CN101049375A - Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds - Google Patents
Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds Download PDFInfo
- Publication number
- CN101049375A CN101049375A CNA2007100223349A CN200710022334A CN101049375A CN 101049375 A CN101049375 A CN 101049375A CN A2007100223349 A CNA2007100223349 A CN A2007100223349A CN 200710022334 A CN200710022334 A CN 200710022334A CN 101049375 A CN101049375 A CN 101049375A
- Authority
- CN
- China
- Prior art keywords
- group
- herba
- radix
- test
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims description 21
- 230000004907 flux Effects 0.000 title 1
- 208000001848 dysentery Diseases 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 3
- 238000002360 preparation method Methods 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 239000012141 concentrate Substances 0.000 claims description 6
- 244000144977 poultry Species 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000003809 water extraction Methods 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 4
- 241000271566 Aves Species 0.000 claims description 3
- 239000003674 animal food additive Substances 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 239000008738 huangbai Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 235000008282 Sanguisorba officinalis Nutrition 0.000 abstract description 5
- 239000002131 composite material Substances 0.000 abstract description 3
- 241000272496 Galliformes Species 0.000 abstract 1
- 241000735234 Ligustrum Species 0.000 abstract 1
- 244000173853 Sanguisorba officinalis Species 0.000 abstract 1
- 241000207929 Scutellaria Species 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 44
- 230000003115 biocidal effect Effects 0.000 description 25
- 229940079593 drug Drugs 0.000 description 19
- 230000000694 effects Effects 0.000 description 17
- 206010012735 Diarrhoea Diseases 0.000 description 14
- 241000287828 Gallus gallus Species 0.000 description 14
- 230000002354 daily effect Effects 0.000 description 14
- 238000000605 extraction Methods 0.000 description 13
- 239000007788 liquid Substances 0.000 description 11
- 241000282898 Sus scrofa Species 0.000 description 9
- 235000014590 basal diet Nutrition 0.000 description 7
- 235000013330 chicken meat Nutrition 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 230000037396 body weight Effects 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 241001060350 Acalypha Species 0.000 description 5
- 206010059866 Drug resistance Diseases 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 230000035558 fertility Effects 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 description 5
- 235000013594 poultry meat Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 241000581682 Sanguisorba Species 0.000 description 4
- 241001530126 Scrophularia Species 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 238000009360 aquaculture Methods 0.000 description 4
- 244000144974 aquaculture Species 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 229940126678 chinese medicines Drugs 0.000 description 4
- 239000003640 drug residue Substances 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 201000009032 substance abuse Diseases 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- TURHTASYUMWZCC-UHFFFAOYSA-N Olaquindox [BAN:INN] Chemical compound C1=CC=C2N([O-])C(C)=C(C(=O)NCCO)[N+](=O)C2=C1 TURHTASYUMWZCC-UHFFFAOYSA-N 0.000 description 3
- 241000282894 Sus scrofa domesticus Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 241000411851 herbal medicine Species 0.000 description 3
- 229950007634 kitasamycin Drugs 0.000 description 3
- XYJOGTQLTFNMQG-KJHBSLKPSA-N leucomycin V Chemical compound CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](N(C)C)[C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1 XYJOGTQLTFNMQG-KJHBSLKPSA-N 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 229950010210 olaquindox Drugs 0.000 description 3
- 239000000273 veterinary drug Substances 0.000 description 3
- 108010001478 Bacitracin Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 2
- 235000019733 Fish meal Nutrition 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 229960005364 bacitracin zinc Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000013401 experimental design Methods 0.000 description 2
- 239000004467 fishmeal Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 235000013622 meat product Nutrition 0.000 description 2
- 230000004899 motility Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- UCRLQOPRDMGYOA-DFTDUNEMSA-L zinc;(4r)-4-[[(2s)-2-[[(4r)-2-[(1s,2s)-1-amino-2-methylbutyl]-4,5-dihydro-1,3-thiazole-4-carbonyl]amino]-4-methylpentanoyl]amino]-5-[[(2s,3s)-1-[[(3s,6r,9s,12r,15s,18r,21s)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-12-benzyl-15-[(2s)-butan-2-yl]-6-(carbox Chemical compound [Zn+2].C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@H](CC([O-])=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 UCRLQOPRDMGYOA-DFTDUNEMSA-L 0.000 description 2
- ACTOXUHEUCPTEW-BWHGAVFKSA-N 2-[(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2s,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9,16-dimethyl-2-o Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)[C@@H]1CC[C@H](N(C)C)[C@@H](C)O1 ACTOXUHEUCPTEW-BWHGAVFKSA-N 0.000 description 1
- NBOODGNJLRRJNA-IAGPQMRQSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl Chemical compound OP(O)(O)=O.O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 NBOODGNJLRRJNA-IAGPQMRQSA-N 0.000 description 1
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 235000019743 Choline chloride Nutrition 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- MVTQIFVKRXBCHS-SMMNFGSLSA-N N-[(3S,6S,12R,15S,16R,19S,22S)-3-benzyl-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentazatricyclo[20.4.0.06,10]hexacosan-15-yl]-3-hydroxypyridine-2-carboxamide (10R,11R,12E,17E,19E,21S)-21-hydroxy-11,19-dimethyl-10-propan-2-yl-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.03,7]octacosa-1(27),6,12,17,19,25(28)-hexaene-2,8,14,23-tetrone Chemical compound CC(C)[C@H]1OC(=O)C2=CCCN2C(=O)c2coc(CC(=O)C[C@H](O)\C=C(/C)\C=C\CNC(=O)\C=C\[C@H]1C)n2.CC[C@H]1NC(=O)[C@@H](NC(=O)c2ncccc2O)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H]2CC(=O)CCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C1=O)c1ccccc1 MVTQIFVKRXBCHS-SMMNFGSLSA-N 0.000 description 1
- AKDACMOZFWUOMR-JEDNCBNOSA-N N[C@@H](CCCCN)C(=O)O.[P] Chemical compound N[C@@H](CCCCN)C(=O)O.[P] AKDACMOZFWUOMR-JEDNCBNOSA-N 0.000 description 1
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004187 Spiramycin Substances 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 239000004188 Virginiamycin Substances 0.000 description 1
- 108010080702 Virginiamycin Proteins 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229960003071 bacitracin Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 229960003178 choline chloride Drugs 0.000 description 1
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000003306 quinoline derived antiinfective agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000019372 spiramycin Nutrition 0.000 description 1
- 229960001294 spiramycin Drugs 0.000 description 1
- 229930191512 spiramycin Natural products 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000021195 test diet Nutrition 0.000 description 1
- -1 triterpenoid compound Chemical class 0.000 description 1
- 229940031989 tylosin phosphate Drugs 0.000 description 1
- 229960003842 virginiamycin Drugs 0.000 description 1
- 235000019373 virginiamycin Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000016804 zinc Nutrition 0.000 description 1
Images
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
Landscapes
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
Abstract
A composite Chinese veterinary medicine for preventing and treating the dysentery of piglet and the colibacillosis of fowls is prepared from 8 Chinese-medicinal materials including scutellaria root, cherokee rose-hip, sanguisorba root, lucid ligustrum fruit, etc through extracting in water, decocting twice, adsorbing and drying.
Description
Technical field
The present invention relates to natural medicine field for animals, be specifically related to a kind of natural drug compound, it can be used as feed additive and promotes piglet growth, and yellow and white dysentery of piglet and avian colibacillosis are had the better prevention effect.
Background technology
China delivered 5.86 hundred million of barren sows in 2003 for sale, accounted for the world and delivered 47.1% of pig for sale, and 4,607 ten thousand tons of Carnis Sus domestica output account for 46.79% of world's Carnis Sus domestica output, and Carnis Sus domestica 35.38kg exceeds more than 1 times of world's per capita share (15.82kg) per capita.2004, China's livestock on hand pig number reached 4.82 hundred million.National poultry livestock on hand was 53.5 hundred million in 2005, delivered 96.7 hundred million for sale, all occupied first place in the world, and increased by 15.5% and 19.4% respectively than 2000.
But along with developing rapidly of aquaculture, breed scientific management, diseases prevention and treatment do not catch up with the development of aquaculture, have brought serious strike to aquaculture.Disease popularity is frequent day by day, and often chronic illness does not eliminate, and new disease increases again, and is hard to guard against, brought serious strike to aquaculture.If be used for the treatment of the drug main antibiotic of fowl poultry intestinal tract disease at present, as gentamycin etc.
China abuses one of more serious country of antibiotics in the world, and the human medicine still is that animal-use drug all exists the abuse problem.The bacterial drug resistance problem that causes thus is very outstanding.The clinical more isolating antibacterials of China have been soared to first place, the world to the drug resistance total quantity (for example intestinal is for the drug resistance of quinolone antibiotic) of some drugs.For a long time, the Western medicine veterinary drug is propagated its belief on a large scale in plant with its curative effect height, instant effect, and is in fashion for a time.Yet the drug resistance that the thing followed is serious day by day, curative effect reduction, drug residue and pollution problem but make and culture rather headache of boundary.The ban that the various limit drug of authoritative institution is residual, and the enhancing of ordinary consumer environmental consciousness and health perception, making has the meat product market of drug residue obviously to be obstructed, and the economic interests of plant are on the hazard.As far back as 1998, European Commission EC just issued at the ban in European Union's scope of 4 kinds of antibiotic growth promoter-bacitracin zincs, spiramycin, Virginia mycin and tylosin phosphate.Afterwards, European Union has issued ban to more antibiotic in succession.Several years ago, U.S. food and drug administration (FDA) warning U.S. feed manufacturer stops using unauthorized antibiotic in fish meal.Ban use of antibiotic scope to enlarge in the U.S. feed at present, relate to main edible animal pig, poultry and cattle.To careful use veterinary drug problem, China has also issued a series of regulations, but in actual production illegal use and the abuse of antibiotics problem very serious, people and animals' medicine is used with also very general.
The abuse of antibiotic and chemical drugs causes environmental pollution, and drug residue has influence on the food-safety problem of consumer, serious all human beings'health that jeopardize.Economic interests are ordered about, some phenomenons coastal and the super scope overdose Drug abuse additive of animal husbandry developed regions existence, and the residual human body food poisoning that causes of forbidden drug happens occasionally, and remains incessant after repeated prohibition.The focus that the topic that Drug abuse additive high residue causes the human body drug resistance to shift has become industry scientific and technical personnel to pay close attention to and study also causes the extensive concern of society and people's huge fear, and the prices fluctuate much to make livestock products.On the consumption market, carnivorous drug residue has seriously suppressed the steady growth of carnivorous consumption to a certain extent at home.In recent years, China's livestock products outlet seriously is obstructed, and European Union, the U.S., Japan, Korea S flash the redlight to China's outlet meat product again and again, and residual the exceeding standard of the carnivorous Chinese medicine that the veterinary drug improper use causes is one of the main reasons.A lot of plants have paid heavy cost for this reason.
Summary of the invention
The invention discloses a kind of natural drug composition, it can be used for preventing and treating fowl poultry intestinal tract disease, can also promote the growth of fowl poultry simultaneously.
Natural drug composition of the present invention is made up of eight flavor Chinese medicines: Radix Scutellariae, Herba Acalyphae, Fructus Rosae Laevigatae, Herba Euphorbiae Humifusae, Herba Erodii, Radix Sanguisorbae, Radix Scrophulariae and Fructus Ligustri Lucidi.The preferred ratio of weight and number of eight flavor Chinese medicines is: Radix Scutellariae 2-6 part, Herba Acalyphae 1-5 part, Fructus Rosae Laevigatae 1-5 part, Herba Euphorbiae Humifusae 1-5 part, Herba Erodii 1-5 part, Radix Sanguisorbae 1-5 part, Radix Scrophulariae 1-5 part and Fructus Ligustri Lucidi 1-5 part.
Above-mentioned natural drug composition can be directly used in feedstuff and always feed, and preferred manufacturing procedure is: with medicinal hot water extraction, concentrated getting final product in eight flavors.Also can be promptly with the compositions after concentrating and carrier such as white carbon black mixing after drying.In order to prevent that eight flavor Chinese medicines between the extract chemical reaction can take place when all mixing decocting in water, cause the product active constituent content to reduce, therefore the present invention preferably is divided into two components with eight flavor Chinese medicines and gets indescribably, one group is Radix Scutellariae, Herba Acalyphae, Fructus Rosae Laevigatae and Herba Euphorbiae Humifusae, another group is Herba Erodii, Radix Sanguisorbae, Radix Scrophulariae and Fructus Ligustri Lucidi, uses hot water extraction respectively for two groups, concentrates the back remix, so separately extraction can obtain the highest effective ingredient of concentration, the performance maximum effect.Before extracting, preferably soak, its objective is to make medical material organize moistening infiltration, in order to the dissolving and the leaching of effective ingredient.Decocting time was selected greater than 0.5 hour, generally about 1~3 hour, in order to improve the extract productive rate, can select secondary to decoct, and secondary decocts more can fully extract middle pharmaceutically active ingredient.
Natural drug composition of the present invention is efficient, the stable prophyiaxis and promoting growth additive that extracts from natural Chinese medicinal herb, contains active ingredients such as multiple alkaloid, triterpenoid compound, glycoside, flavone, has antibiotic, antiviral, enhancing human body immunity function.Show good diseases prevention and growth promotion effect in the test of piglet, this effect has also obtained checking in the test of broiler and laying hen.Be part test and result below:
One, natural drug composition of the present invention is to the influence of suckling piglet fertility performance
1 materials and methods
1.1 natural drug composition of the present invention (hereinafter to be referred as the joy treasured), enteric Kitasamycin 500 granular preparations, kangdisu sulfas 100, olaquindox, 4% premix material composition see Table 2; Piglet is Du * length * Dasanyuan hybridized pig.
1.2 experimental animal and EXPERIMENTAL DESIGN: selecting with 9 of the sows of kind, according to close principle of parity, expected date of confinement, is a repetition with every nest piglet, and every group of 3 repetitions are divided into A, B, three groups of C.With the A group is matched group, adds Kitasamycin, kangdisu sulfas and olaquindox; B, C group is added 350ppm, 500ppm (concentration of medicine in feedstuff) joy treasured (seeing Table 1) respectively for test group, and test pig adopts identical daily ration to handle.
Table 1 test is handled
Test number | A | B | C |
Test is handled | Kitasamycin 40ppm+ kangdisu sulfas 50ppm+ olaquindox 50ppm | The precious 350ppm of joy | The precious 500ppm of joy |
Test sow number | 3 | 3 | 3 |
Test piglet number | 28 | 26 | 26 |
The feed joy treasured of basal diet+various dose of basal diet+antibiotic 1.3 test diet: A group is fed, B, C.The experimental basis daily ration is formed and nutrition sees Table 2
Table 2 experimental basis daily ration
Raw material is formed | Corn | Bean cake | Imported fish meal | Whey powder | Premix material |
61 | 26 | 4 | 5 | 4 | |
Nutrition | Digestible energy | Thick protein | Calcium | Total phosphorus | Lysine |
13.51MJ/kg | 20% | 0.81% | 0.72% | 1.20% |
1.4 feeding and management:
1.4.1 artificial the throwing raised powder, free choice feeding is freely drunk water; The wean of piglet 25 ages in days; To 38 age in days off-tests;
1.4.2 the personal management, each group is carried out under identical feeding and management and environmental condition;
1.4.3 observe and record: every day the viewing test pig search for food, diarrhoea and active situation, and carry out record.When on-test, wean and end, respectively test pig is carried out full group and weigh.
2 test results and analysis
2.1 test pig body weight and equal daily gain situation see Table 3
Table 3 each test group body weight and weightening finish
Group | The A group | The B group | The C group |
7 age in days counterpoises (kg/ head) | 2.80 | 2.73 | 2.89 |
25 age in days weanling weights (kg/ head) | 7.35 | 7.28 | 7.11 |
38 age in days body weight (kg/ head) | 11.83 | 12.17 | 12.23 |
7~25 ages in days weightening finishes (kg/ head) | 4.55 | 4.55 | 4.22 |
25~38 ages in days weightening finishes (kg/ head) | 4.48 | 4.89 | 5.12 |
At 7~25 ages in days, three groups of average daily gains are 253g, 253g, 234g, and C group may be relevant with the milk water quality of sow a little less than A, B group because this in stage piglet based on sucking; 25~38 ages in days, three groups of average daily gains are respectively 320g, 349g, 366g, and the precious group of joy daily gain is better than the antibiotic group, improves 9.06% and 14.38% than antibiotic group respectively; As if gaining effect is proportional with the precious additive capacity of joy, shows that the joy treasured has special advantages aspect the prevention suckling piglet ablactation stress.
2.2 influence to pig starter feed efficient
By the equal feed consumption of visible 7~25 age in days piglet heads of table 4 is 292.31g~321.15g, and material anharmonic ratio 0.065~0.071: 1 does not have significant difference between each group, and piglet is main relevant with the sucking stage therewith.25~38 ages in days, C group feed consumption rate are apparently higher than A, B group, and the B group is a little more than the A group, and the precious group material of joy anharmonic ratio obviously is better than antibiotic group (A group), reduces by 7.43%, 8.78% than antibiotic group (A group) respectively; Above results suggest joy treasured has appetite stimulator, improves feed intake, improves the effect of piglet fertility performance.
Table 4 is respectively organized food consumption and conversion ratio unit: the g/ head
Group | The A group | The B group | The C group |
7~25 age in days feed consumption rates | 296.43 | 321.15 | 292.31 |
7~25 age in days material anharmonic ratioes | 0.065∶1 | 0.071∶1 | 0.069∶1 |
25 ages in days~38 age in days feed consumption rates | 6630.47 | 6699.32 | 6912.24 |
25 ages in days~38 age in days material anharmonic ratioes | 1.48∶1 | 1.37∶1 | 1.35∶1 |
2.3 duration of test piglets diarrhoea situation sees Table 5
Table 5 a piglets diarrhoea number of days and diarrhea rate
Group | A | B | C |
The piglet number | 28 | 26 | 26 |
7~25 an ages in days diarrhoea number | 14 | 15 | 5 |
∑ 7~25 ages in days are raised a number of days | 504 | 468 | 468 |
7~25 age in days diarrhea rates | 2.78% | 3.21% | 1.07% |
25~38 an ages in days diarrhoea number of days | 4 | 3 | 1 |
∑ 25~38 ages in days are raised a number of days | 392 | 364 | 364 |
25~38 age in days diarrhea rates (%) | 1.02% | 0.82% | 0.27% |
∑ is tested a full phase diarrhoea number of days | 18 | 18 | 6 |
∑ is tested the full phase and is raised a number of days | 896 | 832 | 832 |
Full phase diarrhea rate (%) | 2.01% | 2.16% | 0.72% |
This test data shows that the joy treasured can replace antibiotic aspect the prevention suckling piglet diarrhoea fully, and each group wean back diarrhea rate is all lower, and in 25~38 age in days weaning periods, the effect of the precious control of joy piglet diarrhea is better than antibiotic especially.
3 results and discussion
Chinese herbal medicine is run concurrently and is supported and medicinal double attribute, except certain nutrient value, mainly contains antibacterial activity or other biological activity, and Chinese herbal feed additive research has obtained application result preferably in China.The joy treasured is multiple Chinese herbal medicine extract, this test shows, add Chinese herbal medicine extract-joy treasured in the piglet diet and can prevent suckling piglet diarrhoea preferably, promote the suckling piglet growth, improve feed efficiency, during weaned piglet, its weightening finish is better than antibiotic with anti-diarrhoea effect, is first-selected at present antibiotic succedaneum especially.
Two, natural drug composition of the present invention is to the fertility performance influence of laying hen
1 test material and method
1.1 experimental animal and EXPERIMENTAL DESIGN:
Select 800 plumage body weight close 49 the week age Luo Man laying hen, be divided into 4 groups at random, establish 4 repetitions for every group, each repeats 50 plumages.Testing the full phase amounts to 6 weeks (comprising 7 days phases of raising in advance).Test grouping situation sees Table 6 wherein, and matched group is blank group, and test I, II, III group are the precious gradient group of joy.
Table 6 test grouping situation
Group | Matched group | Test I group | Test II group | Test III group |
Handle | Blank | The precious 100ppm of joy | The precious 150ppm of joy | The precious 200ppm of joy |
Repeat number * chicken number | 4×50 | 4×50 | 4×50 | 4×50 |
1.2 feeding and management:
Just the examination phase begins fertility performance and health status zero difference between preceding group.Powder free choice feeding, artificial feeding, nipple-shape automatic drinking bowl drinking-water.Semi open model is hen house fixedly, and three layers of full ladder of biserial are raised in cages, 4 chickens of every cage.Every day, egg was chosen in 2 craft.Feeding and management maintenance and jumpbogroup are produced in full accord.
1.3 test daily ration prescription:
The experimental basis daily ration: the material type is a powdery, and its feed formula sees Table 7
Table 7 daily ration prescription is formed
Daily ration is formed | Proportioning | Daily ration is formed | Proportioning | |
Corn | 628.7kg | Stone powder | 86kg | |
Bean cake | 188kg | Sal | 3.0kg | |
Rapeseed cake | 38kg | Methionine | 1.2kg | |
Testa Tritici | | Choline chloride | 50% | 1.0kg |
Peru's angle powder | 13kg | Grandidierite adds | 2.0kg | |
Calcium hydrogen phosphate | 14.8kg | The laying hen multidimensional | 0.3kg | |
Amount to | 1000.0kg |
1.4 observation index and date processing:
Write down amount of livestock on hand every day, the sum of laying eggs, total egg size, food consumption and the dead number of washing in a pan.Calculate laying rate, egg size, the price of deed, death rate.Data are carried out single factor analysis.
2. interpretation of result and discussion
Laying rate is of paramount importance index during laying hen produces all the time.The result shows the joy treasured that adds various dose, all can improve the laying rate (see figure 1) in various degree, the test group laying rate is higher than matched group all the time in the experimental period in 5 weeks, the precious effect of 150ppm and 200ppm joy is better than 100ppm, and it is close with the 200ppm effect to add 150ppm.
Result of the test shows that the joy treasured improves the price of deed to improving laying rate of laying hen, and all there is good effect aspects such as reduction death rate.
Three, natural drug composition of the present invention is to the influence of meat chicken production performance
1 materials and methods
1.1 test chicken group: select young 600 of healthy active, normotrophic AA meat, be divided into three groups at random, establish four repetitions for every group, 50 of every repetitions.If test I group (the precious group of joy), test II group (antibiotic group: colistine sulfate and bacitracin zinc), matched group.
1.2 test daily ration: the experimental basis daily ration is preparation voluntarily, adds " joy treasured " 200ppm in the test I group basal diet, adds colistine sulfate 20ppm, bacitracin zinc 50ppm, the control group fed basal diet in the test II group basal diet.Basal diet and trophic level see Table 8.
Table 8 basal diet
Proportioning (%) | Trophic level | ||
Corn | 60 | Metabolizable energy (MJ/KG) | 12.13 |
Bean cake | 35 | Thick protein (%) | 21 |
Premix material | 5 | Calcium (%) | 0.9 |
Add up to | 100 | Available phosphorus (%) | 0.45 |
1.3 feeding and management: raise on test broiler plane, the secondary that feeds intake every day, and free choice feeding is freely drunk water, and the immunity epidemic prevention is undertaken by normal procedure, and each group is raised term harmonization.Write down feed consumption rate, the death toll of test chicken every day, be that unit carries out empty stomach and weighs morning with the repeating groups in on-test, when finishing.
1.4 date processing and analysis
Data are carried out the SPSS11.5 statistical analysis after Excel 2000 handles, data are average ± standard error (x ± SE).
2 test results and analysis
2.1 the joy treasured is to the influence of meat chicken production performance
Duration of test, each organizes the chicken physical health, the no abnormal situation of appetite.Broiler zero difference between the body weight group when 0 age in days as shown in Table 9.During off-test (21 age in days), the precious group of joy, antibiotic group, matched group body weight are respectively 668.3g, 661g, 629.9g, significant difference (P<0.05).The precious group of joy and antibiotic group weightening finish comparison according to component you can well imagine high by 6.56%, 5.28%, the precious group of joy gaining effect is better than the antibiotic group, but group difference not significantly (P>0.05).
Table 9 joy treasured is to the influence of 0~21 age in days broiler chicken fertility performance
Annotate: different letter representation significant differences (P<0.05) are arranged in the same column data.
2.2 the joy treasured is to the influence of broiler fodder conversion ratio and survival rate
Result of the test (table 10) shows that the precious group material of joy anharmonic ratio is 1.41: 1, and antibiotic group material anharmonic ratio is 1.40: 1, and matched group material anharmonic ratio is 1.49: 1, and two groups have descended 5.37%, 6.04% than matched group respectively.The joy treasured reaches the effect similar to the antibiotic group.The precious composition of joy motility rate is 97.5%, and antibiotic is formed motility rate 98%, matched group survival rate 93.5%, and joy treasured, antibiotic all can obviously improve survival rate.Find out that thus the joy treasured has good disease-resistant and prophylaxis effect, and can substitute antibiotic application in broiler is produced fully.
Table 10 joy treasured is to the influence of 0~21 age in days broiler chicken feed conversion rate and survival rate
Description of drawings
Fig. 1 is the influence of natural drug composition of the present invention to laying rate
The specific embodiment
Embodiment 1
1 part of 1 part of Herba Euphorbiae Humifusae of 1 portion of Fructus Rosae Laevigatae of 2 parts of Herba Acalyphaes of Radix Scutellariae
1 part of 1 part of Fructus Ligustri Lucidi of 1 portion of Radix Scrophulariae of 1 portion of Radix Sanguisorbae of Herba Erodii
Preparation method:
Pretreatment with Chinese medicine: carry out pretreatment to extracting used Chinese crude drug, promptly clean, clean and drain, and Chinese crude drug is divided into two groups by 1# (Radix Scutellariae, Herba Acalyphae, Fructus Rosae Laevigatae, Herba Euphorbiae Humifusae) and 2# (Herba Erodii, Radix Sanguisorbae, Radix Scrophulariae, Fructus Ligustri Lucidi).
One, extraction concentrates:
1, Chinese medicine extraction liquid 1# extracts and concentrates:
(1) checks at first whether the extraction pot valve closes (residual cake valve, bleeder valve), then with Radix Scutellariae, Herba Acalyphae, Fructus Rosae Laevigatae, Herba Euphorbiae Humifusae feeds intake, by material, water added behind the water merceration 3 hours than 1: 5, open Steam Heating, to decoct 2 hours so that 100-110 ℃ temperature is lasting again behind the water boil in the extraction pot, steam is closed vexed 4 hours (during the medicinal liquid in the extraction pot was once carried out periodicity in per 30 minutes with feed pump force outer circulation), then with extracting solution suction fluid reservoir, then again by material, water added water to carry out two and fries in shallow oil than 1: 1, decocted 1 hour, and emitted medicinal residues after waiting to extract medicinal liquid.
(2) close the concentration tank bleeder valve, open recirculated cooling water, the preceding inlet valve of pump again, open inlet valve and feed pump then, the medicinal liquid of fluid reservoir is got in the concentration tank, level control is under manhole about 10cm, close feed pump and inlet valve then, open steam, open vacuum pump, carry out concentrating under reduced pressure (observe feed liquid at set intervals,, must progressively feed in raw material) then if reduce, elder generation's steam off, vacuum pump during discharging, then open air valve to normal pressure, open the material-compound tank inlet valve again, open the material-compound tank feed pump at last and begin discharge.
2, Chinese medicine extraction liquid 2# extracts and concentrates:
Press Chinese medicine extraction liquid 2# prescription neck material, operate by the extraction concentration process of above-mentioned Chinese medicine extraction liquid 1#.
Two, composite:
Treat that Chinese medicine extraction liquid 1# and Chinese medicine extraction liquid 2# squeeze in the material-compound tank, open stirring motor and stir, and whether will open steam insulation or heating, wait to emit after stirring and contain all turning barrels according to temperature decision in season.
Three, absorption oven dry:
White carbon is added trough type mixing machine, open trough type mixing machine, with watering pot composite Chinese medicine extraction liquid is sprayed into while stirring, treat the absorption baking oven of packing into after good, oven temperature is no more than 90 ℃, and moisture content of finished products is controlled at below 5% after the baking.
Four, the packing of sieving:
Semi-finished product after the oven dry are sieved in shaking screen, then compound evenly after, the vanning warehouse-in.
Embodiment 2
5 parts of 5 parts of Herba Euphorbiae Humifusaes of 5 portions of Fructus Rosae Laevigatae of 6 parts of Herba Acalyphaes of Radix Scutellariae
5 parts of 5 parts of Fructus Ligustri Lucidi of 5 portions of Radix Scrophulariaes of 5 portions of Radix Sanguisorbaes of Herba Erodii
Preparation method is with embodiment 1.
Embodiment 3
3 parts of 3 parts of Herba Euphorbiae Humifusaes of 3 portions of Fructus Rosae Laevigatae of 4 parts of Herba Acalyphaes of Radix Scutellariae
3 parts of 3 parts of Fructus Ligustri Lucidi of 3 portions of Radix Scrophulariaes of 3 portions of Radix Sanguisorbaes of Herba Erodii
Preparation method is with embodiment 1.
Embodiment 4
2 parts of 2 parts of Herba Euphorbiae Humifusaes of 2 portions of Fructus Rosae Laevigatae of 3 parts of Herba Acalyphaes of Radix Scutellariae
2 parts of 2 parts of Fructus Ligustri Lucidi of 2 portions of Radix Scrophulariaes of 2 portions of Radix Sanguisorbaes of Herba Erodii
Preparation method is with embodiment 1.
Embodiment 5
4 parts of 4 parts of Herba Euphorbiae Humifusaes of 4 portions of Fructus Rosae Laevigatae of 5 parts of Herba Acalyphaes of Radix Scutellariae
4 parts of 4.5 parts of Fructus Ligustri Lucidi of 4 portions of Radix Scrophulariaes of 4 portions of Radix Sanguisorbaes of Herba Erodii
Preparation method is with embodiment 1.
Claims (6)
1, a kind of Chinese medicine composition of preventing and treating fowl poultry digestive tract disease is characterized in that being formed by the feedstock production of following component and weight ratio: Radix Scutellariae 2-6 part, Herba Acalyphae 1-5 part, Fructus Rosae Laevigatae 1-5 part, Herba Euphorbiae Humifusae 1-5 part, Herba Erodii 1-5 part, Radix Sanguisorbae 1-5 part, Radix Scrophulariae 1-5 part and Fructus Ligustri Lucidi 1-5 part.
2, the preparation method of the Chinese medicine composition of claim 1 comprises: will in medicinal hot water extraction, concentrate, be drying to obtain.
3, the preparation method of claim 2, wherein be one group and mix the back hot water extraction Radix Scutellariae, Herba Acalyphae, Fructus Rosae Laevigatae and Herba Euphorbiae Humifusae, Herba Erodii, Radix Sanguisorbae, Radix Scrophulariae and Fructus Ligustri Lucidi are one group mix the back hot water extraction that extracting solution concentrates respectively, dry back remix.
4, the Chinese medicine composition of claim 1 is used to prepare the purposes of the medicine for the treatment of pig HUANGBAI(sic) dysentery.
5, the Chinese medicine composition of claim 1 is used to prepare the purposes of the medicine for the treatment of avian colibacillosis.
6, the Chinese medicine composition of claim 1 is as the purposes of feed additive.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007100223349A CN100525800C (en) | 2007-05-14 | 2007-05-14 | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007100223349A CN100525800C (en) | 2007-05-14 | 2007-05-14 | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101049375A true CN101049375A (en) | 2007-10-10 |
CN100525800C CN100525800C (en) | 2009-08-12 |
Family
ID=38781111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2007100223349A Expired - Fee Related CN100525800C (en) | 2007-05-14 | 2007-05-14 | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100525800C (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102657296A (en) * | 2012-05-25 | 2012-09-12 | 江西赣达牧业有限公司 | Traditional Chinese medicine health-care type feed for suckling pigs |
CN104082529A (en) * | 2014-05-28 | 2014-10-08 | 青岛华仁技术孵化器有限公司 | Feed for controlling piglet's yellow-white dysentery |
CN104543576A (en) * | 2015-01-16 | 2015-04-29 | 湖南省五季风生物科技有限责任公司 | Compound plant-extract feed additive for preventing and treating piglet diarrhea, as well as preparation method and application thereof |
CN106267153A (en) * | 2016-08-22 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and colistin |
CN106344507A (en) * | 2016-11-17 | 2017-01-25 | 无锡奔牛生物科技有限公司 | Preparation method of radix scutellariae toxin-resolving powder oral liquid |
CN109349425A (en) * | 2018-10-27 | 2019-02-19 | 江苏波杜农牧股份有限公司 | A kind of Chinese herbal feed additive and preparation method thereof |
CN111011628A (en) * | 2019-12-19 | 2020-04-17 | 何先清 | Plant extract and preparation method and application thereof |
CN111358850A (en) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
-
2007
- 2007-05-14 CN CNB2007100223349A patent/CN100525800C/en not_active Expired - Fee Related
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102657296A (en) * | 2012-05-25 | 2012-09-12 | 江西赣达牧业有限公司 | Traditional Chinese medicine health-care type feed for suckling pigs |
CN104082529A (en) * | 2014-05-28 | 2014-10-08 | 青岛华仁技术孵化器有限公司 | Feed for controlling piglet's yellow-white dysentery |
CN104082529B (en) * | 2014-05-28 | 2016-05-11 | 张绪伟 | For preventing and treating the feed of piglet yellow-white dysentery |
CN104543576A (en) * | 2015-01-16 | 2015-04-29 | 湖南省五季风生物科技有限责任公司 | Compound plant-extract feed additive for preventing and treating piglet diarrhea, as well as preparation method and application thereof |
CN104543576B (en) * | 2015-01-16 | 2018-02-09 | 湖南沙博安五季丰生物科技有限公司 | Prevent and treat composite vegetables extractive feed addictive and its preparation method application of grice diarrhoea |
CN106267153A (en) * | 2016-08-22 | 2017-01-04 | 广西大学 | A kind of poultry compound medicine containing Fructus Rosae Laevigatae and colistin |
CN106344507A (en) * | 2016-11-17 | 2017-01-25 | 无锡奔牛生物科技有限公司 | Preparation method of radix scutellariae toxin-resolving powder oral liquid |
CN109349425A (en) * | 2018-10-27 | 2019-02-19 | 江苏波杜农牧股份有限公司 | A kind of Chinese herbal feed additive and preparation method thereof |
CN111011628A (en) * | 2019-12-19 | 2020-04-17 | 何先清 | Plant extract and preparation method and application thereof |
CN111358850A (en) * | 2020-04-26 | 2020-07-03 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
CN111358850B (en) * | 2020-04-26 | 2022-04-19 | 河南牧翔动物药业有限公司 | Traditional Chinese medicine composition for preventing and treating chicken colibacillosis and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN100525800C (en) | 2009-08-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1216541C (en) | Birds feed additive | |
CN101167918B (en) | Traditional Chinese medicinal preparation for increasing immunity of pig or poultry | |
CN101313731B (en) | Anti-stress feedstuff additive | |
CN100525800C (en) | Composition of Chinese traditional medicine for treating yellow / white flux of baby pig, and colibacillosis of birds | |
CN103392669A (en) | Method for feeding high-quality cocks by probiotics and traditional Chinese medicine and utilized feed | |
CN1346600A (en) | Process for preparing antibiotic-free pollution-free feed of domestic animals and fawls and its product | |
CN105010884A (en) | Environment-friendly pig feed efficient in growth promotion and preparation method thereof | |
CN105494910A (en) | Growing and fattening pig feed preparation method | |
CN102524589B (en) | Weaned pig feed as well as preparation method and application thereof | |
CN103404696A (en) | Environmentally-friendly compound Chinese herbal medicinal feed additive for enhancing immunities of broilers, and application thereof | |
CN102524584B (en) | Composite pig feed additive for effectively preventing edema of pigs | |
CN102078522A (en) | Chinese medicine composition for treating enterovirus syndrome in chicken | |
CN1709127A (en) | Composite fodder addiive of Chinese herbal medicine for goose fattening and its preparing process | |
CN103039725B (en) | Health-care chick starter feed | |
CN101167774B (en) | Ginseng and American ginseng different parts extraction and its application for poultry and livestock | |
CN106036075A (en) | Green and environment-friendly milk cow feed additive | |
CN1868302A (en) | Chinese herb medicine additive for chicken feed | |
CN1134238A (en) | Additive baishichuqinkang for farm animal feed and its producing method | |
CN1202737C (en) | Accelerant health protection additive of feedstuff using Chinese traditional medicine and its preparation method | |
CN1757305A (en) | Chinese herbal medicine feed additive and preparation method thereof | |
CN103892112A (en) | Efficient and health-care concentrated feed for broiler chicken | |
CN105941321B (en) | A kind of swine rearing method | |
CN103190546A (en) | Additive for improving production property of sows as well as preparation method and application thereof | |
CN108634126A (en) | A kind of antibiotic-free Chinese medicine additive of meat chicken feed and fodder compound improving immunity | |
CN103315161B (en) | Special feed additive for broiler chick |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 214112 Jiangsu province Wuxi City Meicun Industrial Park of Xintai Qunxing Road No. 51 Patentee after: WUXI ZHENGDA BIOLOGY CO., LTD. Address before: 214112 Jiangsu province Wuxi City Meicun Industrial Park of Xintai Qunxing Road No. 51 Patentee before: Wuxi Zhengda Poultry Co., Ltd. |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090812 Termination date: 20170514 |