CN101161274B - A Chinese medicine composition for treating gout - Google Patents
A Chinese medicine composition for treating gout Download PDFInfo
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- CN101161274B CN101161274B CN2006101496565A CN200610149656A CN101161274B CN 101161274 B CN101161274 B CN 101161274B CN 2006101496565 A CN2006101496565 A CN 2006101496565A CN 200610149656 A CN200610149656 A CN 200610149656A CN 101161274 B CN101161274 B CN 101161274B
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- 239000003814 drug Substances 0.000 title claims abstract description 61
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 201000005569 Gout Diseases 0.000 title claims abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 122
- 239000009636 Huang Qi Substances 0.000 claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 37
- 239000007788 liquid Substances 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 21
- 239000006071 cream Substances 0.000 claims abstract description 19
- 239000008187 granular material Substances 0.000 claims abstract description 19
- 238000001035 drying Methods 0.000 claims abstract description 18
- 239000002775 capsule Substances 0.000 claims abstract description 15
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- 238000002360 preparation method Methods 0.000 claims abstract description 6
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- 238000004064 recycling Methods 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 21
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims description 17
- 239000002244 precipitate Substances 0.000 claims description 17
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 235000019634 flavors Nutrition 0.000 claims description 13
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- 238000000034 method Methods 0.000 claims description 7
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- 238000011084 recovery Methods 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract 2
- 240000005528 Arctium lappa Species 0.000 abstract 1
- 235000003130 Arctium lappa Nutrition 0.000 abstract 1
- 241000218158 Clematis Species 0.000 abstract 1
- 241000846172 Cremastra appendiculata Species 0.000 abstract 1
- 244000163122 Curcuma domestica Species 0.000 abstract 1
- 235000003392 Curcuma domestica Nutrition 0.000 abstract 1
- 240000009138 Curcuma zedoaria Species 0.000 abstract 1
- 235000003405 Curcuma zedoaria Nutrition 0.000 abstract 1
- 241000514824 Cyathula officinalis Species 0.000 abstract 1
- 241001404789 Smilax glabra Species 0.000 abstract 1
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- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
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- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 4
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Abstract
A traditional Chinese medicinal composition for treating gout is disclosed in the present invention, the traditional Chinese medicinal composition is composed of radix astragali 10 to 50 weight amount, smilax glabra 20 to 120 weight amount, cyathula officinalis 10 to 50 weight amount, and cremastra appendiculata 5 to 30 weight amount, on the basis, also adding great burdock achene, sparganium stoloniferum, zedoary turmeric clematis root and etc. raw materials. The preparation method of the traditional Chinese medicinal composition raw materials is: weighting raw materials, adding water to decoct 2 to 3 times, each time 5 to 15 times amount, decocting 0.5 to 2 hours, combining medicine liquid, filtering, reduced pressure concentrating the filtering liquid to recovery ethanol, concentrating to relative density is 1.05 to 1.25 detected under 50 to 60 C DEG, drying, obtaining dried cream; grinding dried cream into fine powder, adding proper supplementary to prepare granule, pill, capsule or tablet orally-administrated solid preparations. The traditional Chinese medicinal composition of the present invention can be used for treating gout.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of gout.
Background technology
Gout is because due to the long-term purine metabolic disturbance, clinical in hyperuricemia, acute arthritis is shown effect repeatedly, the tophus deposition, and chronic arthritis and joint deformity, urate nephropathy and urate calculus are a class disease of feature.Motherland's medical science belongs to " arthromyodynia " category to rheumatisms such as " gout " and rheumatic arthritis system.Its pathogenesis mainly is human righteousness's deficiency, imbalance of YIN and YANG, and pathological products such as the damp and hot expectorant stasis of blood gather in body, the meridians of being detained, multiple because of improper diet and overtiredness, chamber does not save, being invaded by exogenous pathogen, inside and outside combined pathogens, coagulation of QI-blood is obstructed and take place.In recent years along with the raising of people's living standard, the variation of dietary structure, the quickening of work rhythm, its sickness rate is obvious ascendant trend in China.
Though the Western medicine of many treatment gouts is arranged at present, but toxic and side effects is all very big, and must continues to take, seriously perplexing people's health and work.Motherland's medical science early has argumentation to " gout " is sick, and has accumulated abundant effective side's medicine and method, and than doctor trained in Western medicine motherland medical science determined curative effect, untoward reaction is little, need not long-lasting advantage such as take medicine.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine composition for the treatment of gout; Second purpose of the present invention is to provide a kind of preparation method of this Chinese medicine composition.
The present invention seeks to be achieved through the following technical solutions.
Crude drug forms one:
Chinese medicine composition of the present invention is made up of following bulk drugs:
Radix Astragali 10-50 weight portion Rhizoma Smilacis Glabrae 20-120 weight portion
Radix Cyathulae 10-50 weight portion Pseudobulbus Cremastrae Seu Pleiones 5-30 weight portion.
Described traditional Chinese medicinal composition raw materials of the present invention is preferably as follows weight portion:
The Radix Astragali 30 weight portion Rhizoma Smilacis Glabraes 70 weight portions
Radix Cyathulae 30 weight portion Pseudobulbus Cremastrae Seu Pleioness 18 weight portions.
Described traditional Chinese medicinal composition raw materials of the present invention is preferably as follows weight portion:
The Radix Astragali 15 weight portion Rhizoma Smilacis Glabraes 110 weight portions
Radix Cyathulae 20 weight portion Pseudobulbus Cremastrae Seu Pleioness 25 weight portions.
Described traditional Chinese medicinal composition raw materials of the present invention is preferably as follows weight portion:
The Radix Astragali 40 weight portion Rhizoma Smilacis Glabraes 30 weight portions
Radix Cyathulae 45 weight portion Pseudobulbus Cremastrae Seu Pleioness 8 weight portions.
Crude drug forms two:
Form (prescription one) based on the invention described above traditional Chinese medicinal composition raw materials, also can increase Fructus Arctii simply, crude drug composition and weight portion are as follows:
Radix Astragali 10-50 weight portion Rhizoma Smilacis Glabrae 20-120 weight portion Radix Cyathulae 10-50 weight portion
Pseudobulbus Cremastrae Seu Pleiones 5-30 weight portion Fructus Arctii 10-50 weight portion.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 30 weight portion Rhizoma Smilacis Glabraes 70 weight portion Radix Cyathulaes 30 weight portions
Pseudobulbus Cremastrae Seu Pleiones 18 weight portion Fructus Arctiis 30 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 15 weight portion Rhizoma Smilacis Glabraes 110 weight portion Radix Cyathulaes 20 weight portions
Pseudobulbus Cremastrae Seu Pleiones 25 weight portion Fructus Arctiis 20 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 40 weight portion Rhizoma Smilacis Glabraes 30 weight portion Radix Cyathulaes 45 weight portions
Pseudobulbus Cremastrae Seu Pleiones 8 weight portion Fructus Arctiis 40 weight portions.
Crude drug forms three:
Form on the basis at crude drug, also can increase Radix Clematidis and Radix Saposhnikoviae, crude drug composition and weight portion are as follows:
Radix Astragali l0-50 weight portion Rhizoma Smilacis Glabrae 20-120 weight portion Radix Cyathulae 10-50 weight portion
Pseudobulbus Cremastrae Seu Pleiones 5-30 weight portion Radix Saposhnikoviae 10-50 weight portion Radix Clematidis 10-50 weight portion.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 30 weight portion Rhizoma Smilacis Glabraes 70 weight portion Radix Cyathulaes 30 weight portions
Pseudobulbus Cremastrae Seu Pleiones 18 weight portion Radix Saposhnikoviaes 30 weight portion Radix Clematidis 30 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 15 weight portion Rhizoma Smilacis Glabraes 110 weight portion Radix Cyathulaes 20 weight portions
Pseudobulbus Cremastrae Seu Pleiones 25 weight portion Radix Saposhnikoviaes 12 weight portion Radix Clematidis 40 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 40 weight portion Rhizoma Smilacis Glabraes 30 weight portion Radix Cyathulaes 45 weight portions
Pseudobulbus Cremastrae Seu Pleiones 8 weight portion Radix Saposhnikoviaes 45 weight portion Radix Clematidis 15 weight portions.
Crude drug forms four:
Form on two bases at crude drug, also can increase rhizoma sparganic, Rhizoma Curcumae and Radix Clematidis, raw material medicines in portions by weight is composed as follows:
Radix Astragali 10-50 weight portion Rhizoma Smilacis Glabrae 20-120 weight portion Radix Cyathulae 10-50 weight portion
Pseudobulbus Cremastrae Seu Pleiones 5-30 weight portion Fructus Arctii 10-50 weight portion rhizoma sparganic 5-50 weight portion
Rhizoma Curcumae 5-50 weight portion Radix Clematidis 10-50 weight portion.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 30 weight portion Rhizoma Smilacis Glabraes 70 weight portion Radix Cyathulaes 30 weight portions
Pseudobulbus Cremastrae Seu Pleiones 18 weight portion Fructus Arctiis 30 weight portion rhizoma sparganic 30 weight portions
Rhizoma Curcumae 30 weight portion Radix Clematidis 30 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 15 weight portion Rhizoma Smilacis Glabraes 110 weight portion Radix Cyathulaes 20 weight portions
Pseudobulbus Cremastrae Seu Pleiones 25 weight portion Fructus Arctiis 20 weight portion rhizoma sparganic 45 weight portions
Rhizoma Curcumae 8 weight portion Radix Clematidis 42 weight portions.
The invention described above traditional Chinese medicinal composition raw materials is preferably as follows weight portion:
The Radix Astragali 40 weight portion Rhizoma Smilacis Glabraes 30 weight portion Radix Cyathulaes 45 weight portions
Pseudobulbus Cremastrae Seu Pleiones 8 weight portion Fructus Arctiis 40 weight portion rhizoma sparganic 8 weight portions
Rhizoma Curcumae 48 weight portion Radix Clematidis 15 weight portions.
Get above-mentioned any one group of traditional Chinese medicinal composition raw materials of the present invention, technology adds conventional adjuvant and is prepared into clinical acceptable any dosage form routinely, as: powder, capsule, tablet, granule, injection, oral liquid or drop pill etc.
Chinese medicine composition of the present invention can be prepared by following method:
Take by weighing above crude drug, decoct with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds conventional adjuvant and is prepared into oral solid formulations such as granule, pill, capsule or tablet.
The Chinese medicine composition of crude drug composition two of the present invention also can be prepared by following method:
Medicinal 50～80% ethanol extractions of Fructus Arctii, Radix Cyathulae two flavors 2～3 times, each 3～15 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones three flavor medicines, decoct with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds conventional adjuvant and is prepared into oral solid formulations such as granule, pill, capsule or tablet.
The Chinese medicine composition of crude drug composition three of the present invention also can be prepared by following method:
Medicinal 50～80% ethanol extractions of Radix Clematidis, Radix Cyathulae two flavors 2～3 times, each 3～15 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, Radix Saposhnikoviae four Chinese medicine, decoct with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds conventional adjuvant and is prepared into oral solid formulations such as granule, pill, capsule or tablet.
The Chinese medicine composition of crude drug composition four of the present invention also can be prepared by following method:
Medicinal 50～80% ethanol extractions of Radix Clematidis, Fructus Arctii, Radix Cyathulae three flavors 2～3 times, each 3～15 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Rhizoma Curcumae adopts steam distillation to extract volatile oil, and volatile oil device in addition stores for future use; Medicinal liquid device in addition stores for future use; Medicinal residues and Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, rhizoma sparganic four Chinese medicine, decoct with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, above-mentioned medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds the volatile oil that appropriate amount of auxiliary materials and Rhizoma Curcumae extract, and is prepared into oral solid formulations such as granule, pill, capsule or tablet behind the mix homogeneously.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
The clinical research of experimental example pharmaceutical composition of the present invention
All cases are all with reference to 1977 " American Rheumatism Association formulate diagnostic criteria " and China " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " totally 45 examples, male's 41 examples wherein, women's 4 examples; Minimum 20 years old of age, maximum 69 years old; The course of disease is the shortest 13 days, and is the longest 9 years, maximum with 3-5; The first metatarsophalangeal joints person of swelling and ache, 38 examples wherein, a side 34 examples wherein, both sides 11 examples.One-sided arthritis 31 examples have two arthralgia inflammation person 14 examples, and tophus person's 6 examples are arranged.All cases are chamber inspection by experiment all, and blood uric acid increases 44 examples, and in example normal range 1, all patients get rid of medicine and other disease secondary.
Therapeutic Method:
All adopt crude drug of the present invention to form.The 30 examples decoction that is packed in bag, two bags every dose, every bag of 180ml, one day twice, each one bag.15 examples are used granule, every bag of 15g, and every day three times, each one bag, boiled water is taken after mixing it with water.(two bags of decoctions equate with three bags of granule raw medicinal herbs amounts) two weeks is a course of treatment, generally obeys two courses of treatment, finishes observe the curative effect the course of treatment.Few therebetween movable, high purine food is not advanced in alleviating alcohol addiction.
Efficacy assessment standard:
The recovery from illness: clinical symptoms all disappears, joint motion freely, blood uric acid is reduced to normal range; Produce effects: clinical symptoms takes a turn for the better, and joint motion is flexible, and the more preceding reduction of blood uric acid is more than 10%; Invalid: symptom and lab testing no change.
The result:
Recovery from illness: 33 examples account for 73%; Produce effects: 9 examples account for 20%; Invalid: 3 examples 7%; Total effective rate is 93%.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: decoction of the present invention
Radix Astragali 30kg Rhizoma Smilacis Glabrae 70kg Radix Cyathulae 30kg Pseudobulbus Cremastrae Seu Pleiones 18kg.
Get the above-mentioned raw materials medicine, prepared is fried in shallow oil into decoction routinely, is packed in bag every bag of 180ml, stored refrigerated, one day twice, each one bag.
Embodiment 2: granule of the present invention
Radix Astragali 15kg Rhizoma Smilacis Glabrae 110kg Radix Cyathulae 20kg Pseudobulbus Cremastrae Seu Pleiones 25kg.
Above four Chinese medicine decocts with water 2 times, each 10 times of amounts, decoction 2 hours, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 70% precipitate with ethanol, left standstill 12 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into granule.Every bag of 15g, every day three times, each one bag, boiled water is taken after mixing it with water.
Embodiment 3: tablet of the present invention
Radix Astragali 40kg Rhizoma Smilacis Glabrae 30kg Radix Cyathulae 45kg Pseudobulbus Cremastrae Seu Pleiones 8kg.
Above four Chinese medicine decocts with water 3 times, each 6 times of amounts, decoction 1 hour, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 60% precipitate with ethanol, left standstill 20 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into tablet.
Embodiment 4: granule of the present invention
Radix Astragali 30kg Rhizoma Smilacis Glabrae 70kg Radix Cyathulae 30kg Pseudobulbus Cremastrae Seu Pleiones 18kg Fructus Arctii 30kg.
Above five kinds of Chinese medicine decocts with water 3 times, each 10 times of amounts, decoction 1 hour, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 70% precipitate with ethanol, left standstill 15 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into granule.
Embodiment 5: pill of the present invention
Radix Astragali 15kg Rhizoma Smilacis Glabrae 110kg Radix Cyathulae 20kg Pseudobulbus Cremastrae Seu Pleiones 25kg Fructus Arctii 20kg.
Medicinal 60% ethanol extraction of Fructus Arctii, Radix Cyathulae two flavors 3 times, each 5 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones three flavor medicines, decoct with water 2 times, each 10 times of amounts, decoction 1 hour, medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into pill.
Embodiment 6: capsule of the present invention
Radix Astragali 40kg Rhizoma Smilacis Glabrae 30kg Radix Cyathulae 45kg Pseudobulbus Cremastrae Seu Pleiones 8kg Fructus Arctii 40kg.
Medicinal 70% ethanol extraction of Fructus Arctii, Radix Cyathulae two flavors 2 times, each 10 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones three flavor medicines, decoct with water 3 times, each 6 times of amounts, decoction 2 hours, medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 12 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into capsule.
Embodiment 7: granule of the present invention
Radix Astragali 30kg Rhizoma Smilacis Glabrae 70kg Radix Cyathulae 30kg
Pseudobulbus Cremastrae Seu Pleiones 18kg Radix Saposhnikoviae 30kg Radix Clematidis 30kg.
Above Six-element medicine decocts with water 3 times, each 6 times of amounts, decoction 2 hours, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 50～80% precipitate with ethanol, left standstill 124 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into granule.
Embodiment 8: tablet of the present invention
Radix Astragali 15kg Rhizoma Smilacis Glabrae 110kg Radix Cyathulae 20kg
Pseudobulbus Cremastrae Seu Pleiones 25kg Radix Saposhnikoviae 12kg Radix Clematidis 40kg.
Above Six-element medicine decocts with water 2 times, each 10 times of amounts, decoction 0.5 hour, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 50～80% precipitate with ethanol, left standstill 12 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into tablet.
Embodiment 9: capsule of the present invention
Radix Astragali 40kg Rhizoma Smilacis Glabrae 30kg Radix Cyathulae 45kg
Pseudobulbus Cremastrae Seu Pleiones 8kg Radix Saposhnikoviae 45kg Radix Clematidis 15kg.
Medicinal 70% ethanol extraction of Radix Clematidis, Radix Cyathulae two flavors 3 times, each 10 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, Radix Saposhnikoviae four Chinese medicine, decoct with water 2 times, each 10 times of amounts, decoction 1.5 hours, medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 70% precipitate with ethanol, left standstill 24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into capsule.
Embodiment 10: granule of the present invention
Radix Astragali 30kg Rhizoma Smilacis Glabrae 70kg Radix Cyathulae 30kg Pseudobulbus Cremastrae Seu Pleiones 18kg
Fructus Arctii 30kg rhizoma sparganic 30kg Rhizoma Curcumae 30kg Radix Clematidis 30kg.
More than eight the flavor medicines, decoct with water 2 times, each 15 times of amounts, the decoction 2 hours, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 60% precipitate with ethanol, left standstill 12 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds appropriate amount of auxiliary materials and is prepared into granule.
Embodiment 11: pill of the present invention
Radix Astragali 15kg Rhizoma Smilacis Glabrae 110kg Radix Cyathulae 20kg Pseudobulbus Cremastrae Seu Pleiones 25kg
Fructus Arctii 20kg rhizoma sparganic 45kg Rhizoma Curcumae 8kg Radix Clematidis 42kg.
Medicinal 80% ethanol extraction of Radix Clematidis, Fructus Arctii, Radix Cyathulae three flavors 2 times, each 15 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Rhizoma Curcumae adopts steam distillation to extract volatile oil, and volatile oil device in addition stores for future use; Medicinal liquid device in addition stores for future use; Medicinal residues and Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, rhizoma sparganic four Chinese medicine, decoct with water 3 times, each 5 times of amounts, decoction 0.5 hour, above-mentioned medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50% precipitate with ethanol, left standstill 24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds the volatile oil that appropriate amount of auxiliary materials and Rhizoma Curcumae extract, and is prepared into pill behind the mix homogeneously.
Embodiment 12: capsule of the present invention
Radix Astragali 40kg Rhizoma Smilacis Glabrae 30kg Radix Cyathulae 45kg Pseudobulbus Cremastrae Seu Pleiones 8kg
Fructus Arctii 40kg rhizoma sparganic 8kg Rhizoma Curcumae 48kg Radix Clematidis 15kg.
Medicinal 50% ethanol extraction of Radix Clematidis, Fructus Arctii, Radix Cyathulae three flavors 3 times, each 3 times of amounts, medicinal liquid merges, and filters, and decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Rhizoma Curcumae adopts steam distillation to extract volatile oil, and volatile oil device in addition stores for future use; Medicinal liquid device in addition stores for future use; Medicinal residues and Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, rhizoma sparganic four Chinese medicine, decoct with water 2 times, each 15 times of amounts, decoction 2 hours, above-mentioned medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 80% precipitate with ethanol, left standstill 10 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste;
Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds the volatile oil that appropriate amount of auxiliary materials and Rhizoma Curcumae extract, and is prepared into capsule behind the mix homogeneously.
Claims (8)
1. Chinese medicine composition for the treatment of gout is characterized in that the crude drug of said composition consists of:
Radix Astragali 10-50 weight portion Rhizoma Smilacis Glabrae 20-120 weight portion Radix Cyathulae 10-50 weight portion
Pseudobulbus Cremastrae Seu Pleiones 5-30 weight portion Fructus Arctii 10-50 weight portion rhizoma sparganic 5-50 weight portion
Rhizoma Curcumae 5-50 weight portion Radix Clematidis 10-50 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:
The Radix Astragali 30 weight portion Rhizoma Smilacis Glabraes 70 weight portion Radix Cyathulaes 30 weight portions
Pseudobulbus Cremastrae Seu Pleiones 18 weight portion Fructus Arctiis 30 weight portion rhizoma sparganic 30 weight portions
Rhizoma Curcumae 30 weight portion Radix Clematidis 30 weight portions.
3. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:
The Radix Astragali 15 weight portion Rhizoma Smilacis Glabraes 110 weight portion Radix Cyathulaes 20 weight portions
Pseudobulbus Cremastrae Seu Pleiones 25 weight portion Fructus Arctiis 20 weight portion rhizoma sparganic 45 weight portions
Rhizoma Curcumae 8 weight portion Radix Clematidis 42 weight portions.
4. Chinese medicine composition as claimed in claim 1 is characterized in that the crude drug of said composition consists of:
The Radix Astragali 40 weight portion Rhizoma Smilacis Glabraes 30 weight portion Radix Cyathulaes 45 weight portions
Pseudobulbus Cremastrae Seu Pleiones 8 weight portion Fructus Arctiis 40 weight portion rhizoma sparganic 8 weight portions
Rhizoma Curcumae 48 weight portion Radix Clematidis 15 weight portions.
5. as described any one Chinese medicine composition of claim 1-4, it is characterized in that getting traditional Chinese medicinal composition raw materials, technology adds conventional adjuvant and is prepared into powder, capsule, tablet, granule, injection, oral liquid or drop pill routinely.
6. as the preparation method of described any one Chinese medicine composition of claim 1-4, it is characterized in that this method is:
Weighting raw materials decocts with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, medicinal liquid merges, filter, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, adds ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol, being concentrated into 50～60 ℃ of temperature relative densities is 1.10～1.25, drying gets dry extract; Dried cream powder is broken to be fine powder, adds conventional adjuvant and is prepared into granule, pill, capsule or tablet oral solid formulation.
7. as the preparation method of described any one Chinese medicine composition of claim 1-4, it is characterized in that this method is: medicinal 50～80% ethanol extractions of Radix Clematidis, Fructus Arctii, Radix Cyathulae three flavors 2～3 times, each 3～15 times of amounts, medicinal liquid merges, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Rhizoma Curcumae adopts steam distillation to extract volatile oil, and volatile oil device in addition stores for future use; Medicinal liquid device in addition stores for future use; Medicinal residues and Rhizoma Smilacis Glabrae, the Radix Astragali, Pseudobulbus cremastrae seu pleiones, rhizoma sparganic four Chinese medicine, decoct with water 2～3 times, each 5～15 times of amounts, decoction 0.5～2 hour, above-mentioned medicinal liquid merges, and filters, it is 1.05～1.15 that filtrate is concentrated into 50～60 ℃ of temperature relative densities, add ethanol to 50～80% precipitate with ethanol, left standstill 10～24 hours, filter, decompression filtrate recycling ethanol is concentrated into 50～60 ℃ of temperature relative densities and is 1.10～1.25 thick paste; Above thick paste merges, and drying gets dry extract; Dried cream powder is broken to be fine powder, adds the volatile oil that conventional adjuvant and Rhizoma Curcumae extract, and is prepared into granule, pill, capsule or tablet oral solid formulation behind the mix homogeneously.
8. as the application of described any one Chinese medicine composition of claim 1-4 in the medicine of preparation treatment gout.
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| CN2010101567355A Division CN101843848B (en) | 2006-10-13 | 2006-10-13 | Chinese medicinal composition for treating gout |
| CN2010101567548A Division CN101837093B (en) | 2006-10-13 | 2006-10-13 | Chinese medicinal composition for curing gout |
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| CN104138387A (en) * | 2014-07-24 | 2014-11-12 | 河南中医学院 | Application of arctiin to medicines for treating gout |
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| CN1500501A (en) * | 2002-11-12 | 2004-06-02 | 王红波 | Compound traditional Chinese medicine formulation for curing hysteromyoma |
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