CN101112613B - Medicine for treating cholecystitis, gastritis and hepatitis and method for preparing the same - Google Patents

Abstract

The present invention discloses a syrup of benefiting gall bladder and stomach for the treatment of cholecystitis, gastritis and hepatitis, which is prepared by Chinese thorowax root, pinellia tuber, bitter orange, Indian buead, villous amomum fruit, turmeric root-tuber, hawthorn fruit, baical skullcap root and malt according to certain mixing ratio by weight; the drug of the present invention has the functions of clearing heat and fire, antibacterial, anti-inflammatory, benefiting gall bladder and stomach, soothing liver, anti-depression, relaxing chest and regulating qi and has the fast efficacy and high cure rate for the treatment of cholecystitis, gastritis and hepatitis.

Description

A kind of medicine for the treatment of cholecystitis, gastritis, hepatitis and preparation method thereof

Technical field:

The present invention relates to a kind of medicine for the treatment of cholecystitis, gastritis, hepatitis and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Cholecystitis, gastritis, hepatitis are common disease, clinical respectively with nausea and vomiting, stomachache, costa sternales pain, headache, heart beating are feature, western medical treatment is with local application, anti-inflammation or add the calmness class medicine symptomatic treatment that relieves the pain, these medicines can only be alleviated or treat focus, can't thoroughly cure or eradicate.

Summary of the invention:

So there is great demand in the Chinese medicine preparation that people treat cholecystitis, gastritis, hepatitis preferably to curative effect, up to now, also do not find the report of relevant pharmaceutical composition of the present invention, the inventor is through research repeatedly, and the checking repeatedly by animal and clinical trial, finally find the oral medicinal herb medicine of better curative effect, thereby finished the present invention.

Purpose of the present invention just provides a kind of Chinese medicine function of gallbladder promoting stomach function regulating syrup of more effectively treating cholecystitis, gastritis, hepatitis.

Another object of the present invention has just provided this preparation method of Chinese medicine.

Medicament selection Radix Bupleuri of the present invention, the Rhizoma Pinelliae, Fructus Aurantii, Pericarpium Citri tangerinae, Poria, Fructus Amomi, Radix Curcumae, Radix Scutellariae, Fructus Crataegi, Fructus Hordei Germinatus, Semen Ziziphi Spinosae, Semen Raphani, Caulis Bambusae In Taenia, the Radix Paeoniae Alba, Radix Glycyrrhizae and Rhizoma Zingiberis Recens make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of cholecystitis, gastritis, hepatitis.Wherein selecting Radix Bupleuri for use is because of its nature and flavor hardship, cold, goes into liver, gallbladder meridian.Reconciling superficies and interior is arranged, soothing the liver, the yang invigorating function.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste ear

Deaf, malaria, diarrhea proctoptosis, menoxenia, uterine prolapse.Selecting the Rhizoma Pinelliae for use is because of its nature and flavor suffering, temperature, goes into spleen, stomach warp.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control the damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, septum pectorale distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.Selecting Fructus Aurantii for use is because of its nature and flavor hardship, suffering, cold, goes into lung, spleen, large intestine channel.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant and stagnate, the feeling of stuffiness in chest, the side of body expands, food stagnation, eructation, vomiting, heavy behind the dysentery, proctoptosis, uterine prolapse.Selecting Pericarpium Citri tangerinae for use is because of Pericarpium Citri tangerinae nature and flavor suffering, hardship, temperature, goes into the spleen lung meridian, in the reasonable controlled atmosphere, and the function of drying dampness to eliminate phlegm.Control distension and fullness of the chest and abdomen, anorexia, vomiting hiccup, cough with copious phlegm.Also separate fish, Eriocheir sinensis poison.Select for use Poria to be because its nature and flavor are sweet, light, flat, go into the heart, spleen, lung meridian.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Selecting Fructus Amomi for use is because of its nature and flavor suffering, temperature, goes into spleen, stomach warp.During circulation of qi promoting was transferred, stomach function regulating was amusing.Control the stomachache painful abdominal mass and expand anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Select for use Radix Curcumae to be because its nature and flavor are arduous, cool, go into the heart, lung, Liver Channel.Promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, it is demented to lose the heart, and the calentura coma is spitted blood epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select for use Radix Scutellariae to be because its nature and flavor hardship, cold is gone into the heart, lung, gallbladder, large intestine channel.The removing the relative excess fire, except that damp and hot, hemostasis, antiabortive.Control the high fever excessive thirst, the cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria is told, is defeated in battle, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle is treated skin ulcer.Select for use Fructus Crataegi to be because sweet, the tepor of its nature and flavor acid is gone into spleen, stomach, Liver Channel.It is long-pending to help digestion, dissipating blood stasis blood, expelling tenia.Control meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's's breast food is stagnated.Select for use Fructus Hordei Germinatus to be because sweet, the tepor of its nature and flavor is gone into spleen, stomach warp.Help digestion and in, the therapeutic method to keep the adverse QI flowing downwards.Control food stagnation and do not disappear, distension and fullness in the abdomen, inappetence, vomiting is had loose bowels, and mammary swelling does not disappear.Select for use Semen Ziziphi Spinosae to be because the Semen Ziziphi Spinosae nature and flavor are sweet, put down GUIXIN, lung, liver, gallbladder meridian.Nourishing the liver, mind calming, calm the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Select for use Semen Raphani to be because its nature and flavor suffering, sweet, flat.The function that has therapeutic method to keep the adverse QI flowing downwards Dingchuan to eliminate indigestion and phlegm.Control the cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, heavy behind the dysentery.Select for use Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, go into stomach, gallbladder meridian.Heat clearing away, removing heat from blood reduces phlegm, emesis.Control dysphoria with smothery sensation vomiting, singultus, the expectorant heat syndrome cough is breathed heavily, and spits blood epistaxis, metrorrhagia, malignant histocytosis, fetal movement, infantile convulsion.Selecting Radix Paeoniae Alba for use is because of its nature and flavor hardship, acid, cold, goes into liver, spleen channel.Nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.It is sweet because of its nature and flavor, flat selecting Radix Glycyrrhizae for use, goes into spleen, stomach, lung meridian.With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Process usefulness, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus, infantile convulsion; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated attainment in poison of drug and the food.Adopting Rhizoma Zingiberis Recens is because of its nature and flavor suffering, temperature, goes into lung, stomach, spleen channel.Deliver, cold expelling, preventing or arresting vomiting is opened expectorant.The wind and cold that cures cold, vomiting, phlegm retention is breathed with cough, and distension is had loose bowels; Separate the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poison.

Amount of drug of the present invention also is to sum up through a large amount of the groping of inventor to draw, and each amount of drug all has better curative effect in following weight range:

Radix Bupleuri 10-15 gram Rhizoma Pinelliae 3-7 gram

Fructus Aurantii 5-10 gram Pericarpium Citri tangerinae 2-8 gram

Poria 15-25 gram Fructus Amomi 5-10 gram

Radix Curcumae 5-10 gram Radix Scutellariae 5-10 gram

Fructus Crataegi 20-25 gram Fructus Hordei Germinatus 15-20 gram

Semen Ziziphi Spinosae 15-25 gram Semen Raphani 5-15 gram

Caulis Bambusae In Taenia 4-8 gram Radix Paeoniae Alba 15-20 gram

Radix Glycyrrhizae 5-10 gram Rhizoma Zingiberis Recens 5-10 gram

The preparation method of medicine of the present invention is as follows:

One, the process of preparing Chinese medicine of crude drug

(1) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through back section in time, dry immediately.

(2) Rhizoma Pinelliae: choose clean impurity, sieve dedust bits.

(3) Fructus Aurantii (parched): get wheat bran and be spread in the heat pot, when the yellow skin of waiting is smoldered, add the Fructus Aurantii sheet, fry to faint yellow, take out, sieve removes wheat bran, cools.100 jin of every Fructus Aurantii sheets are with 10 jin in wheat bran.

(4) Pericarpium Citri tangerinae: brush away earth, choose clean impurity, the spray clear water, stewing profit back shredding or section are dried.

(5) Poria: be soaked in water, clean, pull out, stewing saturating after, section is dried.

(6) Fructus Amomi: remove impurity and shell, smash to pieces.

(7) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section is dried.

(8) Radix Scutellariae (parched): get scutellaria tablet spray yellow wine, mix thoroughly, with the little stir-fry of slow fire, taking-up is dried.100 jin of every Radix Scutellariaes are with yellow wine 10-15 jin.

(9) Fructus Crataegi: choose clean impurity, the sieve enucleation.

(10) Fructus Hordei Germinatus: choose clean impurity, the big yellow skin of choosing grain, plump seed.

(11) Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in the pot to fry to crust with slow fire and heave, and be little yellow, taking-up cools.

(12) Semen Raphani (parched): get clean Semen Raphani, put in the pot and fry to little heaving with slow fire, and fragrance degree of being is arranged, taking-up cools.

(13) Caulis Bambusae In Taenia: select yellow green for use, the Caulis Bambusae In Taenia that silk is evenly soft.

(14) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying.

(15) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through section, dry.

(16) Rhizoma Zingiberis Recens: choose decontamination, clean earth, the time spent section.

Two, preparation

(1) adds water 2000 grams by measuring sufficient said medicine, decocted 90 minutes, leach medicinal liquid 1000 grams;

(2) medicinal residues are added water 1000 grams again, decocted 60 minutes, leach medicinal liquid 800 grams;

(3) twice medicinal liquid merged, left standstill 6-10 hour, disgorging, reconcentration to 260 gram adds brown sugar 120 grams, boils 30 minutes again, cools bottling.

Medicine of the present invention has functions such as clearing away heat-fire, anti-inflammation, function of gallbladder promoting stomach function regulating, the chest stuffiness relieving are regulated the flow of vital energy, dispersing the stagnated live-QI to relieve the stagnation of QI, is used for the treatment of cholecystitis, gastritis, hepatitis good effect, the cure rate height.

The specific embodiment:

Below further sets forth the beneficial effect of medicine of the present invention by testing example, test the routine toxicity test of medicine of the present invention and the clinical observation on the therapeutic effect of comprising and test.

[test example 1] medicine of the present invention is to the toxicity test of rabbit

Get 20 of new zealand rabbits, male and female and usefulness, body weight 2.0-2.5kg is divided into 2 groups, and 10 every group, wherein 1 group is the normal amount test, and 1 group is the super quantity test in addition.

Function of gallbladder promoting stomach function regulating syrup is taken for the normal amount group by every each 1.25 grams of rabbit; Every each 3.75 grams of rabbit are taken to the super quantity group, and the super quantity dosage is 3 times of normal amount; By above-mentioned dosage the administration by gavage administration is adopted in the dilution of function of gallbladder promoting stomach function regulating syrup, administering mode is secondary every day, serve on 7 days.Observe medication reaction every day, the result shows that two groups of rabbit are taken medicine, and all are movable normal in the back, all have no adverse reaction, and medicine of the present invention has no side effect.

[test example 2] medicine of the present invention is to the clinical observation material of treatment cholecystitis, gastritis, hepatitis

1, physical data

Accept out-patient's totally 98 examples for medical treatment, 16-30 year 28 examples wherein, 31-40 year 20 examples, 41-50 year 29 examples, 21 examples more than 50 years old.

2, diagnostic criteria

1. cholecystitis: nausea and vomiting, poor appetite, the lighter is uncomfortable in chest, severe patient breast muscle pain, mouth is told yellow liquid, obstinate.

2. gastritis: gastric area pain, abdominal part distension, inappetence, flatulence, vomiting, belch.

3. hepatitis: dizzy headache, nervous heart beating, severe patient costa sternales distension, limbs are become thin, myasthenia of limbs, skin is dark yellow.

3, Therapeutic Method

Every day three times, each 30-40 gram, 10 is a course of treatment, serve on 2-3 the course of treatment.

4, efficacy evaluation

Produce effects: behind drug treatment, various transference cures, physical recovery is normal, observes 3 months no recidivists:

Take a turn for the better: various sxs, pain disappears, and appetite is recovered, and body constitution progressively takes a turn for the better.

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In the treatment of above 3 courses of treatment, with function of gallbladder promoting stomach function regulating syrup treatment cholecystitis 27 examples, produce effects 22 is fallen as a result, 3 examples that take a turn for the better, and invalid 2 examples, obvious effective rate is 81.48%, and improvement rate is 11.11%, and total effective rate is 92.60%.

In the treatment of above 3 courses of treatment, with function of gallbladder promoting stomach function regulating syrup treatment gastritis 50 examples, produce effects 43 examples as a result, 6 examples that take a turn for the better, invalid 1 example, obvious effective rate is 86%, and improvement rate is 12%, and total effective rate is 98%.

In the treatment of 3 courses of treatment, with function of gallbladder promoting stomach function regulating syrup treatment hepatitis 21 examples, produce effects 16 examples as a result, 2 examples that take a turn for the better, invalid 3 examples, obvious effective rate is 76.19%, and improvement rate is 9.52%, and total effective rate is 85.71%.

Claims (2)

1. medicine for the treatment of cholecystitis, gastritis, hepatitis, it is characterized in that: it is to be made by the crude drug of following weight range:

Radix Bupleuri 10-15 gram Rhizoma Pinelliae 3-7 gram

Fructus Aurantii 5-10 gram Pericarpium Citri tangerinae 2-8 gram

Poria 15-25 gram Fructus Amomi 5-10 gram

Radix Curcumae 5-10 gram Radix Scutellariae 5-10 gram

Fructus Crataegi 20-25 gram Fructus Hordei Germinatus 15-20 gram

Semen Ziziphi Spinosae 15-25 gram Semen Raphani 5-15 gram

Caulis Bambusae In Taenia 4-8 gram Radix Paeoniae Alba 15-20 gram

Radix Glycyrrhizae 5-10 gram Rhizoma Zingiberis Recens 5-10 gram.

2. according to the preparation method of the described medicine of claim 1, it is characterized in that: it comprises the following steps:

(1) process of preparing Chinese medicine of crude drug

(1) Radix Bupleuri: choose decontamination, remove residual stem, clean silt, pull out, run through back section in time, dry immediately;

(2) Rhizoma Pinelliae: choose clean impurity, sieve dedust bits;

(3) Fructus Aurantii (parched): get wheat bran and be spread in the heat pot, when the yellow skin of waiting is smoldered, add the Fructus Aurantii sheet, fry to faint yellow, take out, sift out wheat bran, cool, 100 jin of every Fructus Aurantii sheets are with 10 jin in wheat bran;

(4) Pericarpium Citri tangerinae: brush away earth, choose clean impurity, the spray clear water, stewing profit back shredding or section are dried;

(5) Poria: be soaked in water, clean, pull out, stewing saturating after, section is dried;

(6) Fructus Amomi: remove impurity and shell, smash to pieces;

(7) Radix Curcumae: be soaked in water, clean, pull out to shine and dry in the air, run through, section is dried;

(8) Radix Scutellariae (parched): get scutellaria tablet spray yellow wine, mix thoroughly, with the little stir-fry of slow fire, taking-up is dried, and 100 jin of every Radix Scutellariaes are with yellow wine 10-15 jin;

(9) Fructus Crataegi: choose clean impurity, the sieve enucleation;

(10) Fructus Hordei Germinatus: choose clean impurity, the big yellow skin of choosing grain, plump seed;

(11) Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in the pot to fry to crust with slow fire and heave, and be little yellow, taking-up cools;

(12) Semen Raphani (parched): get clean Semen Raphani, put in the pot and fry to little heaving with slow fire, and fragrance degree of being is arranged, taking-up cools;

(13) Caulis Bambusae In Taenia: select yellow green for use, the Caulis Bambusae In Taenia that silk is evenly soft;

(14) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(15) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant when saturating, pull out, run through section, dry;

(16) Rhizoma Zingiberis Recens: choose decontamination, clean earth, the time spent section;

(2) preparation

(1) adds water 2000 grams by measuring sufficient said medicine, decocted 90 minutes, leach medicinal liquid 1000 grams;

(2) medicinal residues are added water 1000 grams again, decocted 60 minutes, leach medicinal liquid 800 grams;

(3) twice medicinal liquid merged, left standstill 6-10 hour, disgorging, reconcentration to 260 gram adds brown sugar 120 grams, boils 30 minutes again, cools bottling.