CN101152088B - Noninvasive living body measuring device and noninvasive living body measuring method - Google Patents
Noninvasive living body measuring device and noninvasive living body measuring method Download PDFInfo
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- CN101152088B CN101152088B CN2007101513495A CN200710151349A CN101152088B CN 101152088 B CN101152088 B CN 101152088B CN 2007101513495 A CN2007101513495 A CN 2007101513495A CN 200710151349 A CN200710151349 A CN 200710151349A CN 101152088 B CN101152088 B CN 101152088B
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The present invention is to present a noninvasive living body measuring device that is capable of simplifying the structure and performing the analysis with accuracy in a short time. The noninvasive living body measuring device comprises: a light source for illuminating a living body which includes a blood vessel; an imaging part for imaging the illuminated living body to obtain a living body image; and an analyzing part for obtaining a density of a component contained in blood of the living body based on an image of the blood vessel in the living body image, and correcting the density of thecomponent based on an image of a peripheral tissue of the blood vessel in the living body image.
Description
Technical field:
The present invention relates to a kind of noinvasive biometric apparatus and noinvasive bioassay method of contained composition in the blood being measured by the blood vessel of analyzing in the shooting organism gained organism image.
Background technology:
With photographic equipment take organism, analyze blood vessel in the biometric image, the noinvasive biometric apparatus of measuring blood components such as hemoglobin with this has been open such as disclosing on the 2004-162471 communique at U. S. application.This U. S. application discloses the light harvesting equipment of first light source that the device of recording and narrating on the 2004-162471 communique possesses the blood vessel (vein) on the irradiation user wrist, the blood vessel detection optical information under first light source irradiation, according to the analytical equipment of the blood component of this optical information analysis stream through above-mentioned blood vessel.With this, user can only be worn over said apparatus can the contained composition of continuous measurement blood on the wrist.
When disclosing the device mensuration blood component of recording and narrating on the 2004-162471 communique with U. S. application, for the ease of taking blood-vessel image, band is worn over the position of user arm than the close heart of wrist, apply certain pressure to this user arm, hinder wrist blood flow on every side with this, wrist blood vessel (vein) is expanded.
Organism is because the exerting pressure of band, target blood not only, and the blood capillary of this blood vessel surrounding tissue is congestion also, and blood remains in a standstill.According to containing blood vessel poor in the brightness of the brightness of the photographic images medium vessels of interior organism part and its peripheral part, ask the amount of blood component during mensuration.But surrounding tissue pressurized congestion, above-mentioned luminance difference can be dwindled.Therefore, the measured value problem littler than actual value arranged.
U. S. application discloses the device recorded and narrated on the 2004-162471 communique outside above-mentioned first light source, also dispose the secondary light source of irradiation blood vessel surrounding tissue in addition, from the second light harvesting part of the biological cell detection optical information of being shone by secondary light source, according to the optical information of obtaining from biological tissue blood component is proofreaied and correct.
Yet, U. S. application discloses the device recorded and narrated on the 2004-162471 communique except being used for from original determination object---and blood vessel obtains the device of optical information, also need to be used for obtaining from circumvascular biological tissue the special light source and the light harvesting device of optical information, the structure of device is very complicated.Owing to obtaining, can not take pictures for biology when analyzing above-mentioned optical information, the analysis of blood component is very time-consuming again.
U. S. application discloses the device of recording and narrating on the 2004-162471 communique and also is furnished with the 3rd light source with the luminous irradiation blood vessel of the same direction of first light source, and above-mentioned light harvesting device is from the blood vessel detection optical information of first light source and the 3rd light source irradiation.That is, to disclose the device of recording and narrating on the 2004-162471 communique be reflection-type device at biological side configuration light source and picture pick-up device to U. S. application.This reflection-type device can not be configured in light source in the visual field of picture pick-up device, so the brightness in the picture pick-up device visual field does not have transmissive device even.The luminous quantity of first light source and the 3rd light source has significant impact to measuring precision, and therefore, in the noinvasive biometric apparatus of reflection-type, the light quantity of first light source and the 3rd light source is regulated very important.
Summary of the invention:
First of the present invention provides a kind of noinvasive organism determinator, comprising:
Light source, illumination contains blood vessel at interior organism;
Camera system is taken the described organism that shines; And
Analytical system looks like to obtain contained components and concentration in the blood, according to the blood vessel perienchyma picture in the described organism image described gained components and concentration is proofreaied and correct according to the blood vessel of taking in the gained organism image.
Wherein:
Described analytical system has the first generation equipment, the second generation equipment, components and concentration and obtains equipment and calibration equipment, and the first generation equipment is used for generating according to described biometric image the first Luminance Distribution information of first Luminance Distribution that the cross-section described organism image medium vessels picture of expression distributes; The second generation equipment is used for generating the second Luminance Distribution information of expression along second Luminance Distribution of described organism image medium vessels picture distribution according to described biometric image; Components and concentration obtains equipment and is used for obtaining described components and concentration according to the described first Luminance Distribution information; Calibration equipment is used for according to the described second Luminance Distribution information this components and concentration being proofreaied and correct.
The described second generation equipment can generate the described second Luminance Distribution information according to being arranged in the blood vessel perienchyma picture of the described biometric image medium vessels of distance as the described biometric image of certain distance.
Described calibration equipment can obtain the value of the blood volume in the reflection blood vessel perienchyma according to the described second Luminance Distribution information, and according to the value of described acquisition described components and concentration is proofreaied and correct.
Described calibration equipment can obtain the attenuation rate that the brightness on described second Luminance Distribution decays with the distance apart from described light source according to the value of the blood volume in the described reflection blood vessel perienchyma.
Second portion of the present invention provides a kind of noinvasive organism determinator, comprising:
Light source, illumination contains blood vessel at interior organism;
Camera system is taken the described organism that shines; And
Analytical system is according to taking the blood vessel picture in the gained biometric image and reflecting that the value of blood volume in the blood vessel perienchyma obtains the contained components and concentration of blood.
Wherein:
The value of blood volume is the attenuation rate that the brightness of blood vessel perienchyma picture decays with the distance apart from described light source in the described reflection blood vessel perienchyma.
Third part of the present invention provides a kind of noinvasive organism determinator, comprising:
First light source, illumination contains blood vessel at interior organism;
Secondary light source, with described first light source keep at a certain distance away configuration, described organism throws light on;
Camera system is taken described organism;
Analytical system looks like to obtain contained components and concentration in the blood by analyzing the blood vessel that described camera system takes in the described organism gained organism image; And
Win organism image and described camera system of light modulation equipment, the described organism of taking described first light source irradiation according to described camera system taken described first light source of the described organism gained second organism image adjustment of described secondary light source irradiation and each light quantity of secondary light source.
Wherein:
Described camera system can obtain three lives subject image by taking the described organism of described first light source and secondary light source irradiation;
Described analytical system can be analyzed the blood vessel picture in the described three lives subject image.
Described noinvasive organism determinator also comprises the part of accepting of indication that accept to measure indication, wherein, when described noinvasive organism determinator is accepted partly to receive that described mensuration is indicated when its indication, described light modulation equipment is regulated the light quantity of described first light source and secondary light source, described first light source and secondary light source after the light modulation shine described organism, described camera system is taken the described organism under described first light source and secondary light source irradiation, and the blood vessel that described analytical system is taken in the three lives subject image that described organism obtains this camera system looks like to analyze.
Described light modulation equipment can generate the first Luminance Distribution information of first Luminance Distribution of representing the cross-section described first biometric image medium vessels picture and distributing, the second Luminance Distribution information of second Luminance Distribution that generates the cross-section described second organism image medium vessels picture of expression and distribute, the light quantity of regulating described first light source and secondary light source according to the described first Luminance Distribution information and the second Luminance Distribution information.
The light quantity that described light modulation equipment can be regulated described first light source and secondary light source according to maximum brightness value in maximum brightness value in described first Luminance Distribution and described second Luminance Distribution.
The shooting district of described camera system has along first central shaft of described organism blood vessel setting and second central shaft that intersects vertically with described first central shaft,
Described first light source and secondary light source press from both sides described first central shaft arrangement.
When described first light source and secondary light source pressed from both sides described first central shaft arrangement, standoff distance was shorter than the shooting section length of the axial length direction of described second central shaft.
Described first light source comprises two light source devices,
Described secondary light source comprises two light source devices,
Two light source devices that described first light source is possessed press from both sides described shooting district and the described first central shaft axial length direction configured in parallel,
Two light source devices that described secondary light source possessed press from both sides described shooting district and the described first central shaft axial length direction configured in parallel.
The present invention's the 4th part provides a kind of noinvasive organism assay method, comprising:
For containing the step of blood vessel in interior organism illumination;
Take described illumination organism, obtain the step of organism image;
The step that looks like to obtain the contained components and concentration of blood according to the blood vessel in the described organism image; And
According to described organism image medium vessels perienchyma picture the described components and concentration of obtaining is carried out gauged step.
The present invention's the 5th part provides a kind of noinvasive organism assay method, comprising:
Contain blood vessel at interior organism with first light source irradiation;
Take the organism of described first light source irradiation, obtain the first organism image;
Shine described organism with secondary light source;
Take the described organism of secondary light source irradiation, obtain the second organism image;
Light quantity according to the described first organism image and described first light source of the second organism image adjustment and secondary light source;
Shine described organism with described first light source and secondary light source after the light modulation;
Take the described organism of described first light source and secondary light source irradiation, obtain three lives subject image; And
Analyze the blood vessel picture in the described three lives subject image.
Description of drawings:
Fig. 1 is the general configuration figure of an embodiment of demonstration noinvasive biometric apparatus of the present invention;
Fig. 2 is the cross-sectional illustration figure of noinvasive biometric apparatus shown in Figure 1;
Fig. 3 is the plane graph of light-source structure;
Fig. 4 is the location diagram that is located at the light emitting diode on the fixing head;
Fig. 5 is the structured flowchart of determination unit;
Picture one example when Fig. 6 is in holding state for the noinvasive biometric apparatus;
Picture displayed one example when Fig. 7 is the para-position of noinvasive biometric apparatus blood vessel;
Picture one example when Fig. 8 measures end for the noinvasive biometric apparatus;
Fig. 9 is the flow chart of noinvasive biometric apparatus measurement operation;
Figure 10 is divided into the accompanying drawing of X, Y two-dimensional coordinate in 0≤x≤640,0≤y≤480 scopes for the rectangular region that will contain camera watch region CR;
Figure 11 is brightness waveform (brightness waveform PF) example of the directions X pixel in certain Y coordinate;
Figure 12 is a key diagram of asking the vessel position method;
Figure 13 measures the detail flowchart of handling for the hemoglobin concentration of implementing among the flow chart step S11 shown in Figure 9;
Figure 14 is the scattergram with respect to position X concentration D;
Figure 15 is the scattergram for position X brightness B;
Figure 16 is the scattergram with respect to position X solution D;
Figure 17 is the illustration figure along second Luminance Distribution of blood vessel picture distribution; And
Figure 18 is the measured value that will record with blood-counter system etc. at several examinees' hemoglobin concentration and the figure that is depicted as with the value that the noinvasive organism determinator 1 of embodiment of the present invention calculates.
The specific embodiment:
Describe the embodiment of noinvasive biometric apparatus of the present invention with reference to the accompanying drawings in detail.
Fig. 1 is the general configuration figure of an embodiment of demonstration noinvasive biometric apparatus 1 of the present invention.This noinvasive biometric apparatus 1 is a watch style blood analysis of components instrument, is made up of instrument host 3 and fixer 4.Instrument host 3 is worn on people's wrist by fixer 4.Instrument host 3 can rotate along people's wrist by fixer 4 and adjust the position.The side of instrument host 3 is provided with power supply/execute key 38 and the entree singly-bound 39 for user operation noinvasive biometric apparatus 1.Band 2 is worn over the user arm than the more close heart of wrist place.Band 2 is exerted pressure to the user arm with certain pressure, stops wrist blood flow on every side, and the blood vessel (vein) of wrist is expanded.So under the state of wrist pressurization, measure, be easy to the shooting of blood-vessel image at band 2.
Fig. 2 is the cross-sectional illustration figure of noinvasive biometric apparatus 1 shown in Figure 1.Instrument host 3 is made up of shell 35, the inner cap 37 that is disposed at shell 35 inboards, the conjunction 41 that is contained in inner cap 37 bottoms.Shell 35 central promising placement aftermentioned determination units 5 and the cylindrical shape unit fixed part 35a that forms.The central authorities of inner cap 37 and conjunction 41 form a space, are used for accomodating unit fixed part 35a.Stretch out pair of protrusions 35c, 35d from the outer wall by-level of this element fixed part 35a.Connect with compression spring 37a, 37b respectively between this outthrust 35c and the inner cap 37 and between outthrust 35d and the inner cap 37.Shell 35 is exerted pressure to inner cap 37 by these compression springs 37a, 37b.The side of conjunction 41 forms concavity joint portion 41a, can with the negative protrusion 42a interlock of aftermentioned support 42.
Said fixing utensil 4 is made of support 42 and wrist strap 43.Support 42 upper shapes are rectangle, and there is the circular open for the conjunction 41 that embeds instrument host 3 in its central authorities.The edge of this opening is provided with conjunction 41 can be along the negative protrusion 42a of axle AZ rotation.Support 42 is equipped with retractile rubber system wrist strap 43.Shell 35 and the lighttight material of inner cap 37 usefulness are made.
Unit fixed part 35a is fixed with determination unit 5.This determination unit 5 is made up of light source 51, camera system 52, controller 53, display 54, is connected with electric wire and flat cable (not having diagram) etc. between light source 51, camera system 52, display 54 and the controller 53, mutually the transmission electronic signal.
Describe with regard to light source 51 below.Fig. 3 is the plane structure chart of light source 51.Light source 51 is made of disc fixing head 51a, four light emitting diode R1, R2, L1, L2 being fixed in this fixing head 51a.There is the circular open 51b that passes through for the light of injecting camera system 52 in the central authorities of fixing head 51a, have disposed above-mentioned light emitting diode around this opening 51b.
Fig. 4 is the location diagram that is disposed at four light emitting diodes of fixing head 51a.Light emitting diode R1, R2, L1, L2 are disposed at respectively symmetrically by on orthogonal crossing first AY in opening 51b center and second AX.Wear under the state of wrist at noinvasive biometric apparatus 1, the shooting district CR on wrist surface is for being taken and be presented at the zone of display 54 by shooting system 52.Regional 62c between the markings 62b of the markings 62a of light emitting diode L1, L2 (secondary light source) side and light emitting diode R1, R2 (first a light source) side for be suitable for camera system 52 shooting areas, the residing band of position of blood vessel when promptly making a video recording.Markings 62a and 62b are presented at display 54 by controller 53.When carrying out the blood component analysis, adjust the installation site of instrument host 3, make any vessels of wrist be positioned at above-mentioned zone 62c.Blood vessel by light emitting diode R1, R2, L1, L2 from both sides with near infrared light (centre wavelength=805nm) illuminate.
Structure with regard to camera system 52 describes below.As shown in Figure 2, camera system 52 focuses on the lens barrel 52b with camera lens 52a, fixed lens 52a, the CCD photographing unit 52c of shooting organism by reflected light and constitutes, and can take shooting district CR.It is the columnar cone 52d of black that camera lens 52a and lens barrel 52b insert inside.CCD photographing unit 52c arrives controller 53 with the image of imaging with image signal transmission.
The following describes the structure of controller 53.Controller 53 is on CCD photographing unit 52c.Fig. 5 is the structured flowchart of determination unit 5.Controller 53 is made of CPU53a, main storage 53b, flash card reader 53c, light source input and output interfaces 53d, frame memory 53e, image input interface 53f, input interface 53g, communication interface 53h, image output interface 53i.CPU53a, main storage 53b, flash card reader 53c, light source input and output interfaces 53d, frame memory 53e, image input interface 53f, input interface 53g, communication interface 53h, image output interface 53i connect by data line, can pass data mutually.This structure can read and write data CPU53a to main storage 53b, flash card reader 53c and frame memory 53e, and passes data mutually with light source input and output interfaces 53d, image input interface 53f, input interface 53g, image output interface 53i and communication interface 53h.
CPU53a as analytical system can carry out the computer program that is stored in no illustrated ROM and main storage 53b.This device is exactly to carry out the aftermentioned computer program by this CPU53a, performance noinvasive biometric apparatus function.
The analog signal interface that light source input and output interfaces 53d is made up of D/A converter and A/D converter etc. constitutes.Light source input and output interfaces 53d is connected with electrical signal line with four light emitting diode R1, R2, L1, L2 being located at light source 51 respectively, can control the action of these light emitting diodes.Light source input and output interfaces 53d controls electric current to light emitting diode R1, R2, L1, L2 according to the aftermentioned computer program.
The analog signal interface that input interface 53g is made up of A/D converter constitutes, and power supply/execute key 38 and entree singly-bound 39 are electrically connected with it.User can be by the operation item of these entree singly-bound 39 selecting arrangements.Can also allow the electric power on/off and the selected operational motion of device actuating unit by power supply/execute key 38.
Image output interface 53i and display 54 are electrically connected, and will output to display 54 with the view data image signals corresponding that receives from CPU53 a.
Describe with regard to display 54 below.As shown in Figure 2, display 54 is disposed at determination unit 5 tops, is fixed on the shell 35.This display 54 is made of liquid crystal display, according to the picture signal display frame that receives from image output interface 53i.This picture shows and can switch according to the state of noinvasive biometric apparatus 1, such as with holding state, blood vessel para-position the time, measure the corresponding picture of done state and be presented on the display 54.
Fig. 6 has shown an example of display frame when noinvasive biometric apparatus 1 is in holding state.The picture central authorities of display 54 showed date and the time when noinvasive biometric apparatus 1 was in holding state.The picture lower right of display 54 is menu viewing area 54a, shows the action of the noinvasive biometric apparatus 1 when press power supply/execute key 38, when being in holding state, and demonstration " mensuration ".
One example of display frame when Fig. 7 is the blood vessel para-position.The noinvasive biometric apparatus 1 of present embodiment can show that expression be suitable for markings 62a, the 62b in the zone that camera system 52 takes at display 54, judges that simultaneously blood-vessel image is whether in the zone that is suitable for making a video recording.When carrying out the blood vessel para-position, show vascular graphic 61 that the aftermentioned mode forms and with markings 62a, the 62b of red display with the bat image.The labelling 63,64,65,66 that shows the expression direction around these markings 62a, the 62b.Each labelling can bright lamp, and during position in vascular graphic 61 can not be accommodated in regional 62c between markings 62a and the markings 62b, controller 53 makes each labelling shinny, and the indication user moves the direction of instrument host 3, makes vascular graphic 61 be positioned at regional 62c.
At this, move with regard to the bright lamp indicating instrument of each labelling main frame 3 and to carry out simple declaration.In Fig. 7, when labelling 63 and labelling 64 were bright, user need move instrument host 3 in the right side in Fig. 7, when labelling 65 and labelling 66 are bright, user need be in Fig. 7 the mobile instrument host 3 in left side.When labelling 63 and labelling 65 were bright, user need clockwise rotate instrument host 3, and when labelling 64 and labelling 66 were bright, user need rotate counterclockwise instrument host 3.As shown in Figure 7 the time, controller 53 bright labelling 63 and labellings 65 urge user to clockwise rotate instrument host 3 such as, vascular graphic 61 positions.By this structure, the position of camera system 52 to be adjusted to when being suitable for taking blood vessel regional, user is easy to grasp this which side moves instrument host 3 to, is convenient to adjust the position of camera system 52.
In addition, if vascular graphic 61 not in regional 62c (Fig. 4), then markings 62a, 62b are shown in red, if vascular graphic 61 in regional 62c, then markings 62a, 62b are shown as blueness.In view of the above, user can know very like a cork that vascular graphic 61 is not or not in the regional 62c.
When carrying out the blood vessel para-position, menu viewing area 54a shows " continuation ", and when vascular graphic 61 was positioned at regional 62c, markings 62a, 62b were shown as blueness, and power supply/execute key 38 is effective, and user is then measured and proceeded by this key.
Fig. 8 is picture one example that noinvasive biometric apparatus 1 is measured when finishing.The measurement result of blood component hemoglobin concentration with digital form, be convenient to the mode that user checks and be presented on the display 54, be shown as " 15.6g/dL ".At this moment, menu viewing area 54a shows " affirmation ".
Mensuration process with regard to noinvasive biometric apparatus 1 describes below.Fig. 9 is the flow chart that noinvasive biometric apparatus 1 is carried out measurement operation.At first, as shown in Figure 1, band 2 is tied to the user arm, and noinvasive biometric apparatus 1 is worn in wrist.At this moment, the user arm is applied certain pressure by band 2, and the blood flow around the wrist is obstructed, and the blood vessel of wrist expands.Then, user is pressed the power supply/execute key 38 on the noinvasive biometric apparatus 1, and the initialization of software is then carried out in 1 one energisings of noinvasive biometric apparatus, simultaneously, checks each position state (step S1).Subsequently, device is in holding state, and holding state picture shown in Figure 6 is presented at display 54 (step S2).
When the holding state picture was presented on the display 54, user was by power supply/execute key 38 (S3 selects "Yes" in step), and then para-position picture shown in Figure 7 (step S4) appears in display 54.At this moment, CPU53a allows light emitting diode R1, the R2, L1, the L2 that are disposed at light source 51 luminous respectively with certain light quantity, irradiation shooting district CR (Fig. 4), and shooting district CR (step S5) is shone in shooting.
Figure 10 is divided into the accompanying drawing of X, Y two-dimensional coordinate in 0≤x≤640,0≤y≤480 scopes for the rectangular region that will comprise shooting district CR.CPU53a as shown in figure 10, coordinate with the upper left pixel of the rectangular region A that comprises shooting district CR image is (0,0), regional A is divided into X, Y two-dimensional coordinate with coordinate, from the point that coordinate is cut apart, selects (240,60), (400,60), (240,420), (400,420) 4 points.CPU53a asks these 4 mean flow rates (step S6) that cross area B.The coordinate of determining area B is not limited thereto, and other coordinates also can.In addition, area B also can be polygon or the circle beyond the quadrangle.
Next, CPU53a judges that the brightness of area B is whether in target zone (step S7).If the brightness of area B outside target zone, is then adjusted the magnitude of current that flows into light emitting diode R1, R2, L1, L2 by light source input and output interfaces 53d, carry out light quantity and regulate (step S8), and return step S1.If the brightness of area B (is selected "Yes" at step S7) in target zone, then CPU53a is set at initial value (40) (step S9) with the Y coordinate figure of the calculating object of aftermentioned brightness waveform.Ask the pixel intensity of the X coordinate end to end on set Y coordinate figure (40).As shown in figure 11, can obtain the pixel intensity waveform (brightness waveform PF) (step S10) of the directions X on certain Y coordinate with this.CPU53a judges whether set Y coordinate figure is final value (440) (step S11).If the Y coordinate is not a final value (440) (S11 selects "No" in step), then CPU53a is to Y coordinate figure increment certain value (20) (step S12), and processing is turned back to step S10.If the Y coordinate is a final value (440) (S11 selects "Yes" in step), then CPU53a extracts the minimum point (to call " brightness minimum point " in the following text) of brightness in each brightness waveform that extracts, and stores frame memory 53e (step S13) into.
Figure 12 is a key diagram of asking the method for vessel position.Promptly, as shown in figure 12, CPU53a will make a video recording and distinguish near the brightness minimum point of CR picture centre (a1, b1) difference brightness minimum point therewith (a1, b1) vertical adjacent brightness minimum point (a2, b2) reach (a3, b3) connect, (a2 b2) is connected with vertical adjacent point with the brightness minimum point again, (a3 b3) is connected with vertical adjacent some the brightness minimum point.CPU53a carries out this operation repeatedly in entire image, until blood vessel is come out as line extraction, form vascular graphic 61 (step S14).CPU53a shows the image of the shooting district CR that takes as shown in Figure 7 on display 54, and vascular graphic 61, the markings 62a that is stored in flash card 53j and markings 62b (Fig. 4), labelling 63,64,65 and 66 (the step S15) of step display S5 formation.CPU53a judges whether vascular graphic 61 is positioned at regional 62c (Fig. 4) (step S16).If vascular graphic 61 is not positioned at regional 62c (S16 selects "No" in step), CPU53a bright labelling 63,64,65 and 66 respectively then, the direction that indicating instrument main frame 3 should move (step S17), and processing returned step S1.
If vascular graphic 61 is positioned at regional 62c (S16 selects "Yes" in step), it is effective that then CPU53a makes power supply/execute key 38, can continue to measure.At this moment, CPU53a ring sound notice user power supply/execute key 38 effective (step S18).Then, CPU53a waits for the input (step S19) from power supply/execute key 38.User is pressed power supply/execute key 38, and indication continues to measure (S19 selects "Yes" in step), and then CPU53a carries out the mensuration (step S20) of hemoglobin concentration, as shown in Figure 8 measurement result is presented at display 54 (step S21).
Figure 13 is the detail flowchart of handling at the hemoglobin concentration that the step S20 of flow chart shown in Figure 9 implements.At first, CPU53a control light source input and output interfaces 53d, light emitting diode R1, the R2 (first light source) that are disposed at a sidelight source in the light source of both sides with the folder blood vessel shine with suitable light quantity and contain blood vessel at interior organism (step S101), with camera system 52 take pictures (step S102).Next, CPU53a judges whether the mean flow rate of area B surpasses 100 (step S103).If brightness does not surpass 100, then CPU53a adjusts the magnitude of current that flows to light emitting diode R1, R2 with light source input and output interfaces 53d, regulates the light quantity (step S104) of light emitting diode R1, R2, returns step S102 afterwards.
The digital translation value (changing) of 8 bit pads that the image input interface 53f that refers to use in the present embodiment in the value of this said brightness is had from 0～255.The size of the picture signal of the brightness of image and CCD photographing unit 52c input is directly proportional, and therefore, is brightness value with the A/D conversion value (0～255) of picture signal.
When the mean flow rate of area B surpassed 100 (S103 selects "Yes" in step), CPU53a obtained the brightness waveform PF1 of relevant step S102 gained image and does not rely on the concentration waveform NP1 (step S105) that injects light quantity.CPU53a also controls light source input and output interfaces 53d, light emitting diode L1, the L2 (secondary light source) that are disposed at opposite side light source in the light source of both sides with the folder blood vessel shine with suitable light quantity and contain blood vessel at interior organism (step S106), with camera system 52 take pictures (step S107).Then, CPU53a judges whether the mean flow rate of area B surpasses 100 (step S108).If brightness does not surpass 100, then CPU53a adjusts the magnitude of current that flows to light emitting diode L1, L2 with light source input and output interfaces 53d, regulates the light quantity (step S109) of light emitting diode L1, L2, returns step S107 afterwards.
When the mean flow rate of area B surpassed 100 (S108 selects "Yes" in step), CPU53a carried out the same processing with step S105 for step S107 gained image, obtained brightness waveform PF2 and did not rely on the concentration waveform NP2 (step S110) that injects light quantity.
Figure 15 is the scattergram of the brightness B of correspondence position X, and brightness waveform PF1 forms by step S105, and brightness waveform PF2 forms by step S110.Figure 16 is the scattergram of the concentration D of correspondence position X, and concentration waveform NP1 forms by step S105, and concentration waveform NP2 forms by step S110.
CPU53a obtains peak height h1 and barycentric coodinates cg1 from the concentration waveform NP1 that step S105 obtains respectively, the concentration waveform NP2 that obtains from step S110 obtains peak height h2 and barycentric coodinates cg2, and with these values of obtaining, calculate blood vessel depth index S by following formula (1), store result of calculation into frame memory 53e (step S111).
S＝(cg2-cg1)/{(h1+h2)/2}……(1)
CPU53a calculates the light amount ratio and the luminous quantity (step S112) of the light source (light emitting diode R1, R2 and light emitting diode L1, L2) about blood vessel respectively according to the brightness waveform PF1 of step S105 acquisition and the brightness waveform PF2 of step S110 acquisition.CPU53a regulates the luminous quantity (step S113) of two light sources according to gained result of calculation.
Particularly, brightness waveform (with reference to Figure 15) in the bright lamp of bright lamp image in right side (step S102) and left side (the bright lamp of light emitting diode L1, L2) [secondary light source] gained bright lamp image in left side (step S106) generation that obtains according to the bright lamp in right side (the bright lamp of light emitting diode R1, R2) [first light source], high-high brightness position with left-half is x1, is x2 with right half part high-high brightness position.The brightness value of establishing the x1 position on the brightness waveform PF2 when the bright lamp in left side is L1, and the brightness value of x2 position is L2, and on the brightness waveform PF1 when the bright lamp in right side, the brightness value of establishing the x1 position is R
1, the brightness value of x2 position is R
2
If the current value of left and right sides light source is expressed as current value=(left and right), current value=(a C left side, 0) during left side bright lamp, current value during right side bright lamp=(0, the C right side), then the Luminance Distribution when making the bright lamp in both sides is that source current that level (evenly) is carried out distributes can be by a left side: the right side=x: the electric current when ratio (1-x) distributes one-sided bright lamp.That is current value=(an xC left side, (1-x) C right side) during the bright lamp in both sides.
If x=-(R
1-R
2)/{ (L
1-L
2)-(R
1-R
2), then with the L that as above stipulates
1, L
2, R
1And R
2Value, can obtain x.Such as, if current value=(18,0), the current value the when right side is bright=(0,16), x=0.4375 when the left side is bright, the current value when then both sides are bright=(18 * 0.4375,16 * 0.4375)
(8,9).So, the light quantity that can regulate two light sources is calculated the CR (step S114) with the shooting district, illumination shooting district CR equably to take hemoglobin concentration.
CPU53a control light source input and output interfaces 53d, with light emitting diode R1, R2, L1 and L2 through light modulation is shooting district CR illumination, with camera system 52 take pictures (step S114), the same with step S6 then, ask the mean flow rate of area B shown in Figure 10, judge whether the mean flow rate of the area B of asking surpasses 150 (step S115).If do not surpass 150, then show wrong (step S116).
The mean flow rate of area B is as surpassing 150 (S115 selects "Yes" in step), then CPU53a draws expression corresponding to the brightness waveform of first Luminance Distribution of shooting district CR (Fig. 4) axis AX (to the distribution of the brightness B of position X) PF (Figure 11), reduces noise component with the fast Fourier transform (FFT) scheduling algorithm.CPU53a also formats this brightness waveform PF with datum line BL.This datum line BL is that try to achieve on the basis with the brightness waveform of blood vessel absorption portion.Like this, just can obtain not relying on the concentration waveform of injecting light quantity (with respect to the distribution of the concentration D of position X) NP (step S117).
Figure 14 is the scattergram with respect to the concentration D of position X, and the concentration waveform NP of formation promptly as shown in the figure.Then, CPU53a calculates peak height h and half value fabric width w according to the concentration waveform NP that forms.Represent the light intensity by survey blood vessel (blood) and the ratio of the light intensity by tissue part at this gained h, i.e. the degree of the light intensity that absorbs of blood vessel; W represents to be equivalent to the length of blood vessel diameter.CPU53a also uses following formula (2) to calculate and does not revise hemoglobin concentration D, and the result is stored in frame memory 53e (step S118).
D＝h/w
n……(2)
Wherein, the non-linear constant widened for the half value width of cloth that brings of expression light scattering of n.During no light scattering, n=1, when light scattering is arranged, n＞1.
Next, CPU53a analyzes the tissue picture (step S119) around step S114 gained biometric image medium vessels, and that calculates contained blood volume in this perienchyma of expression organizes blood volume index M (step S120).Particularly, according to being arranged in, extract the Luminance Distribution that distributes along this blood vessel picture apart from the blood vessel of biometric image blood vessel perienchyma picture as this biometric image of certain distance (for example 2.5mm).Not only taking in the biometric image has the purpose blood vessel, also has this circumvascular tissue.Brightness in the image also is exponential function decay, the ratio of brightness decay and the proportional variation of the blood volume in the cell with light source to the distance of irradiation position.Therefore, as long as calculate the brightness decay rate of perivascular cells picture, can extrapolate the blood volume in the perienchyma.
Blood vessel in photographic images, be arranged in slightly by middle, like with middle body is vertical be truncated into about on the position of (about Fig. 3～4 are) two-stage nitration.Therefore, can use in the calculating of above-mentioned attenuation rate parallel with this blood vessel, apart from blood vessel only on the straight line of certain distance (as markings 62a or 62b among Fig. 4) or along collinear Luminance Distribution (also claiming second Luminance Distribution) (following Luminance Distribution (first Luminance Distribution)) corresponding to transversal blood vessel.
Suppose that blood vessel perienchyma is average substantially, though then the light that sends of light source is the exponential function decay with the distance of distance light source, but because as the light emitting diode of light source be disposed at shooting district CR about (about in Fig. 3～4 being), so above-mentioned second Luminance Distribution is reciprocal parabolic shape to the exponential function coincidence.Figure 17 is the displayed map along the second Luminance Distribution example of blood vessel picture distribution.The longitudinal axis is brightness in Figure 17, and transverse axis is the position of shooting district inner rim tissue along the blood vessel picture.Such as, be example with second Luminance Distribution of measuring on the markings 62b (with reference to Fig. 4), d1 on the transverse axis and d2 correspond essentially to above-mentioned markings 62b and distinguish cross point d1 and the d2 of CR with circular the shooting as shown in Figure 4.
In Figure 17, parabolic curve m represents the brightness of actual measurement, and exponential function n and exponential function o represent the exponential function that this curve m is divided into two with the aftermentioned method.Parabolic curve p is the figure that forms of the above-mentioned exponential function n of superposition and exponential function o in theory, shows consistent with actual measured value.
Parabolic curve m to be divided into two exponential function n and exponential function o, at first will cast out the part that there is saturated sense at two ends among the parabolic curve m, only stay and in fact to be considered as parabolical part.If the left end brightness of the part of staying is that the brightness of y0, minimum mid portion is y1.If each pixel of adjacent pixels brightness is (r * 100) %, this r is defined as attenuation rate.
So, at the above-mentioned left end that stays part, the light that top light emitting diode R1 sends is 100%, the light decay that below light emitting diode R2 sends is kept to the w power of attenuation rate r, therefore, the initial value D0 of the initial value U0 of top light emitting diode R1 and below light emitting diode R2 can be respectively with following formula (3), (4) expression.
U0＝y0/(1+r
w)……(3)
D0＝y0/(1+r
w)……(4)
At mid portion, the light that sends of light emitting diode all decays to the w/2 power of r up and down, and therefore following formula (5) is set up.
y1＝2×U0×r
w/2
＝2×y0/(1+r
w)×r
w/2……(5)
Separate formula (5) with regard to r, can obtain attenuation rate r.If r
W/2=X then,
If disclose the described traditional method of 2004-162471 communique, need optical sensor with far and near two special light sources and this source light of detection with U. S. application.And, be v1 if establish the nearside light source projects to the light quantity of optical sensor, the distally light source projects is v2 to the light quantity of optical sensor, then uses M=log (v1/v2) to ask the above-mentioned blood volume index M that organizes.
At this, the definition of attenuation rate r is that each pixel of neighbor brightness is (r * 100) %.Be Ln if establish nearside light source in the above-mentioned traditional method to the distance (pixel unit) of optical sensor, the distally light source is Lf to the distance (pixel unit) of optical sensor, and then about the nearside light source, brightness decay is that r multiply by Ln, about the distally light source, brightness decay is the Lf power of r.Therefore learn,
M=log (C * r
Ln)/(C * r
Lf), can replace above-mentioned v1, v2 with attenuation rate r and calculate and organize the same value of blood volume index M.C is the early stage light value (the not light value of decaying because of tissue) of above-mentioned nearside light source or distally light source.
CPU53a obtains correction coefficient fs according to the blood vessel depth index S that step S111 calculates, and the blood volume index M that organizes that calculates according to step S120 obtains correction coefficient fm.With these values of obtaining, calculate the correction hemoglobin concentration Do (step S121) that forms by following formula (6).
Do＝D×fs×fm……(6)
CPU53a deposits the result of calculation of step S121 in frame memory 53e (step S122), returns mastery routine.
Figure 18 is the hemoglobin concentration at several examinees, measured value that will record with blood-counter system etc. and the figure that is depicted as with the value that the noinvasive organism determinator 1 of embodiment of the present invention calculates.As shown in figure 18, the value that measured value and noinvasive organism determinator 1 calculate all is positioned near the straight line of inclination, measured value and the value of calculating zero difference, and hence one can see that, and noinvasive organism determinator 1 can accurately be measured hemoglobin concentration.
Present embodiment as mentioned above, according to the bright lamp image in right side of the bright lamp in right side (light emitting diode R1, R2 are bright) gained and the bright lamp image in left side of the bright lamp in left side (light emitting diode L1, L2 are bright) gained, regulate the light quantity of two light sources (first light source and secondary light source), so that obtain hemoglobin concentration calculating photographic images.Light right side light emitting diode R1, R2 (first light source) and light emitting diode L1, L2 (secondary light source) so respectively and take, in the time of can obtaining to reflect the bright lamp in right side during the bright lamp in the bright lamp image in right side (first biometric image) of shooting district CR brightness and reflection left side shooting distinguish the bright lamp image in left side (second biometric image) of CR brightness.Can understand of the influence of each light source light quantity from these biometric images, know each dimming light source can make shooting district CR brightness even to which kind of degree shooting district CR brightness.Therefore, the light quantity of using the bright lamp image of bright lamp image in above-mentioned right side and left side can regulate two light sources obtains the light quantity that is suitable for taking.
Claims (4)
1. noinvasive organism determinator comprises:
Light source, illumination contains blood vessel at interior organism;
Camera system is taken the described organism that shines; And
Analytical system, have the first generation equipment, the second generation equipment, hemoglobin concentration and obtain equipment and calibration equipment, the described first generation equipment is used for generating according to biometric image the first Luminance Distribution information of first Luminance Distribution that the blood vessel picture of the described biometric image of the cross-section shooting gained of expression distributes; The described second generation equipment is used for generating the second Luminance Distribution information of expression along second Luminance Distribution of the blood vessel picture distribution of described biometric image according to being arranged in the blood vessel perienchyma picture of the described biometric image medium vessels of distance as the described biometric image of certain distance; Described hemoglobin concentration is obtained equipment and is used for obtaining hemoglobin concentration according to the described first Luminance Distribution information; Described calibration equipment is used for according to the described second Luminance Distribution information described hemoglobin concentration being proofreaied and correct.
2. according to the described noinvasive organism of claim 1 determinator, it is characterized in that:
Described calibration equipment can obtain the value of the blood volume in the reflection blood vessel perienchyma according to the described second Luminance Distribution information, and according to the value of described acquisition described hemoglobin concentration is proofreaied and correct.
3. according to the described noinvasive organism of claim 2 determinator, wherein,
Described calibration equipment can obtain the attenuation rate that the brightness on described second Luminance Distribution decays with the distance apart from described light source according to the value of the blood volume in the described reflection blood vessel perienchyma.
4. noinvasive organism assay method comprises:
For containing the step of blood vessel in interior organism illumination;
Take described illumination organism, obtain the step of biometric image;
The step of representing the first Luminance Distribution information of first Luminance Distribution that the blood vessel picture in the cross-section described biometric image distributes according to described biometric image generation;
Generate the step of expression according to being arranged in the blood vessel perienchyma picture of the described biometric image medium vessels of distance along the second Luminance Distribution information of second Luminance Distribution of described biometric image medium vessels picture distribution as the described biometric image of certain distance;
Obtain the step of hemoglobin concentration according to the described first Luminance Distribution information; And
According to the described second Luminance Distribution information described hemoglobin concentration is carried out gauged step.
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| JP2006268930 | 2006-09-29 | ||
| JP2006-268930 | 2006-09-29 | ||
| JP2006268930A JP4963921B2 (en) | 2006-09-29 | 2006-09-29 | Non-invasive living body measurement device |
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| JP2010246578A (en) * | 2009-04-10 | 2010-11-04 | Utsunomiya Univ | Method and apparatus for testing blood cholesterol |
| JP2013031502A (en) * | 2011-08-01 | 2013-02-14 | Sony Corp | Information processing apparatus, information processing method, program, and information processing system |
| CN103126686B (en) * | 2011-11-29 | 2015-02-11 | 原相科技股份有限公司 | Optical distance measuring system and method of operation thereof |
| CN103584870B (en) * | 2013-10-30 | 2016-03-30 | 中南大学湘雅三医院 | Noninvasive hemoglobin tester and detection method thereof |
| JP6442826B2 (en) | 2013-12-27 | 2018-12-26 | セイコーエプソン株式会社 | Blood component analysis method and blood component analyzer |
| CN103767698A (en) * | 2014-01-22 | 2014-05-07 | 中国科学院合肥物质科学研究院 | Vein dynamic characteristic analysis device based on near-infrared spectrum technique and analysis method thereof |
| CN112932416A (en) * | 2015-06-04 | 2021-06-11 | 松下知识产权经营株式会社 | Biological information detection device and biological information detection method |
| CN113109290B (en) * | 2021-04-08 | 2023-03-03 | 晨光生物科技集团股份有限公司 | Method for rapidly predicting attenuation speed of natural pigment |
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| EP1447044A1 (en) * | 2003-02-13 | 2004-08-18 | Sysmex Corporation | Noninvasive living body measuring apparatus |
| CN1620263A (en) * | 2001-01-26 | 2005-05-25 | 三西斯医学股份有限公司 | Noninvasive measurement of glucose through the optical properties of tissue |
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| JP3562847B2 (en) * | 1994-11-15 | 2004-09-08 | 謙 石原 | Hemoglobin concentration measuring device |
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| CN1146354C (en) * | 1995-10-23 | 2004-04-21 | 斯托迈奇克公司 | Apparatus and method for analyzing blood using reflectance spectral imaging |
| US5974338A (en) * | 1997-04-15 | 1999-10-26 | Toa Medical Electronics Co., Ltd. | Non-invasive blood analyzer |
| CN1255077C (en) * | 1998-06-17 | 2006-05-10 | 奥森斯有限公司 | Non-invasive optical measurement of blood constituent |
| CN1620263A (en) * | 2001-01-26 | 2005-05-25 | 三西斯医学股份有限公司 | Noninvasive measurement of glucose through the optical properties of tissue |
| EP1447044A1 (en) * | 2003-02-13 | 2004-08-18 | Sysmex Corporation | Noninvasive living body measuring apparatus |
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