结合附图和实施例,对本发明作进一步的说明。Now in conjunction with the accompanying drawings and embodiments, the present invention will be further described.
实施例1Example 1
本实施例具有与发明内容所述理疗仪完全相同的电路,以下仅罗列关键的技术数据:This embodiment has the same circuit as the physical therapy instrument described in the summary of the invention, and only the key technical data are listed below:
第一DA转换器U3的型号是DAC0823;The model of the first DA converter U3 is DAC0823;
第二DA转换器U4的型号是DAC0823;The model of the second DA converter U4 is DAC0823;
第一运算放大器U5A、第三运算放大器U5B的型号是LM358;The models of the first operational amplifier U5A and the third operational amplifier U5B are LM358;
第二运算放大器U6A的型号是LM358;The model of the second operational amplifier U6A is LM358;
第一非门U8A、第二非门U8B、第三非门U8D和第四非门U8C的型号是74LS04;The models of the first NOT gate U8A, the second NOT gate U8B, the third NOT gate U8D and the fourth NOT gate U8C are 74LS04;
第一比较器U7A、第二比较器U7B和第三比较器U7C和第四比较器U7D的型号是CA084;The models of the first comparator U7A, the second comparator U7B, the third comparator U7C and the fourth comparator U7D are CA084;
第一晶体管Q2、第二晶体管Q3和第三晶体管Q1的型号是TIP41C;The models of the first transistor Q2, the second transistor Q3 and the third transistor Q1 are TIP41C;
第一二极管D101、第二二极管D102和第三二极管D103的型号是1N4148;The models of the first diode D101, the second diode D102 and the third diode D103 are 1N4148;
第一稳压二极管D104和第二稳压二极管D105的额定稳定电压为200伏。The rated stable voltage of the first zener diode D104 and the second zener diode D105 is 200 volts.
本实施例的控制方法如下:The control method of the present embodiment is as follows:
1、启动控制器电源:采用AC220V,50Hz±1Hz电源,系统初始化并进行端口设置;1. Start the controller power supply: AC220V, 50Hz±1Hz power supply, system initialization and port settings;
2、开机:按下电源开关键S8即开机,显示绿灯,再次按下即关机,绿灯关闭;2. Start up: press the power switch S8 to start up, display a green light, press it again to shut down, and the green light is off;
3、治疗模式的设定:按下选择治疗设定键S1即进入输出波形组合模式设置,选择①模式1(连续波),脉冲频率为2Hz,脉冲宽度200us,选择②模式2(突发波),脉冲频率2Hz,脉冲宽度200us,选择③模式3(变幅波),脉冲频率2Hz与100Hz交替,每种频率持续1分钟,间隔期3秒,脉冲宽度:200us,选择④模式4(综合波),模式1、模式2、模式3波组合循环,上述频率允许误差均为±5%,波宽允许误差均为±20%;3. Setting of treatment mode: Press the selection treatment setting key S1 to enter the output waveform combination mode setting, select ① mode 1 (continuous wave), pulse frequency is 2Hz, pulse width 200us, select ② mode 2 (burst wave ), pulse frequency 2Hz, pulse width 200us, select ③ mode 3 (variable amplitude wave), pulse frequency 2Hz and 100Hz alternately, each frequency lasts 1 minute,
4、工作时间的设定:按治疗时间增加键S4、治疗时间减小键S5可调整治疗时间长短,设定值不大于4小时;4. Setting of working time: press the treatment time increase key S4 and treatment time decrease key S5 to adjust the treatment time length, and the set value is not more than 4 hours;
5、开始/终止治疗:清洁刺激部位皮肤,将电极片放置于神经肌肉伤患处,按下治疗开始键S6即开始治疗,LCD3显示倒计时时间,时间数码管小数点闪亮,倒计时为0时智能控制器停止输出,过程中按治疗停止键S7,可随时终止治疗;5. Start/stop treatment: clean the skin of the stimulated part, place the electrode sheet on the neuromuscular injury, press the treatment start button S6 to start the treatment, LCD3 displays the countdown time, the decimal point of the time digital tube is flashing, and the countdown is 0 when intelligent control The output of the device stops, and the treatment can be terminated at any time by pressing the treatment stop key S7 during the process;
6、治疗强度的设定:治疗过程中,按治疗强度增加键S2、治疗强度减小键S3,可连续调整输出功率,设定值不大于40。6. Setting of treatment intensity: During the treatment process, press the treatment intensity increase key S2 and the treatment intensity decrease key S3 to continuously adjust the output power, and the set value is not greater than 40.
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