CN101056612B - 含有球形黑孢提取物的化妆品组合物 - Google Patents
含有球形黑孢提取物的化妆品组合物 Download PDFInfo
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- CN101056612B CN101056612B CN200580014966XA CN200580014966A CN101056612B CN 101056612 B CN101056612 B CN 101056612B CN 200580014966X A CN200580014966X A CN 200580014966XA CN 200580014966 A CN200580014966 A CN 200580014966A CN 101056612 B CN101056612 B CN 101056612B
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- Prior art keywords
- acid
- cosmetic
- composition
- extract
- skin
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- 239000001384 succinic acid Substances 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229950000329 thiouracil Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
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Abstract
公开了球形黑孢提取物作为化妆品皮肤有益剂，优选作为亮肤剂单独使用或者与其他皮肤有益剂以及化妆品载体一起联合使用。具有有效亮肤特性的本发明提取物、组合物及方法易于传递至皮肤，并且是商业可得的，具有费用效益，并且可在自然界获得。
Description
发明领域
本发明涉及局部施用至人类皮肤的组合物，该组合物中含有球形黑孢(Nigrospora sphaerica)的提取物，以及使用该组合物处理和调节皮肤的方法，特别是亮肤的方法。
发明背景
许多人都关心他们皮肤的色素沉着程度。例如，有老年斑或雀斑的人可能希望其色斑不明显。另一些人可能希望减轻由日晒引起的皮肤变黑或者希望其自然肤色变浅。为了满足这种需要，进行了大量尝试来开发能减少黑素细胞产生色素的产品。然而，现有的产品不是其效果差就是有不受欢迎的副作用，例如毒性或皮肤刺激。因此，对具有改善整体效果的新亮肤剂(skin lightening agents)存在持续需求，以及需要使它们在生产中易于加工的物质。
本申请至少部分是基于这样的发现，即真菌球形黑孢的提取物具有至少与已知亮肤剂可比的和/或已证实更好的亮肤活性。此前球形黑孢用于化妆的用途是未知的。
发明概述
本发明减少了在先技术的不足，并且部分地，包括含有药学或化妆品学可接受的载体以及球形黑孢提取物的新组合物。本发明组合物含有以重量计0.000001至50％的球形黑孢提取物，并且优选其有机溶剂提取物。优选地，提取物的量以重量计为0.00001％至10％，更优选以重量计0.001％至约7％，甚至更优选以重量计0.01％至5％，以在最小成本下获得最适宜的亮肤效果。
在本发明优选的实施方案中，组合物中进一步包括皮肤有益剂，例如α-羟基酸、β-羟基酸、多羟基酸、氢醌、叔-丁基氢醌、维生素B和/或C衍生物(例如烟酰胺)、二酸、类视黄醇、间苯二酚衍生物、桦木酸、香草酸、桦木酸、水解奶蛋白(hydrolactin)及它们的混合物。还可以包括有机和无机(例如微粉化的金属氧化物)防晒剂。有机防 晒剂可以包括2-羟基-4-甲氧基二苯酮(Benzophenone-3)、二苯甲酮-4(Benzophenone-4)、2，2’-二羟基-4-甲氧基二苯酮(Benzophenone-8)、甲氧基肉桂酸酯、乙基二羟基丙基-PABA、甘油基PABA、水杨酸高 
酯(homosalate)、邻氨基苯甲酸甲酯、氰双苯丙烯酸辛酯(octocrylene)、辛基二甲基PABA、甲氧肉桂酸辛酯(PARSOL MCX)、水杨酸辛酯、PABA、2-苯基苯并咪唑-5-磺酸、水杨酸三乙醇胺(TEAsalicylate)、3-(4-甲基亚苄基)-樟脑、2，4-二羟基二苯酮(Benzophenone-1)、二苯甲酮-2(Benzophenone-2)、二苯甲酮-6(Benzophenone-6)、2-羟基-4-辛氧基二苯酮(Benzophenone-12)、4-异丙基二苯甲酰甲烷、丁基甲氧基二苯甲酰甲烷(PARSOL 1789)、氰双苯丙烯酸乙酯(etocrylene)及它们的混合物。
本发明还包括通过局部施用含有球形黑孢提取物的本发明组合物来调节皮肤的方法。本发明还优选包括涂敷本发明组合物亮肤的方法。
本发明的组合物可用于预防或修复诸如皱纹、松弛以及光损伤之类的皮肤状况。本发明的组合物和方法具有有效亮肤的特性，易于向皮肤递送并具有费用效益，并且从天然来源就可以获得。
发明详述
本发明涉及局部应用至人类皮肤的组合物，该组合物中含有球形黑孢的提取物，以及使用该组合物处理和调节皮肤的方法，特别是亮肤的方法。
黑孢属(Nigrospora)是在土壤、衰弱的植物和种子中广泛存在的一种丝状暗色真菌。黑孢属菌落快速生长、紧密、具绵状毛，起初是白色的，然后变为灰色中带黑色区域及黑色倒色(a black reverse color)。球形黑孢产生分生孢子梗，其用力地排出分生孢子。分生孢子是黑色的、单生的、单细胞的、水平稍微平扁并且具有细的赤道芽孢齿裂(equatorial germ slit)。球形黑孢是黑孢属了解最多的物种，可以在夏威夷岛和环太平洋以及其他的地方发现它们。适用于本发明组合物中的球形黑孢提取物是有机溶剂提取物，例如醇类提取物(甲醇)或者乙酸乙酯提取物。
根据本发明，在组合物中存在的球形黑孢提取物的量以组合物重量计必须为大约0.000001％至大约50％。优选地，提取物的量为约0.00001％至约10％，更优选约0.001％至约7％，还更优选约0.01％至约5％，以在最小成本下获得最适宜的亮肤效果。
本文使用的术语“化妆品组合物”意指局部施用于人类皮肤的组合物。
本文使用的术语“含有”意指包括、由.....构成、由......组成、组成和/或基本上由......组成。
本文使用的术语“皮肤”包括面部、颈部、胸部、背部、手臂、腋窝、手、腿和头部皮肤。
除非在实例中或以其它方式明确指明，否则本说明书中所有表示物质的量或反应条件、物质的物理性质和/或应用的数字应理解为被“约”修饰。组合物中所有的量以重量计，除非另外说明。
应该指出的是，在具体说明任何浓度范围时，任一具体浓度上限可与任一具体浓度下限联合使用。
球形黑孢
根据本发明的提取物是一种来源于真菌界、子囊菌门、黑孢属、球种的物质。在夏威夷岛和环太平洋收获根据本发明使用的球形黑孢。收获后，有机体在第一培养基中生长，从那里分离特定的菌株并移到第二培养基中生长。然后将该球形黑孢从第二培养基中分离，随后提取。根据本发明使用的培养和提取技术是那些微生物领域技术人员已知的或者进一步发展的技术。该具体的供微生物生长的培养方案以及用于制备筛选的提取物的提取方案在下面阐明。该培养和提取方案由下面培养基制备和提取方法的详细描述进一步说明。
示范收集详情(Lead Collection Details)
下表含有关于收集的地理位置、用于分离微生物的培养基以及生长在琼脂隔离皿上微生物的形态学特性的信息。
表1
| 地点/ 说明 | 取样 | 类型 描述 | 盐度 ppt | 回收 培养基 | 回收 温度 | 分离 培养基 | 孢子 形成 | 真菌 质地 |
| 夏威夷岛：珊 瑚礁，碎石和 熔岩(lava tubes) | 浅海 | 红色 | 36 | PDA(马 铃薯淀 粉，右旋 糖) | 25 deg.C | 带有SPC(大 豆，马铃薯， 糖类)的YPG (酵母，葡萄 糖，胨) | FALSE | 致密丛 |
真菌培养的发酵培养基及方案
表2
| 培养基组分 | 数量 |
| 枸橼酸钠 | 8g |
| 棉籽粗粉(Cottonseed meal) | 5g |
| 甘露醇 | 5g |
| 胨 | 4g |
| L-精氨酸 | 1.5g |
向1L海水中加入培养基组分，调节至pH＝4.0±0.2，并在25℃固定液中发酵16天。
提取方案
向整个肉汤培养物中加入大约相等容积的HP-20树脂珠(DIAION商标，Mitsubishi，日本)；振摇2小时，过滤，用相等容积的水洗涤两次；在真空下保持45分钟至干并用相等容积的MeOH(甲醇)提取残余物。其他适合的有机溶剂包括但是不限于乙醇、丙酮、乙酸乙酯、氯仿等等。最后过滤提取物并除去该溶剂。
微生物学鉴定
使用下面的步骤进行微生物鉴定以确定球形黑孢。样品的结果通过Microbial ID Inc.，Newark，Delaware来实现，其包括脂肪酸分布 图以及基因库匹配。
任选的皮肤有益剂
合适的其他皮肤有益剂包括抗衰老、减皱、皮肤增白、祛痤疮和皮脂减少剂。这些的实例包括α-羟基酸、β-羟基酸、多羟基酸、氢醌、叔-丁基氢醌、维生素B和/C衍生物、二酸、类视黄醇、香草酸、桦木酸、尿囊素、胎盘提取物、hydrolactin及间苯二酚衍生物。
化妆品可接受的载体
化妆品可接受的媒介物可作为组合物中皮肤有益成分的稀释剂、分散剂或载体，以使组合物施用于皮肤上时便于分布。
媒介物可为水性、无水的或乳剂。优选地，组合物为水性或乳剂，尤其是油包水或水包油乳剂，优选水包油乳剂。水存在量以重量计可以在5％至99％的范围，优选20％至70％，最佳是40％至70％之间。
除水外，相对挥发性溶剂也可在本发明组合物中作为载体。最优选单羟基C1-C3烷醇类。这些烷醇类包括乙醇、甲醇和异丙醇。单羟基烷醇类的量以重量计可以为1％至70％，优选10％至50％，最佳是在15％至40％之间。
润肤物质(Emollient materials)也可用作化妆品可接受的载体。它们可为硅油和合成酯类形式。润肤剂的量以重量计可在0.1％至50％范围内的任何位置，优选在1％和20％之间。
硅油可分为挥发性和非挥发性的两种。本文使用的术语“挥发性”是指那些在环境温度下具有可测蒸气压的物质。挥发性硅油优选选自含3-9个、优选4-5个硅原子的环状或直链聚二甲基硅氧烷。直链挥发性硅氧烷物质一般在25℃时其粘度小于约5厘沲，而环状挥发性硅氧烷物质粘度典型地小于约10厘沲。可用作润肤物质的非挥发性硅油包括聚烷基硅氧烷、聚烷芳基硅氧烷和聚醚硅氧烷共聚物。本发明可使用的基本非挥发性聚烷基硅氧烷包括例如在25℃时粘度约5厘沲至约25兆厘沲的聚二甲基硅氧烷。其中可用于本发明组合物的优选的非挥发性润肤剂为在25℃时粘度约10厘沲至约400厘沲的聚二甲基硅氧烷。
酯类润肤剂有：
(1)含10-20个碳原子的脂肪酸烯基酯或脂肪酸烷基酯。其实例包括新戊酸异二十碳四烯基(isoarachidyl)酯、isononyl isonanonoate、 豆蔻酸油基酯、硬脂酸油基酯和油酸油基酯。
(2)醚-酯，例如乙氧基化脂肪醇类的脂肪酸酯。
(3)多元醇酯类。乙二醇单脂肪酸酯和乙二醇二脂肪酸酯、二乙二醇单脂肪酸酯和二乙二醇二脂肪酸酯、聚乙二醇(200-6000)单脂肪酸酯和二脂肪酸酯、丙二醇单脂肪酸酯和二脂肪酸酯、聚丙二醇2000单油酸酯、聚丙二醇2000单硬脂酸酯、乙氧基化丙二醇单硬脂酸酯、甘油单和二脂肪酸酯、聚甘油多脂肪酸酯、乙氧基化丙三醇单硬脂酸酯、1，3-丁二醇单硬脂酸酯、1，3-丁二醇二硬脂酸酯、聚氧乙烯多元醇脂肪酸酯、脱水山梨糖醇脂肪酸酯和聚氧乙烯脱水山梨糖醇脂肪酸酯为令人满意的多元醇酯类。
(4)蜡酯类，例如蜂蜡、鲸蜡、肉豆蔻酸十四烷基酯、硬脂酸十八烷基酯和山萮酸二十碳四烯基(arachidyl)酯。
(5)甾醇酯类，其中实例有胆固醇脂肪酸酯。
本发明组合物也可包括作为化妆品可接受载体的含10-30个碳原子的脂肪酸类。该类脂肪酸例如有壬酸、月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、异硬脂酸、羟基硬脂酸、油酸、亚油酸、蓖麻油酸、花生酸、山萮酸和芥酸。
多元醇型保湿剂也可用作本发明组合物中化妆品可接受的载体。保湿剂有助于增加润肤剂的效力，减少脱皮，刺激累积皮屑脱落和改善皮肤感觉。典型的多元醇类包括甘油、聚亚烷基二醇并更优选亚烷基多元醇类及其衍生物，包括丙二醇、二丙二醇、聚丙二醇、聚乙二醇及其衍生物、山梨醇、羟丙基山梨醇、己二醇、1，3-丁二醇、1，2，6-己三醇、乙氧基化丙三醇、丙氧基化丙三醇及其混合物。为了达到最佳效果，保湿剂优选为丙二醇或透明质酸钠。保湿剂的量以组合物重量计可以在0.5％至30％范围内的任何位置，优选在1％和15％之间。
增稠剂也可用作本发明组合物的化妆品可接受载体的部分。典型的增稠剂包括交联丙烯酸酯类(例如Carbopol 982)、疏水改性的丙烯酸酯类(例如Carbopol 1382)、牛磺酸盐聚合物、纤维素衍生物和天然树胶。其中有用的纤维素衍生物有羧甲基纤维素钠、羟丙基甲基纤维素、羟丙基纤维素、羟乙基纤维素、乙基纤维素和羟甲基纤维素。适用于本发明的天然树胶包括瓜尔胶、黄原胶、菌核、角叉菜胶、果胶和这些胶的组合。增稠剂的量以重量计可为0.0001％至5％，通常为 0.001％至1％，最佳是从0.01％至0.5％。
水、溶剂、硅氧烷类、酯类、脂肪酸类、保湿剂和/或增稠剂将共同构成化妆品可接受的载体，用量以重量计为1％至99.9％，优选80％至99％。
油或油性物质可以与乳化剂一起使用以提供油包水乳剂或水包油乳剂，这主要取决于使用乳化剂的平均亲水-亲油平衡值(HLB)。
本发明化妆品组合物中也可使用表面活性剂。表面活性剂的总浓度为组合物重量的0.1％至40％，优选1％至20％，最佳是1％至5％。表面活性剂可选自阴离子表面活性剂、非离子表面活性剂、阳离子表面活性剂和两性表面活性剂。特别优选的非离子表面活性剂为以下那些表面活性剂：每摩尔疏水物与2-100摩尔环氧乙烷或环氧丙烷缩合的C10-C20脂肪醇或酸疏水物；与2-20摩尔的环氧烷缩合的C2-C10烷基酚；乙二醇的单和二脂肪酸酯；脂肪酸甘油单酯；脱水山梨糖醇，单和二C8-C20脂肪酸；嵌段共聚物(环氧乙烷/环氧丙烷)；和聚氧乙烯脱水山梨糖醇以及其组合。烷基聚糖苷类和糖类脂肪酰胺类(如甲基葡萄糖酸酰胺)也是合适的非离子表面活性剂。
优选的阴离子表面活性剂包括肥皂、烷基醚硫酸盐和磺酸盐类、烷基硫酸盐和磺酸盐类、烷基苯磺酸盐类、琥珀酸烷基和二烷基酯磺酸盐、C8-C20酰基羟乙基磺酸盐类、酰基谷氨酸盐类、C8-C20烷基醚磷酸盐类及其组合。
任选的组分
在本发明化妆品组合物中，可任选地加入增塑剂、炉甘石(calamine)、抗氧化剂、螯合剂，还有防晒剂。
其他少量辅助组分也可加入到化妆品组合物中。这些组分可包括着色剂、颜料、遮光剂和香料。这些其他少量辅助组分的量以组合物重量计可在0.001％至最高20％范围内的任何位置。
当用作防晒剂时，可单独或以混合物的形式使用金属氧化物和/或与有机防晒剂组合使用。有机防晒剂的实例包括但不限于下述表格中列出的那些防晒剂。
在化妆品组合物中有机防晒剂的量优选在约0.1重量％至约10重量％的范围，更优选约1重量％至约5重量％。由于其有效性并且市售，优选的有机防晒剂是PARSOL MCX和Parsol 1789。
表3
组合物的用途
根据本发明的真菌提取物以及组合物主要局部应用于人类皮肤的个人护理产品，还可以亮肤，减少皮肤色素沉着的程度，或者甚至是皮肤的色调。
使用时，将少量组合物例如1至5毫升由合适的容器或涂覆器具 施用于皮肤暴露的区域，如有必要，可用手或手指或合适的装置涂布和/或擦于皮肤。
产品形式和包装
本发明化妆品组合物可配制成粘度为4,000-10,000mPas的洗剂、粘度为10,000-20,000mPas的流体乳膏或粘度为20,000-100,000mPas的乳膏或上述剂型。所述组合物可用与其粘度相适应的和顾客有意使用的合适容器包装。例如，洗剂或流体乳膏可用瓶、滚球(roll-ball)涂覆器具或推进剂驱动的气雾剂装置或装有适合手指操作的泵的容器包装。当组合物为乳膏剂时，可简单地储存于不变形瓶或挤压容器中，如管或带盖的广口瓶。当组合物为固体或半固体棒时，可用适宜于将组合物人工或机械推出或挤出的合适容器包装。
相应地，本发明也提供含有本文定义的化妆品可接受组合物的密闭容器。
下面的实施例是举例说明，不是对本发明原理的限制，只是举例说明实现本发明的最好方式。
实施例1
本实施例举例说明使用本发明的球形黑孢提取物减少新生黑色素生成。
在整个实施例中使用的球形黑孢提取物依照在上文描述的方法进行制备。
器官培养法
将8个月大着色猪的废弃皮剃除毛发并充分洗涤以除去碎屑及减少微生物含量。然后将洗净的皮切成约1-mm厚度×75-cm2的皮片，放置在含有青霉素(100-单位/ml)、链霉素(100-ug/ml)、卡那霉素(200-ug/ml)、谷氨酰胺(2-mM)和两性霉素B(fungizone)(0.5-ug/ml)的达尔伯克改良伊格尔培养基(DMEM Cat#1188507)的组织培养瓶中。全部培养瓶在37℃、5％二氧化碳下培养过夜。让该皮在加入黑色素抑制剂前平衡18小时。清除具有葡萄疮、红斑或者不均色素沉着的皮肤区域。
次日早晨，该皮穿孔成直径4-mm的活组织，并转移至96孔组织培养皿中。将含有青霉素(100-单位/ml)、链霉素(100-ug/ml)、谷 氨酰胺(2-mM)、氢化可的松(100-μg/ml)和0.4-μCi/ml14C-硫尿嘧啶(Moravek Biochemicals)的180-微升新鲜DMEM连同20微升的天然提取物(提取物最初溶解在DMSO，亦即二甲基亚砜，并被磷酸盐缓冲生理盐水稀释)一起加入至每一个含有活组织的孔中。所有的培养皿放回保温箱中培育三天。
三天培育期后，通过在室温下用0.1M碳酸盐缓冲溶液在pH10下用自动培养皿洗涤器分别两次洗涤活组织30分钟和两小时，将过剩的没有结合的放射性标记物去除。然后漂白活体组织并通过加入100微升1N NaOH/3％H2O2来溶解，随后在60℃下培养过夜。
一经干燥，向每个孔中加入50微升2N-HCL以重新溶解/中和该样品，随后添加220微升闪烁液(scintillation cocktail)(PackardMicroScint-40)。混合几次该样品以保证均匀分散、密封并使用PackardTopCount闪烁计数器评价放射标记物结合。放射标记物结合的减少说明新黑色素合成的减少。
表4
| 处理 | 浓度 | ％放射标记物的减少＊ |
| 球形黑孢提取物 | 80-ug/ml | 45 |
| 8-ug/ml | 4 | |
| 曲酸 | 1.4-mg/ml (10mM) | 56 |
＊使用斯氏t-检验，统计学上有意义的p值小于0.05。
实施例2
黑色皮肤(MelanoDerm)组织模型方法
黑色皮肤(MelanoDerm)组织等效模型(MEL-300来自Mat Tek，阿什兰，马萨诸塞州)含有从深色皮肤个体获得的黑色素细胞，利用该模型可以证实在猪器官培养中获得的结论。黑色皮肤按照供应商的技术说明书进行培养。
在14天的周期内每两天更换培养基，以最终浓度为每毫升50和100微克向培养介质中加入含有天然提取物的处理物。包括阳性对照， 亦即曲酸，其是已知的亮肤剂。在每次培养基变化期间，废弃培养基的一部分用来分析作为细胞毒性和应激指示剂的乳酸脱氢酶的水平。乳酸脱氢酶的水平决不会在媒介物对照(vehicle control)溶剂(水或乙醇)之上。
使用制造厂商提供的测定法对每块黑色皮肤的黑色素含量进行测定。将每块黑色皮肤在含有20微升蛋白酶K(5mg/ml)的450微升缓冲液(1％SDS，0.05-mM EDTA，10-mM Tris-HCI，pH6.8)中均化，并在45℃培养过夜。第二天，向每个样品中加入50微升碳酸钠(500-mM)以及10微升过氧化氢(30％溶液)，并在80℃培养30分钟，然后冷却。测定顶相的光密度(405-nm)，紧接着用100微升氯仿∶甲醇(2∶1)提取该样品，并离心分离(10,000g)10分钟。测量相对于未处理的或媒介物对照(水或乙醇)的光密度读数。
表5.黑色皮肤等效模型结果
| 处理 | 浓度 | ％放射标记物的减少＊ |
| 曲酸 | 14micro-g/ml (100uM) | 9.5 |
| 球形黑孢提取物 | 50ug/ml | 60.9＊ |
| 100ug/ml | 48.9＊ | |
＊使用斯氏t-检验，统计学上有意义的p值小于0.05。
实施例3
制备本发明范围内的化妆品组合物。
下述表格所示的基质制剂通过搅拌下加热相A成分至70-85℃来制备。在分开的容器中搅拌下加热相B成分至70-85℃。然后，两相均保持在70-85℃的同时将相A加至相B中。在70-85℃搅拌该混合物至少15分钟，然后冷却。
表6
BAL＊指剩余部分
实施例4
本发明范围内的其他化妆品组合物按下述步骤制备：
1.加热相A至80℃
2.于另一容器中加热相B至75℃
3.将B加至A中并在中断加热条件下混合30分钟。
4.在50℃加入相C并混合10分钟。
表7
| 成分 | 重量％ | 相 |
| 水，DI | 剩余部分 | A |
| EDTA二钠 | 0.05 | A |
| 硅酸铝镁 | 0.6 | A |
| 对羟基苯甲酸甲酯 | 0.15 | A |
| Simethicone | 0.01 | A |
| 1，3-丁二醇 | 3.0 | A |
| 羟乙基纤维素 | 0.5 | A |
| 甘油，USP | 2.0 | A |
| 黄原胶 | 0.2 | A |
| 三乙醇胺 | 1.2 | B |
| 硬脂酸 | 3.0 | B |
| 对羟基苯甲酸丙酯NF | 0.1 | B |
| 甘油基羟基硬脂酸酯 | 1.5 | B |
| 硬酯醇 | 1.5 | B |
| 棕榈酸异十八烷基酯 | 6.0 | B |
| C12-15醇辛酸酯 | 3.0 | B |
| 聚二甲基硅氧烷 | 1.0 | B |
| 胆固醇NF | 0.5 | B |
| 脱水山梨醇硬酯酸酯 | 1.0 | B |
| 微粉化二氧化钛 | 5.0 | C |
| 生育酚乙酸酯 | 0.1 | B |
| PEG-100硬脂酸酯 | 2.0 | B |
| 硬酯酰乳酸钠 | 0.5 | B |
| 羟基辛酸 | 0.1 | C |
| 球形黑孢提取物 | 10.0 | C |
| PARSOL MCX | 2.4 | C |
| α-红没药醇(Alpha-bisabolol) | 0.2 | C |
[0101]
实施例5-12
根据实施例3的方法制备一系列本发明范围内的其他组合物并列于下表。
表8
＊乳化剂
Claims (17)
1.一种亮肤的化妆方法，包括向皮肤施用组合物，该组合物含有：
a.以重量计0.01％至50％的球形黑孢提取物；以及
b.化妆品可接受的载体；
其中所述球形黑孢提取物是醇或乙酸乙酯提取物。
2.根据权利要求1的化妆方法，其中所述组合物进一步含有防晒剂。
3.根据权利要求2的化妆方法，其中所述防晒剂是微粉化的金属氧化物。
4.根据前述任一项权利要求的化妆方法，其中以所述组合物重量计含有0.01％至10％的所述提取物。
5.根据权利要求1至3任一项的化妆方法，其中以所述组合物重量计含有0.01％至7％的所述提取物。
6.根据权利要求1至3任一项的化妆方法，其中以所述组合物重量计含有0.01％至5％的所述提取物。
7.根据权利要求1-3任一项的化妆方法，其中所述组合物进一步含有皮肤有益剂，其选自α-羟基酸、β-羟基酸、多羟基酸、氢醌、叔-丁基氢醌、维生素B和/或C衍生物、二酸、类视黄醇、间苯二酚衍生物、香草酸、桦木酸、水解奶蛋白及它们混合物。
8.根据权利要求1-3任一项的化妆方法，其中所述组合物进一步含有有机防晒剂，其选自2-羟基-4-甲氧基二苯酮、5-苯甲酰基-4-羟基-2-甲氧基苯磺酸、2，2’-二羟基-4-甲氧基二苯酮、甲氧基肉桂酸酯、乙基二羟基丙基-PABA、甘油基PABA、水杨酸高酯、邻氨基苯甲酸甲酯、氰双苯丙烯酸辛酯、辛基二甲基PABA、甲氧肉桂酸辛酯、水杨酸辛酯、PABA、2-苯基苯并咪唑-5-磺酸、水杨酸三乙醇胺、3-(4-甲基亚苄基)-樟脑、2，4-二羟基二苯酮、双(2，4-二羟基苯基)甲酮、双(2-羟基-4-甲氧基苯基)甲酮、2-羟基-4-辛氧基二苯酮、4-异丙基二苯甲酰甲烷、丁基甲氧基二苯甲酰甲烷、氰双苯丙烯酸乙酯及它们的混合物。
9.根据权利要求1的方法，其中所述醇是甲醇、乙醇或其混合物。
10.化妆品组合物，含有：
a.以重量计0.01％至50％的球形黑孢提取物，其中所述球形黑孢提取物是醇或乙酸乙酯提取物；和
b.化妆品可接受的载体；以及
c.皮肤有益剂和/或防晒剂；其中皮肤有益剂选自α-羟基酸、β-羟基酸、多羟基酸、氢醌、叔-丁基氢醌、维生素B和/或C衍生物、二酸、类视黄醇、间苯二酚衍生物、香草酸、桦木酸、水解奶蛋白及它们的混合物。
11.根据权利要求10的化妆品组合物，其中所述醇是甲醇、乙醇或其混合物。
12.根据权利要求10的化妆品组合物，其中以组合物重量计含有0.01％至10％的所述提取物。
13.根据权利要求10的化妆品组合物，其中以组合物重量计含有0.01％至7％的所述提取物。
14.根据权利要求10的化妆品组合物，其中以组合物重量计含有0.01％至5％的所述提取物。
15.根据权利要求10的化妆品组合物，其中所述防晒剂包括微粉化的金属氧化物。
16.根据权利要求10的化妆品组合物，其中所述组合物含有有机防晒剂，其选自2-羟基-4-甲氧基二苯酮、5-苯甲酰基-4-羟基-2-甲氧基苯磺酸、2，2’-二羟基-4-甲氧基二苯酮、甲氧基肉桂酸酯、乙基二羟基丙基-PABA、甘油基PABA、水杨酸高
酯、邻氨基苯甲酸甲酯、氰双苯丙烯酸辛酯、辛基二甲基PABA、甲氧肉桂酸辛酯、水杨酸辛酯、PABA、2-苯基苯并咪唑-5-磺酸、水杨酸三乙醇胺、3-(4-甲基亚苄基)-樟脑、2，4-二羟基二苯酮、双(2，4-二羟基苯基)甲酮、双(2-羟基-4-甲氧基苯基)甲酮、2-羟基-4-辛氧基二苯酮、4-异丙基二苯甲酰甲烷、丁基甲氧基二苯甲酰甲烷、氰双苯丙烯酸乙酯及它们的混合物。
17.根据权利要求16的化妆品组合物，其中以化妆品组合物重量计在化妆品组合物中有机防晒剂的含量范围是0.1％至10％。
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| US10/843,489 | 2004-05-11 | ||
| PCT/EP2005/004494 WO2005117809A2 (en) | 2004-05-11 | 2005-04-22 | Cosmetic compositions containing nigrospora sphaerica extracts |
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| JP (1) | JP4679576B2 (zh) |
| KR (1) | KR101220055B1 (zh) |
| CN (1) | CN101056612B (zh) |
| AT (1) | ATE399533T1 (zh) |
| AU (1) | AU2005249182B2 (zh) |
| BR (1) | BRPI0509821B1 (zh) |
| CA (1) | CA2564836C (zh) |
| DE (1) | DE602005007893D1 (zh) |
| ES (1) | ES2308534T3 (zh) |
| MX (1) | MXPA06012994A (zh) |
| PL (1) | PL1755549T3 (zh) |
| RU (1) | RU2353347C2 (zh) |
| TW (1) | TWI378808B (zh) |
| WO (1) | WO2005117809A2 (zh) |
| ZA (1) | ZA200608618B (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8496948B2 (en) * | 2009-12-02 | 2013-07-30 | Bath And Body Works Brand Management, Inc. | Topical skin composition comprising mineral yeast ferments |
| RU2450836C1 (ru) * | 2011-03-15 | 2012-05-20 | Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" | Комбинированная мазевая композиция для уменьшения интенсивности локальной гиперпигментации кожи |
| CN113303342A (zh) * | 2021-05-19 | 2021-08-27 | 湖南科技学院 | 银杏内生球黑孢菌生物农药及其制备方法与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616247A (en) * | 1967-12-13 | 1971-10-26 | Ici Ltd | Production of griseofulvin |
| US4284720A (en) * | 1979-01-12 | 1981-08-18 | Schering, A.G. | Process for the preparation of 19-hydroxy steroids of the androstane and pregnane series |
| US4845027A (en) * | 1982-10-13 | 1989-07-04 | Minnesota Mining And Manufacturing Company | Fluorometric assay of allergic reactions |
| US4963356A (en) * | 1982-10-13 | 1990-10-16 | Minnesota Mining And Manufacturing Company | Stable antigenic extracts methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3701787A (en) * | 1969-03-05 | 1972-10-31 | American Cyanamid Co | Preparation of 5,6-dihydro-5-hydroxy-6-propenyl-2-pyrone by fermentation and derivatives thereof |
| EP0112603B2 (en) * | 1982-11-10 | 1992-03-18 | Imperial Chemical Industries Plc | Aphidicolane derivatives, their preparation and pharmaceutical compositions comprising them |
| JPH0912471A (ja) * | 1995-06-29 | 1997-01-14 | Noevir Co Ltd | 皮膚外用剤 |
| PE20001145A1 (es) * | 1998-09-10 | 2000-10-25 | American Cyanamid Co | Mezclas fungicidas |
| JP2000146844A (ja) * | 1998-11-17 | 2000-05-26 | Nichirei Corp | ポリフェノールオキシダーゼ類の酵素活性を測定するための器具、その製造方法及びそれを用いたポリフェノールオキシダーゼ類の酵素活性の測定方法 |
| JP4009678B2 (ja) * | 2000-03-03 | 2007-11-21 | 独立行政法人産業技術総合研究所 | 糸状菌を用いるダイオキシン分解方法、ダイオキシン処理剤及びダイオキシン分解性糸状菌 |
| FR2811890B1 (fr) * | 2000-07-21 | 2003-05-02 | Oreal | Composition a base d'enzymes pour la decoloration des fibres keratiniques et procede de decoloration |
| MXPA05007535A (es) * | 2003-01-21 | 2005-09-21 | Pharmacia & Upjohn Co Llc | Un procedimiento para producir acidos 19-nor-10(-carboxilicos mediante oxidacion fungica de (6-pregnanos-6sustituidos. |
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2004
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- 2005-04-22 AU AU2005249182A patent/AU2005249182B2/en not_active Ceased
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616247A (en) * | 1967-12-13 | 1971-10-26 | Ici Ltd | Production of griseofulvin |
| US4284720A (en) * | 1979-01-12 | 1981-08-18 | Schering, A.G. | Process for the preparation of 19-hydroxy steroids of the androstane and pregnane series |
| US4845027A (en) * | 1982-10-13 | 1989-07-04 | Minnesota Mining And Manufacturing Company | Fluorometric assay of allergic reactions |
| US4963356A (en) * | 1982-10-13 | 1990-10-16 | Minnesota Mining And Manufacturing Company | Stable antigenic extracts methods |
| US4845027B1 (en) * | 1982-10-13 | 1994-05-10 | Biowhittaker Inc | Fluorometric assay of allergic reactions |
Non-Patent Citations (1)
| Title |
|---|
| US 3616247 A, |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005249182B2 (en) | 2007-05-03 |
| JP4679576B2 (ja) | 2011-04-27 |
| TW200603837A (en) | 2006-02-01 |
| RU2006139961A (ru) | 2008-06-10 |
| EP1755549B1 (en) | 2008-07-02 |
| WO2005117809A3 (en) | 2006-05-26 |
| RU2353347C2 (ru) | 2009-04-27 |
| MXPA06012994A (es) | 2006-12-20 |
| DE602005007893D1 (de) | 2008-08-14 |
| AU2005249182A1 (en) | 2005-12-15 |
| EP1755549A2 (en) | 2007-02-28 |
| CN101056612A (zh) | 2007-10-17 |
| CA2564836C (en) | 2016-09-20 |
| BRPI0509821B1 (pt) | 2015-10-20 |
| CA2564836A1 (en) | 2005-12-15 |
| BRPI0509821A (pt) | 2007-09-18 |
| WO2005117809A2 (en) | 2005-12-15 |
| ES2308534T3 (es) | 2008-12-01 |
| PL1755549T3 (pl) | 2008-12-31 |
| TWI378808B (en) | 2012-12-11 |
| US20050255056A1 (en) | 2005-11-17 |
| US7396534B2 (en) | 2008-07-08 |
| ATE399533T1 (de) | 2008-07-15 |
| KR101220055B1 (ko) | 2013-01-08 |
| JP2007537173A (ja) | 2007-12-20 |
| KR20070011474A (ko) | 2007-01-24 |
| ZA200608618B (en) | 2008-06-25 |
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