CN101019984B - Constipation treating Chinese medicine preparation - Google Patents
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Abstract
The present invention relates to one kind of Chinese medicine preparation for treating constipation. The Chinese medicine preparation is prepared with rhubarb, fructus cannabis, aloe, cassia seed and other Chinese medicinal materials. It has the functions of relieving constipation, promoting digestion to dispel food stagnation, nourishing yin and moistening dryness. The present invention is developed through combining Chinese medicine theory and modern research result. The Chinese medicine preparation has determined curative effect, high safety, no toxic side effect and low cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of constipation, is that a kind of to treat constipation be the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Constipation system is because of deficiency of both vital energy and Yin, or dryness-heat stagnating in the interior, and due to internal organs gas was not smooth, with the infrequent defecation time lengthening, constipation with dry stool was difficult to resolve the disease into main clinical manifestation.Often refer to habitual constipation.Primary disease can betide any age patient, and young and middle-aged sickness rate is about 1%～5%, and old people's sickness rate both had been found in the process of multiple disease up to 15%～30%, can independently occur again, also is physical work minimizing or long-term bed patient's common complication.
Constipation traditional Chinese medical science title at all times is a lot, " difficulty in defecation ", " back is unfavorable ", " spleen-constipation ", " constipation caused by accumulation of heat ", " constipation of YIN type ", " intestinal knot ", " constipation due to pathogenic wind ", " functional constipation ", " wind-dryness ", " heat is dry ", " constipation due to insufficiency " etc. is arranged, existing general designation " constipation ".
Chinese medicine think constipation be a variety of causes cause the large intestine conduction function not normal due to, its reason has: 1, large intestine dryness-heat stagnating in the interior.2, depression and stagnation of QI.3, qi-blood-body fluid is lost empty.4, year is high weak.The sick position of primary disease is at large intestine, and is relevant with lung, liver,spleen,kidney.So the traditional Chinese medical science is divided into the deficiency and excess two ends in dialectical treatment, with sthenia syndrome requiring purgation, deficiency syndrome should be treated by tonifying method is the rule of treatment; Constipation of excess type is divided into: functional constipation, constipation due to disorder of QI.Constipation due to insufficiency is divided into: the deficiency of vital energy is secret, hematasthenic constipation, suffer from a deficiency of the kidney secret, the deficiency of YIN is secret.Chronic constipation is a kind of commonly encountered diseases of digestive system.Since constipation repeatedly or continue outbreak, bring very big misery to the patient, influence people's live and work, even can bring out or increase the weight of old people's cardiovascular and cerebrovascular disease and cause intestinal obstruction, threat to life safety.Though in recent years the pathogenesis of primary disease is studied, think with defecation adynamia, spastic colon, the rectum defecation reflex is blunt or forfeiture, autonomous defecation reflex weaken, encysted rectum etc. is relevant, but western medicine, takes stopgap measures and does not effect a permanent cure mainly based on the clothes cathartic the treatment primary disease.Even up-to-date short digestive tract power reinforcing medicine cisapride, the curative effect of its treatment constipation is also not fully up to expectations.
The Chinese medicine constipation not only has superiority aspect relieving constipation, and in constipation relieving, disorderly gastrointestinal function obtains adjusting, and patient's physical condition is improved.Because tcm clinical efficacy is good, toxic and side effects is little, is accepted by the patient easily.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of constipation.Have determined curative effect, safe ready, little, the cheap characteristics of toxic and side effects.
The present invention is made by the following weight proportion raw material:
2.5～10 parts of 1.5～6 portions of Folium Sennae of 2.5～10 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
1.5～6 parts of 1.5～6 parts of Semen Cassiaes of 2.5～10 portions of Aloes of Fructus Cannabis
1.5～6 parts of 1.5～6 parts of Semen Persicae (parched)s of 1.5～6 parts of Fructus Aurantii Immaturuss of Semen Pruni
0.1～2 part of 0.1～2 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
The weight proportion of each raw material of optimization formula of the present invention is:
3～7 parts of 2.5～3.5 portions of Folium Sennae of 3～7 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
2.5～3.5 parts of 2.5～3.5 parts of Semen Cassiaes of 3～7 portions of Aloes of Fructus Cannabis
2.5～3.5 parts of 2.5～3.5 parts of Semen Persicae (parched)s of 2.5～3.5 parts of Fructus Aurantii Immaturuss of Semen Pruni
0.5～1.5 part of 0.5～1.5 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
The weight proportion of each raw material of optimum formula of the present invention is:
5 parts of 3 portions of Folium Sennae of 5 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
3 parts of 3 parts of Semen Cassiaes of 5 portions of Aloes of Fructus Cannabis
3 parts of 3 parts of Semen Persicae (parched)s of 3 parts of Fructus Aurantii Immaturuss of Semen Pruni
1 part of 1 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
Drug action mechanism among the present invention is as follows:
Radix Et Rhizoma Rhei property of medicine hardship, cold.Return stomach, large intestine, liver, spleen channel.Have attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, antidotal effect.Can treat the food stagnation constipation, the accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria; Conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting; Spit blood, spitting of blood, epistaxis is had blood in stool, hematuria; Blood-retention, amenorrhea, the stagnant stomachache of the stasis of blood in puerperal ， lumps in the chest and abdomen, traumatic injury; Pyretic toxicity carbuncle and ulcer, erysipelas is scalded etc.(the 141st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Fructus Cannabis property of medicine is sweet, and is flat.Return spleen, stomach, large intestine channel.Has the laxation of moisturizing, diuretic, the effect of invigorating blood circulation.Can treat the dryness of the intestine constipation, migratory arthralgia is quenched one's thirst, edema due to wind pathogen, beriberi, pyretic stranguria, dysentery, menoxenia, skin ulcer tinea, erysipelas etc.(the 696th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Natrii Sulfas property of medicine is salty, bitter, and is cold.Return stomach, large intestine channel.Has the pathogenic fire purging relieving constipation, softening the hard mass, repercussive effect.It is stagnant to treat excess-heat, constipation, abdominal distention painful abdominal mass pain, acute appendicitis, acute mastitis, erysipelas, conjunctival congestion cataracta, laryngopharynx swelling and pain, aphtha etc.(the 1156th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Folium Sennae property of medicine is sweet, bitter, cold.Return large intestine channel.Has purging heat to relax the bowels, the effect of consumer product dredge stasis.Can treat constipation with heat retention, habitual constipation, stagnant abdominal distention, edema tympanites, stomach, duodenal ulcer and hemorrhage etc.(the 3369th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Aloe property of medicine hardship, cold.Return liver, large intestine channel.Have and rush down down liver heat removing, parasiticidal effect.Can treat constipation with heat retention, liver-fire headache, conjunctival congestion infantile convulsion, abdominal pain due to worm stagnation, scabies, hemorrhoid complicated by anal fistula etc.(the 1499th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Semen Cassiae property of medicine hardship, sweet, salty is slightly cold.Return liver, kidney, large intestine channel.Has liver heat removing and eyesight improving, the effect of diuretic relieving constipation.Can treat conjunctival congestion and swelling pain, photophobia tear is many, optic atrohic blindness, nyctalopia, headache and dizzy, poor vision, tympanites, habitual constipation, toxic swelling, tinea disease etc.(the 1310th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Semen Pruni property of medicine suffering, hardship, sweet, flat.Return spleen, large intestine, small intestine meridian.Has loosening bowel to relieve constipation, the effect of therapeutic method to keep the adverse QI flowing downwards diuretic.Can treat the dryness of the intestine constipation, dysuria, edema abdominal distention, beriberi etc.(the 1858th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Semen Persicae (parched) property of medicine hardship, sweet, mild toxicity.GUIXIN, liver, large intestine channel.Has blood circulation promoting and blood stasis dispelling, the effect of loosening bowel to relieve constipation.Can treat dysmenorrhea, amenorrhea due to stagnation of blood, the stagnant stomachache of the stasis of blood in puerperal ， mass in the abdomen caking, traumatic injury, swelling and pain due to blood stasis, lung abscess, acute appendicitis, dryness of the intestine constipation etc.(the 2542nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Fructus Aurantii Immaturus property of medicine hardship, suffering are slightly cold.Return spleen, stomach, large intestine channel.Have the dispelling the stagnated QI removing food stagnancy, reduce phlegm except that the effect of painful abdominal mass.Can treat and stop in stagnant, the feeling of fullness distending pain, constipation, heavy behind the dysentery, blocked-up chest, the thoracic obstruction, gastroptosis, uterine prolapse, proctoptosis etc.(the 2230th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Fructus Crataegi property of medicine acid, sweet, tepor.Return spleen, stomach, Liver Channel.Has promoting digestion and invigorating the stomach, the effect of circulation of qi promoting dissipating blood stasis.Can treat eating accumulation, abdominal distention, diarrhea dysentery, amenorrhea, puerperal abdonimal pain, lochiorrhea, hernia or painful and swollen testis, hyperlipidemia etc.(the 226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Endothelium Corneum Gigeriae Galli (parched) nature and flavor are sweet, and are flat.Return spleen, stomach, small intestinal, urinary bladder channel.Has invigorating the stomach and promoting digestion, the effect of arresting seminal emission.Can treat food stagnation and not disappear, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission etc.(the 151st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch with Radix Et Rhizoma Rhei, Fructus Cannabis, Natrii Sulfas and Folium Sennae; Aloe, Semen Cassiae, Semen Pruni, Semen Persicae (parched) and Fructus Aurantii Immaturus are minister; Fructus Crataegi and Endothelium Corneum Gigeriae Galli (parched) make for assistant.All medicines are harmonious, and are total to the tool purging heat to relax the bowels, consumer product dredge stasis, nourishing yin and moistening dryness.The treatment constipation has determined curative effect, and toxic and side effects is little, taking convenience, cheap characteristics.
Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.
Preparation of the present invention, preferably peroral dosage form is as tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment constipation of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention treats constipation and has determined curative effect, and toxic and side effects is little, taking convenience, cheap characteristics.
Further specify the therapeutic effect of medicine of the present invention below by the clinical practice example to the treatment constipation.
Constipation efficacy assessment standard: 1, cure: just matter was changeed profit with interior defecation 1 time in 2 days, and unobstructed when separating, short-term does not have recurrence.2, take a turn for the better: just matter was changeed profit with interior defecation in 3 days, and it is smooth that defecation is owed.3, do not heal: symptom does not have improvement.(the 109th page of chief editor's " traditional Chinese medical science disease diagnosis and treatment standard and prescription are selected for use " People's Health Publisher's calendar year 2001 version such as Dai Shen)
For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment constipation; Treatment constipation patient 40 examples.Take embodiment 3 granules, each 1～3 bag, three to four times on the one, boiled water is taken after mixing it with water, and take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.Cure 36 examples and account for 90%, 4 examples that take a turn for the better account for 10%, and total effective rate reaches 100%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
Embodiment 1 capsule takes by weighing raw material by following weight:
5 parts of 3 portions of Folium Sennae of 5 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
3 parts of 3 parts of Semen Cassiaes of 5 portions of Aloes of Fructus Cannabis
3 parts of 3 parts of Semen Persicae (parched)s of 3 parts of Fructus Aurantii Immaturuss of Semen Pruni
1 part of 1 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 2 tablets take by weighing raw material by following weight:
5 parts of 3 portions of Folium Sennae of 5 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
3 parts of 3 parts of Semen Cassiaes of 5 portions of Aloes of Fructus Cannabis
3 parts of 3 parts of Semen Persicae (parched)s of 3 parts of Fructus Aurantii Immaturuss of Semen Pruni
1 part of 1 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, one month is a course of treatment.
Embodiment 3 granules take by weighing raw material by following weight:
5 parts of 3 portions of Folium Sennae of 5 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
3 parts of 3 parts of Semen Cassiaes of 5 portions of Aloes of Fructus Cannabis
3 parts of 3 parts of Semen Persicae (parched)s of 3 parts of Fructus Aurantii Immaturuss of Semen Pruni
1 part of 1 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched)
Preparation method is to get above-mentioned raw materials to decoct with water twice, 1.5～2 hours for the first time, and 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, one month is a course of treatment.
Claims (3)
1. Chinese medicine preparation for the treatment of constipation is characterized in that it is made by following raw materials by weight proportions:
2.5～10 parts of 1.5～6 portions of Folium Sennae of 2.5～10 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
1.5～6 parts of 1.5～6 parts of Semen Cassiaes of 2.5～10 portions of Aloes of Fructus Cannabis
1.5～6 parts of 1.5～6 parts of Semen Persicae (parched)s of 1.5～6 parts of Fructus Aurantii Immaturuss of Semen Pruni
0.1～2 part of 0.1～2 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched).
2. a kind of Chinese medicine preparation for the treatment of constipation according to claim 1, wherein the weight proportion of each crude drug is:
3～7 parts of 2.5～3.5 portions of Folium Sennae of 3～7 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
2.5～3.5 parts of 2.5～3.5 parts of Semen Cassiaes of 3～7 portions of Aloes of Fructus Cannabis
2.5～3.5 parts of 2.5～3.5 parts of Semen Persicae (parched)s of 2.5～3.5 parts of Fructus Aurantii Immaturuss of Semen Pruni
0.5～1.5 part of 0.5～1.5 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched).
3. a kind of Chinese medicine preparation for the treatment of constipation according to claim 1, wherein the weight proportion of each crude drug is:
5 parts of 3 portions of Folium Sennae of 5 parts of Natrii Sulfas of Radix Et Rhizoma Rhei
3 parts of 3 parts of Semen Cassiaes of 5 portions of Aloes of Fructus Cannabis
3 parts of 3 parts of Semen Persicae (parched)s of 3 parts of Fructus Aurantii Immaturuss of Semen Pruni
1 part of 1 portion of Fructus Crataegi of Endothelium Corneum Gigeriae Galli (parched).
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| CN101991100B (en) * | 2009-08-11 | 2012-08-22 | 天津开发区太人生物科技有限公司 | Health-care food for removing three toxins in human body, beautifying and resisting senium as well as preparation method thereof |
| CN102669656A (en) * | 2012-03-15 | 2012-09-19 | 李文化 | Green honey fruit (dietary therapy product) |
| CN103263568B (en) * | 2013-05-30 | 2014-08-20 | 朱项英 | Traditional Chinese medicine composition for preventing and treating constipation, ozostomia and adiposity, and preparation method thereof |
| CN103652855A (en) * | 2013-11-06 | 2014-03-26 | 胡安然 | Special diet for relaxing bowel |
| CN104069395A (en) * | 2014-06-23 | 2014-10-01 | 张玉雯 | Traditional Chinese medicine formula for treating constipation and preparation method of traditional Chinese medicine |
| CN105311068A (en) * | 2014-08-01 | 2016-02-10 | 薛永新 | Traditional Chinese medicine composition for losing weights and facilitating feces excretion |
| CN104474319A (en) * | 2014-11-25 | 2015-04-01 | 沙珍萍 | Bowel cleaning powder used before endoscopic operation in urinary surgery and preparation method thereof |
| CN104971171A (en) * | 2015-07-15 | 2015-10-14 | 唐冬香 | Bowel-relaxing detoxifying traditional Chinese medicine |
| CN105232854A (en) * | 2015-11-26 | 2016-01-13 | 河南中医学院 | Traditional Chinese medicine pill treating empirical constipation |
| CN105343512A (en) * | 2015-12-16 | 2016-02-24 | 齐鲁工业大学 | Traditional Chinese medicine composition for treating constipation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189346A (en) * | 1997-01-30 | 1998-08-05 | 张汉英 | Chinese medicine for treating constipation |
| CN1899505A (en) * | 2005-07-18 | 2007-01-24 | 成都康弘科技实业（集团）有限公司 | Medicine composition for clearing heat and purging-fire |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1189346A (en) * | 1997-01-30 | 1998-08-05 | 张汉英 | Chinese medicine for treating constipation |
| CN1899505A (en) * | 2005-07-18 | 2007-01-24 | 成都康弘科技实业（集团）有限公司 | Medicine composition for clearing heat and purging-fire |
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