CN101002832B - Granulated quickly dissolving medicine for relaxing bowel - Google Patents
Granulated quickly dissolving medicine for relaxing bowel Download PDFInfo
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- CN101002832B CN101002832B CN2006101244422A CN200610124442A CN101002832B CN 101002832 B CN101002832 B CN 101002832B CN 2006101244422 A CN2006101244422 A CN 2006101244422A CN 200610124442 A CN200610124442 A CN 200610124442A CN 101002832 B CN101002832 B CN 101002832B
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- 239000003814 drug Substances 0.000 title description 3
- 230000002040 relaxant effect Effects 0.000 title description 2
- 206010010774 Constipation Diseases 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract 2
- 238000012856 packing Methods 0.000 claims abstract 2
- 239000008187 granular material Substances 0.000 claims description 13
- 235000013325 dietary fiber Nutrition 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 5
- 229940013618 stevioside Drugs 0.000 claims description 5
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 5
- 235000019202 steviosides Nutrition 0.000 claims description 5
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims 1
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims 1
- 235000012907 honey Nutrition 0.000 abstract description 4
- 210000000936 intestine Anatomy 0.000 abstract description 4
- 239000000835 fiber Substances 0.000 abstract description 2
- 239000002245 particle Substances 0.000 abstract 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 6
- 210000003608 fece Anatomy 0.000 description 5
- 239000008141 laxative Substances 0.000 description 5
- 230000002475 laxative effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- -1 dry at 45°C Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 108700012359 toxins Proteins 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 206010038038 rectal cancer Diseases 0.000 description 2
- 201000001275 rectum cancer Diseases 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000324 minimal toxicity Toxicity 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940085678 polyethylene glycol 8000 Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
技术领域technical field
本发明涉及保健食品，具体地说是一种润肠通便速溶颗粒剂。The invention relates to a health food, in particular to an instant granule for moistening intestines and laxative.
背景技术Background technique
便秘是一种常见病和多发病，不同的年龄组都有习惯性便秘的人群，老年性便秘更为常见。食物中纤维含量不足，便会排泄不畅。但蛋白质和脂肪等食物在消化吸收后多少会产生各种毒素。便秘会使体内产生的毒素长期存留在肠道内，不仅会导致消化不良，食欲不振，而且肠道粘膜受到毒素刺激，长期便秘，会提高直肠癌、结肠癌及其他相关癌症的风险。目前市场上有很多润肠通便的药品和保健食品，但普遍效果不佳，或常伴有不同程度的副作用。Constipation is a common and frequently-occurring disease. There are people with habitual constipation in different age groups, and senile constipation is more common. Insufficient fiber content in food will lead to poor excretion. However, foods such as protein and fat will produce various toxins after digestion and absorption. Constipation will cause toxins produced in the body to remain in the intestinal tract for a long time, not only leading to indigestion and loss of appetite, but also the intestinal mucosa is stimulated by toxins. Long-term constipation will increase the risk of rectal cancer, colon cancer and other related cancers. There are many laxative medicines and health food on the market, but the general effect is not good, or often accompanied by side effects in varying degrees.
发明内容Contents of the invention
本发明的目的在于克服现有技术的不足，提供一种副作用小，又具有良好效果的润肠通便、排除肠道积存毒素的保健品。The purpose of the present invention is to overcome the deficiencies of the prior art and provide a health care product that has less side effects and has a good effect of relaxing bowels and eliminating toxins accumulated in the intestinal tract.
本发明解决上述技术问题所采用的技术方案为：The technical solution adopted by the present invention to solve the problems of the technologies described above is:
一种润肠通便速溶颗粒剂，其特征是按以下方法制成的：An instant laxative granule for moistening intestines is characterized in that it is made by the following method:
将20～60重量份的聚乙二醇4000、40～80重量份的水溶性膳食纤维、0～20重量份的蜂蜜、0～0.2重量份的甜菊糖和0～0.3的果味香精充分混匀，搅拌制粒，45℃干燥，整粒，包装。Fully mix 20-60 parts by weight of polyethylene glycol 4000, 40-80 parts by weight of water-soluble dietary fiber, 0-20 parts by weight of honey, 0-0.2 parts by weight of stevioside and 0-0.3 parts by weight of fruit flavor Homogenize, stir and granulate, dry at 45°C, granulate, and pack.
聚乙二醇4000是用环氧乙烷与水聚合而成的混合物，是一种治疗成人功能性便秘有效、安全的药物。药理作用是通过氢键固定肠腔内固有的水分子，使水分保留在结肠内，增加粪便含水量，使粪便体积及重量增加，软化粪便，促进粪便在肠腔中的运转，改善便秘，恢复正常的排便规律。它在消化道内不被吸收或代谢，不影响脂溶性维生素的吸收和电解质的代谢。其毒性极小，使用安全。Polyethylene glycol 4000 is a mixture of ethylene oxide and water polymerized. It is an effective and safe drug for treating functional constipation in adults. The pharmacological effect is to fix the inherent water molecules in the intestinal lumen through hydrogen bonds, keep the water in the colon, increase the water content of the feces, increase the volume and weight of the feces, soften the feces, promote the movement of the feces in the intestinal lumen, improve constipation, and restore Normal bowel movements. It is not absorbed or metabolized in the digestive tract, and does not affect the absorption of fat-soluble vitamins and the metabolism of electrolytes. It has minimal toxicity and is safe to use.
水溶性膳食纤维又称功能性多聚葡萄糖，是一种具有保健功能的食品添加剂。水溶性膳食纤维具有良好的持水性，可使粪便软化，调节肠道功能，增加排泄物的体积，缩短其在肠内的通过时间，防止便秘，减少有毒及致癌物的吸收。它能阻碍对葡萄糖及胆固醇的吸收，调节血糖水平，促使粪便内中性固醇的排泄，因而具有热量低、降血脂、降血糖、减肥、通便、防止直肠癌的功能。Water-soluble dietary fiber, also known as functional polydextrose, is a food additive with health care functions. Water-soluble dietary fiber has good water holding capacity, can soften stool, regulate intestinal function, increase the volume of excrement, shorten its passage time in the intestine, prevent constipation, and reduce the absorption of toxic and carcinogenic substances. It can hinder the absorption of glucose and cholesterol, regulate blood sugar levels, and promote the excretion of neutral sterols in the feces, so it has the functions of low calories, lowering blood fat, lowering blood sugar, losing weight, laxative, and preventing rectal cancer.
本发明的特点在于运用具有药理作用的聚乙二醇4000与水溶性膳食纤维复配，制成通便保健的固体速溶颗粒剂，其不同于常用的泻药，对人体不会造成伤害及使用者对产品的依赖，是现代人一种良好的润肠通便保健品。The feature of the present invention is to compound polyethylene glycol 4000 with pharmacological effects and water-soluble dietary fiber to make solid instant granules for defecation and health care. Reliance on the product is a good laxative health care product for modern people.
具体实施方式Detailed ways
实施例1：Example 1:
将2000克的聚乙二醇4000、8000克的水溶性膳食纤维、2000克的蜂蜜、10克的甜菊糖和20克的果味香精充分混匀，搅拌制粒，45℃干燥，整粒，包装。Fully mix 2000 grams of polyethylene glycol 4000, 8000 grams of water-soluble dietary fiber, 2000 grams of honey, 10 grams of stevioside and 20 grams of fruity flavor, stir and granulate, dry at 45 ° C, and granulate. Package.
实施例2：Example 2:
将6000克的聚乙二醇4000、4000克的水溶性膳食纤维、1000克的蜂蜜、20克的甜菊糖和20克的果味香精充分混匀，搅拌制粒，45℃干燥，整粒，包装。Fully mix 6000 grams of polyethylene glycol 4000, 4000 grams of water-soluble dietary fiber, 1000 grams of honey, 20 grams of stevioside and 20 grams of fruity flavor, stir and granulate, dry at 45 ° C, granulate, Package.
实施例3：Example 3:
将4000克的聚乙二醇4000、6000克的水溶性膳食纤维、10克的甜菊糖和10克的果味香精充分混匀，搅拌制粒，45℃干燥，整粒，包装。4,000 grams of polyethylene glycol 4,000 grams, 6,000 grams of water-soluble dietary fiber, 10 grams of stevioside and 10 grams of fruity essence are fully mixed, stirred and granulated, dried at 45°C, granulated, and packaged.
实施例4：Example 4:
将6000克的聚乙二醇4000和8000克的水溶性膳食纤维充分混匀，搅拌制粒，45℃干燥，整粒，包装。Fully mix 6000 grams of polyethylene glycol 4000 and 8000 grams of water-soluble dietary fiber, stir and granulate, dry at 45°C, granulate, and pack.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101244422A CN101002832B (en) | 2006-09-02 | 2006-09-02 | Granulated quickly dissolving medicine for relaxing bowel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101244422A CN101002832B (en) | 2006-09-02 | 2006-09-02 | Granulated quickly dissolving medicine for relaxing bowel |
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| Publication Number | Publication Date |
|---|---|
| CN101002832A CN101002832A (en) | 2007-07-25 |
| CN101002832B true CN101002832B (en) | 2011-01-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006101244422A Active CN101002832B (en) | 2006-09-02 | 2006-09-02 | Granulated quickly dissolving medicine for relaxing bowel |
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| Country | Link |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20120555A1 (en) * | 2012-11-13 | 2014-05-14 | Aboca Spa Societa Agricola | Enemas. |
| AU2017241904A1 (en) * | 2016-03-29 | 2018-10-18 | Colonaryconcepts Llc | Formulations for treating constipation |
| CN106235341A (en) * | 2016-07-30 | 2016-12-21 | 南京正宽医药科技有限公司 | A kind of bamboo shoot edible fiber extracting method and the granule for the treatment of constipation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710183A (en) * | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| CN1341016A (en) * | 1999-02-22 | 2002-03-20 | 史密丝克莱恩比彻姆公司 | Effervescent laxatives |
-
2006
- 2006-09-02 CN CN2006101244422A patent/CN101002832B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5710183A (en) * | 1995-07-14 | 1998-01-20 | Halow; George M. | Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent |
| CN1341016A (en) * | 1999-02-22 | 2002-03-20 | 史密丝克莱恩比彻姆公司 | Effervescent laxatives |
Non-Patent Citations (3)
| Title |
|---|
| 中华医学会消化病学分会.慢性便秘的诊治指南.中华内科杂志43 1.2004,43(1),73-74. |
| 中华医学会消化病学分会.慢性便秘的诊治指南.中华内科杂志43 1.2004,43(1),73-74. * |
| 江国虹.膳食纤维干预改善便秘的研究.天津医科大学硕士学位论文.2005,15. * |
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| CN101002832A (en) | 2007-07-25 |
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