CN101095769B - Health-care food for reducing blood lipid and method for preparing the same - Google Patents
Health-care food for reducing blood lipid and method for preparing the same Download PDFInfo
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Abstract
The invention relates to a health food for lowering blood fat and process for preparation, wherein the food is prepared from the following raw materials (by weight portion): haw 5-20, dried lemon 5-20, Pu'er tea 3-12, prepared fleece-flower root 3-12, safflower 2-6 and alisol 2-6.
Description
Technical field
The present invention relates to the health food technology field, health food of a kind of blood fat reducing specifically and preparation method thereof.Therapeutical effect is arranged again.
Background technology
The hyperlipidemia card belongs to commonly encountered diseases in clinical, its sickness rate also obviously increases with advancing age.In the U.S., surpass 100,000 people every year and die from coronary heart disease, wherein 1/3rd people is discontented 55 years old, and the direct and letter that causes thus connects economic loss more than 100,000,000,000 dollars.Argentina shows four the city crowds' more than 20 years old in middle part Epidemiological study at 1995-1998, and hypertension that is closely related with coronary heart disease and hyperlipidemia endanger in the crowd and reach more than 30%.Hyperlipidemia also is to cause the main risk factor of Japanese cardiovascular disease, particularly coronary heart disease.
In recent years, developing country is (saturated fat and intake increase and under complex carbohydrate and the coarse-fibred pinch amount of getting degradation), blue-collar decline factors such as (activity minimizings) because the change of growth in the living standard, diet structure, causes the sickness rate of hyperlipidemia to increase year by year.China's healthy population blood lipid level investigation is found that men and women crowd's blood T-CHOL and LDL level all rise than before, cause dangerous remarkable the increasing of coronary heart disease.
Doctor trained in Western medicine is all obtaining very big progress to hyperlipemia aspect theory research, the experimentation at present, the mechanism of metabolism disorder of blood lipid and the relation between blood fat and the cardiovascular and cerebrovascular disease have been done deep research, but clinical effectiveness is undesirable.The particularly long expiration side effect of taking medicine is still a great problem of treatment hyperlipemia.And expensive blood fat reducing Western medicine also is to be difficult to bear for most of Chinese average families.
Recent two decades comes, and Chinese medicine has been obtained gratifying progress aspect the hyperlipemia preventing and treating.According to theory of Chinese medical science, hyperlipemia is the disease of deficiency in origin and excess in superficiality.Chinese medicine transfers the fat effect mainly to realize by four aspects: 1, suppress intestinal absorption; 2, suppressing endogenous TC, TG synthesizes; 3, regulate intravital lipid metabolism; 4, promote the body inner cholesterol to drain.Use the report of Chinese medicine prevention hyperlipemia at present, covered many-sides such as single medicinal material, compound recipe, acupuncture, find that existing more than 60 kind of Chinese herbal medicine and food have treatment and preventive effect to hyperlipemia.
At present, the Chinese medicine compound of treatment hyperlipemia is more, mainly contains:
1. the Yunnan pollen tianqi oral liquid is made up of pollen of Semen Fagopyri Esculenti/Typhonium flagelliforme (Lodd.) Blume/Mel, is applicable to the syndrome of static blood blocking collaterals of hyperlipemia;
2. JIANGZHILINGPIAN is made up of Radix Polygoni Multiflori Preparata/Semen Cassiae/Rhizoma Polygonati/Radix Aucklandiae/Fructus Crataegi/Fructus Rosae Laevigatae etc., is applicable to the syndrome of yin deficiency of liver and kidney of hyperlipemia;
3. xinqingning tablet is made up of Radix Et Rhizoma Rhei, is applicable to the pyretic toxicity inner product card of hyperlipemia;
4. fat can be made up of Semen Lepidii/Radix Scutellariae/Fructus Crataegi/Rhizoma Alismatis/Radix Et Rhizoma Rhei/Radix Aucklandiae clearly, is applicable in the phlegm-damp of hyperlipemia to accumulate card;
5. Radix Polygoni Multiflori tablet is made up of the Radix Polygoni Multiflori, is used for the syndrome of yin deficiency of liver and kidney of hyperlipemia;
6. SHANZHAJING JIANGZHI PIAN is made up of Fructus Crataegi, is applicable to the interior card that stagnates of the food stasis of blood of hyperlipemia.
Above medicine belongs to a bit cures the symptoms, not the disease, and some uses expensive composition, and some does not interrupt using owing to auxiliary treatment is good in application process.
Summary of the invention
It is little, cheap to the purpose of this invention is to provide a kind of determined curative effect, safe ready, side effect, and hyperlipidemia and atherosclerosis are had the health food of health care preventive effect and its preparation method.
Health food of the present invention is to be formed by following weight portion preparation of raw material: Fructus Crataegi 5-20, Fructus Citri Limoniae does 5-20, Folium camelliae assamicae 3-12, Radix Polygoni Multiflori Preparata 3-12, Flos Carthami 2-6, Rhizoma Alismatis 2-6.
Optimum weight part proportioning of above-described health food is: Fructus Crataegi 10, Fructus Citri Limoniae does 10, Folium camelliae assamicae 6, Radix Polygoni Multiflori Preparata 6, Flos Carthami 3, Rhizoma Alismatis 3.
Use above-mentioned raw materials, be equipped with suitable adjuvant and can be made into capsule, soft capsule, tablet or other oral formulations.
The preparation method of health food of the present invention may further comprise the steps:
1) dried, the Folium camelliae assamicae and Flos Carthami of Fructus Citri Limoniae was soaked 1-3 hour, reflux 2-4 time, and each 1-4 hour, collection volatile oil, the medicinal liquid filtered while hot, filtrate merges, and concentrates, and drying under reduced pressure is extremely done, and pulverizes the 80-200 order, gets dry extract 1;
2) Fructus Crataegi, Radix Polygoni Multiflori Preparata and Rhizoma Alismatis are used 70-80% ethanol extraction 2-4 time, and each 1-4 hour, medical filtration, filtrate recycling ethanol concentrates, and drying under reduced pressure was pulverized the 80-200 order to doing, and got dry extract 2;
3) dry extract 1 and dry extract 2 are mixed, get total extractum;
Perhaps:
Fructus Crataegi, Fructus Citri Limoniae do, Folium camelliae assamicae, Radix Polygoni Multiflori Preparata, Flos Carthami and Rhizoma Alismatis, soaked 1-3 hour, and reflux 2-4 time, each 1-4 hour, collect volatile oil, the medicinal liquid filtered while hot, the filtrate merging, concentrating under reduced pressure, spray drying gets extractum, and is standby;
4) with the total extractum of above gained, add the microcrystalline Cellulose adjuvant, mixing, 70-90% ethanol system granule, drying, granulate add volatile oil, lubricant, mix homogeneously, compacting is in blocks according to a conventional method, and the bag film-coat gets Film coated tablets;
Perhaps:
Volatile oil adds the microcrystalline Cellulose mix homogeneously, adds total extractum of above gained, and mix homogeneously adds the lubricant mixing, and the dress hard capsule is made hard capsule.
Perhaps:
With the total extractum of above gained, 80 ℃ of drying under reduced pressure to water content less than 3%, add in the soybean oil-beeswax mixture of 40-60 ℃ of insulation with volatile oil, soybean oil, mellisic weight ratio are 22: 1, stir, ground 10-30 minute, and crossed 100～200 mesh sieves, 30-60 ℃ is pressed into soft capsule.
The present invention has the health care of blood fat reducing, and hyperlipemia and coronary heart disease are had prevention and auxiliary treatment effect.The present invention is Chinese medicine preparation (being the integration of edible and medicinal herbs medicine), action temperature and, side effect is little, can take for a long time, truly has the effect of blood fat reducing through clinical confirmation for many years.The inventor has also carried out toxicology test, function assessment test to capsule, and its result confirms that also it has the effect of blood fat reducing, and safe toxicological test confirmation this product is taken safety for a long time.
Below be the experimental data of function and effect:
One. capsule function assessment animal test results of the present invention
1. dosage
Everyone (by the 60kg weighing machine) recommended intake every day is capsule 's content 4.5g (is equivalent to Fructus Crataegi 10g Fructus Citri Limoniae and does 10g Folium camelliae assamicae 6g Radix Polygoni Multiflori Preparata 6g Flos Carthami 3g Rhizoma Alismatis 3g).Being converted into every day kg body weight dosage is 0.075g/kg.bw, presses 5 times of human body recommended intakes, 10 times, 25 times basic, normal, high 3 the dosage groups of design respectively, promptly 0.375,0.750,1.875g/kg.bw.
2. test method: carry out according to " health food check and assessment technique standard " (version in 2003).Experiment is with cleaning level Wistar rat.Getting body weight is the healthy adult male rat of 200 ± 20g, random packet, and 10 every group experimentize.
High lipid food: 78.8% normal feedstuff, 1% cholesterol, 10% yolk powder and 10% Adeps Sus domestica, 0.2% cholate.
2.1 capsule is to the preventive effect of normal serum lipids in rats
Under experimental situation, the rat feeding normal feedstuff is observed 10d, and the tail vein is got blood, measures serum total cholesterol (TC), triglyceride (TG), and HDL-C (HDL-C) level is carried out random packet according to the TC level.Since the 11st day, matched group gave normal feedstuff, and model group gives high lipid food, and experimental group gives the given the test agent 45d of high, medium and low dosage when giving high lipid food.The routine weighing body weight finishes fasting 16 hours in experiment, surveys serum TC, TG, HDL-C level.Experimental result sees Table 1.
Table 1 capsule to the influence of normal rat body weight and blood fat (x ± SD, n=10)
Compare with model group,
*P＜0.05,
*P＜0.01 (as follows)
The result shows, compares with model group, and TC, the TG of high agent group rat and HDL-C all have significantly descend (P＜0.01) in the capsule.Low dose group TC and TG all have decline (P＜0.05)
2.2 capsule is to the influence of hyperlipidemia rats blood fat
Under experimental situation, the rat feeding normal feedstuff is observed 10d, and the tail vein is got blood, measures horizontal branch.Carry out random packet according to the TC level.Since the 11st day, remove 10-12 and only continue to give normal feedstuff, its rat is then used high lipid food instead, continues to feed 10d.The tail vein is got blood then, measures TC, and TG and HDL-C carry out random packet according to the TC level.The given the test agent per os is irritated stomach, and model group is then given the solvent with volume, continues to give high lipid food 45d.The routine weighing body weight finishes back fasting 16 hours in experiment, surveys serum TC, TG, HDL-C level.Experimental result sees Table 2.
Table 2 capsule to the influence of hyperlipidemia rats body weight and blood fat (x ± SD, n=10)
The result shows, with model group relatively, TC, the TG of the high agent group of capsule rat all has remarkable decline (P＜0.01), HDL-C significantly descend (P＜0.05).Middle dosage group TC, TG and HDL-C all have decline (P＜0.05).
To sum up, capsule of the present invention has good preventing and therapeutical effect to hyperlipemia.
Two, health food safety toxicological test of the present invention
Test basis: carry out according to " health food check and assessment technique standard " (version in 2003).Experiment is with cleaning level Kunming mouse and cleaning level Wistar rat.
1) 30 days feeding trials of rat
Assay and evaluation: the Wistar healthy rat is contained 0.50%, 1.00%, 2.00% capsular pellet every day, dosage is 1.875,3.750,7.500g/kg.bw, be equivalent to 25,50,100 times of human body recommended amounts, test period totally 30 days, result of the test is:
1) the general physiology sign of rat, behavior, defecation, fur etc. are all no abnormal.
2) body weight and food utilization index are normal
3) the blood routine index is normal
4) biochemical indicator is no abnormal
5) each organ coefficient index is normal
6) inspection substantially of organs such as each rat heart, liver,spleen,kidney, small intestinal, testis is no abnormal; The liver of matched group and high dose group rat, kidney and the pathological observation result of small intestine are basic identical, do not see special pathological change.
2. its mouse oral acute toxicity test (LD
50)
Male, female mice per os LD50＞30g/kg.b.w are tried thing capsule of the present invention and are belonged to nontoxic level material.
3. mouse bone marrow cells micronucleus test
The micronucleus result of 50～10.0g/kg.b.w dosage is negative, is tried thing capsule of the present invention somatic cell is not had mutagenesis.
4. mouse sperm deformity test
The spermatic aberration test result of 50～10.0g/kg.b.w dosage is negative, is tried thing capsule of the present invention sexual cell is not had mutagenesis.
5.Ames test
8-5000 μ g/ ware is tried thing Salmonella typhimurium strain TA97, TA98, TA1000, TA102 is carried out the plate infiltration test, no matter when adding and do not add the S9 mixed liquor, each dosage group does not cause that all the back mutation bacterium colony of test strain significantly increases, the Salmonella reversion test result is negative, is tried thing capsule of the present invention and does not have direct or indirect mutagenic action.
Above presentation of results, capsule of the present invention does not have obvious toxic and side effects.
Three, capsule is to strengthening body immunity and improving the function of remembering
1. object of study
The adult who (contains 65 years old) below 65 years old more than 18 years old, simple dyslipidemia, blood sampling is 2 times in half a year, twice serum TC all 〉=5.20mmol/L, or TG 〉=1.65mmol/L.
The exclusion standard age is this person more than 5 years old perhaps below year; Gestation and women breast-feeding their children are to the health food allergy sufferers; Merge to have the inclination, serious diseases such as liver/kidney and hemopoietic system; The psychotic; Take the article relevant in a short time with being tried function.
2. method of administration
The adult, each 5, every day 3 times.
Above object of study was a course of treatment with one month all, treated 3 courses of treatment.
3, observational technique:
By patient's readme spirit, sleep, diet, defecation and blood pressure; Carry out blood, urine, just routine test regulating liver-QI, kidney function test; And carry out Chest X-rays, electrocardiogram and Abdominal B type ultrasonography inspection, carry out safety evaluatio.
4, effect evaluation
4.1 criterion produce effects: TC descends 〉=20%, TG descends 〉=40%, DL-C) rising 〉=0.26mmol/L; Effectively: TC descends 〉=10～20%, and TG descends 0～40%, the HDL-C 0.10～0.26mmol/L that rises; Invalid: as not reach above-mentioned standard.
4.2 the result carries out the human feeding trial in 6 weeks by a definite date to 159 routine patients, its effect sees Table 3:
The human feeding trial result (n=159) in table 36 week
Side effect of the present invention: period in a medicine does not have any untoward reaction.
Clinical research shows that capsule of the present invention has tangible assosting effect to hyperlipemia, and non-evident effect.
The specific embodiment
Embodiment 1
Get parts by weight of raw materials (kilogram): Fructus Crataegi 10, Fructus Citri Limoniae does 10, Folium camelliae assamicae 6, Radix Polygoni Multiflori Preparata 6, Flos Carthami 3, Rhizoma Alismatis 3
Get parts by weight of raw materials (kilogram): Fructus Crataegi 10, Fructus Citri Limoniae does 10, Folium camelliae assamicae 6, Radix Polygoni Multiflori Preparata 6, Flos Carthami 3, Rhizoma Alismatis 3 microcrystalline Cellulose 0.06, Pulvis Talci 0.04.
Take by weighing above-mentioned weight medical material, be soaked in water 1 hour, reflux 1.5 hours (collecting volatile oil simultaneously), filtered while hot, residue adds 6 times of water gagings and refluxed 1 hour, filtered while hot, filtrate merges, and gets extract powder after the spray drying, and is standby; Get microcrystalline Cellulose and volatile oil mix homogeneously, add in the above-mentioned extract powder, mix homogeneously adds the Pulvis Talci mixing again, the dress hard capsule.
Embodiment 2
Get parts by weight of raw materials (kilogram): Fructus Crataegi 8, Fructus Citri Limoniae does 8, Folium camelliae assamicae 16, Radix Polygoni Multiflori Preparata 3, Flos Carthami 6, Rhizoma Alismatis 3, starch 0.06, Pulvis Talci 0.04.
Preparation by the following method:
Get that Fructus Citri Limoniae does, the Folium camelliae assamicae and Flos Carthami, add 8 times of water gagings and soaked 1 hour, reflux 1.5 hours is collected volatile oil simultaneously, filtered while hot, and residue adds 6 times of water gagings and refluxed 1 hour, filtered while hot, filtrate merges, and concentrates; Drying under reduced pressure was pulverized 100 mesh sieves and was got extract powder 1; In addition: get Fructus Crataegi, Radix Polygoni Multiflori Preparata and Rhizoma Alismatis and carry 2 times with 70-80% ethanol, each 1.5 hours, medical filtration, filtrate recycling ethanol concentrates, drying under reduced pressure was pulverized 100 mesh sieves and was got extract powder 2, will get extract powder 1 and extract powder 2 mix total extractum; Get volatile oil and spray in the starch, mix homogeneously again with total extract powder mix homogeneously, adds the Pulvis Talci mixing, the dress hard capsule.
Embodiment 3
Get parts by weight of raw materials (kilogram): Fructus Crataegi 5, Fructus Citri Limoniae does 5, Folium camelliae assamicae 3, Radix Polygoni Multiflori Preparata 12, Flos Carthami 2, Rhizoma Alismatis 2, microcrystalline Cellulose 0.3, Pulvis Talci 0.04.
The method of extracting extractum is with embodiment 1.Get the spray drying extract powder, add the microcrystalline Cellulose mixing, add 80% ethanol and granulate in right amount, 60 ℃ of oven dry, put cold, granulate, under stirring, volatile oil is sprayed into fine mist, mix homogeneously, airtight 2 hours, add Pulvis Talci and make lubricant, tabletting, the bag film-coat, promptly.
Embodiment 4
Get parts by weight of raw materials (kilogram): Fructus Crataegi 20, Fructus Citri Limoniae does 20, Folium camelliae assamicae 12, Radix Polygoni Multiflori Preparata 12, Flos Carthami 3, Rhizoma Alismatis 6, soybean oil 44, Cera Flava 2.
The method of extracting extractum is with embodiment 2.Get water content less than 3% spray drying extract powder, add in the soybean oil-beeswax mixture (22: 1, weight ratio) of 50 ℃ of insulations, stir, ground 15 minutes, mistake 120 mesh sieves, 40 ℃ are pressed into soft capsule, promptly.
Claims (3)
1. the health food of a blood fat reducing is characterized in that it is the health food of being made by the following weight parts proportion raw material:
Fructus Crataegi 5-20, Fructus Citri Limoniae does 5-20, Folium camelliae assamicae 3-12, Radix Polygoni Multiflori Preparata 3-12, Flos Carthami 2-6, Rhizoma Alismatis 2-6.
2. the health food of blood fat reducing according to claim 1 is characterized in that the weight portion proportioning of each raw material is:
Fructus Crataegi 10, Fructus Citri Limoniae does 10, Folium camelliae assamicae 6, Radix Polygoni Multiflori Preparata 6, Flos Carthami 3, Rhizoma Alismatis 3.
3. the preparation method of the health food of claim 1 or 2 described blood fat reducing is characterized in that carrying out according to the following steps:
1) dried, the Folium camelliae assamicae and Flos Carthami of Fructus Citri Limoniae was soaked 1-3 hour, reflux 2-4 time, and each 1-4 hour, collection volatile oil, the medicinal liquid filtered while hot, filtrate merges, and concentrates, and drying under reduced pressure is extremely done, and pulverizes the 80-200 order, gets dry extract 1;
2) Fructus Crataegi, Radix Polygoni Multiflori Preparata and Rhizoma Alismatis are used 70-80% ethanol extraction 2-4 time, and each 1-4 hour, medical filtration, filtrate recycling ethanol concentrates, and drying under reduced pressure was pulverized the 80-200 order to doing, and got dry extract 2;
3) dry extract 1 and dry extract 2 are mixed;
Perhaps:
Fructus Crataegi, Fructus Citri Limoniae do, Folium camelliae assamicae, Radix Polygoni Multiflori Preparata, Flos Carthami and Rhizoma Alismatis, soaked 1-3 hour, and reflux 2-4 time, each 1-4 hour, collect volatile oil, the medicinal liquid filtered while hot, the filtrate merging, concentrating under reduced pressure, spray drying gets extractum, and is standby;
4) with above gained extractum, add the microcrystalline Cellulose adjuvant, mixing, 70-90% ethanol system granule, drying, granulate add volatile oil, lubricant, mix homogeneously, compacting is in blocks according to a conventional method, and the bag film-coat gets Film coated tablets;
Perhaps:
Volatile oil adds the microcrystalline Cellulose mix homogeneously, adds the extractum of above gained, and mix homogeneously adds the lubricant mixing, and the dress hard capsule is made hard capsule;
Perhaps:
With above gained extractum, 80 ℃ of drying under reduced pressure to water content less than 3%, add in the soybean oil-beeswax mixture of 40-60 ℃ of insulation with volatile oil, soybean oil, mellisic weight ratio are 22: 1, stir, and grind 10-30 minute, cross 100～200 mesh sieves, 30-60 ℃ is pressed into soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100660482A CN101095769B (en) | 2007-07-19 | 2007-07-19 | Health-care food for reducing blood lipid and method for preparing the same |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007100660482A CN101095769B (en) | 2007-07-19 | 2007-07-19 | Health-care food for reducing blood lipid and method for preparing the same |
Publications (2)
| Publication Number | Publication Date |
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| CN101095769A CN101095769A (en) | 2008-01-02 |
| CN101095769B true CN101095769B (en) | 2010-06-09 |
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| CN2007100660482A Expired - Fee Related CN101095769B (en) | 2007-07-19 | 2007-07-19 | Health-care food for reducing blood lipid and method for preparing the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2011519368A (en) * | 2008-05-01 | 2011-07-07 | アフェクサ ライフ サイエンシーズ インコーポレイテッド | Pharmaceutical composition comprising an extract of yellow ream and bitter tea useful for reducing blood lipid concentration |
| CN102488189B (en) * | 2011-11-11 | 2013-04-24 | 北京燕京中发生物技术有限公司 | Capsule with health-care function of assisting blood lipid reduction and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178681A (en) * | 1996-10-07 | 1998-04-15 | 赵广钧 | Health tea for preventing and curing hyperlipemia |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1178681A (en) * | 1996-10-07 | 1998-04-15 | 赵广钧 | Health tea for preventing and curing hyperlipemia |
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