CN101352343A - Alimentary canal intelligent drug release capsule system and method - Google Patents
Alimentary canal intelligent drug release capsule system and method Download PDFInfo
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- CN101352343A CN101352343A CNA2008100697119A CN200810069711A CN101352343A CN 101352343 A CN101352343 A CN 101352343A CN A2008100697119 A CNA2008100697119 A CN A2008100697119A CN 200810069711 A CN200810069711 A CN 200810069711A CN 101352343 A CN101352343 A CN 101352343A
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Abstract
The invention provides an enteron intelligent drug releasing capsule system and a method used for carrying out intelligent drug releasing of enteron of animal or human body. The system comprises a drug releasing electronic capsule and an information processing device; the drug releasing electronic capsule comprises a shell, a mini-typed battery, a sensor module, a drug releasing function module and a central control module; the parts are encapsulated inside the shell; the sensor module detects the physical chemistry or biochemical parameters inside the enteron with given time interval, and carries out the drug releasing intelligently according to the sensor module detection information. The system and the method of the invention can detect the physical chemistry or biochemical parameters of the enteron in real-time and control the drug releasing intelligently on the basis of the parameter processing, thus leading the drug to be released in the enteron within the best time and at the best position; the system and the method of the invention are novel noninvasine intelligent disease diagnosis and treatment system and method.
Description
Technical field:
The present invention relates to a kind of intelligent medicine releasing capsule system for digestive canal and method, be used for carrying out intellectual drug release, belong to the biomedical engineering technology field at the intestinal of animal or human's body.
Background technology:
Digestive tract diagnosis and treatment capsule system is the important directions of the technical development of digestive tract diagnosis and treatment in recent years.Development along with microelectric technique, portioned product with digestive tract diagnosis and treatment electronic capsule system of diagnosis and treatment function has entered clinical practice, and current techniques comprises the detection capsule of capsule endoscope with digestive tract camera function, digestive tract parameter detecting and has drug release remote controlled capsule of remote control drug release function etc.Calendar year 2001 Israel Given Imaging company takes the lead in having released clinical wireless endoscope M2A, the authentication of acquisition U.S. FDA, the M2A capsule endoscope is long to be 30mm, diameter is 11mm, utilizes the cmos image sensor images acquired, and picking rate was 2 auspicious/seconds, the special IC of its little power consumption guarantees that the M2A image acquisition was for up to 8 hours, the patient can free activity be the outstanding advantage of M2A during checking, and domestic Chongqing Kingsoft scientific ﹠ technical corporation has developed the OMOM capsule endoscope, has entered clinical practice.Medicine sustained release capsule system is the important branch in the digestive tract drug delivery system, be used under the monitoring of external special equipment and remote control, accurately realizing digestive tract specific part drug release, reason owing to technical costs, aspect clinical treatment, use less at present, mainly as the human body medicine Absorption Study instrument in the drug development, people such as Zheng of University Of Chongqing holt have carried out the research of drug release remote controlled capsule, and develop the practicability product.
In clinical, the part digestive tract disease needs topical to improve curative effect, reduces side effect, enteric hemorrhage for example, this disease often is positioned at the deep of intestinal, and traditional cable type endoscope is difficult to arrive this position, and may cause the intestinal wound during insertion.And current mainly based on the peroral dosage form of biomaterial, as various capsule preparations etc., can't discharge medicine exactly at the enteric hemorrhage position, be difficult to play excellent curative.In addition, current part controlled release preparation, although can be according to the variation of the acid-base value of intestinal and disintegrate, but, because the individual variation of human body is very big, and the influence factor of preparation disintegrate also not only has only influence factor of acid-base value, therefore causes currently changing the controlled release preparation that discharges medicine according to the digestive tract acid-base value and being difficult to reliable control.In addition, the site of pathological change of part digestive tract disease has biochemical character and change or the microorganism changing features, and current controlled release preparation is difficult to these variations of reliable response, can't discharge medicine at the position of the best.Therefore, press for a kind of identification digestive tract pathological changes feature that can intelligence, can discharge the novel enteron drug-supplying system of medicine in digestive tract pathological changes optimal treatment position.
Summary of the invention:
The objective of the invention is to overcome the deficiencies in the prior art, a kind of characteristic parameter and intelligent intelligent medicine releasing capsule system for digestive canal and method that discharges medicine that detects in the digestive tract is provided.
Technical scheme of the present invention is as described below:
Intelligent medicine releasing capsule system for digestive canal, comprise medicine releasing capsule, information processor, described medicine releasing capsule comprises shell, minicell, sensor assembly, the release functional module, central control module, above-mentioned component packages is portion in the enclosure, described sensor assembly is with physical chemistry or biochemical parameter in the interval detection digestive tract of setting, the outfan of sensor assembly is connected to the input of central control module, central control module and release functional module have the electronic signal connecting path, the release functional module comprises release driver and medicine holding bin, has the electronic signal connecting path between central control module and the information processor.
Information processor in the described technical scheme can be a mancarried device, comprise set of cells, on and off switch, data processing module, data memory module, signal wireless reception and transmitter module, antenna, data-interface, the central control module in the described medicine releasing capsule comprises radio signal emission and receiving chip.Information processor in the described technical scheme also can be an information processing chip, this information processing chip is packaged in the medicine releasing capsule, and the central control module in the described medicine releasing capsule has electronic signal circuit with described information processing chip and is connected.
Sensor assembly in the medicine releasing capsule that comprises in the described technical scheme comprises imageing sensor or comprises color sensor or comprise the hemoglobin detecting sensor or comprise acidity-basicity sensor or comprise temperature sensor or comprise pressure transducer or comprise microbiological sensor or the combination in any of the sensor.
Medicine releasing capsule can comprise a miniature magnetic switch in the described technical scheme.
In the described technical scheme, the release driver comprises micro-thruster, and described micro-thruster is little chemical propeller or micromechanics propeller.In the described technical scheme, the release functional module also can comprise release drive array and medicine holding bin array, and release drive array wherein comprises the micro-thruster array.
Be applicable to the digestive tract intelligent medicine releasing method of described intelligent medicine releasing capsule system for digestive canal, may further comprise the steps: (1) step 1, sensor assembly is with physical chemistry or biochemical parameter in the interval detection digestive tract of setting, (2) step 2, sensor assembly will detect information and pass to central control module in signal of telecommunication mode, (3) step 3, central control module passes to information processor with detection information, (4) step 4, information processor is analyzed and is handled detection information, (5) step 5, detection information is judged, if detection information is lower than pre-set threshold in the information processor, then repeat the step 1-4 of front, in case detection information reaches pre-set threshold in the information processor then enters step 6, (6) step 6, information processor is to a release control of the central control module output signal of telecommunication, (7) step 7, central control module receives this release control signal of telecommunication and controls under action of electric signals in this release, send the release control instruction to the release functional module, (8) step 8, the driver in the release functional module goes out medicine releasing capsule with the drug release in the medicine holding bin.
Described intelligent medicine releasing capsule system for digestive canal release method can also may further comprise the steps: when central control module sends the release control instruction to the release functional module, in the mode of radio signal to release index signal of external emission.
Work process of the present invention and principle are:
Carrying out intestinal release treatment with the patient is that example illustrates work process of the present invention and operation principle.Before treatment, the patient will carry out necessary preparations such as intestinal cleaning.Under doctor's guidance, patient's medicine releasing capsule of swallowing.After the release electronic capsule enters human body alimentary canal, sensor assembly is started working and is detected physical chemistry or biochemical parameter in the digestive tract with the interval of setting, these parameters may comprise image parameter or acid-base value parameter or pressure parameter or content of microorganisms etc., the perhaps combination of these parameters.The outfan of sensor assembly is connected to the input of central control module, sensor assembly will detect information and pass to central control module in signal of telecommunication mode, has the electronic signal connecting path between central control module and the information processor, central control module passes to information processor with detection information, information processor is analyzed and is handled detection information, if detection information is lower than pre-set threshold in the information processor, then repeat the step of front, in a single day detection information reach pre-set threshold in the information processor, information processor is to a release control of the central control module output signal of telecommunication, central control module receives this release control signal of telecommunication and controls under action of electric signals in this release, send the release control instruction to the release functional module, the driver in the release functional module goes out medicine releasing capsule with the drug release in the medicine holding bin.
The present invention compared with prior art, its outstanding technique effect is: system of the present invention and method thereof can detect parameters such as gastral physical chemistry and biochemistry in real time, control drug release intelligently on the basis that above-mentioned parameter is handled, thereby realize that medicine is released in the digestive tract in the time of the best, best position, having realized automatization, the intelligent processing procedure of detection, analytical judgment and drug release treatment in an integrated miniature diagnosis and therapy system, is a kind of novel noninvasive intelligent digestive tract disease diagnosis and therapy system and method.
Description of drawings:
Fig. 1 is a kind of composition sketch map of intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 2 is another composition sketch map of intelligent medicine releasing capsule system for digestive canal of the present invention, and information processing apparatus is changed to mancarried device.
Fig. 3 is another composition sketch map of intelligent medicine releasing capsule system for digestive canal of the present invention, and information processing apparatus is changed to the information processing chip and is packaged in the medicine releasing capsule.
Fig. 4 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 5 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 6 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 7 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 8 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Fig. 9 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 10 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 11 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 12 is a kind of composition sketch map of the sensor assembly in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 13 is the sensor module structure sketch map that comprises imageing sensor in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 14 is the sensor module structure sketch map that comprises color sensor in the intelligent medicine releasing capsule system for digestive canal of the present invention.
Figure 15 is a kind of composition sketch map of intelligent medicine releasing capsule system for digestive canal of the present invention, comprises miniature magnetic switch.
Figure 16 is a kind of schematic flow sheet of digestive tract intelligent medicine releasing method of the present invention.
Figure 17 is the another kind of schematic flow sheet of digestive tract intelligent medicine releasing method of the present invention.
In Fig. 1 to Figure 15:
The 1-medicine releasing capsule, 2-information processor, 3-shell, the 4-minicell, 5-sensor assembly, 6-release functional module, the 7-central control module, 8-release driver, 9-medicine holding bin, the 10-set of cells, 11-on and off switch, 12-data processing module, the 13-data memory module, the 14-signal wireless receives and transmitter module, the 15-antenna, the 16-data-interface, 17-imageing sensor, 18-color sensor, 19-hemoglobin detecting sensor, 20-acidity-basicity sensor, 21-temperature sensor, the 22-pressure transducer, the 23-microbiological sensor, the miniature luminescent device of 24-, 25-lens, 26-transparent optical cover, 27 miniature magnetic switchs
The specific embodiment:
The intelligent medicine releasing capsule system for digestive canal of present embodiment is whole to be formed as shown in Figure 1.Described intelligent medicine releasing capsule system for digestive canal comprises medicine releasing capsule 1, information processor 2, described medicine releasing capsule 1 comprises shell 3, minicell 4, sensor assembly 5, release functional module 6, central control module 7, and above-mentioned component packages is in shell 3 inside.Described sensor assembly 5 is with physical chemistry or biochemical parameter in the interval detection digestive tract of setting, the outfan of sensor assembly 5 is connected to the input of central control module 7, central control module 7 and release functional module 6 have the electronic signal connecting path, release functional module 6 comprises release driver 8 and medicine holding bin 9, has the electronic signal connecting path between central control module 7 and the information processor 2.
Among the embodiment, the sensor assembly 5 in the medicine releasing capsule 1 can comprise imageing sensor 17 or comprise color sensor 18 or comprise hemoglobin detecting sensor 19 or comprise acidity-basicity sensor 20 or comprise temperature sensor 21 or comprise pressure transducer 22 or comprise the combination in any of microbiological sensor 23 or the sensor.Because compound mode is numerous, differ in this manual and one enumerate, in Fig. 4 to Figure 12, provided several typical sensor compound modes.(1) as shown in Figure 4, sensor assembly 5 has comprised imageing sensor 17, hemoglobin detecting sensor 19, acidity-basicity sensor 20, temperature sensor 21, pressure transducer 22, microbiological sensor 23 totally 6 kinds of pick offs, the combination of above-mentioned multiple sensors, physical chemistry and biochemical parameter in the digestive tract that can obtain to enrich, by the analysis of multiple parameter, can obtain to judge more accurately to the pathological changes state in the digestive tract.(2) as shown in Figure 5, sensor assembly 5 has comprised imageing sensor 17,19 two kinds of pick offs of hemoglobin detecting sensor, the combination of described two kinds of pick offs, have best diagnosis effect for intestinal bleeding, judge from image information and two aspects of hemoglobin information whether intestinal hemorrhage situation occurs.(3) as shown in Figure 6, sensor assembly 5 has comprised imageing sensor 17, and the function of imageing sensor 17 is the images that obtain in the intestinal, in practice, consider that in the road intestinal be pitch-dark environment, therefore, with the miniature luminescent device of the supporting use of imageing sensor, be used for the illumination, generally can adopt micro-led, as shown in figure 13, sensor assembly 5 comprises miniature luminescent device 24, lens 25, transparent optical cover 26, imageing sensor are generally selected ccd image sensor or COMS imageing sensor for use.(4) as shown in Figure 7, sensor assembly 5 has comprised color sensor 18, in practice, in the same consideration road intestinal is pitch-dark environment, therefore with the miniature luminescent device of the supporting use of color sensor, as shown in figure 14, sensor assembly 5 comprises miniature luminescent device 24, transparent optical cover 26.(5) as shown in Figure 8, sensor assembly 5 has comprised hemoglobin detecting sensor 19.(6) as shown in Figure 9, sensor assembly 5 has comprised acidity-basicity sensor 20.(7) as shown in figure 10, sensor assembly 5 has comprised temperature sensor 21.(8) as shown in figure 11, sensor assembly 5 has comprised pressure transducer 22.(9) as shown in figure 12, sensor assembly 5 comprises microbiological sensor 23.The sensor all has corresponding clinical meaning in the digestive tract Clinical Laboratory, statement no longer one by one this time, in production, above-mentioned various pick off all has microminiaturized product, make and generate in the manufacturing concrete, can select the right sensors device according to the combination and the performance indications of pick off.Sensor assembly 5 is by minicell 4 energizes, and the data that sensor assembly 5 obtains pass to central control module 7, the work schedule of central control module 7 control sensor assemblies 5, sample frequency etc.
Present embodiment, release driver 8 can comprise micro-thruster, micro-thruster can be little chemical propeller or micromechanics propeller, micro-thruster have energy efficiency height, volume little, be easy to integrated advantage.In concrete enforcement, release functional module 6 also can comprise release drive array and medicine holding bin array, release drive array wherein comprises the micro-thruster array, the technique effect that utilizes the micro-thruster array is to carry out repeatedly drug release under the control of central control module 7, manufacturing about micro-thruster and micro-thruster array, can carry out based on current micro-system process technology, generally carry out based on bulk silicon process, current had sophisticated coherent reference technology.
Present embodiment provides the digestive tract intelligent medicine releasing that is applicable to intelligent medicine releasing capsule system for digestive canal method, specifically may further comprise the steps: (1) step 1, sensor assembly 5 is with physical chemistry or biochemical parameter in the interval detection digestive tract of setting.(2) step 2, sensor assembly 5 will detect information and pass to central control module 7 in signal of telecommunication mode.(3) step 3, central control module 7 passes to information processor 2 with detection information.In this step, if information processor 2 is for being positioned at external mancarried device, then this step comprises that central control module 7 will detect information and be emitted to externally in the mode of radio signal, is positioned at external information processor to receive this signal; Be packaged in the medicine releasing capsule 1 if information processor 2 is an information processing chip and this information processing chip, then in this step, central control module 7 directly will detect information and pass to the information processing chip by electronic signal circuit.(4) step 4,2 pairs of detection information of information processor are analyzed and are handled.(5) step 5, detection information is judged, if detection information is lower than pre-set threshold in the information processor, is then repeated the step 1-4 of front, in case detection information reaches pre-set threshold in the information processor then enters step 6.(6) step 6, information processor 2 is to a release control of the central control module 7 outputs signal of telecommunication.In this step, if information processor 2 is for being positioned at external mancarried device, then this step comprises that information processor 2 launches release control signal of telecommunication to central control module 7 in the mode of radio signal, and the radio signal receiving chip in the central control module 7 receives this signal; Be packaged in the medicine releasing capsule 1 if information processor 2 is an information processing chip and this information processing chip, then in this step, the information processing chip directly will detect information and pass to central control module 7 by electronic signal circuit.(7) step 7, central control module 7 receive this release control signal of telecommunication and under this release control action of electric signals, send the release control instruction to release functional module 6.(8) step 8, the release driver 8 in the release functional module 6 goes out medicine releasing capsule 1 with the drug release in the medicine holding bin 9.
The release method that is applicable to intelligent medicine releasing capsule system for digestive canal described in the embodiment can also may further comprise the steps: when central control module 7 sends the release control instruction to release functional module 6, in the mode of radio signal to release index signal of external emission.This release index signal can be positioned at external portable information processing device 2 and receive, and can be the information receiver of another one special use also, receives this release index signal and can be used to confirm that the drug release action carries out.
Claims (9)
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785673A (en) * | 2010-03-19 | 2010-07-28 | 重庆大学 | Intestinal tract diagnosis and treatment robot system |
| CN103418075A (en) * | 2012-05-21 | 2013-12-04 | 国际商业机器公司 | Method and system dispensing drugs from a companion diagnostic linked smart pill |
| US9131842B2 (en) | 2012-08-16 | 2015-09-15 | Rock West Solutions, Inc. | System and methods for locating relative positions of multiple patient antennas |
| CN106575470A (en) * | 2014-09-25 | 2017-04-19 | 英特尔公司 | Contextual activation of pharmaceuticals through wearable devices |
| CN107041727A (en) * | 2017-05-26 | 2017-08-15 | 杭州师范大学 | A kind of intelligent radio capsule and its control method |
| US10045713B2 (en) | 2012-08-16 | 2018-08-14 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
| CN110215179A (en) * | 2019-06-20 | 2019-09-10 | 京东方科技集团股份有限公司 | The medicament release device and capsule endoscope of capsule endoscope |
| CN111631674A (en) * | 2020-06-03 | 2020-09-08 | 湖北科技学院 | Drug-releasing capsule endoscope device and drug-releasing method |
| US10945635B2 (en) | 2013-10-22 | 2021-03-16 | Rock West Medical Devices, Llc | Nearly isotropic dipole antenna system |
| CN113967006A (en) * | 2021-10-29 | 2022-01-25 | 重庆大学 | A portable diabetic foot physiological parameter monitoring system |
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2008
- 2008-05-21 CN CNA2008100697119A patent/CN101352343A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785673A (en) * | 2010-03-19 | 2010-07-28 | 重庆大学 | Intestinal tract diagnosis and treatment robot system |
| CN103418075A (en) * | 2012-05-21 | 2013-12-04 | 国际商业机器公司 | Method and system dispensing drugs from a companion diagnostic linked smart pill |
| US10251553B2 (en) | 2012-05-21 | 2019-04-09 | International Business Machines Corporation | Dispensing drugs from a companion diagnostic linked smart pill |
| US10264972B2 (en) | 2012-05-21 | 2019-04-23 | International Business Machines Corporation | Dispensing drugs from a companion diagnostic linked smart pill |
| US9131842B2 (en) | 2012-08-16 | 2015-09-15 | Rock West Solutions, Inc. | System and methods for locating relative positions of multiple patient antennas |
| US11058322B2 (en) | 2012-08-16 | 2021-07-13 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
| US10045713B2 (en) | 2012-08-16 | 2018-08-14 | Rock West Medical Devices, Llc | System and methods for triggering a radiofrequency transceiver in the human body |
| US10945635B2 (en) | 2013-10-22 | 2021-03-16 | Rock West Medical Devices, Llc | Nearly isotropic dipole antenna system |
| CN106575470A (en) * | 2014-09-25 | 2017-04-19 | 英特尔公司 | Contextual activation of pharmaceuticals through wearable devices |
| CN107041727A (en) * | 2017-05-26 | 2017-08-15 | 杭州师范大学 | A kind of intelligent radio capsule and its control method |
| CN110215179A (en) * | 2019-06-20 | 2019-09-10 | 京东方科技集团股份有限公司 | The medicament release device and capsule endoscope of capsule endoscope |
| CN111631674A (en) * | 2020-06-03 | 2020-09-08 | 湖北科技学院 | Drug-releasing capsule endoscope device and drug-releasing method |
| CN113967006A (en) * | 2021-10-29 | 2022-01-25 | 重庆大学 | A portable diabetic foot physiological parameter monitoring system |
| CN113967006B (en) * | 2021-10-29 | 2023-09-26 | 重庆大学 | Portable diabetic foot physiological parameter monitoring system |
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