CN101280048B - Transparent aquagel having antibacterial action and preparation thereof - Google Patents

Abstract

A transparent hydrogel with antibacterial effect and its preparation method. The hydrogel is a copolymer of chitosan grafted on polyacrylic acid and/or acrylamide superabsorbent resin, wherein the content of chitosan is 3%-5% of the total weight of the hydrogel. Its preparation method: (1) synthesizing polyacrylic acid and/or acrylamide superabsorbent resin; (2) dissolving cerium ammonium nitrate in chitosan aqueous solution; (3) polyacrylic acid and/or acrylamide superabsorbent resin The water-absorbent resin is immersed in the chitosan solution; (4) under the condition of 30-95°C, the polyacrylic acid and/or acrylamide superabsorbent resin that has absorbed the chitosan solution containing ammonium cerium nitrate is placed in an infrared radiation box (5) The copolymer is rinsed with deionized water and chloroform to form a transparent biohydrogel with antibacterial effect. The hydrogel has good water retention performance and certain antibacterial properties. It will have a good development prospect as a soft contact lens.

Description

Transparent hydrogel with antibacterial effect and preparation method thereof

technical field

The invention relates to a transparent hydrogel with antibacterial effect and a preparation method thereof, belonging to the fields of new materials and biological materials.

Background technique

Chitosan is the most important derivative of the second largest polysaccharide in nature - chitin (Chitin). Positively charged linear polysaccharides can be prepared by deacetylating chitin by alkaline hydrolysis. The unique biological characteristics and physical and chemical properties of chitosan make it have potential broad application value in many aspects.

As a medicine for external use, chitosan has antibacterial properties, can promote the healing of skin tissue, and has the effects of repairing and hemostasis on damaged human epidermal tissue.

Chitosan can be made into biomaterials and applied to the human body, such as calcium phosphate bone cement/chitosan bone filling repair materials, hydroxyapatite/chitosan bone filling repair materials, calcium phosphate/chitosan porous bone tissue engineering materials, organic/chitosan composite bone repair materials, active growth factors/chitosan bone tissue engineering materials, chitosan soft tissue engineering materials, etc.

In ophthalmology, chitosan can be used in artificial tears, medical viscoelastics, implants for glaucoma surgery, and long-acting sustained-release preparations of ophthalmic drugs. Chitosan can also be used as an ophthalmic dressing. In animal experiments, it was found that chitosan has good compatibility with animal eye membranes, and can generate more collagen and fibroblasts, which is beneficial to the treatment of eye diseases.

The invention utilizes the antibacterial properties and water retention properties of chitosan to graft and modify the acrylic polymer under the action of initiator and infrared ray heating, thereby obtaining a transparent hydrogel with a certain antibacterial effect; as a biological material, The hydrogel can be used to make soft contact lenses and corneal contact lenses.

Contact lenses are divided into hard contact lenses, soft contact lenses and high oxygen permeability semi-rigid contact lenses. Hard contact lenses have good light transmission, but the small water content makes them uncomfortable to wear; while soft contact lenses have high water content and poor antibacterial effect, which creates environmental conditions for the growth of bacteria, and as a lens, it corrects corneal astigmatism , lens maintenance, and lens strength are not ideal; and high oxygen permeability semi-rigid contact lenses also have problems such as poor antibacterial properties.

There are many preparation methods for making contact lenses, and the patents related to this aspect are also very abundant, such as CN87104122, CN1045270, CN1048521, CN1055542, CN1175701, CN1234522. Most of the above-mentioned patented technologies adopt a polymerization process, that is, the polymerized monomers are polymerized in different ways in the presence of initiators and stabilizers. The polymerization methods used mainly include suspension polymerization, microsuspension polymerization, emulsion polymerization, reverse phase polymerization, dispersion polymerization and other methods.

Also some patents are about the improvement to the contact lens performance, as CN1537249, CN1902527, CN1914028, CN1436261, CN1254103, CN1255068, CN1321258, CN1294697. These patents focus on the oxygen permeability of superabsorbent resin, multi-focus function, overall coloring function, lens stability, reducing eye sensitivity caused by wearing lenses, and wearing aesthetics.

The aforementioned patents pay little attention to self-sterilizing contact lenses. Although some methods are involved, it is difficult for general laboratories or enterprises to realize the method of radiation body polymerization.

Contents of the invention

The object of the present invention is to provide a transparent hydrogel with antibacterial effect, which can be applied to many aspects such as contact lenses, and which is cheap to manufacture and safe to use.

Another object of the present invention is to provide a method for preparing a transparent hydrogel with antibacterial effect.

To achieve the above object, the present invention takes the following technical solutions:

A kind of transparent hydrogel with antibacterial effect, described hydrogel is the copolymer that chitosan is grafted on polyacrylic acid and/or acrylamide series superabsorbent resin, wherein, the content of chitosan is water 3% to 5% of the total weight of the gel.

In the antibacterial transparent hydrogel of the present invention, the polyacrylic acid and/or acrylamide superabsorbent resin is a polymer composed of acrylic acid and/or acrylamide monomers.

Among the above-mentioned acrylic acid and/or acrylamide monomers, there may be the following three combinations, including one monomer of acrylic acid; one monomer of acrylamide; two monomers of acrylic acid and acrylamide, wherein, acrylic acid The weight ratio between acrylamide and acrylamide is arbitrary.

In the monomers for the copolymerization of the polyacrylic acid and/or acrylamide superabsorbent resin, one or more comonomers of acrylate and hydroxyacrylate may also be included, and/or may include bis One or more cross-linking monomers selected from ethylene glycol acrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, and N,N-methylenebisacrylamide.

In the monomers of the polyacrylic acid and/or acrylamide superabsorbent resin copolymerized to form the above, the content of acrylic acid and/or acrylamide monomers is 80wt%-100wt%; one of acrylate and hydroxyacrylate or several comonomers, and/or one or several of ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylenebisacrylamide The cross-linking monomer content of the species is 0-20wt%.

The super absorbent resin referred to in polyacrylic acid and/or acrylamide super absorbent resin is also called super absorbent polymer (Super absorbent Polymers), abbreviated as SAP. It is a water-swellable polymer containing strong hydrophilic groups such as carboxyl and hydroxyl groups and has a certain degree of crosslinking. It is insoluble in water and organic solvents, and can absorb hundreds of times its own weight or even Thousand times of water, and the gel formed after absorbing water and swelling has good water retention and weather resistance. Once it absorbs water and expands into a hydrogel, it is difficult to separate the water even if it is pressurized.

Generally, the concepts of superabsorbent resin and water absorbent resin are equivalent, therefore, polyacrylic acid and/or acrylamide-based superabsorbent resin can also be called polyacrylic acid and/or acrylamide-based water-absorbent resin. However, superabsorbent resin places more emphasis on the water absorption of the resin. It is a functional polymer material with a particularly strong water absorption capacity. The general water absorption multiple is hundreds or even thousands of times. ; The water absorption rate of superabsorbent resin has increased from a hundred times in the 1980s to four or five thousand times at present. At present, polyacrylate superabsorbent resin is dominant in the world.

A kind of production method of the transparent hydrogel with antibacterial effect, this method comprises the following steps:

(1) first synthesize polyacrylic acid and/or acrylamide superabsorbent resin, and dry;

(2) dissolving ammonium cerium nitrate in the chitosan aqueous solution, wherein the concentration of the chitosan aqueous solution is 4wt%～6wt%, and the addition of ceric ammonium nitrate is 0.5%～1.5wt% relative to the chitosan aqueous solution ;

(3) Immerse the dried polyacrylic acid and/or acrylamide superabsorbent resin mentioned in (1) into the chitosan aqueous solution mentioned in (2), and the immersion time is 24h～30h;

(4) Under the condition of 30～95 DEG C, the polyacrylic acid and/or acrylamide series superabsorbent resin which has adsorbed the chitosan aqueous solution containing ammonium cerium nitrate in (3) is placed in an infrared radiation box to initiate polymerization to obtain copolymer;

(5) Rinse the reacted copolymer in (4) with deionized water and chloroform to form a transparent biological hydrogel with antibacterial effect.

In the production method of the transparent hydrogel with antibacterial effect of the present invention, continue to immerse the chitosan aqueous solution mentioned in (2) after the copolymer after the reaction in (4) is dried, the time of immersion is 24h ~30h; and repeat (4), (5) steps.

In the production method of the transparent hydrogel with antibacterial effect of the present invention, in the step (1), whether or not there is acrylic acid in the monomer involves the problem of whether or not to add NaOH aqueous solution. The monomer adopts acrylic acid, or mainly adopts acrylic acid monomer, or adopts mainly acrylic acid and acrylamide monomer, and NaOH aqueous solution must be added dropwise, which is the following dropwise NaOH aqueous solution to prepare polyacrylic acid (or polyacrylic acid) and acrylamide-based) superabsorbent resin method. The monomer does not use acrylic acid, but uses acrylamide, or uses acrylamide as the main monomer without using acrylic acid, so there is no need to add NaOH aqueous solution dropwise, that is, the following method does not need to add NaOH aqueous solution to prepare polyacrylamide-based high-grade The method of water-absorbent resin.

The method for preparing polyacrylic acid superabsorbent resin by adding NaOH aqueous solution dropwise:

In the step (1), the polyacrylic acid series (or polyacrylic acid and acrylamide series) superabsorbent resin is synthesized by using acrylic acid monomers, and NaOH aqueous solution is added dropwise to the above monomers for neutralization, and the degree of neutralization is 75%, and then add ammonium persulfate to the above-mentioned monomers, wherein the ratio of the parts by weight of the above-mentioned monomers to the number of parts by weight of ammonium persulfate is 100:1. When the mixture changes from a white turbid gel to a transparent gel, the reaction is stopped, and a polyacrylic (or polyacrylic and acrylamide) superabsorbent resin is synthesized.

Wherein, the concentration range of the NaOH aqueous solution is 10wt%-40wt%.

In the step (1), in the above-mentioned synthesis of polyacrylic superabsorbent resin using acrylic acid monomers, the monomers used also include one or more of acrylamide, acrylate hydroxyl ester, and acrylate Comonomer, and/or cross-linking of one or more of ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylenebisacrylamide monomer. Among them, acrylic acid (in the case of no acrylamide in the monomer), or acrylic acid and acrylamide (in the case of acrylamide in the monomer) accounts for 80wt%-100wt% of the total monomer content; acrylate, acrylic acid One or more comonomers of hydroxy esters, and/or ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylenebisacrylamide One or more of the cross-linking monomers account for 0-20wt% of the total monomer content. That is to say, if it is a monomer, it must be acrylic acid; if other above-mentioned monomers are included, it is mainly acrylic acid monomer, or acrylic acid and acrylamide.

Method for preparing polyacrylamide-based superabsorbent resin without adding NaOH aqueous solution dropwise:

In the step (1), acrylamide is used to synthesize polyacrylamide-based superabsorbent resin, and then ammonium persulfate is added to the above-mentioned monomers, wherein the parts by weight of the above-mentioned monomers and the weight of ammonium persulfate The ratio of parts is 100:1. After mixing evenly, the temperature starts to rise to 50°C-90°C. When the reaction mixture changes from white turbid gel to transparent gel, the reaction is stopped, and polyacrylamide superabsorbent resin is synthesized.

In the step (1), the monomers for synthesizing polyacrylamide-based superabsorbent resins also include one or more comonomers of hydroxyl acrylate and acrylate, and/or ethylene diacrylate Alcohol ester, butylene glycol diacrylate, trimethylolpropane triacrylate, N, N-methylene bisacrylamide or one or more crosslinking monomers. Among them, acrylamide accounts for 80wt%-100wt% of the total monomer content; one or more comonomers in acrylate, hydroxyacrylate, and/or ethylene glycol diacrylate, butylene glycol diacrylate One or more cross-linking monomers of ester, trimethylolpropane triacrylate, N,N-methylenebisacrylamide account for 0-20wt% of the total monomer content. That is to say, if it is a monomer, it must be acrylamide; if it includes other above-mentioned monomers, it is mainly acrylamide monomer, excluding acrylic acid.

In the reaction of the monomer and ammonium persulfate, after mixing the monomer and ammonium persulfate uniformly in the reactor, the reaction material is heated to 50°C-90°C. This reaction is an exothermic reaction. When the reaction starts to exotherm, pay attention to controlling the reaction temperature between 50°C and 90°C.

The advantages of the present invention are:

Advantages and positive effects of the invention:

In the transparent hydrogel with antibacterial effect of the present invention, polyacrylic acid and/or acrylamide-based macromolecules are hydrophilic due to the large amount of hydrophilic groups contained in their skeletons. Cross-linked polyacrylic resins with different degrees of cross-linking will not dissolve after absorbing water, but will swell into a hydrogel, which has the superior performance of rapidly absorbing and retaining a large amount of water while being insoluble in water. After the water-soluble chitosan is grafted onto the polyacrylic acid and/or acrylamide superabsorbent resin, the product is a transparent gel. It not only has good water retention performance, but also has certain antibacterial properties. In the field of biomedical materials, this polymer can have a moisture content close to that of physiological tissues, and has good biocompatibility. It will have a good development prospect as a soft contact lens.

The synthesis method of the present invention is simple. Under the action of cerium ammonium nitrate, the water-soluble chitosan can be grafted and polymerized with water-soluble acrylic acid and acrylic acid ester by infrared heating, and the water-soluble chitosan can be combined with non- Water-soluble acrylate undergoes graft polymerization, so that the product can have the properties of two compounds.

Description of drawings

FIG. 1 is an infrared spectrogram of polyacrylic acid and acrylamide-based superabsorbent resin used in Example 1.

Fig. 2 is the infrared spectrogram of chitosan.

Fig. 3 is the infrared spectrogram of the polyacrylic acid and acrylamide superabsorbent resin grafted with chitosan prepared in Example 1 (that is, the transparent hydrogel with antibacterial effect prepared in Example 1).

Detailed ways

The technical scheme for preparing a transparent hydrogel with a certain antibacterial effect comprises the following steps:

1) Add one or more comonomers of acrylic acid, acrylate, hydroxy acrylate, acrylamide (but must contain acrylic acid and/or acrylamide) and ethylene glycol diacrylate, diacrylic acid to the reactor A total of 100 parts by weight of one or more cross-linking monomers of butanediol ester, trimethylolpropane triacrylate, and N,N-methylenebisacrylamide. If there is acrylic acid in the above-mentioned comonomers, NaOH aqueous solution needs to be added dropwise for neutralization, and the degree of neutralization is 75%; if there is no acrylic acid in the above-mentioned comonomers, step 2) is directly carried out.

2) Then add 1 part by weight of ammonium persulfate, and start to heat up after mixing evenly, and the reaction temperature is between 50°C and 90°C.

3) When the temperature is raised and the reaction mixture changes from a white turbid gel to a transparent gel, the reaction is stopped.

4) Take out the gel, put it on a watch glass, chop it up and put it in an oven to dry.

5) Prepare chitosan aqueous solutions with different concentrations, and dissolve cerium ammonium nitrate in the chitosan aqueous solution simultaneously.

6) Immerse the dried polymer in step 4) in the chitosan aqueous solution in step 5), and place it for 24 hours.

7) Put the gel in step 6) in an infrared oven, and perform graft polymerization at 30-95° C. for 8 hours.

8) The polymer after grafting is rinsed repeatedly with deionized water and chloroform to remove unreacted monomers, and a transparent hydrogel containing chitosan can be obtained.

In the following examples, the content of chitosan in the resulting hydrogel is tested by gravimetric method, that is, under the condition of a certain total amount of substances, unreacted chitosan is removed by extraction with water and solvent The quality of the obtained chitosan quality, the quality of the graft copolymer, so as to calculate the content of chitosan in the hydrogel.

Example 1

Add 100 parts by weight of acrylic acid and acrylamide into the reactor, start electromagnetic stirring; add NaOH aqueous solution dropwise for neutralization, and the neutralization degree is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

It should be noted that, in 100 parts by weight of acrylic acid and acrylamide, the weight ratio between acrylic acid and acrylamide is arbitrary. In Example 1, the weight ratio of acrylic acid and acrylamide is 1:1.

Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel is taken out and dried in an oven to obtain polyacrylic acid and acrylamide-based superabsorbent resin. The infrared spectrograms of polyacrylic acid and acrylamide superabsorbent resin are shown in Figure 1.

Configuration concentration is the chitosan aqueous solution of 5wt%, and the infrared spectrum of the chitosan adopted is as shown in Figure 2. And at the same time, 1 wt% ammonium cerium nitrate relative to the chitosan aqueous solution was added. The weighed dry polyacrylic acid and acrylamide-based superabsorbent resin were immersed in an aqueous chitosan solution with a concentration of 5 wt % and placed for 24 hours.

The gel was taken out, placed in an infrared oven, and grafted and polymerized at 95°C.

The grafted polymer is placed in deionized water and repeatedly rinsed to remove unreacted water-soluble chitosan and acrylic acid and acrylamide monomers, and the transparent hydrogel with antibacterial effect of the present invention is made. The infrared spectrum of the gel is shown in Figure 3. In Figure 3, the bands with wavenumbers around 1549 can be attributed to the carbonyl vibration of carboxylate; the bands with wavenumbers around 3408 and 1084 can be attributed to the O-H stretching and C-OH deformation vibrations of hydroxyl groups, indicating the presence of chitosan.

The content of chitosan in the hydrogel can reach 3%, which can inhibit the growth of mold.

Example 2

Add 85 parts by weight of acrylic acid, 10 parts by weight of methyl methacrylate, and 5 parts by weight of N,N-methylene bisacrylamide into the reactor, start electromagnetic stirring; add NaOH aqueous solution dropwise for neutralization, neutralization The degree is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylic acid-based superabsorbent resin was immersed in an aqueous chitosan solution with a concentration of 5 wt % and placed for 24 hours.

The gel was taken out, placed in an infrared oven, and grafted and polymerized at 95°C.

The grafted polymer is placed in deionized water and rinsed repeatedly to remove unreacted water-soluble chitosan and acrylic acid, methyl methacrylate, N, N-methylenebisacrylamide monomers, and then the The transparent hydrogel with antibacterial effect of the present invention.

The content of chitosan in the hydrogel can reach 3%, which can inhibit the growth of mold.

Example 3

Add 85 parts by weight of acrylic acid, 10 parts by weight of hydroxyethyl acrylate, and 5 parts by weight of ethylene glycol diacrylate into the reactor, start electromagnetic stirring; dropwise add NaOH aqueous solution for neutralization, and the degree of neutralization is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylic acid-based superabsorbent resin was immersed in an aqueous chitosan solution with a concentration of 5 wt % and placed for 24 hours.

The gel was taken out, placed in an infrared oven, and grafted and polymerized at 95°C.

The grafted polymer is placed in deionized water and repeatedly rinsed to remove unreacted water-soluble chitosan and acrylic acid, hydroxyethyl acrylate, and ethylene glycol diacrylate monomers, and the antibacterial antibacterial agent of the present invention is made. transparent hydrogel.

The content of chitosan in the hydrogel can reach 3%, which can inhibit the growth of mold.

Example 4

A total of 100 parts by weight of acrylamide and N, N-methylenebisacrylamide were added into the reactor, wherein, acrylamide was 85 parts by weight, and N, N-methylenebisacrylamide was 15 parts by weight; After the ammonium persulfate in parts by weight is uniformly mixed, the temperature rise reaction is started, and the reaction temperature is controlled between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylamide-based superabsorbent resin was immersed in an aqueous chitosan solution with a concentration of 5 wt % and placed for 24 hours.

The gel was taken out, placed in an infrared oven, and grafted and polymerized at 40°C.

The grafted polymer is placed in deionized water and rinsed repeatedly to remove unreacted water-soluble chitosan and acrylamide, N, N-methylenebisacrylamide monomer, which is to make the antibacterial transparent hydrogel.

The content of chitosan in the hydrogel can reach 3%, which can inhibit the growth of mold.

Example 5

In the reactor, add 85 parts by weight of acrylamide, 10 parts by weight of hydroxyethyl acrylate, 5 parts by weight of trimethylolpropane triacrylate, and 1 part by weight of ammonium persulfate, start the temperature rise reaction after mixing, control The reaction temperature is between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylamide-based superabsorbent resin was immersed in a chitosan aqueous solution with a concentration of 5 wt % and placed for 24 hours.

The gel was taken out, placed in an infrared oven, and grafted and polymerized at 40°C.

The grafted polymer is placed in deionized water and rinsed repeatedly to remove unreacted water-soluble chitosan and acrylamide, hydroxyethyl acrylate, and trimethylolpropane triacrylate monomers, which are made into the present invention. transparent hydrogel with antibacterial properties.

The content of chitosan in the hydrogel can reach 3%, which can inhibit the growth of mold.

Claims (4)

1. the production method of the transparent hydrogel with antibacterial effect is characterized in that, the method comprises the following steps: (1) first synthesize polyacrylic acid superabsorbent resin and/or polyacrylamide superabsorbent resin, and dry; (2) dissolving ammonium cerium nitrate in the chitosan aqueous solution, wherein the concentration of the chitosan aqueous solution is 4wt%～6wt%, and the addition of ceric ammonium nitrate is 0.5%～1.5wt% relative to the chitosan aqueous solution ; (3) Immerse the dried polyacrylic acid and/or acrylamide superabsorbent resin mentioned in (1) into the chitosan aqueous solution mentioned in (2), and the immersion time is 24h～30h; (4) Under the condition of 30-95°C, place the polyacrylic acid superabsorbent resin and/or the polyacrylamide superabsorbent resin that has absorbed the chitosan solution containing ammonium cerium nitrate in (3) under infrared radiation Initiate polymerization in the box to obtain a copolymer; (5) The copolymer reacted in (4) is rinsed with deionized water and chloroform, which is a transparent biological hydrogel with antibacterial effect; in: In the step (1), a polyacrylic acid-based superabsorbent resin is synthesized by using monomers including acrylic acid, and NaOH aqueous solution is added dropwise to the above-mentioned monomers for neutralization, and the degree of neutralization is 75%, and then the above-mentioned monomers Ammonium persulfate was added to the mixture, wherein the ratio of the parts by weight of the above-mentioned monomers to the parts by weight of ammonium persulfate was 100:1, and after mixing evenly, the temperature was raised to 50°C-90°C, and the reaction mixture changed from a white turbid gel to a When the gel is transparent, stop the reaction and synthesize polyacrylic acid superabsorbent resin; Alternatively, in the step (1), a polyacrylamide-based superabsorbent resin is synthesized using monomers including acrylamide, and then ammonium persulfate is added to the monomers, wherein the parts by weight of the monomers and The weight ratio of ammonium persulfate is 100:1. After mixing evenly, the temperature starts to rise to 50°C-90°C. When the reaction mixture changes from a white turbid gel to a transparent gel, stop the reaction and synthesize a polyacrylamide-based superabsorbent Sexual resin. 2. the production method of the transparent hydrogel with antibacterial effect according to claim 1 is characterized in that, after the copolymer after the reaction in (4) is dried, continue to immerse the chitosan described in (2) Aqueous solution, immersion time is 24h～30h; And repeat (4), (5) steps. 3. the production method of the transparent hydrogel with antibacterial effect according to claim 1, is characterized in that, in described step (1), in the monomer of synthesizing polyacrylic acid superabsorbent resin, also comprise propylene One or more comonomers of amide, hydroxy acrylate, acrylate, and/or ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N- One or more cross-linking monomers in methylene bisacrylamide, wherein acrylic acid, or acrylic acid and acrylamide account for 80wt%-100wt% of the total monomer content; one of acrylate and hydroxyacrylate One or more comonomers, and/or one or more of ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylenebisacrylamide Several crosslinking monomers account for 0-20 wt% of the total monomer content. 4. the production method of the transparent hydrogel with antibacterial effect according to claim 1, is characterized in that, in described step (1), in the monomer of synthesizing polyacrylamide superabsorbent resin, also include One or several comonomers of hydroxy acrylate and acrylate, and/or ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylene One or more cross-linking monomers of bisacrylamide; among them, acrylamide accounts for 80wt%-100wt% of the total monomer content; one or more copolymerization monomers of acrylate and hydroxy acrylate body, and/or one or more cross-linking monomers of ethylene glycol diacrylate, butylene glycol diacrylate, trimethylolpropane triacrylate, N,N-methylenebisacrylamide Accounting for 0-20wt% of the total monomer content.

Images