CN101229587A - Bioceramic titanium-based composite material and preparation method thereof - Google Patents

Abstract

The invention relate to a method for preparing powder metallurgy of bioceramic titanium matrix composite material, which is characterized in that: (1) metal titanium powder with granularity of 5Mum-100Mum and nano-sized hydroxyapatite powder with the granularity less than 100nm are mixed uniformly, wherein, volume fraction of the nano-sized hydroxyapatite powder is 1 percent to 10 percent; (2) the mixing powder is shaped by using isostatic pressing and is vacuum sintered under 1050 DEG C to 1200 DEG C to prepare the bioceramic titanium matrix composite material. bioactivity of the prepared composite material is higher than that of pure titanium material prepared by a powder metallurgy method; bending strength of the composite material is larger than 140MPa, which is higher than or equal to that of human bones; compressive elastic modulus of the composite material is 7.9GPa to18.5GPa, which is close to that of the human bones. The invention can be used for preparing biological replacement (restoration) bodies which are used by hard tissues such as human skeletons, teeth, and so on.

Description

Bioceramic titanium-based composite material and preparation method thereof

technical field

The invention relates to a biomedical metal-based composite material, in particular to a bioceramic titanium-based composite material and a preparation method thereof.

Background technique

At present, most of the replacement (repair) materials for biological hard tissues such as human bones and teeth are rolled or cast titanium materials. Titanium materials have the characteristics of corrosion resistance, high strength and biocompatibility. However, the elastic modulus of rolled or cast titanium materials is significantly higher than that of human bone, thus reducing the biomechanical compatibility of materials and limiting the application of titanium materials. The titanium material prepared by the powder metallurgy method has an appropriate amount of pores, which reduces the elastic modulus of the material and improves the biomechanical compatibility of the material. However, the biological activity of titanium materials prepared by powder metallurgy methods is lacking, and the biomechanical compatibility of materials needs to be improved.

Contents of the invention

The purpose of the present invention is to provide a powder metallurgy preparation method for bioceramic titanium-based composite materials, which solves the problems of lack of biological activity of titanium materials and high elastic modulus of materials in the prior art.

The object of the present invention is also to provide the bioceramic titanium-based composite material prepared by the method.

The preparation method of the bioceramic titanium-based composite material of the present invention comprises the following steps:

(1) Mix uniformly the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder with a particle size less than 100 nm, wherein the volume fraction of the nano-hydroxyapatite is 1% to 10%, preferably 1 to 9%, further Preferably 2-4.9%;

(2) The mixed powder is formed by isostatic pressing, and then vacuum sintered at a sintering temperature of 1050°C to 1200°C.

The design basis and main features of the bioceramic titanium-based composite material and its preparation method of the present invention are as follows: after the titanium powder is added with nano-hydroxyapatite powder with biological activity, the biological activity of the composite material prepared by powder metallurgy is improved, and the biological activity of the composite material is high. Pure titanium material prepared by powder metallurgy; adding nano-hydroxyapatite powder to titanium powder increases the porosity of the composite material prepared by powder metallurgy, further reduces the elastic modulus of the composite material, and the compressive elastic modulus of the composite material is 7.9GPa ~18.5GPa, which is close to human bone; after titanium powder is added with nano-hydroxyapatite powder, the porosity of the composite material prepared by powder metallurgy increases, which makes the strength of the composite material decrease, but the bending strength of the composite material is greater than 140MPa, still Higher than or equivalent to human bone. Bioceramic titanium-based composite materials can be used to prepare biological replacement (restoration) bodies for hard tissues such as human bones and teeth.

Detailed ways

Embodiment 1: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder (the volume fraction of nano-hydroxyapatite powder added is 10%) with a particle size less than 100 nm, and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1100° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 154MPa, and the compressive elastic modulus is 9.3GPa.

Embodiment 2: the titanium metal powder with a particle size of 5 μm to 100 μm is mixed evenly with nano-hydroxyapatite powder (the volume fraction of nano-hydroxyapatite powder added is 2%) with a particle size less than 100 nm, and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1100° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 860MPa, and the compressive elastic modulus is 17GPa.

Embodiment 3: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder with a particle size less than 100 nm (the volume fraction of nano-hydroxyapatite powder added is 4.9%), and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1150° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 435MPa, and the compressive elastic modulus is 14GPa.

Embodiment 4: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder with a particle size less than 100 nm (the volume fraction of nano-hydroxyapatite powder added is 10%), and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1050° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 144MPa, and the compressive elastic modulus is 7.9GPa.

Embodiment 5: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder (nano-hydroxyapatite powder addition volume fraction 9%) with a particle size less than 100 nm, and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1100° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 170MPa, and the compressive elastic modulus is 9.8GPa.

Embodiment 6: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder with a particle size less than 100 nm (the volume fraction of nano-hydroxyapatite powder added is 1%), and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1200° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 950MPa, and the compressive elastic modulus is 18.5GPa.

Example 7: Mix the titanium metal powder with a particle size of 5 μm to 100 μm and the nano-hydroxyapatite powder with a particle size less than 100 nm (the volume fraction of nano-hydroxyapatite powder added is 3%), and the mixed powder is formed by isostatic pressing. Then vacuum sintering at 1200° C. to prepare a bioceramic titanium-based composite material. The biological activity of the composite material is higher than that of the pure titanium material prepared by powder metallurgy method, the bending strength of the composite material is 720MPa, and the compressive elastic modulus is 16GPa.

Claims (4)

1. A powder metallurgy preparation method of bioceramic titanium-based composite material, characterized in that it comprises the steps: (1) uniformly mixing metal titanium powder with a particle size of 5 μm to 100 μm and nano-hydroxyapatite powder with a particle size of less than 100 nm, wherein the volume fraction of nano-hydroxyapatite is 1% to 10%; (2) The mixed powder is formed by isostatic pressing, and then vacuum sintered at a sintering temperature of 1050°C to 1200°C. 2. The method according to claim 1, characterized in that the volume fraction of the nano-hydroxyapatite is 1% to 9%. 3. The method according to claim 2, characterized in that the volume fraction of the nano-hydroxyapatite is 2%-4.9%. 4. The bioceramic titanium-based composite material prepared by the method according to any one of claims 1 to 3.