CN101129268A - Fundamental wave harmonic compound imaging method and device - Google Patents
Fundamental wave harmonic compound imaging method and device Download PDFInfo
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- CN101129268A CN101129268A CNA2007101444194A CN200710144419A CN101129268A CN 101129268 A CN101129268 A CN 101129268A CN A2007101444194 A CNA2007101444194 A CN A2007101444194A CN 200710144419 A CN200710144419 A CN 200710144419A CN 101129268 A CN101129268 A CN 101129268A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 40
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- 238000002604 ultrasonography Methods 0.000 claims abstract description 4
- 230000005540 biological transmission Effects 0.000 claims abstract 4
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- 239000002131 composite material Substances 0.000 claims description 7
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Abstract
一种用于基波谐波复合成像方法及装置，属于医学超声成像领域。本发明的原理是：发射器在同一物理位置连续发射两次，第一次发射频率为f0，接收并提取中心频率为2f0的谐波，第二次发射频率为2f0，接收并提取中心频率为2f0的基波，提取基波的边缘信息与谐波的细节信息进行叠加。本发明克服了目前造影谐波成像模式器官边缘模糊的缺点，结果图像组织轮廓清晰、内部细节信息丰富，在医学超声成像系统中有着广泛的应用前景。
The invention discloses a method and device for fundamental wave harmonic compound imaging, belonging to the field of medical ultrasonic imaging. The principle of the present invention is: the transmitter continuously transmits twice at the same physical location, the first transmission frequency is f 0 , receives and extracts the harmonic with a center frequency of 2f 0 , the second transmission frequency is 2f 0 , receives and extracts For the fundamental wave with a center frequency of 2f 0 , the edge information of the fundamental wave is extracted and the detailed information of the harmonic is superimposed. The invention overcomes the defect of fuzzy organ edges in the current contrast harmonic imaging mode. As a result, the tissue outline of the image is clear and the internal detail information is rich, and has wide application prospects in medical ultrasound imaging systems.
Description
Technical field
The present invention relates to the medical ultrasound imaging technology, relate in particular to complex imaging with principal wave harmonic wave method and device.
Background technology
The harmonic imaging technology is nonlinear acoustics fruitful new technique in ultrasonic diagnosis.Traditional ultrasonic image-forming system is the ultrasound wave that transmits and receives same frequency, is called Fundamental Imaging.In fact after echo-signal is subjected to the non-linear modulation of tissue, can produce secondary, the three inferior higher hamonic waves of first-harmonic, wherein secondary harmonic amplitude is the strongest, utilizes the higher hamonic wave imaging method such as secondary of human body echo to be called harmonic imaging.
During Second Harmonic Imaging, instrument, only extracts second harmonic signal and carries out imaging the first-harmonic filtering by bandpass filtering.When contrast-agent-free existed, second harmonic signal came self-organizing, claimed the native tissue harmonic imaging, and when having contrast agent to exist, second harmonic signal claims the radiography harmonic imaging mainly from contrast agent microbubble.Because second harmonic can improve the lateral resolution of image, and enhancing along with harmonic signal, the wavelength of reflective echo reduces, the azimuthal resolution of image improves thereupon, strengthen with harmonic signal simultaneously, the secondary lobe effect weakens, and background clutter also reduces, and horizontal, the vertical and contrast resolution of this sampled images all can have raising by a relatively large margin.Because differing greatly of contrast agent microbubble and surrounding tissue acoustic characteristic, therefore than surrounding tissue particle bigger equivalent scattering area is arranged, add the resonance scattering that microvesicle resonance causes, so stronger from the second harmonic signal of contrast agent microbubble, therefore, the radiography harmonic imaging is used wider clinically.
At present the major defect that exists of radiography harmonic imaging is under radiography harmonic imaging pattern, and the detailed information of organizing that contains a large amount of contrast agent microbubble can clearly be observed, but that the boundary information of organ thickens is unclear.For example when observing human tumor, inject contrast agent after, inside tumor tissue energy clear manifesting, and tumor border does not see Chu, this has influenced the diagnosis of doctor to disease to a great extent.This mainly is because contrast agent microbubble can be penetrated into organization internal, but be difficult to enter organizational boundary, therefore the humorous intensity of wave of organization internal is big, and the humorous intensity of wave on border is little, under the harmonic imaging pattern, the first-harmonic composition is all by filtering, and what highlight is harmonic components, cause organizational boundary's information fuzzy unclear.
Summary of the invention
At the unclear problem of organ boundaries information fuzzy that present radiography harmonic imaging exists, the present invention proposes method and apparatus that Fundamental Imaging and harmonic imaging are combined, makes that the interior details information of organ and boundary information can clearly be observed the while.
Principle of the present invention is: under radiography harmonic imaging pattern, contrast agent microbubble is penetrated into organization internal, make the humorous intensity of wave of organization internal increase, and the humorous intensity of wave on border is little, the harmonic imaging result can obtain the details of organization internal, and makes organization edge fuzzy.Under the Fundamental Imaging pattern, harmonic components is regarded as noise and filters out, fundamental signal intensity dominate, and the border of tissue is very big to the reflex strength of first-harmonic, so sharpness of border.Therefore under the first-harmonic pattern, organizational boundary is clear, and under the harmonic mode, the organization internal detailed information is abundant, simultaneously the signal under two kinds of patterns is compound to together, just can guarantee that two kinds of information are observed simultaneously, thereby overcome the unclear problem of organ boundaries information fuzzy that present radiography harmonic imaging exists.
Concrete signal complex method of the present invention is as follows:
In order not influence the longitudinal resolution of compound back image, fundamental signal and harmonic signal must be in same frequency range.Emitter is in the emission twice continuously of same physical location, and tranmitting frequency is f for the first time
0, receiving and extracting mid frequency is 2f
0Harmonic wave, for the second time tranmitting frequency is 2f
0, receiving and extracting mid frequency is 2f
0First-harmonic, the mid frequency of fundamental signal and harmonic signal all is 2f like this
0In order to reduce operand, the Combined Processing of first-harmonic and harmonic wave is to carry out at the baseband signal after the demodulation, form humorous wave envelope after the harmonic signal demodulation, and it is it is temporary in buffer storage, form the first-harmonic envelope after the fundamental signal demodulation, the first-harmonic envelope can extract the marginal information of first-harmonic envelope through a simple first-order difference computing, and this marginal information is superimposed with the harmonic wave envelope signal that obtains before, can obtain compound echo-signal.
Combined Processing only relates to that signal is temporary, first-order difference and these three kinds of the most basic computings of addition, and logic is simple, is easy to realize that in addition, the signal processing of other parts does not need to do any change.
Description of drawings
Fig. 1 is that first-harmonic and harmonic wave extract sketch map.
Fig. 2 is a digital imaging system imaging system functional block diagram.
Fig. 3 is the demodulator logic block diagram.
Fig. 4 is a principal wave harmonic wave set composite logic diagram.
Among Fig. 2:
100 emitters
200 receptors
300 Beam-formers
400 demodulators
500 principal wave harmonic wave set composites
600 pre-treatments
700 digital scan conversions (DSC)
800 post processings
900 show
Among Fig. 3:
400 demodulators
The logical matched filter of 401 bands
402 remove the absolute value logic circuit
403 low pass filters
404 sampling circuits
Among Fig. 4:
500 principal wave harmonic wave set composites
501 line buffer storage
502 latch
503 subtractors
504 threshold decision logics
The specific embodiment
The present invention is described in further detail below in conjunction with accompanying drawing.
Fig. 1 is that first-harmonic and harmonic wave extract sketch map.Solid line is partly represented the frequency spectrum of received signal among the figure, and dotted portion represents to be with logical matched filter, and chain-dotted line is represented mid frequency.Figure (a) expression tranmitting frequency is f
0The time echo spectrum figure, contain mid frequency in the echo this moment is f
0First-harmonic composition and mid frequency be 2f
0Harmonic components, the employing mid frequency is 2f
0The logical matched filter of band remove first-harmonic and keep harmonic wave.Figure (b) expression tranmitting frequency is 2f
0The time echo spectrum figure, only contain mid frequency in the echo this moment is 2f
0First-harmonic (also should contain mid frequency in theory is 4f
0Harmonic wave, but the probe bandwidth be limited, 4f
0Frequency content generally can't receive), this moment, still to adopt mid frequency be 2f
0The logical matched filter of band to remove out-of-band noise.As seen, for harmonic wave extraction and first-harmonic extraction, it is identical to receive processing, and logical structure and parameter do not need to make any change, just the center-frequency parameters of twice emitting changes just passablely, and the radiating circuit structure does not need to make any change yet.
Fig. 2 is a typical digital imaging system imaging system functional block diagram.Principal wave harmonic wave set composite 500 (abbreviation recombiner) is positioned at after the demodulator 400, before the pre-treatment 600.The groundwork flow process is that emitter 100 produces high-voltage pulse, de-energisation probe array element, the probe echo-signal enters receptor 200 and carries out preposition amplification, variable gain is amplified, signal after the amplification enters Beam-former 300 and carries out the AD sampling, wave beam focuses on, the synthetic wave beam of focusing enters demodulator 400 and carries out detection, data after the detection enter recombiner 500 and carry out the principal wave harmonic wave Combined Processing, data after compound enter pre-processing module 600 and carry out the dynamic range conversion, line correlation, frame is relevant, the edge enhancement process, data after the pre-treatment enter digital scan conversion (DSC-DigitalScan Conversion) module 700 and carry out the conversion of polar coordinate to rectangular coordinate, data behind the DSC enter post-processing module 800 and carry out grey scale transformation, view data after the post processings such as histogram equalization, post processing enters display module 900 and carries out delivering to the display demonstration after video synthesizes.
Fig. 3 is the demodulator logic block diagram.In the logical structure of demodulator 400, rf echo signal at first enters the logical matched filtering module 401 of 32 rank bands, the mid frequency and the bandwidth of the mid frequency of wave filter and bandwidth and echo-signal are complementary, inhibition zone external noise to greatest extent, data after the matched filtering enter the module 402 that takes absolute value, enter low-pass filtering module 403 after taking absolute value, obtain the envelope signal of radiofrequency signal after the low-pass filtering, enter decimation blocks 404 then, sample by super Nyquist sampling thheorem, after the sampling, under the constant situation of the quantity of information of envelope signal, the echo data amount obviously reduces.
Fig. 4 is the logical structure of principal wave harmonic wave set composite (recombiner) 500.Emitter tranmitting frequency for the first time is f
0Pulse the time, K switch 1 is connected, K2 disconnects, mid frequency is 2f
0Harmonic signal through matched filtering, separate and be stored in the line buffer storage 501 after be in harmonious proportion extracting.Emitter tranmitting frequency for the second time is 2f
0Pulse the time, K switch 1 disconnects, K2 connects, mid frequency is 2f
0Fundamental signal through matched filtering, separate and enter one by the 502 and 503 first-order difference devices of forming after be in harmonious proportion extracting, wherein 502 is latch, data are done the delay of a clock cycle, 503 is subtractors, difference obtains the edge confidence of fundamental signal envelope later, the harmonic signal of itself and line buffer 501 correspondence positions is superimposed, and the value of superposed signal is passed through threshold decision logic 504 carry out threshold decision, greater than 255 be taken as 255, less than 0 be taken as 0, the gray value of superposed signal is controlled between 0～255.Data after the Combined Processing are sent to the pre-treatment link, and follow-up signal processing mode and traditional digital imaging system imaging system are identical.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102551808A (en) * | 2012-02-29 | 2012-07-11 | 飞依诺科技(苏州)有限公司 | Imaging method for graph expansion in ultrasonic diagnosis |
| CN103202713A (en) * | 2013-01-31 | 2013-07-17 | 声泰特（成都）科技有限公司 | Image optimization method by blending of ultrasound fundamental wave and harmonic wave |
| CN106175823A (en) * | 2014-08-20 | 2016-12-07 | 三星电子株式会社 | The supersonic diagnostic appts producing harmonic image and the method producing ultrasonoscopy |
| CN108474844A (en) * | 2015-12-30 | 2018-08-31 | 皇家飞利浦有限公司 | System and method for dynamic filter |
| CN109799284A (en) * | 2019-01-29 | 2019-05-24 | 云南大学 | A kind of multiple harmonic auto-adaptive separating method of ultrasound echo signal |
| CN111050655A (en) * | 2017-05-28 | 2020-04-21 | 利兰斯坦福初级大学董事会 | Ultrasound imaging with nonlinear positioning |
-
2007
- 2007-10-09 CN CNA2007101444194A patent/CN101129268A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102551808A (en) * | 2012-02-29 | 2012-07-11 | 飞依诺科技(苏州)有限公司 | Imaging method for graph expansion in ultrasonic diagnosis |
| CN103202713A (en) * | 2013-01-31 | 2013-07-17 | 声泰特（成都）科技有限公司 | Image optimization method by blending of ultrasound fundamental wave and harmonic wave |
| CN106175823A (en) * | 2014-08-20 | 2016-12-07 | 三星电子株式会社 | The supersonic diagnostic appts producing harmonic image and the method producing ultrasonoscopy |
| CN106175823B (en) * | 2014-08-20 | 2019-12-13 | 三星电子株式会社 | Ultrasound diagnostic apparatus for generating harmonic images and method for generating ultrasound images |
| CN108474844A (en) * | 2015-12-30 | 2018-08-31 | 皇家飞利浦有限公司 | System and method for dynamic filter |
| CN108474844B (en) * | 2015-12-30 | 2023-07-14 | 皇家飞利浦有限公司 | Systems and methods for dynamic filtering |
| CN111050655A (en) * | 2017-05-28 | 2020-04-21 | 利兰斯坦福初级大学董事会 | Ultrasound imaging with nonlinear positioning |
| US11369343B2 (en) | 2017-05-28 | 2022-06-28 | The Board Of Trustees Of The Leland Stanford Junior University | Ultrasound imaging by nonlinear localization |
| CN109799284A (en) * | 2019-01-29 | 2019-05-24 | 云南大学 | A kind of multiple harmonic auto-adaptive separating method of ultrasound echo signal |
| CN109799284B (en) * | 2019-01-29 | 2021-07-02 | 云南大学 | Multi-harmonic self-adaptive separation method for ultrasonic echo signals |
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