CN101219069A - Double-layer composite bracket for renovating cartilage - Google Patents
Double-layer composite bracket for renovating cartilage Download PDFInfo
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- CN101219069A CN101219069A CNA2008100521713A CN200810052171A CN101219069A CN 101219069 A CN101219069 A CN 101219069A CN A2008100521713 A CNA2008100521713 A CN A2008100521713A CN 200810052171 A CN200810052171 A CN 200810052171A CN 101219069 A CN101219069 A CN 101219069A
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- polyglycolic acid
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- 210000000845 cartilage Anatomy 0.000 title claims abstract description 63
- 239000002131 composite material Substances 0.000 title abstract 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 27
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 26
- 102000008186 Collagen Human genes 0.000 claims abstract description 15
- 108010035532 Collagen Proteins 0.000 claims abstract description 15
- 229920001436 collagen Polymers 0.000 claims abstract description 15
- 229920002101 Chitin Polymers 0.000 claims abstract description 10
- 229920000954 Polyglycolide Polymers 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 10
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 10
- 239000004633 polyglycolic acid Substances 0.000 claims abstract description 10
- 239000004626 polylactic acid Substances 0.000 claims abstract description 10
- 229940117828 polylactic acid-polyglycolic acid copolymer Drugs 0.000 claims abstract description 10
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 5
- 102000009123 Fibrin Human genes 0.000 claims abstract description 5
- 108010073385 Fibrin Proteins 0.000 claims abstract description 5
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229940072056 alginate Drugs 0.000 claims abstract description 5
- 229920000615 alginic acid Polymers 0.000 claims abstract description 5
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 5
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 5
- 229950003499 fibrin Drugs 0.000 claims abstract description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 5
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 5
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 5
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 5
- 229960005188 collagen Drugs 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims description 36
- 238000004088 simulation Methods 0.000 claims description 36
- 210000005065 subchondral bone plate Anatomy 0.000 claims description 25
- 210000000988 bone and bone Anatomy 0.000 claims description 24
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 10
- 108010022355 Fibroins Proteins 0.000 claims description 8
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 4
- 229920002530 polyetherether ketone Polymers 0.000 claims description 4
- 210000001519 tissue Anatomy 0.000 abstract description 9
- 230000000877 morphologic effect Effects 0.000 abstract description 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 229920001661 Chitosan Polymers 0.000 description 32
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000008014 freezing Effects 0.000 description 6
- 238000007710 freezing Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 210000004271 bone marrow stromal cell Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011010 flushing procedure Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010007710 Cartilage injury Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The invention discloses a bilayer composite frame applied to osteochondral repair. The frame is composed of cylinder bed frame with one end as a simulated cartilage sample layer and the other end as a simulated cartilage sending down fishbone layer, the two layers combine closely and the outer surface of the simulated cartilage sending down fishbone layer is provided with threads. The simulated cartilage sample layer adopts one or a plurality of mixtures of chitin, chitin collagen, fibrin, alginate, silk protein, polylactic acid, polyglycolic acid, polylactic acid-polyglycolic acid copolymer and the simulated cartilage sending down fishbone layer adopts one or a plurality of mixtures of hydroxyapatite, tricalcium phosphate, peek, polylactic acid-polyglycolic acid copolymer, polyglycolic acid, polylactic acid and silk protein. The simulated cartilage sample layer is 1-5mm in thickness with a porosity of 70-90 percent and an aperture of 200-400 Mum and the simulated cartilage sending down fishbone layer is 2-20mm in thickness with a porosity of 50-75 percent and an aperture of 200-500 Mum. The physicochemical properties and morphological characteristics of the composite frame of the invention meet the requirements of osteochondral tissue engineering.
Description
Technical field
The present invention relates to a kind of supporting structure that is used for the osteochondral tissue engineering, relate in particular to a kind of compound rest structure that is used for the bone repair of cartilage.
Background technology
Studies show that subchondral bone is significant in cartilage injury's reparation, it plays a part to support, adhere to or even nutrition to cartilage.Subchondral bone damage can influence the metabolism of cartilage on it, brings out osteoarthritis and cartilage degeneration easily, and the long-term effect of repair of cartilage is had material impact.There are some researches show that the regression of subchondral bone is early than cartilage degeneration.The simple cartilage of repairing may obtain curative effect in a short time, but its long-term effect is not good enough, the regression again of the cartilage of reparation.Simple organization engineered cartilage or autotransplantation cartilage can not solve this type of problem well.
Summary of the invention
To repair the used support long-term effect of cartilage merely not good enough in order to overcome prior art, the technical problem of regression again appears in the cartilage of repairing, and the invention provides the two-layer compound support that is used for the bone repair of cartilage that a kind of physicochemical property and morphological characteristic all meet the osteochondral tissue engineering.
In order to solve the problems of the technologies described above, the present invention is used for the technical scheme that the two-layer compound support of bone repair of cartilage is achieved: be made of pedestal, the overall shape of described pedestal is a cylinder, the diameter of described pedestal is 4～12mm, one end of described cylinder pedestal is simulation cartilage sample layer, its other end is simulation subchondral bone layer, and described two-layer combining closely is positioned at described simulation subchondral bone layer outer surface and is provided with screw thread.
Another technical scheme that the present invention is used for the two-layer compound support of bone repair of cartilage is: be made of pedestal, the overall shape of described pedestal is a wedge type, the big end of described wedge type pedestal is simulation cartilage sample layer, its other end is simulation subchondral bone layer, described two-layer combining closely, the cross section of described wedge type is square or approximate positive square, and the cornerwise length in its cross section is 4～12mm.
The present invention is used for the two-layer compound support of bone repair of cartilage, and wherein, the material of described simulation cartilage sample layer adopts chitin, chitin collagen, fibrin, alginate, fibroin, polylactic acid, polyglycolic acid, the mixture of one or more in polylactic acid-polyglycolic acid copolymer; The material of described simulation subchondral bone layer adopts hydroxyapatite, tricalcium phosphate, polyether-ether-ketone, polylactic acid-polyglycolic acid copolymer, polyglycolic acid, polylactic acid, the mixture of one or more in the fibroin.The thickness of described simulation cartilage sample layer is 1～5mm, and the porosity of this layer is 70～90%, and its aperture is 200～400 μ m; The thickness of described simulation subchondral bone layer is 2～20mm, and the porosity of this layer is 50～75%, and its aperture is 200～500 μ m.
Compared with prior art, the beneficial effect that the present invention had is: because each layer in the two-layer compound support of the present invention can be simulated cartilage sample layer and subchondral bone layer respectively, in repairing the bone cartilage, use two-layer compound support of the present invention, cell, tissue intersolubility are good, the hole interlinking is good, and the compound rest physicochemical property meets the requirement of osteochondral tissue engineering rack; Because support adopts cylinder, round platform or wedge type, and be provided with screw thread at simulation subchondral bone layer, operation is convenient in its morphological characteristic.
Description of drawings
Fig. 1 is the structural representation that the present invention is used for the two-layer compound support of bone repair of cartilage;
Fig. 2 is the structure enlarged diagram of the cartilage of simulation shown in Fig. 1 sample layer 1;
Fig. 3 is the structure enlarged diagram of the subchondral bone of simulation shown in Fig. 1 layer 2.
The specific embodiment
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
As shown in Figure 1, the two-layer compound support that the present invention is used for the bone repair of cartilage is made of pedestal, and the overall shape of described pedestal is a cylinder, and its diameter is 4～12mm.One end of described cylinder pedestal is simulation subchondral bone layer 2 for simulation cartilage sample layer 1, its other end, described two-layer combining closely, and in order to be convenient to operation in using, the outer surface that is positioned at simulation subchondral bone layer 2 is provided with screw thread.
Another technical scheme that is achieved that the present invention is used for the two-layer compound support of bone repair of cartilage is that described pedestal is designed to wedge type, the big end of described wedge type pedestal is simulation cartilage sample layer, its other end is simulation subchondral bone layer, described two-layer combining closely, the cross section of this wedge type is a square, also can be proximate positive square, the catercorner length of its square sectional be 4～12mm.
The present invention is used for the cartilage of simulation described in the two-layer compound support of bone repair of cartilage sample layer material can adopt chitin (chitosan), chitin collagen (chitosan collagen), fibrin, alginate, fibroin, polylactic acid, polyglycolic acid, the mixture of one or more in polylactic acid-polyglycolic acid copolymer (PLGA); The thickness of described simulation cartilage sample layer is 1～5mm, and the porosity of this layer is 70～90%, and its aperture is 200～400 μ m.Described subchondral bone layer material can adopt hydroxyapatite, tricalcium phosphate, polyether-ether-ketone, polylactic acid-polyglycolic acid copolymer (PLGA), polyglycolic acid, polylactic acid, the mixture of one or more in the fibroin; The thickness of described simulation subchondral bone layer is 2～20mm, and the porosity of this layer is 50～75%, and its aperture is 200～500 μ m.
Two specific embodiments that the present invention is used for the two-layer compound support of bone repair of cartilage are described respectively below.
Embodiment one: chitosan collagen/PEEK-HA two-layer compound support
Double shells polysaccharide collagen/polyether-ether-ketone-hydroxyapatite (PEEK-HA) two-layer compound support analog bone cartilage spline structure on the organizational structure, chitosan collagen layer simulation cartilage sample layer, PEEK-HA layer simulation subchondral bone layer, plan is in conjunction with mesenchymal stem cells MSCs, repair the bone cartilage of regression simultaneously, thereby from long-range solution cartilage defect or regression.Because chitosan, collagen, HA are natural biologic materials, cell, tissue intersolubility are good.Wherein, as shown in Figures 2 and 3, the porosity of CS layer (%) is designed to: 76 ± 5.01, and the porosity of HA layer (%) is designed to 72 ± 4.23; CS layer pore size 200～400 μ m, average out to 300 μ m; HA layer pore size is 200～500 μ m, average out to 350 μ m, and the hole interlinking is good, and the compound rest physicochemical property meets the requirement of osteochondral tissue engineering rack.
The manufacture method of above-mentioned chitosan collagen/PEEK-HA two-layer compound support is unrestricted, wherein: HA layer segment support can adopt laser sintered method to make, adopt rapid freezing method of the prior art to make this two-layer compound support on this basis, its manufacturing process is as follows: (1) takes by weighing chitosan collagen and is dissolved in that to be made into concentration in the acetic acid be 3% (w/v) chitosan gum original solution, add a certain amount of Polyethylene Glycol simultaneously, centrifugal removal bubble.(2) physical and chemical parameter of PEEK-HA layer support is imported computer, such as: the porosity of PEEK-HA layer (%) is 72 ± 4.23, and the aperture is 200～500 μ m, and its meansigma methods is 350 μ m, require parameters such as the hole interlinking is good, utilize laser sintered legal system to make PEEK-HA layer segment support.(3) HA layer segment support is put into mould, get the chitosan gum original solution for preparing, pour in the mould, allow the chitosan gum original solution rest on HA layer segment support at least 1 minute, it is freezing to put into refrigerator, drain lyophilizing in the machine freezing, make chitosan collagen/PEEK-HA compound rest, freeze dried chitosan collagen/PEEK-HA compound rest put into NaOH, in and support in acetum, PBS liquid flushing repeatedly is to pH value neutrality.By above-mentioned steps chitosan collagen/PEEK-HA two-layer compound support is performed.
Embodiment two: CS/HA two-layer compound support
Chitosan (CS)/hydroxyapatite (HA) two-layer compound support analog bone cartilage spline structure on the organizational structure, that is: the CS layer is simulated cartilage sample layer, HA layer simulation subchondral bone layer, plan is in conjunction with mesenchymal stem cells MSCs, repair the bone cartilage of regression simultaneously, thereby from long-range solution cartilage defect or regression.Because CS, HA be natural biologic material, cell, tissue intersolubility are good; As shown in Figures 2 and 3, the porosity of CS layer (%) is designed in this compound rest: 76 ± 5.01, and the porosity of HA layer (%) is designed to 72 ± 4.23; CS layer pore size is 200～400 μ m, and average out to 300 μ m, HA layer pore size are 200～500 μ m, average out to 350 μ m, and its hole interlinking is good, and the compound rest physicochemical property meets the requirement of osteochondral tissue engineering rack.
The manufacture method of above-mentioned CS/HA two-layer compound support is unrestricted, for example can adopt rapid freezing method of the prior art, its manufacturing process is as follows: (1) takes by weighing chitosan and is dissolved in that to be made into concentration in the acetic acid be 3% (w/v) chitosan solution, add a certain amount of Polyethylene Glycol simultaneously, centrifugal removal bubble.(2) be that the HA layer segment support of 2～10mm is put into the support mould with set thickness, get the chitosan solution for preparing, pour in this mould, allow chitosan solution rest on HA layer segment support at least 1 minute, it is freezing to put into refrigerator, drain lyophilizing in the machine freezing, make chitosan (CS)/hydroxyapatite (HA) support, freeze dried chitosan (CS)/hydroxyapatite (HA) support is put into N
aAmong the OH, in and the acetum in the support, repeatedly with the flushing of PBS liquid, to pH value neutrality.Can make CS/HA two-layer compound support by above-mentioned steps.
Although in conjunction with the accompanying drawings the present invention has been carried out foregoing description; but the present invention is not limited to the above-mentioned specific embodiment; the above-mentioned specific embodiment only is schematic; rather than it is restrictive; those of ordinary skill in the art is under enlightenment of the present invention; under the situation that does not break away from aim of the present invention, can also make a lot of distortion, these all belong to the row of protection of the present invention.
Claims (8)
1. two-layer compound support that is used for the bone repair of cartilage, constitute by pedestal, it is characterized in that: the overall shape of described pedestal is a cylinder, one end of described cylinder pedestal is simulation cartilage sample layer, its other end is simulation subchondral bone layer, described two-layer combining closely is positioned at described simulation subchondral bone layer outer surface and is provided with screw thread.
2. the two-layer compound support that is used for the bone repair of cartilage according to claim 1 is characterized in that: the diameter of described pedestal is 4～12mm.
3. the two-layer compound support that is used for the bone repair of cartilage according to claim 1 and 2, it is characterized in that: the material of described simulation cartilage sample layer adopts chitin, chitin collagen, fibrin, alginate, fibroin, polylactic acid, polyglycolic acid, the mixture of one or more in polylactic acid-polyglycolic acid copolymer; The material of described simulation subchondral bone layer adopts hydroxyapatite, tricalcium phosphate, polyether-ether-ketone, polylactic acid-polyglycolic acid copolymer, polyglycolic acid, polylactic acid, the mixture of one or more in the fibroin.
4. the two-layer compound support that is used for the bone repair of cartilage according to claim 3 is characterized in that: the thickness of described simulation cartilage sample layer is 1～5mm, and the porosity of this layer is 70～90%, and its aperture is 200～400 μ m; The thickness of described simulation subchondral bone layer is 2～20mm, and the porosity of this layer is 50～75%, and its aperture is 200～500 μ m.
5. a two-layer compound support that is used for the bone repair of cartilage is made of pedestal, it is characterized in that: the overall shape of described pedestal is a wedge type, and the big end of described wedge type pedestal is simulation subchondral bone layer, described two-layer combining closely for simulation cartilage sample layer, its other end.
6. the two-layer compound support that is used for the bone repair of cartilage according to claim 5 is characterized in that: the cross section of described wedge type is square or approximate positive square, and the cornerwise length in its cross section is 4～12mm.
7. according to claim 5 or the 6 described two-layer compound supports that are used for the bone repair of cartilage, it is characterized in that: the material of described simulation cartilage sample layer adopts chitin, chitin collagen, fibrin, alginate, fibroin, polylactic acid, polyglycolic acid, the mixture of one or more in polylactic acid-polyglycolic acid copolymer; The material of described simulation subchondral bone layer adopts hydroxyapatite, tricalcium phosphate, polyether-ether-ketone, polylactic acid-polyglycolic acid copolymer, polyglycolic acid, polylactic acid, the mixture of one or more in the fibroin.
8. the two-layer compound support that is used for the bone repair of cartilage according to claim 7 is characterized in that: the thickness of described simulation cartilage sample layer is 1～5mm, and the porosity of this layer is 70～90%, and its aperture is 200～400 μ m; The thickness of described simulation subchondral bone layer is 2～20mm, and the porosity of this layer is 50～75%, and its aperture is 200～500 μ m.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100521713A CN101219069A (en) | 2008-01-25 | 2008-01-25 | Double-layer composite bracket for renovating cartilage |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100521713A CN101219069A (en) | 2008-01-25 | 2008-01-25 | Double-layer composite bracket for renovating cartilage |
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| CNA2008100521713A Pending CN101219069A (en) | 2008-01-25 | 2008-01-25 | Double-layer composite bracket for renovating cartilage |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102151155A (en) * | 2011-04-26 | 2011-08-17 | 卫小春 | Tool and method for establishing experimental model for researching influence of environments in articular cavity and under cartilage to articular cartilage |
| CN102526809A (en) * | 2012-03-06 | 2012-07-04 | 四川大学华西医院 | Scaffold for osteochondral defect repair and preparation method thereof |
| CN102935019A (en) * | 2012-10-19 | 2013-02-20 | 华中科技大学 | Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof |
| WO2013023610A1 (en) * | 2011-08-17 | 2013-02-21 | 上海微创医疗器械（集团）有限公司 | Multilayer degradable stent with shape memory property and preparation method thereof |
| CN103100113A (en) * | 2011-11-11 | 2013-05-15 | Hoya株式会社 | Artificial bone-cartilage composite and its production method |
| CN101874751B (en) * | 2009-04-30 | 2013-07-10 | 复旦大学 | Multi-layer porous scaffold and preparation method thereof |
| CN103505762A (en) * | 2013-09-27 | 2014-01-15 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| CN103893818A (en) * | 2014-03-14 | 2014-07-02 | 华南理工大学 | Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof |
| WO2014190591A1 (en) * | 2013-05-28 | 2014-12-04 | 上海交通大学医学院附属第九人民医院 | Biphasic scaffold for tissue engineered joint, and preparation method and use thereof |
| CN106178126A (en) * | 2016-07-16 | 2016-12-07 | 遵义市第人民医院 | A kind of reparation bone cartilage two-phase porous compound support frame and preparation method thereof |
| CN107469148A (en) * | 2017-07-28 | 2017-12-15 | 广东泰宝医疗器械技术研究院有限公司 | A kind of new type bone repair of cartilage support and preparation method thereof |
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| CN108201632A (en) * | 2016-12-20 | 2018-06-26 | 重庆润泽医药有限公司 | A kind of articular cartilage repaiies scaffold |
| CN110420356A (en) * | 2019-08-09 | 2019-11-08 | 福州大学 | A kind of Dual-functional integrated bone-cartilage complex tissue engineering rack for osteosarcoma clinical treatment |
| CN116271209A (en) * | 2023-03-03 | 2023-06-23 | 北京爱康宜诚医疗器材有限公司 | Cartilage repair product, preparation method and application thereof |
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| CN101874751B (en) * | 2009-04-30 | 2013-07-10 | 复旦大学 | Multi-layer porous scaffold and preparation method thereof |
| CN102151155B (en) * | 2011-04-26 | 2013-02-27 | 卫小春 | Tool and method for establishing experimental model for researching influence of environments in articular cavity and under cartilage to articular cartilage |
| CN102151155A (en) * | 2011-04-26 | 2011-08-17 | 卫小春 | Tool and method for establishing experimental model for researching influence of environments in articular cavity and under cartilage to articular cartilage |
| WO2013023610A1 (en) * | 2011-08-17 | 2013-02-21 | 上海微创医疗器械（集团）有限公司 | Multilayer degradable stent with shape memory property and preparation method thereof |
| CN103100113A (en) * | 2011-11-11 | 2013-05-15 | Hoya株式会社 | Artificial bone-cartilage composite and its production method |
| CN102526809A (en) * | 2012-03-06 | 2012-07-04 | 四川大学华西医院 | Scaffold for osteochondral defect repair and preparation method thereof |
| CN102935019B (en) * | 2012-10-19 | 2016-01-06 | 华中科技大学 | A kind of preparation method of the gradient lamination porous support based on microsphere selective laser sintering |
| CN102935019A (en) * | 2012-10-19 | 2013-02-20 | 华中科技大学 | Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof |
| WO2014190591A1 (en) * | 2013-05-28 | 2014-12-04 | 上海交通大学医学院附属第九人民医院 | Biphasic scaffold for tissue engineered joint, and preparation method and use thereof |
| CN103505762A (en) * | 2013-09-27 | 2014-01-15 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| CN103505762B (en) * | 2013-09-27 | 2015-06-10 | 中国人民解放军第四军医大学 | Silk bracket as well as preparation method and application thereof, and three-phase silk ligament graft and preparation method thereof |
| CN103893818A (en) * | 2014-03-14 | 2014-07-02 | 华南理工大学 | Osteochondral three-dimensional stent with regular interpenetrating network structure and preparation method thereof |
| CN106178126A (en) * | 2016-07-16 | 2016-12-07 | 遵义市第人民医院 | A kind of reparation bone cartilage two-phase porous compound support frame and preparation method thereof |
| CN108201634A (en) * | 2016-12-20 | 2018-06-26 | 重庆润泽医药有限公司 | A kind of joint repair stent |
| CN108201632A (en) * | 2016-12-20 | 2018-06-26 | 重庆润泽医药有限公司 | A kind of articular cartilage repaiies scaffold |
| CN108201634B (en) * | 2016-12-20 | 2020-09-29 | 重庆润泽医药有限公司 | Bracket for joint repair |
| CN107469148A (en) * | 2017-07-28 | 2017-12-15 | 广东泰宝医疗器械技术研究院有限公司 | A kind of new type bone repair of cartilage support and preparation method thereof |
| CN110420356A (en) * | 2019-08-09 | 2019-11-08 | 福州大学 | A kind of Dual-functional integrated bone-cartilage complex tissue engineering rack for osteosarcoma clinical treatment |
| CN116271209A (en) * | 2023-03-03 | 2023-06-23 | 北京爱康宜诚医疗器材有限公司 | Cartilage repair product, preparation method and application thereof |
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