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CN101411671B - 新型药用冻干瓶塞 - Google Patents

新型药用冻干瓶塞 Download PDF

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Publication number
CN101411671B
CN101411671B CN 200810197286 CN200810197286A CN101411671B CN 101411671 B CN101411671 B CN 101411671B CN 200810197286 CN200810197286 CN 200810197286 CN 200810197286 A CN200810197286 A CN 200810197286A CN 101411671 B CN101411671 B CN 101411671B
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bottle stopper
freeze
bottle
packaging
dried
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CN101411671A (zh
Inventor
石雄安
夏汉桥
丁安华
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Hengtian Pharmaceutical Package Co ltd
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Hengtian Pharmaceutical Package Co ltd
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Abstract

本发明涉及一种瓶盖，具体地说是一种新型药用冻干瓶塞。它包括瓶塞，瓶塞的中心开有圆形孔，其特征是：所述的瓶塞的外围均匀开有四个圆形通气凹槽，瓶塞的外壁上设有凸齿，瓶塞的颈部设有3°导向角。本发明具有结构简单、使用方便的优点，它能够使包装瓶具有很好的气密性，在冻干粉针剂生产和包装过程中具有冻干效果好、上机效率高的优点，有利于药品的快速真空无菌包装，提高产品质量和效率。

Description

新型药用冻干瓶塞
技术领域
本发明涉及一种瓶盖，具体地说是一种新型药用冻干瓶塞。
背景技术
现有的针剂和粉剂药品一般采用瓶装，尤其是冻干粉针剂一般根据国家医药产品标准都采用瓶装，并采用橡皮瓶盖密封保存。冻干粉针剂的生产一般是将含有药物有效成分的药液冻干后进行真空无菌包装，其生产过程一般很长。例如某一产品的生产过程如下：首先降温2小时，温度降至-40℃，维持此温度约6小时；开始逐步升温至25℃，此过程中要求真空状态，保持真空30-35Pa左右，需耗时约48小时；结束冻干，压盖，包装得成品。在冻干过程中既要将药瓶盖上，保持无菌，又要使瓶盖不能盖的太严密，以免药液中的水分不能够迅速蒸发，影响冻干的时间。这就要求瓶盖既要气密性好，又要满足冻干效果好、上机效率高，有利于药品的真空无菌包装。现有的药用瓶盖结构比较简单，如图1所示一般都是普通的一次成型结构，它具有气密性好的优点，但是它不能够满足冻干粉针剂生产所要求的冻干效果好和真空快速无菌包装的条件。因此发明一种新型的药用瓶盖，以满足冻干粉针剂生产的要求非常有益。
发明内容
本发明所要解决的技术问题是：针对现有药瓶盖存在的缺陷，提供一种新型药用冻干瓶塞，它在冻干粉针剂生产和包装过程中，使包装瓶具有气密性好和冻干效果好的优点，有利于药品的真空无菌包装。
本发明的技术方案是这样实现的：它包括瓶塞，瓶塞的中心开有圆形孔，其特征是：所述的瓶塞的颈部外围均匀开有四个圆形通气凹槽，瓶塞的外壁上设有凸齿，瓶塞的颈部设有3°导向角。这样可以提高瓶塞的加塞效率。
本发明具有结构简单、使用方便的优点，它能够使包装瓶具有很好的气密性，在冻干粉针剂生产和包装过程中具有冻干效果好、上机效率高的优点，有利于药品的快速真空无菌包装，提高产品质量和效率。
附图说明
图1为现有技术的结构示意图
图2为本发明的结构示意图
图3为图2的中心剖视图
图4为图2的俯视图
具体实施方式
以下结合附图对本发明作进一步描述：
如图2、图3所示，本发明包括瓶盖1和瓶塞2，瓶塞2的外围均匀开有四个圆形通气凹槽3。如图4所示，瓶塞的中心开有圆形孔4；所述的瓶塞的外壁上设有凸齿5，瓶塞的颈部设有3°导向角。
在冻干粉针剂生产过程中，先将瓶盖盖在药瓶上至凸齿5处，此时药瓶处于半密封状态，水蒸气可以从四个圆形通气凹槽3蒸发掉，这样既保证了药液的卫生，又能够使水蒸气快速蒸发，缩短冻干的时间。冻干完后，直接将瓶盖轻轻压紧即可完全密封，实现快速真空无菌包装，提高产品质量和效率。

Claims (1)

1.一种新型药用冻干瓶塞，它包括瓶塞，瓶塞的中心开有圆形孔，其特征是：所述的瓶塞的颈部外围均匀开有四个圆形通气凹槽，瓶塞的外壁上设有凸齿，瓶塞的颈部设有3°导向角。
CN 200810197286 2008-10-16 2008-10-16 新型药用冻干瓶塞 Expired - Fee Related CN101411671B (zh)

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CN 200810197286 CN101411671B (zh) 2008-10-16 2008-10-16 新型药用冻干瓶塞

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Application Number Priority Date Filing Date Title
CN 200810197286 CN101411671B (zh) 2008-10-16 2008-10-16 新型药用冻干瓶塞

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CN101411671A CN101411671A (zh) 2009-04-22
CN101411671B true CN101411671B (zh) 2013-08-21

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105197855A (zh) * 2015-08-18 2015-12-30 大连双瑞科技有限公司 一种卡式瓶冻干装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3881626A (en) * 1972-11-20 1975-05-06 Warner Lambert Co Container closure for lyophilized products
EP0322548A1 (de) * 1987-12-24 1989-07-05 Helvoet Pharma N.V. Gefriertrocknungs-Stopfen
CA2178496A1 (en) * 1994-08-19 1996-02-29 C. Bradford Jones Vented vial for freeze-drying and method of minimizing contamination of freeze-dried products
CA2214816A1 (en) * 1996-09-27 1998-03-27 Becton Dickinson France, S.A. Lyophilization closure assembly for a medicament container for use during a lyophilization process
CN201263791Y (zh) * 2008-09-27 2009-07-01 应城市恒天药业包装有限公司 新型药用冻干瓶塞

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3881626A (en) * 1972-11-20 1975-05-06 Warner Lambert Co Container closure for lyophilized products
EP0322548A1 (de) * 1987-12-24 1989-07-05 Helvoet Pharma N.V. Gefriertrocknungs-Stopfen
CA2178496A1 (en) * 1994-08-19 1996-02-29 C. Bradford Jones Vented vial for freeze-drying and method of minimizing contamination of freeze-dried products
CA2214816A1 (en) * 1996-09-27 1998-03-27 Becton Dickinson France, S.A. Lyophilization closure assembly for a medicament container for use during a lyophilization process
CN201263791Y (zh) * 2008-09-27 2009-07-01 应城市恒天药业包装有限公司 新型药用冻干瓶塞

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