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CN101213164A - 二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途 - Google Patents

二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途 Download PDF

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CN101213164A
CN101213164A CNA2006800014830A CN200680001483A CN101213164A CN 101213164 A CN101213164 A CN 101213164A CN A2006800014830 A CNA2006800014830 A CN A2006800014830A CN 200680001483 A CN200680001483 A CN 200680001483A CN 101213164 A CN101213164 A CN 101213164A
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methoxyl group
naphthalenes
dihydros
methylol
aldehyde radical
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CN101213164B (zh
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周应军
史跃年
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Darui Technology Investment Co ltd
Central South University
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Darui Technology Investment Co ltd
Central South University
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    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

一种具有Akt抑制活性的如下通式的芳基二氢萘类木脂素衍生物，以及该化合物和含有该化合物的药物组合物通过抑制Akt活性通路治疗癌症的方法。其中，X为C＝O、C＝S、C＝N、亚甲基或烯基；Y是氢原子、羟基、氨基、烷基或没有Y基团；R1、R2分别为氢原子、烷基、烯基、葡萄糖基、葡萄糖醛酸基、酰基或芳基；R3为氢原子或葡萄糖基；R4为甲氧基或氢原子；R5为甲氧基或氢原子；母核中三位和四位的氢为(3R，4S)。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2006800014830A 2005-12-30 2006-12-30 二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途 Expired - Fee Related CN101213164B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2006800014830A CN101213164B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200510136656.7 2005-12-30
CNA2005101366567A CN1990445A (zh) 2005-12-30 2005-12-30 芳基二氢萘类木脂素衍生物及其用途
PCT/CN2006/003703 WO2007076704A1 (fr) 2005-12-30 2006-12-30 COMPOSÉS DE DIHYDRO-NAPHTALÈNE D'ARYLE, LEUR PRÉPARATION ET LEUR UTILISATION COMME INHIBITEUR D'Akt POUR LA PRÉVENTION ET LE TRAITEMENT DU CANCER
CN2006800014830A CN101213164B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途

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CN2010101813646A Division CN101972267B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物在制备治疗与预防肿瘤药物中的用途

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CN101213164A true CN101213164A (zh) 2008-07-02
CN101213164B CN101213164B (zh) 2011-06-22

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CNA2005101366567A Pending CN1990445A (zh) 2005-12-30 2005-12-30 芳基二氢萘类木脂素衍生物及其用途
CN2010101813646A Expired - Fee Related CN101972267B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物在制备治疗与预防肿瘤药物中的用途
CN2006800014830A Expired - Fee Related CN101213164B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物，制备方法以及作为Akt抑制剂预防与治疗癌症的用途

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CNA2005101366567A Pending CN1990445A (zh) 2005-12-30 2005-12-30 芳基二氢萘类木脂素衍生物及其用途
CN2010101813646A Expired - Fee Related CN101972267B (zh) 2005-12-30 2006-12-30 二氢芳基萘类化合物在制备治疗与预防肿瘤药物中的用途

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EP (1) EP1972611A1 (zh)
JP (1) JP2009522212A (zh)
CN (3) CN1990445A (zh)
WO (1) WO2007076704A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114262270A (zh) * 2022-01-10 2022-04-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种芳基二氢萘木脂素类化合物及其制备方法以及应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258502B (zh) * 2010-05-28 2015-05-06 中南大学 二氢芳基萘类木脂素衍生物及其组合物用于制备预防和治疗乳腺增生药物的应用
CN102349886B (zh) * 2011-07-05 2013-04-24 中国人民解放军第二军医大学 苯代萘型木脂素类化合物在制备抗辐射药物中的应用
CN103127159A (zh) * 2013-02-05 2013-06-05 广西壮族自治区药用植物园 一种芳基萘型木脂素在治疗丙型病毒性肝炎(hcv)中的应用
CN104447364B (zh) * 2013-09-18 2017-05-17 中南大学 4`‑位氮烷基取代二氢芳基萘类木脂素化合物及其在制备治疗与预防肿瘤药物中的应用
CN103467463B (zh) * 2013-09-18 2016-06-22 南开大学 一类木脂素类衍生物及其制备方法和用途
CN103860528A (zh) * 2014-01-21 2014-06-18 中国人民解放军第二军医大学 一种芳基萘型木脂素在制备抗前列腺癌药物中的应用
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
CN110563781B (zh) * 2019-09-30 2021-06-25 江南大学 一种合欢皮新木脂体单体化合物的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284789B1 (en) * 1998-09-04 2001-09-04 The Research Foundation Of State University Of New York Formation and composition of new optically active compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114262270A (zh) * 2022-01-10 2022-04-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种芳基二氢萘木脂素类化合物及其制备方法以及应用
CN114262270B (zh) * 2022-01-10 2023-07-07 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种芳基二氢萘木脂素类化合物及其制备方法以及应用

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Publication number Publication date
CN101972267B (zh) 2012-09-05
CN101213164B (zh) 2011-06-22
EP1972611A1 (en) 2008-09-24
CN101972267A (zh) 2011-02-16
JP2009522212A (ja) 2009-06-11
WO2007076704A1 (fr) 2007-07-12
CN1990445A (zh) 2007-07-04

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