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CN101296896A - 盐酸加巴喷丁的制备方法 - Google Patents

盐酸加巴喷丁的制备方法 Download PDF

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Publication number
CN101296896A
CN101296896A CNA200680030240XA CN200680030240A CN101296896A CN 101296896 A CN101296896 A CN 101296896A CN A200680030240X A CNA200680030240X A CN A200680030240XA CN 200680030240 A CN200680030240 A CN 200680030240A CN 101296896 A CN101296896 A CN 101296896A
Authority
CN
China
Prior art keywords
dioxo
azaspiro
dicyano
hours
gabapentin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200680030240XA
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English (en)
Inventor
彭振云
朱伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nhwa Pharmaceutical Corp
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Nhwa Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nhwa Pharmaceutical Corp filed Critical Nhwa Pharmaceutical Corp
Publication of CN101296896A publication Critical patent/CN101296896A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种盐酸加巴喷丁制备方法，将1，5－二氰基－2，4－二氧代－3－氮杂螺[5，5]十一烷在65～85℃强酸条件下生成1，5－二氨甲酰基－2，4－二氧代－3－氮杂螺[5，5]十一烷，然后在碱性条件下进行霍夫曼重排；该方法原料易得、制备过程简单，可以减少对于中间体的提纯、生产成本较低、所得产品纯度较高。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CNA200680030240XA 2005-08-19 2006-04-28 盐酸加巴喷丁的制备方法 Pending CN101296896A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200510041536.9 2005-08-19
CNB2005100415369A CN100341856C (zh) 2005-08-19 2005-08-19 盐酸加巴喷丁制备方法
PCT/CN2006/000830 WO2007019752A1 (fr) 2005-08-19 2006-04-28 Procede de fabrication d'hydrochlorure de gabapentine

Publications (1)

Publication Number Publication Date
CN101296896A true CN101296896A (zh) 2008-10-29

Family

ID=36092709

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2005100415369A Active CN100341856C (zh) 2005-08-19 2005-08-19 盐酸加巴喷丁制备方法
CNA200680030240XA Pending CN101296896A (zh) 2005-08-19 2006-04-28 盐酸加巴喷丁的制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB2005100415369A Active CN100341856C (zh) 2005-08-19 2005-08-19 盐酸加巴喷丁制备方法

Country Status (4)

Country Link
US (1) US7667071B2 (zh)
EP (1) EP1939170B1 (zh)
CN (2) CN100341856C (zh)
WO (1) WO2007019752A1 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8043375B2 (en) 2008-03-06 2011-10-25 MoiRai Orthopaedic, LLC Cartilage implants
CN102690207B (zh) * 2012-05-31 2014-03-26 湖北楚阳科技股份有限公司 一种加巴喷丁的合成方法
CN104230735A (zh) * 2014-08-28 2014-12-24 太仓运通生物化工有限公司 一种加巴喷丁的制备方法
CN104151180A (zh) * 2014-08-28 2014-11-19 太仓运通生物化工有限公司 一种加巴喷丁盐酸盐的制备方法
CN109369530B (zh) * 2018-11-15 2022-03-04 河北三川化工有限公司 一种2,4-二氧-3-氮杂-螺[5,5]十一烷-1,5-二腈的制备方法
CN111116345A (zh) * 2019-12-30 2020-05-08 上海华理生物医药股份有限公司 一种制备Mirogabalin的新方法
CN112592289B (zh) * 2020-12-15 2022-09-20 内蒙古永太化学有限公司 一种加巴喷丁中间体的制备方法
CN114618409B (zh) * 2022-01-27 2023-07-18 中国计量大学 一种连续制备1-氧杂-2-氮杂螺[2，5]辛烷的微反应系统和方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1109017A (zh) 1994-03-25 1995-09-27 倪雪丰 长焊条接排机
ATE203933T1 (de) 1996-03-28 2001-08-15 Du Pont Verfahren zur herstellung von kugelförmigem mikroverbundmaterial
MXPA03003899A (es) 2000-11-02 2005-02-17 Teva Pharma Proceso mejorado para la produccion de intermedio de gabapentina.
CN1109017C (zh) * 2000-12-01 2003-05-21 杭州手心医药化学品有限公司 1,1－环己基二乙酸单酰胺的制备方法
IL144066A0 (en) 2001-06-28 2002-04-21 Bromine Compounds Ltd Process for the preparation of 1,1-cyclohexane diacetic monoamide
IL144063A0 (en) * 2001-06-28 2002-04-21 Bromine Compounds Ltd Process for the preparation of 1,1-cyclohexanediacetic acid
US20040034248A1 (en) 2002-04-16 2004-02-19 Taro Pharmaceutical Industries, Ltd. Process for preparing gabapentin
ITMI20022071A1 (it) * 2002-10-01 2004-04-02 Erregierre Spa Processo di sintesi dell'acido 1-(aminometil)cicloesanacetico cloridato.
ITMI20032165A1 (it) * 2003-11-11 2005-05-12 Zambon Spa Processo di preparazione di gabapentina
ITMI20041271A1 (it) 2004-06-24 2004-09-24 Zambon Spa Processo di preparazione di gabapentina

Also Published As

Publication number Publication date
US7667071B2 (en) 2010-02-23
CN1740161A (zh) 2006-03-01
WO2007019752A1 (fr) 2007-02-22
EP1939170A1 (en) 2008-07-02
EP1939170A4 (en) 2010-04-07
CN100341856C (zh) 2007-10-10
EP1939170B1 (en) 2017-07-12
US20090099362A1 (en) 2009-04-16

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Open date: 20081029