CN101012419A - Application of hyaluronic acid in wine and beer containing hyaluronic acid - Google Patents
Application of hyaluronic acid in wine and beer containing hyaluronic acid Download PDFInfo
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- CN101012419A CN101012419A CN 200710079892 CN200710079892A CN101012419A CN 101012419 A CN101012419 A CN 101012419A CN 200710079892 CN200710079892 CN 200710079892 CN 200710079892 A CN200710079892 A CN 200710079892A CN 101012419 A CN101012419 A CN 101012419A
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Abstract
The invention discloses a hygienic beer with hyaluronic acid, which is characterized by the following: developing the physiological function of hyaluronic acid with alcohol at drinking time; protecting stomach film and liver; improving the vessel system and articular function.
Description
Technical field
The present invention relates to the health food technology field, be to be the health-care components of wine, and a kind of hyaluronic health-care beer that contains is provided with the hyaluronic acid.
The used hyaluronic acid of the present invention is meant the hyaluronic acid in any source, comprises hyaluronic acid and sodium salt thereof, i.e. hyaluronate sodium.
Background technology
Drinking has double influence to body, shows as: drink when an amount of, can alleviate anxiety, stimulate circulation, relax the muscles and stimulate the blood circulation, cardiovascular and cerebrovascular diseases is had certain prophylactic effect; When drinking beyond one's capacity, because of the ethanol in the wine (alcohol) has amphipathic, promptly have wetting ability and lipotropy concurrently, the space structure of lipid impacts in the meeting cell membrane, cause the damage of respective organization, as nervous system damage, cardiovascular and cerebrovascular damage, pallium atrophy, liver injury, gastrointestinal mucosa damage, stomach ulcer even gastrorrhagia and threat to life.Excessive consumption of alcohol is totally unfavorable to human body, but with a long history because of spirits culture, many people are often excessive consumption of alcohol still.Therefore, research minimizing ethanol is significant to the little health care drinks of actual bodily harm.
Hyaluronic acid (hyaluronic acid, claim glass acid again) be a kind of acidic mucopolysaccharide that alternately is formed by connecting by D-glucuronic acid and N-n acetylglucosamine n disaccharide unit, it extensively is present in the body, and is higher with the content of joint cavity, blood vessel, heart, eye, brain and skin etc.Studies show that oral hyaluronic acid has many physiological functions, damage, improve looks, improve cardiovascular systems, improve function of joint, improve osteoporosis as protection liver, prevention gastrointestinal mucosa.Contain hyaluronic protective foods and proposed multiple scheme, be applied in all kinds of wine but yet there are no it.
Summary of the invention
An object of the present invention is to propose hyaluronic acid as the application of health-care components in all kinds of wine.Above-mentioned all kinds of wine includes but not limited to beer, grape wine, fruit wine, yellow rice wine, rice wine, blue or green wine, kumiss, liquor, seasoning wine, Wine, preferably beer, grape wine, first-selected beer.The content of hyaluronic acid in wine is 0.01mg/L～2.0g/L, preferred 10.0mg/L～1.0g/L, first-selected 30.0mg/L～100.0mg/L.
The application method of hyaluronic acid in drinks is: (1) joined hyaluronic acid in the wine liquid before the production of wine enters the can operation.(2) hyaluronic acid is encased in the small package packaging container, before drinking, joins in the wine by the human consumer.It is the health-care beer of health-care components with the hyaluronic acid that another object of the present invention provides a kind of.The content of hyaluronic acid in beer is 0.01mg/L～2.0g/L, preferred 10.0mg/L～1.0g/L, first-selected 30.0mg/L～70.0mg/L.Also contain other compositions in the above-mentioned beer, wherein other compositions are selected from but are not limited to conventional beer composition and/or other health-care components, and wherein other health-care components are selected from but are not limited to xylo-bioses, glucosamine and/or Folium Ginkgo extract etc.
Health-care components of the present invention is a hyaluronic acid, and our test confirms, can be absorbed by body behind the oral hyaluronic acid.Hyaluronic acid in the drinks shows as two aspects to the health-care effect of body: (1) physical protection: hyaluronic acid is a kind of straight chain polymer polysaccharide; it forms the space reticulated structure after absorbing moisture; effective inclusion (inclution) ethanol; significantly regulate body alcoholic acid is absorbed and metabolism, thereby obviously improve the damage of drinking each tissue of human body and organ.In addition, the molecule barrier that hyaluronic acid solution forms also has the mucous membrane provide protection, can make gastrointestinal mucosa avoid alcoholic acid stimulation and damage, can play protection and plerosis function to positions such as gastrointestinal mucosa in damaged condition.Therefore, hyaluronic acid makes body avoid showing the intelligent protection effect aspect the ethanol damage.(2) physiological function: hyaluronic acid has protection liver, beauty treatment after body absorbs, improve cardio-cerebrovascular, improve function of joint, improve osteoporosis, remove many physiological functions such as oxyradical.
Hyaluronic acid is an ideal drinks health-care components, produces the health promoting wine with application prospect so can use it for.We find by test, and when the content of hyaluronic acid in beer was 30.0mg/L～70.0mg/L, its health-care effect was good.
Advantage of the present invention is: (1) is regulated alcoholic acid effectively and absorbed and metabolism: the space reticulated structure that forms behind the hyaluronic acid absorption moisture is inclusion ethanol effectively, significantly regulate body alcoholic acid is absorbed, thereby obviously improve the damage of drinking each tissue of human body and organ.(2) intelligent protection gastrointestinal mucosa: the molecule barrier that hyaluronic acid solution forms has the mucous membrane provide protection, can make gastrointestinal mucosa avoid alcoholic acid stimulation and damage, can also play protection and plerosis function to gastrointestinal mucosa in damaged condition.(3) given full play to hyaluronic acid in protection liver, beauty treatment, improve cardio-cerebrovascular, improve function of joint, improve osteoporosis, remove the physiological function that the aspect had such as oxyradical.(4) reduce the back the higher authorities' incidence of drinking: the cancellated clathration in hyaluronic antioxygenation and space thereof, can reduce the influence of the middle-and-high-ranking alcohol of wine to human body.(5) improve the quality of finished wine: hyaluronic acid can make wine have more mellow sense.For beer, add hyaluronic acid and can prevent its oxidation, make beer fresh delicious.For grape wine, add hyaluronic acid and can reduce astringent taste, and the stable of wine body worked.(6) hyaluronic health-care effect is combined with the effect that an amount of ethanol accelerate blood circulates, relaxes the muscles and stimulate the blood circulation, make health promoting wine have significant synergy, especially cardiovascular and cerebrovascular diseases is had certain prophylactic effect.(7) satisfied the consumers demand of people to drinks nutrient laden and health careization.
The embodiment of the invention
Application and a kind of health-care beer of embodiment 1 hyaluronic acid in beer
At first, the preparation sodium hyaluronate solution: the microparticle shape hyaluronate sodium of accurate weighing 6.0g, under whipped state, hyaluronate sodium is joined in the 20.0L water gradually, water temperature remains on about 72 ℃.The speed that adds hyaluronate sodium can not be too fast, and the water that should can be stirred rapidly with the hyaluronate sodium that adds is taken away but do not produced caking and is advisable, otherwise need to prolong swelling time.After treating that hyaluronate sodium all adds, more than abundant swelling 4h under the condition that does not need temperature control.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned swelling and the good hyaluronic acid solution of dissolving are evenly added in the beer of 580L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 5min, so that hyaluronate sodium homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making hyaluronic acid contents is the hyaluronic acid health-care beer product of some specifications of 0.01mg/L.
Application and a kind of health-care beer of embodiment 2 hyaluronic acids in beer
At first, the preparation sodium hyaluronate solution: the microparticle shape hyaluronate sodium of accurate weighing 18.0g, under whipped state, hyaluronate sodium is joined in the 20.0L water gradually, water temperature remains on about 72 ℃.The speed that adds hyaluronate sodium can not be too fast, and the water that should can be stirred rapidly with the hyaluronate sodium that adds is taken away but do not produced caking and is advisable, otherwise need to prolong swelling time.After treating that hyaluronate sodium all adds, more than abundant swelling 4h under the condition that does not need temperature control.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned swelling and the good hyaluronic acid solution of dissolving are evenly added in the beer of 580L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 5min, so that hyaluronate sodium homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making hyaluronic acid contents is the hyaluronic acid health-care beer product of some specifications of 30mg/L.
Application and a kind of health-care beer of embodiment 3 hyaluronic acids in beer
At first, the preparation sodium hyaluronate solution: the microparticle shape hyaluronate sodium of accurate weighing 42.0g, under whipped state, hyaluronate sodium is joined in the 20.0L water gradually, water temperature remains on about 72 ℃.The speed that adds hyaluronate sodium can not be too fast, and the water that should can be stirred rapidly with the hyaluronate sodium that adds is taken away but do not produced caking and is advisable, otherwise need to prolong swelling time.After treating that hyaluronate sodium all adds, more than abundant swelling 4h under the condition that does not need temperature control.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned swelling and the good hyaluronic acid solution of dissolving are evenly added in the beer of 580L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 5min, so that hyaluronate sodium homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making hyaluronic acid contents is the hyaluronic acid health-care beer product of some specifications of 70mg/L.
Application and a kind of health care red wine of embodiment 4 hyaluronic acids in grape wine
Buying commercially available alcoholic strength is 12% (V/V) red wine 50.0L, produces hyaluronic acid health care red wine of the present invention.
At first, the preparation sodium hyaluronate solution: the microparticle shape hyaluronate sodium of accurate weighing 4.04g, under whipped state, hyaluronate sodium is joined in the 0.5L water gradually, water temperature remains on about 72 ℃.The speed that adds hyaluronate sodium can not be too fast, and the water that should can be stirred rapidly with the hyaluronate sodium that adds is taken away but do not produced caking and is advisable, otherwise need to prolong swelling time.After treating that hyaluronate sodium all adds, more than abundant swelling 4h under the condition that does not need temperature control.
Secondly, stir on the limit, and the limit evenly is poured into above-mentioned swelling and the good hyaluronic acid solution of dissolving in the red wine of 50L.Stir 20min, so that hyaluronate sodium homodisperse in red wine.Make the hyaluronic acid health care red wine 50.5L that alcoholic strength is about 12% (V/V).
At last, can, decals, making hyaluronic acid contents is the hyaluronic acid health care red wine product of some specifications of 80mg/L.
Application and a kind of health-care spirit of embodiment 5 hyaluronic acids in liquor
Buying commercially available alcoholic strength is 39% (V/V) liquor 100L, produces hyaluronic acid health-care spirit of the present invention.
At first, the preparation sodium hyaluronate solution: the microparticle shape hyaluronate sodium of accurate weighing 20.5g, under whipped state, hyaluronate sodium is joined in the 2.50L water gradually, water temperature remains on about 72 ℃.The speed that adds hyaluronate sodium can not be too fast, and the water that should can be stirred rapidly with the hyaluronate sodium that adds is taken away but do not produced caking and is advisable, otherwise need to prolong swelling time.After treating that hyaluronate sodium all adds, more than abundant swelling 4h under the condition that does not need temperature control.
Secondly, stir on the limit, and the limit evenly is poured into above-mentioned swelling and the good hyaluronic acid solution of dissolving in the liquor of 100L.Stir 5min, so that hyaluronate sodium homodisperse in liquor.Making alcoholic strength is the hyaluronic acid health-care spirit 102.5L of 38% (V/V).
At last, can, decals, making hyaluronic acid contents is the hyaluronic acid health-care spirit product of some specifications of 200mg/L.
Experimental study data of the present invention
Investigation project 1: hyaluronic acid health-care spirit of the present invention to mouse stomach after the adjusting that absorbs of ethanol
Method: choose 20 of healthy Kunming mouses and test, be divided into 2 groups at random, 10 every group.Fasting (can't help water) 12h before the mouse experiment.The A group is irritated stomach and is given the common white spirit that alcoholic strength is 38% (V/V) (is that the dilution of 39% (V/V) liquor adding distil water forms by commercially available alcoholic strength), as positive controls; The B group is irritated stomach and is given the hyaluronic acid health-care spirit that alcoholic strength is 38% (V/V) (adopt the hyaluronic acid health-care spirit of the embodiment of the invention 5, wherein hyaluronic content is 200mg/L).Each group is irritated stomach dosage and is the 15ml/kg body weight, and after irritating stomach 30,60,120,240min carries out the tail vein and gets blood, adopts the alcohol concn in the gas chromatography determination blood, the results are shown in Table 1.
The regulating effect (to the influence of alcohol concn in the blood behind the mouse stomach) that table 1 hyaluronic acid absorbs ethanol
| Time (min) | The concentration of ethanol in blood (mg/ml) | |
| Positive controls | Hyaluronic acid health- |
|
| 30 60 120 240 | 2.71±0.11 1.85±0.07 1.50±0.08 0.89±0.05 | 2.05±0.09 b 1.63±0.06 a 1.01±0.07 b 0.21±0.04 b |
Annotate: compare with positive controls,
aThere is significant difference P＜0.01,
bThere is the utmost point significant difference P＜0.001
Test-results shows, compares with the common white spirit group, and the present invention's hyaluronic acid health-care spirit can significantly reduce the mouse concentration of ethanol in blood after drinking.Its mechanism may be that hyaluronic acid absorbs the space reticulated structure that forms behind the moisture ethanol is carried out effective inclusion, thereby significantly regulated body alcoholic acid is absorbed.
Investigation project 2: hyaluronic acid health-care beer of the present invention is to the provide protection of rat stomach mucous membrane
Method: choose 32 of healthy male Wistar rats and test, be divided into 4 groups at random, 8 every group.The A group is irritated stomach and is given distilled water, as model control group; The B group is irritated stomach and is given ordinary beer; The C group is irritated the hyaluronic acid health-care beer (hyaluronic content is 0.01mg/L) that stomach gives the embodiment of the invention 1; The D group is irritated the hyaluronic acid health-care beer (hyaluronic content is 70mg/L) that stomach gives the embodiment of the invention 3.Every day, am9:00 irritated stomach to rat, fasting (can't help water) 12h before the rat experiment, and free diet of all the other times, each group is irritated stomach dosage and is the 10ml/kg body weight, continuous irrigation stomach 7d.30min behind the last filling stomach, each treated animal is all irritated stomach and is given the dehydrated alcohol that dosage is the 5ml/kg body weight.Put to death rat behind the 1h, open the abdominal cavity, first ligation body of stomach pylorus end injects 4% formaldehyde solution 8ml from cardiac end, and the ligation cardiac end takes out body of stomach again, and it is soaked in 4% the formaldehyde solution.Behind the 15min, cut off coat of the stomach along greater gastric curvature, water flush away gastric content shakeouts stomach and is placed on the blank sheet of paper, with thieving paper the surface is blotted.Can be observed dehydrated alcohol and cause the damage in various degree of rat stomach mucous membrane, with the naked eye observe and measurement gastric mucosa damaged area, the results are shown in Table 2 in conjunction with dissecting microscope.
Table 2 hyaluronic acid is to the provide protection of rat stomach mucous membrane
| Gastric mucosa damage index (mm 2) | Damage inhibiting rate (%) | |
| The hyaluronic acid health-care beer group of the hyaluronic acid health-care beer group embodiment 3 of model control group ordinary beer group embodiment 1 | 86.11±34.30 81.60±32.71 57.68±18.73 a 39.73±18.89 b | 0 5.23 33.02 53.86 |
Annotate: compare with model control group,
aThere is significant difference P＜0.05,
bThere is significant difference P＜0.01
Test-results shows; compare with model control group; the ordinary beer group is to the effect of rat stomach mucosa injury unprotect; and hyaluronic acid health-care beer group of the present invention all can significantly reduce the damaged area of rat stomach mucous membrane; this explanation hyaluronic acid health-care beer has provide protection to the rat stomach mucosa injury, and hyaluronic acid contents protection better effects if when high.Its mechanism may be that hyaluronic acid absorbs the macromole space reticulated structure that forms behind the moisture and brings into play barrier action on the surface of gastric mucosa, makes gastrointestinal mucosa avoid alcoholic acid stimulation and damage, thereby realizes the protection to gastric mucosa.
Investigation project 3: the research of Absorption of Hyaluronic Acid after Oral Administration
Method: before animal experiment, earlier Healthy female Wistar rats is carried out serum screening, the rat of Serum hyaluronic acid concentration less than 180ng/mL is used for testing.Choose 24 of the qualified rats of serum screening and test, be divided into 3 groups at random, 8 every group, fasting (can't help water) 12h before the rat experiment.The A group is irritated stomach and is given physiological saline, as the blank group; B group and C organize and irritate stomach respectively to give hyaluronic acid dosage be 20mg/kg body weight and 120mg/kg body weight.Before irritating stomach and irritate behind the stomach 1,2,4,7,10,12h gets the about 0.5mL of blood in subclavian vein Dou Chu to each group, puts in the Eppendorf pipe respectively, carries out centrifugally when serum to be had is separated out, and prepares serum.Serum is stored in-80 ℃ of refrigerators, concentrates measurement.Each is organized the Serum hyaluronic acid concentration-time curve and sees Figure of description, and hyaluronic content sees Table 3 in the serum.
From Figure of description as can be known, peak value does not appear in the Serum hyaluronic acid concentration of physiological saline control group, but in various degree peak all appears in hyaluronic acid concentration in the serum of each hyaluronic acid group about 2h and 7h, and supposition is hyaluronic absorption peak.The asynchronism(-nization) that Serum hyaluronic acid concentration raises behind the medicine may be by hyaluronic acid at gastral different sites and cause with multi-form absorption.
Table 3 is respectively organized the content (ng/mL) of HA in the serum
| Time/h | Dosage/(mg/kg body weight) | ||
| Physiological saline | 20 | 120 | |
| 0 1 2 4 7 10 12 | 100.58±17.33 99.96±6.17 89.48±37.17 93.05±29.47 90.82±32.12 91.06±30.30 95.34±28.87 | 126.57±30.75 114.96±31.06 135.07±23.82 124.82±22.52 372.27±70.73 b 237.93±26.16 b 175.47±33.82 | 132.64±29.80 126.88±70.16 162.59±111.57 147.42±40.02 286.47±104.24 a 223.87±27.18 b 139.76±47.33 |
Annotate: compare with value before the medicine on the same group,
aThere is significant difference P＜0.01,
bThere is the utmost point significant difference P＜0.001
Experimental data is carried out statistical analysis show, compare with value before the medicine on the same group, each group all has significance to raise in the Serum hyaluronic acid concentration about 7h behind the medicine.According to area Δ AUC under the drug-time curve of each hyaluronic acid group of table 1 calculating
0-12h, the result is as follows: Δ AUC
0-12h(20mg/kg body weight group)=1061.22 ± 291.79 (nghmL
-1), Δ AUC
0-12h(120mg/kg body weight group)=772.75 ± 375.73 (nghmL
-1).The experimental result prompting can be absorbed by body behind the oral hyaluronic acid.
Claims (10)
1. hyaluronic acid is as the application of health-care components in drinks.
2. the described application of claim 1, wherein wine includes but not limited to beer, grape wine, fruit wine, yellow rice wine, rice wine, blue or green wine, kumiss, liquor, seasoning wine or Wine, preferably beer, grape wine, first-selected beer.
3. claim 1 or 2 described application is characterized in that, the content of hyaluronic acid in wine is 0.01mg/L～2.0g/L, preferred 10.0mg/L～1.0g/L, first-selected 30.0mg/L～100.0mg/L.
4. claim 1 or 2 described application is characterized in that, hyaluronic acid was joined in the wine liquid before the production of wine enters the can operation.
5. claim 1 or 2 described application is characterized in that, hyaluronic acid is encased in the small package packaging container, are joined in the wine before drinking by the human consumer.
6. a health-care beer is characterized in that containing hyaluronic acid.
7. a beer as claimed in claim 6 is characterized in that, the content of hyaluronic acid in beer is 0.01mg/L～2.0g/L, preferred 10.0mg/L～1.0g/L, first-selected 30.0mg/L～70.0mg/L.
8. one kind as claim 6 or 7 described beer, it is characterized in that, also contain other compositions.
9. a beer as claimed in claim 8 is characterized in that, other compositions are selected from but are not limited to conventional beer composition and/or other health-care components.
10. a beer as claimed in claim 9 is characterized in that, other health-care components are selected from but are not limited to xylo-bioses, glucosamine and/or Folium Ginkgo extract.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710079892 CN101012419A (en) | 2007-02-16 | 2007-02-16 | Application of hyaluronic acid in wine and beer containing hyaluronic acid |
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|---|---|---|---|
| CN 200710079892 CN101012419A (en) | 2007-02-16 | 2007-02-16 | Application of hyaluronic acid in wine and beer containing hyaluronic acid |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103666975A (en) * | 2013-12-24 | 2014-03-26 | 山西绿缘道酒业有限公司 | Compound wine and preparation method thereof |
| CN103937643A (en) * | 2014-05-08 | 2014-07-23 | 赵品玲 | Radix puerariae wine and preparation method thereof |
| CN110699219A (en) * | 2019-11-12 | 2020-01-17 | 华熙生物科技股份有限公司 | A compound wine containing gamma-aminobutyric acid and hyaluronic acid or its salt, and its preparation method |
| CN112680302A (en) * | 2021-01-29 | 2021-04-20 | 烟台麦特尔生物技术有限公司 | Low-intoxication-causing refined beer containing hyaluronic acid oligosaccharide and process thereof |
| CN112725128A (en) * | 2021-03-05 | 2021-04-30 | 华熙生物科技股份有限公司 | White spirit compound spirit, preparation method and method for reducing drunkenness degree |
| CN113403166A (en) * | 2021-07-07 | 2021-09-17 | 李雨根 | Efficient comprehensive utilization method of blueberries |
| CN113430079A (en) * | 2021-07-07 | 2021-09-24 | 李雨根 | Production method and product of blueberry hyaluronic acid white spirit |
| CN113430080A (en) * | 2021-07-07 | 2021-09-24 | 李雨根 | Production method and product of blueberry hyaluronic acid red wine |
| CN113831992A (en) * | 2021-10-12 | 2021-12-24 | 江南大学 | Hyaluronic acid composition, compound wine containing hyaluronic acid composition and application of hyaluronic acid composition and compound wine |
| CN114098080A (en) * | 2021-11-18 | 2022-03-01 | 山东沛学生物工程有限公司 | Effervescent tablet containing hyaluronic acid and lutein ester and application of effervescent tablet in wine product |
| CN114340397A (en) * | 2019-09-10 | 2022-04-12 | 奇华顿股份有限公司 | Mouthfeel and astringency modulation in compositions and methods of modulating mouthfeel and astringency in compositions |
| CN115820356A (en) * | 2022-12-30 | 2023-03-21 | 北京燕京啤酒股份有限公司 | Fruit-flavored beer added with sodium hyaluronate and preparation method thereof |
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2007
- 2007-02-16 CN CN 200710079892 patent/CN101012419A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103666975A (en) * | 2013-12-24 | 2014-03-26 | 山西绿缘道酒业有限公司 | Compound wine and preparation method thereof |
| CN103937643A (en) * | 2014-05-08 | 2014-07-23 | 赵品玲 | Radix puerariae wine and preparation method thereof |
| CN114340397A (en) * | 2019-09-10 | 2022-04-12 | 奇华顿股份有限公司 | Mouthfeel and astringency modulation in compositions and methods of modulating mouthfeel and astringency in compositions |
| CN110699219A (en) * | 2019-11-12 | 2020-01-17 | 华熙生物科技股份有限公司 | A compound wine containing gamma-aminobutyric acid and hyaluronic acid or its salt, and its preparation method |
| CN112680302A (en) * | 2021-01-29 | 2021-04-20 | 烟台麦特尔生物技术有限公司 | Low-intoxication-causing refined beer containing hyaluronic acid oligosaccharide and process thereof |
| CN112725128A (en) * | 2021-03-05 | 2021-04-30 | 华熙生物科技股份有限公司 | White spirit compound spirit, preparation method and method for reducing drunkenness degree |
| CN113430079A (en) * | 2021-07-07 | 2021-09-24 | 李雨根 | Production method and product of blueberry hyaluronic acid white spirit |
| CN113430080A (en) * | 2021-07-07 | 2021-09-24 | 李雨根 | Production method and product of blueberry hyaluronic acid red wine |
| CN113403166A (en) * | 2021-07-07 | 2021-09-17 | 李雨根 | Efficient comprehensive utilization method of blueberries |
| CN113831992A (en) * | 2021-10-12 | 2021-12-24 | 江南大学 | Hyaluronic acid composition, compound wine containing hyaluronic acid composition and application of hyaluronic acid composition and compound wine |
| CN114098080A (en) * | 2021-11-18 | 2022-03-01 | 山东沛学生物工程有限公司 | Effervescent tablet containing hyaluronic acid and lutein ester and application of effervescent tablet in wine product |
| CN114098080B (en) * | 2021-11-18 | 2024-03-29 | 山东沛学生物工程有限公司 | Effervescent tablet containing hyaluronic acid and lutein ester and application of effervescent tablet in wine products |
| CN115820356A (en) * | 2022-12-30 | 2023-03-21 | 北京燕京啤酒股份有限公司 | Fruit-flavored beer added with sodium hyaluronate and preparation method thereof |
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