CN101185574A - Vacuum hemostix tube mouth membranization agent and uses thereof - Google Patents
Vacuum hemostix tube mouth membranization agent and uses thereof Download PDFInfo
- Publication number
- CN101185574A CN101185574A CNA2007100507088A CN200710050708A CN101185574A CN 101185574 A CN101185574 A CN 101185574A CN A2007100507088 A CNA2007100507088 A CN A2007100507088A CN 200710050708 A CN200710050708 A CN 200710050708A CN 101185574 A CN101185574 A CN 101185574A
- Authority
- CN
- China
- Prior art keywords
- blood
- mouth
- tube
- membranization
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000973497 Siphonognathus argyrophanes Species 0.000 title claims abstract description 22
- 210000004369 blood Anatomy 0.000 claims abstract description 43
- 239000008280 blood Substances 0.000 claims abstract description 43
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 38
- -1 methyl siloxane Chemical class 0.000 claims abstract description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 20
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 20
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 20
- 238000012360 testing method Methods 0.000 claims abstract description 17
- 239000002202 Polyethylene glycol Substances 0.000 claims description 17
- 229920001223 polyethylene glycol Polymers 0.000 claims description 17
- 239000000126 substance Substances 0.000 claims description 17
- 238000003618 dip coating Methods 0.000 claims description 9
- 230000023555 blood coagulation Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 5
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 7
- 238000007789 sealing Methods 0.000 abstract description 7
- 239000012528 membrane Substances 0.000 abstract 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 2
- 239000004721 Polyphenylene oxide Substances 0.000 abstract 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003921 oil Substances 0.000 abstract 2
- 229920000570 polyether Polymers 0.000 abstract 2
- 229910052710 silicon Inorganic materials 0.000 abstract 2
- 239000010703 silicon Substances 0.000 abstract 2
- 238000004159 blood analysis Methods 0.000 abstract 1
- 239000011521 glass Substances 0.000 description 7
- 230000021164 cell adhesion Effects 0.000 description 6
- 229920005549 butyl rubber Polymers 0.000 description 5
- 229920002545 silicone oil Polymers 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000001464 adherent effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a tube mouth membrane agent used for a test tube and a blood collection tube made of the tube mouth membrane agent. The tube mouth membrane agent comprises adsorbable inorganic matter, hardly water-insoluble Polyethylene oxide, and polyvinylpyrrolidone and polyether methyl siloxane which add up to 100 wt%. The optimal technical proposal is 15 wt% adsorbable inorganic matter, 30 wt% Polyethylene oxide, 30 wt% polyvinylpyrrolidone and 25 wt% polyether methyl siloxane. as the mouth of the blood collecting tube is coated by the membrane agent under the vacuum pressure of 80-100Pa, the invention solves the problems of poor sealing performance of the existing blood collecting tube and adhesion of erythrocytes to the blood collecting tube in the prior art, which can effectively avoid the adhesion of erythrocytes to blood collecting tube in the process of inverting and mixing of blood when collecting blood in clinic. The invention does not coat silicon oil with high concentration in the blood collecting tube in prior art, so as to avoid the influence of the silicon oil with high concentration on the experimental process and ensure the correctness of the results of blood analysis.
Description
Technical field
The present invention relates to the blood taking tube that a kind of mouth membranization agent that is applied to test tube is made with using this mouth membranization agent.
Background technology
At present, on the vacuum test tube mouth of pipe is handled, most of enterprise be untreated or treatment effect not good, butyl rubber bung has red blood cell adhesion and sealing not good with the teat glass contact site in the centrifugal back of blood taking tube blood drawing, thereby influence product testing result and shortening shelf life of products.In blood test, make the blood coagulation of collecting in the blood collection tube earlier, centrifugal then to separate the blood constituent of expection.In order to reach ideal analysis result, require this blood collection tube to have the ideal blood coagulation that is collected in the blood collection tube that makes at short notice and promote ability, adhere to the form and the blood collecting inside pipe wall of the blood that prevents to solidify with clot, the clot that adherent clot is broken away from breaks away from ability, to prevent that clinical collection blood from putting upside down in the mixed process, red blood cell adhesion is in the test tube mouth of pipe.Japan has examined open HEI-5-10095 and discloses a kind of blood collection tube, wherein the inwall of the container of being made by special material is coated with blood coagulation accelerator, this blood coagulation accelerator comprises water-insoluble silicone oil, the inorganic substances of polyvinylpyrrolidone and adsorptivity.Behind the aforesaid inwall, make the blood of collection can solidify at short notice and prevent that the inwall of clot and this pipe from adhering to coagulation accelerator coating blood collection tube.Yet, in this blood collection tube, need to apply the silicone oil of high concentration, so that preventing clot and inside pipe wall adheres to, and the existence of the silicone oil of high concentration may be to the test value adverse influence, in addition, when these blood collection tubes have stopper member, there is the adherent problem of clot and stopper member when collecting the blood coagulation in the blood collection tube.
Summary of the invention
In order to solve existing blood taking tube red blood cell adhesion and the not good problem of blood taking tube sealing, the invention provides a kind of membranization agent, by the teat glass mouth of pipe is smeared, can prevent effectively that clinical collection blood from putting upside down in the mixed process, red blood cell adhesion is in the mouth of pipe, solved thoroughly that erythrocyte is sticking tells and sealing problem.
The present invention also provides a kind of vacuum test tube of using this mouth membranization agent.
Technical scheme of the present invention realizes by following content:
A kind of vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, gather 100 weight portions altogether of mystery methylsiloxane.
According to mouth membranization agent of the present invention, be preferably adsorptivity inorganic substances 10-20 weight portion, polyethylene glycol oxide 20-40 weight portion, polyvinylpyrrolidone 15-30 weight portion, poly-mystery methylsiloxane 20-40 weight portion.
According to mouth membranization agent of the present invention, most preferably be adsorptivity inorganic substances 15 weight portions, polyethylene glycol oxide 30 weight portions, polyvinylpyrrolidone 30 weight portions, poly-mystery methylsiloxane 25 weight portions.
A kind of vacuum test tube is formed by the tubular container with bottom, and this blood collection tube holds blood coagulation accelerator of the present invention.
According to vacuum test tube of the present invention, the membranization agent of being made up of above reagent acts on dip-coating in the blood taking tube mouth of pipe under vacuum pressure 80-100Pa, forms the wide cured film of 2-4mm.
The polyethylene glycol oxide that the present invention uses has good cementability and film property, has guaranteed every the sealing of glass from test tube and butyl rubber bung;
Polyvinylpyrrolidone has good hygroscopicity, film property and biocompatibility;
The poly-mystery methylsiloxane of poly-mystery methylsiloxane can fully be isolated test tube, butyl rubber bung directly contacts with blood, prevents that effectively hemocyte from reaching the adhesion of butyl rubber bung inner surface around the mouth of pipe.
The membranization agent of being made up of above reagent makes the reagent dip-coating in the blood taking tube mouth of pipe through the vacuum pressure effect.Dry back forms the cured film that 3mm is wide in mouth of pipe place.This cured film can prevent effectively that clinical collection blood from putting upside down in the mixed process, adheres to the erythrocyte of the mouth of pipe.And guaranteed every the sealing of glass from test tube and butyl rubber bung.
The present invention utilizes vacuum pressure to act on blood taking tube mouth of pipe dip-coating membranization agent, solved the not good problem of existing blood taking tube sealing on the one hand, the problem of red blood cell adhesion blood taking tube in the prior art has been removed in the membranization agent of dip-coating simultaneously, can prevent effectively that clinical collection blood from putting upside down in the mixed process, red blood cell adhesion is in the mouth of pipe.In addition, the present invention does not adopt the high concentration silicone oil that applies in the prior art in blood collection tube, has avoided the influence of high concentration silicone oil to process of the test, has guaranteed hemanalysis result's correctness.
The specific embodiment
Embodiment 1
A kind of vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, gather 100 weight portions altogether of mystery methylsiloxane.Wherein adsorptivity inorganic substances 15 weight portions, polyethylene glycol oxide 30 weight portions, polyvinylpyrrolidone 30 weight portions, poly-mystery methylsiloxane 25 weight portions.
Embodiment 2
A kind of vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, gather 100 weight portions altogether of mystery methylsiloxane.Wherein adsorptivity inorganic substances 15 weight portions, polyethylene glycol oxide 35 weight portions, polyvinylpyrrolidone 30 weight portions, poly-mystery methylsiloxane 20 weight portions.
Embodiment 3
A kind of vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, gather 100 weight portions altogether of mystery methylsiloxane.Wherein adsorptivity inorganic substances 20 weight portions, polyethylene glycol oxide 20 weight portions, polyvinylpyrrolidone 20 weight portions, poly-mystery methylsiloxane 40 weight portions.
Embodiment 4
A kind of vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, gather 100 weight portions altogether of mystery methylsiloxane.Wherein adsorptivity inorganic substances 20 weight portions, polyethylene glycol oxide 40 weight portions, polyvinylpyrrolidone 20 weight portions, poly-mystery methylsiloxane 20 weight portions.
Embodiment 5
A kind of vacuum test tube is formed by the glass tubular container with bottom, in this blood taking tube mouth of pipe dip-coating the membranization agent is arranged.Described membranization agent is made of adsorptivity inorganic substances 15 weight portions, polyethylene glycol oxide 30 weight portions, polyvinylpyrrolidone 30 weight portions, poly-mystery methylsiloxane 25 weight portions.This membranization agent dip-coating under vacuum pressure 80Pa effect forms the wide cured film of 2mm in the blood taking tube mouth of pipe.
Embodiment 6
A kind of glass vacuum test tube is formed by the glass tubular container with bottom, in this blood taking tube mouth of pipe dip-coating the membranization agent is arranged.Described membranization agent is made of adsorptivity inorganic substances 20 weight portions, polyethylene glycol oxide 40 weight portions, polyvinylpyrrolidone 20 weight portions, poly-mystery methylsiloxane 20 weight portions.This membranization agent dip-coating under vacuum pressure 100Pa effect forms the wide cured film of 4mm in the blood taking tube mouth of pipe.
Claims (5)
1. vacuum hemostix tube mouth membranization agent, described mouth membranization agent comprise 100 weight portions altogether of adsorptivity inorganic substances and almost water-fast polyethylene glycol oxide, polyvinylpyrrolidone, poly-mystery methylsiloxane.
2. vacuum according to claim 1 is the blood vessel mouth membranization agent, it is characterized in that:, be preferably adsorptivity inorganic substances 10-20 weight portion, polyethylene glycol oxide 20-40 weight portion, polyvinylpyrrolidone 15-30 weight portion, poly-mystery methylsiloxane 20-40 weight portion according to mouth membranization agent of the present invention.
3. vacuum according to claim 1 is the blood vessel mouth membranization agent, it is characterized in that:, most preferably be adsorptivity inorganic substances 15 weight portions, polyethylene glycol oxide 30 weight portions, polyvinylpyrrolidone 30 weight portions, poly-mystery methylsiloxane 25 weight portions according to mouth membranization agent of the present invention.
4. a vacuum test tube is formed by the tubular container with bottom, and this blood collection tube holds blood coagulation accelerator of the present invention.
5. vacuum test tube according to claim 4 is characterized in that: the dip-coating under vacuum pressure 80-100Pa effect of claim 1,2 or 3 described any one vacuum hemostix tube mouth membranization agents is formed the wide cured film of 2-4mm in the blood taking tube mouth of pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100507088A CN101185574A (en) | 2007-12-05 | 2007-12-05 | Vacuum hemostix tube mouth membranization agent and uses thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100507088A CN101185574A (en) | 2007-12-05 | 2007-12-05 | Vacuum hemostix tube mouth membranization agent and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101185574A true CN101185574A (en) | 2008-05-28 |
Family
ID=39478349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100507088A Pending CN101185574A (en) | 2007-12-05 | 2007-12-05 | Vacuum hemostix tube mouth membranization agent and uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101185574A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102033007A (en) * | 2009-09-30 | 2011-04-27 | 希森美康株式会社 | Blood sample processing apparatus and blood sample processing method |
| CN108780083A (en) * | 2016-01-06 | 2018-11-09 | 瑞帕利克斯有限公司 | Suitable for the clot-promoting factor subsequently used self |
| US12011463B2 (en) | 2008-08-22 | 2024-06-18 | Reapplix Aps | Multilayered blood product |
-
2007
- 2007-12-05 CN CNA2007100507088A patent/CN101185574A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12011463B2 (en) | 2008-08-22 | 2024-06-18 | Reapplix Aps | Multilayered blood product |
| CN102033007A (en) * | 2009-09-30 | 2011-04-27 | 希森美康株式会社 | Blood sample processing apparatus and blood sample processing method |
| CN102033007B (en) * | 2009-09-30 | 2014-03-12 | 希森美康株式会社 | Blood sample processing apparatus and blood sample processing method |
| CN108780083A (en) * | 2016-01-06 | 2018-11-09 | 瑞帕利克斯有限公司 | Suitable for the clot-promoting factor subsequently used self |
| US12029561B2 (en) | 2016-01-06 | 2024-07-09 | Reapplix Aps | Procoagulant factors suitable for subsequent autologous use |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1178257A (en) | Apparatus for separating blood | |
| Kovach et al. | The effects of PEG‐based surface modification of PDMS microchannels on long‐term hemocompatibility | |
| US6551267B1 (en) | Medical article having blood-contacting surface | |
| JP4266637B2 (en) | Microbial detection | |
| WO2013115331A1 (en) | Syringe for use as pre-filled syringe | |
| CN101185574A (en) | Vacuum hemostix tube mouth membranization agent and uses thereof | |
| CN105283521A (en) | Surface treatment agent for surface configured from inorganic material, tool and device having modified surface, and method for manufacturing tool and device | |
| JPH09173321A (en) | Blood taking appliance for plasma separation and blood taking method | |
| WO2011100595A2 (en) | Methods and devices for sample collection, treatment and dispensing | |
| WO2010024325A1 (en) | Blood collection container | |
| KR20140008378A (en) | Culture vessel for forming embryoid body | |
| Hasebe et al. | Hydrophobicity and non-thrombogenicity of nanoscale dual rough surface coated with fluorine-incorporated diamond-like carbon films: Biomimetic surface for blood-contacting medical devices | |
| CN108507941A (en) | A kind of detection method of polymeric coating layer fastness | |
| JP3984407B2 (en) | Glass products | |
| CN107748095B (en) | Multipurpose sputum specimen processing device and method thereof | |
| CN115413296A (en) | Cell culture substrates, methods and uses thereof | |
| CN211282199U (en) | A mercury drop manual collection device | |
| CN109932364A (en) | Stool examination device | |
| JP2536921B2 (en) | Blood collection tube | |
| JPH08275932A (en) | Blood-gathering device | |
| CN113329691B (en) | Anti-clot adhesive and blood collection container | |
| JP3495106B2 (en) | Blood component adhesion preventing agent, blood test container and blood component adhesion preventing carrier | |
| RU193728U1 (en) | TWO-SECTION TUBE WITH FILM COATING WITH SAMPLE AND COVER FOR CORRECTION OF THE TEST | |
| JPH0573174B2 (en) | ||
| CN110423374A (en) | In the method that microfluidic channel plate surface prepares wettability gradient |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080528 |