CN101361772B - Oral medicine for treating traumatic injury and production method thereof - Google Patents
Oral medicine for treating traumatic injury and production method thereof Download PDFInfo
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- CN101361772B CN101361772B CN2008100737563A CN200810073756A CN101361772B CN 101361772 B CN101361772 B CN 101361772B CN 2008100737563 A CN2008100737563 A CN 2008100737563A CN 200810073756 A CN200810073756 A CN 200810073756A CN 101361772 B CN101361772 B CN 101361772B
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Abstract
The invention relates to an oral drug for traumatic injuries and a production method thereof (No.2 tablets for bone setting). The production method comprises the following steps: (1) various raw materials are selected according to mass portion as follows: 300 to 500 of angelica, 100 to 200 of ground beetle, 500 to 600 of membranaceous beautyleaf root, 100 to 200 of native copper and 500 to 600 of himalaya teasel; (2) 266 mass portions of the himalaya teasel is ground into fine powder (a sieve with a size of 5 and 80 meshes ) for a standby purpose; (3) the angelica, the ground beetle, the membranaceous beautyleaf root and the rest himalaya teasel that is not ground are added with water for decocting; the native copper is decocted individually; then two decoction liquids are combined and subjected to decompression-concentration for being prepared into a thick paste with a relative density of 1.35 to 1.40 (at 50 DEG C); (4) the standby fine powder of the himalaya teasel is added in the thick paste, evenly stirred, dried, ground, added with proper amount of alcohol (with a concentration of 70 percent to 80 percent) for pelletization, added with proper amount of accessories and then pressed into tablets. The drug for traumatic injuries has remarkable and stable treatment effects on various traumatic injuries, especially on fracture in early period, is convenient for taking, does not cause skin allergy or other untoward effects and has simple production technique, and finished products has stable quality and low price.
Description
Technical field
Patent of the present invention relates to a kind of linear Chinese medicine composition that is used for the treatment of traumatic injury, more particularly, relates to a kind of traumatic injury that is used for the treatment of, especially for treatment the fracture oral Chinese medicine and the production method thereof in mid-term.
Background technology
At present, in the treatment traumatic injury, on the treatment fracture pharmaceutical market in mid-term, the Chinese medicine medicine that is used for oral medication seldom.Particularly at the medicine of each of fracture treatment still less, majority all is to be used for external application, external application or outer the wiping in stage.Externally applied herbal medicine required one day 24 hours to apply the pressure affected part, brought inconvenience and misery to the patient.Externally applied plaster all can cause skin allergy, skin rubefaction is itched a lot of people, even makes the difficult whole night dormancy of patient, and often effect is good inadequately.Apply medicinal lotion or ointment outward and generally all be to use the medicated wine of high spirit infusion, requiring when controlling firmly rubs is beneficial to drug absorption to generating heat executing, the misery that causes when so not only making the patient tolerate owing to friction, and much the people can produce skin allergy, and treatment can't be proceeded.And in the western medical treatment method,, cause accumulation in vivo easily because used Western medicine all is a synthetic drug, particularly some hormone medicines can produce various sequela to human body.So a lot of people are unwilling to use, so people urgently wish to develop a kind of instant effect, can not cause skin allergy and can not cause the oral administration medicine for treating traumatic injury and the production method (boneseting No. 2) thereof of side effect.
Summary of the invention
The object of the present invention is to provide a kind of pure Chinese medicine, instant effect, can not cause skin allergy and can not cause the oral administration medicine for treating traumatic injury of side effect.A kind of oral administration medicine for treating traumatic injury and the production method (sheet bonesets No. 2) thereof that can recover to have promising result to the mid-term of fracturing, soft tissue injury particularly will be provided.
The inventor uses the traditional Chinese medical science, Chinese medicine rationale in order to achieve the above object, has carried out deep research and experiment aspect the medication of the side of choosing.Found that, utilization is classified as principal agent to work as, the pharmaceutical composition of forming in specific ratio with Eupolyphaga Seu Steleophaga, Radix calophylli membranacei, Pyritum, Radix Dipsaci etc. 4 flavor accessory drugss can reach invigorating the liver and kidney by oral, and the effect of reunion of fractured tendons and bones can be improved patient's clinical sign, symptom more effectively.Patient's growth of spur is good, functional rehabilitation is fast thereby make, thereby because this test result has been finished the present invention.
Technical scheme of the present invention is as follows:
1. an oral administration medicine for treating traumatic injury is characterized in that wherein the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 300-500 mass parts, Eupolyphaga Seu Steleophaga 100-200 mass parts, Radix calophylli membranacei 500-600 mass parts, Pyritum 100-200 mass parts, Radix Dipsaci 500-600 mass parts.
2. technical scheme 1 described oral administration medicine for treating traumatic injury is characterized in that wherein the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 400 mass parts, Eupolyphaga Seu Steleophaga 133 mass parts, Radix calophylli membranacei 533 mass parts, Pyritum 133 mass parts, Radix Dipsaci 533 mass parts.
3. the production method of an oral administration medicine for treating traumatic injury (sheet bonesets No. 2), it is characterized in that this method comprises following step: (1) is ready to Radix Angelicae Sinensis 300-500 mass parts, Eupolyphaga Seu Steleophaga 100-200 mass parts, Radix calophylli membranacei 500-600 mass parts, Pyritum 100-200 mass parts, Radix Dipsaci 500-600 mass parts as raw material; (2) it is standby Radix Dipsaci 266 mass parts to be ground into fine powder (No. five sieve, 80 orders); (3) above-mentioned Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix calophylli membranacei three flavors and the remaining Radix Dipsaci of not pulverizing are decocted with water together, Pyritum decocts separately, merges two decocting liquids, and it is evaporated to the thick paste that relative density is 1.35-1.40 (50 ℃); (4) above-mentioned standby Radix Dipsaci fine powder be added in the thick paste stir, dry, pulverize, granulate, tabletting then.
4. as technical scheme 3 described oral administration medicine for treating traumatic injury and production method (sheet bonesets No. 2) thereof, it is characterized in that wherein the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 400 mass parts, Eupolyphaga Seu Steleophaga 133 mass parts, Radix calophylli membranacei 533 mass parts, Pyritum 133 mass parts, Radix Dipsaci 533 mass parts.
5. as technical scheme 3 described oral administration medicine for treating traumatic injury and production method (sheet bonesets No. 2) thereof, it is characterized in that in the step (3) three kinds of medical materials being decocted operation carries out in two steps, promptly, above-mentioned Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix calophylli membranacei three flavors and remainder are not pulverized Radix Dipsaci to be decocted with water together, Pyritum decocts separately, merge two decocting liquids, it is evaporated to the thick paste that relative density is 1.35-1.40 (50 ℃); (4) raw material fine powder and thick paste stir, that is, the Radix Dipsaci fine powder is added to thick paste stirs, and are dried, and are ground into fine powder then, again pelletizing press sheet.
6. as technical scheme 3 or 5 described oral administration medicine for treating traumatic injury and production method (sheet bonesets No. 2) thereof, it is characterized in that before the pelletizing press sheet of step (4), is that 70-80 alcohol water blend mixes with fine powder and mixes and stirs with concentration earlier, carries out pelletizing press sheet again.
7. as technical scheme 3 described oral administration medicine for treating traumatic injury and production method (sheet bonesets No. 2) thereof, the operation that decocts with water that it is characterized in that step (3) is carried out in two steps, 1.5-2 hours for the first time, 1-1.5 hours for the second time, twice decocting liquid merged, then it is evaporated to thick paste.
Beneficial effect of the present invention is as follows:
(1), has remarkable and stable curative effect especially mid-term to fracturing to various traumatic injury treatments.
(2) can be oral, taking convenience.
(3) can not cause skin allergy and other untoward reaction.
(4) production technology is simple, and end product quality is stable.
(5) cheap.
The specific embodiment
Enumerate embodiment and clinical practice example below and further explain the present invention
1, this preparation recipe principle: Radix Angelicae Sinensis sweet in the mouth, suffering, warm in nature, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving.Be used for blood deficiency and yellow complexion, rheumatic arthralgia, traumatic injury; Radix Dipsaci bitter in the mouth, suffering, slightly warm in nature, invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered.Be used for soreness of the waist and knees, rheumatic arthralgia, injury from falling down; Radix calophylli membranacei mildly bitter flavor, property are put down, and wind-damp dispelling are arranged, strengthening bone and muscle, the effect of promoting blood circulation and stopping pain.Cure mainly rheumatic arthritis, lumbago and skelalgia, traumatic injury; The Eupolyphaga Seu Steleophaga salty in the mouth, cold in nature.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones gathers benefiting vital QI and blood altogether, reunion of fractured tendons and bones, the effect of nourishing the liver and kidney.
2, each medicine of this preparation is in the scope of application of pharmacopeia and Guangxi medical material standard: Radix Angelicae Sinensis 6-12g, Eupolyphaga Seu Steleophaga 3-9g, Radix calophylli membranacei 533g, Pyritum 3-9g, Radix Dipsaci 9-15g.According to Chinese medicine " seven emotions " relation, the medication of prescription monarch produces synergism, and one day consumption of this preparation is: Radix Angelicae Sinensis 6g, Eupolyphaga Seu Steleophaga 2g, Radix calophylli membranacei 533g, Pyritum 2g, Radix Dipsaci 8g.。Use from the single medicinal material to the compatibility, passed through my institute and put into practice for a long time and progressively sum up, thereby be defined as best component proportion, clinical practice reaches optimum efficiency.It is the principal mode of middle medical drugs that the compatibility of medicine is used, and medicine is made up by certain law, and determines certain component proportion, makes appropriate dosage forms, also is the higher form that compatibility of drugs is used.
Embodiment 1:
Take by weighing Radix Angelicae Sinensis 400g, Eupolyphaga Seu Steleophaga 133g, Radix calophylli membranacei 533g, Pyritum 133g, Radix Dipsaci 533g respectively.It is standby that Radix Dipsaci 266g is ground into fine powder (No. five sieve, 80 orders).Above-mentioned Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix calophylli membranacei three flavors and remainder are not pulverized Radix Dipsaci to be decocted with water twice together, 2 hours for the first time, 1.5 hours for the second time, merge decocting liquid twice, filter, Pyritum decocts twice separately, 2 hours for the first time, 1.5 hours for the second time, merge decocting liquid twice, filter, its whole decocting liquids are evaporated to the thick paste that relative density is 1.35-1.40 (50 ℃); Above-mentioned standby Radix Dipsaci fine powder is added in the thick paste stir, with 100 ℃ of dryings, then it is ground into fine powder, mix and stir granulation with concentration 75% ethanol, 80 ℃ of dryings, arrangement granule.Add appropriate amount of auxiliary materials, be pressed into tablet by every 0.3g, obtain 1045 in tablet altogether with tablet machine.For simplicity, the tablet that hereinafter embodiment 1 is made abbreviates No. 2 sheets of bonesetting as.
Embodiment 2:
Carry out according to step similarly to Example 1, institute's difference is that the consumption of each material composition is as follows: Radix Angelicae Sinensis 450g, Eupolyphaga Seu Steleophaga 150g, Radix calophylli membranacei 600g, Pyritum 100g, Radix Dipsaci 600g.Obtain 1100 in tablet when being pressed into tablet by every 0.3g at last altogether.Hereinafter will
The tablet that embodiment 2 makes abbreviates 2 of No. 2 sheets of bonesetting as.
Embodiment 3:
Carry out according to step similarly to Example 1, institute's difference is that the consumption of each material composition is as follows: Radix Angelicae Sinensis 300g, Eupolyphaga Seu Steleophaga 100g, Radix calophylli membranacei 600g, Pyritum 200g, Radix Dipsaci 550g.Obtain 980 in tablet when being pressed into tablet by every 0.3g at last altogether.Hereinafter the tablet that embodiment 3 is made abbreviates 3 of No. 2 sheets of bonesetting as.
Clinical practice example 1:
2,4,6 three lesiones of in-patient department of the inventor location city-level hospitals of traditional Chinese and western medicine (Yulin City of Guangxi Zhuang Autonomous orthopaedics hospital), to fracturing early stage No. 1 sheet of bonesetting that uses after 1-2 weeks, continue to use No. 2 sheets of bonesetting of the present invention that 100 example fracture patients in mid-term have been carried out hospitalization and clinical observation record.
In this group patient 100 examples, male's 65 examples, women's 35 examples are the age 20-55 years old adult patients.The course of disease is for hindering the back 1-2 months.
Patient's clinical symptoms sign is roughly as follows behind the fracture early treatment: case, fracture of shaft of femur is 30 examples, fracture of tibia and fibula is 30 examples, humeral shaft fracture 40 examples, affected part local swelling pain is eliminated substantially, and general soft tissue injury is repaired, and existing fibroid connects between fracture site, callus begins to occur, and fractures is stable day by day.
This is organized 100 routine patients and continues to take No. 2 sheets of bonesetting of the present invention, every day 3 times, and each 5, taking medicine after meal, the lighter took for 3-4 weeks continuously.Heavy person or took 1-2 months according to clinical symptoms.
Undertaken by People's Republic of China's pharmaceuticals industry standard " disease of tcm diagnosis criterion of therapeutical effect " when during treating, carrying out clinical observation.All itemized record are on record to symptom, sign, lab testing result, adverse effect etc.Observe to this course of treatment always and finish.
All observation case fracture initial stages are all made routine blood test, routine urinalysis, fecal occult blood, liver function, renal function, Electrocardioscopy and X line fluoroscopic examination.Treatment through the laggard phase of compromising to the marrow of treatment at fracture initial stage.
By the basis principle of my institute development and with reference to pharmacopeia, medical material, use standard, scope:
1. this preparation is the cipher prescription of my institute, is pure Chinese medicinal preparation.Be that my institute is used for the treatment of traumatic injury for over ten years, the common drug of fracturing mid-term.Consult interrelated data and do not see that the pharmaceutical preparation with the side of the same name is arranged, this preparation prescription is studied by clinical observation, has formed the prescription foundation that diagnosis and treatment with the dialectical differential diagnosis of diseases of the combination of Chinese and Western medicine adapt.According to dialectical differential diagnosis of diseases diagnosis, utilization non-operative treatment and operative treatment have benefiting vital QI and blood with this this preparation clinically, nourishing liver and kidney, and the effect of reunion of fractured tendons and bones has obtained satisfied curative effect to the mid-term of fracturing, traumatic injury treatment.Compare with the similar medicine in present market, pointed strong, according to the advantage of clinical disease, the side's of the choosing medication of course of disease length.
2. this preparation recipe principle: Radix Angelicae Sinensis sweet in the mouth, suffering, warm in nature, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving.Be used for blood deficiency and yellow complexion, rheumatic arthralgia, traumatic injury; Radix Dipsaci bitter in the mouth, suffering, slightly warm in nature, invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered.Be used for soreness of the waist and knees, rheumatic arthralgia, injury from falling down; Radix calophylli membranacei mildly bitter flavor, property are put down, and wind-damp dispelling are arranged, strengthening bone and muscle, the effect of promoting blood circulation and stopping pain.Cure mainly rheumatic arthritis, lumbago and skelalgia, traumatic injury; The Eupolyphaga Seu Steleophaga salty in the mouth, cold in nature.Removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones gathers benefiting vital QI and blood altogether, reunion of fractured tendons and bones, the effect of nourishing the liver and kidney.
3, each medicine of this preparation is in the scope of application of pharmacopeia and Guangxi medical material standard: Radix Angelicae Sinensis 6-12g, Eupolyphaga Seu Steleophaga 3-9g, Radix calophylli membranacei 533g, Pyritum 3-9g, Radix Dipsaci 9-15g.According to Chinese medicine " seven emotions " relation, the medication of prescription monarch produces synergism, and one day consumption of this preparation is: Radix Angelicae Sinensis 6g, Eupolyphaga Seu Steleophaga 2g, Radix calophylli membranacei 533g, Pyritum 2g, Radix Dipsaci 8g.。Use from the single medicinal material to the compatibility, passed through my institute and put into practice for a long time and progressively sum up, thereby be defined as best component proportion, clinical practice reaches optimum efficiency.It is the principal mode of middle medical drugs that the compatibility of medicine is used, and medicine is made up by certain law, and determines certain component proportion, makes appropriate dosage forms, also is the higher form that compatibility of drugs is used.
Curative effect judging standard:
1. cure: in damage 3-4 weeks of back, pain and local swelling are eliminated substantially.General soft tissue injury is repaired, and existing fibroid connects between fracture site, and callus begins to occur,
2. take a turn for the better: in damage 3-4 weeks of back, pain and local swelling are eliminated substantially.Existing fibroid connects between fracture site, and callus begins to occur, but not obvious.
3. do not heal: in damage 3-4 weeks of back, sings and symptoms does not improve.
Therapeutic outcome: in whole 100 example fracture patients in mid-term, take 1-2 months by above-mentioned usage and dosage after, pain and local swelling are eliminated substantially.General soft tissue injury is repaired, has fibroid between fracture site and connects, and callus begins to occur, and cures to account for 87%, takes a turn for the better 11%, does not heal 2%.
In addition, the inventor also uses 3 of No. 2 sheets of bonesetting that make among 2 and the embodiment 3 of No. 2 sheets of bonesetting that make among the embodiment 2 to carry out overtesting, and effect is also good, but the better effects if of No. 2 sheets that boneset is a little.
From above-mentioned experimental result as can be seen, No. 2 sheets of bonesetting of the present invention have curative effect preferably mid-term for fracturing, the clinical effect that has obtained satisfaction.
Claims (7)
1. an oral administration medicine for treating traumatic injury is characterized in that the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 300-500 mass parts, Eupolyphaga Seu Steleophaga 100-200 mass parts, Radix calophylli membranacei 500-600 mass parts, Pyritum 100-200 mass parts, Radix Dipsaci 500-600 mass parts.
2. according to the described oral administration medicine for treating traumatic injury of claim 1, it is characterized in that the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 400 mass parts, Eupolyphaga Seu Steleophaga 133 mass parts, Radix calophylli membranacei 533 mass parts, Pyritum 133 mass parts, Radix Dipsaci 533 mass parts.
3. the production method of an oral administration medicine for treating traumatic injury is characterized in that this method comprises following step:
(1) is ready to Radix Angelicae Sinensis 300-500 mass parts as raw material, Eupolyphaga Seu Steleophaga 100-200 mass parts, Radix calophylli membranacei 500-600 mass parts, Pyritum 100-200 mass parts, Radix Dipsaci 500-600 mass parts, (2) Radix Dipsaci 266 mass parts were ground into No. five sieve, 80 purpose fine powders are standby, (3) with above-mentioned Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix calophylli membranacei three flavors and remainder are not pulverized Radix Dipsaci and are decocted with water together, Pyritum decocts separately, merge two decocting liquids, it is evaporated to 50 ℃ time relative density is 1.35～1.40 thick paste, (4) above-mentioned standby Radix Dipsaci fine powder is added in the thick paste stirs, dry, pulverize, granulate, add appropriate amount of auxiliary materials, tabletting then.
4. according to the production method of the described traumatic injury treatment curative for oral use of claim 3, it is characterized in that wherein the proportioning of various material compositions is as follows: Radix Angelicae Sinensis 400 mass parts, Eupolyphaga Seu Steleophaga 133 mass parts, Radix calophylli membranacei 533 mass parts, Pyritum 133 mass parts, Radix Dipsaci 533 mass parts.
5. according to the production method of the described oral administration medicine for treating traumatic injury of claim 3, it is characterized in that in the step (3) three kinds of medical materials being decocted operation carries out in two steps, promptly, above-mentioned Radix Angelicae Sinensis, Eupolyphaga Seu Steleophaga, Radix calophylli membranacei three flavors and remainder are not pulverized Radix Dipsaci to be decocted with water together, Pyritum decocts separately, merge two decocting liquids, it is evaporated to 50 ℃ time relative density is 1.35～1.40 thick paste, (4) raw material fine powder and thick paste stir, that is, the Radix Dipsaci fine powder is added in the thick paste stirs, be dried, be ground into fine powder then, again pelletizing press sheet.
6. according to the production method of claim 3 or 5 described oral administration medicine for treating traumatic injury, it is characterized in that before the pelletizing press sheet of step (4), mix with fine powder earlier and mix and stir, carry out pelletizing press sheet again with the alcohol water blend of concentration 70-80%.
7. according to the production method of claims 3 described oral administration medicine for treating traumatic injury, the operation that decocts with water that it is characterized in that step (3) is carried out in two steps, 1.5-2 hour for the first time, 1～1.5 hour for the second time, twice decocting liquid merged, then it is evaporated to that relative density is the thick paste of 1.35-1.40 in the time of 50 ℃.
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| CN2008100737563A CN101361772B (en) | 2008-08-22 | 2008-08-22 | Oral medicine for treating traumatic injury and production method thereof |
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| CN2008100737563A CN101361772B (en) | 2008-08-22 | 2008-08-22 | Oral medicine for treating traumatic injury and production method thereof |
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| CN1883534A (en) * | 2006-05-22 | 2006-12-27 | 石景孟 | Medicine for treating orthopaedics disease and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883534A (en) * | 2006-05-22 | 2006-12-27 | 石景孟 | Medicine for treating orthopaedics disease and preparation method thereof |
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