CN101091803A - Water-soluble bone wax, and preparation method - Google Patents
Water-soluble bone wax, and preparation method Download PDFInfo
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- CN101091803A CN101091803A CN 200610093091 CN200610093091A CN101091803A CN 101091803 A CN101091803 A CN 101091803A CN 200610093091 CN200610093091 CN 200610093091 CN 200610093091 A CN200610093091 A CN 200610093091A CN 101091803 A CN101091803 A CN 101091803A
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- bone wax
- soluble bone
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- -1 polyoxypropylene Polymers 0.000 claims abstract description 35
- 229920001577 copolymer Polymers 0.000 claims abstract description 15
- 229920001451 polypropylene glycol Polymers 0.000 claims abstract description 12
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 238000007334 copolymerization reaction Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 60
- 238000013019 agitation Methods 0.000 claims description 22
- 238000002425 crystallisation Methods 0.000 claims description 22
- 230000008025 crystallization Effects 0.000 claims description 22
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 13
- 229920000136 polysorbate Polymers 0.000 claims description 13
- 229920000053 polysorbate 80 Polymers 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 238000007710 freezing Methods 0.000 claims description 12
- 230000008014 freezing Effects 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 238000000465 moulding Methods 0.000 claims description 12
- 238000012856 packing Methods 0.000 claims description 12
- 238000007789 sealing Methods 0.000 claims description 12
- 238000004659 sterilization and disinfection Methods 0.000 claims description 12
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 11
- 229930195729 fatty acid Natural products 0.000 claims description 11
- 239000000194 fatty acid Substances 0.000 claims description 11
- 208000032843 Hemorrhage Diseases 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000002390 adhesive tape Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 230000003115 biocidal effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000011164 ossification Effects 0.000 claims description 2
- 229920001084 poly(chloroprene) Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 2
- 239000001993 wax Substances 0.000 description 45
- 238000004090 dissolution Methods 0.000 description 8
- 229920001983 poloxamer Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 3
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 3
- 229940112869 bone morphogenetic protein Drugs 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010051937 Osteorrhagia Diseases 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- BQODPTQLXVVEJG-UHFFFAOYSA-N [O].C=C Chemical group [O].C=C BQODPTQLXVVEJG-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a water-bath bone wax. It includes one or two copolymers obtained by making polyoxyethlene and polyoxypropylene undergo the process of copolymerization reaction and emulsifying agent anhydrosorbitol aliphatic ester. Said invention also relates to a kit including the invented water-bath bone wax and a preparation method of said water-bath bone wax.
Description
Technical field
The invention discloses a kind of bone wax.Particularly, the invention discloses the bone hemostatic material that uses in a kind of orthopaedics or the surgery, i.e. water-soluble bone wax with " water solublity ".The invention also discloses the preparation method of this bone wax.
Background technology
Many operation processs and outside damaging the spleen and stomach, the influential point of bone is hemorrhage.In control osteorrhagia or hemostasis, people have researched and developed bone wax and have been administered on the bone as mechanical barrier, can stop blooding effectively.
The bone wax that is used for surgery is usually from the Cera Flava preparation, by with they with the water-insoluble hydrocarbon and vegetable oil is mixed must bone wax.The shortcoming of the bone wax compositions that makes like this is that this wax cohesive when room temperature is very poor, and fragility is big.In addition, the bone wax of the paraffinic base of people's exploitation can not be absorbed by the body, and can retain for a long time in site of administration like this.Therefore, can cause when these waxes are used for human body and infect and the reaction that causes inflammation, surrounding tissue be destroyed, and influenced the regrowth of bone.As the upgrading products of these bone wax, US application No.2003/0095945 discloses the bone wax of the copolymer of oxygen ethylene and oxypropylene.This bone wax can not influence the regrowth of bone, and water-soluble, absorbed the back by health and discharge with urine, and preparation cost is low.
Summary of the invention
On the basis of existing technology, the present invention has further developed a kind of water-soluble bone wax, and compared with prior art, the water solublity of bone wax of the present invention significantly increases.
On the one hand, the present invention relates to a kind of water-soluble bone wax, this water-soluble bone wax comprises:
(i) polyoxyethylene of 69 weight %-99.5 weight % and polyoxypropylene copolymerization and one or both copolymers of obtaining and
The (ii) emulsifying agent sorbitan fatty acid ester of 0.1 weight %-10 weight %.
In a preferred embodiment, non-ionic surface active agent (copolymer) pool Luo Nike (PLURONIC produced for BASF chemical company of the copolymer in the water-soluble bone wax of the present invention
) series of products, preferred molecular weight is 3,000 to 15,000 and polyethylene glycol oxide and the polychloroprene ratio pool Luo Nike between from 0.1: 1 to 2: 1, preferred copolymer is the mixture of pool Luo Nike P85 and F88.
In another preferred embodiment, the sorbitan fatty acid ester in the water-soluble bone wax of the present invention is a tween, preferred Tween 80.
In a preferred embodiment, water-soluble bone wax of the present invention comprises:
(i) the pool Luo Nike of 95 weight %-99.5 weight % and
The (ii) tween of 0.1 weight %-5 weight %.
In a preferred embodiment, water-soluble bone wax of the present invention comprises:
(i) P85 of 65 weight %-95 weight %;
The (ii) F88 of 4 weight %-34 weight %; With
The (iii) sorbitan fatty acid ester of 0.1 weight %-10 weight %.
Water-soluble bone wax of the present invention can further add other hemorrhage, antibiotic, other components such as short osteogenesis agent.
On the other hand, the present invention relates to a kind of test kit, it comprises:
1) aseptic binder;
2) adhesive tape;
3) a pair of sterile gloves;
4) comprise the aseptic bag of water-soluble bone wax of the present invention; With
5) comprise 1), 2), 3), 4) every aseptic bag.
Another aspect the present invention relates to the preparation method of water-soluble bone wax of the present invention, said method comprising the steps of:
1) just polyoxyethylene and polyoxypropylene copolymerization and one or both copolymers of obtaining are heated to about 70 ℃ to 120 ℃ with after the emulsifying agent sorbitan fatty acid ester mixes, and it is liquid that mixture is rendered as;
2) mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly;
3) system temperature is risen to room temperature, make the product molding;
4) divide packing with products therefrom, sealing, high pressure or γShe Xianmiejun sterilization.
Water-soluble bone wax clinical manipulation of the present invention is easy, water soluble and tissue, and histocompatibility is good, the nonirritant inflammatory reaction, and be beneficial to the growth and the healing of osseous tissue.Compare with similar water-soluble bone wax of the prior art, the water solublity of water-soluble bone wax of the present invention significantly improves.That is polyoxyethylene and dissolving and the discharge in vivo of polyoxypropylene copolymer have been increased.
The specific embodiment
Below further illustrate the present invention by specific embodiment.
Embodiment 1. contains the preparation of water-soluble bone wax of the tween of 69 weight % polyoxyethylene and polyoxypropylene copolymer and 10 weight %
With the PLURONIC of 69 grams from BASF
The polysorbate60s of copolymer and 10 grams, and 21 gram hemorrhage water-soluble chitosans put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or the sterilization of ∝ ray sterilizing.
Embodiment 2. contains the preparation of water-soluble bone wax of the tween of 99.5 weight % polyoxyethylene and polyoxypropylene copolymer and 0.5 weight %
With the PLURONIC of 99.5 grams from BASF
The Tween 80 of copolymer and 0.5 gram is put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 3. contains the preparation of water-soluble bone wax of the tween of 99.5 weight % polyoxyethylene and polyoxypropylene copolymer and 0.1 weight %
With the PLURONIC of 99.5 grams from BASF
The Tween 80 and 0.4 bone morphogenetic protein(BMP)-2 of copolymer and 0.1 gram are put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 4. contains the preparation of water-soluble bone wax of the tween of 95 weight % polyoxyethylene and polyoxypropylene copolymer and 5 weight %
With the PLURONIC of 95 grams from BASF
The Tween 80s of copolymer and 5 grams are put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 5. contains the preparation of the water-soluble bone wax of the mixture of pool Luo Nike P85 and F88 and tween
With the pool Luo Nike P85 of 65 grams from BASF, 4 grams are from the pool Luo Nike F88 of BASF, the Tween 80 of 10 grams, and 21 the gram bone morphogenetic protein(BMP)-2 put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 6. contains the preparation of the water-soluble bone wax of the mixture of pool Luo Nike P85 and F88 and tween
With the pool Luo Nike P85 of 95 grams from BASF, 4 grams are from the pool Luo Nike F88 of BASF, 0.1 the Tween 80 of gram, and 0.9 the gram bone morphogenetic protein(BMP)-2 put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 7. contains the preparation of the water-soluble bone wax of the mixture of pool Luo Nike P85 and F88 and tween
From the pool Luo Nike P85 of BASF, 34 grams are from the pool Luo Nike F88 of BASF with 65 grams, and the Tween 80 of 1 gram is put into flask, fully mix by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 8. contains the preparation of water-soluble bone wax of the present invention of the soil temperature 80 of 0.5 weight %
2/1 the mixture of the P85/F88 of 99.5 grams is put into flask with the Tween 80 of 0.5 gram, fully mix, with extremely about 70 ℃ to 120 ℃ of the mixture heated that obtain, be rendered as liquid up to mixture then by mechanical agitation.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Embodiment 9. contains the preparation of water-soluble bone wax of the present invention of the soil temperature 80 of 1 weight %
2/1 the mixture of the P85/F88 of 99 grams is put into flask with the Tween 80 of 1 gram, fully mix, with extremely about 70 ℃ to 120 ℃ of the mixture heated that obtain, be rendered as liquid up to mixture then by mechanical agitation.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
Comparative Examples 10. only contains the preparation of the water-soluble bone wax of polyoxyethylene and polyoxypropylene copolymer
2/1 the mixture of P85/F88 is put into flask, fully mixes by mechanical agitation, then with the mixture heated that obtains to about 70 ℃ to 120 ℃, be rendered as liquid up to mixture.Then the mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ about 30 minutes of low temperature, made its freezing and crystallization rapidly.After crystallization, system temperature is risen to room temperature, make the product molding.Divide packing with products therefrom at last, sealing, high pressure or γShe Xianmiejun sterilization.
The dissolution time of embodiment 11. different water-soluble bone waxes in 37 ℃ of water-baths relatively
The bone wax that obtains in the claim 1,2,3,4,5,6,7 is put into container separately, then each container is placed 37 ℃ of water-baths.More various bone wax fully dissolve the required time, and list comparison in following table 1.
Dissolution time in 37 ℃ of water-baths of table 1
| Embodiment | Polyoxyethylene and polyoxypropylene copolymer (gram) | Emulsifying agent sorbitan fatty acid ester (gram) | Other components (gram) | Dissolution time (min) |
| Embodiment 1 | 69 | 10 | 21 | 2 |
| Embodiment 2 | 99.5 | 0.5 | 0 | 16 |
| Embodiment 3 | 99.5 | 0.1 | 0.4 | 18 |
| Embodiment 4 | 95 | 5 | 0 | 5 |
| Embodiment 5 | 69 | 10 | 21 | 2 |
| Embodiment 6 | 99 | 0.1 | 0.9 | 18 |
| Embodiment 7 | 99 | 1 | 0 | 8 |
As can be seen from the above table, along with the increase of emulsifying agent sorbitan fatty acid ester content in the compositions of the present invention, the dissolution time of compositions in 37 ℃ of water-baths obviously shortens.And other components contents do not have much affect to this.
In addition, the bone wax that obtains in embodiment 8,9 and the Comparative Examples 10 is put into container separately, then container is placed 37 ℃ of water-baths.More various bone wax fully dissolve the required time, and list comparison in following table 2.
Dissolution time in 37 ℃ of water-baths of table 2
| Mixture | Embodiment 8 | Embodiment 9 | Embodiment 10 |
| The mixture of P85/F88+0.5 weight % Tween 80 | The mixture of P85/F88+1.0 weight % Tween 80s | The mixture of P85/F88 | |
| Dissolution time | 17min | 8min | 20min |
As can be seen from the above table, increase along with the content of Tween 80 in the compositions, the very fast shortening of the dissolution time of compositions of the present invention, and the water-soluble bone wax dissolution time of the present invention of adding Tween 80 is significantly shorter than the water-soluble bone wax of the prior art that does not comprise Tween 80.
Although described certain preferred embodiments of the present invention, those skilled in the art should understand that these embodiments are not restrictive, the present invention is not limited to any specific embodiment, because the improvement that may also have, and without doubt, the people who knows the related field of the present invention can expect other embodiments of principle of the present invention.Therefore, scope of the present invention contains with the intention of the essence in the claim, spirit and scope.
Claims (10)
1. water-soluble bone wax, it comprises:
(i) polyoxyethylene of 69 weight %-99.5 weight % and polyoxypropylene copolymerization and one or both copolymers of obtaining and
The (ii) emulsifying agent sorbitan fatty acid ester of 0.1 weight %-10 weight %.
2. water-soluble bone wax according to claim 1, wherein said copolymer are molecular weight 3,000 to 15,000, the pool Luo Nike between polyethylene glycol oxide and the polychloroprene ratio from 0.1 to 1 to 2 to 1.
3. water-soluble bone wax according to claim 1 and 2, wherein said sorbitan fatty acid ester are tween.
4. water-soluble bone wax according to claim 3, wherein said water-soluble bone wax comprises:
(i) the pool Luo Nike of 95 weight %-99.5 weight % and
The (ii) tween of 0.1 weight %-5 weight %.
5. water-soluble bone wax according to claim 1 and 2, wherein said copolymer is the mixture of pool Luo Nike P85 and F88.
6. water-soluble bone wax according to claim 5, wherein said water-soluble bone wax comprises:
(i) P85 of 65 weight %-95 weight %;
The (ii) F88 of 4 weight %-34 weight %; With
The (iii) sorbitan fatty acid ester of 0.1 weight %-10 weight %.
7. water-soluble bone wax according to claim 5, wherein said sorbitan fatty acid ester are Tween 80.
8. water-soluble bone wax according to claim 1, it further comprises other hemorrhage, antibiotic, short osteogenesis agent.
9. test kit, it comprises:
1) aseptic binder;
2) adhesive tape;
3) a pair of sterile gloves;
4) comprise the aseptic bag of the described water-soluble bone wax of claim 1; With
5) comprise 1), 2), 3), 4) every aseptic bag.
10. the preparation method of the described water-soluble bone wax of claim 1, it comprises:
1) with polyoxyethylene and polyoxypropylene copolymerization and one or both copolymers that obtain with after the emulsifying agent sorbitan fatty acid ester mixes, be heated to 70 ℃ to 120 ℃, it is liquid that mixture is rendered as;
2) mixture behind the mechanical agitation mixing is put into immediately-10 ℃ to-150 ℃ low temperature 30 minutes, made its freezing and crystallization rapidly;
3) system temperature is risen to room temperature, make the product molding;
4) divide packing with products therefrom, sealing, high pressure or γShe Xianmiejun sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610093091 CN101091803A (en) | 2006-06-20 | 2006-06-20 | Water-soluble bone wax, and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610093091 CN101091803A (en) | 2006-06-20 | 2006-06-20 | Water-soluble bone wax, and preparation method |
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| Publication Number | Publication Date |
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| CN101091803A true CN101091803A (en) | 2007-12-26 |
Family
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| CN 200610093091 Pending CN101091803A (en) | 2006-06-20 | 2006-06-20 | Water-soluble bone wax, and preparation method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016041443A1 (en) * | 2014-09-18 | 2016-03-24 | 苏州安德佳生物科技有限公司 | Biocompatible hemostatic product and preparation method thereof |
| CN105816905A (en) * | 2016-04-15 | 2016-08-03 | 广州贝奥吉因生物科技有限公司 | Absorbable bone wax with heal-promoting function and preparation method of absorbable bone wax |
| CN106039390A (en) * | 2016-05-27 | 2016-10-26 | 中国人民解放军第七五医院 | Bone wax composition and preparation method thereof |
| CN109893677A (en) * | 2019-03-01 | 2019-06-18 | 广州锐澄医疗技术有限公司 | A kind of absorbable bone wax and preparation method thereof |
| CN109908397A (en) * | 2019-03-01 | 2019-06-21 | 广州锐澄医疗技术有限公司 | A kind of absorbable hemostatic bone wax and preparation method thereof |
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
| US11998653B2 (en) | 2018-01-12 | 2024-06-04 | Beijing Universal Likang Technology Co., Ltd. | Method for treating active bleeding by sequentially applying a biocompatible hemostatic composition and a sealant composition |
-
2006
- 2006-06-20 CN CN 200610093091 patent/CN101091803A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016041443A1 (en) * | 2014-09-18 | 2016-03-24 | 苏州安德佳生物科技有限公司 | Biocompatible hemostatic product and preparation method thereof |
| US10314937B2 (en) | 2014-09-18 | 2019-06-11 | Endoclot Plus Co., Ltd. | Biocompatible hemostatic product and preparation method thereof |
| CN105816905A (en) * | 2016-04-15 | 2016-08-03 | 广州贝奥吉因生物科技有限公司 | Absorbable bone wax with heal-promoting function and preparation method of absorbable bone wax |
| CN105816905B (en) * | 2016-04-15 | 2020-12-18 | 广州贝奥吉因生物科技有限公司 | Absorbable bone wax with healing promoting function and preparation method thereof |
| CN106039390A (en) * | 2016-05-27 | 2016-10-26 | 中国人民解放军第七五医院 | Bone wax composition and preparation method thereof |
| US11213615B2 (en) | 2017-02-28 | 2022-01-04 | EndoClot Plus Co.. Ltd | Composition for submucosal injection, reagent combination, and applications thereof |
| US11998653B2 (en) | 2018-01-12 | 2024-06-04 | Beijing Universal Likang Technology Co., Ltd. | Method for treating active bleeding by sequentially applying a biocompatible hemostatic composition and a sealant composition |
| CN109893677A (en) * | 2019-03-01 | 2019-06-18 | 广州锐澄医疗技术有限公司 | A kind of absorbable bone wax and preparation method thereof |
| CN109908397A (en) * | 2019-03-01 | 2019-06-21 | 广州锐澄医疗技术有限公司 | A kind of absorbable hemostatic bone wax and preparation method thereof |
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Application publication date: 20071226 |