CN101053612B - External applied traditional Chinese medicine vagina cleaning agent for curing gynecopathy and vagina cleaning ointment thereof - Google Patents
External applied traditional Chinese medicine vagina cleaning agent for curing gynecopathy and vagina cleaning ointment thereof Download PDFInfo
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- CN101053612B CN101053612B CN2007100798416A CN200710079841A CN101053612B CN 101053612 B CN101053612 B CN 101053612B CN 2007100798416 A CN2007100798416 A CN 2007100798416A CN 200710079841 A CN200710079841 A CN 200710079841A CN 101053612 B CN101053612 B CN 101053612B
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal pudenda-cleaning formulation and pudenda-cleaning cream, the prescription comprising: golden-rim winter daphne 50-200g, corktree bark 50-200g, cnidium fruit 50-200g, Chinese goldthread 30-100g, scutellarta root 50-200g, rhubarb 30-100g. The advantages of the invention lie in that the combination of the herbs has a sterilizing and disinfecting function in a certain degree, which can be used for treating eczema and itching in pudenda and normal or menstruation period nursery. In the preparation of pudenda-cleaning cream, hibitane 1.0 g, carbomer 5-20g, propylene glycol or glycerol 100-300g are added, the cream can reduce the stimulation to the mucosa and skin during the sterilization process. The invention is convenient in use, easy to clean, comfortable during application and will not pollute the clothes.
Description
Technical field
Chinese medicine pudendal lotion and clean the moon thereof of the present invention relates to a kind of gynecological external use coagulate cream.
Background technology
Gynecological inflammation is a notion that category is very wide, this disease be not only married women have this disease and unmarried women and the grand climacteric women many examples of suffering from this disease are also arranged.It is clinical multiple performance, comprise that urine is unusual, pruritus, unusual, the stomach-ache of secretions, this has brought more difficulty with regard to the treatment of giving the patient, the existence of these inflammation such as untimely treatment and the prevention diseases such as causing urethritis, pelvic inflammatory disease of might showing effect repeatedly.
As everyone knows, gynecological inflammation mostly with damp and hot inequality, qi depression to blood stasis links to each other, secular damp and hot inequality and cause human endocrine disorderly relevant with the intrusion of pathogenic bacteria, pathogen, obviously will tackle the problem at its root, general medicine is difficult to accomplish, our outbreak repeatedly of often saying that Here it is.
Motherland's traditional medicine is started with from dialectical, and treating both the principal and secondary aspects of a disease, brainstrust think that the treatment of gynecological inflammation should be with eliminating inflammation and expelling toxin, pathogenic fire reducing is treating stranguria, the sharp Wen Weizhu of promoting flow of QI and blood, heat clearing away, after curing with the method, and seldom recurrence basically, and as you know, the recurrence of inflammation has huge infringement to health.
Chinese medicine have the theory of " inner disease outer treat ", and traditional inner disease outer therapy has patch, fumigation and wash method, moxibustion to control, bathe foot etc.
But because conventional dosage forms technology is coarse, particularly the substrate controlled of patch, fumigation and wash method, moxibustion is selected for use unreasonablely, uses inconvenience, often causes skin allergy, loses the market competitiveness gradually.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine pudendal lotion of gynecological external use and the dosage form that clean the moon coagulates cream thereof, this Chinese medicine pudendal lotion has the effect of sterilizing cleaning gynecological pudendum, and this clean the moon coagulates the skin irritation of bringing when cream can suitably reduce the Chinese medicine sterilization.
Technical scheme of the present invention is:
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material: composition of raw materials: VC.Aureomariginatn 50-200g, Cortex Phellodendri 50-200g, Fructus Cnidii 50-200g, Radix Sophorae Flavescentis 50-200g, Rhizoma Coptidis 30-100g, Radix Scutellariae 50-200g, Radix Et Rhizoma Rhei 30-100g.
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material: VC.Aureomariginatn 50-200g, Cortex Phellodendri 50-200g, Fructus Cnidii 50-200g, Radix Sophorae Flavescentis 50-200g, Rhizoma Coptidis 30-100g, Radix Scutellariae 50-200g, Radix Et Rhizoma Rhei 30-100g; Hibitane 0-1.0g, sodium benzoate 0-1.5g, Oleum menthae 0-1.5ml, Mentholum 0-0.5g; The carbomer of Tween-80 0-8.0ml, 5-20g; 100-300g solvent, solvent can be propylene glycol or glycerol.
VC.Aureomariginatn has higher medical value.The medicinal component of VC.Aureomariginatn mainly is " daphnin ".Its flower, but leaf, dermatome people's medicine all.Property is sweet, cold, nontoxic.Eliminating inflammation and expelling toxin is arranged, and the promoting the circulation of blood diuretic goes swollen pain relieving, the effect that the blood that looses is lived and become silted up.Can control innominate toxic swelling, treat skin ulcer, mastitis fester, tooth laryngalgia, gastropathy etc.The source of VC.Aureomariginatn can be with reference to " CN1135914.5 Jinbianruixiang flower perfume and process for super-critical extracting thereof ".
Fructus Cnidii: meridian distribution of property and flavor: hot, bitter, temperature, slightly poisonous.Return kidney channel.Effect cures mainly: warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, external treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Hibitane has another name called chlorhexidine, is the biguanides disinfectant, is all very low safe disinfection agent of a kind of toxicity, corrosivity and zest.Be external broad-spectrum antibacterial, bactericide, Gram-negative and gram-positive bacterium are all had very strong antibacterial, sterilizing ability.Domestic production has two chlorhexidine acetates and two chlorhexidine hydrochloride, and is external with two chlorhexidine gluconates.The back is a kind of to be better than preceding two kinds.Hibitane is colourless or white powder, and odorlessness is non-hygroscopic, disinfective action good, with low cost, stable in properties, easy to use, synthetic simple, belongs to low effect disinfectants.Can be widely used in the sterilization of skin mucosa, wound surface and urinary organs.
Carbomer (carbomer) is applied in external emulsion, cream frost, the gel.Carbomer under the neutral environment (carbomer) system is fabulous gel-type vehicle, and is apparent sparkling and crystal-clear, and feel is lubricated, is fit to very much be used for preparing frost or gel.
The invention has the advantages that: select the combination of VC.Aureomariginatn, Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, Chinese medicine pudendal lotion as gynecological external use, experimental data shows that this combination has certain sterilization, antiinflammation, this Chinese medicine pudendal lotion has the effect of sterilizing cleaning gynecological pudendum, be mainly used in the eczema of women's pudendum and send the disease of itching, also can be used at ordinary times or menstruation care, this clean the moon coagulates the gel that cream further increases hibitane and chooses, the stimulation to mucosa, skin that brings when can suitably reduce the Chinese medicine sterilization.That the present invention also has is easy to use, the impression is comfortable, easily wash, advantage such as pollution clothes not.
The specific embodiment
Embodiment 1,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 50g, Cortex Phellodendri 50g, Fructus Cnidii 50g, Radix Sophorae Flavescentis 50g, Rhizoma Coptidis 30g, Radix Scutellariae 50g, Radix Et Rhizoma Rhei 30g;
Preparation technology:
The preparation of VC.Aureomariginatn extractum: depletion limit winter daphne, dry to moisture for 50 ℃ and be lower than 5%, pulverize 10 mesh sieves and obtained middle coarse powder; Add the alcohol reflux 3 times of volumetric concentration 65% in the ratio of 3 times of weight of golden-rimmed winter daphne, filter, filtrate merges, and reclaims ethanol, relative density is 1.15 VC.Aureomariginatn extractum when being evaporated to 55 ℃, places room temperature, and is standby;
Get Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, the decocting that adds 6 times of weight multiples respectively boils three times, 1.5 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, relative density was 1.15 clear paste when filtration was concentrated into 70 ℃, added VC.Aureomariginatn extractum, adding ethanol makes and contains alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate recycling ethanol is to there not being the alcohol flavor, add water 200g stirring and dissolving, restock water to the total amount of all substances is the Chinese medicine pudendal lotion that 1000g obtains gynecological external use.
Embodiment 2,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 90g, Cortex Phellodendri 60g, Fructus Cnidii 90g, Radix Sophorae Flavescentis 60g, Rhizoma Coptidis 60g, Radix Scutellariae 60g, Radix Et Rhizoma Rhei 60g; All the other are with embodiment 1.
Embodiment 3,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 200g, Cortex Phellodendri 200g, Fructus Cnidii 200g, Radix Sophorae Flavescentis 200g, Rhizoma Coptidis 100g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g; All the other are with embodiment 1.
Embodiment 4,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 100g, Cortex Phellodendri 100g, Fructus Cnidii 100g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 50g, Radix Scutellariae 100g, Radix Et Rhizoma Rhei 50g; All the other are with embodiment 1.
Embodiment 5,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 50-200g, Cortex Phellodendri 50-200g, Fructus Cnidii 50-200g, Radix Sophorae Flavescentis 50-200g, Rhizoma Coptidis 30-100g, Radix Scutellariae 50-200g, Radix Et Rhizoma Rhei 30-100g; All the other are with embodiment 1.
Embodiment 6,
The Chinese medicine pudendal lotion of gynecological external use is the medicament of being made by following raw material:
Composition of raw materials: also add hibitane 1.0g, sodium benzoate 1.5g, Oleum menthae 1.5ml, Mentholum 0.5g, Tween-80 8.0ml;
Preparation technology:
After filtrate recycling ethanol to nothing alcohol flavor operation finishes, add Tween-80 8.0ml again, add after the water 200g stirring and dissolving, add hibitane, sodium benzoate, Mentholum, Oleum menthae again, restock water to the total amount of all substances is the Chinese medicine pudendal lotion that 1000g obtains gynecological external use.
All the other repeat embodiment 1,2,3,4,5 respectively; Obtain the Chinese medicine pudendal lotion of five kinds of gynecological external uses.
Embodiment 7,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material:
Composition of raw materials: the carbomer that also adds 20g; 300g solvent, solvent can be propylene glycol.
Preparation technology:
Get the carbomer of 20g, add 300g propylene glycol swelling after, each 1000g of the Chinese medicine pudendal lotion of five kinds of gynecological external uses that provide with embodiment 6 mix homogeneously respectively respectively obtains five kinds of Chinese medicine pudendal lotions that coagulate the gynecological external use that the cream form exists with clean the moon respectively; All the other repeat embodiment 1,2,3,4,5,6 respectively.
Embodiment 8,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material:
Composition of raw materials: the carbomer that also adds 20g; 300g solvent, solvent can be glycerol.
Preparation technology:
Get the carbomer of 20g, add 300g glycerol swelling after, each 1000g of the Chinese medicine pudendal lotion of five kinds of gynecological external uses that provide with embodiment 6 mix homogeneously respectively respectively obtains five kinds of Chinese medicine pudendal lotions that coagulate the gynecological external use that the cream form exists with clean the moon respectively; All the other repeat embodiment 1,2,3,4,5,6 respectively.
Embodiment 9,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, and the carbomer consumption in the composition of raw materials is 5g; All the other repeat each scheme among the embodiment 7,8 respectively.
Embodiment 10,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, and the carbomer consumption in the composition of raw materials is 15g; All the other repeat each scheme among the embodiment 7,8 respectively.
Embodiment 11,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 90g, Cortex Phellodendri 60g, Fructus Cnidii 90g, Radix Sophorae Flavescentis 60g, Rhizoma Coptidis 60g, Radix Scutellariae 60g, Radix Et Rhizoma Rhei 60g; Hibitane 1.0g, sodium benzoate 1.5g, Oleum menthae 1.5ml, Mentholum 0.5g; The carbomer of Tween-80 8.0ml, 20g; 300g solvent, solvent can be propylene glycol or glycerol;
Preparation technology:
The preparation of VC.Aureomariginatn extractum: depletion limit winter daphne, dry to moisture for 50 ℃ and be lower than 5%, pulverize 10 mesh sieves and obtained middle coarse powder; Add the alcohol reflux 3 times of volumetric concentration 65% in the ratio of 3 times of weight of golden-rimmed winter daphne, filter, filtrate merges, and reclaims ethanol, relative density is 1.15 VC.Aureomariginatn extractum when being evaporated to 55 ℃, places room temperature, and is standby;
Get Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, the decocting that adds 6 times of weight multiples respectively boils three times, 1.5 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, relative density was 1.15 clear paste when filtration was concentrated into 70 ℃, add VC.Aureomariginatn extractum, add ethanol and make and contain the alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and addition polymerization Pyrusussuriensis ester-808.0ml adds after the water 200g stirring and dissolving again, add hibitane again, sodium benzoate, Mentholum, it is stand-by that Oleum menthae, restock water to the total amount of all substances are that 400g obtains Chinese medicine extraction liquid;
Get the carbomer of 20g, add 300g propylene glycol or glycerol swelling after, slowly splash into Chinese medicine extraction liquid, supplementing water to the total amount of all substances is that 1000g obtains clean the moon and coagulates cream.
All the other are with embodiment 1.
Embodiment 12,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 100g, Cortex Phellodendri 100g, Fructus Cnidii 100g, Radix Sophorae Flavescentis 100g, Rhizoma Coptidis 50g, Radix Scutellariae 100g, Radix Et Rhizoma Rhei 50g; Hibitane 1.0g, sodium benzoate 1.5g, Oleum menthae 1.5ml, Mentholum 0.5g; The carbomer of Tween-80 8.0ml, 20g; 300g solvent, solvent can be propylene glycol or glycerol;
All the other are with embodiment 11.
Embodiment 13,
Clean the moon coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material:
Composition of raw materials: VC.Aureomariginatn 100g, Cortex Phellodendri 100g, Fructus Cnidii 80g, Radix Sophorae Flavescentis 80g, Rhizoma Coptidis 60g, Radix Scutellariae 60g, Radix Et Rhizoma Rhei 60g;
Hibitane 0.3g, sodium benzoate 0.5g, Oleum menthae 0.5ml, Mentholum 0.3g; The carbomer of Tween-80 5.0ml, 15g; 200g solvent, solvent can be propylene glycol or glycerol;
Preparation technology:
The preparation of VC.Aureomariginatn extractum: depletion limit winter daphne, dry to moisture for 50 ℃ and be lower than 5%, pulverize 10 mesh sieves and obtained middle coarse powder; Add the alcohol reflux 3 times of volumetric concentration 65% in the ratio of 3 times of weight of golden-rimmed winter daphne, filter, filtrate merges, and reclaims ethanol, relative density is 1.15 VC.Aureomariginatn extractum when being evaporated to 55 ℃, places room temperature, and is standby;
Get Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, the decocting that adds 6 times of weight multiples respectively boils three times, 1.5 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, relative density was 1.15 clear paste when filtration was concentrated into 70 ℃, add VC.Aureomariginatn extractum, add ethanol and make and contain the alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate recycling ethanol adds Tween-80 again to there not being the alcohol flavor, adds after the water 200g stirring and dissolving, add hibitane again, sodium benzoate, Mentholum, it is stand-by that Oleum menthae, restock water to the total amount of all substances are that 400g obtains Chinese medicine extraction liquid;
Get carbomer, add propylene glycol or glycerol swelling after, slowly splash into Chinese medicine extract, supplementing water to the total amount of all substances is that 1000g obtains clean the moon and coagulates cream.
Embodiment 14,
The clean the moon of Sheng Deweimei coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material: VC.Aureomariginatn 50g, Cortex Phellodendri 50g, Fructus Cnidii 50g, Radix Sophorae Flavescentis 50g, Rhizoma Coptidis 30g, Radix Scutellariae 50g, Radix Et Rhizoma Rhei 30-100g;
Hibitane 0.7g, sodium benzoate 1.2g, Oleum menthae 0.8ml, Mentholum 0.1g; The carbomer of Tween-80 4.0ml, 6g; 100g solvent, solvent can be propylene glycol or glycerol.
All the other are with embodiment 13.
Embodiment 15,
The clean the moon of Sheng Deweimei coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material: VC.Aureomariginatn 200g, Cortex Phellodendri 200g, Fructus Cnidii 200g, Radix Sophorae Flavescentis 200g, Rhizoma Coptidis 100g, Radix Scutellariae 200g, Radix Et Rhizoma Rhei 100g;
Hibitane 0.3g, sodium benzoate 0.5g, Oleum menthae 0.9ml, Mentholum 0.3g; The carbomer of Tween-80 2.0ml, 10g; 90g solvent, solvent can be propylene glycol or glycerol.
All the other are with embodiment 13.
Embodiment 16,
The clean the moon of Sheng Deweimei coagulates the Chinese medicine pudendal lotion that cream is a kind of gynecological external use, is the medicament of being made by following raw material: VC.Aureomariginatn 50-200g, Cortex Phellodendri 50-200g, Fructus Cnidii 50-200g, Radix Sophorae Flavescentis 50-200g, Rhizoma Coptidis 30-100g, Radix Scutellariae 50-200g, Radix Et Rhizoma Rhei 30-100g;
Hibitane 0-1.0g, sodium benzoate 0-1.5g, Oleum menthae 0-1.5ml, Mentholum 0-0.5g; The carbomer of Tween-80 0-8.0ml, 0-20g; 0-300g solvent, solvent can be propylene glycol or glycerol.
All the other are with embodiment 13.
Embodiment 17,
The model of the carbomer that the present invention adopts can be a carbomer (Carbomer) 940; Viscosity: 40000～60000mPa.s.
All the other repeat the embodiment of each the example use carbomer among the embodiment 1-16 respectively.
Embodiment 18,
The model of the carbomer that the present invention adopts can be a carbomer (Carbomer) 941; Viscosity: 4000～11000mPa.s.
All the other repeat the embodiment of each the example use carbomer among the embodiment 1-16 respectively.
Embodiment 19,
The model of the carbomer that the present invention adopts can be a carbomer (Carbomer) 934; Viscosity: 30000～40000mPa.s.
All the other repeat the embodiment of each the example use carbomer among the embodiment 1-16 respectively.
Embodiment 20,
The model of the carbomer that the present invention adopts can be a carbomer (Carbomer) 980.Viscosity: 40000～80000mPa.s.
All the other repeat the embodiment of each the example use carbomer among the embodiment 1-16 respectively.
Embodiment 21,
The model of the carbomer that the present invention adopts can be other carbomers (Carbomer) that are fit to.All the other repeat the embodiment of each the example use carbomer among the embodiment 1-16 respectively.
Below be experimental example:
Bactericidal action of the present invention is to be finished by the combination of VC.Aureomariginatn, Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, in order to bring into play the bonded advantage of the germ-resistant complementation of Chinese medicine and western medicine, also suitably increases hibitane.And the suitable fluctuation in certain scope of the consumption of VC.Aureomariginatn, Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei should not influence bactericidal effect.Should not be confined to a specific prescription from normal judgement bactericidal effect of the present invention.
Get the Chinese medicine pudendal lotion of the Chinese medicine extraction liquid A of VC.Aureomariginatn of the present invention, Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei below respectively as gynecological external use, with and corresponding clean the moon coagulate paste formulation B1, B2, B3 as experimental subject.Chinese medicine extraction liquid A, clean the moon coagulate paste formulation B corresponding respective embodiments respectively.
The sample that participates in experiment has: Chinese medicine extraction liquid A and clean the moon coagulate paste formulation B thin up respectively, and guarantee content 0.6 gram crude drug/milliliter.JIEERYIN XIYE, grace prestige generation prosperous pharmaceutical Co. Ltd in Chengdu produces (lot number 060303-5).
Animal: Kunming mouse, body weight 20 ± 2 grams, Wistar rat body weight 180 ± 20 grams, Cavia porcellus, body weight 300 ± 30 grams are male and female half and half.Rabbit, female, 2.2 ± 0.5 kilograms of body weight.Laboratory animal room provides by medical faunae center, Jiangxi.
Bacterial strain: testing required bacterial strain provides by medical college microbial room of University Of Nanchang.
Method and result
Mice dimethylbenzene brings out the ear swelling test: 50 of mices, divide equally 5 groups.Medication group coating once, 0.1 milliliter in every ear, matched group is coated with the equivalent lyase.Be coated with dimethylbenzene 0.05ml/ ear to mouse right ear after 1 hour, left ear compares, and puts to death animal after 15 minutes, with 6 millimeters card punch of diameter the auricle of ears with the position homalographic is taken off, and with a left side, the difference of auris dextra weight is the swelling degree, the results are shown in Table 1.Data show that xylol causes mice ear inhibitory action is all arranged.Action intensity is similar to the JIEERYIN with isoconcentration.
The influence of the clean cloudy gel B1 of table 1, B2, B3, Chinese medicine extraction liquid A xylol induced mice ear swelling
| Group dosage (g) n swelling degree (mg) suppression ratio (%) |
| Clean cloudy gel B1 50 10 7.88 ± 1.25** 35.67 clean cloudy gel B2 25 10 8.50 ± 1.69** 30.61 clean cloudy gel B3 10 10 9.90 ± 1.97* 19.18 Chinese medicine extraction liquid A 25 10 8.92 ± 1.97* 27.20 JIEERYIN 25 10 8.50 ± 2.67** 30.61 matched groups-10 12.25 ± 2.60- |
Compare * P＜0.05 * * P＜0.01 (down together) with matched group
The test of rat Ovum Gallus domesticus album pedal swelling: 50 of rats, divide equally 5 groups.Medication group coating (0.1ml/100g) is after 1 hour, and each is organized right back sufficient plantar subcutaneous injection fresh albumen 0.05ml matched group and is coated with the equivalent lyase.Measure with capillary tube measurement by magnification method and to cause scorching back every two hours sufficient volume, about sufficient volume difference be the swelling degree.The results are shown in Table 2.50% clean cloudy gel and can obviously suppress foot swelling (P＜0.05) due to the Ovum Gallus domesticus album, sustainable 2 hours of inhibition time, action intensity is to similar with the isoconcentration JIEERYIN.Sustainable 6 hours of its inhibition time of 100% coagulant liquid.
The clean cloudy gel B1 of table 2, B2, B3, Chinese medicine extraction liquid A are to the influence of rat Ovum Gallus domesticus album pedal swelling (x ± s)
Bacteriostatic test: adopt the test tube doubling dilution to measure medicine minimum inhibitory concentration (MIC).Adopt the dull and stereotyped viable bacteria counting method of doubling dilution to measure minimal bactericidal concentration (MBC).The clean cloudy gel B of result, Chinese medicine extraction liquid A, gram positive bacteria and negative bacterium all there are certain antibacterial action, Candida albicans is also had stronger antibacterial action.MIC and MBC are respectively 0.062g/ml, 0.125g/ml..
Antifungal test in the body: at rabbit pudendum intradermal injection 0.1ml Candida albicans ATCC10231 standard bacterium bacterium liquid, the local pus infections that after 48 hours, forms.Clean cloudy gel B (100%, 50%) dosage group, Chinese medicine extraction liquid A (50%) dosage group coating every day 3 times (0.5ml/ time), matched group is coated with the equivalent normal saline.Each point was got secretions and was cultivated to observe and whether grow bacterium and determine curative effect of medication every day.The result shows that after washing liquid was cleaned treatment, onset in the 3rd day had 50% to turn out cloudy on the 5th day, recovery from illness in the 9th day.
Antipruritic test: 50 Cavia porcelluss, divide 5 groups at random, abrade right back instep depilation place, local application's (0.1ml/ foot) is after 10 minutes, (matched group is coated with the equivalent lyase) only drips 0.01% 0.05ml/ of histamine phosphate in wound face, after this every 3 minutes progressive concentrations, with occur Cavia porcellus later lick right back when sufficient give with histamine phosphate's total amount be itch-threshold, the results are shown in Table 3.Clean cloudy gel (100,50%) has highly significant to improve (P＜0.01) to the Cavia porcellus itch-threshold.25% dosage group also be significantly increased (P＜0.05).
The clean cloudy gel B of table 3 causes the influence of the reaction of itching to histamine phosphate
| Group dosage (%) itch-threshold (the total amount ug of histamine phosphate) |
| The clean cloudy gel B3 25 90.5 ± 42.84* Chinese medicine extraction liquid A 50 125.0 ± 48.31** JIEERYIN 50 162.0 ± 43.28** matched group-53.5 ± 28.29 of the clean cloudy gel B2 50 163.0 ± 48.31** of clean cloudy gel B1 100 192.0 ± 54.83** |
The skin irritation test of clean cloudy gel B and Chinese medicine extraction liquid A:
Chinese medicine: the Chinese medicine extraction liquid A of Chinese medicines such as Fructus Cnidii, Radix Sophorae Flavescentis, Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, VC.Aureomariginatn, Radix Et Rhizoma Rhei through extracting processing and preparing and forming is as the Chinese medicine pudendal lotion of gynecological external use, with and corresponding clean cloudy gel B preparation, be mainly used in the eczema of women's pudendum and send the disease of itching, also can be at ordinary times or menstruation care, consider safety for mucosa, we have carried out irritation test to it, now are reported as follows:
Test material
Animal: rabbit 1.8～2.2kg, ♂ ♀ dual-purpose.
The source: the animal testing center, Jiangxi provides.
Medicine: the diluent of clean cloudy gel B and Chinese medicine extraction liquid A, lot number: 20060217; The every ml of diluent that guarantees clean cloudy gel B contains the 0.6g crude drug or every ml contains the 1.8g crude drug; The every ml of diluent of Chinese medicine extraction liquid A contains the 0.6g crude drug or every ml contains the 1.8g crude drug.
Test method
(1) skin irritation test
Getting per 12 of healthy rabbits is one group, many group experiments are set, preceding 24 hours of intact skin administration is with 10% of the about surface area of tame rabbit back two side skin unhairing, the clean cloudy gel B of 15ml or the diluent gradation of Chinese medicine extraction liquid A are applied on the skin of rabbit, opposite side is coated with 50% ethanol and compares, and removes residual medicinal liquid after 6 hours, 1 hour, 24 hours, checked the irritant reaction of medicine in 48 hours to rabbit skin.
Clean cloudy gel B and Chinese medicine extraction liquid A are to the skin irritation reaction result:
| Erythematous response progression | Every ml contains the diluent of clean cloudy gel B of 1.8g crude drug to producing the influence of erythema | Every ml contains the Chinese medicine extraction liquid A of 1.8g crude drug to producing the influence of erythema | Every ml contains the diluent of clean cloudy gel B of 0.6g crude drug to producing the influence of erythema | Every ml contains the Chinese medicine extraction liquid A of 0.6g crude drug to producing the influence of erythema |
| The intact skin of 0 no erythema | 12 | 8 | 12 | 12 |
| 1 slight erythema | 0 | 3 | 0 | 0 |
| 2 moderate erythema | 0 | 1 | 0 | 0 |
| 3 severe erythema | 0 | 0 | 0 | 0 |
| 4 severe erythema are to slight eschar | 0 | 0 | 0 | 0 |
| The edema order of reaction | Every ml contains the diluent of clean cloudy gel B of 1.8g crude drug to producing the influence of edema | Every ml contains the Chinese medicine extraction liquid A of 1.8g crude drug to producing the influence of edema | Every ml contains the diluent of clean cloudy gel B of 0.6g crude drug to producing the influence of edema | Every ml contains the Chinese medicine extraction liquid A of 0.6g crude drug to producing the influence of edema |
| 0 anhydrous bullate intact skin | 12 | 7 | 12 | 12 |
| 1 Mild edema (reluctantly as seen) | 0 | 5 | 0 | 0 |
| 2 slight edema are (grand | 0 | 0 | 0 | 0 |
| It is clear to play profile) |
| The edema order of reaction | Every ml contains the diluent of clean cloudy gel B of 1.8g crude drug to producing the influence of edema | Every ml contains the Chinese medicine extraction liquid A of 1.8g crude drug to producing the influence of edema | Every ml contains the diluent of clean cloudy gel B of 0.6g crude drug to producing the influence of edema | Every ml contains the Chinese medicine extraction liquid A of 0.6g crude drug to producing the influence of edema |
| 3 intermediate edema | 0 | 0 | 0 | 0 |
| 4 severe edemas | 0 | 0 | 0 | 0 |
The result: the experimental group animal skin is not seen erythema, eschar or edema.The clean cloudy gel B of low concentration group and Chinese medicine extraction liquid A are qualified to the skin irritation reaction.The clean cloudy gel B of high concentration group is qualified to the skin irritation reaction.The Chinese medicine extraction liquid A of high concentration group is defective to skin irritation reaction, and it is easy to use to adopt clean cloudy gel not only to help, and the medicine that reduces high concentration is had contribution to the stimulation of skin.
Claims (1)
1. clean the moon of using of gynecological coagulates unguentum, it is characterized in that:
Be the medicament of making by following raw material: composition of raw materials: VC.Aureomariginatn 90g, Cortex Phellodendri 60g, Fructus Cnidii 90g, Radix Sophorae Flavescentis 60g, Rhizoma Coptidis 60g, Radix Scutellariae 60g, Radix Et Rhizoma Rhei 60g; Hibitane 1.0g, sodium benzoate 1.5g, Oleum menthae 1.5ml, Mentholum 0.5g; The carbomer of Tween-80 8.0ml, 20g; 300g solvent, solvent are propylene glycol or glycerol;
Preparation technology:
The preparation of VC.Aureomariginatn extractum: depletion limit winter daphne, dry to moisture for 50 ℃ and be lower than 5%, pulverize 10 mesh sieves and obtained middle coarse powder; Add the alcohol reflux 3 times of volumetric concentration 65% in the ratio of 3 times of weight of golden-rimmed winter daphne, filter, filtrate merges, and reclaims ethanol, relative density is 1.15 VC.Aureomariginatn extractum when being evaporated to 55 ℃, places room temperature, and is standby;
Get Cortex Phellodendri, Fructus Cnidii, Radix Sophorae Flavescentis, Rhizoma Coptidis, Radix Scutellariae, Radix Et Rhizoma Rhei, the decocting that adds 6 times of weight multiples respectively boils three times, 1.5 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction filtered, relative density was 1.15 clear paste when filtration was concentrated into 70 ℃, add VC.Aureomariginatn extractum, add ethanol and make and contain the alcohol amount and reach 65%, left standstill 24 hours, filter, filtrate recycling ethanol is not to there being the alcohol flavor, and addition polymerization Pyrusussuriensis ester-808.0ml adds after the water 200g stirring and dissolving again, add hibitane again, sodium benzoate, Mentholum, it is stand-by that Oleum menthae, restock water to the total amount of all substances are that 400g obtains Chinese medicine extraction liquid;
Get the carbomer of 20g, add 300g propylene glycol or glycerol swelling after, slowly splash into Chinese medicine extraction liquid, supplementing water to the total amount of all substances is that 1000g obtains clean the moon and coagulates cream.
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| CN102940831A (en) * | 2012-11-23 | 2013-02-27 | 张彦美 | External use effervescent tablet for inhibiting bacteria and curing gynecologic inflammations |
| CN108815274A (en) * | 2018-07-25 | 2018-11-16 | 博凯健康产业有限公司 | Clean maintenance bacteriostatic gel of woman and its preparation method and application |
| CN112316050A (en) * | 2020-11-09 | 2021-02-05 | 杭州宏果科技有限公司 | Antibacterial nursing lotion and application thereof |
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| CN1108571A (en) * | 1994-12-31 | 1995-09-20 | 姜璞 | "Youshengling" for giving a good birth |
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| CN1108571A (en) * | 1994-12-31 | 1995-09-20 | 姜璞 | "Youshengling" for giving a good birth |
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