CN101259205A - Medicaments assembly for treating adiposis and preparation thereof - Google Patents
Medicaments assembly for treating adiposis and preparation thereof Download PDFInfo
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- CN101259205A CN101259205A CNA2008101045216A CN200810104521A CN101259205A CN 101259205 A CN101259205 A CN 101259205A CN A2008101045216 A CNA2008101045216 A CN A2008101045216A CN 200810104521 A CN200810104521 A CN 200810104521A CN 101259205 A CN101259205 A CN 101259205A
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- YSIFYNVXJOGADM-KDYWOABDSA-N Shanzhiside Chemical compound O([C@H]1[C@H]2[C@@H](C(=CO1)C(O)=O)[C@H](O)C[C@@]2(O)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YSIFYNVXJOGADM-KDYWOABDSA-N 0.000 abstract 1
- PVPIPGMAEAJMTH-UHFFFAOYSA-N Shanzhiside Natural products OCC1OC(OC2OC=C(C3C(O)CC(O)C23)C(=O)O)C(O)C(O)C1O PVPIPGMAEAJMTH-UHFFFAOYSA-N 0.000 abstract 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine compound for curing adiposity and a preparation method thereof. The effective components of the present invention is formed by being extracted from drug ingredients of hemlock parsley, yanhusuo, coptis root, skullcap root, shanzhiside, rhubarb, officinal magnolia bark, banxia, liquorice, corktree bark, Tuckahoe, umbellate pore fungus, oriental waterplantain rhizome, largehead atractylode, lily and multiflower knotweed stem. The special medicinal active components of the present invention have the efficacy of stimulating blood circulation and dissolving stagnant, eliminating phlegm and softening hard masses. The present invention is applicable to adiposity patients with hypertension and hyperlipemia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of drug regimen that is used for the treatment of obesity and preparation method thereof.
Technical background
The fat origin cause of formation is complicated, and it is fat relevant with factors such as body constitution, age, dietary habit, work and rest, emotion, heredity that most scholars think.Chinese medicine is just on the books before more than 2000 years, as saying in " element is asked the logical deficiency and excess opinion of commenting ": " fertile high official, then the disease of Sorghum vulgare Pers. also "; " a Ling Shu Miraculous Pivot or Divine Axis disorder of defensive QI piece of writing " pointed out when touching upon the human body girth of a garment " people has fertilizer; cream is arranged, meat is arranged ", and " essence derived from food wins vigour; its people's fat and longevity not; vigour wins essence derived from food, and thin and longevity ", " of its people is the Sheng of plain officials report on the whole; bitter from there not being institute; as only to be that damp-phlegm is a lot of ", and the saying of " fertile people's excessive phlegm wets more, many deficiency of vital energys " are arranged again " fertile people's excessive phlegm and do not transport also through choke " later age.These argumentations are significant to the understanding and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of obesity to instructing us.
At first, fat relevant with people's natural endowment, on the whole this have genetic predisposition to match with the pointed primary disease of modern medicine, and investigating 14321 neonatal fat incidence rates according to Shenyang, Dalian, Beijing San Shi is 7.05%～16.6%.Attached Long March hospital of The 2nd Army Medical College is to 800 routine obese patients' etiological analysis, and wherein father and mother both sides or a side have the overweight people to reach 29.63%, and the overweight people accounts for 7.75% since the childhood, and these all illustrate fat relevant with heredity.
Secondly, relevant with surfeit delicious food, rich and fatty diet.Take in fineness and many, its part of having a surplus turns to cream fat, accumulate in the body, and then be " cream people ", " fat people ", " fertile people ".Obese patient carnivore in the family way, the hyperphagia of Tang Shi report 90% and Long March hospital investigation 13.75%.Long March hospital investigation obesity in puerperal accounts in the women obesity 38.02%, may will advance sweet food puerperal with folklore and attention " is confined in childbirth " relevant more.
Once more, lying on bed for a long time, sitting, Lack of Movement also are fat major reasons." element is asked and declared the healthy energy opinion " said: " excessive rest on bed impairing QI "; " Elementary Medicine " emphasizes that also the lying on bed for a long time sitting " hurts sb.'s feelings also " especially.Lying on bed for a long time, sitting, the deficiency of vital energy, the stagnation of QI must make fortuneization unable, defeated cloth imbalance, cream fat is cohesion, makes people's obesity.In addition, affection of exogenous damp accumulates in going into, and invasion and attack internal organs and internal damage by the excessive seven emotions influences function, and is also normal for the factor of obesity takes place.Among the internal organs with spleen, kidney, liver, gallbladder and fat in close relations.Deficiency of spleen-QI can not the normal metaplastic essence and blood, and defeated cloth is precise and tiny, the whole body of supplementing nutrition, and become cream fat phlegm-damp, and hold in skin, send out to fat.Deficiency of kidney-QI, normal promote the circulation of qi and water helps the strong fortune of spleen, and regulating fluid apssage and turbid damp is cohesion overflows to increase the weight of obesity in skin.Damaged by excess of seven emotions often causes irritability stasis, and it is smooth that suffocating of liver and gall is lost in transferring, and influences the strong fortune of spleen, and the lifting of mechanism of qi is transferred.And gallbladder can not normally be secreted semen deposition juice, clean turbidization fat, and then turbid fat is cohesion and fat.
Because the spleen deficiency of kidney-QI, the liver and gall imbalance not only causes cream fat expectorant turbid, and water is wet to stop holding, and it is smooth that mechanism of qi is lost, and sering is unfavorable, and the stagnation of QI can be arranged, or blood stasis.Therefore, existing deficiency syndrome of overweight people have the mark excess syndrome again, and deficiency in origin and excess in superficiality connects each other, and the while also deposits.In a word, sick position is based on spleen, and inferior and kidney and liver and gall also can reach cardiopulmonary, but always with the spleen deficiency of kidney-QI for seeing more, also as seen suffocating of liver and gall lacks of proper care.Clinical manifestation mostly is deficiency in origin and excess in superficiality, and deficiency in origin is based on the deficiency of vital energy, and mark is real turbid with expectorant, and cream fat is main, and the water of often holding concurrently is wet, also has the stagnation of QI concurrently, blood stasis.
The present invention is foundation with the theory of Chinese medical science, comes treatment of obesity by blood circulation promoting and blood stasis dispelling, the softening the hard mass that eliminates the phlegm, and raw material of the present invention is Chinese herbal medicine, has no side effect, and for making things convenient for the patient to take, the present invention has multiple dosage form simultaneously, is easy to carry and stores.
Summary of the invention:
One of purpose of the present invention provides a kind of drug regimen that is used for the treatment of obesity.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription
Rhizoma Chuanxiong 100-300 part Rhizoma Corydalis 100-300 part Rhizoma Coptidis 100-300 part
Radix Scutellariae 50-200 part SHANZHIZI 100-300 part Radix Et Rhizoma Rhei 50-200 part
Cortex Magnoliae Officinalis 50-200 part Rhizoma Pinelliae 50-200 part Radix Glycyrrhizae 50-200 part
Cortex Phellodendri 50-200 part Poria 50-200 part Polyporus 50-200 part
Rhizoma Alismatis 50-200 part Rhizoma Atractylodis Macrocephalae 50-200 part Bulbus Lilii 50-200 part
Caulis Polygoni Multiflori 50-200 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 portions of Rhizoma Coptidis of 150 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
100 parts of 150 parts of Radix Et Rhizoma Rhei of 100 parts of SHANZHIZI of Radix Scutellariae
100 parts in 100 portions of Radix Glycyrrhizaes of 100 parts of Rhizoma Pinelliaes of Cortex Magnoliae Officinalis
100 parts of 100 portions of Polyporus of 100 parts of Poria of Cortex Phellodendri
100 parts of 100 portions of Bulbus Liliies of 100 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Alismatis
100 parts of Caulis Polygoni Multiflori
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Rhizoma Corydalis adds 75% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Rhizoma Chuanxiongs, Rhizoma Coptidis, Radix Scutellariae, SHANZHIZI, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Radix Glycyrrhizae, Cortex Phellodendri, Poria, Polyporus, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Caulis Polygoni Multiflori add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has blood circulation promoting and blood stasis dispelling, the effect of the softening the hard mass that eliminates the phlegm.Be applicable to fat accompanied with hypertension hyperlipidemia person.
By the following examples technical scheme of the present invention is described further.
The specific embodiment
Embodiment 1: the preparation method of granule
1. write out a prescription
150 parts of 150 portions of Rhizoma Coptidis of 150 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
100 parts of 150 parts of Radix Et Rhizoma Rhei of 100 parts of SHANZHIZI of Radix Scutellariae
100 parts in 100 portions of Radix Glycyrrhizaes of 100 parts of Rhizoma Pinelliaes of Cortex Magnoliae Officinalis
100 parts of 100 portions of Polyporus of 100 parts of Poria of Cortex Phellodendri
100 parts of 100 portions of Bulbus Liliies of 100 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Alismatis
100 parts of Caulis Polygoni Multiflori
2. preparation technology
(1) Rhizoma Corydalis adds 75% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Rhizoma Chuanxiongs, Rhizoma Coptidis, Radix Scutellariae, SHANZHIZI, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Radix Glycyrrhizae, Cortex Phellodendri, Poria, Polyporus, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Caulis Polygoni Multiflori add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, add cane sugar powder, mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription
150 parts of 150 portions of Rhizoma Coptidis of 150 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
100 parts of 150 parts of Radix Et Rhizoma Rhei of 100 parts of SHANZHIZI of Radix Scutellariae
100 parts in 100 portions of Radix Glycyrrhizaes of 100 parts of Rhizoma Pinelliaes of Cortex Magnoliae Officinalis
100 parts of 100 portions of Polyporus of 100 parts of Poria of Cortex Phellodendri
100 parts of 100 portions of Bulbus Liliies of 100 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Alismatis
100 parts of Caulis Polygoni Multiflori
2. preparation technology
(1) Rhizoma Corydalis adds 75% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Rhizoma Chuanxiongs, Rhizoma Coptidis, Radix Scutellariae, SHANZHIZI, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Radix Glycyrrhizae, Cortex Phellodendri, Poria, Polyporus, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Caulis Polygoni Multiflori add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription
150 parts of 150 portions of Rhizoma Coptidis of 150 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
100 parts of 150 parts of Radix Et Rhizoma Rhei of 100 parts of SHANZHIZI of Radix Scutellariae
100 parts in 100 portions of Radix Glycyrrhizaes of 100 parts of Rhizoma Pinelliaes of Cortex Magnoliae Officinalis
100 parts of 100 portions of Polyporus of 100 parts of Poria of Cortex Phellodendri
100 parts of 100 portions of Bulbus Liliies of 100 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Alismatis
100 parts of Caulis Polygoni Multiflori
2. preparation technology
(1) Rhizoma Corydalis adds 75% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Rhizoma Chuanxiongs, Rhizoma Coptidis, Radix Scutellariae, SHANZHIZI, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Radix Glycyrrhizae, Cortex Phellodendri, Poria, Polyporus, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Caulis Polygoni Multiflori add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, pulverize, sieve, add starch, mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, a kind of drug regimen that is used for the treatment of obesity is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according.
Rhizoma Chuanxiong 100-300 part Rhizoma Corydalis 100-300 part Rhizoma Coptidis 100-300 part
Radix Scutellariae 50-200 part SHANZHIZI 100-300 part Radix Et Rhizoma Rhei 50-200 part
Cortex Magnoliae Officinalis 50-200 part Rhizoma Pinelliae 50-200 part Radix Glycyrrhizae 50-200 part
Cortex Phellodendri 50-200 part Poria 50-200 part Polyporus 50-200 part
Rhizoma Alismatis 50-200 part Rhizoma Atractylodis Macrocephalae 50-200 part Bulbus Lilii 50-200 part
Caulis Polygoni Multiflori 50-200 part
2, a kind of drug regimen that is used for the treatment of obesity according to claim 1 is characterized in that wherein preparing the preferred following raw materials according of described active ingredient.
150 parts of 150 portions of Rhizoma Coptidis of 150 parts of Rhizoma Corydalis of Rhizoma Chuanxiong
100 parts of 150 parts of Radix Et Rhizoma Rhei of 100 parts of SHANZHIZI of Radix Scutellariae
100 parts in 100 portions of Radix Glycyrrhizaes of 100 parts of Rhizoma Pinelliaes of Cortex Magnoliae Officinalis
100 parts of 100 portions of Polyporus of 100 parts of Poria of Cortex Phellodendri
100 parts of 100 portions of Bulbus Liliies of 100 parts of Rhizoma Atractylodis Macrocephalaes of Rhizoma Alismatis
100 parts of Caulis Polygoni Multiflori
3, according to the described a kind of drug regimen that is used for the treatment of obesity of claim 1-2, it is characterized in that adopting following method to make:
(1) Rhizoma Corydalis adds 75% alcohol dipping three times, floods 48 hours for the first time, and second and third time flooded respectively 24 hours, filters, and decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(2) medical materials such as all the other Rhizoma Chuanxiongs, Rhizoma Coptidis, Radix Scutellariae, SHANZHIZI, Radix Et Rhizoma Rhei, Cortex Magnoliae Officinalis, the Rhizoma Pinelliae, Radix Glycyrrhizae, Cortex Phellodendri, Poria, Polyporus, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Bulbus Lilii, Caulis Polygoni Multiflori add 10 times of decoctings and boil three times, 1 hour for the first time, second and third time 0.5 hour, filter, merging filtrate, filtrate is condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape, and vacuum drying below 85 ℃ becomes dried cream;
(3) step (1) get dry extract is got dry extract with step (2) mix, be ground into fine powder, add acceptable accessories and make different preparations such as granule, sheet, capsule.
4, according to any one described a kind of drug regimen that is used for the treatment of obesity among the claim 1-3, it is characterized in that this Chinese medicine composition is an oral formulations.
5, according to the described a kind of drug regimen that is used for the treatment of obesity of claim 3-4, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101045216A CN101259205A (en) | 2008-04-21 | 2008-04-21 | Medicaments assembly for treating adiposis and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101045216A CN101259205A (en) | 2008-04-21 | 2008-04-21 | Medicaments assembly for treating adiposis and preparation thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805826A (en) * | 2012-08-28 | 2012-12-05 | 韩非 | Drug for reducing weight and beautifying facial appearance and preparation method thereof |
| CN105695262A (en) * | 2016-03-15 | 2016-06-22 | 赵志平 | Beautifying wine |
| CN106822160A (en) * | 2017-02-16 | 2017-06-13 | 中国人民解放军第四军医大学 | Application of the Stibene-glucoside in the medicine and health products for preparing obesity-related hypertension |
-
2008
- 2008-04-21 CN CNA2008101045216A patent/CN101259205A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102805826A (en) * | 2012-08-28 | 2012-12-05 | 韩非 | Drug for reducing weight and beautifying facial appearance and preparation method thereof |
| CN105695262A (en) * | 2016-03-15 | 2016-06-22 | 赵志平 | Beautifying wine |
| CN106822160A (en) * | 2017-02-16 | 2017-06-13 | 中国人民解放军第四军医大学 | Application of the Stibene-glucoside in the medicine and health products for preparing obesity-related hypertension |
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Open date: 20080910 |