CN101243978A - Respiration sampling instrument and method of sampling respiration - Google Patents
Respiration sampling instrument and method of sampling respiration Download PDFInfo
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- CN101243978A CN101243978A CNA2008100246453A CN200810024645A CN101243978A CN 101243978 A CN101243978 A CN 101243978A CN A2008100246453 A CNA2008100246453 A CN A2008100246453A CN 200810024645 A CN200810024645 A CN 200810024645A CN 101243978 A CN101243978 A CN 101243978A
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- 238000005070 sampling Methods 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 21
- 230000029058 respiratory gaseous exchange Effects 0.000 title claims description 38
- 239000000523 sample Substances 0.000 claims abstract description 46
- 239000012071 phase Substances 0.000 claims abstract description 5
- 239000007790 solid phase Substances 0.000 claims abstract description 3
- 238000007689 inspection Methods 0.000 claims description 21
- 239000003463 adsorbent Substances 0.000 claims description 18
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 239000013076 target substance Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 6
- 238000009423 ventilation Methods 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 5
- 239000000376 reactant Substances 0.000 claims description 5
- 239000007791 liquid phase Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000007385 chemical modification Methods 0.000 claims description 3
- 239000002077 nanosphere Substances 0.000 claims description 3
- 230000001413 cellular effect Effects 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 claims description 2
- 206010011224 Cough Diseases 0.000 abstract description 8
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 238000007599 discharging Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009533 lab test Methods 0.000 abstract 1
- 238000007664 blowing Methods 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
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- 238000004451 qualitative analysis Methods 0.000 description 3
- 238000004445 quantitative analysis Methods 0.000 description 3
- 238000007445 Chromatographic isolation Methods 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
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- 229910052799 carbon Inorganic materials 0.000 description 2
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- 206010011409 Cross infection Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
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- 238000010521 absorption reaction Methods 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention relates to a breath sampling instrument and the method for sampling breath, belonging to technical field of medical appliances. The breath sampling instrument comprises a probe tube which is provided with a gas port and an air outlet. A mouth is arranged on the gas port of the probe tube and a first check valve and a second check valve are arranged in the airflow channel between the gas port and the air outlet. A test sample disconnecting and intercepting device is arranged between the first check valve and the second check valve. By using the breath sampling instrument, the airflow blown out can open the first check valve and then enter the airflow channel when the tester keeps the instrument in mouth to blow or cough, and the test sample disconnecting and intercepting device can separate and keep the fluid phase or the solid phase of the airflow blown out. The gas phase separated opens the second check valve before discharging and then the test sample disconnecting and intercepting device is put out for laboratory test. The invention cannot harm or upset the testee and also has the advantages of simple structure and convenient usage, so can be used for quickly diagnosing different diseases.
Description
Technical field
The present invention relates to a kind of diagnosis sampling apparatus, especially a kind of respiration sampling instrument also relates to the method for sampling that adopts this sampler simultaneously, belongs to the armarium technical field.
Background technology
At present, to chemically examine be the main method of diagnosis such as numerous diseases such as viral influenza to the blood sample that extracts the person under inspection.Though this hemodiagnosis method has stronger specific aim and higher accuracy, but because blood count leaves wound unavoidably, not only bring misery, also may cause cross infection, for dizzy mass formed by blood stasis person under inspection even can cause hardly imaginable serious consequence to the person under inspection.
In order to solve the problem that blood count exists, notification number is CN201029890, open day to disclose a kind of respiratory tract downtake spittle harvester for the Chinese patent application of 2008.03.05, this harvester is made up of housing, connecting rod, loam cake, bottom, collection film, offer cavity in the housing, housing upper end outer wall thread is connecting loam cake, the lower end outer wall thread is connecting bottom, and the intravital connecting rod of shell upper end is fixedly connected on loam cake inwall center, and the lower end is connecting the collection film by brace rod.It can insert person under inspection's throat, the spittle after the cough is sprayed on gathers on the film, directly takes out and is enclosed in censorship in the housing, the basic no pain of person under inspection.
Yet this harvester structure is still comparatively complicated, brings discomfort to the person under inspection unavoidably, and can only gather the sputum that cough produces, and it is still convenient inadequately not only to use, and restricted application.
Summary of the invention
The objective of the invention is to: at the defective of above prior art existence, propose a kind of simple in structure, easy to use, can gather the respiration sampling instrument of contained material to be checked in person under inspection's breath, provide the method for sampling respiration when using this respiration sampling instrument simultaneously.
In order to reach the above object: respiration sampling instrument of the present invention comprises a probe tube, described probe tube has exhalation vents and gas outlet, the exhalation vents of described probe tube is provided with a mouth, described probe tube is provided with from exhalation vents to the gas channel between the gas outlet and only allows air-flow to flow to first and second check valves of gas outlet from exhalation vents, sample is housed between described first and second check valves separates device for trapping.
It can be filtering adsorpting device that described sample separates device for trapping, for example the activated carbon filtration adsorbent equipment; Also can adopt the adsorbent of molecular sieve or micron ball, nanosphere and so on, or the adsorbent after adopting the adsorbent of gel and so on and adopting the process chemical modification, or the like.
Adopt the method for sampling respiration of above-mentioned respiration sampling instrument may further comprise the steps:
One, the person under inspection contains jet behind the mouth (comprise and blowing or cough);
Two, the air-flow that blows out enters gas channel after opening first check valve;
Three, sample separates device for trapping and separates and hold back liquid phase or solid phase target substance in the exhaled air flow;
Four, discharge after the isolating gas phase of process is opened second check valve;
Five, take out sample separation device for trapping and be used for chemical examination.
Beneficial effect of the present invention is as follows: be provided with two check valves that allow the exhalation air to pass through in the hollow probe tube of respiration sampling instrument of the present invention, when the gas that the person under inspection is breathed out can pass through this respiration sampling instrument smoothly, stop ambient atmos to enter, guaranteed sampling precision.Separation device for trapping between interior two check valves of probe tube can adsorb the target substance in person under inspection's breath, chemically examines after taking out, and can draw required medical diagnosis on disease result.Because this respiration sampling instrument and method of sampling respiration person under inspection only need contain the collection that mouth air blowing (or cough) can realize required sample, therefore can not cause any traumatic pain and sense of discomfort to the person under inspection, it is simple in structure, easy to use, the quick diagnosis of very suitable various diseases (especially respiratory tract disease).
It is that the opening pressure of described first check valve is less than second check valve that the present invention further improves.Like this, the gas channel between two check valves is formed greater than atmospheric hyperbar, thereby target substance (sample) can be more effectively gathered in condensing of the water in air vapour that helps breathing out.Certainly, also can not limit the opening pressure relation of first check valve and second check valve, take outside sampling tube, to add the telescopic measure of condensation and improve collecting efficiency.
The present invention further improves, also contain suction nozzle, described suction nozzle has air entry and air inlet, the air entry of described probe tube is communicated with described mouth, described suction nozzle is provided with from air entry to the air intake passage between the air inlet and only allows air-flow to flow to third and fourth check valve of air entry from air inlet, between described third and fourth check valve ventilation mixing arrangement is housed.Like this, medicine or the reactant that helps to chemically examine can be added in the ventilation mixing arrangement, the person under inspection sucks the air that contains medicine or reactant by suction nozzle earlier after containing mouth, jet again exhalation, and the sample of Cai Jiing will more help follow-up chemical examination like this.
Description of drawings
The present invention is further illustrated below in conjunction with accompanying drawing.
Fig. 1 is the structural representation of the embodiment of the invention one.
Fig. 2 is the structural representation of the embodiment of the invention two.
Fig. 3 is the structural representation of the embodiment of the invention three.
The specific embodiment
Embodiment one
The respiration sampling instrument of present embodiment comprises a L shaped probe tube 1 as shown in Figure 1, and an end of this probe tube is an exhalation vents 11, and the other end is gas outlet 12.The exhalation vents 12 of probe tube 1 is with a mouth 2 that is used for person under inspection's air blowing (or cough), has two diaphragm type one-way valves 3 and 4 that only allow the exhalation air to be entered, discharged by gas outlet 12 by exhalation vents 11 in the probe tube 11.Wherein, the diaphragm elasticity of check valve 4 is greater than check valve, so opening pressure is bigger, thereby after can working as person under inspection's expiration, forms greater than atmospheric suitable high pressure in the gas channel between two check valves.
Be equipped with the activated carbon adsorbent 5 that is distributed in the stratiform filter between probe tube 1 interior two check valves 3,4 and constitute samples and separate device for trapping, can adsorb material to be checked in person under inspection's breath by adsorbent.Except that active carbon, adsorbent can have multiple choices.
During use, the person under inspection contains jet behind the mouth (comprise and blowing or cough), enters gas channel after the air-flow open check valve 3 that blows out.Sample separates active carbon in the device for trapping and separates and hold back liquid phase target substance liquid phase in the exhaled air flow, discharges through isolating gas phase open check valve 4 backs.Afterwards adsorbent is taken out from probe tube, modes such as employing extraction extract target substance from activated carbon.In case of necessity, can concentrate further chromatographic isolation of back, will separate sample after purifying with the analytical method of mass spectrum, infrared, nuclear magnetic resonance, NMR and so in addition separation detection and qualitative and quantitative analysis.
Embodiment two
The present embodiment respiration sampling instrument mainly contains with embodiment one difference as shown in Figure 2: probe tube 1 is straight tube, and mouth 2 is for having L type folding pipe.The advantage that adopts straight tube structure is the adsorbent of being convenient in the take-off pipe, and transportation and preserve all comparatively convenient.In addition, separation device for trapping 5 cross sections in the probe tube are cellular, can make adsorbent wherein have bigger specific surface area like this, help the absorption collection of target substance.The material that separates device for trapping 5 surface adsorption micron balls, nanosphere and so on is as adsorbent.
Therefore the detachable packing of the respiration sampling instrument of present embodiment also is furnished with two seal covers that are used to be enclosed within on probe tube exhalation vents, the gas outlet.Before the use, seal cover is enclosed within on probe tube exhalation vents, the gas outlet; During use, seal cover is taken off, then mouth is connected inserting with exhalation vents, the person under inspection begins facing to mouth air blowing (or cough) then.After finishing using, take off mouth, seal cover is enclosed within respectively on the exhalation vents, gas outlet of probe tube.Can effectively intercept like this in the air admission pipe extraneous under non-working condition, guarantee that sampling is not disturbed by extrinsic factor.
Sampling step is with reference to embodiment one, and after adsorbent was taken out from probe tube, the mode that adopts extraction or chromatographic isolation extracts target substance from adsorbent carried out separation detection and qualitative and quantitative analysis gets final product.
Embodiment three
The present embodiment respiration sampling instrument as shown in Figure 3, different with embodiment two is, mouth 2 essence are a threeway, its upper port is as embodiment two, the plug-in mounting sampling tube, lower port is plug-in mounting one suction nozzle then, this suction nozzle has air entry 6 and air inlet 8, air entry 6 is communicated with mouth 2, suction nozzle is provided with two check valves 9 and 10 that only allow air-flow to flow to air entry from air inlet from air entry 6 to the air intake passage between the air inlet 8, ventilation mixing arrangement 7 is housed between two check valves, and this device can be used to be loaded with medicine or the reactant that helps chemically examine.During use, the person under inspection sucks the air that contains medicine or reactant by suction nozzle earlier after containing mouth, jet again exhalation, and the sample of Cai Jiing will more help follow-up chemical examination like this.
In addition, separation device for trapping in the sampling tube 5 is made of helical duct, and therefore surface attachment can fully separate the target substance of holding back in the expiration through the adsorbent after the chemical modification.After the sampling, adsorbent is taken out from probe tube, adopt corresponding chemical reaction, target substance can be extracted from product, carry out necessary detection and qualitative and quantitative analysis again.
The equal indefiniteness of above embodiment.In addition to the implementation, the present invention can also have other embodiments.For example, thus the shape of mouth can be designed to different shape such as greatly be convenient to contain such as port as required; Mouth and sampling tube can be an integral body; Respiration sampling instrument integral body can be straight tube structure; The structure of separating device for trapping can have other combination and variation, can adopt membranaceous or the lamellar gel adsorber; Or the like.All employings are equal to the technical scheme of replacement or equivalent transformation form, all drop on the protection domain of requirement of the present invention.
Claims (10)
1, a kind of respiration sampling instrument, comprise a probe tube, described probe tube has exhalation vents and gas outlet, it is characterized in that: the exhalation vents of described probe tube is provided with a mouth, described probe tube is provided with from exhalation vents to the gas channel between the gas outlet and only allows air-flow to flow to first and second check valves of gas outlet from exhalation vents, sample is housed between described first and second check valves separates device for trapping.
2, respiration sampling instrument according to claim 1 and method of sampling respiration is characterized in that: the opening pressure of described first check valve is less than second check valve.
3, respiration sampling instrument according to claim 1 and 2 and method of sampling respiration, it is characterized in that: also contain suction nozzle, described suction nozzle has air entry and air inlet, the air entry of described probe tube is communicated with described mouth, described suction nozzle is provided with from air entry to the air intake passage between the air inlet and only allows air-flow to flow to third and fourth check valve of air entry from air inlet, between described third and fourth check valve ventilation mixing arrangement is housed.
4, respiration sampling instrument according to claim 3 and method of sampling respiration is characterized in that: described separation device for trapping is made of the activated carbon adsorbent that is distributed in the stratiform filter.
5, respiration sampling instrument according to claim 3 and method of sampling respiration is characterized in that: the cross section of described separation device for trapping is cellular, surface adsorption micron ball or nanosphere adsorbent.
6, respiration sampling instrument according to claim 3 and method of sampling respiration is characterized in that: described separation device for trapping is made of helical duct, and surface attachment is through the adsorbent after the chemical modification.
7, respiration sampling instrument according to claim 3 and method of sampling respiration is characterized in that: also be furnished with two seal covers that are used to be enclosed within on probe tube exhalation vents, the gas outlet.
8,, it is characterized in that may further comprise the steps according to the method for sampling respiration of the described respiration sampling instrument of claim 1:
One, the person under inspection contains behind the mouth jet;
Two, the air-flow that blows out enters gas channel after opening first check valve;
Three, sample separates device for trapping and separates and hold back liquid phase or solid phase target substance in the exhaled air flow;
Four, discharge after the isolating gas phase of process is opened second check valve;
Five, take out sample separation device for trapping and be used for chemical examination.
9, method of sampling respiration according to claim 8 is characterized in that: the opening pressure of described first check valve is less than second check valve; The gas channel of the air-flow that blows out in the described step 2 between first and second check valves forms hyperbar.
10, method of sampling respiration according to claim 9, it is characterized in that: also contain suction nozzle, described suction nozzle has air entry and air inlet, the air entry of described probe tube is communicated with described mouth, described suction nozzle is provided with from air entry to the air intake passage between the air inlet and only allows air-flow to flow to third and fourth check valve of air entry from air inlet, and the ventilation mixing arrangement that contains medicine or reactant is housed between described third and fourth check valve; Described step 1 person under inspection contain behind the mouth jet before, suck air by suction nozzle earlier through the ventilation mixing arrangement.
Priority Applications (1)
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CN2008100246453A CN101243978B (en) | 2008-03-31 | 2008-03-31 | Respiration sampling instrument and method of sampling respiration |
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CN2008100246453A CN101243978B (en) | 2008-03-31 | 2008-03-31 | Respiration sampling instrument and method of sampling respiration |
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CN101243978A true CN101243978A (en) | 2008-08-20 |
CN101243978B CN101243978B (en) | 2010-08-11 |
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CN2008100246453A Expired - Fee Related CN101243978B (en) | 2008-03-31 | 2008-03-31 | Respiration sampling instrument and method of sampling respiration |
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Cited By (14)
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CN102353564A (en) * | 2011-06-16 | 2012-02-15 | 深圳国技仪器有限公司 | Individual sampler |
CN103237493A (en) * | 2010-12-08 | 2013-08-07 | 艾罗克林有限公司 | Apparatus and method for the collection of samples of exhaled air |
CN104257384A (en) * | 2014-09-29 | 2015-01-07 | 无锡市尚沃医疗电子股份有限公司 | Handheld suction and filtration device |
CN104840224A (en) * | 2015-05-29 | 2015-08-19 | 齐天杰 | Respiratory tract lower airway droplet collector |
CN105726069A (en) * | 2016-04-15 | 2016-07-06 | 福州艾维德生物医药有限公司 | Expiratory air condensed liquid collecting device |
CN105928747A (en) * | 2016-07-04 | 2016-09-07 | 无锡信大气象传感网科技有限公司 | Splitting type air particle collection device |
CN106680041A (en) * | 2017-02-23 | 2017-05-17 | 四川大学 | Expired air collection device |
CN107036852A (en) * | 2016-02-03 | 2017-08-11 | 奎特龙设备有限公司 | Breath tester device |
CN107115112A (en) * | 2016-02-24 | 2017-09-01 | 兰州大学第医院 | It is a kind of can the air-breathing of Quantitative Monitoring, expiration functional training device |
CN108348192A (en) * | 2015-11-24 | 2018-07-31 | 蒙克普拉斯特股份公司 | Portable sampling equipment, holder and method for collecting the particle from expiratory air |
CN111044547A (en) * | 2019-12-31 | 2020-04-21 | 深圳市福瑞康科技有限公司 | Absorber, gas collecting card, respiration detection equipment, preparation method and application |
CN111419291A (en) * | 2020-04-24 | 2020-07-17 | 陈粉 | Medical self-service sampling device of respiratory track |
CN111803137A (en) * | 2020-08-06 | 2020-10-23 | 厦门市云鹏科技发展有限公司 | Disposable air blowing new coronavirus collector and collection method thereof |
CN116211282A (en) * | 2023-02-24 | 2023-06-06 | 南京诺源医疗器械有限公司 | Medical sampler |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5081871A (en) * | 1989-02-02 | 1992-01-21 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Breath sampler |
ES2120903B1 (en) * | 1996-11-12 | 1999-05-16 | Isomed S L | METHOD AND KIT FOR THE DETECTION OF HELICOBACTER PYLORI. |
-
2008
- 2008-03-31 CN CN2008100246453A patent/CN101243978B/en not_active Expired - Fee Related
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CN102353564A (en) * | 2011-06-16 | 2012-02-15 | 深圳国技仪器有限公司 | Individual sampler |
CN104257384A (en) * | 2014-09-29 | 2015-01-07 | 无锡市尚沃医疗电子股份有限公司 | Handheld suction and filtration device |
CN104840224B (en) * | 2015-05-29 | 2018-05-01 | 齐天杰 | A kind of respiratory tract lower air passage droplet collector |
CN104840224A (en) * | 2015-05-29 | 2015-08-19 | 齐天杰 | Respiratory tract lower airway droplet collector |
CN108348192A (en) * | 2015-11-24 | 2018-07-31 | 蒙克普拉斯特股份公司 | Portable sampling equipment, holder and method for collecting the particle from expiratory air |
CN108348192B (en) * | 2015-11-24 | 2022-03-01 | 蒙克普拉斯特股份公司 | Portable sampling device, holder and method for collecting particles from exhaled breath |
CN107036852A (en) * | 2016-02-03 | 2017-08-11 | 奎特龙设备有限公司 | Breath tester device |
CN107036852B (en) * | 2016-02-03 | 2022-03-08 | 奎特龙设备有限公司 | Expiration testing device |
CN107115112B (en) * | 2016-02-24 | 2023-04-14 | 兰州大学第一医院 | An inhalation and exhalation function training device capable of quantitative monitoring |
CN107115112A (en) * | 2016-02-24 | 2017-09-01 | 兰州大学第医院 | It is a kind of can the air-breathing of Quantitative Monitoring, expiration functional training device |
CN105726069B (en) * | 2016-04-15 | 2018-03-30 | 福州艾维德生物医药有限公司 | Breathe-out air condensate gathering-device |
CN105726069A (en) * | 2016-04-15 | 2016-07-06 | 福州艾维德生物医药有限公司 | Expiratory air condensed liquid collecting device |
CN105928747A (en) * | 2016-07-04 | 2016-09-07 | 无锡信大气象传感网科技有限公司 | Splitting type air particle collection device |
CN105928747B (en) * | 2016-07-04 | 2018-07-06 | 无锡信大气象传感网科技有限公司 | A kind of Split type air particle matter collection device |
CN106680041A (en) * | 2017-02-23 | 2017-05-17 | 四川大学 | Expired air collection device |
CN111044547A (en) * | 2019-12-31 | 2020-04-21 | 深圳市福瑞康科技有限公司 | Absorber, gas collecting card, respiration detection equipment, preparation method and application |
CN111419291A (en) * | 2020-04-24 | 2020-07-17 | 陈粉 | Medical self-service sampling device of respiratory track |
CN111803137A (en) * | 2020-08-06 | 2020-10-23 | 厦门市云鹏科技发展有限公司 | Disposable air blowing new coronavirus collector and collection method thereof |
CN116211282A (en) * | 2023-02-24 | 2023-06-06 | 南京诺源医疗器械有限公司 | Medical sampler |
CN116211282B (en) * | 2023-02-24 | 2024-01-02 | 南京诺源医疗器械有限公司 | Medical sampler |
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