CN101264314A - Medicaments assembly for clearing heat and detoxication, activating blood circulation and removing stasis, and diminishing inflammation and reducing pain - Google Patents
Medicaments assembly for clearing heat and detoxication, activating blood circulation and removing stasis, and diminishing inflammation and reducing pain Download PDFInfo
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- CN101264314A CN101264314A CNA200810105824XA CN200810105824A CN101264314A CN 101264314 A CN101264314 A CN 101264314A CN A200810105824X A CNA200810105824X A CN A200810105824XA CN 200810105824 A CN200810105824 A CN 200810105824A CN 101264314 A CN101264314 A CN 101264314A
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Abstract
The invention discloses a composite medicine having the functions of heat-clearing and detoxifying, anti-inflaminatory and pain-relief and activating blood circulation to dissipate blood stasis. The active ingredients for the medicine are extracted from a plurality of medicinal materials: radix aconiti preparata, evodia eutaecarpa, largehead atractylodes rhizome, angelica sinensis, rhizome ligustici wallichii, epimedium, Chinese mugwort leaves, leonurus japonicus, coix seed, rhizome corydalis, cyathula root, cassia twig, atractylodes, poria cocos, dried ginger, and turmeric root-tuber. The special active components in the invention has the functions of heat-clearing and detoxifying, anti-inflaminatory and pain-relief, activating blood circulation to dissipate blood stasis and regulating incretion; the medicine is suitable for illness with the evidences of women dysmenorrhea or amenorrhea.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to the drug regimen of a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic.
Technical background
Dysmenorrhea is divided primary dysmenorrhea and secondary dysmenorrhea two classes.Primary dysmenorrhea is most commonly in the unmarried women who does not produce below 25 years old, generally after menophania, took place in 6-12 month, and mostly to reproduction age, can alleviate after marriage, even transference cure.Be not need the normal physiological phenomena for the treatment of.
And secondary dysmenorrhea has the clear and definite cause of disease, is common in the women of child-bearing age, the married woman after 30 years old particularly, and organic disease has taken place in its genitals, and gynecologial examination can be found uterus increase, limitation of activity, tenderness is arranged; Adnexa increases thick or lamellar thickens, has tenderness.Must by symptomatic treatment,, could eliminate the dysmenorrhea symptom to regular examination in hospital until the protopathy recovery from illness.
Secondary dysmenorrhea is the symptom of various gynecological diseases, modal endometriosis, chronic pelvic inflammatory disease, the chronic cervicitis etc. of comprising.Wherein the pain that causes with endometriosis especially is the most violent, must go hospitalize, if incured loss through delay best occasion for the treatment, probably causes infertile.And all be common gynaecopathia as pelvic inflammatory disease, cervicitis, with repeatedly and might cause malignant change, brought great misery to the female friend.
The traditional Chinese medical science is thought: " man is based on kidney, and the woman is based on blood ".Women's QI and blood is in harmonious proportion, and endocrine is just normal, just dysmenorrhea not in the period, and health is just healthy.Can postpone delay involutional.The women of general health, facial gloss is ruddy, does not have pimple and chloasma.Blood conditioning as the women is bad, the endocrine disturbance, lose in treatment, delay the state of an illness, will a lot of problems appear adolescence, period of duration, climacteric, as: dysmenorrhea, menoxenia, endocrine disturbance, comedo, chloasma, chronic pelvic inflammatory disease, hysteromyoma, endometriosis, pelvic cavity congestion syndrome, chocolate cyst, adnexitis, obstruction of fallopian tube, uterine hypoplasia, infertility, climacteric are waited in advance, and serious will cause lifelong regretting.
Motherland's medical science is thought: " dysmenorrhea and infertile relation are very close, according to clinical observation, have more than half with the different dysmenorrhea of light and heavy degree in the infertile patient approximately.By proposing after a large amount of analysis of clinical data, account for 56% with dysmenorrhea person in the infertility, and find dysmenorrhea in case eliminate, the patient also becomes pregnant immediately.The viewpoint that this shows that dysmenorrhea and infertile relation are very close really, also show ancients' what is called simultaneously " regulating menstruation of seed elder generation is through transferring pregnant having of one's own " is correct.The cyclomastopathy traditional Chinese medical science is referred to as " nodules of the breast ".Its clinical characters be one-sided or the bilateral breast in lump is arranged, slightly have a pain at ordinary times or not bitterly, generally there is the lump increase time of tide and has a pain or increase the weight of, the women between 20～40 years old of mostly occurring in the future in menstruation.From clinical observation, there is the dysmenorrhea patient more than 1/3 comparatively close approximately with the relation of cyclomastopathy and dysmenorrhea.″
Therefore, the treatment dysmenorrhea is instant to the patient, the drug main that is used for the treatment of dysmenorrhea in the market will be based on analgesic, the pain relieving to the ill of doctor trained in Western medicine is easy to generate drug resistance and the hormone therapy side effect is big, analgesic more can cause the nervous function disorder, adverse consequencess such as memory reduction, insomnia.The present invention has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, endocrine regulation, generally begins to take in the last week that menstruation comes, and effective alleviating pain, and side effect is little.
Summary of the invention:
One of purpose of the present invention provides the drug regimen of a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1, prescription:
Radix Aconiti Lateralis Preparata 100-300 part Fructus Evodiae 80-240 part Rhizoma Atractylodis Macrocephalae 80-240 part
Radix Angelicae Sinensis 100-300 part Rhizoma Chuanxiong 100-300 part Herba Epimedii 80-240 part
Folium Artemisiae Argyi 80-240 part Herba Leonuri 80-240 part Semen Coicis 80-240 part
Rhizoma Corydalis 100-300 part Radix Cyathulae 100-300 part Ramulus Cinnamomi 80-240 part
Rhizoma Atractylodis 80-240 part Poria 100-300 part Rhizoma Zingiberis 80-240 part
Radix Curcumae 80-240 part
The active component that preferred following raw materials according is made, curative effect is better:
160 parts of 160 parts of Rhizoma Atractylodis Macrocephalaes of 200 parts of Fructus Evodiaes of Radix Aconiti Lateralis Preparata
160 parts of 200 parts of Herba Epimedii of 200 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
160 parts of 80 parts of Semen Coiciss of 80 parts of Herba Leonuris of Folium Artemisiae Argyi
160 parts of 200 parts of Ramulus Cinnamomi of 200 portions of Radix Cyathulaes of Rhizoma Corydalis
80 parts of 200 portions of Rhizoma Zingiberiss of 160 parts of Poria of Rhizoma Atractylodis
80 parts of Radix Curcumaes
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Aconiti Lateralis Preparata, Fructus Evodiae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Folium Artemisiae Argyi, Herba Leonuri, Semen Coicis, Rhizoma Corydalis, Radix Cyathulae, Ramulus Cinnamomi, Rhizoma Atractylodis, Poria, Rhizoma Zingiberis, Radix Curcumae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, endocrine regulation.Be used for cards such as menalgia, amenorrhea.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1, prescription:
160 parts of 160 parts of Rhizoma Atractylodis Macrocephalaes of 200 parts of Fructus Evodiaes of Radix Aconiti Lateralis Preparata
160 parts of 200 parts of Herba Epimedii of 200 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
160 parts of 80 parts of Semen Coiciss of 80 parts of Herba Leonuris of Folium Artemisiae Argyi
160 parts of 200 parts of Ramulus Cinnamomi of 200 portions of Radix Cyathulaes of Rhizoma Corydalis
80 parts of 200 portions of Rhizoma Zingiberiss of 160 parts of Poria of Rhizoma Atractylodis
80 parts of Radix Curcumaes
2. preparation technology
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Aconiti Lateralis Preparata, Fructus Evodiae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Folium Artemisiae Argyi, Herba Leonuri, Semen Coicis, Rhizoma Corydalis, Radix Cyathulae, Ramulus Cinnamomi, Rhizoma Atractylodis, Poria, Rhizoma Zingiberis, Radix Curcumae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1, prescription:
160 parts of 160 parts of Rhizoma Atractylodis Macrocephalaes of 200 parts of Fructus Evodiaes of Radix Aconiti Lateralis Preparata
160 parts of 200 parts of Herba Epimedii of 200 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
160 parts of 80 parts of Semen Coiciss of 80 parts of Herba Leonuris of Folium Artemisiae Argyi
160 parts of 200 parts of Ramulus Cinnamomi of 200 portions of Radix Cyathulaes of Rhizoma Corydalis
80 parts of 200 portions of Rhizoma Zingiberiss of 160 parts of Poria of Rhizoma Atractylodis
80 parts of Radix Curcumaes
2. preparation technology
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Aconiti Lateralis Preparata, Fructus Evodiae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Folium Artemisiae Argyi, Herba Leonuri, Semen Coicis, Rhizoma Corydalis, Radix Cyathulae, Ramulus Cinnamomi, Rhizoma Atractylodis, Poria, Rhizoma Zingiberis, Radix Curcumae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
160 parts of 160 parts of Rhizoma Atractylodis Macrocephalaes of 200 parts of Fructus Evodiaes of Radix Aconiti Lateralis Preparata
160 parts of 200 parts of Herba Epimedii of 200 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
160 parts of 80 parts of Semen Coiciss of 80 parts of Herba Leonuris of Folium Artemisiae Argyi
160 parts of 200 parts of Ramulus Cinnamomi of 200 portions of Radix Cyathulaes of Rhizoma Corydalis
80 parts of 200 portions of Rhizoma Zingiberiss of 160 parts of Poria of Rhizoma Atractylodis
80 parts of Radix Curcumaes
2. preparation technology
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Aconiti Lateralis Preparata, Fructus Evodiae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Folium Artemisiae Argyi, Herba Leonuri, Semen Coicis, Rhizoma Corydalis, Radix Cyathulae, Ramulus Cinnamomi, Rhizoma Atractylodis, Poria, Rhizoma Zingiberis, Radix Curcumae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the drug regimen of a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Aconiti Lateralis Preparata 100-300 part Fructus Evodiae 80-240 part Rhizoma Atractylodis Macrocephalae 80-240 part
Radix Angelicae Sinensis 100-300 part Rhizoma Chuanxiong 100-300 part Herba Epimedii 80-240 part
Folium Artemisiae Argyi 80-240 part Herba Leonuri 80-240 part Semen Coicis 80-240 part
Rhizoma Corydalis 100-300 part Radix Cyathulae 100-300 part Ramulus Cinnamomi 80-240 part
Rhizoma Atractylodis 80-240 part Poria 100-300 part Rhizoma Zingiberis 80-240 part
Radix Curcumae 80-240 part
2, the drug regimen of a kind of heat-clearing and toxic substances removing according to claim 1, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
160 parts of 160 parts of Rhizoma Atractylodis Macrocephalaes of 200 parts of Fructus Evodiaes of Radix Aconiti Lateralis Preparata
160 parts of 200 parts of Herba Epimedii of 200 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
160 parts of 80 parts of Semen Coiciss of 80 parts of Herba Leonuris of Folium Artemisiae Argyi
160 parts of 200 parts of Ramulus Cinnamomi of 200 portions of Radix Cyathulaes of Rhizoma Corydalis
80 parts of 200 portions of Rhizoma Zingiberiss of 160 parts of Poria of Rhizoma Atractylodis
80 parts of Radix Curcumaes
3, according to the drug regimen of the described a kind of heat-clearing and toxic substances removing of claim 1-2, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, it is characterized in that adopting following method to make:
(1) Radix Angelicae Sinensis, Rhizoma Chuanxiong add 80% alcohol dipping secondary, flood 48 hours for the first time, flood 24 hours for the second time, filter, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Radix Aconiti Lateralis Preparata, Fructus Evodiae, the Rhizoma Atractylodis Macrocephalae, Herba Epimedii, Folium Artemisiae Argyi, Herba Leonuri, Semen Coicis, Rhizoma Corydalis, Radix Cyathulae, Ramulus Cinnamomi, Rhizoma Atractylodis, Poria, Rhizoma Zingiberis, Radix Curcumae add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the drug regimen of any one described a kind of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the drug regimen of the described a kind of heat-clearing and toxic substances removing of claim 3-4, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205103A (en) * | 2011-05-13 | 2011-10-05 | 葛晓云 | Pure Chinese medicinal plaster for treating dysmenorrhea |
| CN103316263A (en) * | 2013-07-03 | 2013-09-25 | 李华 | Medicine composition for treating membranous dysmenorrhea |
| CN104958691A (en) * | 2015-06-10 | 2015-10-07 | 张修斗 | Traditional Chinese medicinal composition for treating cold-damp stagnation type dysmenorrhoea, and preparation method thereof |
| CN110742940A (en) * | 2019-10-18 | 2020-02-04 | 河北旬沐生物科技有限公司 | Traditional Chinese medicine ointment capable of rapidly relieving pain and swelling and preparation method thereof |
-
2008
- 2008-05-04 CN CNA200810105824XA patent/CN101264314A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102205103A (en) * | 2011-05-13 | 2011-10-05 | 葛晓云 | Pure Chinese medicinal plaster for treating dysmenorrhea |
| CN102205103B (en) * | 2011-05-13 | 2012-09-12 | 吴玉平 | Pure Chinese medicinal plaster for treating dysmenorrhea |
| CN103316263A (en) * | 2013-07-03 | 2013-09-25 | 李华 | Medicine composition for treating membranous dysmenorrhea |
| CN104958691A (en) * | 2015-06-10 | 2015-10-07 | 张修斗 | Traditional Chinese medicinal composition for treating cold-damp stagnation type dysmenorrhoea, and preparation method thereof |
| CN110742940A (en) * | 2019-10-18 | 2020-02-04 | 河北旬沐生物科技有限公司 | Traditional Chinese medicine ointment capable of rapidly relieving pain and swelling and preparation method thereof |
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Open date: 20080917 |