CN101129413A - Polyzyme emulsifying method of traditional Chinese medicine - Google Patents
Polyzyme emulsifying method of traditional Chinese medicine Download PDFInfo
- Publication number
- CN101129413A CN101129413A CNA2007101312250A CN200710131225A CN101129413A CN 101129413 A CN101129413 A CN 101129413A CN A2007101312250 A CNA2007101312250 A CN A2007101312250A CN 200710131225 A CN200710131225 A CN 200710131225A CN 101129413 A CN101129413 A CN 101129413A
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- CN
- China
- Prior art keywords
- chinese medicine
- polyzyme
- minute
- cellulase
- pepsin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 11
- 230000001804 emulsifying effect Effects 0.000 title claims description 7
- 238000004945 emulsification Methods 0.000 claims abstract description 13
- 108010059892 Cellulase Proteins 0.000 claims abstract description 10
- 102000057297 Pepsin A Human genes 0.000 claims abstract description 10
- 108090000284 Pepsin A Proteins 0.000 claims abstract description 10
- 229940106157 cellulase Drugs 0.000 claims abstract description 10
- 229940111202 pepsin Drugs 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 238000002360 preparation method Methods 0.000 claims description 13
- 108010019160 Pancreatin Proteins 0.000 claims description 9
- 229940055695 pancreatin Drugs 0.000 claims description 9
- 235000019834 papain Nutrition 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 8
- 108090000526 Papain Proteins 0.000 claims description 7
- 239000004365 Protease Substances 0.000 claims description 7
- 229940055729 papain Drugs 0.000 claims description 7
- 239000000839 emulsion Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 229940088598 enzyme Drugs 0.000 abstract description 3
- 102000004190 Enzymes Human genes 0.000 abstract description 2
- 108090000790 Enzymes Proteins 0.000 abstract description 2
- 229920001864 tannin Polymers 0.000 abstract description 2
- 235000018553 tannin Nutrition 0.000 abstract description 2
- 239000001648 tannin Substances 0.000 abstract description 2
- 229940088623 biologically active substance Drugs 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 6
- 102000004142 Trypsin Human genes 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 230000028327 secretion Effects 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 208000007117 Oral Ulcer Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a multi-enzyme emulsification process for Chinese medicaments, wherein the constituents include liquid for emulsification 20000-30000 parts, pepsin 3-6 parts, benase 4-8 parts, cellulase 2-4 parts, pancreatic enzymes 4-9 parts. The process can increase the content of biologically active substance in the medicament and lowering the content of tannin.
Description
Technical field
The invention belongs to the Chinese herbal and crude drugs preparations technical field, specifically is a kind of technology that adopts multienzyme ultrasonic emulsification method to prepare Chinese medicine preparation.
Background technology
In the prior art, adopt the preparation method of conventional Chinese patent medicine, different patients, sometimes curative effect differs greatly, except the dialectical factor of the traditional Chinese medical science, stomach, trypsin secretion deficiency, the macromolecular substances in the medicine can not be by fully emulsified, be unfavorable for that body absorbs, and directly affects the curative effect of medicine.Macromolecular substances such as the protein in the medicine can be decomposed into the micromolecule of biologically actives such as many skins, oligopeptide under stomach, trypsin emulsification, absorbed by body.Whole world digestive system disease sickness rate has a strong impact on the secretion of digestive enzyme up to 54.3%.Because side effect such as direct oral stomach, trypsin can cause vomiting, diarrhoea, oral ulcer, and unsatisfactory curative effect.So adopt the polyzyme emulsifying technological process in Chinese medicine preparation, it to be carried out pretreatment, can increase biological activity, improve curative effect, strengthen the Chinese medicine commodity competitiveness on the market at home and abroad.
Summary of the invention
It is a kind of in Chinese medicine preparation technology that purpose of the present invention provides, and is raw material with different enzyme, utilizes ultrasonic emulsification to decompose a kind of Chinese medicine polyzyme emulsifying method of the macromolecular substances raising Chinese medicine preparation curative effect in the Chinese medicine preparation.
The present invention adopts following technical scheme to realize, a kind of Chinese medicine polyzyme emulsifying method is by treating that emulsion 20000-30000 part, pepsin 3-6 part, papain 4-8 part, cellulase 2-4 part pancreatin 4-9 part forms.It is characterized in that Chinese medicine decoction or extractant under normal pressure, temperature 28-36 ℃, PH5.6-6.3 adds pepsin, papain, after cellulase ultrasonic emulsification 30-40 minute, adjust temperature to 90-100 ℃, continue 30 minutes, leave standstill, natural cooling 6 hours is adjusted PH7.1-7.5, temperature 28-36 ℃, added the pancreatin ultrasonic emulsification 30-40 minute under normal pressure, homoiothermic continues 40-50 minute to 90-100 ℃ again, natural cooling then, left standstill 24 hours, and adjusted PH7.1-7.3, relative density 1.10-1.15, siphon goes out medicinal liquid, enters injection again, ball, preparations such as powder.
The present invention in Chinese medicine preparation, increase multienzyme can make contain in the medicament abundant can absorbed bioactive substance.Wherein many skins, polysaccharide etc. improve the micromolecule of immunologic function, improve 27.3% and 18.5% respectively than the conventional formulation flow process, and content of tannin reduces by 31.4, has reduced the pessimal stimulation to digestive system.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1
Get and treat 20000 parts of emulsions, 3 parts of pepsin, 4 parts of papains, 2 parts of cellulase, 4 parts of pancreatin, with Chinese medicine decoction or extractant under normal pressure, temperature 28-36 ℃, PH5.6-6.3, add pepsin, papain, after cellulase ultrasonic emulsification 30-40 minute, adjust temperature to 90-100 ℃, continue 30 minutes, leave standstill, natural cooling 6 hours, adjust PH7.1-7.5, temperature 28-36 ℃, under normal pressure, added the pancreatin ultrasonic emulsification 30-40 minute, homoiothermic is to 90-100 ℃ again, continue 40-50 minute, natural cooling left standstill 24 hours then, adjust PH7.1-7.3, relative density 1.10-1.15, siphon goes out medicinal liquid, enters injection again, ball, preparations such as powder.
Embodiment 2
Get and treat 30000 parts of emulsions, 6 parts of pepsin, 8 parts of papains, 9 parts of 4 parts of pancreatin of cellulase, with Chinese medicine decoction or extractant under normal pressure, temperature 28-36 ℃, PH5.6-6.3, add pepsin, papain, after cellulase ultrasonic emulsification 30-40 minute, adjust temperature to 90-100 ℃, continue 30 minutes, leave standstill, natural cooling 6 hours, adjust PH7.1-7.5, temperature 28-36 ℃, under normal pressure, added the pancreatin ultrasonic emulsification 30-40 minute, homoiothermic is to 90-100 ℃ again, continue 40-50 minute, natural cooling left standstill 24 hours then, adjust PH7.1-7.3, relative density 1.10-1.15, siphon goes out medicinal liquid, enters injection again, ball, preparations such as powder.
Claims (2)
1. Chinese medicine polyzyme emulsifying method is by treating that emulsion, pepsin, papain, cellulase, pancreatin form, and it is characterized in that: the proportioning of each component is:
Treat emulsion 20000-30000 part pepsin 3-6 part
Papain 4-8 part cellulase 2-4 part
Pancreatin 4-9 part is formed.
2. a kind of Chinese medicine polyzyme emulsifying method according to claim 1, it is characterized in that: described preparation method is: with Chinese medicine decoction or extractant under normal pressure, temperature 28-36 ℃, PH5.6-6.3, add pepsin, papain, after cellulase ultrasonic emulsification 30-40 minute, adjust temperature to 90-100 ℃, continue 30 minutes, leave standstill, natural cooling 6 hours, adjust PH7.1-7.5, temperature 28-36 ℃, under normal pressure, added the pancreatin ultrasonic emulsification 30-40 minute, homoiothermic is to 90-100 ℃ again, continue 40-50 minute, natural cooling left standstill 24 hours then, adjust PH7.1-7.3, relative density 1.10-1.15, siphon goes out medicinal liquid, enters injection again, ball, preparations such as powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101312250A CN101129413A (en) | 2007-08-25 | 2007-08-25 | Polyzyme emulsifying method of traditional Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101312250A CN101129413A (en) | 2007-08-25 | 2007-08-25 | Polyzyme emulsifying method of traditional Chinese medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101129413A true CN101129413A (en) | 2008-02-27 |
Family
ID=39126923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101312250A Withdrawn CN101129413A (en) | 2007-08-25 | 2007-08-25 | Polyzyme emulsifying method of traditional Chinese medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101129413A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666762A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of angelica sinensis, paeony and radix rehmanniae composite micro-ecological oral liquid treated by pepsase and trypsin |
| CN104666853A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed lily lung-strengthening micro-ecological oral liquid |
| CN104666854A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed Maiwei rehmannia oral liquid |
| CN104666852A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of maiwei (Chinese character) radix rehmanniae oral liquid treated by pepsase |
| CN104666855A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of lilium compound antiphlogistic oral liquid treated by pepsase |
| CN104666856A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution |
| CN104666733A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed cinnamoni, aconiti preparata and rehmannia oral liquid |
-
2007
- 2007-08-25 CN CNA2007101312250A patent/CN101129413A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666762A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of angelica sinensis, paeony and radix rehmanniae composite micro-ecological oral liquid treated by pepsase and trypsin |
| CN104666853A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed lily lung-strengthening micro-ecological oral liquid |
| CN104666854A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed Maiwei rehmannia oral liquid |
| CN104666852A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of maiwei (Chinese character) radix rehmanniae oral liquid treated by pepsase |
| CN104666855A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of lilium compound antiphlogistic oral liquid treated by pepsase |
| CN104666856A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Method for preparing pepsase and trypsase processed wheat taste rehmannia micro-ecological oral solution |
| CN104666733A (en) * | 2013-11-30 | 2015-06-03 | 白杨 | Preparation method of pepsase and trypsase processed cinnamoni, aconiti preparata and rehmannia oral liquid |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C04 | Withdrawal of patent application after publication (patent law 2001) | ||
| WW01 | Invention patent application withdrawn after publication |