CN101411730B - Use of oak extract in preparing medicament for treating epidermis injury of person - Google Patents
Use of oak extract in preparing medicament for treating epidermis injury of person Download PDFInfo
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- CN101411730B CN101411730B CN2007101561376A CN200710156137A CN101411730B CN 101411730 B CN101411730 B CN 101411730B CN 2007101561376 A CN2007101561376 A CN 2007101561376A CN 200710156137 A CN200710156137 A CN 200710156137A CN 101411730 B CN101411730 B CN 101411730B
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides application of a Quercus extracting solution in preparing a medicine for treating human epidermal injury (comprising burn or scald, trauma, bite of animals and insects, infected wound, pimple and the like); the Quercus extracting solution is extracted and obtained through the following method: Quercus branches are burned; discharged gas is condensed and reclaimed to obtain a coarse extracting solution; the coarse extracting solution is kept stand in a closed vessel, is fermented for 3 to 4 months and is delaminated; upper-layer liquid and lower-layer liquid are discarded; middle-layer liquid is taken out to obtain stock liquid; the stock liquid is distilled; and a distillate with cut fractions of between 102 and 104 DEG C is taken out, is adsorbed for 3 to 6 hours through active carbon and is filtered to obtain the Quercus extracting solution. The Quercus extracting solution has special efficacies of treating burn and scald of people, bite of animals and insects, trauma and pimple and lays a foundation for the screening of new medicines.
Description
(1) technical field
The present invention relates to the application of oak extract in the medicine of preparation treatment epidermis injury of person (comprising burn, scald, wound, animal insect bite, comedo, infected wound etc.).
(2) background technology
Querci Mongolicae claims robur, Oak Tree again, and the Fagaceae oak belongs to the general designation of (Quercus) seeds, is a kind of economic trees that make the main feedstuff of Antherea pernyi Guerin-Meneville with its leaf.Be fallen leaves or aiphyllium, minority is a shrub.Leaf margin has sawtooth, rare full edge.The male flower catkin is sagging, and the female flower list is born in the involucre.Nut Dan Sheng, the peel inwall does not have hair, and obsolete ovule is positioned at side outside the seed base portion.
Querci Mongolicae has 300 kinds approximately, and all there is distribution in Asia, Europe, Africa, America, and there is abundant Querci Mongolicae resource in countries such as China, the former Soviet Union, the U.S., India.In kind surplus the state-owned Querci Mongolicae 60, toothed oak woods area has more than 100,000,000 mu approximately.With provinces and regions such as Heilungkiang, Liaoning, Jilin, Inner Mongol, Shandong, Henan, Guizhou, Guangxi, Anhui, Shaanxi, Sichuan is many.The high mountain of vertical distribution from the level land to height above sea level 3000m all can be grown, and the high mountain oak can be grown in height above sea level 4600m place at the middle part, Sichuan.
Quercus liaotungensis (Q.liaotungensis): the leaf sclerosis early should not be raised the silkworm in late fall.Mainly be distributed in provinces such as Heilungkiang, Jilin, Liaoning, Hebei, Henan, Shandong, Sichuan, Gansu.
Quercus acutissima (Q.acutissima): seeds are good, happiness light, happiness high temperature, should be subject to freeze injury in moist climate and the fertile local growth of soil property, are suitable for supporting the autumn silkworm.All there is distribution in provinces such as Shandong, Henan, Hebei, Liaoning, Gansu, Jiangsu, Jiangxi.
Quercus mongolica (Q.mongolica): happiness light, cold resistant, arid, barren, the easy infection powdery mildew suits to support the spring young silkworm.Heilungkiang, Jilin, Liaoning San Sheng are the major production areas.
Cork oak (Q.variabilis): happiness light, happiness temperature, drought-resistant, cold resistant not.Be distributed in provinces such as Shandong, Hunan, Hubei, Jiangxi, Yunnan, Zhejiang.
Daimyo oak (Q.dentate): should be grown in bright and clear, the place that weather is warm.More drought-resistant, but the food value of leaf is poor.Mainly be distributed in provinces such as Liaoning, Jilin, Heilungkiang, Shandong, Shaanxi, Sichuan, Hubei, Yunnan.
Folium Querci Mongolicae contains compositions such as moisture, protein, carbohydrate, fat, ash, cellulose, Antherea pernyi Guerin-Meneville happiness food.
Querci Mongolicae except that its leaf with raising Antherea pernyi Guerin-Meneville, the firm anti-corrosion property of timber is strong, architectural extensive use is arranged, but processing and fabricating furniture is also fired Linesless charcoal.Fructus Querci acutissimae is starch-containing more, can be used to make rubber wine, ethanol, starch, rubber wet goods.Also can make feedstuff.The tannin that extracts from Querci Mongolicae bark, blade, acorn-cup, Fructus Querci acutissimae is a necessary material in leather industry, printing and dyeing industry and the fishery.The cortex of cork is thicker makes industrial vegetable cork.Xylosmae japonici also can be cultivated multiple eating bacterium such as Auricularia, Lentinus Edodes and armillaria mellea.
Yet there are no the report that oak extract is applied to treat people's burn or scald, wound, animal insect bite, infected wound, comedo.
(3) summary of the invention
The present invention promptly is for the application of oak extract in the medicine of preparation treatment epidermis injury of person (comprising burn or scald, wound, animal insect bite, infected wound, comedo etc.) is provided.
The technical solution used in the present invention is:
The application of oak extract in the medicine of preparation treatment epidermis injury of person; Described oak extract is extracted by following method and obtains: burning Querci Mongolicae (Quercus) branch, and the expellant gas condensation is reclaimed, and gets crude extract; Crude extract standing for fermentation 3～4 months in closed container, layering discards the upper and lower liquid, gets middle level liquid, stock solution; Stock solution is got the distillate of 102～104 ℃ of fractions through distillation, and distillate filters again through activated carbon adsorption 3～6 hours, promptly gets described oak extract.
Described Querci Mongolicae is one of following: 1. Quercus liaotungensis, 2. Quercus acutissima, 3. Quercus mongolica, 4. cork oak, 5. Fructus Ananadis comosi oak.
Described epidermis injury of person comprises: people's epidermis burn or scald, people's epidermis wound are damaged or hemorrhage, people's epidermis is by animal (as cat, Canis familiaris L. etc.) or insect bite, disease such as people's epidermis that comedo and other reasons cause is struvite, infectious, suppurative.
Oak extract of the present invention can directly be smeared or after distilled water or medical alcohol dilution (2 times), be applied in the position of human epidermal damage, also can add other pharmaceutic adjuvants, makes the treatment that unguentum, liniment, spray are used for the human epidermal damage location.
Beneficial effect of the present invention is mainly reflected in: oak extract of the present invention to the treatment epidermis injury of person especially burn, scald, bite, organic or functional wound, comedo have special effect, for new medicament screen provides the foundation.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1: the oak extract preparation
(1) burning Querci Mongolicae Quercus mongolica (Q.mongolica) branch (comprising trunk and leaves) is sealed up a door, and expellant gas reclaims with cooling water condensation, obtains crude extract;
(2) crude extract is sub-packed in the closed container after collecting immediately, and standing for fermentation 4 months is divided into three layers naturally behind the fermenting-ripening, discard the upper and lower liquid, gets middle level liquid, gets stock solution;
(3) stock solution is got the distillate of 102～104 ℃ of fractions through distillation, and distillate is again through activated carbon adsorption 4 hours, filter paper filtering 3 times, and filtrate is described oak extract, and (water white transparency is deposited long afterwards to light yellow to yellowish-brown, but is not affected the treatment; The smoked smell of burning is arranged; Extracting solution include nitrogenous bases such as aminoacid, organic acid, alcohols, phenols, ketone and amine, methylamine class, dimethyl amine, pyridines, or the like the multiple composition of component).
Embodiment 2: the oak extract bactericidal assay
1. trial drug: embodiment 1 gained oak extract.
2. tried microorganism: staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC15442.
3. action time: 5min.
4. bactericidal assay method: suspension method in vitro adds bacterium amount (tried bacterium, oak extract mixes the back) 1 * 10
7-5 * 10
7Cfu/ml.Test repeats 3 times.
5. bactericidal effect: embodiment 1 gained oak extract stock solution and 2 times of diluents (oak extract and water volume ratio 1: 1) sterilizing rate are all more than 99.999%.
Embodiment 3: the electric welding treatment of scald is observed
1. medical record overview: Guo patient so-and-so, the electric welder, left hand ancon electric welding wound 80mm * 28mm (the widest part) wound 1 place requires to execute to control.
2. handle; The direct sprayed coating of embodiment 1 gained oak extract is scalded local, and every day 2 times, redness disappeared, do not have suppuration, do not have and infect next day; Healing after 5 days.Patient's readme, electric welding are in the past scalded and are used " scald medicine ", and wound can be red and swollen, suppurates, and can not heal for a long time.Claim this medicine (oak extract) curative effect mystery.
Embodiment 4: the frying oil treatment of scald is observed
1. medical record overview: patient Lee so-and-so, the Oryza glutinosa Semen Sesami is rolled into a ball fried worker, right-hand man and face are spattered flower everywhere by oil cauldron and scald, right hand especially severe, the red and swollen foaming, blister joins together and spreads all over the whole hands back of the body; Forehead is scalded, and gets blister 4, the about 20mm of diameter, and volume and the vesicle diameter 5mm of face portion, 3mm do not wait, and be individual surplus counting 10.
2. handle: embodiment 1 gained oak extract is directly smeared after scalding 5 minutes and is scalded the part, sprays later every day 4 times.After to the 3rd day blister being needled, smear again; To the 5th day, wound began convergence; Wound healing began the dead bark that comes off in the 8th day.So far, scalding healing is local with healthy skin is consistent all around, and any scald vestige is stayed in nothing left.
Embodiment 5: the boiled water treatment of scald is observed
1. medical record overview: suffer from male Bao, 5 years old, front, face, thigh were scalded by the boiled water that just burnt the same day, and the traumatic part redness is got blister.
2. handle: get embodiment 1 gained oak extract 250ml, directly smear with the cotton balls soaked extracting solution and scald the position, smear repeatedly, lasting 1 hour surplus; Morning next day, local redness alleviated, and blister is needled this extracting solution of back spray, 4-5 spraying medication every day; Wound healing after 15 days is scalded local Rhizoma Euonymus and is come off, and does not see so far and leaves over any scald vestige.
Embodiment 6: face's traumatism treatment is observed
1. medical record overview: suffer from male Wu so-and-so, face's many places scratch, the degree of depth mostly is 1mm; The scratch of cheekbone portion reaches 2mm, long 35mm 1 place deeply.
2. handle: get embodiment 1 gained oak extract, leach the part that paints a wound with cotton balls; Rise next day, and with method paint a wound with hot towel hot compress every day again; After 3 days, scab and begin to come off in the wound part; The area that comes off after 5 days reaches 70% approximately; The 9th day, all healings.Do not have and leave over scuff mark.
Embodiment 7: nose, face are observed by the lyssodexis treatment
1. medical record overview: suffer from woman China so-and-so, 5 years old, nose, the right side wing of nose, the nearly endocanthion of right side bridge of the nose place were all hemorrhage by tame lyssodexis, bit to hinder local dog immediately at that time that outpatient service requires in accordance with regulations and standard inoculation rabies vaccine and rabies antiserum; The anxious immediately Hangzhou cosmetic surgery hospital row nose that send is snapped the shaping of skin disappearance; Cosmetic surgeons treat wound " healing voluntarily " institute's second phase plastic operation afterwards because of hindered refusal punishment and plastic operation and doctor's advice by dog class animal after interrogating medical history.
2. handle: the back 3 hours patients that see and treat patients that bite, confirming that the patient has implemented to prevent rabies measure and relevant hospital all to refuse under the punishment situation, get embodiment 1 gained oak extract, leach the part that paints a wound, every day 4 times with cotton balls; Continuous application 12 days.The result: play the wound convergence next day, does not infect the part; After continuation was used, the local skin incrustation formed, and to hindering position, back 8 days canthus decrustation, hinders back 12 days nose position decrustation, and the former disappearance of being bitten is organized and seen that reparation is complete; The tissue of repairing is fresh and tender, red.At present, only can see that there is 0.2 * 2.0cm at the nose position, the right side endocanthion respectively has up and down outside the skin vestige of the slight protuberance of the about 0.2cm of 0.4 * 0.5cm and diameter, and is surplus not different from.Estimate to move back automatically through 1 first quarter moon to 3 month local red more to the greatest extent consistent with surrounding tissue skin; 6 months to 1 year half, the vestige of protuberance will be all smooth automatically also, and will be consistent with surrounding skin.(hindered back 30 days) existing effect as seen at present, the therapeutic effect that this extracting solution is used far is superior to dermatoplastic treatment, is approved that by personnel in of the same trade curative effect is peculiar.
Embodiment 8: mosquito bite is hindered treatment and is observed
1, medical record overview: patient Lu so-and-so, so-and-so waits 5 people Wu, is bitten repeatedly by mosquito, feels immediately after being snapped that local pain feels bad.
2, punishment: immediately at partial smearing embodiment 1 gained oak extract, pain is upright ends when biting, and the overworked and pimple shape protuberance of pain no longer occurs.Overworked and the local pimple sample protuberance of pain is all arranged when not using.Use in 3-5 minute after being snapped, effect is splendid; Use still effective in 10 minutes.Totally think: this extracting solution treatment mosquito is bitten, and more early uses curative effect good more!
Embodiment 9: the comedo treatment is observed
1, medical record overview: suffer from women Lu so-and-so etc. example surplus 10, two cheeks and forehead comedo piece number and distributing do not wait, the pox head suppurate but not ulceration or suppurate all have.
2, punishment: after the patient cleans face, take embodiment 1 gained oak extract, earlier comedo and all around the position smear sterilization; Then, use the sterile needle point to puncture the comedo head, and extrude purulent secretion gently, take oak extract (under eye, nose are screened) sprayed coating again; Also can not puncture epidermis, directly the sprayed coating extracting solution.Promptly see comedo convergence (mouth) after result: 2-3 days, recovery from illness in 5-7 days.Simultaneously, adopt embodiment 1 gained oak extract and vanishing cream, Margarita powder to be modulated into cream, every day 1 time, all fully recovers about 15 days in the hot water back whole face of the coating portion that washes one's face, and does not find untoward reaction such as any skin allergy.
Oak extract test/clinical treatment observation of the present invention is overall conclusion as a result:
1. remarkable to the killing action of staphylococcus aureus, bacillus pyocyaneus, sterilizing rate is all more than 99.999%.
2. to the treatment of various all kinds of scalds such as oils, boiled water, electric welding, burn, specially good effect is arranged; And do not have and leave over cicatrix.
To skin injury, by animal bite, the external curing effect of various skin trauma breakages such as sting injures suppuration is remarkable.
4. remarkable to the external curing effect of comedo.
5. sterilization, antiinflammatory, removing the necrotic tissue, granulation promoting arranged, promote the production of body fluid, repair, regenerate, keep fit, the effect of infection.
Be fit to be applied to people's body surface damage that various all kinds of reasons cause, as skin injury, functional wounds such as burn and scald, wound, animal insect bite, comedos, and the treatment of struvite, infectious, suppurative human body surface diseases.
Claims (7)
1. the application of oak extract in the medicine of preparation treatment epidermis injury of person; Described oak extract is extracted by following method and obtains: burning Querci Mongolicae (Quercus) branch, and the expellant gas condensation is reclaimed, and gets crude extract; Crude extract standing for fermentation 3～4 months in closed container, layering discards the upper and lower liquid, gets middle level liquid, stock solution; Stock solution is got the distillate of 102～104 ℃ of fractions through distillation, and distillate filters again through activated carbon adsorption 3～6 hours, and filtrate is described oak extract.
2. application as claimed in claim 1 is characterized in that described Querci Mongolicae is one of following: 1. Quercus liaotungensis, 2. Quercus acutissima, 3. Quercus mongolica, 4. cork oak, 5. Fructus Ananadis comosi oak.
3. application as claimed in claim 1 is characterized in that the application of oak extract in preparation treatment people epidermis burn or scald medicament.
4. application as claimed in claim 1 is characterized in that the application of oak extract in preparing the damaged or hemorrhage medicine of treatment people epidermis wound.
5. application as claimed in claim 1 is characterized in that oak extract is preparing treatment people epidermis by the application in the medicine of animal or insect bite.
6. application as claimed in claim 1 is characterized in that the application of oak extract in the medicine of preparation treatment people comedo.
7. application as claimed in claim 1 is characterized in that the application in the medicine of oak extract or purulent disease struvite or infectious at people's epidermis that preparation treatment staphylococcus aureus or Pseudomonas aeruginosa cause.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101561376A CN101411730B (en) | 2007-10-19 | 2007-10-19 | Use of oak extract in preparing medicament for treating epidermis injury of person |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101561376A CN101411730B (en) | 2007-10-19 | 2007-10-19 | Use of oak extract in preparing medicament for treating epidermis injury of person |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101411730A CN101411730A (en) | 2009-04-22 |
| CN101411730B true CN101411730B (en) | 2011-01-26 |
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| CN2007101561376A Expired - Fee Related CN101411730B (en) | 2007-10-19 | 2007-10-19 | Use of oak extract in preparing medicament for treating epidermis injury of person |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102038716B (en) * | 2009-10-23 | 2012-08-22 | 秦云飞 | Traditional Chinese medicine extraction method and special device |
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| CN101411730A (en) | 2009-04-22 |
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Effective date of registration: 20091030 Address after: Hangzhou City, Zhejiang Province, Binjiang District west street flourishing garden 1 Building 2 unit 601 room post encoding: 310051 Applicant after: Lu Miaogui Co-applicant after: Wu Jiangping Address before: Hangzhou City, Zhejiang Province, Binjiang District west street flourishing garden 1 Building 2 unit 601 room post encoding: 310051 Applicant before: Lu Miaogui |
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